CN1272786A - 内皮素拮抗剂和β-受体阻滞剂的组合制剂 - Google Patents
内皮素拮抗剂和β-受体阻滞剂的组合制剂 Download PDFInfo
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- CN1272786A CN1272786A CN98809727A CN98809727A CN1272786A CN 1272786 A CN1272786 A CN 1272786A CN 98809727 A CN98809727 A CN 98809727A CN 98809727 A CN98809727 A CN 98809727A CN 1272786 A CN1272786 A CN 1272786A
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- Prior art keywords
- endothelin antagonist
- combination
- beta
- blocker
- alkyl
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
N | 初始值 | 1小时 | 2小时 | 3小时 | 4小时 | 5小时 | 6小时 | |
对照 | 10 | 103 | 3 | 2 | 2 | 1 | 1 | 1 |
化合物A10mg/kg | 10 | 99.6 | -5.9 | -8.9 | -9.0 | -9.1 | -8.4 | -8.2 |
布新洛尔0.1mg/kg | 5 | 100.4 | -0.8 | -3.8 | -3.4 | -3.8 | -3.8 | -1.4 |
化合物A+布新洛尔10+0.1mg/kg | 5 | 100.8 | -8.8 | -15.2 | -17 | -15.6 | -13.4 | -11.8 |
Claims (4)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19743143.7 | 1997-09-30 | ||
DE19743143A DE19743143A1 (de) | 1997-09-30 | 1997-09-30 | Pharmazeutische Kombinationspräparate |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1272786A true CN1272786A (zh) | 2000-11-08 |
CN1149087C CN1149087C (zh) | 2004-05-12 |
Family
ID=7844115
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB988097273A Expired - Fee Related CN1149087C (zh) | 1997-09-30 | 1998-09-10 | 内皮素拮抗剂和β-受体阻滞剂的组合制剂 |
Country Status (17)
Country | Link |
---|---|
US (1) | US6352992B1 (zh) |
EP (1) | EP1019055B1 (zh) |
JP (1) | JP4608093B2 (zh) |
KR (1) | KR100623122B1 (zh) |
CN (1) | CN1149087C (zh) |
AT (1) | ATE239479T1 (zh) |
AU (1) | AU739860B2 (zh) |
BR (1) | BR9812404A (zh) |
CA (1) | CA2304698C (zh) |
CZ (1) | CZ298745B6 (zh) |
DE (2) | DE19743143A1 (zh) |
ES (1) | ES2199461T3 (zh) |
HK (1) | HK1032355A1 (zh) |
HU (1) | HU226745B1 (zh) |
NO (1) | NO319048B1 (zh) |
RU (1) | RU2213577C2 (zh) |
WO (1) | WO1999016444A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104887645A (zh) * | 2015-06-15 | 2015-09-09 | 吉林万通药业集团梅河药业股份有限公司 | 阿莫西林胶囊及其制备方法 |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
DE60120104T2 (de) | 2001-03-20 | 2006-09-21 | Schwarz Pharma Ag | Neue Verwendung von Peptidverbindungen bei der Behandlung von nicht-neuropathischem Entzündungsschmerz |
DE60100055T2 (de) | 2001-03-21 | 2003-07-24 | Sanol Arznei Schwarz Gmbh | Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen |
EP1734980A1 (en) | 2004-04-16 | 2006-12-27 | Schwarz Pharma Ag | Use of peptidic compounds for the prophylaxis and treatment of chronic headache |
PL1781276T3 (pl) | 2004-08-27 | 2010-11-30 | Ucb Pharma Gmbh | Zastosowanie związków peptydowych do leczenia bólu związanego z rakiem kości, bólu indukowanego przez chemioterapię oraz nukleozydy |
US20070196510A1 (en) * | 2006-02-17 | 2007-08-23 | Gerber Michael J | Method for treating resistant hypertension |
EP2037965B1 (en) | 2006-06-15 | 2017-08-30 | UCB Pharma GmbH | Pharmaceutical composition with synergistic anticonvulsant effect |
US20090054473A1 (en) | 2007-08-22 | 2009-02-26 | Gilead Colorado, Inc. | Therapy for complications of diabetes |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4786441A (en) * | 1987-08-24 | 1988-11-22 | International Business Machines Corporation | Preparation of iodonium and sulfonium triflates |
SE8704081D0 (sv) * | 1987-10-21 | 1987-10-21 | Haessle Ab | A new prohylactic method |
EP0617001B1 (en) * | 1993-03-19 | 2000-01-26 | Merck & Co. Inc. | Phenoxyphenylacetic acid derivatives |
JPH09508378A (ja) * | 1994-01-28 | 1997-08-26 | シーエーエル・インターナショナル・リミテッド | エステル化可能なβ遮断薬のサリチレートを含む医薬製造物 |
