CN1262951A - Medicine for curing arthralgia-syndrome resulted from wind,cold and dampness and its preparation method - Google Patents
Medicine for curing arthralgia-syndrome resulted from wind,cold and dampness and its preparation method Download PDFInfo
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- CN1262951A CN1262951A CN 99116354 CN99116354A CN1262951A CN 1262951 A CN1262951 A CN 1262951A CN 99116354 CN99116354 CN 99116354 CN 99116354 A CN99116354 A CN 99116354A CN 1262951 A CN1262951 A CN 1262951A
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Abstract
The Chinese medicine for curing impediment and numbness caused by wind, cold and damp is made up by using 10-odd Chinese medicinal materials of aconite main tuber, wild aconite tuber, notopterygium root and pubescent angelica root, etc. through a preparation process including moistening with ethyl alcohol and soaking at a certain temp.. It features simple preparation process, convenient application and obvious therapeutic effect.
Description
The invention belongs to and a kind ofly be used for the treatment of that it is is the medicine that raw material is made with Chinese herbal medicine mainly by wind, cold, wet arthralgia-syndrome resulted definite the saying of medicine, the invention still further relates to the manufacture method of this medicine.
By wind, it is cold, wet that to invade human body arthralgia-syndrome resulted be a kind of common frdquently encountered disease, this disease is brought very big misery to the patient.Present known Therapeutic Method often adopts oral medicine and beats the Therapeutic Method of sealing, but oral medicine often has side effect to human body, and the therapeutic process of playing sealing can bring misery to the patient again.Application number is that 95109257 patent application discloses the rheumatismal plaster of a kind of treatment for this reason, this plaster is made up by a certain percentage by medicines such as taro head, Rhizoma Zingiberis, Radix Clematidis, Radix Zanthoxyli, Radix Achyranthis Bidentatae, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Cortex Acanthopanciss, be coated with and make through Oleum Sesami immersion, heating extraction active ingredient, oil refining, following Plumbum preparatium, detoxification, stand, this plaster is effective in cure to treatment rheumatism, but it can not to because of wind, arthromyodynia due to cold, wet all effective in cure, moreover this plaster is attached to the affected part for a long time, can make some patients cause the skin Pruritus.
The objective of the invention is to: providing a kind of is primary raw material with the Chinese herbal medicine to by wind, cold, wet arthralgia-syndrome resulted all effective in cure, can directly act on the sick position of patient, externally applied liniment easy to use.
The present invention also aims to: the preparation method that this medicine is provided.
The object of the invention solution is based in motherland's medical treasure-house elaboration and the Therapeutic Principle to the pathogenic factor mechanism of arthromyodynia, filter out have dispel the wind, the medicine of cold expelling, dehumidifying, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, dredge the meridian passage, and form in conjunction with the research prescription manufacturing of modern pharmacology, drug effect.
Medicine of the present invention comprises that following component makes (consumption is a weight portion)
15～30 parts of 6～20 portions of Rhizoma Et Radix Notopterygiis of 5～15 portions of Radix Aconiti Kusnezoffii of Radix Aconiti
8～24 parts of 7～20 parts of Radix Angelicae Sinensis of 8～25 parts of Semen Strychni of Radix Angelicae Pubescentis (system)
6～16 parts on 6～18 parts of Flos Carthamis of 5～16 parts of Herba Asaris of Arisaema Cum Bile
6～15 parts of 4～1 portions of Cortex Cinnamomis of 9～23 portions of Rhizoma Zingiberiss of Radix Aconiti Lateralis Preparata (system)
20～38 parts of 14～32 parts of Myrrha (processed) of 8～26 parts of Olibanums of Rhizoma Chuanxiong (system)
6～16 parts of 6～16 parts of Mentholums of 12～22 parts of Borneolum Syntheticums of Sanguis Draxonis
5～20 parts in Radix Glycyrrhizae
Its preparation method is followed successively by:
A, take by weighing by proportioning: Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Semen Strychni (system), Radix Angelicae Sinensis, Arisaema Cum Bile, Herba Asari, Flos Carthami, Radix Aconiti Lateralis Preparata (system), Rhizoma Zingiberis, Cortex Cinnamomi, Rhizoma Chuanxiong, Olibanum (system), Myrrha (processed), Sanguis Draxonis, Radix Glycyrrhizae, mix the back and pulverize and make coarse powder.
