CN1259344A - Prepn. technique for Chinese traditional medicine capsule - Google Patents
Prepn. technique for Chinese traditional medicine capsule Download PDFInfo
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- CN1259344A CN1259344A CN 99126334 CN99126334A CN1259344A CN 1259344 A CN1259344 A CN 1259344A CN 99126334 CN99126334 CN 99126334 CN 99126334 A CN99126334 A CN 99126334A CN 1259344 A CN1259344 A CN 1259344A
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Abstract
The present invention relates to the prepn. technology of Chinese traditional medicine capsule which includes extract part of the crude drugs and concentrate to liquid extract, grind the other part of crude drugs into fine powder, sieve to obtain medicinal powder, combine the liquid extract and fine powder, mix and dry and encapsulate into capsules. Said process can reduce man hour to half, riase the rate of sinished product by 3%, control stable humidity, process in closed environment, so reduces contamination and pollution.
Description
The present invention relates to preparation method of Chinese medicine, particularly a kind of preparation technology of Chinese medicinal capsule agent.
Now, Chinese medicinal capsule generally still adopts the traditional preparation method of China in the preparation, is about to the part medical material through extracting, and extracting solution is condensed into flowing soaking paste, with vacuum drying under the uniform temperature, is ground into fine powder, sieves to obtain part fine powder I; Another part pulverizing medicinal materials is become fine powder, and sieving obtains part fine powder II, and again with fine powder I and II mix homogeneously, packing gets final product.
The purpose of this invention is to provide the preparation technology of Chinese medicinal capsule agent who a kind ofly promotes the modernization of Chinese medicine, improves the inherent quality of product.
The preparation technology of Chinese medicinal capsule agent of the present invention comprises that extracting solution is condensed into flowing soaking paste (I), and another part pulverizing medicinal materials is become fine powder, sieves to obtain powder II with the extraction of part medical material process; With fluid extract (I) and fine powder (II) step combination drying, divide packing to get product again.
Wherein, fluid extract is 1.21 ± 0.4 70 ℃ relative density, and the relative density when for example preparing brain-invigorating and heart-soothing capsule is 1.21 ± 0.4.
The temperature of one step combination drying of described fluid extract and fine powder is 40-60 ℃, and the temperature of the combination drying when for example preparing brain-invigorating and heart-soothing capsule is 40-60 ℃.
One step combination drying of described fluid extract and fine powder can carry out in multi-functional coating machine, and concrete technological parameter is respectively: charging temperature 40-50 ℃ time the in the equipment; The medicated powder temperature sprays cream when reaching 40-50 ℃; Air inflow in the hydrojet process is controlled at 2500-3000m
3/ h; Intake air temperature is controlled at 30-80 ℃; Atomizing pressure is controlled at 0.3-2.0bar; Protection air pressure is at 0.2-1.8bar; The hydrojet speed flowrate is controlled at 100-120 rev/min; Temperature of charge is controlled at 40-50 ℃; The hydrojet end is back to be descended dry 60-90 minute at 40-60 ℃; Technological parameter when for example preparing brain-invigorating and heart-soothing capsule is: charging temperature 40-50 ℃ time the in the equipment; The medicated powder temperature sprays cream when reaching 40-50 ℃; Air inflow in the hydrojet process is controlled at 2500-3000m
3/ h; Intake air temperature is controlled at 30～80 ℃; Atomizing pressure is controlled at 0.3-2.0bar; Protection air pressure is at 0.2-1.8bar; The hydrojet speed flowrate is controlled at 100-120 rev/min; Temperature of charge is controlled at 40-60 ℃; The hydrojet end is back to be descended dry 60-90 minute at 50-60 ℃.
The drawback that the loss of effective components that the preparation technology of Chinese medicinal capsule agent of the present invention has overcome former technology is big, moisture content control is unstable, operation is many, walk iterative process has changed original capsule preparations technology, utilizes one step of low temperature combination drying.4 procedures that this preparation technology will extract, begin after concentrating to the packing are reduced to 1 procedure, shorten man-hour half, improved one times of production capacity; Material carries out pneumatic conveying drying under 50-60 ℃ of temperature flow regime, the control of extractum relative density is low, has avoided the carbonization phenomenon, has improved the inherent quality of product; Improve finished product rate 3%, moisture content control is stable, and produces in airtight environment, has reduced opportunities for contamination, has improved first-time qualification rate.
Further describe the present invention below in conjunction with embodiment.
A kind of brain-invigorating and heart-soothing capsule, the capsule preparations that it is made up of the pure Chinese medicine of 15 flavors such as Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Pheretima, Radix Puerariae, Rhizoma Chuanxiong, Flos Carthami, have blood circulation promoting and blood stasis dispelling, promoting the circulation of QI and reducing phlegm, removing obstruction in the collateral to relieve pain function, can be used for qi depression to blood stasis, the turbid resistance network of expectorant, thoracic obstruction twinge, angor, fixing do not move, go into Night Watch very, palpitation and uneasiness, dizziness headache, and diseases such as coronary heart disease, myocardial infarction, cerebral arteriosclerosis and cerebral thrombosis, the standard foundation is the 18th of a ministry standard Chinese patent medicine preparation.
