CN1250662C - Hydrophilc multi-component mixture pressure-sensitive adhesive and application thereof - Google Patents
Hydrophilc multi-component mixture pressure-sensitive adhesive and application thereof Download PDFInfo
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- CN1250662C CN1250662C CN 200410059667 CN200410059667A CN1250662C CN 1250662 C CN1250662 C CN 1250662C CN 200410059667 CN200410059667 CN 200410059667 CN 200410059667 A CN200410059667 A CN 200410059667A CN 1250662 C CN1250662 C CN 1250662C
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Abstract
The present invention relates to a blending hydrophilic multicomponent mixture pressure sensitive adhesive and an application thereof. The blending hydrophilic multicomponent mixture pressure-sensitive adhesive of the present invention a blending material formed by high molecular weight hydrophilic polymers, medium molecular weight polymers and low molecular number water-soluble plasticizing agents, wherein the medium molecular weight polymers and the low molecular number water-soluble plasticizing agents can form hydrogen bonds with the high molecular weight hydrophilic polymers; because of a hydrogen bond cross-linked network and an interpenetration hydrogen bond cross-linked network formed among the three kinds of materials, the blending material has good pressure sensitive adhesive performance and cohesive force under the existence of a proper quantity of water, and has the characteristics of hydrogel water absorption and elasticity. The pressure sensitive adhesive of the present invention can be used for cutaneous penetration systems, iontophoresis treatment systems, bioelectrodes, wound treatment, skin maintenance and cosmetics. When used as adhesion materials for the skin or other body surfaces, the blending hydrophilic multicomponent mixture pressure-sensitive adhesive of the present invention simultaneously has the functions of medicine storage and medicine release control. The blending hydrophilic multicomponent mixture pressure-sensitive adhesive of the present invention can also be used for preparing adhesion paster used in other aspects.
Description
Technical field
The present invention relates to a class wetting ability multicomponent mixture pressure sensitive adhesive and an application thereof, belong to the hydrophilic pressure sensitive adhesive technology.Be the hydrophilic polymer and the blend that can form of higher molecular weight with the medium molecule weight polymers and the low-molecular-weight water-soluble plasticizer of its formation hydrogen bond, in the presence of suitable quantity of water, water-absorbent and resilient characteristic with hydrogel also have pressure-sensitive adhesive performance preferably.
Background technology
The pressure sensitive adhesive that field of medicaments is used is pressure sensitive adhesive (PSA) polysiloxane (as: blend of polydimethylsiloxane, poly-diphenyl siloxane and siloxanes) normally of transdermal administration system (TDDs) especially, the multipolymer of polyisobutene (PIB), polyacrylic ester, vinylformic acid and acrylate (as the multipolymer of vinylformic acid and ethyl acrylate or Isooctyl acrylate monomer), natural rubber and chloroprene rubber (polymeric 2-chlorobutadiene) etc.These all pressure sensitive adhesives all are hydrophobic polymers, and their common drawback is at wet environment or contains viscosity decline when adhering on the water surface, and is not suitable for the Transdermal absorption drug delivery system of hydrophilic medicament.Therefore, it is very necessary to have an exploitation of pressure sensitive adhesive of better bioadhesion performance.
" bioadhesion " is exactly the adhesion on the biological tissue of high-moisture such as mucosal tissue, skin, and the pressure sensitive adhesive with bioadhesive can show good viscosity when adhering to the higher matrix of water content.Water does not influence the cohesive strength of pressure sensitive adhesive, and pressure sensitive adhesive is played the plastifying effect, therefore, adopts hydrophilic polymer to improve hydrophobic pressure sensitive adhesive and has obtained exploitation by the pressure sensitive adhesive of hydrophilic polymer preparation.For example: lightly crosslinked polyacrylic acid that EP0371421 develops and polymethyl acrylic acid pressure sensitive adhesive; US4231369 carries out hydrophilization with Mierocrystalline cellulose and derivative thereof to polyisobutene; US5643187 carries out hydrophilization etc. with polyvinyl alcohol, collagen, gelatin to polyisobutene.But these hydrophilicity-imparting treatment cause the very big decline of cohesive strength owing to hydrophilic, hydrophobic phase consistency difference.
