CN1253145C - Blood sugar reducing skin-care cream specially for curing diabetes and its producing method - Google Patents
Blood sugar reducing skin-care cream specially for curing diabetes and its producing method Download PDFInfo
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- CN1253145C CN1253145C CN 02137658 CN02137658A CN1253145C CN 1253145 C CN1253145 C CN 1253145C CN 02137658 CN02137658 CN 02137658 CN 02137658 A CN02137658 A CN 02137658A CN 1253145 C CN1253145 C CN 1253145C
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Abstract
The present invention relates to a skin care cream used for reducing the blood sugar of patients suffering from noninsulin-dependent diabetes mellitus and the technical field of a production method thereof. The skin care cream comprises skin care cream radical, and is characterized in that the skin care cream radical is used as a carrier, and drug ingredients which treat diabetes and reduce blood sugar are added through skin penetrating components, for example, the skin care cream radical comprises suifonylurea medicines of reducing blood sugar, of which the mass percentage is 0.1% to 2.8%, or/and biguanide medicines of reducing blood sugar, of which the mass percentage is 0.1% to 2.8%, or/and insulin secretion promoting agent medicines of reducing blood sugar, of which the mass percentage is 0.06% to 1.6%, or/and plant/ traditional Chinese medicine extract of which the mass percentage is 0.2% to 8% and skin penetrating components of which the mass percentage is 1% to 10%. Simultaneously, the present invention also provides a production method for producing the skin care cream. The present invention has the advantages of reliable and safe treatment, easy use, ideal effect and face beautification; when the present invention is used for long term, the present invention can strengthen the ability of in vivo insulin for regulating blood sugar, can reduce the blood sugar of patients suffering from diabetes mellitus, has the effect of treating diabetes mellitus, and is especially suitable for old patients and female patients to use.
Description
Technical field
The present invention relates to a kind ofly be used for treating the blood sugar reducing skin-care cream of diabetes and the technical field of its production method for the diabetes patient special use.
Background technology
Diabetes are the 3rd the lethal disease that disables after cancer, cardiovascular disease, have every year in the world and go into to die from diabetes more 2,800 ten thousand, and the whole world spends money in diabetes every year up to 1,600 hundred million dollars and cumulative year after year.Update shows that China's diabetics surpasses 5,000 ten thousand, accounts for 1/5 of global diabetics.The annual number of the infected of existing China diabetes surpasses 3,000 ten thousand people, and 10 years from now on diabetes of scholarly forecast will increase fast at the sickness rate of China, might reach about 14%.It is that insulin-dependent and II type are non-insulin-depending type that diabetes mainly are divided into the I type.In the diabetics of having diagnosed, about 90% is type ii diabetes.Up to the present, diabetes still can't be cured.To type i diabetes, have only at present by insulin injection and treat.To type ii diabetes, the medicine that is used for the treatment of at present has following several: sulfonylureas, biguanide antidiabetic medicament, alpha-glucosidase inhibitor, Drugs Promoting Insulin Secretion, euglycemic agent, insulin injection treatment.
The sulfonylurea hypoglycemic agent thing can stimulate the pancreatic excreting insulin, stimulates the effect of Insulin receptor INSR in the peripheral nerve tissue, increases Insulin receptor INSR number and affinity thereof, reduces glycogen output.Because characteristics such as second filial generation sulfonylurea hypoglycemic agent thing is stronger than first generation medicine blood sugar reducing function, crash rate is low, so, now commonly used on the market is second filial generation sulfonylurea hypoglycemic agent thing, is followed successively by glyburide, glipizide, diamicron, gliquidone by the power of its blood sugar reducing function.
(1) glyburide: claim glibenclamide, Ge Liehe element again.This medical instrument has the characteristics that dosage is little, effect is fast, curative effect is high, duration of efficacy is long.Take the back and begin to bring into play blood sugar reducing function after 15～20 minutes, the half-life is 10～16 hours, and sustainable 24 hours of action time, metabolite respectively accounts for about 50% through bile and kidney discharge.Should take in half an hour ante cibum.But this medicine has certain danger for patient that hepatic and kidney function obstacle is arranged and the side effect that the gerontal patient produced more than 60 years old, and hypoglycemia easily takes place period in a medicine.
