CN1211443A - Nutrient concurrently used as medicated diet and cosmetics for preventing and curing hypersensitive stain, senility and obesity and its manufacture method - Google Patents

Abstract

A nutrient used to prepare edible cosmetics, nutritive food, health-care food, medicine, food, beverage and flavourings is prepared from composite oil of linoleic acid, composite oil of lenolenic acid, compound vitamines, compound trace elements and composite nucleotides, and serves to prevent and cure skin hypersensitivities such as dermatitis, skin rash, prickly heat, alopecia and pigmented spots, obesity and cardiovascular and cerebrovascular diseases.

Description

Prevent and treat the medicine food cosmetic dual-purpose nutrient and the manufacture method of irritated mottle senility and obesity

The present invention relates to nutrient and method field of manufacturing.

Disclose the old and feeble secret of delaying skin (hair is the extension of skin organ), the appearance of remaining youthful forever and health-physical fitness, the people all thirsts for through the ages.For example the history of the cosmetics ancient Egyptian that can demand before more than 4000 year does eye shadow with rouge and malachite powder, the Cleopatra Ao Paitela that is called as the most beautiful girl in the world, make the beauty treatment cosmetics with olive oil, China women's cosmetics use Shi Yeke traces back to the period in Spring and Autumn and Warring States's epoch before more than 2000 year, and the European just brings into use cosmetics after 18th century.Cosmetics no longer are woman's patents now, and the man has also begun to pay attention to and add this market.

Only thick 2 millimeter of skin deserve to be called " shallow " really, but the organ of human body maximum and the natural cover for defense are the windows of viscera disease, and the traditional Chinese medical science " is hoped, hears, asks, cut " first place that prestige is come the method for diagnosing a disease and proved its importance.Current people the eager desire of delaying decrepitude of skin, to the strong pursuit of desirable skin beauty health-care product and require the strong desire of the panoramic dermatosis of radical cure and a feast for the eyes cosmetics that arise at the historic moment between the generation phychology not only liking but also be afraid of, what like is that the skin care science is in continuous development, what be afraid of is to mix the genuine with the fictitious, uncertain therapeutic efficacy is cut, even produces various serious toxic and side effects.People's this ambivalence and the problem that produces of cosmetics need be such as multi-disciplinary joint efforts and breakthroughs such as skin biology, biochemistry, threpsologys now, make further progress and solve, this will promote the production and consumption of cosmetics undoubtedly again, and provide scientific basis for people correctly select aesthetic health care nutriment such as cosmetics.Therefore, the skin scientific research is an important frontier branch of science and system engineering, is worth further investigation, and its theory and application prospect are very wide.

Yet just skin science present Research be it seems at present, can say still to rest on the primary stage so far have many eternal unsolved mysteries to remain to be untied, and has many can the wait for the research topic that the mankind benefit to explore.Document, the monograph data of aspects such as relevant both at home and abroad skin biology are not only few but also disperse, and increase the difficulty of innovation research, also make lots of manufacturers and consumer face the outstanding achievement worthy of the name and the critical shortage of commodity in this respect.That is to say that skin does not occupy due status on its scientific research history, advocating the modern times of liking to be beautiful, should strengthen and quicken the scientific research and the achievement Application and Development of this respect.

Take a broad view of all kinds of cosmetics on the market, be broadly divided into by its function and adjust skin basic cosmetics that makes it to lubricate and the cosmetics that make the skin beauty.A lot of consumers blindly use cosmetics, ignorance can exempt the basic cosmetics that skin is subjected to environmental stimuli for beauty treatment, as scientific research personnel and manufacturer, should consider the two unification, make consumer dual benefited, have also expanded self potential market.Owing to thinking natural component by mistake, consumers in general do not have the carcinogenic doubtful point that waits of food additive, so natural product comparatively consumer is accepted, cosmetics such as beauty and skin care hair care are no exception, have only natural component can guarantee that just pure safe viewpoint in fact is wrong although think, for example may contain Toxic matter, raw material quality equally can be different different because of region, season etc., problem such as incompatible with other compositions in operational restriction of production technology and the preparation, but Producer finally still has to yield to the requirement of consumer, competitively produces so-called natural cosmetics.; simple natural materials can not satisfy the various main nutritional needs of skin; and some compositions are not clear in the plant extraction liquid; effect between the heterogeneity and interact not necessarily complementaryly, the compound prescription that different plant extraction liquids are formed may produce incompatible, and quality is also more difficult stable; maybe can't guarantee comfortable, non-stimulated, nothing allergy; particularly anaphylaxis is the primary safety problem that cosmetics should be considered, because a lot of natural component itself is exactly an anaphylactogen.A lot of natural prodcuts be difficult to satisfy simultaneously four big characteristics that cosmetics must have be effect, comfortable, non-stimulated, do not have allergy, ideal cosmetics also should have the control skin allergy, as dermatitis and some other common disease or functions such as defective such as mottle, acne of very paying close attention to for consumer again, also should have the Skin Cell of raising vigor simultaneously, critical functions such as opposing senescence process.In addition, existing cosmetics nearly all are single externals, and skin is difficult to absorb and utilize the macromole nutrient substance, even there is a small amount of absorption also only to act on top layer skin, can't penetrate deep layer, macromole itself easily causes allergy again, and having ignored for oral administration is micromolecule skin nutrition and human body by digestive system decomposition macromole, and the important channel of eliminating its this skin care of anaphylaxis, cosmetics for external use also might cause potential safety hazard because of eating by mistake to child.Have, fat removing has a strong impact on physical and mental health, also follows superfluous skin and flesh, has a strong impact on skin fitness again.