B, moistening medicated powder: getting concentration is 60%, and weight is the ethanol of 4～6.5 times of above-mentioned raw materials total amounts, and above-mentioned coarse powder is moistening and stir, and in the percolator of packing into, sealing was placed 4～8 hours in 10 ℃～30 ℃ temperature;
C, pharmaceutical-impregnated: getting concentration again is 60%, weight is 3～5 times ethanol of institute's consumption first time, and ethanol is added in the medicated powder of above-mentioned moistening back, and ethanol adds to the medicated powder upper surface medicine is flooded, all the other ethanol stay stand-by, and the medicine of dipping was placed 48 hours in 10 ℃～30 ℃ temperature.
D, medicine percolation: with the speed of the per minute 1～3ml medicinal liquid after with above-mentioned dipping percolation slowly, percolation limit, limit adds residue ethanol in the weighing, when being 4～6.5 times of the total dose of 17 flavor medicines such as Radix Aconiti, Radix Aconiti Kusnezoffii, the liquid weight of filtering of collecting stops percolation, medicinal residues are squeezed, medicinal liquid merges with the medicinal liquid that squeezes out filtering out, under 10 ℃～20 ℃ temperature, leave standstill 24 hours, and after-filtration;
The preparation of e, Borneolum Syntheticum, Mentholum solution: take by weighing Borneolum Syntheticum and Mentholum in the weight proportion respectively, put into the ethanol that container respectively adds 4～6 times of their weight respectively, concentration of alcohol is 60%, makes its dissolving;
F, be mixed with: Borneolum Syntheticum, Mentholum solution are mixed with filtered liquid medicine;
Medicine respectively distinguish the flavor of among the present invention by appropriate preparation, therefore it dispel the wind, cold expelling, dehumidifying, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain effect are remarkable especially, especially to muscles and bones, muscle, arthralgia, diseases such as Hucklebone neuralgia, arthroncus and traumatic injury have the obvious treatment effect, it is simpler that medicine of the present invention also has manufacturing process, use superiority very easily, the patient need not take medicine, and only needs can obtain significant effect in the disease sites erasing.
The present invention is used for clinical, and its result is as follows:
With 237 patients is example:
237 routine arthromyodynia patients are divided into treatment by randomly assigne and organize 177 examples all from outpatient service and ward, matched group 60 examples.Treatment is organized in 177 examples: male 74 examples, women 103 examples, 18～62 years old age, the course of disease 30 days～18 years, average 3.36 years; In matched group 60 examples, male 26 examples, women 34 examples, 18～61 years old age, the course of disease 40 days～17 years, average 3.54, two groups were similar substantially on the clinical symptoms light and heavy degree, have comparability.
One, case choice criteria
(1) diagnostic criteria
1, main clinic symptoms and sign: position pain such as joint, muscle, muscles and bones, acid precipitation or swelling, morning deadlock, numbness or joint stuffiness.
2, characteristics of incidence: how relevant with climate change.
Two, Therapeutic Method
Adopt single blind method, the treatment group is dried after local the cleaning with drug prepared treatment of the present invention, and every day 2 times, 10 days is a course of treatment.Matched group is treated with ZHENGHONGHUA YOU, and the usage and the course of treatment are with the treatment group.
Three, therapeutic outcome
(1) scoring method is adopted in state of an illness classification, degrees of symptoms: local pains such as joint, muscle, swelling, numbness, bent and stretched the serious meter of movable five equilibrium 4 minutes; Restatement 3 minutes; Fell into a trap 2 fens; Light meter 1 minute; 0 fen level Four of meter disappears.
(2) curative effect determinate standard
1, clinical cure: symptom all disappears, and functional rehabilitation is normal, and main physico-chemical examination index is normal.