(2) Glipizide: the another name glidiazinamide claims glipizide, glipizide, Glipizide XL again.Have absorb rapidly, blood sugar reducing function is obvious, especially to reducing post-prandial glycemia, producing the dangerous few advantage of hypoglycemia.Take after 30 minutes blood glucose and begin to descend, the half-life is short to be about 2～4 hours, can continuous action in blood 10 hours, and this medicine 97% is discharged from kidney.But this medicine requires full wafer to swallow, and should not chew and break into two with one's hands and take, and should not use suffering from serious gastrointestinal disease person.
(3) diamicron: claim gliclazide, gliclazide again.This medicine can be regulated carbohydrate metabolism, improves the effect of diabetic microvascular complication.Half-life is 10～12 hours.60%～70% from renal excretion behind liver metabolism, and 10%～20% drains from gastrointestinal tract.But the side effect that this medicine old people uses the back to be produced has danger, and consumption should be less than normal; And diuretic, barbiturates etc. can reduce the activity of this medicine.
(4) gliquidone: claim gliquidone, Gliguidone again.This medicine is short action time, and the half-life only is 1.3～1.5 hours, and sustainable 8 hours of blood sugar reducing function can be avoided hyperinsulinemia, rare hypoglycemia, and not from kidney from bile excretion.But this medicine is to diabetic coma, ketoacidosis, have certain danger to sulfa drugs allergy sufferers, gestation and late stage uremia patient.
Biguanide antidiabetic medicament can suppress the absorption of glucose from intestinal, increases the utilization of surrounding tissue to glucose, increases the anerobic glycolysis of glucose in the muscular tissue, suppresses the output of glycogen heteroplasia and glycogen, and increases the sensitivity to insulin.China's metformin in the market claims metformin, metformin hydrochloride gastric soluble tablet, glucophage, Dimethyldiguanide hydrochloride enteric solubility tablet again.The effect of this medicine than phenformin a little less than, more obvious to fat and non-obese patient is all effective to the type 2 diabetes mellitus patient of obesity, take for a long time and can also lose weight, half-life stomach 1.7～4.5 hours, drug effect continues 5～6 hours, and is most of by renal excretion.But the renal insufficiency that this medicine causes a variety of causes, glomerule were considered rate less than 20ml/min person, metformin hydrochloride allergy sufferers, acute and chronic metabolism poisoner are had certain danger; The metformin blood plasma level easily brings out lactic acidosis during greater than 5 μ g/ml.
Alpha-glucosidase inhibitor is the novel hypoglycemic medicine of a class, and the Alpha-glucosidase inhibitor of present domestic sale is to be produced by Bayer A.G, and chemical name is an acarbose, and commodity are called acarbose, and dosage is every 50mg.The alpha-glucosidase on this medicine competitive inhibition intestinal epithelial cell surface in intestinal, thus carbohydrate absorption prolonged, alleviate postprandial hyperglycemia.This medicine can be used as diabetics and the impaired glucose tolerance person uses.When beginning to have meal and several leading mouthful meal chew simultaneously and swallow, be approximately 4～6 hours with the bonded time of alpha-glucosidase.But this medicine to infection, malignant tumor, excessive drinking, originally digest and assimilate bad, hepatic disfunction person and have certain danger.The severe renal function person of going down, and when taking digestant enzyme preparation, should not adopt this medicine.As share post-prandial glycemia is more reduced, and make the gastrointestinal side effect aggravation of this medicine with neomycin.
Voglibose: having another name called doubly glad is α glycosidase inhibitor of new generation.It is crossed and optionally competes the effect that the antagonism form reaches the inhibition alpha-glucosidase.Be to improve the postprandial hyperglycemia level clinically by delaying digesting and assimilating of sugar.But this medicine has certain danger to severe infections, severe trauma, serious liver, renal function injury and allergies person etc. are arranged.Share with other medicines and to have hypoglycemia and occur.
