CN1225814A - 防晒剂组合物 - Google Patents
防晒剂组合物 Download PDFInfo
- Publication number
- CN1225814A CN1225814A CN98126165A CN98126165A CN1225814A CN 1225814 A CN1225814 A CN 1225814A CN 98126165 A CN98126165 A CN 98126165A CN 98126165 A CN98126165 A CN 98126165A CN 1225814 A CN1225814 A CN 1225814A
- Authority
- CN
- China
- Prior art keywords
- weight ratio
- cinnamic acid
- sunscreen composition
- methoxy
- parsol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 238000012216 screening Methods 0.000 title abstract description 5
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Abstract
本发明涉及美容防晒组合物,其中包括至少一个脂相和a)约0.5—5%重量比的二苯甲酰甲烷衍生物,优选0.5—3%重量比;b)约0.5—12%重量比的3,3－二苯基丙烯酸酯衍生物或亚苄基樟脑衍生物,优选0.5—10%重量比;和c)约1—15%重量比的水溶性对—甲氧基肉桂酸盐衍生物,优选1—10%重量比。
Description
本发明涉及保护人体表皮和头发免受波长范围280-320nm(UV-B)和320-400nm(UV-A)紫外线损伤的光稳定性美容防晒组合物。
本发明特别涉及包含二苯甲酰甲烷衍生物作为UV-A防晒剂，3,3-二苯基丙烯酸酯衍生物或亚苄基樟脑衍生物为稳定剂和水溶性对-甲氧基肉桂酸盐衍生物为UV-B防晒剂的美容防晒组合物。
二苯甲酰甲烷衍生物如4-叔-丁基-4′甲氧基-二苯甲酰甲烷(PARSOL1789)能十分显著和有效地吸收高达380nm的UV-A光。然而，当需要吸收宽波长带的UV射线时，没有可以单独使用的UV-A滤光剂。因此，UV-A滤光剂通常必须与UV-B吸收剂合用。最常用的是将4-叔-丁基-4′-甲氧基-二苯甲酰甲烷和2-乙基己基-对-甲氧基肉桂酸盐(PARSOLMCX)合用。美国专利4,387,089描述了这种结合。许多常用制剂包含合用的PARSOL 1789和PARSOLMCX。
由于二苯甲酰甲烷衍生物的光不稳定性，有必要使这些UV-A滤光剂光稳定化。
欧洲专利公开EP-0 514 491 B1中描述了二苯甲酰甲烷衍生物作为UV-A滤光剂和3,3-二苯基丙烯酸酯衍生物为光稳定剂的美容防晒组合物。所述的已知组合物包含至少一个脂相，1-5％重量比的二苯甲酰甲烷衍生物和至少1％重量比的3,3-二苯基丙烯酸酯衍生物。3,3-二苯基丙烯酸酯衍生物与二苯甲酰甲烷衍生物的摩尔比不小于0.8和不大于8。所述的防晒剂组合物可以另外包含水溶性UV-B防晒剂如2-苯基-苯并咪唑-5-磺酸(PARSOLHS)，对-苯二亚甲基-3-3′-二樟脑-10,10′-二磺酸(MEXORYL SX)和水溶性UV-A防晒剂如2-羟基-4甲氧基-苯酮-5-磺酸(UNIVUL MS-40)。然而，没有提及肉桂酸衍生物。
欧洲专利公开EP 0 780 119 A1描述了一种光稳定性美容防晒组合物，包含至少一个脂相，0.1-5％重量比的二苯甲酰甲烷衍生物和作为稳定剂的0.5-4.5％重量比的3,3-二苯基丙烯酸酯衍生物。3,3-二苯基丙烯酸酯衍生物与二苯甲酰甲烷衍生物的摩尔比小于0.8。所述的防晒组合物可另外包含作为UV-B滤光剂的聚硅氧烷衍生物、聚丙烯酸酯衍生物或微细金属氧化物。然而，没有提及肉桂酸衍生物。
在美国专利5,605,680号中描述了基于二苯甲酰甲烷衍生物作为UV-A滤光剂和亚苄基樟脑衍生物为光稳定剂的美容防晒组合物。所述组合物包括至少一个脂相，1-3％重量比的4-叔-丁基-4′-甲氧基-二苯甲酰甲烷和至少4.5％重量比的对-甲基亚苄基樟脑。对-甲基亚苄基樟脑和4-叔-丁基-4′-甲氧基-二苯甲酰甲烷的重量比大于或等于3。该专利出版物中没有提到其它的UV-A或UV-B滤光剂。
大量常用的宽波长带防晒组合物是基于PARSOL MCX和PARSOL1789分别作为基本的UV-A和UV-B滤光剂，其它的UV滤光剂是可有可无的。在多数情况下，如上述欧洲专利公开EP-0 514 491 B1和EP-0 780 119A1，氰双苯丙烯酸辛酯对PARSOL 1789的稳定作用不足。在上述美国专利5,605,680中，对-甲基-苄基樟脑对PARSOL1789的稳定作用也不足。
现在已经发现包含二苯甲酰甲烷衍生物作为UV-A滤光剂，水溶性对-甲氧基-肉桂酸盐衍生物为UV-B滤光剂和3,3-二苯基丙烯酸酯衍生物或亚苄基樟脑衍生物为稳定剂的防晒组合物，相对于含有常用的PARSOLMCX作为UV-B滤光剂的相应的防晒组合物来说，显示出惊人高的光稳定性。
因此，本发明涉及一种美容防晒组合物，其中包括至少一个脂相和a)约0.5-5％重量比的二苯甲酰甲烷衍生物；b)约0.5-12％重量比的3,3-二苯基丙烯酸酯衍生物或亚苄基樟脑衍生物；和c)约1-15％重量比的水溶性对-甲氧基肉桂酸盐衍生物。
本发明中“二苯甲酰甲烷衍生物”一词是指这样一些化合物例如4-叔-丁基-4′-甲氧基-二苯甲酰甲烷、2-甲基二苯甲酰甲烷、4-甲基-二苯甲酰基-乙烷、4-异丙基二苯甲酰基甲烷、4-叔-丁基二苯甲酰甲烷、2,4-二甲基二苯甲酰甲烷、2,5-二甲基二苯甲酰甲烷、4,4′-二异丙基-二苯甲酰甲烷、2-甲基-5-异丙基-4′-甲氧基二苯甲酰甲烷、2-甲基-5-叔-丁基-4′-甲氧基-二苯甲酰甲烷、2,4-二甲基-4′-甲氧基二苯甲酰甲烷和2,6-二甲基-4-叔-丁基-4′-甲氧基-二苯甲酰甲烷。优选4-叔-丁基-4′-甲氧基-二苯甲酰甲烷(PARSOL1789)。
本发明中“3,3-二苯基丙烯酸酯衍生物”一词是指这样一些化合物例如2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯(氰双苯丙烯酸辛酯-octocrylene)和2-乙基-2-氰基-3,3-二苯基丙烯酸酯(氰双苯丙烯酸乙酯-etocrylene)。优选氰双苯丙烯酸辛酯。
本发明中“亚苄基樟脑衍生物”特指对-甲基亚苄基樟脑(PARSOL5000)。
本发明中“水溶性对-甲氧基肉桂酸盐衍生物”是指例如对-甲氧基肉桂酸铵、对-甲氧基肉桂酸钠、对-甲氧基肉桂酸钾，对-甲氧基肉桂酸的伯胺、仲胺和叔胺盐如对-甲氧基肉桂酸单乙醇胺盐、对-甲氧基肉桂酸二乙醇胺盐或对-甲氧基肉桂酸三乙醇胺盐，氨甲基丙醇盐，吗啉盐等。优选单-、二-和三乙醇胺盐。
二苯甲酰甲烷衍生物与水溶性对-甲氧基肉桂酸衍生物及二苯甲酰甲烷衍生物与3,3-二苯基丙烯酸酯衍生物或与亚苄基樟脑衍生物的摩尔或重量比是不严格的。优选下列浓度：
a)约1-3％重量比的二苯甲酰甲烷衍生物；
b)约0.5-10％重量比的3,3-二苯基丙烯酸酯衍生物或亚苄基樟脑衍生物；和