Purpose of the present invention is exactly that the scientific and technological principle of its foundation is as follows for the deficiency that solves prior art provides a kind of medicine food cosmetic dual-purpose nutrient and manufacture method of preventing and treating irritated mottle senility and obesity:

Essential fatty acid EFA (Essential Fat Acid) comprises linoleic acid family and linolenic acid family, and human body can not synthesize voluntarily, must be unsaturated fatty acid by food supply.Because human body can be from the synthetic successively a series of essential fatty acids of linoleic acid plus linolenic acid, so they are only real essential fatty acid, i.e. parent essential fatty acid.Under the situation that no parent linoleic acid plus linolenic acid exists, can not synthesize any essential fatty acid in the body, can only from food, obtain.The 4-5% that EFA only need account for total amount of heat can reach the metabolic process that suitable heat energy physiology tired, guaranteed that skin, retina, brain and nervous system normal configuration and function, normal pulmonary function and all energy rely on.It is all low that EFA lacks the EFA content that causes brain, skin and retina cell phospholipid to reach wherein, the formation of myelin and the growth of brain are damaged greatly, weight and generation acataleptic as direct reduction brain, particularly outstanding heavy to pregnant, wet nurse and embryo, infant infringement, last 3 months of gestation to be born back 18 months be the human brain ramp phase, therefore pregnant, wet nurse EFA nutrition is on the low side and premature labor, low birthweight infant have the bigger harm of brain and nervous system disorders.EFA is the important composition of phospholipid, and phospholipid is again biomembranous Main Ingredients and Appearance, epithelial cell and fibroblast dysmaturity when EFA lacks, and the fatty acid structure of skin tissue cell membrane lipid changes, and permeability increases, and easily by microbial infection, and produces irritated.For example the low milk side of baby children feed linoleic acid is when staphy lococcus infection is popular, easily seriously infected; EFA lacks common, multiple dermatosis susceptible diseases such as also can making pustule disease, miliaria, dermatitis and is difficult to healing, and scald waits the skin injury healing time to prolong; EFA deficiency or dysbolismus make the synthetic minimizing of prostaglandin, because some metabolites of EFA such as arachidonic acid and two all type acid and gamma-linolenics (linoleic acid metabolism generation) and 20 carbon 5 alkene acids (linolenic acid metabolism generation) all are the predecessors of prostaglandin, one of numerous functions of prostaglandin are the mitogenetic and differentiation of management normal epithelium cell, deficiency can cause the skin defense function undermined, other function such as blood pressure regulation and cholesterol are synthetic, inflammation such as control such as allergy take place and promote cell proliferation etc., and are all closely related with skin health; EFA lack also can be when causing prostaglandin to lack zinc deficiency because its assists zinc to absorb, eczema sample pathological changes around eczema sample pathological changes such as the mouth appears, cystic fibrosis becomes and gallbladder enucleation patient also can cause because of fat absorption is bad.The minimizing of EFA and prostaglandin, can suppress the phosphorylation of happiness oxygen biology and the metabolic process that all energy rely on, depress the formation of blood red cell membrane HbO2 Oxyhemoglobin is seriously disturbed as normal lung oxygen, oxygenate and Cellular respiration in the systemic cell are suppressed, the arterial oxygen pressure drop is low, the energy level of supply reduces, and health condition worsens; The FEA also interior satisfied fatty acid of control agent makes it unlikely too much, thereby mortality rates such as the heart, cerebrovascular system disease such as atherosclerosis that reduction is caused by too much satisfied fatty acid, obesity, fatty liver are high, are called human first killer's serious ciril disease.Because EFA is with respect to the demand of fat and total amount of heat 4-5% (minimum 1%) only, amount not quite but very easily lacks for example meets anoxia, stress state or generation infectious disease etc. all significantly increase the consumption of EFA, show condition of illness rapidly, and above-mentioned many critical functions are arranged, during again because of EFA amount in the body and the increase of other unsaturated fatty acids, vitamin E metabolism and consumption in vivo also strengthens, vitamin E can improve linoleic physiological function again, it is very similar when the corresponding pathological changes that body produces during shortage lacks to EFA, vitamin E also can quicken the healing speed of EFA shortage etc., so in recent years more and more scholars generally acknowledge EFA be vitamin and EFA come vitamin E after claim vitaminF, represent that also EFA is the fatty vitamin.Linolenic acid and effect are worth further pointing out among the EFA: clinical medicine proves, the linoleic acid that people ingest generally is converted into gamma-Linolenic acid in vivo earlier, it is prostaglandin that this reaction needs with being converted into two all type gamma-Linolenic acids again after δ-the 6-desaturase is participated in, and it is higher 170 times than linoleic acid that gamma-Linolenic acid reduces the effect of plasma cholesterol; Numerous disease such as diabetes, senile disease, viral infection and specific reaction disorder etc., the capital is disturbed the function of δ-6-D acid and is hindered the generation of gamma-Linolenic acid, even have competent linoleic acid also can cause the prostaglandin hyposecretion this moment, body's immunity regulating system and metabolism further weaken; Alpha-linolenic acid in human body through desaturation and carbochain prolongation effect, generating docosahexenoic acid is that DHA and eicosapentaenoic acid are metabolism materials such as EPA, DHA and EPA tool hypermnesis and vision effect, because they are main components of cephalin and retina phospholipid, can protect the 26S Proteasome Structure and Function of brain and central nervous system cell well, by laudatory title is NAOHUANGJIN, is the effective constituent that mainly contains of expensive bathypelagic fish oil; Alpha-linolenic acid is also had a blood fat reducing, antithrombotic and is formed and the control diseases of cardiovascular and cerebrovascular systems, anticancer diffusion and effect such as anticancer.In addition, another key property of EFA can be smeared and be absorbed rapidly exactly and bring into play various effects by skin, does not only have any stimulation, prevents and treats serial dermatosis such as dermatitis again, and, also can only cure and to take effect rapidly and thoroughly healing by EFA because of EFA lacks the disease that causes.

