CN1251662C - Low temp method for concentrating extracting solution of Chinese herbal medicine and its devices - Google Patents
Low temp method for concentrating extracting solution of Chinese herbal medicine and its devices Download PDFInfo
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- CN1251662C CN1251662C CN 03113710 CN03113710A CN1251662C CN 1251662 C CN1251662 C CN 1251662C CN 03113710 CN03113710 CN 03113710 CN 03113710 A CN03113710 A CN 03113710A CN 1251662 C CN1251662 C CN 1251662C
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- 238000000034 method Methods 0.000 title claims abstract description 30
- 241000411851 herbal medicine Species 0.000 title 1
- 239000007788 liquid Substances 0.000 claims abstract description 51
- 239000003814 drug Substances 0.000 claims abstract description 28
- 239000013078 crystal Substances 0.000 claims abstract description 17
- 238000000605 extraction Methods 0.000 claims abstract description 17
- 238000004781 supercooling Methods 0.000 claims abstract description 6
- 239000002904 solvent Substances 0.000 claims abstract description 4
- 238000005057 refrigeration Methods 0.000 claims description 17
- 239000002002 slurry Substances 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 238000002604 ultrasonography Methods 0.000 claims description 4
- 238000007689 inspection Methods 0.000 claims description 3
- 230000007704 transition Effects 0.000 claims description 3
- 238000009529 body temperature measurement Methods 0.000 claims description 2
- 238000005265 energy consumption Methods 0.000 abstract description 2
- 238000005119 centrifugation Methods 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 description 11
- 230000008025 crystallization Effects 0.000 description 10
- 238000005516 engineering process Methods 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 7
- 239000000047 product Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000020477 pH reduction Effects 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000004939 coking Methods 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000004134 energy conservation Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000003252 repetitive effect Effects 0.000 description 1
- 239000010865 sewage Substances 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
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Abstract
The present invention belongs to the field of medicine and sanitation, which discloses a cryoconcentration method of traditional Chinese medicine extraction liquid and a device for the cryoconcentration method. In the method, the traditional Chinese medicine extraction liquid achieves a supercooling temperature, and then, a physical means is used for causing a supercooled solution to continuously generate ice crystals; solvents clamped in the ice crystals are separated from solute by centrifugation. The method of the present invention can improve the product quality of traditional Chinese medicine and the extraction yield of the traditional Chinese medicine, and reduce the energy consumption of products.
Description
Technical field
The invention belongs to pharmaceutical sanitary field, specifically relate to a kind of cryoconcentration method and device thereof of Chinese medicine extraction liquid.
Background technology
The extraction of herbal pharmaceutical, separation, purification technique recent two decades have had very big variation, but compare with external advanced pharmaceutical industry, and gap is still very big.Method for concentration existing and that Chinese medicine adopts generally adopts the boiling of negative pressure steam, volatile material condensation is got rid of, thereby reached the medicinal liquid concentrated effect.There is the disadvantage that is difficult to overcome in this technical method in actual production: volatile component loss in the medicinal liquid; Production environment is poor, because a large amount of steam and medicinal liquid volatility thing steam cause the production scene flavour of a drug extremely dense; Medicinal liquid produces phenomenons such as coking, cohesion in the heating concentration process; Have the saccharide acidification reaction, the final products mouthfeel is poor; Energy consumption is big, the wasting of resources etc.
Crystallization Separation and purification technique are extensive in the modern chemical industry sector application, aspects such as particularly abroad, its application has related to that concentration of juices, milk concentrate, desalinization and sewage disposal.And the crystallization method for concentration is applied in upward extraction Chinese medicine ingredients of production, and the difficulty that technical existence is suitable does not still have relevant report both at home and abroad.
Summary of the invention
The object of the present invention is to provide a kind of cryoconcentration method of Chinese medicine extraction liquid;
Another object of the present invention is to provide the device of realizing said method.
The cryoconcentration method of Chinese medicine extraction liquid of the present invention, be that can the flow technology of ice crystal or ice slurry is applied in the low-temperature concentration process of herb liquid, and generate continuously, automatically or the herb liquid extract at low temperature concentration systems technology of continuous production type such as the automatic discharging of discontinuous centrifugal force in conjunction with ice crystal, replace original multiple-effect evaporation herb liquid concentration technique, solve the technical problem that exists in the prior art, final tcm product quality and the Chinese medicine extraction yield of improving reduces the product energy resource consumption.
Method of the present invention makes Chinese medicine extraction liquid reach supercooling temperature, makes over-cooled solution generate ice crystal continuously with physical means then, separates with solute by the centrifugal solvent of carrying secretly in the ice crystal that makes.
Above-mentioned supercooling temperature is determined according to the concentration of Chinese medicine extraction liquid and the dependence of its phase transition temperature by temperature-controlling system, is carried out by refrigeration system.
Above-mentioned physical means is passive or active method, as collision or ultrasound wave.