c)约1-10％重量比的水溶性对-甲氧基肉桂酸盐衍生物。
用作UV-A滤光剂的二苯甲酰甲烷衍生物和用作稳定剂的3,3-二苯基丙烯酸酯衍生物均为亲脂性的。这样，该美容防晒剂组合物包含至少一种脂相，因而它们自身可以乳剂、乳液或凝胶的形式存在。
本发明的防晒组合物的化妆品基质可以是符合化妆品需求的任何常用制剂，例如油、乳液、膏霜、乳剂、凝胶、固体棒剂、气溶胶、喷雾剂、泡沫、粉剂、香波、头发调理剂、敷剂或粉底等形式。
熟练技术人员可将熟知的普通基质化合物用于这些形式的制剂，这些基质化合物如油、蜡、醇、多元醇等。优选的化合物是脂肪酸、脂肪酸酯、脂肪醇，也可是乙醇、异丙醇、丙二醇、甘油等。
化妆品组合物可包含其它辅助剂，如其它溶剂、增稠剂、润肤剂、乳化剂、保湿剂、表面活性剂、防腐剂、消泡剂、香料、油、蜡、低级多元醇和单羟基醇、推进剂、硅酮、着色剂和颜料等。
用于保护头发的适宜制剂是香波、调理剂、乳液、凝胶、乳剂、喷发剂、发蜡等。
此外，可加入单体或聚合的UV滤光剂。
适宜的UV-B滤光剂(即最大吸收在290-320nm的物质)是例如下列属于最广义类型的有机化合物：
---对氨基苯甲酸衍生物如对氨基苯甲酸乙酯、氨基苯甲酸丙酯、氨基苯甲酸丁酯和氨基苯甲酸异丁酯等；
---丙烯酸酯如2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯(氰双苯丙烯酸辛酯)，乙基-2-氰基-3,3-二苯基丙烯酸酯等；
---苯胺衍生物如甲基苯胺硫酸甲酯等；
---邻氨基苯甲酸衍生物如邻氨基苯甲酸薄荷醇酯等；
---苯酮衍生物如苯酮-3，苯酮-4等；
---樟脑衍生物如甲基亚苄基樟脑等；
---肉桂酸酯衍生物例如甲氧基肉桂酸辛酯或甲氧基肉桂酸乙氧酯也可以是与硅氧烷键合的肉桂酸衍生物；
---没食子酸如双棓酰三油酸酯等；
---咪唑衍生物如苯基苯并咪唑磺酸；
---水杨酸酯衍生物如水杨酸辛酯，水杨酸高薄荷醇酯等；
---***衍生物如羟苯基苯***等；
---***酮衍生物如***酮辛酯等；和
---颜料如二氧化钛、氧化锌微粒等。适宜的聚合滤光剂是在欧洲专利公开EP 538431 B1中描述的聚硅氧烷。
组合物可以另外包含UV-A滤光剂，例如在欧洲专利公开EP 0693483A1、EP 0704437 A2、EP 0704444 A1和EP 0780382 A1中描述的三嗪化合物。
所有这些组合物的制备是本领域技术人员所熟知的。
正如欧洲专利公开EP 0 780 119 A1中描述的那样，有时要求稳定剂的用量小于UV-A滤光剂的剂量。因此，优选3,3-二苯基丙烯酸酯衍生物与二苯甲酰甲烷衍生物的摩尔比小于0.8和优选对-甲基亚苄基樟脑与二苯甲酰甲烷衍生物的重量比小于3。
下列实施例描述本发明提供的防晒剂。
实施例中的缩写和选用的商品名具有如下定义：PARSOL1789 4-叔-丁基-4′-甲氧基-二苯甲酰甲烷，由Roche.以商品名
PARSOL1789出售PARSOL MCX 2-乙基己基-对-甲氧基肉桂酸盐，由Roche.以商品名
PARSOL MCX出售氢化PARSOL 对-甲氧基肉桂酸的二乙醇胺盐，由Roche.以商品名氢化
PARSOL出售PARSOL 5000 对-甲基亚苄基樟脑，由Roche.以商品名PARSOL 5000出
售UNIVULN-539 2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯(氰双苯丙烯酸辛
酯)，由BASF.商品名UNIVUL N-539出售CETIOL LC： 椰油基-辛酸酯-癸酸酯，由Henkel.以商品名CETIOL LC
出售GANEX V 220 聚乙烯基吡咯烷酮/二十八碳烯共聚物，由ISP.以商品名
GANEX V 220出售MIGLYOL 812 N 辛癸酸三甘油酯，由Huls.以商品名MIGLYOL 812 N出
售BHT 丁基羟甲苯(2,6二-叔-丁基-4-甲苯)EDTA 乙二胺四乙酸二钠盐PHENONIP 4-羟苯甲酸酯混合物，由NIPA有限公司以商品名
PHENONIP出售LNETIE 0 鲸蜡硬脂醇，由Henkel.以商品名LANETITE 0出售CUTINAE24 硬脂酸甘油酯，由Henkel.以商品名CUTINAE24出售CARBOPOL 981 卡波姆981(10.0％与蔗糖烯丙醚交联的丙烯酸均聚物的1
％浓度水溶液)，由B.F.Goodrich.以商品名CARBOPOL
981出售ARLAMOL E POP-(15)-硬脂酰乙酯由ICI.出品ARLAMOLHD 环庚基壬烷，由ICI.出品BRIJ 72 POE-(2)-硬脂酰乙酯，由ICI.出品BRIJ 72 POE-(21)-硬脂酰乙酯，由ICI.出品ARLACEL P135 PEG-30二多羟基硬脂酸酯，由ICI.出售硬脂酸 硬脂酸，由Unichema.出品Silbione油 cyclomethicone，由Rhone Poulenc.出品70047 V20Keltrol 黄原胶由BASF.出品Umordant P 水，乳酸钠，PCA钠，脲，水解植物蛋白和天门冬属提取
物以及磷酸钠，由Cosmetochem.出品
实施例3A、3B、4、5、6、7、8A、10A-C、11、12、13B、13C中描述的对-甲氧基肉桂酸盐是通过将对-甲氧基肉桂酸与适合的碱在足够的溶剂中混合并结晶纯化而制备。
实施例1A和1B是含有氰双苯丙烯酸辛酯作稳定剂和PARSOL MCX替代水溶性对-甲氧基-肉桂酸盐作为UV-B滤光剂的对照例。
实施例1C是含有PARSOL 5000作稳定剂和PARSOL MCX替代水溶性对-甲氧基-肉桂酸盐作为UV-B滤光剂的对照例。
实施例2-8指含氰双苯丙烯酸辛酯为稳定剂本发明化合物。
实施例9-13指含PARSOL 5000为稳定剂的本发明化合物。
实施例14显示光稳定性数据。
实施例1A和1B(对照例)
含有如下表所示不同量的PARSOL MCX和UNIVUL N-539的防晒乳液：
组分％重量比 1Aa 1Ab 1Ac 1Ad 1Ae 1Af1 PARSOL 1789 2.5 2.5 2.5 2.5 2.5 2.52 肉蔻酸单甘油酯 4.0 4.0 4.0 4.0 4.0 4.03 CETIOLLC 5.0 5.0 5.0 5.0 5.0 5.04 GANEXV220 2.0 2.0 2.0 2.0 2.0 2.05 鲸蜡醇 2.0 2.0 2.0 2.0 2.0 2.06 MIGLYOL 812 N 10.0 10.0 10.0 10.0 10.0 10.07 BHT 0.1 0.1 0.1 0.1 0.1 0.18 PHENONIP 0.6 0.6 0.6 0.6 0.6 0.69 PARSOL MCX 8.0 8.0 8.0 4.0 4.0 4.010 UNIVUL N-539 2.0 5.0 8.0 2.0 5.0 8.011 LANETTE 0 5.0 5.0 5.0 5.0 5.0 5.012 CUTINA E 24 4.0 4.0 4.0 4.0 4.0 4.013 丙二醇 10.0 10.0 10.0 10.0 10.0 10.014 EDTA 0.1 0.1 0.1 0.1 0.1 0.115 CARBOPOL 981(1％溶 10.0 10.0 10.0 10.0 10.0 10.0