2, produce effects: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered normally can participate in operate as normal and work substantially, and the physico-chemical examination index is normal substantially, its integrated value decline 2/3 above person.
3, effective: cardinal symptom changes to some extent, and joint or limbs recover to some extent, and its integrated value descends more than 1/3, but deficiency.
4, invalid: sings and symptoms does not all have improvement, its integrated value decline less than 1/3 or no change person.
(3) result: see the following form
Two groups of Comparison of therapeutic
| Group | Add up to | Clinical cure | Produce effects | Effectively | Invalid | Add up to | Total effective rate (%) |
| The treatment group | ??177 | ????42 | ???85 | ???42 | ????8 | ??177 | ????95.5 |
| Matched group | ??60 | ????3 | ???28 | ???21 | ????8 | ??60 | ????86.7 |
By finding out in the last table, treatment is organized in 177 examples, clinical cure 42 examples (23.7%), and in matched group 60 examples, clinical cure 3 examples (5%) are learned by statistics and are handled, and treatment group total effective rate is 95.5%, and the matched group total effective rate is 86.7%.
Be described further below in conjunction with embodiment.
Embodiment 1:
A, by taking by weighing medicine (is unit with the kilogram) in the proportioning dose:
Radix Aconiti 1.2 Radix Aconiti Kusnezoffii 1.5 Rhizoma Et Radix Notopterygiis 3
Radix Angelicae Pubescentis 2.3 Semen Strychni (system) 2.3 Radix Angelicae Sinensis 2.3
Arisaema Cum Bile 1.5 Herba Asaris 1.5 Flos Carthamis 1.5
Radix Aconiti Lateralis Preparata (system) 2.3 Rhizoma Zingiberiss 1.5 Cortex Cinnamomis 1.5
Rhizoma Chuanxiong 2.3 Olibanums (system) 3 Myrrha (processed) 2.8
Sanguis Draxonis 2.3 Borneolum Syntheticums 1.5 Mentholums 1.5
Radix Glycyrrhizae 1.5
B, get the Radix Aconiti, Radix Aconiti Kusnezoffii, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Semen Strychni (system), Radix Angelicae Sinensis, Arisaema Cum Bile, Herba Asari, Flos Carthami, Radix Aconiti Lateralis Preparata (system), Rhizoma Zingiberis, Cortex Cinnamomi, Rhizoma Chuanxiong, Olibanum (system), Myrrha (processed), Sanguis Draxonis, Radix Glycyrrhizae, the mixed powder that weigh up in the medicine and be broken into coarse powder.
C, being that coarse powder after 60% ethanol is pulverized medicine is moistening and stir with 150 kilograms of concentration, is airtight placement 6 hours under 15 ℃ the situation in temperature in the percolator of then packing into.
D, to take by weighing 900 kilograms of concentration be 60% ethanol, getting in these ethanol a part adds in moistening and medicine that sealing was placed medicine is flooded, it is equal with the medicated powder upper surface that ethanol is added to, and all the other ethanol stay stand-by, then pharmaceutical-impregnated placed 48 hours under 20 ℃ of temperature.
E, the medicine behind the dipping with 1～3ml/ minute speed percolation, percolation limit, limit is in the above-mentioned ethanol adding medicine that stays, and when waiting percolation to go out medicinal liquid to be 150 kilograms, stops percolation, then medicinal residues squeezed.The medicinal liquid that squeezes out mixes with the percolation medicinal liquid, then filters after leaving standstill 24 hours under 10 ℃～15 ℃ temperature.
F, the ethanol that the Borneolum Syntheticum that weighs and Mentholum are put into 15 kilograms 60% concentration respectively dissolve.
G, with the solution of Borneolum Syntheticum and Mentholum and filter the back medicinal liquid and mix, be distributed into bottle then and get final product.