Vitamin C is participated in the formation of collagen, make injured neural rehabilitation, keep diseases such as skin elasticity and vigor and control neurodermatitis, vitamin C impels the tyrosine oxidation, reducing melanin generates, be beneficial to the removal skin splash, but also cholesterol reducing and triglyceride are prevented and treated arteriosclerosis, increase interferon and generate antiviral and infection such as staphylococcus aureus etc.Vitamin E can be strengthened also can quickening to remove antigen outside the EFA effect as described above, reduces anaphylaxis such as erythra, mottle etc., improves whole body to effects such as the resistance, the protection vitamin A that infect are not oxidized.Vitamin A can reduce collagen protein degraded and crease-resistant, delay or reverse skin aging, keep epithelial cell integrity and cell membrane stability, opposing is irritated and infect, lack to cause that skin delayed hypersensitivity, Keratoderma pimple, dry coarse desquamation, pigmentation, hair simply come off etc.Vitamin B ₅Be the bioactive pantothenic acid form of tool, can reduce the time of wound healing 40%, glabrous skin and hair, be absorbed fast and the skin nutrition hair, regulate and maintenance moisture, strengthen pliability, opposing machinery and chemical damage improve humoral immunity etc. as washing and dressing and scalding, have hair dyed.Vitamin B ₁, B ₂And B ₆Have the oiliness that reduces oily hair and skin, prevent and treat seborrheic dermatitis, edema and pigmentation improve functions such as infecting resistance.The trace element zinc deficiency makes that collagen is synthetic to produce that obstacle, dermatitis, baby's dermatitis, alopecia, cell and humoral immunization descend as the killing tumor cells ability reduces, in the body surplus in the of 100 the enzyme of kind and immunity, energy and nucleic acid metabolism the zinc participation is all arranged or does constituent.Trace element-selenium makes the peroxide accelerated decomposition, and vitamin E prevents the generation of unsaturated fatty acids acid peroxide, though the two mechanism of action is different, but the identical production concentration that promptly reduces the generation of body peroxide or generate thus of the biochemical effect of antioxidative, selenium has resistant function to some carcinogen, and this is to very easily directly carcinogenic skin of contact and cosmetics are particularly important.Inosine is uniquely can replace ATP, be adenosine triphosphate (can not directly enter cell membrane) and CoA be the direct permeate through cell membranes of coenzyme A enter human body cell with remove the purine class nucleotide source of cell low-energy state, make the cell that is under the mental retardation anaerobic condition particularly cosmetics directly the Skin Cell vigor of service return to normal level rapidly; Thymidine is a miazines nucleotide, inosine and thymidine have the various purine that can change into nucleic acid respectively and pyrimidine nucleotide simultaneously and through the synthetic complete nucleic acid of nucleic acid synthesis mechanism to improve cell viability, from solving an anti-ageing difficult problem in essence, and thymidine has replacement VB ₁₂Keep the cell proper splitting with folic acid, assist active methyl to synthesize critical functions such as reaching enhance immunity, these are very important to protection skin and body cell vigor.

