CN1249067C - 银杏内酯a、b、c提取工艺及其制剂 - Google Patents
银杏内酯a、b、c提取工艺及其制剂 Download PDFInfo
- Publication number
- CN1249067C CN1249067C CN03152921.6A CN03152921A CN1249067C CN 1249067 C CN1249067 C CN 1249067C CN 03152921 A CN03152921 A CN 03152921A CN 1249067 C CN1249067 C CN 1249067C
- Authority
- CN
- China
- Prior art keywords
- bilobalide
- ginkgolide
- ethanol
- ginkalide
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- MOLPUWBMSBJXER-YDGSQGCISA-N bilobalide Chemical compound O([C@H]1OC2=O)C(=O)[C@H](O)[C@@]11[C@@](C(C)(C)C)(O)C[C@H]3[C@@]21CC(=O)O3 MOLPUWBMSBJXER-YDGSQGCISA-N 0.000 title claims description 103
- 238000000034 method Methods 0.000 title description 14
- 229930063422 Bilobalide A Natural products 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 67
- 239000004952 Polyamide Substances 0.000 claims abstract description 20
- 229920002647 polyamide Polymers 0.000 claims abstract description 20
- 239000006187 pill Substances 0.000 claims abstract description 18
- 235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 235000011201 Ginkgo Nutrition 0.000 claims abstract description 13
- 238000000605 extraction Methods 0.000 claims abstract description 13
- 238000005516 engineering process Methods 0.000 claims abstract description 12
- 239000000284 extract Substances 0.000 claims abstract description 11
- 239000008187 granular material Substances 0.000 claims abstract description 11
- 239000011347 resin Substances 0.000 claims abstract description 8
- 229920005989 resin Polymers 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims abstract description 5
- 244000194101 Ginkgo biloba Species 0.000 claims abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- SQOJOAFXDQDRGF-WJHVHIKBSA-N ginkgolide B Natural products O=C1[C@@H](C)[C@@]2(O)[C@@H]([C@H](O)[C@]34[C@@H]5OC(=O)[C@]23O[C@H]2OC(=O)[C@H](O)[C@@]42[C@H](C(C)(C)C)C5)O1 SQOJOAFXDQDRGF-WJHVHIKBSA-N 0.000 claims description 31
- FPUXKXIZEIDQKW-MFJLLLFKSA-N ginkgolide A Natural products O=C1[C@H](C)[C@@]2(O)[C@@H](O1)C[C@]13[C@@H]4OC(=O)[C@]21O[C@@H]1OC(=O)[C@H](O)[C@]31[C@@H](C(C)(C)C)C4 FPUXKXIZEIDQKW-MFJLLLFKSA-N 0.000 claims description 29
- FPUXKXIZEIDQKW-VKMVSBOZSA-N ginkgolide-a Chemical compound O[C@H]([C@]12[C@H](C(C)(C)C)C[C@H]3OC4=O)C(=O)O[C@H]2O[C@]24[C@@]13C[C@@H]1OC(=O)[C@@H](C)[C@]21O FPUXKXIZEIDQKW-VKMVSBOZSA-N 0.000 claims description 29
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 20
- 241000218628 Ginkgo Species 0.000 claims description 12
- 238000010828 elution Methods 0.000 claims description 11
- 239000008118 PEG 6000 Substances 0.000 claims description 10
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 10
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 10
- 229920001353 Dextrin Polymers 0.000 claims description 9
- 239000004375 Dextrin Substances 0.000 claims description 9
- 235000019425 dextrin Nutrition 0.000 claims description 9
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 claims description 9
- 238000001953 recrystallisation Methods 0.000 claims description 9
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 229930006000 Sucrose Natural products 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 5
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 5
- 108010011485 Aspartame Proteins 0.000 claims description 4
- 229920000881 Modified starch Polymers 0.000 claims description 4
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 4
- 229960003438 aspartame Drugs 0.000 claims description 4
- 235000010357 aspartame Nutrition 0.000 claims description 4
- 239000000605 aspartame Substances 0.000 claims description 4
- 238000007670 refining Methods 0.000 claims description 4