In sum, the onset diabetes rate increases fast in China at present, and the drug effect and the mechanism of action of various kinds of drug have nothing in common with each other, and not all patient can come disease controlling with oral drugs for diabetics.Oral hypoglycemic thing blood sugar lowering promptly has irreversible danger as having side effects, thereby to the certain danger of the especially more old patient's tool of many patients.
Chinese patent has many reports to the technology of protective skin cream in addition, as the patent No. is that 00132722.4 " skin-care and treatment cream ", the patent No. are 00132722.4 " skin-care and treatment cream ", but their therapeutical effect concentrate on the U.S. face effect of general beauty treatment, and the treatment of diabetes effect is not but reported.
Summary of the invention
It is to provide a kind of blood sugar reducing skin-care cream for the treatment of diabetes at prior art that the present invention will solve primary technical problem, it can make for the type ii diabetes people and be used for treating diabetes, and some drawbacks of solution oral hypoglycemic thing, as have side effects and promptly have irreversible danger, old patient is had potential danger more, and easy to use and curative effect is reliable, safety, plays the skin care effect of the U.S. face of certain beauty treatment simultaneously.
Another technical problem to be solved by this invention provides the method for producing above-mentioned blood sugar reducing skin-care cream, and its method is simple, implements easily.
The present invention solves the technical scheme that above-mentioned primary technical problem adopts: a kind of blood sugar reducing skin-care cream for the treatment of diabetes, it includes the protective skin cream base, it is characterized in that the protective skin cream base as carrier, and contain the pharmaceutical compositions of the treatment diabetes blood sugar lowering of skin transdermal component and adding.
Contain in the above-mentioned protective skin cream base 0.1-2.8% mass percent the sulfonylurea hypoglycemic agent thing or/and the biguanide antidiabetic medicament of 0.1-2.8% mass percent or/and the Drugs Promoting Insulin Secretion hypoglycemic medicine of 0.06-1.6% mass percent or/and the plant extract of 0.2-8% mass percent or Chinese medicine extract and 1-10% mass percent transdermal component, above-mentioned plant extract is the edible fungi extract, panax ginseng extractum, or Bulbus Allii essence, above-mentioned Chinese medicine extract is to select Flos Chrysanthemi for use, Radix Et Rhizoma Rhei, Radix Trichosanthis, Fructus Crataegi, Radix Astragali, Poria, Fructus Lycii, Semen Persicae, Flos Carthami, Herb Gynostemmae Pentaphylli, Folium Ginkgo, Bombyx Batryticatus, Radix Curcumae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Radix Puerariae, Rhizoma Dioscoreae, Hulless oate, high strange fruit, Radix Puerariae, wheat germ or Cortex Cinnamomi, carry out compatibility according to Chinese medicine determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle, in aqueous systems, extract and the extract that obtains.
Above-mentioned sulfonylurea hypoglycemic agent thing preferred content is the 0.6-2% mass percent, can select glibenclamide or glidiazinamide, gliclazide or gliquidone and their mixture thereof for use.
Above-mentioned biguanide antidiabetic medicament preferred content is the 0.4-1.5% mass percent, can select metformin hydrochloride or phenformin and their mixture thereof for use.
Above-mentioned Drugs Promoting Insulin Secretion hypoglycemic medicine preferred content is the 0.2-1.0% mass percent, can select repaglinide and their mixture thereof for use.
Above-mentioned plant extract or Chinese medicine extract preferred content are the 0.6-5% mass percent.
Above-mentioned transdermal component preferred content is 2-6%, can select ethanol, benzyl alcohol, phenethanol or acetone for use.
Above-mentioned white base contains surfactant such as soil temperature-20 or/and triethanolamine; The Natural antioxidant such as dibenzylatiooluene BHT are or/and vitamin E; Antiseptic such as sodium benzoate are or/and benzoic acid potassium; Vitamin C; Or at the bottom of the skin reduce wrinkle cosmetic cream of selling on the market.