Adopt hydrophilic polymer blend, method such as crosslinked, preparation hydrophilic gel type pressure sensitive adhesive has prepared hydrophilic cellulose derivative (40-95%) and polyoxyethylene glycol (PEG) blend pressure sensitive adhesive as US 4713243; US5700478 is a kind of water-soluble pressure-sensitive mucous membrane glue, is to be made by 95-40%PVP, 0-50% hydroxypropylcellulose (HPC) and the blend of 11-60% glycerine.German Patent (DE4219368) then is the compound system of polyacrylic acid and polyvinyl alcohol (PAA-PVA), and is to form hydrogen bond between the monomeric unit of the polypropylene glycol of 425g/mol and polymer chain by hydroxyl simple plasticizer such as PEG-200, glycerine, molecular weight.
Patent WO0204570 has reported a kind of simpler, the preparation method of the hydrophilic pressure sensitive adhesive of better performances, be to adopt higher hydrophilic polymers of a kind of second-order transition temperature (Tg) and the softening agent blend of a kind of low Tg of having, have between softening agent and hydrophilic polymer preferably between consistency and the two can covalent linkage or non covalent bond crosslinked, lay special stress on the crosslinked composition of hydrogen bond between hydrophilic polymer and softening agent, preferred Polyvinylpyrolidone (PVP) (PVP, molecular weight 100000~2000000) with the co-mixing system of polyoxyethylene glycol (PEG, molecular weight 300~600).
Ideal bioadhesion pressure sensitive adhesive should just can be very fast under very light pressure effect stick on specified skin or the mucous membrane, and have long skin adherence, perviousness and with physics, the chemical compatibility of medicine, permeate promotor or other additive, and should nonirritant, do not cause acne and allergy.Simultaneously, pressure sensitive adhesive also will be kept enough adhesion times and avoid slippage, and can be with comparalive ease takes off and leave no trace from skin; Being exposed to moist environment and high humidity bounding force does not weaken; Can protect wound or can fixed electorde or Other Instruments; Should have also that anti-skin moves and can from binder matrix, transfer to performance on the skin to medicine.Purpose of the present invention is exactly a kind of hydrophilic pressure sensitive adhesive with above-mentioned premium properties of exploitation, especially is applicable to the pressure sensitive adhesive of Chinese herbs paste, is used for drug transdermal treatment system.
Summary of the invention
The major objective of this invention is promptly to provide a kind of preparation hydrophilic pressure sensitive adhesive and preparation method thereof in order to satisfy bioadhesion with the requirement of pressure sensitive adhesive, is used for transdermal administration system, iontophoresis system, wound treatment, bio-pharmaceutical electrode and other needs the equipment and the system of pressure sensitive adhesive.It two provides a kind of hydrophilic pressure sensitive adhesive with optimum adhesion force intensity, force of cohesion intensity and hydrophilic ability.It three has provided a kind of treatment system that can be used for part or percutaneous dosing formulation, includes the hydrophilic pressure sensitive adhesive of preparing in this invention in the system.
The present invention is realized by following technical proposals.