The medicine food cosmetic dual-purpose nutrient of the irritated mottle senility and obesity of control provided by the invention is with refining turnip oil, Semen Lepidii Semen Desurainiae oil, Semen Maydis oil, safflower oil, sunflower seed oil, Semen Lini oil, vitamin B ₁, B ₂, B ₅, B ₆A, C, E, sodium selenite, zinc oxide, inosine, or corresponding inosinic acid and sodium salt and thymidine or corresponding thymidylic acid and sodium salt make, and its raw material materials (deduction water content) are by weight: turnip oil 1-20 part (containing linoleic acid 50%), safflower oil (safflower oil) 1-20 part (containing linoleic acid 70%), Semen Maydis oil 1-20 part (containing linoleic acid 50%), sunflower seed oil 1-20 part (containing linoleic acid 50%), Semen Lepidii Semen Desurainiae oil 1-20 part (contain linolenic acid 48% and 38% and be alpha-linolenic acid), primrose oil 1-20 part (containing linoleic acid 86%), Semen Lini oil 1-20 part (containing linolenic acid 43%), inosine or inosinic acid or inosinic acid sodium salt 1-3.5 part, thymidine or thymidylic acid or thymidylic acid sodium salt 1-3.2 part, VA 0.001-0.01 part, VC 1-2 part, VE 1-2 part, VB ₁0.1-0.3 part, VB ₂0.1-0.3 part, VB ₅0.1-0.3 part, VB ₆0.1-0.3 part, sodium selenite 0.001-0.01 part, zinc oxide 0.01-0.2 part

The derivant of the identical physiological action of the also available GB2760-1996 approval of the various vitamin in the above-mentioned prescription and selenium, zinc substitutes or share, and consumption is by the conversion of tiring of active substance and physiology.

The foundation of prescription is supplemented as follows:

Be tested and appraised to 1998 from national natural science fund subsidy project in 1988 " research and the utilization of new oilseed plant Orychophragmus violaceus " and confirm that turnip oil is the extremely cheap and outstanding essential fatty acid source that contains linoleic acid 49%; 1985 colleges and universities of State Education Commission fund assistance problem " development and use of Cruciferae oilseed plant genetic resources " put special scientific research fund approval with the doctor of colleges and universities of State Education Commission subject in 1992 and subsidize problem and " use relevant Plant Biotechnology; " extremely newfound special oil Study on plants; be tested and appraised in 1998, most important achievement is descurainia sophia (l.) webb ex prantl variety source and oil value.Semen Lepidii Semen Desurainiae oil contains alpha-linolenic acid and reaches 38%, be converted into expensive EPA and DHA in vivo, and self is equally cheap and easy to get with turnip oil, 5 pieces of paper income world authoritative journal SCI are arranged, and scientific research level reaches rank first, is latest scientific research, of fine qualities, nutrition and prevention effect are good, and it contains linoleic acid (18%) and linolenic acid simultaneously, are perfect form essential fatty acid sources.

The medicine food cosmetic dual-purpose nutrient and the manufacture method of preventing and treating irritated mottle senility and obesity are:

1. linoleic acid source compound oil and manufacture method are:

In sterilizing room, press turnip oil 1-20 part, Semen Maydis oil 1-20 part, safflower oil 1-20 part, sunflower seed oil 1-20 from, primrose oil 1-20 part appoint get a kind of several or all take and do the linoleic acid source, join in the stainless steel equipment of belt stirrer, stirred 5-10 minute the fully airtight use of mixing with 20-60 rev/min rotating speed.

2. Caulis et Folium Lini acid source compound oil and manufacture method are:

In sterilizing room, press Semen Lepidii Semen Desurainiae oil 1-20 part, Semen Lini oil 1-20 part is appointed and is got a kind of or take and make Caulis et Folium Lini acid source, is added in the stainless steel equipment of belt stirrer, stirs 5-10 minute with 20-60 rev/min rotating speed, and fully mixing is airtight standby.

3. compound vitamin and manufacture method are:

Press VA 0.001-0.01, VC 1-2 part, VE 1-2 part, VB in sterilizing room ₁0.1-0.3 part, VB ₂0.1-0.3 part, VB ₅0.1-0.3 part, VB ₆0.1-0.3 part take by weighing, in the rustless steel mortar porphyrize 2-4 minute, fully grind well and be paste, airtight preservation is standby.

4. compound microelement and manufacture method are:

Aseptic indoor get sodium selenite 0.001-0.01 part, zinc oxide 0.01-0.2 part are arranged, grind in the body to grind at rustless steel and be the smalls shape in 3-5 minute, airtight preservation is standby.

5. compound nucleotide and manufacture method are:

In sterilizing room, to appoint by inosine, inosinic acid or sodium inosinate 1-3.5 part and to get a kind ofly, thymidine, thymidylic acid or thymidylic acid sodium 1-3.2 part are appointed and got a kind ofly, grind 2-3 minute abundant mixing in the rustless steel mortar, and is airtight standby.

