CN1268360C - Pathogenic fire purging Chinese medicinal tablet containing borneol and nantural oindigo and preparation method thereof - Google Patents
Pathogenic fire purging Chinese medicinal tablet containing borneol and nantural oindigo and preparation method thereof Download PDFInfo
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- CN1268360C CN1268360C CNB2004100908592A CN200410090859A CN1268360C CN 1268360 C CN1268360 C CN 1268360C CN B2004100908592 A CNB2004100908592 A CN B2004100908592A CN 200410090859 A CN200410090859 A CN 200410090859A CN 1268360 C CN1268360 C CN 1268360C
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- 238000010926 purge Methods 0.000 title claims abstract description 32
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- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 title abstract 3
- 229940116229 borneol Drugs 0.000 title abstract 3
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- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 title abstract 3
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims abstract description 5
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- 229940097275 indigo Drugs 0.000 claims abstract 3
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- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 18
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- Medicines Containing Plant Substances (AREA)
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Abstract
The present invention discloses a Chinese medicine pathogenic fire purging tablet which comprises (based on preparing 1000 of pathogenic fire purging tablets and the unit is gram): 120 to 200 of rhubarb, 80 to 150 of pearl, 150 to 190 of natural indigo, 80 to 150 of mirabilitum praeparatum, 2 to 50 of bezoar and 10 to 50 of borneol. The present invention has the preparation method that (1) the required amount of rhubarb is pulverized into coarse granulates after washed and dried, and then the rhubarb is leached by using 75% of alcohol, effective components in the rhubarb are extracted, and the alcohol is recovered and is concentrated into thick extract; (2) the pearl, the bezoar, the mirabilitum praeparatum, the natural indigo, etc. are respectively pulverized and are screened by a No. 7 screen to be used; (3) 350 grams of dried cane sugar powder and 50 grams of dextrin are placed in an appropriate container and are added with a medicine obtained from step (1) and step (2) to be uniformly mixed, appropriate amount of 70% of syrup is added in case of necessity and is manufactured into soft material by adjusting the humidity, grains are manufactured by using a granulating machine, and the grains are sieved by using a screen with 8 to 10 meshes after dried; (4) the borneol is dissolved in 95% of alcohol, is uniformly sprayed in the grains, is aired and is added with 20g of talcum powder and 8g of magnesium stearate to be thoroughly and uniformly mixed, and a product of the present invention can be obtained by pressing the grains, the talcum powder and the magnesium stearate into pieces. The product is particularly suitable for treating oral cavity ulcer, the curative effects are significant, and the present invention is without toxic and side effects.
Description
Technical field
The present invention relates to a kind of Chinese medicine and ice blue or green pathogenic fire purging sheet, belong to medical preparing technical field.
Background technology
The pars oralis pharyngis disease is a human big illness, and China has 700,000,000 populations to suffer from various degree pars oralis pharyngis disease approximately according to statistics, is commonly encountered diseases and frequently-occurring disease with oral ulcer (being aphtha) especially, and sickness rate is at 10-30%, and shows effect no specific treatment method repeatedly.At present, treat this disease and generally use antibiotics class medicine,, use this class medicine to exist sick light medicine heavy, easily make patient produce the shortcoming of drug resistance and dysbacteriosis as penicillin and streptomycin, tetracycline etc.; The use vitamins that also has, as VB2, though this class medicine is cheap, curative effect is not high; In addition, use the Chinese medicine BINGPENG SAN, though the energy anti-inflammatory analgetic, the insufficiency of function of removing the necrotic tissue and promoting granulation; Though the treatment of use cow-bezoar bolus for clearing away heat of the upper part of the body effectively, does not have efficiently, and often has side effects.
Summary of the invention
The objective of the invention is at the prior art above shortcomings, provide a kind of Chinese medicine to ice blue or green pathogenic fire purging sheet and preparation method thereof.