液)16 去矿物质水 100 100 100 100 100 10017 氢氧化钾调节pH 7 7 7 7 7 7方法：在搅拌状态下将组分1-12加热到85℃。混合过程中加入预热到75℃的均质组分13-16。将混合物冷却到40℃。用氢氧化钾调整pH为7。补充损失水分并在搅拌状态下将混合物冷却至室温。
实施例1B(对照例)组分％重量比 1Ba 1Bb 1Bc 1Bd 1Be 1Bf1 PARSOL MCX 8.0 8.0 8,0 4.0 4.0 4.02 PARSOL 1789 2.5 2.5 2.5 2.5 2.5 2.53 UNIVAL N 539 8.0 5.0 2.0 8.0 5.0 2.04 Arlamol E 5.0 5.0 5.0 5.0 5.0 5.05 Arlamol HD 5.0 5.0 5.0 5.0 5.0 5.06 Brij 72 3.0 3.0 3.0 3.0 3.0 3.07 Brij 721 2.0 2.0 2.0 2.0 2.0 2.08 Arlacel P135 0.5 0.5 0.5 0.5 0.5 0.59 Lanette 0 5.0 5.0 5.0 5.0 5.0 5.010硬脂酸 1.5 1.5 1.5 1.5 1.5 1.511Silbione油70047V20 1.0 1.0 1.0 1.0 1.0 1.012BHT 0.1 0.1 0.1 0.1 0.1 0.113Phenonip 0.6 0.6 0.6 0.6 0.6 0.614Keltrol1％溶液浓度 12.0 12.0 12.0 12.0 12.0 12.015丙二醇 4.0 4.0 4.0 4.0 4.0 4.016Umordant P 1.0 1.0 1.0 1.0 1.0 1.017去离子水加至 100 100 100 100 100 100方法：
在搅拌状态下将组分1-13加热到85℃。加入预热到75℃的均质组分14-17。补充损失水分并在搅拌状态下将混合物冷却至室温。
实施例1C(对照例)
含有如下表所示不同量的PARSOL MCX和PARSOL 5000的本发明的防晒乳剂：组分％重量比 1Ca 1Cb 1Cc 1Cd 1Ce 1Cf1 PARSOL MCX 8.0 8.0 8.0 4.0 4.0 4.02 PARSOL 1789 2.5 2.5 2.5 2.5 2.5 2.53 PARSOL 5000 8.0 5.0 2.0 8.0 5.0 2.04 Arlamol E 5.0 5.0 5.0 5.0 5.0 5.05 Arlamol HD 5.0 5.0 5.0 5.0 5.0 5.06 Brij 72 3.0 3.0 3.0 3.0 3.0 3.07 Brij 721 2.0 2.0 2.0 2.0 2.0 2.08 Arlacel P135 0.5 0.5 0.5 0.5 0.5 0.59 Lanette 0 5.0 5.0 5.0 5.0 5.0 5.010 硬脂酸 1.5 1.5 1.5 1.5 1.5 1.511 Silbione 油1.0 1.0 1.0 1.0 1.0 1.070047V2012 BHT 0.1 0.1 0.1 0.1 0.1 0.113 Phenonip 0.6 0.6 0.6 0.6 0.6 0.614 Keltrol1％溶液浓度 12.0 12.0 12.0 12.0 12.0 12.015 丙二醇 4.0 4.0 4.0 4.0 4.0 4.016 Umordant P 1.0 1.0 1.0 1.0 1.0 1.017 去离子水加至 100 100 100 100 100 100
按照实施例1B的方法制备。
实施例2A和2B
含有如下表所示不同量的氢化PARSOL和UNIVUL N-539(氰双苯丙烯酸辛酯)的本发明的防晒乳液：
实施例2A组分％重量比 2Aa 2Ab 2Ac 2Ad1 PARSOL 1789 2.5 2.5 2.5 2.52 肉蔻酸单甘油酯 4.0 4.0 4.0 4.03 CETIOLLC 2.0 2.0 2.0 2.04 GANEXV 220 2.0 2.0 2.0 2.05 鲸蜡醇 2.0 2.0 2.0 2.06 MIGLYOL 812N 10.0 10.0 10.0 10.07 BHT 0.1 0.1 0.1 0.18 PHENONIP 0.6 0.6 0.6 0.69 UNIVUL N-539 5.0 8.0 5.0 8.010LANETTE 0 5.0 5.0 5.0 5.011CUTINA E 24 4.0 4.0 4.0 4.012氢化PARSOL 8.0 8.0 4.0 4.013丙二醇 10.0 10.0 10.0 10.014EDTA 0.1 0.1 0.1 0.115CARBOPOL 981(1％溶 10.0 10.0 10.0 10.0
液)16去矿物质水适量 34.7 34.7 38.7 38.717二乙醇胺适量调pH 7 7 7 7方法：在搅拌状态下将组分1-11加热到85℃。一边混合一边加入预热到75℃的均质组分12-16。将混合物冷却到40℃。用二乙醇胺调整pH值为7。补充损失水分并在搅拌状态下将混合物冷却至室温。
实施例2B组分％重量比 2Ba 2Bb 2Bc 2Bd1 PARSOL 1789 2.5 2.5 2.5 2.52 UNIVAL N-539 8.0 5.0 8.0 5.03 Arlamol E 5.0 5.0 5.0 5.04 Arlamol HD 5.0 5.0 5.0 5.05 Brij 72 3.0 3.0 3.0 3.06 Brij 721 2.0 2.0 2.0 2.07 Arlacel P135 0.5 0.5 0.5 0.58 Lanette 0 5.0 5.0 5.0 5.09 硬脂酸 1.5 1.5 1.5 1.510 Silbione油70047V20 1.0 1.0 1.0 1.011 BHT 0.1 0.1 0.1 0.112 Phenonip 0.6 0.6 0.6 0.613 氢化PARSOL 8.0 8.0 4.0 4.014 Keltrol1％溶液浓度 12.0 12.0 12.0 12.015 丙二醇 4.0 4.0 4.0 4.016 Unmordant P 1.0 1.0 1.0 1.017 去离子水加至 100 100 100 100方法：在搅拌状态下将组分1-12加热到85℃。将预热到75℃的均质组分13-17加入到有机相中。然后将乳液冷却至40℃。补充损失水分并在搅拌状态下将混合物冷却至室温。
实施例3A和3B
含有如下表所示不同量的对-甲氧基肉桂酸钾盐和UNIVULN-539(氰双苯丙烯酸辛酯)的本发明的防晒乳液：
实施例3A组分％重量比 3Aa 3Ab 3Ac 3Ad1 PARSOL 1789 2.5 2.5 2.5 2.52 单肉蔻酸甘油酯 4.0 4.0 4.0 4.03 CETIOLLC 2.0 2.0 2.0 2.04 GANEX V 220 2.0 2.0 2.0 2.05 鲸蜡醇 2.0 2.0 2.0 2.06 MIGLYOL 812 N 10.0 10.0 10.0 10.07 BHT 0.1 0.1 0.1 0.18 PHENONIP 0.6 0.6 0.6 0.69 UNIVUL N-539 5.0 8.0 5.0 8.010 LANETTE 0 5.0 5.0 5.0 5.011 CUTINAE 24 4.0 4.0 4.0 4.012 对-甲氧基肉桂酸钾盐 8.0 8.0 4.0 4.013 丙二醇 10.0 10.0 10.0 10.014 EDTA 0.1 0.1 0.1 0.115 CARBOPOL 981(1％溶 10.0 10.0 10.0 10.0