6. prevent and treat the preparation of the medicine food cosmetic dual-purpose nutrient of irritated mottle senility and obesity:

In sterilizing room, the formula proportion weighing is pressed in linoleic acid source and Caulis et Folium Lini acid source compound oil, compound vitamin, compound microelement and compound nucleotide, in having the stainless steel equipment of agitator, stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing product.

Prevent and treat the medicine food cosmetic dual-purpose nutrient product of irritated mottle senility and obesity, be limited to example more than the main nutrient composition that contains in per 100 grams (by the calculating of over dry material) and be:

Linoleic acid source compound oil (turnip oil, Semen Maydis oil, safflower oil, sunflower seed oil, primrose oil one or several) 38.46 grams, Caulis et Folium Lini acid source compound oil (Semen Lepidii Semen Desurainiae oil, Semen Lini oil or any) 38.46 grams, compound vitamin 10.00 grams, compound microelement 0.20 gram, compound nucleotide 12.88 grams.

The present invention prevents and treats the purposes of the medicine food cosmetic dual-purpose nutrient product of irritated mottle senility and obesity and produces all kinds of edible cosmetics and the host as Cosmetic Manufacture except that can be used as, but also production varieties of food items.Baby-children product particularly, beverage, flavoring agent, health product, the host that these products are produced in medicine and conduct, consumption all can add by GMP (ordinary production needs) standard, as various beverages, sweet food, salty food, soup stock, animal and plant Sexual health promotion edible blend oil, fragrant, peppery, numb, hot, salty, sweet, bright, sour, flavoring agent, skin or hair care cream, skin or hair care liquid, medicine and health product such as glue Liang, tablet, oral liquid and cream, electuary, nutritional solution and cream, electuary etc.

Medicine food cosmetic dual-purpose nutrient and manufacture method that the present invention prevents and treats irritated mottle senility and obesity have following advantage:

1. the present invention is according to traditional Chinese medical science inner disease outer treat, the anti-double total inventive concept that principle and consumption habit are considered as a whole of controlling of holding concurrently, adopting the composite natral composition to keep product is natural product, overcome the thin shortcoming of single natural goods effect single force, various nutritional labelings, content, effect and the relation of influencing each other are clear simultaneously, both can be qualitative, and again can be quantitative, raw material quality is stable, and it is in line with international standards to be beneficial to product; It is not clear to have overcome composite parts in the primary plant extract and content and interaction relationship, is difficult for qualitative and quantitative analysis, significant drawback such as raw materials quality and source de-stabilising effect production and steady quality.

2. all the components all meets country edible or food additive GB2760-1996 and FDA (FDA), The World Health Organization (WHO), FAO's internal authority organizational standards such as (FAO) and about the definition of natural component promptly from naturally occurring material or with the synthetic material identical of manual method with natural materials, as take from the dimension C of plant and the dimension C of synthetic all is considered as natural materials, this has paved road for product and production and marketing merchant open up wide domestic and international market, has solved the suitability for industrialized production raw material sources that adapt to it and has ensured a difficult problem.

3. the high linoleic acid oil sources is extensive relatively in the two class essential fatty acid, but super quality and competitive price the high linolenic oil sources then relatively difficulty seek, particularly the alpha-linolenic acid source can be converted into expensive EPA and DHA in vivo, the present invention is with linoleic acid and linolenic acid and usefulness, not only transferred the interior normal linoleic acid of body and be converted into the function of acid and gamma-linolenic to save Caulis et Folium Lini acid source, the conversion disorder of also having prevented and treated because of aforementioned various common disease settings causes lacking the serial complication that causes because of linolenic acid, thereby make product efficacy comprehensive, with low cost.

4. the compound vitamin of the present invention design is the easiest shortage of human body in the numerous kinds of vitamin, and has complementary advantages, do not have antagonism mutually, makes the product overall efficacy extend greatly and strengthen.This four biostearin is jointly used, anti-oxidation efficacy is a synergism, to preventing and treating multiple pathological changes of other organs of all kinds of dermatitis and body and courses of infection, anti-multiple anaphylaxis, sound damaged skin and neurocyte structure and the function of repairing, raising animal economy immunity etc. are evident in efficacy.

5. the compound microelement of the present invention's design is that the numerous crowds in vast region very easily lack, they not only work in coordination with and strengthen the effect of aforementioned each biostearin, selenium is also worked in coordination with enhance immunity with dimension E, dimension C and is improved its physiology and tire, and participates in or the sharp in vivo vigor of hundreds of enzyme; Zinc is prevented and treated dermatitis and very itching of causing thus, alopecia, short collagen is synthetic, and the short nucleic acid of collaborative vitamin B group is synthetic to improve cell viability, delaying decrepitude of skin etc.