The technical scheme that another technical problem to be solved by this invention adopts is: this production blood sugar reducing skin-care cream method is characterized in that step is: (1) dissolving step; The described raw material of claim 1 is divided into water raw material that can be dissolved in aqueous phase and the organic solvent raw material that can be dissolved in the organic solvent, be dissolved in water raw material and organic solvent raw material in the hot water respectively and organic solvent in, their mixed process is to carry out at a certain temperature, and its temperature range is at 50-95 degree centigrade; (2) blend step; Above-mentioned water raw material is mixed into emulsified state at a certain temperature with the organic solvent raw material, and its temperature range is at 40-90 degree centigrade; (3) the paste goods form step; Constantly stirring formation paste goods under the cooling condition, reduce to 5-30 degree centigrade of scope.
Its preferred temperature 60--85 of above-mentioned dissolving step degree centigrade; Its preferred temperature 50-80 of blend step degree centigrade; The paste goods form preferred temperature 14-25 degree centigrade of step.
Compared with prior art, the advantage of this reality invention is: 1, safety in utilization is strong, because this blood sugar lowering protective skin cream is to use on skin, rely on the absorption of skin to permeate blood sugar lowering, so effect relatively relaxes and is lasting, after in case untoward reaction and side effect occurring, can rinse out the blood sugar lowering protective skin cream on the skin at once, prevent the further expansion of side effect, so the drawback that oral drugs can't reverse can not appear, and more secure and reliable to use to senile patient or multiple disease patient; 2, curative effect is reliable, has adopted the endo-medicine of multiple treatment diabetes, and in conjunction with Chinese herb medicine and plant essence, blending the east and the west, to take a tonic or nourishing food to build up one's health and the treatment combination, effect is desirable more, is fit to treatment type ii diabetes people; 3, use is very convenient, needs only before 1-2 hour before the meal, the blood sugar lowering frost is coated at any position of health just can, be coated with after just produced blood sugar decreasing effect in 1-2 hour, whole process can remain on 7 hours, if blood glucose was reduced to low degree in the body, rinses out just passable at once; 4, the effect that has the U.S. face of beauty treatment simultaneously makes skin fine and smooth and smooth away wrinkles, and very suitable old people and female health 5, production method are simple, produce easily and implement, and need not substantial equipment.Comprehensive above-mentioned novel transdermal blood sugar lowering external/coating blood sugar reducing skin-care cream, its similar vanishing cream, be called for short " blood sugar lowering frost ", can be used to reduce non-insulin-dependent diabetes mellitus people's blood glucose, while tool skin care effect, being particularly suitable for the non-insulin-dependent diabetes mellitus people uses, II type (non-insulin-depending type) diabetes there is the body fluid of reduction blood glucose effect, have simultaneously reduce at short notice body fluid blood glucose and chronicity improve beta cell to the response of glucose and insulin to effects such as combine of destination organization, can strengthen the regulating power of the interior insulin of body to blood glucose.
The specific embodiment
Below in conjunction with embodiment the present invention is described in further detail.
Embodiment 1:
Take off the row material by mass percentage:
1) glidiazinamide 1.92%
2) metformin hydrochloride 0.3%
3) vitamin E 0.4%
4) mono-stearin 1.2%
5) stearic acid 10%
6) dehydrated alcohol 1.8%