液)16 去矿物质水适量 34.7 34.7 38.7 38.717 氢氧化钾适量调pH 7 7 7 7方法：按照实施例2A的方法。
实施例3B组分％重量比 3Ba 3Bb 3Bc 3Bd1 PARSOL 1789 2.5 2.5 2.5 2.52 UNIVALN-539 8.0 5.0 8.0 5.03 Arlamol E 5.0 5.0 5.0 5.04 Arlamol HD 5.0 5.0 5.0 5.05 Brij 72 3.0 3.0 3.0 3.06 Brij 721 2.0 2.0 2.0 2.07 Arlacel P135 0.5 0.5 0.5 0.58 Lanette 0 5.0 5.0 5.0 5.09 硬脂酸 1.5 1.5 1.5 1.510Silbione油70047V20 1.0 1.0 1.0 1.011BHT 0.1 0.1 0.1 0.112Phenonip 0.6 0.6 0.6 0.613对-甲氧基肉桂酸钾盐 8.0 8.0 4.0 4.014Keltrol 1％溶液浓度 12.0 12.0 12.0 12.015丙二醇 4.0 4.0 4.0 4.016Unmordant P 1.0 1.0 1.0 1.017去离子水加至 100 100 100 100方法：按照实施例2B的方法。
实施例4
含有如下表所示不同量的对-甲氧基肉桂酸钠盐和UNIVUL N-539(氰双苯丙烯酸辛酯)的本发明的防晒乳液：
组分％重量比 4a 4b1 PARSOL 1789 2.5 2.52 单肉蔻酸甘油酯 4.0 4.03 CETIOLLC 2.0 2.04 GANEX V 220 2.0 2.05 鲸蜡醇 2.0 2.06 MIGLYOL 812N 10.0 10.07 BHT 0.1 0.18 PHENONIP 0.6 0.69 UNIVUL N-539 5.0 8.010 LANETTE 0 5.0 5.011 CUTINAE 24 4.0 4.012 对-甲氧基肉桂酸钠盐 4.0 4.013 丙二醇 10.0 10.014 EDTA 0.1 0.115 CARBOPOL 981(1％溶液) 10.0 10.016 去矿物质水适量 38.7 35.717 氢氧化钠适量调pH 7 7方法：按照实施例2A的方法。
实施例5
含有如下表所示不同量的对-甲氧基肉桂酸单乙醇铵盐和氰双苯丙烯酸辛酯(UNIVULN-539)的本发明的防晒乳液：组分％重量比 5a 5b 5c 5d1 PARSOL 1789 2.5 2.5 2.5 2.52 UNIVALN-539 8.0 5.0 8.0 5.03 Arlamol E 5.0 5.0 5.0 5.04 Arlamol HD 5.0 5.0 5.0 5.05 Brij 72 3.0 3.0 3.0 3.06 Brij 721 2.0 2.0 2.0 2.07 Arlacel P135 0.5 0.5 0.5 0.58 Lanette 0 5.0 5.0 5.0 5.09 硬脂酸 1.5 1.5 1.5 1.510 Silbione油70047V20 1.0 1.0 1.0 1.011 BHT 0.1 0.1 0.1 0.112 Phenonip 0.6 0.6 0.6 0.613 对-甲氧基肉桂酸单乙醇铵盐 8.0 8.0 4.0 4.014 Keltrol 1％溶液浓度 12.0 12.0 12.0 12.015 丙二醇 4.0 4.0 4.0 4.016 Unmordant P 1.0 1.0 1.0 1.017 去离子水加至 100 100 100 100方法：按照实施例2B的方法。
实施例6
含有如下表所示不同量的对-甲氧基肉桂酸铵盐和UNIVUL N-539(氰双苯丙烯酸辛酯)的本发明的防晒乳液：
组分％重量比 6a 6b1 PARSOL 1789 2.5 2.52 单肉蔻酸甘油酯 4.0 4.03 CETIOL LC 2.0 2.04 GANEX V 220 2.0 2.05 鲸蜡醇 2.0 2.06 MIGLYOL 812N 10.0 10.07 BHT 0.1 0.18 PHENONIP 0.6 0.69 UNIVUL N-539 5.0 8.010 LANETTE 0 5.0 5.011 CUTINAE24 4.0 4.012 对-甲氧基肉桂酸铵盐 4.0 4.013 丙二醇 10.0 10.014 EDTA 0.1 0.115 CARBOPOL 981(1％溶液) 10.0 10.016 去矿物质水适量 38.7 35.717 氢氧化氨适量调pH 7 7方法：同实施例2A。
实施例7
含有如下表所示不同量的对-甲氧基肉桂酸三乙醇铵盐和氰双苯丙烯酸辛酯(UNIVUL N-539)的本发明的防晒乳剂：组分％重量比 7a 7b 7c 7d1 PARSOL 1789 2.5 2.5 2.5 2.52 UNIVAIN-539 8.0 5.0 8.0 5.03 Arlamol E 5.0 5.0 5.0 5.04 Arlamol HD 5.0 5.0 5.0 5.05 Brij 72 3.0 3.0 3.0 3.06 Brij 721 2.0 2.0 2.0 2.07 Arlacel P135 0.5 0.5 0.5 0.58 Lanette 0 5.0 5.0 5.0 5.09 硬脂酸 1.5 1.5 1.5 1.510 Silbione油70047V20 1.0 1.0 1.0 1.011 BHT 0.1 0.1 0.1 0.112 Phenonip 0.6 0.6 0.6 0.613 对-甲氧基肉桂酸三乙醇胺盐 8.0 8.0 4.0 4.014 Keltrol 1％溶液浓度 12.0 12.0 12.0 12.015 丙二醇 4.0 4.0 4.0 4.016 Umordant P 1.0 1.0 1.0 1.017 去离子水加至 100 100 100 100方法：按照实施例2B的方法。
实施例8A和8B
有不同量的氢化PARSOL或对-甲氧基肉桂酸盐和UNIVUL N-539的防晒乳液，其中UNIVUL N 539与PARSOL 1789的克分子比小于0.8，见下表：
实施例8A组分％重量比 8Aa 8Ab 8Ac 8Ad 8Ae 8Af1 PARSOL 1789 2.5 2.5 2.5 2.5 2.5 2.52 肉蔻酸单甘油酯 4.0 4.0 4.0 4.0 4.0 4.03 CETIOLLC 2.0 2.0 2.0 2.0 2.0 2.04 GANEXV220 2.0 2.0 2.0 2.0 2.0 2.05 鲸蜡醇 2.0 2.0 2.0 2.0 2.0 2.06 MIGLYOL 812 N 10.0 10.0 10.0 10.0 10.0 10.07 BHT 0.1 0.1 0.1 0.1 0.1 0.18 PHENONIP 0.6 0.6 0.6 0.6 0.6 0.69 UNIVUL N-539 2.0 2.0 2.0 2.0 2.0 2.010 LANETTE 0 5.0 5.0 5.0 5.0 5.0 5.011 CUTINA E 24 4.0 4.0 4.0 4.0 4.0 4.012 氢化PARSOL 8.0 4.0
