CN1199632A - Chinese medicine preparation as adjuvant for chemotherapy of tumour and its preparation process - Google Patents
Chinese medicine preparation as adjuvant for chemotherapy of tumour and its preparation process Download PDFInfo
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- CN1199632A CN1199632A CN 98102133 CN98102133A CN1199632A CN 1199632 A CN1199632 A CN 1199632A CN 98102133 CN98102133 CN 98102133 CN 98102133 A CN98102133 A CN 98102133A CN 1199632 A CN1199632 A CN 1199632A
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Abstract
The Chinese medicine preparation is prepared by using Fructus Psoraleae, Codonopsis Pilosulae, tuckahoe, Atractylodis Macrocephalae, privet fruit and red sage as material and through the processes of wind drying, crushing, solvent extraction, decocting, mixing, drying, grinding, sieving, disinfection and capsulizing. It has unique recipe and preparation process, and it can strength body's immunity, improve arrest of bone marrow and digestive tract reaction due to chemotherapy and raise the effect of chemotherapy.
Description
The present invention relates to a kind of medicine of adjuvant for chemotherapy of tumour, specifically is the Chinese patent medicine of feedstock production with the Chinese herbal medicine.The invention still further relates to the preparation method of this medicine.
Tumor is one of commonly encountered diseases of harm humans health.It is about 7,000,000 that at present the world dies from the malignant tumor number every year, the annual about 1,600,000 New Development tumor patients of China, and 105 die ten thousand deaths in this inducement.Be first of various diseases death in the city, and have and increase trend year by year.
The chemotherapy malignant tumor has basically formed a complete theoretical system since the application of nineteen forty-six chlormethine.But because most of chemicals poor selectivity, the physiological function to normal structure and internal organs after the medication has certain destruction, often causes chemotherapy treatment and a series of toxicities such as can not finish.Mainly show as: bone marrow depression; Digestive tract reaction; Immunologic hypofunction etc.
The method curative effect of the various control chemotherapy toxic side effects of modern medicine certainly at present: as blood transfusion, sharp blood liter, hemopoietic growth factor, ondansetron etc.But also there are many problems in these present methods, have inadequate blood source as blood transfusion, and paathogenic factor gets more and more and limits its use in the blood; Hemopoietic growth factor can promote that the leukaemia breeds, and suppress the cytotoxicity chemotherapeutics and bring out the acute leukemia cells apoptosis, and the bone marrow that can not solve chemotherapy damages outward, has dispute so Hemopoietic factor used.Simultaneously, these drug mains will work from single angle, integrally-regulated poor effect; And cost an arm and a leg, clinical use is limited.
The Chinese medicine preparation kind of just existing adjuvant chemotherapy is that principle is selected the medicine prescription mostly with the strengthening the body resistance, and curative effect is sure.Yet, clinical practice shows that many tumor patients itself have the existence of syndrome of blood stasis, after particularly having accepted chemotherapy, obviously increasing and increasing the weight of appears in patient's syndrome of blood stasis due to qi deficiency, show as the appearance of picture of the tongue and the objective disease of traditional Chinese medical science blood stasis, microcosmic detects high blood coagulation state and patient's cellular immune function and active the reduction, and is relevant with transfer with the recurrence of tumor middle and advanced stage.So only exist certain not enough from setting upright angle.
The purpose of this invention is to provide and a kind ofly prevent and treat bone marrow depression behind the chemotherapy of tumors, alleviate digestive tract reaction, enhancing human body immunity power, improve high blood coagulation state, dredge microcirculatory Chinese patent medicine.
Another object of the present invention provides the preparation method of this Chinese medicine preparation.
Solution of the present invention be based on motherland's medical science to chemotherapy of tumors after the understanding and the Therapeutic Principle of toxicity, achieve with reference to modern pharmacological research, from motherland's medical treasure-house, filter out the natural plant of kidney tonifying spleen invigorating, inrigorating qi and promoting blood circulation, by the theory of Chinese medical science prescription, skim the cream off milk, make its performance improve human immunity state, prevent and treat bone marrow depression, reduce digestive tract reaction, improve blood circulation, collaborative chemotherapy improves curative effect, control tumor recurrence and transfer, prolong life cycle, alleviate the effect of life quality.
