CN1244339C - 一种治疗和预防脂肪肝的中药及其制备工艺 - Google Patents
一种治疗和预防脂肪肝的中药及其制备工艺 Download PDFInfo
- Publication number
- CN1244339C CN1244339C CNB2004100146866A CN200410014686A CN1244339C CN 1244339 C CN1244339 C CN 1244339C CN B2004100146866 A CNB2004100146866 A CN B2004100146866A CN 200410014686 A CN200410014686 A CN 200410014686A CN 1244339 C CN1244339 C CN 1244339C
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- carapace
- fatty liver
- radix
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003814 drug Substances 0.000 title claims abstract description 72
- 208000004930 Fatty Liver Diseases 0.000 title claims abstract description 38
- 206010019708 Hepatic steatosis Diseases 0.000 title claims abstract description 38
- 208000010706 fatty liver disease Diseases 0.000 title claims abstract description 38
- 231100000240 steatosis hepatitis Toxicity 0.000 title claims abstract description 38
- 238000000034 method Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 62
- 229940079593 drug Drugs 0.000 claims abstract description 27
- 238000011282 treatment Methods 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 8
- 239000000284 extract Substances 0.000 claims abstract description 3
- 239000000843 powder Substances 0.000 claims description 21
- 238000005516 engineering process Methods 0.000 claims description 17
- 230000002265 prevention Effects 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 13
- 238000010992 reflux Methods 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 6
- 241000371997 Eriocheir sinensis Species 0.000 claims description 5
- 241001529553 Scoparia <angiosperm> Species 0.000 claims description 5
- 241001600153 Charybdis japonica Species 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 238000002347 injection Methods 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 4
- 239000006187 pill Substances 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 241000238040 Panulirus Species 0.000 claims description 3
- 241000927735 Penaeus Species 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims description 3
- 238000007710 freezing Methods 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000004321 preservation Methods 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 26
- 239000008280 blood Substances 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 20
- 201000010099 disease Diseases 0.000 abstract description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 8
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 238000011161 development Methods 0.000 abstract description 2
- 239000012535 impurity Substances 0.000 abstract description 2
- 150000002632 lipids Chemical class 0.000 abstract description 2
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 abstract 1
- 241000427159 Achyranthes Species 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 244000132619 red sage Species 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 description 39
- 241001465754 Metazoa Species 0.000 description 28
- 241000700159 Rattus Species 0.000 description 22
- 238000012360 testing method Methods 0.000 description 16
- 230000037396 body weight Effects 0.000 description 14
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 14
- 230000001737 promoting effect Effects 0.000 description 11
- 239000013641 positive control Substances 0.000 description 10
- 210000003734 kidney Anatomy 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 8
- 230000017531 blood circulation Effects 0.000 description 7
- 210000002784 stomach Anatomy 0.000 description 6
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 6
- 241000699670 Mus sp. Species 0.000 description 5
- 230000002496 gastric effect Effects 0.000 description 5
- 238000001802 infusion Methods 0.000 description 5
- 210000000056 organ Anatomy 0.000 description 5
- 108700022737 rat Fat1 Proteins 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 210000003608 fece Anatomy 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- 210000001541 thymus gland Anatomy 0.000 description 4
- 210000001519 tissue Anatomy 0.000 description 4
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 229920001661 Chitosan Polymers 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- GGLZPLKKBSSKCX-YFKPBYRVSA-N L-ethionine Chemical compound CCSCC[C@H](N)C(O)=O GGLZPLKKBSSKCX-YFKPBYRVSA-N 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 235000012000 cholesterol Nutrition 0.000 description 3
- 208000019425 cirrhosis of liver Diseases 0.000 description 3
- 239000003172 expectorant agent Substances 0.000 description 3
- 230000003419 expectorant effect Effects 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 238000003304 gavage Methods 0.000 description 3
- 239000012567 medical material Substances 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 208000031648 Body Weight Changes Diseases 0.000 description 2
- 241000721047 Danaus plexippus Species 0.000 description 2
- 206010019799 Hepatitis viral Diseases 0.000 description 2
- 208000035150 Hypercholesterolemia Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000004579 body weight change Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000004087 circulation Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000036425 denaturation Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 231100000283 hepatitis Toxicity 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 231100000682 maximum tolerated dose Toxicity 0.000 description 2
- 238000000386 microscopy Methods 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000008506 pathogenesis Effects 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- 230000002992 thymic effect Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 201000001862 viral hepatitis Diseases 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 1
- 235000003826 Artemisia Nutrition 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000921896 Charybdis <crab> Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 241000238557 Decapoda Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241001532056 Grapsidae Species 0.000 description 1
- 206010019663 Hepatic failure Diseases 0.000 description 1
- 208000031226 Hyperlipidaemia Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 241000238035 Palinuridae Species 0.000 description 1
- 241000238550 Penaeidae Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 201000007930 alcohol dependence Diseases 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 235000009052 artemisia Nutrition 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000035568 catharsis Effects 0.000 description 1
- 208000026106 cerebrovascular disease Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 201000005577 familial hyperlipidemia Diseases 0.000 description 1
- 230000037308 hair color Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 210000005229 liver cell Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 208000007903 liver failure Diseases 0.000 description 1
- 231100000835 liver failure Toxicity 0.000 description 1
- 241000238565 lobster Species 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 210000001113 umbilicus Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
Description
组别 | 给药量(g/kg) | 天数 | |||
0 | 5 | 10 | 15 | ||
模型组 | - | 202.5±17.7 | 194.4±21.9* | 221.3±17.5** | 220.6±21.3** |
空白对照组 | - | 202.5±17.3 | 217.5±16.5 | 238.1±16.7 | 253.1±21.0 |
本发明低剂量组 | 1.26 | 201.9±17.5 | 198.1±13.9* | 210.0±19.1** | 226.9±22.2* |
本发明中剂量组 | 2.52 | 204.4±17.8 | 200.6±14.7* | 220.0±17.1* | 230.6±24.8 |
本发明高剂量组 | 5.04 | 205.0±15.8 | 198.1±16.7* | 216.9±21.7* | 235.6±19.9 |
阳性对照组 | 1.00 | 210.0±16.3 | 198.1±17.9* | 215.0±20.2* | 232.5±24.3 |
组别 | 给药量(g/kg) | 动物数(只) | 肝脏 | 脾脏 | 胸腺 |
模型组 | - | 8 | 11.75±1.80 | 1.70±0.33 | 0.22±0.09 |
空白对照组 | - | 8 | 10.19±0.62* | 1.20±0.18** | 0.59±0.13*** |
本发明低剂量组 | 1.26 | 8 | 9.94±1.23* | 1.25±0.32* | 0.38±0.15* |
本发明中剂量组 | 2.52 | 8 | 9.98±1.34* | 1.16±0.30** | 0.46±0.21** |
本发明高剂量组 | 5.04 | 8 | 9.79±1.49* | 1.08±0.36** | 0.43±0.09*** |
阳性对照组 | 1.00 | 8 | 9.98±1.35* | 1.21±0.27** | 0.49±0.24** |
组别 | 给药量(g/kg) | 动物数(只) | T-ch(mmol/L) | TG(mmol/L) | HDL-c(mmol/L) |
模型组 | - | 8 | 1.23±0.17 | 0.85±0.19 | 0.74±0.13 |
空白对照组 | - | 8 | 0.99±0.12** | 0.65±0.16* | 1.06±0.11*** |
本发明低剂量组 | 1.26 | 8 | 1.28±0.19 | 0.63±0.21* | 0.92±0.23 |
本发明中剂量组 | 2.52 | 8 | 1.01±0.23* | 0.56±0.19** | 0.89±0.13* |
本发明高剂量组 | 5.04 | 8 | 0.89±0.25** | 0.37±0.12*** | 1.03±0.23** |
阳性对照组 | 1.00 | 8 | 0.90±0.31* | 0.46±0.14*** | 0.97±0.19* |
组别 | 给药量(g/kg) | 动物数(只) | T-ch(mmol/L) | TG(mmol/L) |
模型组 | - | 8 | 0.50±0.18 | 1.04±0.24 |
空白对照组 | - | 8 | 0.22±0.11** | 0.49±0.19*** |
本发明低剂量组 | 1.26 | 8 | 0.28±0.18* | 0.98±0.26 |
本发明中剂量组 | 2.52 | 8 | 0.27±0.14* | 0.72±0.19* |
本发明高剂量组 | 5.04 | 8 | 0.26±0.11** | 0.66±0.17** |
阳性对照组 | 1.00 | 8 | 0.24±0.08** | 0.84±0.20*** |
组别 | 给药量(g/kg) | 动物数(只) | 试验前 | 试验后 |
模型组 | - | 10 | 230.5±23.3 | 227.5±21.8 |
空白对照组 | - | 10 | 228.0±25.3 | 238.0±24.9 |
本发明低剂量组 | 1.26 | 10 | 228.0±23.5 | 225.0±18.0 |
本发明中剂量组 | 2.52 | 10 | 231.0±22.8 | 228.5±22.2 |
本发明高剂量组 | 5.04 | 10 | 229.0±24.1 | 237.0±17.0 |
阳性对照组 | 1.00 | 10 | 228.5±24.7 | 220.5±11.9 |
组别 | 给药量(g/kg) | 动物数(只) | 肝脏 | 脾脏 | 胸腺 |
模型组 | - | 10 | 8.76±1.06 | 1.24±0.37 | 0.40±0.12 |
空白对照组 | - | 10 | 6.64±1.65** | 0.92±0.18* | 0.55±0.10** |
本发明低剂量组 | 1.26 | 10 | 7.68±0.62* | 0.98±0.20 | 0.43±0.08 |
本发明中剂量组 | 2.52 | 10 | 7.47±0.54** | 0.96±0.18* | 0.45±0.13 |
本发明高剂量组 | 5.04 | 10 | 7.32±0.83** | 0.86±0.41** | 0.52±0.09* |
阳性对照组 | 1.00 | 10 | 7.28±0.98** | 0.88±0.29* | 0.53±0.12* |
组别 | 给药量(g/kg) | 动物数(只) | T-ch(mmol/L) | TG(mmol/L) | HDL-c(mmol/L) |
模型组 | - | 10 | 0.90±0.17 | 0.84±0.23 | 0.54±0.12 |
空白对照组 | - | 10 | 0.68±0.16** | 0.65±0.17* | 0.75±0.17** |
本发明低剂量组 | 1.26 | 10 | 0.65±0.15** | 0.77±0.12 | 0.57±0.09 |
本发明中剂量组 | 2.52 | 10 | 0.63±0.15** | 0.65±0.16* | 0.64±0.13 |
本发明高剂量组 | 5.04 | 10 | 0.56±0.19*** | 0.61±0.16* | 0.70±0.14* |
阳性对照组 | 1.00 | 10 | 0.59±0.10*** | 0.61±0.12* | 0.69±0.17* |
组别 | 给药量(g/kg) | 动物数(只) | T-ch(mmol/L) | TG(mmol/L) |
模型组 | - | 10 | 0.66±0.10 | 0.65±0.14 |
空白对照组 | - | 10 | 0.52±0.11** | 0.40±0.08*** |
本发明低剂量组 | 1.26 | 10 | 0.53±0.15* | 0.50±0.16* |
本发明中剂量组 | 2.52 | 10 | 0.49±0.13** | 0.46±0.20* |
本发明高剂量组 | 5.04 | 10 | 0.43±0.17** | 0.45±0.13** |
阳性对照组 | 1.00 | 10 | 0.49±0.11** | 0.50±0.18* |
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100146866A CN1244339C (zh) | 2004-04-19 | 2004-04-19 | 一种治疗和预防脂肪肝的中药及其制备工艺 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2004100146866A CN1244339C (zh) | 2004-04-19 | 2004-04-19 | 一种治疗和预防脂肪肝的中药及其制备工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1562139A CN1562139A (zh) | 2005-01-12 |
CN1244339C true CN1244339C (zh) | 2006-03-08 |
Family
ID=34478524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100146866A Expired - Lifetime CN1244339C (zh) | 2004-04-19 | 2004-04-19 | 一种治疗和预防脂肪肝的中药及其制备工艺 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN1244339C (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100340267C (zh) * | 2005-12-13 | 2007-10-03 | 中山市中医院 | 一种治疗脂肪肝的中药制剂 |
CN101987188B (zh) * | 2010-11-19 | 2012-05-30 | 何明华 | 一种用于预防和治疗高血脂症的生物中成药 |
-
2004
- 2004-04-19 CN CNB2004100146866A patent/CN1244339C/zh not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
CN1562139A (zh) | 2005-01-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101053621A (zh) | 一种治疗肥胖症的中药组合物及其制备方法 | |
CN1911421A (zh) | 治疗脂肪肝的调脂益肝药物 | |
CN1256133C (zh) | 一种抗疲劳的中药组合物及其制备方法 | |
CN1293898C (zh) | 治疗病毒性肝炎的药物组合物的制备方法 | |
CN1695730A (zh) | 一种治疗高血脂症的中药组合物及其制备方法 | |
CN1244339C (zh) | 一种治疗和预防脂肪肝的中药及其制备工艺 | |
CN1618441A (zh) | 一种具有调节血脂作用的药物组合物及其制备方法和用途 | |
CN100340286C (zh) | 一种治疗乙型肝炎的药物及其制备方法 | |
CN1772257A (zh) | 三七脂肝制剂及其制备方法 | |
CN1520831A (zh) | 养生护肝药物及其制备方法 | |
CN1692938A (zh) | 一种用于明目的中药复方制剂及其制备方法 | |
CN1264540C (zh) | 治疗急性黄疸肝炎的中药及其制备方法 | |
CN1058165C (zh) | 一种治疗乙型肝炎的中药制剂及其制备方法 | |
CN102940747B (zh) | 治疗痛风的药物组合物 | |
CN1235613C (zh) | 一种促进胃肠功能的药物及其制备方法 | |
CN1294980C (zh) | 一种治疗肝病的药 | |
CN105727089A (zh) | 含艾叶的药物组合物用于制备治疗肠易激综合症药物中的用途 | |
CN1899385A (zh) | 一种治疗慢性肾功能衰竭中药复方注射剂的制备工艺以及应用 | |
CN1814131A (zh) | 一种治疗便秘的中药及其制备方法 | |
CN1251745C (zh) | 一种治疗肝胆疾病的药物及其制备方法 | |
CN1679887A (zh) | 一种治疗肝炎的中药组合物 | |
CN116966222B (zh) | 一种治疗肝纤维化的中药组合物及其制剂和应用 | |
CN1282475C (zh) | 一种治疗胆囊疾病的药物组合物及其制备方法 | |
CN1471954A (zh) | 一种中药戒毒药物 | |
CN102631486B (zh) | 一种保健组合物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NEIMENGGU FURUIZHONG MENGYAO SCIENCE CO., LTD. Free format text: FORMER OWNER: TIANZHAO PHARMACEUTICAL IND CO., LTD., HUAI'AN Effective date: 20070302 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20070302 Address after: 012000 No. 103, Jiefang Road, Jining District, Inner Mongolia, Wulanchabu Patentee after: INNER MONGOLIA FURUI CHINESE & MONGOLIAN TRADITIONAL MEDICINE SCIENCE & TECHNOLOGY STOCK Co.,Ltd. Address before: 210007, Nanjing Garden Street, Jiangsu, 28 Garden Patentee before: Huaian Tianzhao Pharmaceutical Co.,Ltd. |
|
C56 | Change in the name or address of the patentee |
Owner name: INNER MONGOLIA FURUI MEDICAL SCIENCE CO., LTD. Free format text: FORMER NAME: INNER MONGOLIA FREE HAN + MONGOLIA PHARMACEUTICAL TECHNOLOGY CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 012000 No. 103, Jiefang Road, Jining District, Inner Mongolia, Wulanchabu Patentee after: INNER MONGOLIA FURUI MEDICAL SCIENCE Co.,Ltd. Address before: 012000 No. 103, Jiefang Road, Jining District, Inner Mongolia, Wulanchabu Patentee before: INNER MONGOLIA FURUI CHINESE & MONGOLIAN TRADITIONAL MEDICINE SCIENCE & TECHNOLOGY STOCK Co.,Ltd. |
|
CX01 | Expiry of patent term |
Granted publication date: 20060308 |
|
CX01 | Expiry of patent term |