6. the compound nucleotide of the present invention design, purine and pyrimidine are complete, all are single micromolecule, very permeable is crossed skin and is directly absorbed, express life-information through changing the complete human body nucleic acid chains of one-tenth capable of being combined, strengthen cell viability, what at first be benefited is Skin Cell, cell hypoxia be can remove immediately and energy and fatigue state lacked, effectively prevent and treat even reverse skin and body aging, and inosine is cheap and easy to get, and effect is got instant result, and this is not only expensive but also can not be difficult to accomplish by ATP and the CoA that external directly enters Skin Cell; Though the breast pyrimidine is than the inosine costliness, it also can replace VB except that can directly doing the nucleotide application ₁₂Wait effect with these two kinds of vitamin of folic acid in that aforesaid promotion nucleic acid is synthetic, having overcome folic acid needs the just stable and cosmetics of alkaline environment must acid (PH5.5-6.0) just to meet the shortcoming of skin biochemistry environment, VB ₁₂Though acid stable, molecular weight are too big, skin is difficult for absorbing, and absorbs through digestive tract, needs the glycoprotein combination with excretory a kind of the crying of stomachus pyloricus mucosa " internal factor ", could see through intestinal wall to be absorbed, and some people lacks internal factor and causes VB ₁₂Lack and oral invalid, can only inject and make troubles with painful.

7. cosmetics should be subacidity and will guarantee that antioxidation is anti-corrupt, the present invention adopt the dimension C adjustment of acidity and with the dimension A, dimension E unites antioxidation, the pure natural component and the effect of product have not only been guaranteed, and having prevented may be to the side effect such as allergy of skin as commonly used 0.01% antiseptic triethanolamine and 2-bromo-2-nitro-1 because of adding conventional antioxidation and antiseptic, the easy oxidation of ammediol generates nitrosamine and causes irritated and carcinogenic, they can stop the formation of nitrosamine, VA also can reduce the degraded of collagen protein enzymatic activity and collagen protein, can obviously reduce the true property of wrinkle, particularly person in middle and old age intractable wrinkle (50-70 year) in 5 weeks.

8. all the components external is for oral administration because the present invention fills a prescription all easily absorbs, so the production edible cosmetics becomes a reality, has not only improved safety, and can bring into play the function of two different absorption approach simultaneously, receives double effect and instant effect.

9. the present invention's not only effect complementation of all the components of filling a prescription, nonirritant, but also initiative is prevented and treated multiple diseases such as skin that various reasons causes and body aging, allergy, mottle, and shorten treatment time greatly, internal and external application is held concurrently anti-.

10. the present invention does not contain any hormone, does not only have any hormone side effect, and the VB in the prescription ₆, the various metabolic deficiencies that all jointly estrogen antagonist and other oral contraceptives caused of VC, VA, nucleotide such as tryptophan metabolism defective and side effect significantly consume as the above-mentioned various vitamin that cause because of the clothes contraceptive and the side effect such as go down of the spirit depressing, anemia, the sugared dosis tolerata that cause, this is to the numerous women of child-bearing age, and the health of lactication mother and infant is very important.

11.EFA shortage make that phospholipid is synthetic to be reduced, cholesterol metabolism is also with phospholipid contention EFA, VB ₆, vitamin deficiency such as pantothenic acid also causes lipid metabolism bad, selenium, zinc are the components of plurality of enzymes in the energy metabolism, these factors all seriously cause fat disease, fatty liver diseases, this product tackles fat good recipe beyond doubt, prevents and treats serious diseases such as obesity in beauty and skin care, and without any side effects, dietary restriction determined curative effect not, instant effect and stable lasting, but no overweight people's health-care face-beautifying is strengthened body constitution.

12. it is good effect, allergy comfortable, non-stimulated and that therefore cause that the present invention has four big characteristics of outstanding cosmetics.Allergic contact dermatitis accounts for 80% of cosmetics adverse effect, and easily betides important sight position and more little easy more generations of age such as face, lip, eye, and they just are the altofrequency user of cosmetics, so it is very important to prevent and treat allergy.Formula components of the present invention all is micromolecule and is the natural existence of the easy shortage of human body and the nutrient that directly absorbs with molecular state, immune system can not be encroached on processing as the allosome macromole with it and be caused that immunoreation stimulates and allergy as producing, and every kind of composition is all at producing material hypersensitive and approach, comprise cosmetics in addition 20% adverse effect as mainly by hormone, brightening agent such as mercury salt and hydroquinone, pigment and unabsorbable mineral oil, self components such as spice cause allergy, pigmentation, heavy metal poisoning and outside sensitizing agent such as pollen, dust, pathogenic bacterias etc. are adsorbed in by cosmetics and cause allergic reaction on the skin and dermatitis that ultraviolet (containing light) causes and pigmentation etc., and jointly control is irritated, dermatosiss such as mottle; They absorb and transform rapidly, and softness is not sticking, and so gloss skin is comfortable; Their absorption rates are high, more than 90%, and instant effect, general one course of treatment of 5-6 day, 3-5 days take effect, and how to disappear 7-10 days dermatitis, and 2-3 week cures, and effect is comprehensively complementary, is that VA, VE surfactant are beneficial to skin absorbs as EFA, so effect is good; Their full nutrition skin, improve cell viability, effectively opposing senescence process and obesity, fat liver and series cause disease, oral administration and externally makes renders a service multiplication, and does not have dose limitation, and scientific and technological content is very high, science and technology is theoretical genuine and believable, the compound basis abundance, academia is generally acknowledged and domestic and international official quality standands is arranged both at home and abroad, meets the various requirement of desirable cosmetics.