A kind of hydrophilic multicomponent mixture pressure sensitive adhesive, it is characterized in that this pressure sensitive adhesive comprises A at least, B, four kinds of component: component A of C and water are that a class is hydrophilic, distributing on the molecular chain and can form the group of hydrogen bond, molecular weight is one or more mixture of polymers of 100,000~2,000,000, A accounts for A, B, 30~70wt% of C total amount is selected from the homopolymer and the multipolymer of N-vinyl pyrrolidone and alkyl-substituted derivatives thereof, polyacrylic acid, polyacrylamide, polyamino acid, polymethyl acrylic acid, polyvinyl alcohol, the poly N-ethylene hexanolactam, Poly(Hydroxyethyl Methacrylate), polyvinylamine, poly-alkyl diamine; B component is that the molecular weight of a class hydroxyl, amino or carboxy blocking is 300~100000 polymkeric substance, B accounts for 10~40wt% of A, B, C total amount, it can be hydrophilic polymer, can be hydrophobic polymer also, be selected from end group and be in carboxyl, hydroxyl or amino polyethers, polyester, polymeric amide, urethane, the polyureas polymkeric substance one or more; Component C be under the water miscible room temperature of a class for liquid molecular weight is short chain polyvalent alcohol below 300 and 300 or amine and composition thereof, C accounts for 10~50wt% of A, B, C total amount; Water accounts for 5~50wt% of pressure sensitive adhesive.
Above-mentioned hydrophilic multicomponent mixture pressure sensitive adhesive, the molecular weight that it is characterized in that the A component is 200,000~500,000, and polymkeric substance is multipolymer, poly N-ethylene hexanolactam and their mixture of poly N-vinyl pyrrolidone, N-vinyl pyrrolidone and vinyl acetate between to for plastic; The B component is polypropylene oxide glycol, polyoxyethylene glycol, propylene oxide and ethylene oxide copolymer glycol, polycaprolactone glycol, poly(lactic acid), polyamino acid, polyvinyl alcohol, polyacrylic acid, polyhydroxybutyrate, poly N-ethylene hexanolactam, Poly(Hydroxyethyl Methacrylate), polyvinylamine; The C component is glycerine, ethylene glycol, butyleneglycol, polyoxyethylene glycol.
The application of above-mentioned hydrophilic multicomponent mixture pressure sensitive adhesive, it is characterized in that this pressure sensitive adhesive can use separately, or be used for pressure-sensitive adhesion with medicine, tensio-active agent, ionogen, permeate promotor, various inorganic and combination of organic additives and use, and be used for drug transdermal absorbable preparation system.
In the above-mentioned multicomponent mixture pressure sensitive adhesive, B, the C group on two end group positions and A macromolecular chain respectively form hydrogen bond, form long and short bridge formation chain between the macromolecular chain of A respectively, the supramolecule network structure that causes A macromole interchain hydrogen bond to connect; Flexible B, C chain have increased polymer A molecule interchain distance effectively, and bigger deformability of cross-linked network and liquid flowability are provided, and simultaneously, cross-linked network can provide the anti-flowability of good force of cohesion intensity and rubbery state.As shown in Figure 1; The length of the bridge formation chain by two kinds of different lengthss and ratio change, can regulate network density, the snappiness of cross-linked network, thereby more easily satisfy the different application occasion performance demands such as the pressure sensitive adhesive of pressure sensitive adhesive, elasticity, intensity, water-absorbent, drug release.The invention has the advantages that the limitation that has overcome the single cross-linked network structure of common commixed type pressure sensitive adhesive, as blend between a kind of PVP of patent WO0204570 and a kind of PEG, the bridge formation chain that the network structure that forms has equal length, difficulty is carried out the adjusting and the control of pressure sensitive adhesive characteristic.
On the other hand, if two end groups of C can also form hydrogen bond or electrostatic interaction with the group on the molecular chain of B, cause B molecule interchain cross-linked network, then A, B, C co-mixing system form and have the crosslinked network structure of dual non covalent bond of IPN, as shown in Figure 2.The dual non covalent bond cross-linked network of this IPN more helps promoting the intensity and the toughness of co-mixing system, overcome the crosslinked low shortcoming of blend pressure sensitive adhesive intensity of wetting ability non covalent bond, instruments such as counter electrode have stable fixed action and to the long-time adhesive attraction of skin, can also improve the charge capacity of medicine and the control performance that medicine discharges through skin.