Embodiment 2:
This routine Chinese medicine, by taking by weighing medicine (is unit with the kilogram) in the proportioning dose:
Radix Aconiti 4 Radix Aconiti Kusnezoffii 5 Rhizoma Et Radix Notopterygiis 10
Radix Angelicae Pubescentis 7.5 Semen Strychni (system) 7.5 Radix Angelicae Sinensis 7.5
Arisaema Cum Bile 5 Herba Asaris 5 Flos Carthamis 5
Radix Aconiti Lateralis Preparata (system) 7.5 Rhizoma Zingiberiss 5 Cortex Cinnamomis 5
Rhizoma Chuanxiong 7.5 Olibanums (system) 10 Myrrha (processed) 2.5
Sanguis Draxonis 7.5 Borneolum Syntheticums 5 Mentholums 5
Radix Glycyrrhizae 5
In preparation technology: wet medicated used ethanol is 700 kilograms, and the used ethanol of pharmaceutical-impregnated is 2800 kilograms, and each uses 20 kilograms of ethanol dissolving Borneolum Syntheticum and Mentholum.Operating procedure and step are with embodiment 1 in pharmacy procedure.
Embodiment 3:
In the present embodiment: selecting for use on the medicine and dosage basis identical, adding the tall and erect copper of a kind of powerful transdermal agent nitrogen in addition, to strengthen the purpose that medicine is absorbed by rapid transdermal with embodiment 2.
The manufacturing process of present embodiment is identical with embodiment 1.Just after medicinal liquid was made, the tall and erect copper of 0.5～1% of the adding amount of liquid medicine nitrogen then stirred and gets final product in medicinal liquid.
Claims (6)
1. a treatment is by wind, cold, wet arthralgia-syndrome resulted medicine, and it is characterized in that: this drug main will be made (consumption is a weight portion) by following component:
15～30 parts of 6～20 portions of Rhizoma Et Radix Notopterygiis of 5～15 portions of Radix Aconiti Kusnezoffii of Radix Aconiti
8～24 parts of 7～20 parts of Radix Angelicae Sinensis of 8～25 parts of Semen Strychni of Radix Angelicae Pubescentis (system)
6～16 parts on 6～18 parts of Flos Carthamis of 5～16 parts of Herba Asaris of Arisaema Cum Bile
6～15 parts of 4～16 portions of Cortex Cinnamomis of 9～23 portions of Rhizoma Zingiberiss of Radix Aconiti Lateralis Preparata (system)
20～38 parts of 14～32 parts of Myrrha (processed) of 8～26 parts of Olibanums of Rhizoma Chuanxiong (system)
6～16 parts of 6～16 parts of Mentholums of 12～22 parts of Borneolum Syntheticums of Sanguis Draxonis
5～20 parts in Radix Glycyrrhizae
2. treatment according to claim 1 is by wind, cold, wet arthralgia-syndrome resulted medicine, and it is characterized in that: its optimum ratio is:
15～25 parts of 8～15 portions of Rhizoma Et Radix Notopterygiis of 6～12 portions of Radix Aconiti Kusnezoffii of Radix Aconiti
12～18 parts of 8～16 parts of Radix Angelicae Sinensis of 12～20 parts of Semen Strychni of Radix Angelicae Pubescentis (system)
6～13 parts on 8～15 parts of Flos Carthamis of 7～15 parts of Herba Asaris of Arisaema Cum Bile
8～12 parts of 6～15 portions of Cortex Cinnamomis of 10～20 portions of Rhizoma Zingiberiss of Radix Aconiti Lateralis Preparata (system)
20～28 parts of 16～28 parts of Myrrha (processed) of 10～18 parts of Olibanums of Rhizoma Chuanxiong (system)
8～15 parts of 6～13 parts of Mentholums of 16～21 parts of Borneolum Syntheticums of Sanguis Draxonis
6～14 parts in Radix Glycyrrhizae
3. treatment according to claim 1 and 2 by wind, cold, wet arthralgia-syndrome resulted its optimum weight proportioning of medicine is:
20 parts of 10 portions of Rhizoma Et Radix Notopterygiis of 8 portions of Radix Aconiti Kusnezoffii of Radix Aconiti
15 parts of 15 parts of Radix Angelicae Sinensis of 15 parts of Semen Strychni of Radix Angelicae Pubescentis (system)
10 parts on 10 parts of Flos Carthamis of 10 parts of Herba Asaris of Arisaema Cum Bile
10 parts of 10 portions of Cortex Cinnamomis of 15 portions of Rhizoma Zingiberiss of Radix Aconiti Lateralis Preparata (system)