Method of the present invention can be applicable to the separation of soluble component, as desalinization, wastewater treatment etc.
A kind of device of realizing the cryoconcentration method of Chinese medicine extraction liquid of the present invention mainly comprises 3 loops:
(1) dress flow container, pump, effusion meter, cooling heat exchanger, the continuous generation of ice slurry and whizzer are in turn connected into the loop; Part connecting pipe in this loop connects heater;
(2) adorn flow container, quality inspection and cryogenic temperature control system, refrigeration system, computer temperature measurement and refrigeration system temperature control system, the continuous generation of ice slurry and whizzer and be in turn connected into the loop;
(3) cooling heat exchanger and refrigeration system connect into the loop;
Wherein adorn medicine liquid outlet is arranged on the flow container, ice slurry generates continuously and there is the ice cube outlet upper end of whizzer.
Above-mentioned pump is a centrifugal water pump.
Above-mentioned refrigeration system for well, be similar to the refrigerator refrigeration, but the cold that provides is based on mobile refrigerating medium with handpiece Water Chilling Units; Computer temperature is measured and is adopted temperature data collecting system, generally adopts T type thermocouple that measurement point is carried out temperature survey; Temperature control system can adopt the temperature-sensitive bag of feedback usefulness in the general refrigeration system, and also available temperature control software system is controlled.
The continuous production technical matters that the present invention mainly adopts outer circulation heat exchange cooling, the continuous nucleus generation of subcooled liquid, centrifugal force centrifugal separation technology to combine.According to the dependence of the concentration of wanting concentrated traditional Chinese medicine liquid and its phase transition temperature, determine the operative temperature of refrigeration system in the system, make herb liquid in flow process, be cooled to degree of supercooling.By specific nucleus production technology, make the moisture in the supercool medicinal liquid in liquid bath, generate the ice crystal that flows as methods such as vibrations or ultrasound wave, system accurately controls the growth rate and the wafer size of ice crystal by chilling temperature, with solid ice crystal and separating liquid medicine, and by centrifugal method with the separating liquid medicine of carrying secretly in the solid ice crystal.The concentration change of on-site measurement herb liquid, and control the temperature of refrigeration system successively.The sample medicinal liquid is extracted in requirement according to product design, detects the control ability of quality of liquid medicine quantizating index.The final accounting and the energy conversion efficiency of the system of improvement optimized the technological level of whole system according to the production capacity of system.
Utilize method of the present invention, can bring following beneficial effect.
(1) environmental friendliness.Because medicinal liquid is at low temperatures the moisture crystallization to be separated out, the abnormal smells from the patient that does not have evaporation and brought; And water of crystallization separates fully clean, no waste water handling problem;
(2) retention rate of effective ingredient improves 20%, and particularly volatile substances is able to complete reservation;
(3) do not have albumen, the polyreaction of polysaccharide thing concentrates the back runny plaste and is easy to drying; The acidification reaction that does not have the saccharide thing, the final products mouthfeel is good;
(4) energy-conservation: the latent heat energy of water crystallization is 1/7th of an evaporation latent heat, and the crystallization concentration technique itself is exactly a power-saving technology.
(5) this low-temperature concentration process and apparatus structure compactness are simple to operate, produce continuously, and the working environment close friend, the GMP authentication of being convenient to production technology is passed through.
Description of drawings
Fig. 1 is an installation drawing of the present invention.
Fig. 2 is the concentration of experiment medicinal liquid and the graph of a relation of crystallization temperature.
The specific embodiment
The cryoconcentration process of embodiment 1 experiment medicinal liquid
The experiment medicinal liquid contains ethanol 7%, and ethylene glycol 7%, sodium chloride 1%, polyvinyl alcohol 0.01% (mass percent), molecular weight are that 90000 polyvinyl alcohol is equivalent to hmw protein, and the solution concentration of so initial medicinal liquid is about 15%.Along with concentrating of medicinal liquid, pure ice crystal is separated, and liquor strength is increased gradually, and crystallization temperature reduces, and its corresponding relation is as shown in table 1.The concentration of medicinal liquid increases with crystallization temperature decline linear substantially as can be seen from Figure 2.