13. the control mottle is the cosmetics a great problems, common mottle (pigmentation) is broadly divided into because of Pigmented butterfly spot of hormonal such as gestation, oral contraceptives, the present invention can effectively prevent and treat and be useful and harmless to pregnant, female tire, baby as described above, and prevent because of stop with hydroquinone, mercurial tyrosinase activity (copper is prothetic group) and bleaching exert an influence the hair blackness and in toxic and side effects; The acne black speck can be controlled the short lipid metabolism of sebum secretion and EFA and prevented and treated by vitamin B group; Freckle, chloasma increase melanin because of ultraviolet and liver function are bad and form, and the present invention also gives solution, and particularly nucleic acid is strengthened the hepatocyte vigor, and inducing interferon opposing virus etc. make the initiative prevention effect better, are the action that effects a permanent cure; Senile plaque is that the generation of multiple dermatitis also relates to free radical because of the lipofuscin deposition gradually becomes, and these mottles form roughly as follows:

Free radical causes lipid peroxidation to generate material such as malonaldehyde making protein cross form polymer such as lipofuscin (senile plaque), be the basic feature of cell senescence, be insoluble in water, and difficult eliminating is put and is piled into speckle; Free radical is attacked DNA, and the activation carcinogen suppresses the C-AMP enzyme and makes C-AMP and the change of C-GMP concentration cause cell to lose normal contact inhibition, infinitely divides and induced tumor; Free radical activates collagen protein and hyaluronidase activity and degrade collagen albumen and hyaluronic acid cause skin aging, wrinkle, arthritis, cataract and retina injury etc., ultraviolet radiation causes the reaction of light juxtaposition, be photosensitivity source (hapten), the free radical that produces becomes holoantigen to start tardy allergy with protein binding, the short tyrosine series of the oxygen-derived free radicals that produces oxidation reaction generates melanin and the generation of short lipofuscin and causes their deposition, so free radical is the real murderer of skin aging.The present invention designs multivitamin associating free radical resisting, not only power is powerful, and because of the antioxidation that multiplies each other, reduced consumption, avoid certain vitamin effect of single a large amount of use low and side effect also easily do not arranged comprehensively, can cause endocrine regulation as crossing multidimensional E, also replaced SOD commonly used, Agifutols etc. reach easy oxidation and loss of activity and expensive antioxidant reductase, guarantee the product curative effect and prolong shelf and operating period, also transfer the Skin Cell internal vitality simultaneously and initiatively resist aging, prevent from and alleviate to produce new pigment and deposition etc. as quickening metabolism and getting rid of sedimentary pigment with nucleic acid.

Embodiment:

1. get 20 parts of linoleic acid source compound oils, 20 parts of Caulis et Folium Lini acid source compound oils, 3 parts of compound vitamines, 0.1 part of compound microelement, 6 parts of compound nucleotides, in the rustless steel agitator, fully mix thoroughly, be used to produce medicine for oral administration, as soft gelatin capsule (every 0.5-2 gram), oral liquid or nutritional solution (5ml-10ml/ bottle), add an amount of cyclodextrin curing and be pressed into tablet (0.5-2 gram/grain), or make health food, beverage additive, enriched nutritive is worth, consumption needs by ordinary production, no dose limitation is prevented and treated diseases such as dermatitis, mottle, obesity.

2. get 15 parts of linoleic acid source compound oils, 15 parts of Caulis et Folium Lini acid source compound oils, 4 parts of compound vitamines, 0.2 part of compound microelement, 3 parts of compound nucleotides, in the rustless steel agitator, fully mix thoroughly, be used for the production external and smear medicine and edibility cosmetics treatment the dermatitis particularly scorching and all kinds of expansion skin hair care dews of baby's sekunda, liquid, adding an amount of Powdered sucrose ester solidifies or semi-solid preparation, produce all kinds of paste cosmetics, as facial cream, face cream, lipstick, lip pomade, lip fat, the cream of haircuting, suntan lotion, frost, toothpaste etc.Sucrose fat is nontoxic, and is tasteless, non-stimulated, edible, thus do not influence safety and edibility, and sucrose ester tool hydrophilic and oleophilic bidirectional characteristic, jointly control skin oiliness in appropriate scope with VB6, prevent and treat xerosis cutis or seborrheic dermatitis, improve skin appearance.

3. get 10 parts of linoleic acid source compound oils, 10 parts of Caulis et Folium Lini acid source compound oils, fully miscible with the low EFA edible oil (comprising animal oil) of 80% Semen Allii Tuberosi wet goods, be mixed with edible blend oil, can significantly improve its nutrition, health care, physiology and tire etc. edible and economic worth and promote lipid metabolism, control fatty liver diseases.Edible oil market is extremely wide, and market prospect is infinitely bright.