25 parts of 20 parts of Myrrha (processed) of 15 parts of Olibanums of Rhizoma Chuanxiong (system)
10 parts of 10 portions of Herba Menthaes of 15 parts of Borneolum Syntheticums of Sanguis Draxonis born of the same parents
10 parts in Radix Glycyrrhizae
4. according to the treatment of claim 1 or 2 or 3 preparation method, it is characterized in that by wind, cold, wet arthralgia-syndrome resulted medicine:
A, take by weighing raw material of Chinese medicine by proportioning;
B, with in the proportioning: Radix Aconiti (system), Radix Aconiti Kusnezoffii (system), Radix Angelicae Sinensis, Arisaema Cum Bile, Semen Strychni (system), Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Herba Asari, Flos Carthami, Radix Aconiti Lateralis Preparata, Rhizoma Zingiberis, Cortex Cinnamomi, Rhizoma Chuanxiong, Olibanum (system), Myrrha (processed), Sanguis Draxonis, Radix Glycyrrhizae, pulverize and make coarse powder:
C, be 60% with concentration, weight is 4～6.5 times ethanol of said medicine total amount, and above-mentioned coarse powder is moistening and stir, and in the percolator of packing into, sealing was placed 4～8 hours in 10～30 ℃ temperature;
D, to get concentration again be 60%, and weight is 3～5 times alcohol dipping of amount of alcohol in the wet medicated operation, and impregnated medicine was placed 48 hours in 10～30 ℃ temperature;
E, with the speed of the per minute 1～3ml medicinal liquid after with above-mentioned dipping percolation slowly, when the weight of percolate is 4～6.5 times of 17 herbal medicine weight such as river, Radix Aconiti Kusnezoffii, stop percolation, medicinal residues are squeezed; The medicinal liquid of filtering out is merged with the medicinal liquid that squeezes out, static, and after-filtration;
F, take by weighing Borneolum Syntheticum and Mentholum in the proportioning, put into container respectively and add 4～6 times of 60% concentration ethanol of their weight, make their dissolvings;
G, Borneolum Syntheticum, Mentholum solution are mixed with filtered liquid medicine.
5. preparation method according to claim 4 is characterized in that: in the medicine after moistening dipping operation, should earlier a part of ethanol be added in the medicine after moistening, ethanol should add to equal with powder, and residue ethanol is when percolation, and percolation limit, limit adds; Filter out and should after leaving standstill 24 hours under 10 ℃～20 ℃ temperature, refilter after the medicinal liquid of medicinal liquid and squeezing merges.
6. according to claim 4 or 5 described preparation methoies, it is characterized in that: at the tall and erect copper of medicinal liquid and the nitrogen that adds both total amounts 0.5～1% after Borneolum Syntheticum, Mentholum solution mix again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116354A CN1092981C (en) | 1999-02-09 | 1999-02-09 | Medicine for curing arthralgia-syndrome resulted from wind,cold and dampness and its preparation method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN99116354A CN1092981C (en) | 1999-02-09 | 1999-02-09 | Medicine for curing arthralgia-syndrome resulted from wind,cold and dampness and its preparation method |
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| CN1262951A true CN1262951A (en) | 2000-08-16 |
| CN1092981C CN1092981C (en) | 2002-10-23 |
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| CN99116354A Expired - Fee Related CN1092981C (en) | 1999-02-09 | 1999-02-09 | Medicine for curing arthralgia-syndrome resulted from wind,cold and dampness and its preparation method |
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| CN102416049A (en) * | 2011-12-06 | 2012-04-18 | 常西海 | Small square type rheumatoid swelling diminishing and pain eliminating plaster and preparation method thereof |