对-甲氧基肉桂酸钾盐 8.0 4.0
对-甲氧基肉桂酸钠盐 4.0
对-甲氧基肉桂酸铵盐 4.013 丙二醇 10.0 10.0 10.0 10.0 10.0 10.014 EDTA 0.1 0.1 0.1 0.1 0.1 0.115 CARBOPOL 981(1％溶液) 10.0 10.0 10.0 10.0 10.0 10.016 去矿物质水适量 37.7 41.7 29.7 33.7 33.7 33.717 氢氧化钾或氢氧化钠或氢氧化铵 7 7 7 7 7 7
适量调节pH方法：按照实施例2A的方法。
实施例8B组分％重量比 8Ba 8Bb 8Bc 8Bd 8Be 8Bf 8Bg 8Bh1 PARSOL 1789 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.52 UNIVALN539 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.03 Arlamol E 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.04 Arlamol HD 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.05 Brij 72 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.06 Brij 721 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.07 Arlacel P135 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.58 Lanette 0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.09 硬脂酸 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.510 Silbione油70047V20 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.011 BHT 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.112 Phenonip 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.613 氢化PARSOL或 8.0 4.013 对-甲氧基肉桂酸三乙醇 8.0 4.0铵盐13 对-甲氧基肉桂酸单乙 8.0 4.0醇铵盐13 对-甲氧基肉桂酸钾盐 8.0 4.014 Keltrol 1％溶液浓度 12.0 12.0 12.0 12.0 12.0 12.0 12.0 12.015 丙二醇 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.016 Umordant P 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.017 去离子水 100 100 100 100 100 100 100 100方法：按照实施例2B的方法。
实施例9A和9B
含有如下表所示不同量的氢化PARSOL和PARSOL 5000的本发明的防晒乳液：
实施例9A
组分％重量比 9Aa 9Bb1 PARSOL 1789 2.5 2.52 肉蔻酸单甘油酯 4.0 4.03 CETIOLLC 2.0 2.04 GANEX V 220 2.0 2.05 鲸蜡醇 2.0 2.06 MIGLYOL 812 N 10.0 10.07 BHT 0.1 0.18 PHENONIP 0.6 0.69 PARSOL 5000 8.0 8.010 LANETTE 0 5.0 5.011 CUTINA E 24 4.0 4.012 氢化PARSOL 8.0 4.013 丙二醇 10.0 10.014 EDTA 0.1 0.115 CARBOPOL 981(1％溶液) 10.0 10.016 去矿物质水适量 34.7 31.717 二乙醇铵适量调pH 7 7方法：按照实施例2A的方法。
实施例9B
组分％重量比 9Ba 9Bb1 PARSOL 1789 2.5 2.52 PARSOL 5000 8.0 8.03 Arlamol E 5.0 5.04 Arlamol HD 5.0 5.05 Brii 72 3.0 3.06 Brij 721 2.0 2.07 Arlacel P135 0.5 0.58 Lanette 0 5.0 5.09 硬脂酸 1.5 1.510 Silbione油70047V20 1.0 1.011 BHT 0.1 0.112 Phenonip 0.6 0.613 氢化PARSOL 8.0 4.014 Keltrol 1％溶液浓度 12.0 12.015 丙二醇 4.0 4.016 Umordant P 1.0 1.017 去离子水加至 100 100方法：按照实施例2B的方法。
实施例10A、10B和10C
含有如下表所示不同量的对-甲氧基肉桂酸钾盐和PARSOL 5000的本发明的防晒乳液：
实施例10A组分％重量比 10Aa 10Bb1 PARSOL 1789 2.5 2.52 单肉蔻酸甘油酯 4.0 4.03 CETIOLLC 2.0 2.04 GANEX V 220 2.0 2.05 鲸蜡醇 2.0 2.06 MIGLYOL 812 N 10.0 10.07 BHT 0.1 0.18 PHENONIP 0.6 0.69 PARSOL 5000 8.0 8.010 LANETTE 0 5.0 5.011 CUTINA E 24 4.0 4.012 对-甲氧基肉桂酸钾盐 8.0 4.013 丙二醇 10.0 10.014 EDTA 0.1 0.115 CARBOPOL 981(1％溶液) 10.0 10.016 去矿物质水适量 34.7 31.717 氢氧化钾适量调pH 7 7方法：按照实施例2A的方法。
实施例10B组分％重量比 10Ba 10Bb1 PARSOL 1789 2.5 2.52 PARSOL 5000 8.0 8.03 Arlamol E 5.0 5.04 Arlamol HD 5.0 5.05 Brij 72 3.0 3.06 Brij 721 2.0 2.07 Arlacel P135 0.5 0.58 Lanette 0 5.0 5.09 硬脂酸 1.5 1.510 Silbione油70047V20 1.0 1.011 BHT 0.1 0.112 Phenonip 0.6 0.613 对-甲氧基肉桂酸钾盐 8.0 4.014 Keltrol 1％溶液浓度 12.0 12.015 丙二醇 4.0 4.016 Umordant P 1.0 1.017 去离子水加至 100 100方法：按照实施例2B的方法。