- 238000002425 crystallisation Methods 0.000 claims description 3
- 230000008025 crystallization Effects 0.000 claims description 3
- 230000001186 cumulative effect Effects 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 2
- 238000000926 separation method Methods 0.000 claims description 2
- 238000010521 absorption reaction Methods 0.000 abstract description 2
- 239000000047 product Substances 0.000 abstract description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 239000013078 crystal Substances 0.000 abstract 2
- 239000012043 crude product Substances 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 150000002596 lactones Chemical class 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 239000003507 refrigerant Substances 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 230000006837 decompression Effects 0.000 description 2
- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- SQOJOAFXDQDRGF-MMQTXUMRSA-N ginkgolide-b Chemical compound O[C@H]([C@]12[C@H](C(C)(C)C)C[C@H]3OC4=O)C(=O)O[C@H]2O[C@]24[C@@]13[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]21O SQOJOAFXDQDRGF-MMQTXUMRSA-N 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000010118 platelet activation Effects 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- RHAXKFFKGZJUOE-UHFFFAOYSA-N 7-acetyl-6-ethyl-3,5,8-trihydroxy-9,10-dioxoanthracene-1,2-dicarboxylic acid Chemical compound O=C1C2=CC(O)=C(C(O)=O)C(C(O)=O)=C2C(=O)C2=C1C(O)=C(CC)C(C(C)=O)=C2O RHAXKFFKGZJUOE-UHFFFAOYSA-N 0.000 description 1
- 208000024827 Alzheimer disease Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- AMOGMTLMADGEOQ-FNZROXQESA-N Ginkgolide C Chemical compound O([C@H]1O2)C(=O)[C@H](O)C31[C@]14[C@@H](O)[C@@H]5OC(=O)[C@@H](C)[C@]5(O)[C@@]12C(=O)O[C@@H]4[C@@H](O)[C@H]3C(C)(C)C AMOGMTLMADGEOQ-FNZROXQESA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229940123251 Platelet activating factor antagonist Drugs 0.000 description 1
- 206010036631 Presenile dementia Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- -1 contains A Chemical compound 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- AMOGMTLMADGEOQ-DPFZUGDXSA-N ginkgolide C Natural products O=C1[C@@H](C)[C@]2(O)[C@H]([C@H](O)[C@@]34[C@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]63[C@H](O)C(=O)O[C@H]6O[C@@]24C(=O)O5)O1 AMOGMTLMADGEOQ-DPFZUGDXSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000003848 thrombocyte activating factor antagonist Substances 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 235000012431 wafers Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN03152921.6A CN1249067C (zh) | 2003-08-30 | 2003-08-30 | 银杏内酯a、b、c提取工艺及其制剂 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN03152921.6A CN1249067C (zh) | 2003-08-30 | 2003-08-30 | 银杏内酯a、b、c提取工艺及其制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1491950A CN1491950A (zh) | 2004-04-28 |
CN1249067C true CN1249067C (zh) | 2006-04-05 |
Family
ID=34240729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN03152921.6A Expired - Lifetime CN1249067C (zh) | 2003-08-30 | 2003-08-30 | 银杏内酯a、b、c提取工艺及其制剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1249067C (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8495884B2 (en) | 2001-02-09 | 2013-07-30 | Bsst, Llc | Thermoelectric power generating systems utilizing segmented thermoelectric elements |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1315481C (zh) * | 2004-07-16 | 2007-05-16 | 北京国仁堂医药科技发展有限公司 | 一种银杏叶提取物及其提取方法 |
CN1977868B (zh) * | 2005-12-05 | 2010-12-29 | 浙江海正药业股份有限公司 | 银杏叶总内酯提取物及其制备方法、药物组合物和用途 |
CN101422456B (zh) * | 2007-11-02 | 2011-05-04 | 江苏康缘药业股份有限公司 | 一种药物组合物滴丸的制备方法和质量检测方法 |