Design of the present invention is such: according to traditional Chinese medical science internal organs intenseness of heat, heat is taken advantage of heart spleen, and gas so make the principle of aphtha of the mouth and tongue, adopts the pathogenic fire purging of the bitter energy of Radix Et Rhizoma Rhei, the heat clearing away of cold energy towards in mouth and tongue; The Margarita calming liver and clearing heat, the arresting convulsion of calming the nerves, convergence granulation promoting; Indigo Naturalis, Borneolum Syntheticum, watermelon crystal go into that heart spleen, eliminating stagnation reduce phlegm, reducing swelling and alleviating pain, and the function of evacuation of pus granulation promoting is a principal agent with Radix Et Rhizoma Rhei, Indigo Naturalis, Borneolum Syntheticum, are aided with Margarita, Calculus Bovis and watermelon crystal and make Chinese medicine at interior medicine and ice blue or green pathogenic fire purging sheet.Product of the present invention not only boil on the nape opposite the mouth disease of pharynx has significant heat-clearing and toxic substances removing, the effect of reducing swelling and alleviating pain, putrefaction-removing granulation-promoting, and diseases such as body surface and mucosal inflammation, ulcer and burn are all had very high curative effect, and do not have toxic and side effects.
Particularly; the effective ingredient that a kind of Chinese medicine of the present invention is iced blue or green pathogenic fire purging sheet is to be principal agent with Radix Et Rhizoma Rhei, Indigo Naturalis, Borneolum Syntheticum; accessory drugs comprises watermelon crystal, Margarita, Calculus Bovis etc., and it is specifically formed proportioning and comprises following active ingredient (being as the criterion unit to prepare the blue or green pathogenic fire purging sheet of 1000 flake ices: restrain):
Radix Et Rhizoma Rhei 120-200 Margarita 80-150
Indigo Naturalis 150-190 watermelon crystal 80-150
Calculus Bovis 2-50 Borneolum Syntheticum 10-50
Through experiment showed, repeatedly in product of the present invention, when the consumption of Radix Et Rhizoma Rhei is lower than 120 grams, the function of tonic chord of the heat clearing away of the blue or green pathogenic fire purging sheet of ice, pathogenic fire purging is descended, influence its curative effect; When consumption is higher than 200 grams, will cause patient's times of defecation to increase, therefore, the consumption of Radix Et Rhizoma Rhei is preferably between the 120-200 gram, but is preferably 190 grams;
When the consumption of Margarita is lower than 80 grams, will make the clear pathogenic fire purging sheet calming liver and clearing heat of ice, the function of tonic chord of convergence granulation promoting descends, and influences the curative effect of product putrefaction-removing granulation-promoting of the present invention; When being higher than 100 grams, do not influence the function and the curative effect of product of the present invention, also do not produce any side effect, but will significantly improve the cost of the blue or green pathogenic fire purging sheet of ice, therefore, its consumption is preferably between the 80-100 gram, but best consumption is 100 grams;
When the consumption of Indigo Naturalis, Borneolum Syntheticum is lower than 150 grams and 30 grams respectively, will the effect of product heat-clearing and toxic substances removing of the present invention, anti-inflammatory analgetic be descended; But, when the consumption of Indigo Naturalis is higher than 200 grams, might produce harmful effect to the hematopoietic function of human body, therefore, the consumption of Indigo Naturalis should be between 150～190, and the optimum amount of Indigo Naturalis, Borneolum Syntheticum is respectively 180 and 30 grams;
The optimum amount of watermelon crystal and Calculus Bovis is respectively 120 grams and 6 grams; So the best proportioning of forming of the present invention is (being as the criterion unit to prepare the blue or green pathogenic fire purging sheet of 1000 flake ices: restrain):
Radix Et Rhizoma Rhei 190 gram Margaritas 100 grams
Indigo Naturalis 180 gram watermelon crystals 120 grams
Calculus Bovis 6 gram Borneolum Syntheticums 30 grams
Because of Borneolum Syntheticum has sensiblely, therefore kind function of scurrying adds Borneolum Syntheticum and can make other each herbal medicine in the invention product ratio of components bring into play its effect better, add Calculus Bovis purpose be for pathogenic fire purging poison, clearing away heart-fire, the row knot stagnates, the detumescence pain.
The using method that product of the present invention is iced blue or green pathogenic fire purging sheet is: mouthful including, each a slice, every day 3-5 time.
The preparation method of the blue or green pathogenic fire purging sheet of ice of the present invention may further comprise the steps:
(1) Radix Et Rhizoma Rhei of aequum cleaned, after the drying, be ground into the coarse granule shape, use 75% ethanol percolation then, extract effective ingredient wherein, recovered alcohol is condensed into thick extractum;
(2) Margarita, Calculus Bovis, watermelon crystal, Indigo Naturalis etc. are pulverized respectively, and crossed sieve No. seven, standby;
(3) get dry cane sugar powder 350 grams, dextrin (pharmaceutical aids) 50 grams, put in the appropriate containers, add step (1), (2) technical process gained medicament mixed is even, add an amount of 70% syrup in case of necessity, adjust humidity and make soft material, granulate with granulator then, dry back 8-10 mesh sieve granulate;
(4) Borneolum Syntheticum is dissolved with 95% ethanol, evenly be sprayed in the granule, airing adds Pulvis Talci 20g, magnesium stearate 8 grams, and abundant mix homogeneously, tabletting, every heavy 1 gram promptly gets product of the present invention.