DE19533023B4 (de) * | 1994-10-14 | 2007-05-16 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung |
EP0799051B1 (en) * | 1994-12-12 | 2005-07-27 | Omeros Corporation | Irrigation solution and use thereof for perioperatively inhibiting pain, inflammation and spasm at a wound |
PL184060B1 (pl) * | 1995-01-27 | 2002-08-30 | Rhone Poulenc Rorer Ltd | Podstawione związki fenylowe do zastosowania jako środki antagonistyczne endoteliny |
DE19636046A1 (de) * | 1996-09-05 | 1998-03-12 | Basf Ag | Neue Carbonsäurederivate, ihre Herstellung und Verwendung als gemischte ET¶A¶/ET¶B¶-Rezeptorantagonisten |
DE19652374A1 (de) * | 1996-12-04 | 1998-06-10 | Schering Ag | Verwendung von Endothelin-Konjugaten in der Therapie, neue Endothelin-Konjugate, diese enthaltende Mittel, sowie Verfahren zu deren Herstellung |
CN1247533A (zh) * | 1996-12-18 | 2000-03-15 | Basf公司 | 杂环羧酸衍生物,它们的制备方法和它们作为内皮素(endothelin)受体拮抗剂的用途 |
-
1997
- 1997-09-30 DE DE19743143A patent/DE19743143A1/de not_active Withdrawn
-
1998
- 1998-09-10 CA CA002304698A patent/CA2304698C/en not_active Expired - Fee Related
- 1998-09-10 BR BR9812404-8A patent/BR9812404A/pt active Search and Examination
- 1998-09-10 CZ CZ20001081A patent/CZ298745B6/cs not_active IP Right Cessation
- 1998-09-10 DE DE59808297T patent/DE59808297D1/de not_active Expired - Lifetime
- 1998-09-10 RU RU2000111500/14A patent/RU2213577C2/ru not_active IP Right Cessation
- 1998-09-10 CN CNB988097273A patent/CN1149087C/zh not_active Expired - Fee Related
- 1998-09-10 EP EP98945323A patent/EP1019055B1/de not_active Expired - Lifetime
- 1998-09-10 JP JP2000513580A patent/JP4608093B2/ja not_active Expired - Fee Related
- 1998-09-10 AT AT98945323T patent/ATE239479T1/de active
- 1998-09-10 US US09/508,989 patent/US6352992B1/en not_active Expired - Lifetime
- 1998-09-10 KR KR1020007003346A patent/KR100623122B1/ko not_active IP Right Cessation
- 1998-09-10 HU HU0004590A patent/HU226745B1/hu not_active IP Right Cessation
- 1998-09-10 WO PCT/EP1998/005772 patent/WO1999016444A1/de active IP Right Grant
- 1998-09-10 ES ES98945323T patent/ES2199461T3/es not_active Expired - Lifetime
- 1998-09-10 AU AU92672/98A patent/AU739860B2/en not_active Ceased
-
2000
- 2000-03-29 NO NO20001634A patent/NO319048B1/no not_active IP Right Cessation
-
2001
- 2001-04-25 HK HK01102973A patent/HK1032355A1/xx not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104887645A (zh) * | 2015-06-15 | 2015-09-09 | 吉林万通药业集团梅河药业股份有限公司 | 阿莫西林胶囊及其制备方法 |
CN104887645B (zh) * | 2015-06-15 | 2016-12-14 | 吉林万通药业集团梅河药业股份有限公司 | 阿莫西林胶囊及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
NO20001634D0 (no) | 2000-03-29 |
CA2304698C (en) | 2008-02-19 |
HUP0004590A2 (hu) | 2001-11-28 |
NO319048B1 (no) | 2005-06-06 |
JP2001517703A (ja) | 2001-10-09 |
US6352992B1 (en) | 2002-03-05 |
HK1032355A1 (en) | 2001-07-20 |
KR100623122B1 (ko) | 2006-09-12 |
EP1019055A1 (de) | 2000-07-19 |
CZ20001081A3 (en) | 2001-05-16 |
AU9267298A (en) | 1999-04-23 |
ATE239479T1 (de) | 2003-05-15 |
ES2199461T3 (es) | 2004-02-16 |
EP1019055B1 (de) | 2003-05-07 |
RU2213577C2 (ru) | 2003-10-10 |
KR20010015650A (ko) | 2001-02-26 |
CN1149087C (zh) | 2004-05-12 |
NO20001634L (no) | 2000-03-29 |
WO1999016444A1 (de) | 1999-04-08 |
CA2304698A1 (en) | 1999-04-08 |
BR9812404A (pt) | 2000-09-19 |
AU739860B2 (en) | 2001-10-25 |
CZ298745B6 (cs) | 2008-01-16 |
DE19743143A1 (de) | 1999-04-01 |
HUP0004590A3 (en) | 2002-01-28 |
JP4608093B2 (ja) | 2011-01-05 |
DE59808297D1 (de) | 2003-06-12 |
HU226745B1 (en) | 2009-09-28 |
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