CN102464666B (zh) * | 2010-11-09 | 2015-04-08 | 上海医药工业研究院 | 一种银杏内酯c的制备方法 |
CN102659808B (zh) | 2012-04-23 | 2014-10-29 | 成都百裕科技制药有限公司 | 一种银杏内酯的提取分离方法 |
CN103588785B (zh) * | 2013-11-28 | 2016-04-20 | 上海信谊百路达药业有限公司 | 一种银杏内酯a与银杏内酯b的精制方法 |
CN104356141B (zh) * | 2014-11-27 | 2017-12-01 | 中国药科大学 | 一种银杏内酯l的制备方法 |
-
2003
- 2003-08-30 CN CN03152921.6A patent/CN1249067C/zh not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8495884B2 (en) | 2001-02-09 | 2013-07-30 | Bsst, Llc | Thermoelectric power generating systems utilizing segmented thermoelectric elements |
Also Published As
Publication number | Publication date |
---|---|
CN1491950A (zh) | 2004-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2430017B1 (en) | A method for preparing AMORPHOUS SILIBININ | |
CN1249067C (zh) | 银杏内酯a、b、c提取工艺及其制剂 | |
CN102432582A (zh) | 一种原花青素的制备方法 | |
CN101054377A (zh) | 夏天无总生物碱提取物、其制备方法、含该总生物碱提取物的药物组合物及其应用 | |
CN111317750A (zh) | 番荔枝种子总内酯在制备防治糖尿病的药物中的应用 | |
CN1899297A (zh) | 密脉鹅掌柴提取物及在制药中的应用 | |
JP2014503489A (ja) | ジヒドロクエルセチンを製造する方法 | |
CN1083267C (zh) | 山楂的提取产物、药用组合物及其用途 | |
CN1803787A (zh) | 贯叶金丝桃总黄酮提取物、其制备及应用 | |
CN102488721B (zh) | 一种银杏叶提取物的制备方法及其制剂 | |
CN1965898A (zh) | 一种复方丹参胶囊及其制备方法 | |
CN103610708B (zh) | 一种银杏根皮中低酸高纯度萜内酯提取物的制备工艺 | |
CN1321651C (zh) | 复方丹参方两类有效部位口腔喷雾剂及制备工艺 | |
CN1775247A (zh) | 首乌地黄制剂及新的制备方法 | |
CN1824016A (zh) | 复方首乌地黄制剂及新的制备方法 | |
CN1602920A (zh) | 高质量的银杏叶提取物及制作工艺 | |
CN1824113A (zh) | 产后益母制剂及新的制备方法 | |
CN1751706A (zh) | 一种丹参药材的提取方法 | |
US20220133689A1 (en) | Tongkat ali extract production processes and uses thereof | |
CN1895495A (zh) | 一种治疗胃病的猴头健胃灵软胶囊 | |
CN101244106B (zh) | 亚贡抗糖尿病提取物及制备方法 | |
CN101040883A (zh) | 一种穿心莲根提取物及其制备方法和应用 | |
CN1583735A (zh) | 一种富集藁本内酯的工艺及其制剂 | |
CN1166675C (zh) | 生产高活性银杏叶提取物的萃取剂及其提取与分析方法 | |
CN1543968A (zh) | 用桑白皮提取物制备的药物制剂 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shenzhen Southern Yingxin Pharmaceutical Co.,Ltd. Assignor: Cao Mingcheng Contract fulfillment period: 2008.10.13 to 2022.10.12 Contract record no.: 2009440000738 Denomination of invention: Extracting process for bilobalide A, B, C and its preparation Granted publication date: 20060405 License type: Exclusive license Record date: 20090721 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.10.13 TO 2022.10.12; CHANGE OF CONTRACT Name of requester: SHENZHEN NANFANG YINGXIN PHARMACY CO., LTD. Effective date: 20090721 |
|
ASS | Succession or assignment of patent right |
Owner name: GUANGDONG JINFANG PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: CAO MINGCHENG Effective date: 20101026 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 230001 NO.296, TUNXI ROAD, HEFEI CITY, ANHUI PROVINCE TO: 510010 13A01, BAIYUN BUILDING, NO.111-113, BAIYUN ROAD, YUEXIU DISTRICT, GUANGZHOU CITY, GUANGDONG PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20101026 Address after: 510010 Baiyun tower, 111-113 Baiyun Road, Guangzhou, Guangdong, Yuexiu District 13A01 Patentee after: Guangdong JinFang Pharmaceutical Co.,Ltd. Address before: 230001 No. 296, Tunxi Road, Hefei, Anhui Patentee before: Cao Mingcheng |
|
TR01 | Transfer of patent right |
Effective date of registration: 20190621 Address after: 611130 Chengdu Wenjiang District, Chengdu, Sichuan Province, Cross-Strait Science and Technology Industry Development Park Patentee after: CHENGDU BAIYU PHARMACEUTICAL Co.,Ltd. Address before: 510010 Baiyun Building 13A01, 111-113 Baiyun Road, Yuexiu District, Guangzhou City, Guangdong Province Patentee before: Guangdong JinFang Pharmaceutical Co.,Ltd. |
|
TR01 | Transfer of patent right | ||
CX01 | Expiry of patent term |
Granted publication date: 20060405 |
|
CX01 | Expiry of patent term |