| CN102920871A (en) * | 2011-08-12 | 2013-02-13 | 余新将 | Traditional Chinese medicine for treating rheumatoid bone diseases |
| CN103301424A (en) * | 2013-05-24 | 2013-09-18 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for activating meridians to stop pain for therapy of medicinal cupping and application thereof |
| CN103356864A (en) * | 2012-04-04 | 2013-10-23 | 吴舒克 | Aerosol spray for treating cervical spondylosis |
| CN104474190A (en) * | 2014-12-08 | 2015-04-01 | 唐武 | Foot-soaking traditional Chinese medicine composition for treating rheumatism |
| CN104922305A (en) * | 2015-05-25 | 2015-09-23 | 广州市开丽冷热设备有限公司 | Externally-applied traditional Chinese medicine composition for treating wind cold wetness type syndrome and preparation method thereof |
| CN107929485A (en) * | 2016-10-12 | 2018-04-20 | 田飞虎 | Tincture that treatment traumatic injury, scald, snakeworm bite and preparation method thereof |
| CN108066545A (en) * | 2018-02-02 | 2018-05-25 | 山东老董药业有限公司 | It is a kind of to treat myalgia muscle and joint disease plaster |
| CN109381583A (en) * | 2018-12-29 | 2019-02-26 | 莫留臣 | A kind of plaster and preparation method thereof for treating rheumatism bone disease |
| CN109939214A (en) * | 2019-04-30 | 2019-06-28 | 眉山市中医医院(眉山市东坡区人民医院) | A kind of Chinese medicine composition of warming and activating meridian, eliminating cold to stop pain |
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1999
- 1999-02-09 CN CN99116354A patent/CN1092981C/en not_active Expired - Fee Related
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| CN102920871A (en) * | 2011-08-12 | 2013-02-13 | 余新将 | Traditional Chinese medicine for treating rheumatoid bone diseases |
| CN102920871B (en) * | 2011-08-12 | 2014-06-04 | 余新将 | Traditional Chinese medicine for treating rheumatoid bone diseases |
| CN102416049A (en) * | 2011-12-06 | 2012-04-18 | 常西海 | Small square type rheumatoid swelling diminishing and pain eliminating plaster and preparation method thereof |
| CN102416049B (en) * | 2011-12-06 | 2014-07-09 | 常西海 | Small square type rheumatoid swelling diminishing and pain eliminating plaster and preparation method thereof |
| CN103356864A (en) * | 2012-04-04 | 2013-10-23 | 吴舒克 | Aerosol spray for treating cervical spondylosis |
| CN103301424A (en) * | 2013-05-24 | 2013-09-18 | 上海中医药大学附属岳阳中西医结合医院 | Traditional Chinese medicine composition for activating meridians to stop pain for therapy of medicinal cupping and application thereof |
| CN104474190A (en) * | 2014-12-08 | 2015-04-01 | 唐武 | Foot-soaking traditional Chinese medicine composition for treating rheumatism |
| CN104922305A (en) * | 2015-05-25 | 2015-09-23 | 广州市开丽冷热设备有限公司 | Externally-applied traditional Chinese medicine composition for treating wind cold wetness type syndrome and preparation method thereof |
| CN107929485A (en) * | 2016-10-12 | 2018-04-20 | 田飞虎 | Tincture that treatment traumatic injury, scald, snakeworm bite and preparation method thereof |
| CN108066545A (en) * | 2018-02-02 | 2018-05-25 | 山东老董药业有限公司 | It is a kind of to treat myalgia muscle and joint disease plaster |
| CN109381583A (en) * | 2018-12-29 | 2019-02-26 | 莫留臣 | A kind of plaster and preparation method thereof for treating rheumatism bone disease |
| CN109939214A (en) * | 2019-04-30 | 2019-06-28 | 眉山市中医医院(眉山市东坡区人民医院) | A kind of Chinese medicine composition of warming and activating meridian, eliminating cold to stop pain |
| CN111228450A (en) * | 2020-01-15 | 2020-06-05 | 常州博尔美美容管理有限公司 | Traditional Chinese medicine bone disease formula |
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| CN1092981C (en) | 2002-10-23 |
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