实施例10C 组分％重量比 10Ca 10Cb 10Cc 10Cd1 PARSOL 1789 2.5 2.5 2.5 2.52 肉蔻酸单甘油酯 4.0 4.0 4.0 4.03 CETIOL LC 2.0 2.0 2.0 2.04 GANEXV 220 2.0 2.0 2.0 2.05 鲸蜡醇 2.0 2.0 2.0 2.06 MIGLYOL 812 N 10.0 10.0 10.0 10.07 BHT 0.1 0.1 0.1 0.18 PHENONIP 0.6 0.6 0.6 0.69 PARSOL 5000 2.0 5.0 2.0 5.010 LANETTE 0 5.0 5.0 5.0 5.011 CUTINAE 24 4.0 4.0 4.0 4.012 对-甲氧基肉桂酸钾盐 4.0 4.0 4.0 4.013 丙二醇 10.0 10.0 10.0 10.014 EDTA 0.1 0.1 0.1 0.115 CARBOPOL 981(1％溶液) 10.0 10.0 10.0 10.016 去矿物质水适量 37.7 34.7 41.7 38.717 氢氧化钾适量调pH 7 7 7 7方法：按照实施例2A。
实施例11
含有如下表所示不同量的对-甲氧基肉桂酸单乙醇铵盐和PARSOL 5000的本发明的防晒乳液：组分％重量比 11a 11b1 PARSOL 1789 2.5 2.52 PARSOL 5000 8.0 8.03 Arlamol E 5.0 5.04 Arlamol HD 5.0 5.05 Brij 72 3.0 3.06 Brij 721 2.0 2.07 Arlacel P135 0.5 0.58 Lanette 0 5.0 5.09 硬脂酸 1.5 1.510 Silbione油70047V20 1.0 1.011 BHT 0.1 0.112 Phenonip 0.6 0.613 对-甲氧基肉桂酸单乙醇胺盐 8.0 4.014 Keltrol 1％溶液浓度 12.0 12.015 丙二醇 4.0 4.016 Umordant P 1.0 1.017 去离子水加至 100 100方法：按照实施例2B的方法。
实施例12
含有如下表所示不同量的对-甲氧基肉桂酸三乙醇铵盐和PARSOL 5000的本发明的防晒乳液：组分％重量比 12a 12b1 PARSOL 1789 2.5 2.52 PARSOL 5000 8.0 8.03 Arlamol E 5.0 5.04 Arlamol HD 5.0 5.05 Brij 72 3.0 3.06 Brij 721 2.0 2.07 Arlacel P135 0.5 0.58 Lanette 0 5.0 5.09 硬脂酸 1.5 1.510 Silbione油70047V20 1.0 1.011 BHT 0.1 0.112 Phenonip 0.6 0.613 对-甲氧基肉桂酸单三乙醇胺盐 8.0 4.014 Keltrol 1％溶液浓度 12.0 12.015 丙二醇 4.0 4.016 Umordant P 1.0 1.017 去离子水加至 100 100方法：按照实施例2B的方法。
实施例13A、13B和13C
含有不同量的氢化PARSOL或对-甲氧基肉桂酸盐和PARSOL 5000的本发明的防晒乳液，其中PARSOL 5000与PARSOL 1789的重量比小于3，见下表：
实施例13A组分％重量比 13Aa 13Ab 13Ac 13Ad1 PARSOL 1789 2.5 2.5 2.5 2.52 肉蔻酸单甘油酯 4.0 4.0 4.0 4.03 CETIOLLC 2.0 2.0 2.0 2.04 GANEXV220 2.0 2.0 2.0 2.05 鲸蜡醇 2.0 2.0 2.0 2.06 MIGLYOL 812 N 10.0 10.0 10.0 10.07 BHT 0.1 0.1 0.1 0.18 PHENONIP 0.6 0.6 0.6 0.69 PARSOL 5000 2.0 5.0 2.0 5.010 LANETTE 0 5.0 5.0 5.0 5.011 CUTINAE 24 4.0 4.0 4.0 4.012 氢化PARSOL 8.0 4.0 4.0 4.013 丙二醇 10.0 10.0 10.0 10.014 EDTA 0.1 0.1 0.1 0.115 CARBOPOL 981(1％溶液) 10.0 10.0 10.0 10.016 去矿物质水适量 37.7 34.7 41.7 38.717 乙二醇铵适量调pH 7 7 7 7方法：按照实施例2A的方法。
实施例13B组分％重量比 13Ba 13Bb 13B 13Bd 13Be 13Bf 13Bg 13Bh
c1 PARSOL 1789 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.52 PARSOL 5000 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.03 Arlamol E 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.04 Arlamol HD 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.05 Brij 72 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.06 Brij 721 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.07 Arlacel P135 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.58 Lanette 0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.09 硬脂酸 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.510 Silbione 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0
油70047 V 2011 BHT 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.112 Phenonip 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.613 氢化PARSOL或 8.0 4.013 对-甲氧基肉桂酸 8.0 4.0
三乙醇胺盐13 对-甲氧基肉桂酸 8.0 4.0
单乙醇胺盐13 对-甲氧基肉桂酸 8.0 4.0
钾盐14 Keltrol 1％溶液 12.0 12.0 12.0 12.0 12.0 12.0 12.0 12.0
浓度15 丙二醇 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.016 UmordantP 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.017 去离子水 100 100 100 100 100 100 100 100方法：按照实施例2B的方法。