7) glycerol 7.2%
8) methyl hydroxybenzoate 0.04%
9) paraffin wax 1.6%
10) triethanolamine 0.3%
11) sodium benzoate 0.08%
12) panax ginseng extractum (commercially available) 0.8%
13) Bulbus Allii essence (commercially available) 0.7%
14) vitamin C 0.6%
15) soil temperature-20 0.2%
16) spice 0.5%
17) distilled water to 100%
Respectively above-mentioned raw materials 1-9 and 10-17 are heated to 80 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 20 degrees centigrade in 70 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 2
Take off the row material by mass percentage:
1) gliclazide 1.3%
2) phenformin 0.8%
3) vitamin E 0.3%
4) repaglinide 0.6%
5) stearic acid 10%
6) dehydrated alcohol 3%
7) glycerol 7%
8) methyl hydroxybenzoate 0.04%
9) paraffin wax 1.6%
10) triethanolamine 0.3%
11) sodium benzoate 0.08%
12) panax ginseng extractum (commercially available) 0.7%
13) Bulbus Allii essence (commercially available) 1.8%
14) vitamin C 0.6%
15) soil temperature-20 0.2%
16) spice 0.5%
17) distilled water to 100%
Respectively above-mentioned raw materials 1-9 and 10-17 are heated to 95 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 30 degrees centigrade in 90 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 3
Take off the row material by mass percentage:
1) gliclazide 0.6%
2) glibenclamide 0.7%
3) phenformin 0.8%
4) vitamin E 0.3%
5) repaglinide 1.0%
6) stearic acid 10%
7) phenethanol 2%
8) glycerol 7%
9) methyl hydroxybenzoate 0.04%
10) paraffin wax 1.6%
11) triethanolamine 0.3%
12) sodium benzoate 0.08%
13) panax ginseng extractum (commercially available) 2%
14) Bulbus Allii essence (commercially available) 3%
15) vitamin C 0.6%
16) soil temperature-20 0.2%
17) spice 0.5%
18) distilled water to 100%
Respectively above-mentioned raw materials 1-10 and 11-18 are heated to 50 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 5 degrees centigrade in 40 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 4:
Take off the row material by mass percentage:
1) glidiazinamide 2.0%
2) metformin hydrochloride 0.4%
3) repaglinide 0.2%
4) vitamin E 0.4%
5) mono-stearin 1.2%
6) stearic acid 10%
7) benzyl alcohol 1.8%
8) glycerol 7.2%
9) methyl hydroxybenzoate 0.04%
10) paraffin wax 1.6%
11) triethanolamine 0.3%
12) sodium benzoate 0.08%
13) panax ginseng extractum (commercially available) 4%
14) Bulbus Allii essence (commercially available) 4%
15) vitamin C 0.6%
16) soil temperature-20 0.2%
17) spice 0.5%
18) distilled water to 100%
Respectively above-mentioned raw materials 1-10 and 11-18 are heated to 80 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 20 degrees centigrade in 70 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 5:
Take off the row material by mass percentage:
1) glidiazinamide 0.6%
2) phenformin 0.7%
3) metformin hydrochloride 0.8%
4) repaglinide 1%
5) vitamin E 0.4%
6) mono-stearin 1.2%
7) stearic acid 10%
8) dehydrated alcohol 4%
9) glycerol 7.2%
10) methyl hydroxybenzoate 0.04%
11) paraffin wax 1.6%
12) triethanolamine 0.3%
13) sodium benzoate 0.08%
14) panax ginseng extractum (commercially available) 0.3%
15) Bulbus Allii essence (commercially available) 0.3%
16) vitamin C 0.6%
17) soil temperature-20 0.2%
18) spice 0.5%
19) distilled water to 100%
Respectively above-mentioned raw materials 1-11 and 12-18 are heated to 85 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 25 degrees centigrade in 80 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 6:
Take off the row material by mass percentage:
1) glidiazinamide 2.8%
2) metformin hydrochloride 0.1%
3) repaglinide 0.06%
4) vitamin E 0.4%
5) mono-stearin 1.2%
6) stearic acid 10%
7) dehydrated alcohol 6%
8) glycerol 7.2%
9) methyl hydroxybenzoate 0.04%
10) paraffin wax 1.6%
11) triethanolamine 0.3%
12) sodium benzoate 0.08%
13) panax ginseng extractum (commercially available) 0.8%
14) Bulbus Allii essence (commercially available) 0.7%
15) vitamin C 0.6%