Among Fig. 1, medicinal liquid is packed in the flow container 4, make medicinal liquid reach messenger drug liquid by cooling heat exchanger 9 by centrifugal water pump 7 and effusion meter 8 and be cooled to supercooled effect, the low temperature of cooling heat exchanger 9 is supplied with by refrigeration system 10; When supercool medicinal liquid arrives continuous generation of ice slurry and whizzer 3, make supercool medicinal liquid generate ice crystal continuously by passive, active methods such as collision or ultrasound wave, ice crystal further filters in 3, separates, and by centrifugal force the solvent of carrying secretly in the ice crystal is separated with solute.Purified ice cube is separated by ice cube outlet 2, and the medicinal liquid after concentrating flows in the dress flow container 4.The herb liquid product of certified concentration enters next stage product program by medicine liquid outlet 6 packings.By the concentration in quality inspection and the cryogenic temperature control system 5 on-site measurement herb liquid containers, when concentration does not also reach the ultimate density requirement, concentration for this moment, running temperature according to the dependence between the Pressure, Concentration, Temperature of specific medicinal liquid (Fig. 2) field control refrigeration system meets final requirement up to concentration.Computer temperature is measured and refrigeration system temperature control system 1, the temperature of on-site measurement system medicinal liquid in service and the operational factor of feedback control refrigeration system.The process repetitive cycling reaches the concentrated effect that needs until final this stove herb liquid as described above.On the connecting pipe of this device, connect one or more heaters 11, occur the situation that system can not run well when preventing because of the ice crystal blocking pipe.
The relation of table 1 liquor strength and crystallization temperature
| Liquor strength (%) | The medicinal liquid crystallization temperature (℃) |
| 15 | -2.4 |
| 20 | -3.2 |
| 25 | -4.1 |
| 30 | -4.9 |
| 35 | -5.7 |
| 40 | -6.5 |
| 45 | -7.3 |
| 50 | -8.1 |
| 55 | -8.9 |
| 60 | -9.7 |
| 65 | -10.6 |
| 70 | -11.4 |
| 75 | -12.2 |
| 80 | -13.0 |
| 85 | -13.8 |
| 90 | -14.6 |
Claims (3)
1, a kind of cryoconcentration method of Chinese medicine extraction liquid is characterized in that making Chinese medicine extraction liquid to reach supercooling temperature, makes over-cooled solution generate ice crystal continuously with physical means then, separates with solute by the centrifugal solvent of carrying secretly in the ice crystal that makes simultaneously; Described supercooling temperature is determined according to the concentration of Chinese medicine extraction liquid and the dependence of its phase transition temperature by temperature-controlling system, is carried out by refrigeration system; Described physical means is a ultrasound wave.
2, a kind of device of realizing the cryoconcentration method of the described Chinese medicine extraction liquid of claim 1 is characterized in that this device mainly comprises 3 loops:
(1) dress flow container, pump, effusion meter, cooling heat exchanger, the continuous generation of ice slurry and whizzer are in turn connected into the loop; Part connecting pipe in this loop connects heater;
(2) adorn flow container, quality inspection and cryogenic temperature control system, refrigeration system, computer temperature measurement and refrigeration system temperature control system, the continuous generation of ice slurry and whizzer and be in turn connected into the loop;
(3) cooling heat exchanger and refrigeration system connect into the loop; Wherein adorn medicine liquid outlet is arranged on the flow container, ice slurry generates continuously and there is the ice cube outlet upper end of whizzer.
3, the described device of claim 2 is characterized in that described pump is a centrifugal water pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03113710 CN1251662C (en) | 2003-01-29 | 2003-01-29 | Low temp method for concentrating extracting solution of Chinese herbal medicine and its devices |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03113710 CN1251662C (en) | 2003-01-29 | 2003-01-29 | Low temp method for concentrating extracting solution of Chinese herbal medicine and its devices |
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| Publication Number | Publication Date |
|---|---|
| CN1431004A CN1431004A (en) | 2003-07-23 |
| CN1251662C true CN1251662C (en) | 2006-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 03113710 Expired - Fee Related CN1251662C (en) | 2003-01-29 | 2003-01-29 | Low temp method for concentrating extracting solution of Chinese herbal medicine and its devices |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI775943B (en) * | 2017-09-18 | 2022-09-01 | 瑞士商輝凌國際中心公司 | Process, apparatus, assembly and use of assembly for the continuous manufacture of a liquid pharmaceutical composition |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103951126A (en) * | 2014-04-10 | 2014-07-30 | 中国科学院广州能源研究所 | Apparatus for utilizing natural cold source to realize seawater desalination |
| CN114766620B (en) * | 2022-03-28 | 2024-03-22 | 天津科技大学 | Method for concentrating jujube juice solution |
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2003
- 2003-01-29 CN CN 03113710 patent/CN1251662C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI775943B (en) * | 2017-09-18 | 2022-09-01 | 瑞士商輝凌國際中心公司 | Process, apparatus, assembly and use of assembly for the continuous manufacture of a liquid pharmaceutical composition |
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| Publication number | Publication date |
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| CN1431004A (en) | 2003-07-23 |
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Assignee: Guangdong Leiting Pharmaceutical Industry Co., Ltd. Assignor: Sun Yat-sen University Contract record no.: 2010440000808 Denomination of invention: Low temp method for concentrating extracting solution of Chinese herbal medicine and its devices Granted publication date: 20060419 License type: Exclusive License Open date: 20030723 Record date: 20100613 |
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Granted publication date: 20060419 Termination date: 20130129 |