In addition, B component can be a hydrophilic polymer, also can be hydrophobic polymer.Hydrophilic component B can increase the water-absorbent of cross-linked network, the transdermal penetration that helps forming the bank of hydrophilic medicament, ionic drug and promote medicine.Hydrophobic components B then can form hydrophobic microcell in the blend pressure sensitive adhesive, it is amphipathic that the blend pressure sensitive adhesive is had, hydrophobic drug also had bigger affinity, thereby make pressure sensitive adhesive all have storage power preferably, be particularly useful for the preparation of multicomponent pharmaceutical and herbal mixture Transdermal absorption drug delivery system hydrophilic, hydrophobic property medicine.
The preparation method of above-mentioned pressure sensitive adhesive is very simple, only needs in a container, mix A, B, C component and a certain amount of water, and coating then, 60~80 ℃ of dry down adjusting water content are 5~50% to get final product.
Above-mentioned pressure sensitive adhesive is applicable to that bioadhesion and other need make the occasion that pressure-sensitive paster uses, be used for bandage, the dressing of wound or scald is as facial mask, conductive adhesive material, makeup, topical pharmaceutical formulation and other pressure-sensitive product are as utensil, product surface attaching etc.
The sheet sticking tablet that above-mentioned hydrophilic multicomponent mixture pressure sensitive adhesive forms comprises: (1) described hydrophilic multicomponent mixture pressure sensitive adhesive; (2) binder component comprises medicine, glycerine, water, tensio-active agent, ionogen, permeate promotor, various inorganic or organic additive.
The transdermal administration system that forms comprises:
A) drug-reservoir comprises the hydrophilic multicomponent mixture pressure sensitive adhesive that (1) is above-mentioned; (2) medicine of significant quantity; Or (3) binder component, as permeate promotor etc.
B) lamellated back lining materials is in the drug-reservoir outside.
C) protective membrane mainly in storage, works before promptly using.
Its Chinese traditional medicine can be anticancer, relieving asthma, multiple types of drugs such as dispelling the wind and dampness pathogens, pain relieving, anesthesia, stimulant, can be liquid, solid, semisolid or Chinese medical concrete, plant milk extract etc.Multiple permeate promotor: alcohol, acid, polyvalent alcohol, polyprotonic acid etc.; Back lining materials is normally: polyester, polyethylene, polypropylene, urethane, polyetheramine, non-woven fabrics etc., thickness is at 15~250 microns.Preferably gas-pervious, can see through steam.The requirement of protective membrane is easily to take off, and does not interact between medicine.In addition, can also in transdermal absorption formulation, be added with extra play, as controlled release layer (optionally discharge) etc.
When being processed into the pressure sensitive adhesive product with present component, through simply extrude, coating process can be achieved, and avoided organic solvent and traditional time-consuming mixing and casting process.And can be according to the intensity of wetting ability, bounding force and the force of cohesion of hygroscopic property, hope and the composition that useful for drug delivery kinetics is adjusted tackiness agent.
Description of drawings
The hydrogen bond cross-linked structure synoptic diagram of Fig. 1 long-chain hydrophilic polymer A and intermediate molecular weight B component, the intermolecular formation of short chain softening agent C.
The IPN hydrogen bond cross-linked structure synoptic diagram of Fig. 2 long-chain hydrophilic polymer A and intermediate molecular weight B component, the intermolecular formation of short chain softening agent C.
The pressure sensitive adhesive of Fig. 3 load different pharmaceutical (PVP-PEG series) patch TDDs1, TDDs2, TDDs3 are through the medicine-releasing performance of mouse skin.
The pressure sensitive adhesive of Fig. 4 load different pharmaceutical (PVP-PDLLA series) patch TDDs4, TDDs5, TDDs6 are through the medicine-releasing performance of mouse skin.
Embodiment
The preparation method of embodiment 1~22 pressure sensitive adhesive adds A, B, C component and a certain amount of water in a container, stirring makes and mixes, can suitably heat (below 130 ℃) and promote mix, mix the back coating, be dried to water content under 60~80 ℃ and be 5~50% and get final product.Water-insoluble pressed powder sample adopts water-soluble solvent wiring solution-forming remix earlier.The composition of embodiment 1~22 pressure sensitive adhesive sees Table 1, and performance sees Table 2.