Medicine of the present invention is made by following component:
Fructus Psoraleae 15-25 part Radix Codonopsis 15-25 part Poria 10-15 part
Rhizoma Atractylodis Macrocephalae 10-15 part Fructus Ligustri Lucidi 10-15 part Radix Salviae Miltiorrhizae 6-15 part
The optimum weight proportioning of medicine of the present invention is:
12 parts in 15 parts of Poria of 15 parts of Radix Codonopsis of Fructus Psoraleae
9 parts of 12 parts of Radix Salviae Miltiorrhizaes of 12 parts of Fructus Ligustri Lucidi of the Rhizoma Atractylodis Macrocephalae
Above-mentioned each component is made medicine production method of the present invention is:
1, get Poria, the Rhizoma Atractylodis Macrocephalae with 50% alcohol heating reflux twice, each two hours, filter, merging filtrate reclaims ethanol,
Be concentrated into the thick paste of relative density 1.35-1.4 (50-60 ℃), be ground into fine powder behind the vacuum drying.
2, get Radix Salviae Miltiorrhizae with 70% alcohol heating reflux twice, each two hours, filter, merging filtrate reclaims ethanol, is concentrated into
The thick paste of relative density 1.35-1.4 (50-60 ℃) is ground into fine powder behind the vacuum drying.
3, medicinal residues and Fructus Psoraleae, Radix Codonopsis, the Fructus Ligustri Lucidi with Poria, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae adds ten times of water gagings, decocts twice, for the first time
2 hours, 1.5 hours for the second time, collecting decoction filtered, and filtrate is concentrated into about 1.16 (50 ℃) of relative density, adds ethanol
Make that to contain alcohol amount be 60%, stir evenly, left standstill 24 hours, get supernatant, reclaim ethanol, being concentrated into relative density is 1.3
The thick paste of (55-60 ℃) with Poria, the Rhizoma Atractylodis Macrocephalae, the adding of Radix Salviae Miltiorrhizae fine powder of above-mentioned preparation, stirs the back and forms fine particle,
Drying is crossed 60 mesh sieves, and sterilization incapsulates.
Main feature of the present invention:
1, this invention medicine and tumor chemotherapeutic drug synergism, embody dialectical with debate disease, topical therapeutic and wholistic therapy, anticancer with set upright treatment and combine.This is because medicine of the present invention is longer than strengthening the body resistance, can strengthen patient's immunologic function and anti-cancer ability, regulate patient's negative and positive, zang-fu disharmony, but its tumor-inhibiting action is slower, relatively poor; The chemicals antitumaous effect is stronger, but bigger toxic and side effects is arranged.The collaborative chemotherapy of medicine of the present invention kills and wounds cancerous cell, and the infringement of chemotherapy is avoided or reduced to the organismic internal environment that adequately protected again.Clinical cure rate and patient's life quality is improved.
2, this invention medicine is in kidney tonifying spleen invigorating, the body resistance strengthening and constitution consolidating, raising immunity, in addition the blood-activating and stasis-removing Radix Salviae Miltiorrhizae; Clinical practice shows, many cancer patients have the existence of syndrome of blood stasis, particularly after accepting chemotherapy, patient's syndrome of blood stasis due to qi deficiency occurrence rate obviously increases and increases the weight of, show as the appearance of picture of the tongue and the objective disease of traditional Chinese medical science blood stasis, the microcosmic aspect detects high blood coagulation state (variation of the imbalance of microcirculation change, blood coagulation and fibrinolytic system, thromboxane and prostate metabolite), simultaneously, and the syndrome of blood stasis of tumor patient and the recurrence of tumor and shift closely related.The application of Radix Salviae Miltiorrhizae in this compound recipe solved the syndrome of blood stasis of tumor patient pointedly, Radix Salviae Miltiorrhizae can microcirculation improvement, change hypercoagulability, promote blood circulation, strengthen the groundwater increment of tumor tissues blood and the oxygen content of diseased region cancerous cell, reduce anoxic cell, improve the sensitivity of chemotherapy.
3, this invention medicine adopts capsule formulation, and solvent-applied is extracted, overcome the oral liquid quasi drugs and often only use extraction process by water, the composition that just is dissolved in water that is contained, then production produce in the process mass efficient lipotropy composition fully proposition make their drug effect be subjected to very big influence.
Clinical drug of the present invention uses the result to show that following advantage is arranged:
1, to select natural Chinese medicinal herb for use be raw material in the present invention, and each component meets the pharmaceutical control law regulation, utilizes the auxiliary tumor patient chemotherapy of comprehensive function of the Chinese medicine of respectively distinguishing the flavor of, to human body nonhazardous effect.
2, the present invention is a capsule formulation, extracts through modern crafts to form, and carries and taking convenience, meets state food health legislation regulation.