实施例13C
组分％重量比 13Ca 13C 13Cc 13C 13Ce 13Cf 13C 13C
b d g h1 PARSOL 1789 2.5 2.5 2.5 2.5 2.5 2.5 2.5 2.52 PARSOL 5000 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.03 Arlamol E 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.04 Arlamol HD 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.05 Brij 72 3.0 3.0 3.0 3.0 3.0 3.0 3.0 3.06 Brij 721 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.07 Arlacel P135 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.58 Lanette 0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.09 硬脂酸 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.510 Silbione油70047V20 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.011 BHT 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.112 Phenonip 0.6 0.6 0.6 0.6 0.6 0.6 0.6 0.613 氢化PARSOL或对-甲氧 8.0 4.0
基肉桂酸二乙醇胺盐13 对-甲氧基肉桂酸钾盐 8.0 4.013 对-甲氧基肉桂酸单乙醇 8.0 4.0
胺盐13 对-甲氧基肉桂酸三乙醇 8.0 4.0
胺盐14 Keltrol 1％溶液浓度 12.0 12.0 12.0 12.0 12.0 12.0 12.0 12.015 丙二醇 4.0 4.0 4.0 4.0 4.0 4.0 4.0 4.016 UmordantP 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.017 去离子水 100 100 100 100 100 100 100 100方法：按照实施例2B的方法。
实施例14
使用合适的氙灯作为太阳光刺激器，通过对不同的UV-A滤光剂、UV-B和稳定剂进行严格的平行实验，很容易测得UV-A滤光物质的预期稳定作用。将被测防晒剂涂敷在玻璃板上，照射试样的标准制剂。照射之后，将此盘浸入适宜的溶剂(如乙醇)并用HPLC分析。稳定作用与相同区域照射前后的差别直接相关。
下表Ⅰ-Ⅲ所示的是经10MED单元照射之后的稳定作用，以吸光度的比来表征，相对于未照射试样在max下的吸光度为100％。％:％残留PARSOL 1789
表Ⅰ对照
实施例号 ％ 实施例号 ％ 实施例号 ％
1Aa 46 1Ba 38 1Ca 18
1Ab 48 1Bb 30 1Cb 30
1Ac 54 1Bc 18 1Cc 32
1Ad 60 1Bd 49 1Cd 34
1Ae 68 1Be 45 1Ce 36
1Af 69 1Bf 28 1Cf 43
表Ⅱ氰双苯丙烯酸辛酯作稳定剂实施例号％ 实施例号％ 实施例号％ 实施例号％2Aa 83 3Aa 85 4a 84 8Aa 772Ab 86 3Ab 92 4b 87 8Ab 802Ac 84 3Ac 83 5a 58 8Ac 762Ad 88 3Ad 90 5b 61 8Ad 792Ba 58 3Ba 87 5c 71 8Ae 752Bb 63 3Bb 91 5d 58 8Af 722Bc 70 3Bc 89 6a 782Bd 73 3Bd 86 6b 81 8Ba 69
7a 74 8Bb 55
7b 73 8Bb 58
7c 76 8Bc 68
7d 72 8Bd 59
8Bf 51
8Bg 75
8Bh 69
表Ⅲ PARSOL 5000作稳定剂实施例号 ％ 实施例号 ％9Aa 85 13Aa 809Ab 86 13Ab 839Ba 60 13Ac 819Bb 71 13Ad 8610Aa 86 13Ba 5010Ab 86 13Bb 6210Ba 80 13Bc 6310Bb 89 13Bd 6510Ca 78 13Be 5510Cb 87 13Bf 5110Cc 79 13Bg 6510Cd 84 13Bh 6511a 50 13Ca 5211b 57 13Cb 6212a 70 13Cc 7912b 74 13Cd 78
13Ce 57
13Cf 51
13Cg 62
13Ch 51
Claims (12)
1．光稳定性美容防晒组合物，其中包括至少一个脂相和
a)约0.5-5％重量比的二苯甲酰甲烷衍生物，优选0.5-3％重量比；
b)约0.5-12％重量比的3,3-二苯基丙烯酸酯衍生物或亚苄基樟脑衍生物，优选0.5-10％重量比；和
c)约1-15％重量比的水溶性对-甲氧基肉桂酸盐衍生物，优选1-10％重量比。
2．根据权利要求1所述的防晒组合物，其中二苯甲酰甲烷衍生物是4-叔-丁基-4′-甲氧基二苯甲酰甲烷。
3．根据权利要求1所述的防晒组合物，其中水溶性对-甲氧基肉桂酸盐衍生物是对-甲氧基肉桂酸单乙醇胺盐、对-甲氧基肉桂酸二乙醇胺盐或对-甲氧基肉桂酸三乙醇胺盐。
4．根据权利要求1所述的防晒组合物，其中亚苄基樟脑衍生物是对-甲基亚苄基樟脑和3,3-二苯基丙烯酸酯衍生物是2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯。
5．根据权利要求1-4中任何一项所述的防晒组合物，包括
a)约0.5-5％重量比的4-叔-丁基-4′-甲氧基二苯甲酰甲烷；
b)约0.5-12％重量比的2-乙基己基-2-氰基-3,3-二苯基丙烯酸酯；
c)约1-15％重量比的对-甲氧基肉桂酸单乙醇胺、对-甲氧基肉桂酸二乙醇胺或对-甲氧基肉桂酸三乙醇胺盐。
6．根据权利要求1-4中任何一项所述的防晒组合物，包括
a)约0.5-5％重量比的4-叔-丁基-4′-甲氧基二苯甲酰甲烷；
b)约0.5-12％重量比的对-甲基亚苄基樟脑；
c)约1-15％重量比的对-甲氧基肉桂酸单乙醇胺、对-甲氧基肉桂酸二乙醇胺或对-甲氧基肉桂酸三乙醇胺盐。
7．根据权利要求1-5中任何一项所述的防晒组合物，其中3,3-二苯基丙烯酸酯衍生物与二苯甲酰甲烷衍生物的摩尔比小于0.8。
8．根据权利要求1-6中任何一项所述的防晒组合物，其中对-甲基亚苄基樟脑与二苯甲酰甲烷衍生物的重量比小于3。
9．根据权利要求1-8中任何一项所述的防晒组合物，其特征在于还包含普通的UN-A和/或UV-B滤光剂。
10．根据权利要求1-9中任何一项所述的防晒组合物，呈油、乳液、膏霜、乳剂、凝胶、固体棒剂、气溶胶、喷雾剂、泡沫、粉剂、香波、头发调理剂、敷剂或粉底的形式。