Table 1 embodiment 1~22 wetting ability blend pressure sensitive adhesive is formed
Embodiment | Component A (molecular weight) | B component (molecular weight) | Component C (molecular weight) | Water | Other |
1 | PVP (300,000) 70g | PHB (100,000) 10g | Glycerine 20g | 20g | Gelatin 2g |
2 | PVP (1,000,000) 40g | PHB (20,000) 20g | Polyoxyethylene glycol (200) 40g | 5.4g |
3 | PVP (2,000,000) 55g | PEG(300) 30g | Butyleneglycol 15g | 45g | |
4 | PVP (1,500,000) 47g | PEG(600) 13g | Glycerine 40g | 25g | |
5 | PVP (1,000,000) 50g | PEG91000) 20g | Glycerine 30g | 30g | |
6 | PVP (400,000) 52g | PEG(2000) 25g | Glycerine 23g | 42g | |
7 | PVP (1,000,000) 63g | PCL(1000) 12g | PEG(200) 25g | 40g | |
8 | PVP (1,000,000) 50g | PCL(2000) 22g | PEG(200) 28g | 30g | Silicone oil 1.5g |
9 | PVP-PVE (200,000) 58g | PCL (20,000) 18g | Glycerine 24g | 40g | |
10 | PVP (1,000,000) 65g | PDLLA(2000) 15g | PEG(200) 20g | 100g | |
11 | PVC (1,200,000) 50g | PDLLA(800) 28g | Ethylene glycol 22g | 56g | |
12 | PVP (1,000,000) 43g | PDLLA (10,000) 25g | PEG(200) 32g | 50g | |
13 | PVC (1,000,000) 50g | PPO(1000) 23g | Glycerine 27g | 20g | |
14 | PVC (1,000,000) 60g | PPO(3000) 30g | PEG(300) 10g | 35g | |
15 | PVC (500,000) 70g | PPO(6000) 13g | Glycerine 17g | 70g | |
16 | PVC (800,000) 50g | PEO-PPO (10,000) 14g | PEG(200) 36g | 41g | |
17 | Poly aspartic acid (100,000) 40g | PVA (60,000) 20g | Glycerine 40g | 8g | |
18 | PVA (200,000) 45g | PCL (50,000) 30g | PEG(300) 25g | 26g | |
19 | PAM (800,000) 30g | PVA(5000) 30g | PEG(200) 40g | 15g | |
20 | PMA (400,000) 42g | PEI(1000) 31g | Glycerine 27g | 23g | |
21 | PHEMA (400,000) 37g | PDDLA(800) 34g | Butyleneglycol 29g | 33g | |
22 | PAA (200,000) 35g | PEI(1000) 15g | Glycerine 50g | 10g |
Annotate: PVP is a poly N-vinyl pyrrolidone; PVC is the poly N-ethylene hexanolactam; PDLLA is poly-D, L lactic acid; PCL is a polycaprolactone glycol; PEG is a polyoxyethylene glycol; PAA is a polyacrylic acid; PEI is a polymine; PPO is a polypropylene oxide glycol; PEO-PPO is for going back oxidative ethane and going back the Ethylene Oxide multipolymer; PMA is a polymethyl acrylic acid; PHEMA is a Poly(Hydroxyethyl Methacrylate); PAM is a polyacrylamide; PHB is a polyhydroxybutyrate.