4. get 5 parts of linoleic acid source compound oils, 5 parts of Caulis et Folium Lini acid source compound oils, 2 parts of compound vitamines, 0.02 part of compound microelement, 6 parts of compound nucleotides (inosine is changed to inosinic acid or guanyl to increase aquatic foods), in the rustless steel agitator, fully mix thoroughly, produce the high-grade nutrient flavoring agent or as additive of flavourings as mixing or share with Sal, monosodium glutamate, various perfume (or spice), suffering, fiber crops, the former material list of peppery, bright seasoning, produce all kinds of high-grade nutrients, increase bright flavoring agent.

Claims (3)

1. a medicine of preventing and treating irritated mottle senility and obesity is eaten cosmetic dual-purpose nutrient, is grouped into by following one-tenth:

Linoleic acid source compound oil 1-20 part

Caulis et Folium Lini acid source compound oil 1-20 part

Compound vitamin 2.4-5.2 part

Compound microelement 0.011-0.21 part

Compound nucleotide 2-6.7 part

Wherein, the linoleic acid compound oil is made up of turnip oil, Semen Maydis oil, safflower oil, Oleum helianthi, primrose oil, and Caulis et Folium Lini acid source compound oil is made up of Semen Lepidii Semen Desurainiae oil, Semen Lini oil, and compound vitamin is by VA, VC, VE, VB ₁, VB ₂, VB ₅, VB ₆Form, compound microelement is made up of sodium selenite, zinc oxide, compound nucleotide is made up of inosine, inosinic acid, inosinic acid sodium salt, thymidine, thymidylic acid, thymidylic acid sodium salt, or the derivant of using the identical physiological action of tool of GB2760-1996 approval substitutes said vitamin and trace element or share, and consumption is by the conversion of tiring of active substance and physiology.

2. the manufacture method of preventing and treating the medicine food cosmetic dual-purpose nutrient of irritated mottle senility and obesity is:

(1) preparation of linoleic acid source compound oil:

In sterilizing room, press turnip oil 1-20 part, Semen Maydis oil 1-20 part, safflower oil 1-20 part, sunflower seed oil 1-20 from, primrose oil 1-20 part appoint get a kind of several or all take and do the linoleic acid source, join in the stainless steel equipment of belt stirrer, stirred 5-10 minute the fully airtight use of mixing with 20-60 rev/min rotating speed;

(2) preparation of Caulis et Folium Lini acid source compound oil:

In sterilizing room, press Semen Lepidii Semen Desurainiae oil 1-20 part, Semen Lini oil 1-20 part is appointed and is got a kind of or take and make Caulis et Folium Lini acid source, is added in the stainless steel equipment of belt stirrer, stirs 5-10 minute with 20-60 rev/min rotating speed, and fully mixing is airtight standby;

(3) preparation of compound vitamin:

Press VA 0.001-0.01, VC1-2 part, VE1-2 part, VB in sterilizing room ₁0.1-0.3 part, VB ₂0.1-0.3 part, VB ₅0.1-0.3 part, VB ₆0.1-0.3 part take by weighing, in the rustless steel mortar porphyrize 2-4 minute, fully grind well and be paste, airtight preservation is standby;

(4) preparation of compound microelement:

Aseptic indoor get sodium selenite 0.001-0.01 part, zinc oxide 0.01-0.2 part are arranged, grind in the body to grind at rustless steel and be the smalls shape in 3-5 minute, airtight preservation is standby;

(5) preparation of compound nucleotide:

In sterilizing room, to appoint by inosine, inosinic acid or sodium inosinate 1-3.5 part and to get a kind ofly, thymidine, thymidylic acid or thymidylic acid sodium 1-3.2 part are appointed and got a kind ofly, grind 2-3 minute abundant mixing in the rustless steel mortar, and is airtight standby;

(6) preparation of the medicine food cosmetic dual-purpose nutrient of the irritated mottle senility and obesity of control:

In sterilizing room, the formula proportion weighing is pressed in linoleic acid source and Caulis et Folium Lini acid source compound oil, compound vitamin, compound microelement and compound nucleotide, in having the stainless steel equipment of agitator, stirred 5-10 minute with 20-40 rev/min rotating speed, fully mixing product;

3. prevent and treat the purposes of the medicine food cosmetic dual-purpose nutrient of irritated mottle senility and obesity, it is characterized in that being used for: produce edible cosmetics, host as Cosmetic Manufacture, as producing food particularly baby-children product, beverage, flavoring agent, health product, medicine and host, consumption needs to use by ordinary production, produce sweet, salty food and beverage, soup stock, of animal or plant nature edible health mixed oil, fragrant, hot, numb, peppery, bright, one-tenth flavoring agent, skin or hair care cream, liquid, dew, toothpaste, capsule, tablet, electuary, oral liquid, cream, nutritional solution, cream.