11．水溶性对-甲氧基肉桂酸盐在二苯甲酰甲烷衍生物作为UV-A防晒剂和3,3-二苯基丙烯酸酯衍生物或亚苄基樟脑衍生物作为稳定剂的美容防晒组合物中用作UV-B滤光剂的用途。
12．保护人体表皮或头发免受波长范围290-400nmUV线晒伤的方法，其特征在于将含有有效量的权利要求1-10定义的美容防晒组合物用于皮肤或头发。
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| EP97121090.1 | 1997-12-01 | ||
| EP97121090 | 1997-12-01 |
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| JP (1) | JPH11228374A (zh) |
| KR (1) | KR19990062649A (zh) |
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| AU (1) | AU745721B2 (zh) |
| BR (1) | BR9805050A (zh) |
| CA (1) | CA2254585A1 (zh) |
| ID (1) | ID21391A (zh) |
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| CN102458354A (zh) * | 2009-04-15 | 2012-05-16 | 荷兰联合利华有限公司 | 包含用带有大于70%长链烷基的共聚物结构化的硅油的组合物 |
| CN102781403A (zh) * | 2010-02-03 | 2012-11-14 | 荷兰联合利华有限公司 | 耐光遮光组合物 |
| CN102946848A (zh) * | 2010-06-17 | 2013-02-27 | 银河界面活性剂股份有限公司 | 含有肉桂酰氨基烷基胺的2-羟基磺基甜菜碱的广谱防晒组合物 |
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| BRPI0714634B8 (pt) * | 2006-08-24 | 2016-03-29 | Unilever Nv | composição cosmética fotoestável. |
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| WO2010020668A1 (en) * | 2008-08-22 | 2010-02-25 | Unilever Nv | A cosmetic composition |
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- 1998-11-27 CA CA002254585A patent/CA2254585A1/en not_active Abandoned
- 1998-11-27 NO NO19985564A patent/NO312396B1/no unknown
- 1998-11-30 KR KR1019980051903A patent/KR19990062649A/ko not_active Application Discontinuation
- 1998-11-30 TW TW087119778A patent/TW503111B/zh not_active IP Right Cessation
- 1998-11-30 BR BR9805050A patent/BR9805050A/pt not_active IP Right Cessation
- 1998-11-30 MX MX9810042A patent/MX211093B/es not_active IP Right Cessation
- 1998-11-30 JP JP10338823A patent/JPH11228374A/ja active Pending
- 1998-12-01 CN CNB981261655A patent/CN1154472C/zh not_active Expired - Fee Related
- 1998-12-01 ID IDP981567A patent/ID21391A/id unknown
- 1998-12-01 AU AU95167/98A patent/AU745721B2/en not_active Ceased
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102458354A (zh) * | 2009-04-15 | 2012-05-16 | 荷兰联合利华有限公司 | 包含用带有大于70%长链烷基的共聚物结构化的硅油的组合物 |
| CN102458354B (zh) * | 2009-04-15 | 2014-09-17 | 荷兰联合利华有限公司 | 包含用带有大于70%长链烷基的共聚物结构化的硅油的组合物 |
| CN102781403A (zh) * | 2010-02-03 | 2012-11-14 | 荷兰联合利华有限公司 | 耐光遮光组合物 |
| CN102781403B (zh) * | 2010-02-03 | 2016-11-23 | 荷兰联合利华有限公司 | 耐光遮光组合物 |
| CN102946848A (zh) * | 2010-06-17 | 2013-02-27 | 银河界面活性剂股份有限公司 | 含有肉桂酰氨基烷基胺的2-羟基磺基甜菜碱的广谱防晒组合物 |
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| Publication number | Publication date |
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| NO985564D0 (no) | 1998-11-27 |
| NO312396B1 (no) | 2002-05-06 |
| NO985564L (no) | 1999-06-02 |
| AU9516798A (en) | 1999-06-17 |
| ID21391A (id) | 1999-06-03 |
| KR19990062649A (ko) | 1999-07-26 |
| US5985251A (en) | 1999-11-16 |
| CA2254585A1 (en) | 1999-06-01 |
| JPH11228374A (ja) | 1999-08-24 |
| MX9810042A (es) | 1999-10-31 |
| MX211093B (es) | 2002-10-29 |
| AU745721B2 (en) | 2002-03-28 |
| BR9805050A (pt) | 2000-03-21 |
| CN1154472C (zh) | 2004-06-23 |
| TW503111B (en) | 2002-09-21 |
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