Example 23~25:
Take by weighing commixed type pressure sensitive adhesive (is example with the example 4 described pressure sensitive adhesives) 10g in the example, add 5% salicylic ethanol (75% ethanol prepare, 25% deionized water) solution 10g, mix, ethanol is removed in evaporation, and the cloth of filming on non-woven fabrics is then made Whitfield's ointment transdermal patch (TDDs1); Prepare the percutaneous absorption patch of metronidazole, diclofenac with same method, be respectively TDDs2, TDDs3
Example 26~28:
Take by weighing commixed type pressure sensitive adhesive (is example with the example 10 described pressure sensitive adhesives) 10g in the example, add 5% salicylic ethanol (75% ethanol prepare, 25% deionized water) solution 10g, mix, ethanol is removed in evaporation, and the cloth of filming on non-woven fabrics is then made Whitfield's ointment transdermal patch (TDDs4); Prepare the percutaneous absorption patch of metronidazole, diclofenac with same method, be respectively TDDs5, TDDs6.
Example 29~31
Take by weighing commixed type pressure sensitive adhesive (is example with the example 10 described pressure sensitive adhesives) 10g in the example, respectively with 3g, 5g, 6.2g Chinese medical concrete (to breathe heavily cream be example to cough), mix, mixing the back films on non-woven fabrics, make to cough and breathe heavily the cream transdermal patch, be respectively TDDs7, TDDs8, TDDs9.
The adhesive property such as the table 2 of pressure sensitive adhesive and transdermal patch in the foregoing description.
23 ℃ of following table one pressure sensitive adhesive characteristics of table 2
Pressure sensitive adhesive or patch | Spin (#) | Stripping strength (N) | Hold viscous force (h) | Moisture transmission (g/m 2/24h) |
1 | 13 | 14.36 | 17 | 635 |
2 | 13 | 11.54 | 15 | 576 |
3 | 15 | 13.22 | 18 | 521 |
4 | 12 | 10.85 | 13 | 489 |
5 | 12 | 9.68 | 14 | 658 |
6 | 14 | 11.20 | 14 | 502 |
7 | 11 | 12.63 | 15 | 436 |
8 | 12 | 9.88 | 13 | 410 |
9 | 12 | 10.17 | 14 | 425 |
10 | 13 | 11.56 | 15 | 476 |
11 | 14 | 12.53 | 15 | 543 |
12 | 13 | 13.17 | 16 | 507 |
13 | 12 | 10.87 | 13 | 495 |
14 | 11 | 11.40 | 15 | 420 |
15 | 13 | 12.10 | 14 | 415 |
16 | 10 | 10.5 | 13 | 406 |
17 | 11 | 9.2 | 12 | 532 |
18 | 15 | 10.87 | 14 | 512 |
19 | 10 | 11.20 | 13 | 465 |
20 | 12 | 13.25 | 15 | 541 |
21 | 14 | 11.90 | 14 | 582 |
22 | 11 | 12.80 | 13 | 466 |
23(TDDs1) | 12 | 10.98 | 12 | 641 |
24(TDDs2) | 14 | 11.30 | 13 | 622 |
25(TDDs3) | 14 | 11.12 | 12 | 631 |
26(TDDs4) | 14 | 11.06 | 14 | 481 |
27(TDDs5) | 15 | 11.21 | 14 | 490 |
28(TDDs6) | 14 | 10.98 | 15 | 486 |
29(TDDs7) | 15 | 10.54 | 14 | 501 |
30(TDDs8) | 15 | 10.24 | 14 | 496 |
31(TDDs9) | 15 | 10.15 | 13 | 488 |
Annotate: 1. tack: test according to GB4852-84; Hold viscous force: test according to GB4851-84; 180 ° of stripping strengths: test according to GB2792-81.
2. gas permeability test adopts following scheme:
(1) get the known watch-glass of a floorage (s), inject the distilled water of its volume 2/3 therein, (W weighs
1).
(2) get the enough big even coated pressure sensitive adhesive sample of a surface-area, its glue is lived in to state the watch-glass that is filled with water towards water-lute, place 23 ℃, in relative humidity 65% environment, placed 24 hours.
(3) watch-glass (W that seals with pressure sensitive adhesive in the weighing (2)
2).