During preparation, earlier part medical material process is extracted, extracting solution is condensed into flowing soaking paste (I), and another part pulverizing medicinal materials is become fine powder, sieves to obtain powder II; The step combination drying in multi-functional coating machine with fluid extract (I) and fine powder (II) divides packing to get product again.Detailed process is as follows:
Radix Salviae Miltiorrhizae, Radix Polygoni Multiflori, Fructus Lycii, Radix Paeoniae Rubra, Radix Puerariae and Pheretima Six-element medical material are added the water steaming and decocting 3 times, each time was followed successively by 3,2,1 hours, each amount of water is 8,6,5 times of primary dose, gradation is filtered, filtrate merges, filtrate is concentrated into the triple effect concentration tank and is flowing soaking paste and obtains (I), and relative density is 1.21 ± 0.4 under 70 ℃, and temperature is 70 ℃; Another part is comprised that Rhizoma Alismatis, Rhizoma Anemones Altaicae, Rhizoma Chuanxiong, Flos Carthami, Radix Achyranthis Bidentatae, Radix Curcumae, Semen Ziziphi Spinosae, Radix Glycyrrhizae, Radix Polygalae etc. nine flavor medical materials obtain powder (II) through pulverizing, sieve, mixing; Fluid extract (I) and powder (II) are gone on foot mixing, drying with multi-functional coating machine one, medicated powder capsule filler filling, packing gets product.The technology of a described step combination drying was achieved in that the equipment preheating 20 minutes, charging when temperature in the equipment reaches 40～50 ℃; Preheating is 5 minutes after the charging, sprays cream when the medicated powder temperature reaches 40-50 ℃; Air inflow in the hydrojet process is controlled at 2500-3000m
3/ h, intake air temperature is controlled at 30-80 ℃, and atomizing pressure is controlled at 0.3-2.0bar; Protection air pressure is at 0.2-1.8bar, and the hydrojet speed flowrate is controlled at 100-120 rev/min, and temperature of charge is controlled at 40-50 ℃, hydrojet finish the back 50-60 ℃ dry 60-90 minute down, at this moment, atomizing pressure and protection air pressure transfer to below the 0.5bar.
Claims (4)
1, a kind of preparation technology of Chinese medicinal capsule agent is characterized in that comprising part medical material process is extracted that extracting solution is condensed into flowing soaking paste (I), and other part pulverizing medicinal materials is become fine powder, and sieving obtains powder II; With fluid extract (I) and fine powder (II) step combination drying, divide packing to get product again.
2, the preparation technology of Chinese medicinal capsule agent as claimed in claim 1, the relative density that it is characterized in that fluid extract is 1.21 ± 0.4 under 70 ℃.
3, the preparation technology of Chinese medicinal capsule agent as claimed in claim 1 is characterized in that the temperature of a step combination drying of described fluid extract and fine powder is 40-70 ℃.
4, the preparation technology of Chinese medicinal capsule agent as claimed in claim 1 is characterized in that a step combination drying of described fluid extract and fine powder carries out in multi-functional coating machine, concrete technological parameter is respectively: charging temperature 40-50 ℃ time the in the equipment; The medicated powder temperature sprays cream when reaching 40-50 ℃; Air inflow in the hydrojet process is controlled at 2500-3000m
3/ h; Intake air temperature is controlled at 30-80 ℃; Atomizing pressure is controlled at 0.30-2.0bar; Protection air pressure is at 0.2-1.8bar; The hydrojet speed flowrate is controlled at 100-120 rev/min; Temperature of charge is controlled at 40-60 ℃; The hydrojet end is back to be descended dry 60-90 minute at 40-60 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99126334 CN1259344A (en) | 1999-12-16 | 1999-12-16 | Prepn. technique for Chinese traditional medicine capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99126334 CN1259344A (en) | 1999-12-16 | 1999-12-16 | Prepn. technique for Chinese traditional medicine capsule |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1259344A true CN1259344A (en) | 2000-07-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99126334 Pending CN1259344A (en) | 1999-12-16 | 1999-12-16 | Prepn. technique for Chinese traditional medicine capsule |
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| CN (1) | CN1259344A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269203B (en) * | 2008-05-07 | 2010-12-22 | 吉林敖东延边药业股份有限公司 | Quality control testing method for brain-invigorating and heart-soothing capsule |
| CN101596298B (en) * | 2008-06-02 | 2011-09-28 | 北京亚东生物制药有限公司 | Traditional Chinese drop pills for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN103751622A (en) * | 2014-02-13 | 2014-04-30 | 姜吉双 | Pharmaceutical composition for treating coronary heart disease |
| CN110613772A (en) * | 2019-10-31 | 2019-12-27 | 无锡济民可信山禾药业股份有限公司 | Quick-release tablet for treating coronary heart disease and cerebral thrombosis and preparation method thereof |
| CN115814039A (en) * | 2022-02-09 | 2023-03-21 | 吉林省正和药业集团股份有限公司 | Xinnaokang capsule and large-batch and efficient preparation method thereof |
-
1999
- 1999-12-16 CN CN 99126334 patent/CN1259344A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101269203B (en) * | 2008-05-07 | 2010-12-22 | 吉林敖东延边药业股份有限公司 | Quality control testing method for brain-invigorating and heart-soothing capsule |
| CN101596298B (en) * | 2008-06-02 | 2011-09-28 | 北京亚东生物制药有限公司 | Traditional Chinese drop pills for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN103751622A (en) * | 2014-02-13 | 2014-04-30 | 姜吉双 | Pharmaceutical composition for treating coronary heart disease |
| CN103751622B (en) * | 2014-02-13 | 2016-02-03 | 姜吉双 | A kind of pharmaceutical composition for the treatment of coronary heart disease |
| CN110613772A (en) * | 2019-10-31 | 2019-12-27 | 无锡济民可信山禾药业股份有限公司 | Quick-release tablet for treating coronary heart disease and cerebral thrombosis and preparation method thereof |
| CN115814039A (en) * | 2022-02-09 | 2023-03-21 | 吉林省正和药业集团股份有限公司 | Xinnaokang capsule and large-batch and efficient preparation method thereof |
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| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |