CN1234370C - 一种治疗心血管疾病和休克急救的中药注射剂 - Google Patents
一种治疗心血管疾病和休克急救的中药注射剂 Download PDFInfo
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Abstract
Description
检测时间 | 组别 | 给药前 | 给药后 | |||||
5min | 30min | 60min | 90min | 120min | 180min | |||
MAP(mmHg) | 模型对照对照组 | 105±13 | 102±18 | 103±16 | 101±15 | 102±16 | 98±12 | 101±14 |
本发明冻干粉低剂量 | 107±10 | 115±11 | 126±11* | 121±15* | 121±13* | 122±12** | 118±15* | |
高剂量 | 102±9 | 113±14 | 128±15** | 125±16** | 125±17** | 126±18** | 125±14** | |
参麦注射液 | 103±11 | 109±13 | 122±10* | 119±13* | 122±14* | 121±12** | 120±17* | |
HR(次/min) | 模型对照对照组 | 135±27 | 132±25 | 135±26 | 132±21 | 128±29 | 128±27 | 129±30 |
本发明冻干粉低剂量 | 143±31 | 139±27 | 134±25 | 132±28 | 135±29 | 133±31 | 136±27 | |
高剂量 | 133±24 | 128±21 | 124±24 | 125±21 | 123±26 | 124±22 | 125±21 | |
参麦注射液 | 140±24 | 135±19 | 132±23 | 130±19 | 129±6 | 130±28 | 133±25 | |
CO(L/min) | 模型对照对照组 | 1.10±0.31 | 1.07±0.30 | 1.05±0.32 | 1.06±0.31 | 1.04±0.29 | 1.05±0.30 | 1.06±0.33 |
本发明冻干低剂量 | 1.07±0.17 | 1.10±0.18 | 1.23±0.20 | 1.26±0.22 | 1.25±0.24 | 1.24±0.19 | 1.22±0.23 | |
高剂量 | 1.04±0.24 | 1.09±0.28 | 1.25±0.25 | 1.33±0.27* | 1.32±0.28* | 1.30±0.24* | 1.29±0.27 | |
参麦注射液 | 1.07±0.19 | 1.12±0.22 | 1.22±0.23 | 1.30±0.20* | 1.29±0.21* | 1.29±0.21* | 1.25±0.21 | |
TPVR(mmHg.S/L) | 模型对照对照组 | 883.5±132.2 | 892.2±152.2 | 875.6±121.5 | 884.2±136.8 | 846.6±165.1 | 854.6±141.8 | 861.9±154.2 |
本发明冻干粉低剂量 | 899.7±1 75.6 | 936.2±241.2 | 919.3±218.1 | 889.3±208.6 | 874.6±228.6 | 886.6±253.2 | 873.5±198.2 | |
高剂量 | 884.5±109.5 | 926.3±136.5 | 916.2±108.4 | 952.2±148.6 | 924.5±152.8 | 902.5±95.4 | 875.5±110.7 | |
参麦注射液 | 872.2±86.9 | 879.6±110.2 | 886.2±121.3 | 887.0±1 38.3 | 871.6±154.2 | 828.6±12 8.5 | 847.9±97.8 |
检测指标 | 组别 | 给药前 | 开始给药后 | |||||
5min | 30min | 60min | 90min | 120min | 180min | |||
N-ST | 模型对照 | 10.11±0.85 | 10.55±0.72 | 11.12±0.82 | 11.23±0.72 | 11.66±0.89 | 11.44±0.90 | 10.62±1.37 |
本发明冻干粉低剂量 | 9.95±1.02 | 9.87±0.98 | 8.76±0.85* | 9.31±1.24* | 8.21±0.94* | 8.16±1.19* | 87.12±1.18* | |
高剂量 | 10.89±1.79 | 7.25±2.17 | 4.31±3.25** | 4.12±1.56** | 3.68±1.91** | 4.65±2.65** | 4.83±1.26** | |
参麦注射液 | 11.06±1.29 | 8.21±1.25 | 4.67±1.87** | 3.23±2.18** | 3.12±2.54** | 3.46±2.37** | 3.75+3.62** | |
∑-ST | 模型组 | 4.07±0.39 | 4.66±0.27 | 4.79±0.74 | 4.62±0.97 | 4.57±1.21 | 4.48±0.78 | 4.02±1.11 |
本发明冻干粉低剂量 | 3.06±0.88 | 2.84±0.84 | 2.77±1.12* | 2.47±1.02* | 2.96±1.34** | 2.85±1.03** | 3.12±1.21 | |
高剂量 | 3.05±0.96 | 2.21±0.88 | 1.44±0.98** | 1.39±0.74** | 1.54±0.72** | 1.57±0.60** | 1.77±0.97** | |
参麦注射液 | 3.05±0.67 | 2.32±1.04 | 1.67±1.15** | 1.52±0.90** | 1.68±0.86** | 1.77±0.54** | 1.93±0.78** |
组别 | 心肌梗死范围(%) | LDH | CPK | ||
给药前 | 给药后 | 给药前 | 给药后 | ||
模型对照组 | 23.21±5.21 | 211.2±51.21 | 352.1±68.98 | 598.5±208.75 | 964.6±281.2 |
本发明冻粉低剂量 | 16.18±6.28* | 235.8±50.14 | 251.1±63.72** | 624.9±263.84 | 685.6±302.1** |
中剂量 | 12.46±7.86** | 224.9±48.76 | 219.5±40.82** | 592.5±251.71 | 616.3±232.5** |
参麦注射液 | 14.82±6.82* | 219.3±44.72 | 230.7±53.91** | 619.8±198.76 | 676.9±263.2** |
Claims (3)
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KR101593618B1 (ko) | 2009-05-26 | 2016-02-15 | (주)아모레퍼시픽 | 사포닌의 생체 이용률 증진 조성물 |
CN104623262B (zh) * | 2013-11-12 | 2017-12-19 | 华润三九(雅安)药业有限公司 | 一种参麦注射液及其制备方法 |
CN105267619B (zh) * | 2014-06-07 | 2018-05-01 | 兰州大学 | 一种抑制ras原癌基因过表达的抗肿瘤中药复方提取物 |
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Effective date of registration: 20091016 Address after: North Bank of the Union Hotel, 136 drum Road, Gulou District, Fujian, Fuzhou Province, five Patentee after: Fuzhou Kerry Medical Consulting Co., Ltd. Address before: Room 15, block 506, Lake District, Gulou District, Fujian, Fuzhou Patentee before: Zheng Feixiong |
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Granted publication date: 20060104 Termination date: 20180930 |
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CF01 | Termination of patent right due to non-payment of annual fee |