16) soil temperature-20 0.2%
17) spice 0.5%
18) distilled water to 100%
Respectively above-mentioned raw materials 1-10 and 11-18 are heated to 85 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 25 degrees centigrade in 80 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 7:
Take off the row material by mass percentage:
1) gliquidone 0.1%
2) metformin hydrochloride 2.8%
3) repaglinide 1.6%
4) vitamin E 0.4%
5) mono-stearin 1.2%
6) stearic acid 10%
7) dehydrated alcohol 2%
8) glycerol 7.2%
9) methyl hydroxybenzoate 0.04%
10) paraffin wax 1.6%
11) triethanolamine 0.3%
12) sodium benzoate 0.08%
13) panax ginseng extractum (commercially available) 0.8%
14) Bulbus Allii essence (commercially available) 0.7%
15) vitamin C 0.6%
16) soil temperature-20 0.2%
17) spice 0.5%
18) distilled water to 100%
Respectively above-mentioned raw materials 1-10 and 11-18 are heated to 60 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 14 degrees centigrade in 50 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 8:
Take off the row material by mass percentage:
1) glidiazinamide 2.8%
2) vitamin E 0.4%
3) mono-stearin 1.2%
4) stearic acid 10%
5) acetone 3%
6) glycerol 7.2%
7) methyl hydroxybenzoate 0.04%
8) paraffin wax 1.6%
9) triethanolamine 0.3%
10) sodium benzoate 0.08%
11) panax ginseng extractum (commercially available) 0.2%
12) vitamin C 0.6%
13) soil temperature-20 0.2%
14) spice 0.5%
15) distilled water to 100%
Respectively above-mentioned raw materials 1-8 and 9-15 are heated to 80 degrees centigrade of dissolvings, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 20 degrees centigrade in 70 degrees centigrade of mixed down and rapid stirrings of temperature.
Embodiment 9
Take off the row material by mass percentage:
1) gliclazide 1.3%
2) phenformin 0.8%
3) vitamin E 0.3%
4) repaglinide 0.6%
5) stearic acid 10%
6) dehydrated alcohol 3%
7) glycerol 7%
8) methyl hydroxybenzoate 0.04%
9) paraffin wax 1.6%
10) triethanolamine 0.3%
11) sodium benzoate 0.08%
12) the compound Chinese medicine extract 3.5%
13) vitamin C 0.6%
14) soil temperature-20 0.2%
15) spice 0.5%
16) distilled water to 100%
The compound Chinese medicine extract can extract in aqueous systems with traditional water-soluble substances extracting method after treating the Chinese herbal medicine compatibility of diabetes, can contain the alcoholic organic solvent of 5-30% mass percent in the extraction system, to improve extraction effect.Here Chinese herbal medicine can be selected for use: Flos Chrysanthemi, Radix Et Rhizoma Rhei, Radix Trichosanthis, Fructus Crataegi, Radix Astragali, Poria, Fructus Lycii, Semen Persicae, Flos Carthami, Herb Gynostemmae Pentaphylli, Folium Ginkgo, Bombyx Batryticatus, Radix Curcumae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Radix Puerariae, Rhizoma Dioscoreae, Hulless oate, high strange fruit, Radix Puerariae,, wheat germ, Cortex Cinnamomi etc., carry out compatibility according to Chinese medicine determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle, as: 2 parts of Flos Chrysanthemis, 1 part of Radix Et Rhizoma Rhei, 2 parts of Radix Trichosanthis, 2 parts of Fructus Crataegis, 1 part of Radix Astragali, Herb Gynostemmae Pentaphylli carry out compatibility for 1 part.
Respectively above-mentioned raw materials 1-9 and 10-16 are heated to 95 degrees centigrade of dissolvings then, then form emulsification system, under the cooling condition, continue to stir formation paste goods, until 30 degrees centigrade in 90 degrees centigrade of mixed down and rapid stirrings of temperature.
Claims (11)
1, a kind of blood sugar reducing skin-care cream for the treatment of diabetes, it includes the protective skin cream base, it is characterized in that the protective skin cream base as carrier, and contains the pharmaceutical compositions of the treatment diabetes blood sugar lowering of skin transdermal component and adding.