The present invention compared with prior art has the following advantages: 1. clinical treatment aphtha 300 examples, and observation group is with the blue or green pathogenic fire purging sheet of ice, effective percentage 98%; The matched group BINGPENG SAN, effective percentage 66.6%, there is significant differences statistical procedures P＜0.01; 2. treatment must aim at the pathogenesis of disease, treating both the principal and secondary aspects of a disease, the traditional Chinese medical science thinks that " damp and hot stifling, Borneolum Syntheticum is a distinguishing feature, adopts Radix Et Rhizoma Rhei eliminating fire and detoxication, activating blood circulation and dissipating blood stasis, and is equipped with Indigo Naturalis, heat-clearing and toxic substances removing, the pathogenic fire purging abnormal pigmentary deposit on the skin that disappears; Borneolum Syntheticum pathogenic fire purging pain relieving, the Margarita removing the necrotic tissue and promoting granulation, all medicines supplement and complement each other, and strike home; 3. discard the dross and select the essential, medical herbs is purified more can bring into play drug effect; 4. local application makes diseased region drug level height, has avoided the liver first-pass effect again; 5. nontoxic, the side effect of product of the present invention, application safety is reliable.
The specific embodiment
Following embodiment is in order to explanation the present invention.
Embodiment
Below having provided product of the present invention ices three groups of blue or green pathogenic fire purging sheet and differently forms proportionings (to prepare the blue or green pathogenic fire purging sheet of 1000 flake ices is benchmark.Unit: gram):
First group:
Radix Et Rhizoma Rhei 120 Margaritas 80 Calculus Boviss 3
Indigo Naturalis 150 watermelon crystals 150 Borneolum Syntheticums 10
Second group
Radix Et Rhizoma Rhei 160 Margaritas 120 Calculus Boviss 15
Indigo Naturalis 170 watermelon crystals 100 Borneolum Syntheticums 20
The 3rd group
Radix Et Rhizoma Rhei 190 Margaritas 100 Calculus Boviss 6
Indigo Naturalis 180 watermelon crystals 120 Borneolum Syntheticums 30
To be respectively applied for the toxicity test that rabbit, Cavia porcellus carry out toxicity test and agents area than obtained medicine by above-mentioned three assembly, the result shows that product of the present invention is without any side effects; Above-mentioned three assembly are carried out the drug effect zoology test than obtained medicine, the result shows, product of the present invention is to staphylococcus aureus, Staphylococcus albus and Klebsiella pneumoniae all have antibacterial action, antibacterial action to fungus is particularly powerful, can reduce inflammatory sign occurrence rate to the guinea pig skin traumatic ulcer, and have the effect of accelerating wound healing, different inflammatory animal models are had tangible antiinflammatory action.
Be respectively applied for than the medicine of gained with above-mentioned three assembly animal is carried out the antiulcer test, the result shows, than obtained effect of drugs the best, the best group of the blue or green pathogenic fire purging sheet of ice promptly of the present invention becomes that (to be equipped with the blue or green pathogenic fire purging sheet of 1000 flake ices is benchmark with the 3rd assembly.Unit: gram):
Radix Et Rhizoma Rhei 190 Margaritas 100 Calculus Boviss 6
Indigo Naturalis 180 watermelon crystals 120 Borneolum Syntheticums 30
The concrete preparation method of the said goods comprises following technical process:
(1) Radix Et Rhizoma Rhei of aequum cleaned, after the drying, be ground into the coarse granule shape, use 75% ethanol percolation then, extract active ingredient wherein, recovered alcohol is condensed into thick extractum;
(2) Margarita, Calculus Bovis, watermelon crystal, Indigo Naturalis etc. are pulverized respectively, and crossed sieve No. seven, standby;
(3) get dry sugarcane powder 350 grams, dextrin 50 grams, put in the appropriate containers, add step (1), (2) technical process gained medicament mixed is even, add an amount of 70% syrup in case of necessity, adjust humidity and make soft material, granulate with granulator then, dry back 8-10 mesh sieve granulate;
(4) Borneolum Syntheticum is dissolved with 95% ethanol, evenly be sprayed in the granule airing; Add Pulvis Talci 20g, magnesium stearate 8 grams, abundant mix homogeneously, tabletting, every heavy 1 gram promptly gets product of the present invention.
Product of the present invention is dun tablet, and the sweet in the mouth cold shows through stability test, and product room temperature of the present invention was placed 18 months down, and testing result meets quality standard.
Use according to three tame provincial hospitals, ice blue or green pathogenic fire purging sheet clinical observation test, the result shows that product of the present invention truly has heat-clearing and toxic substances removing, reducing swelling and alleviating pain, the effect of putrefaction-removing granulation-promoting is applicable to oral cavity, pharyngeal and body surface and mucosal inflammation, ulcer etc. that accumulation of heat in the heart and spleen, hyperactivity of fire caused by deficiency of YIN, flaming up of stomach-fire and wind heat cause.Be applicable to aphtha of the mouth and tongue, gingival swelling and pain, fester that symptoms such as red swelling of the pharynx causalgia are to diseases such as oral ulcer, acute/chronic pharyngitis, gingivitis, periodontitis and body surface, mucosal ulcer.Especially oral ulcer is had specially good effect, pain can disappear in patient's medication 3-5 minute, and ulcer disappeared in 3-5 days, and effect is remarkable.
The using method of product of the present invention is: ice blue or green pathogenic fire purging sheet, each a slice, every day 3-5 time, containing.
Claims (3)
1, a kind of Chinese medicine is iced blue or green pathogenic fire purging sheet, it is characterized in that making the active ingredient raw material and consists of: be as the criterion to prepare the blue or green pathogenic fire purging sheet of 1000 flake ices, unit is gram.
Radix Et Rhizoma Rhei 120---200 Margarita 80---150 Indigo Naturalis 150---190
Watermelon crystal 80---150 Calculus Bovis 2---50 Borneolum Syntheticum 10---50.
2, ice blue or green pathogenic fire purging sheet by claims 1 described Chinese medicine, it is characterized in that making the active ingredient raw material and consist of: be as the criterion to prepare the blue or green pathogenic fire purging sheet of 1000 flake ices, unit is gram
Radix Et Rhizoma Rhei 190 Margaritas 100 Indigo Naturaliss 180
Watermelon crystal 120 Calculus Boviss 6 Borneolum Syntheticums 30.
3, a kind of preparation method of icing blue or green pathogenic fire purging sheet as claim 1 or 2 described Chinese medicines is characterized in that may further comprise the steps:
(1) Radix Et Rhizoma Rhei of aequum cleaned, after the drying, be ground into the coarse granule shape, use 75% ethanol percolation then, extract active ingredient wherein, recovered alcohol is condensed into thick extractum;
(2), and cross sieve No. seven with Margarita, Calculus Bovis, watermelon crystal, Indigo Naturalis pulverize separately, standby;
(3) get pharmaceutical aidses such as dry cane sugar powder 350 grams, dextrin 50 gram, put in the appropriate containers, add (1), (2) step gained medicament mixed is even, add an amount of 70% syrup, suitable humidity is made soft material, granulates with granulator then, dry back 8-10 mesh sieve granulate;
(4) Borneolum Syntheticum is dissolved with 95% ethanol, evenly be sprayed in step (3) the gained granule, airing adds Pulvis Talci 20 grams, magnesium stearate 8 grams, and abundant mix homogeneously, tabletting, every heavy 1 gram promptly gets product of the present invention.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100908592A CN1268360C (en) | 2004-11-16 | 2004-11-16 | Pathogenic fire purging Chinese medicinal tablet containing borneol and nantural oindigo and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100908592A CN1268360C (en) | 2004-11-16 | 2004-11-16 | Pathogenic fire purging Chinese medicinal tablet containing borneol and nantural oindigo and preparation method thereof |
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| Publication Number | Publication Date |
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| CN1634450A CN1634450A (en) | 2005-07-06 |
| CN1268360C true CN1268360C (en) | 2006-08-09 |
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| CNB2004100908592A Active CN1268360C (en) | 2004-11-16 | 2004-11-16 | Pathogenic fire purging Chinese medicinal tablet containing borneol and nantural oindigo and preparation method thereof |
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| CN102133292B (en) * | 2011-02-28 | 2012-08-29 | 常熟华港制药有限公司 | Oral Chinese medicine preparation for treating chronic periodontitis and preparation method thereof |
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