(4) calculate moisture transmission
Claims (3)
1. hydrophilic multicomponent mixture pressure sensitive adhesive, it is characterized in that this pressure sensitive adhesive comprises A at least, B, four kinds of component: component A of C and water are that a class is hydrophilic, distributing on the molecular chain and can form the group of hydrogen bond, molecular weight is one or more mixture of polymers of 100,000~2,000,000, A accounts for A, B, 30~70wt% of C total amount is selected from the homopolymer and the multipolymer of N-vinyl pyrrolidone and alkyl-substituted derivatives thereof, polyacrylic acid, polyacrylamide, polyamino acid, polymethyl acrylic acid, polyvinyl alcohol, poly-N-7 alkene hexanolactam, Poly(Hydroxyethyl Methacrylate), polyvinylamine, poly-alkyl diamine; B component is that the molecular weight of a class hydroxyl, amino or carboxy blocking is 300~100000 polymkeric substance, B accounts for 10~40wt% of A, B, C total amount, it can be hydrophilic polymer, can be hydrophobic polymer also, be selected from end group and be in carboxyl, hydroxyl or amino polyethers, polyester, polymeric amide, urethane, the polyureas polymkeric substance one or more; Component C be under the water miscible room temperature of a class for liquid molecular weight is short chain polyvalent alcohol below 300 and 300 or amine and composition thereof, C accounts for 10~50wt% of A, B, C total amount; Water accounts for 5~50wt% of pressure sensitive adhesive.
2. by the described a kind of hydrophilic multicomponent mixture pressure sensitive adhesive of claim 1, the molecular weight that it is characterized in that the A component is 200,000~500,000, and polymkeric substance is multipolymer, poly N-ethylene hexanolactam and their mixture of poly N-vinyl pyrrolidone, N-vinyl pyrrolidone and vinyl acetate between to for plastic; The B component is polypropylene oxide glycol, polyoxyethylene glycol, propylene oxide and ethylene oxide copolymer glycol, polycaprolactone glycol, poly(lactic acid), polyamino acid, polyvinyl alcohol, polyacrylic acid, polyhydroxybutyrate, poly N-ethylene hexanolactam, Poly(Hydroxyethyl Methacrylate), polyvinylamine; The C component is glycerine, ethylene glycol, butyleneglycol, polyoxyethylene glycol.
3. application by the described hydrophilic multicomponent mixture pressure sensitive adhesive of claim 1, it is characterized in that this pressure sensitive adhesive can use separately, or be used for pressure-sensitive adhesion with medicine, tensio-active agent, ionogen, permeate promotor, various inorganic and combination of organic additives and use, and be used for drug transdermal absorbable preparation system.
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DE102008031183A1 (en) * | 2008-07-03 | 2010-01-07 | Paul Hartmann Ag | wound dressing |
CN101760158B (en) * | 2008-12-24 | 2012-02-01 | 四川汇利实业有限公司 | Alcohol-water type environmental-protection safety composite adhesive preparation method |
CN103436164B (en) * | 2013-09-03 | 2015-12-02 | 丽水学院 | For mixing solutions and the treatment process of the process of ABS engineering plastic surface |
CN105647160B (en) * | 2016-01-06 | 2018-08-24 | 姜琪 | A kind of preparation method of the resin containing water-soluble plasticizer and polyurethane |
CN110755711A (en) * | 2019-10-31 | 2020-02-07 | 慧生医学科技(徐州)有限公司 | Photolysis-adhesion infusion patch |
CN112704764B (en) * | 2020-12-28 | 2022-07-08 | 杭州高斯博医疗用品有限公司 | Hydrophilic self-adhesive suitable for cold compress self-adhesive compression bandage, preparation method and application |
CN114196328B (en) * | 2021-11-23 | 2024-05-10 | 日铭电脑配件(上海)有限公司 | Removable adhesive, removable adhesive tape, preparation method and application of removable adhesive |
CN114249863B (en) * | 2022-01-20 | 2023-01-24 | 西安交通大学 | Hydrogen bond enhanced photo-curing hard tissue adhesive and preparation method and use method thereof |
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