2, blood sugar reducing skin-care cream according to claim 1, it is characterized in that described pharmaceutical compositions be the 0.1-2.8% mass percent the sulfonylurea hypoglycemic agent thing or/and the biguanide antidiabetic medicament of 0.1-2.8% mass percent or/and the Drugs Promoting Insulin Secretion hypoglycemic medicine of 0.06-1.6% mass percent or/and the plant extract of 0.2-8% mass percent or Chinese medicine extract, above-mentioned plant extract is a panax ginseng extractum, or Bulbus Allii essence, above-mentioned Chinese medicine extract is to select Flos Chrysanthemi for use, Radix Et Rhizoma Rhei, Radix Trichosanthis, Fructus Crataegi, Radix Astragali, Poria, Fructus Lycii, Semen Persicae, Flos Carthami, Herb Gynostemmae Pentaphylli, Folium Ginkgo, Bombyx Batryticatus, Radix Curcumae, Rhizoma Coptidis, Radix Salviae Miltiorrhizae, Radix Puerariae, Rhizoma Dioscoreae, Hulless oate, high strange fruit, Radix Puerariae, wheat germ or Cortex Cinnamomi, carry out compatibility according to Chinese medicine determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs principle, in aqueous systems, extract and the extract that obtains.
3, blood sugar reducing skin-care cream according to claim 2 is characterized in that described skin transdermal constituent content is the 1-10% mass percent.
4, blood sugar reducing skin-care cream according to claim 2 is characterized in that described sulfonylurea hypoglycemic agent thing content is the 0.6-2% mass percent, selects glibenclamide or glidiazinamide, gliclazide, gliquidone or their mixture for use.
5, blood sugar reducing skin-care cream according to claim 2 is characterized in that described biguanide antidiabetic medicament content is the 0.4-1.5% mass percent, selects metformin hydrochloride or phenformin and their mixture thereof for use.
6, blood sugar lowering protective skin cream according to claim 2 is characterized in that described Drugs Promoting Insulin Secretion hypoglycemic medicine content is the 0.2-1.0% mass percent, selects repaglinide for use.
7, blood sugar reducing skin-care cream according to claim 2 is characterized in that described plant extract or Chinese medicine extract content are the 0.6-5% mass percent.
8, blood sugar reducing skin-care cream according to claim 2 is characterized in that described transdermal constituent content is the 2-6% mass percent, selects ethanol, benzyl alcohol, phenethanol or acetone for use.
9, blood sugar reducing skin-care cream according to claim 2 is characterized in that described white base contains surfactant soil temperature-20 or triethanolamine; Natural antioxidant dibenzylatiooluene or vitamin E; Antiseptic sodium benzoate or benzoic acid potassium; Vitamin C.
10, the method for the described blood sugar reducing skin-care cream of a kind of production claim 1 is characterized in that step is:
(1) dissolving step; The described raw material of claim 1 is divided into water raw material that can be dissolved in aqueous phase and the organic solvent raw material that can be dissolved in the organic solvent, be dissolved in water raw material and organic solvent raw material in the hot water respectively and organic solvent in, their mixed process is to carry out at a certain temperature, and its temperature range is at 50-95 degree centigrade;
(2) blend step; Above-mentioned water raw material is mixed into emulsified state at a certain temperature with the organic solvent raw material, and its temperature range is at 40-90 degree centigrade;
(3) the paste goods form step; Constantly stirring formation paste goods under the cooling condition, reduce to 5-30 degree centigrade of scope.
11, method according to claim 10,60-85 degree centigrade of its temperature of the described dissolving step of its feature; 50-80 degree centigrade of its temperature of blend step; The paste goods form 14-25 degree centigrade of step temperature.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02137658 CN1253145C (en) | 2002-10-25 | 2002-10-25 | Blood sugar reducing skin-care cream specially for curing diabetes and its producing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02137658 CN1253145C (en) | 2002-10-25 | 2002-10-25 | Blood sugar reducing skin-care cream specially for curing diabetes and its producing method |
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| Publication Number | Publication Date |
|---|---|
| CN1491639A CN1491639A (en) | 2004-04-28 |
| CN1253145C true CN1253145C (en) | 2006-04-26 |
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| AU2011257964B2 (en) | 2010-05-24 | 2014-10-30 | Ozstar Therapeutics Pty Ltd | Anti-diabetic compositions and methods |
| CN107982208B (en) * | 2017-12-20 | 2021-06-08 | 江苏山信药业有限公司 | Metformin hydrochloride cream and preparation method thereof |
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2002
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