3, under Isodose chemotherapy prerequisite, tumor patient uses this invention medicine to merge chemotherapy to improve curative effect than simple chemotherapy, reduces toxic and side effects due to the chemotherapy.
4, the price of this invention Chinese medicinal capsule obviously is better than medicines such as expensive hemopoietic growth factor, ondansetron.Be convenient to wide clinical application.
Embodiment (is example to make 1000 No. 0 capsules)
Take by weighing raw material by following proportioning
1.5 kilograms in 1.875 kilograms of Poria of 1.875 kilograms of Radix Codonopsis of Fructus Psoraleae
1.125 kilograms of 1.5 kilograms of Radix Salviae Miltiorrhizaes of 1.5 kilograms of Fructus Ligustri Lucidi of the Rhizoma Atractylodis Macrocephalae
Production method is as follows:
Get Poria, each 1.5 kilograms of usefulness 50% alcohol heating reflux twice of the Rhizoma Atractylodis Macrocephalae earlier, each two hours, filter, merging filtrate reclaims ethanol, is concentrated into the thick paste of relative density 1.35-1.4 (50-60 ℃), is ground into fine powder behind the vacuum drying; Radix Salviae Miltiorrhizae is handled with 70% ethanol with quadrat method.Medicinal residues and Fructus Psoraleae, Radix Codonopsis, Fructus Ligustri Lucidi with Poria, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae adds ten times of water gagings jointly then, decoct twice, 2 hours for the first time, 1.5 hours for the second time, collecting decoction filtered, filtrate is concentrated into about 1.16 (50 ℃) of relative density, add ethanol and make that to contain alcohol amount be 60%, stir evenly, left standstill 24 hours, get supernatant, reclaim ethanol, being concentrated into relative density is the thick paste of 1.3 (55--60 ℃), with Poria, the Rhizoma Atractylodis Macrocephalae, the adding of Radix Salviae Miltiorrhizae fine powder of above-mentioned preparation, stir the back and form fine particle, cross 60 mesh sieves, sterilization incapsulates.
Claims (5)
1, a kind of Chinese prescription that is used for the chemotherapy of tumors patients is made up of Fructus Psoraleae, Radix Codonopsis, Poria, the Rhizoma Atractylodis Macrocephalae, Fructus Ligustri Lucidi, Radix Salviae Miltiorrhizae.
2, a kind of medicine of adjuvant for chemotherapy of tumour is characterized in that it is the medicament of being made by the following weight proportion raw material
Fructus Psoraleae 15-25 part Radix Codonopsis 15-25 part Poria 10-15 part
Rhizoma Atractylodis Macrocephalae 10-15 part Fructus Ligustri Lucidi 10-15 part Radix Salviae Miltiorrhizae 6-15 part
3, according to the medicine of the described adjuvant for chemotherapy of tumour of claim 2, wherein the optimum weight proportioning of each raw material is
12 parts in 15 parts of Poria of 15 parts of Radix Codonopsis of Fructus Psoraleae
9 parts of 12 parts of Radix Salviae Miltiorrhizaes of 12 parts of Fructus Ligustri Lucidi of the Rhizoma Atractylodis Macrocephalae
4,, it is characterized in that said medicament is a capsule according to the medicine of right 1,2,3 described adjuvant for chemotherapy of tumour.
5, the preparation method of the described adjuvant for chemotherapy of tumour medicine of claim 4 is characterized in that Poria, the Rhizoma Atractylodis Macrocephalae, Radix Salviae Miltiorrhizae by behind the ethanol extraction, are dried to fine powder.Its medicinal residues and other medicines decoct jointly, and filtrate is by concentrating after the ethanol sedimentation, to thick paste, with Poria, the Rhizoma Atractylodis Macrocephalae, the Radix Salviae Miltiorrhizae fine powder mixing after the said extracted, porphyrize, incapsulate after sieving, sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98102133 CN1199632A (en) | 1998-05-13 | 1998-05-13 | Chinese medicine preparation as adjuvant for chemotherapy of tumour and its preparation process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 98102133 CN1199632A (en) | 1998-05-13 | 1998-05-13 | Chinese medicine preparation as adjuvant for chemotherapy of tumour and its preparation process |
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| Publication Number | Publication Date |
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| CN1199632A true CN1199632A (en) | 1998-11-25 |
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| CN 98102133 Pending CN1199632A (en) | 1998-05-13 | 1998-05-13 | Chinese medicine preparation as adjuvant for chemotherapy of tumour and its preparation process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095379C (en) * | 1999-10-22 | 2002-12-04 | 黄海平 | Chinese medicine for detoxicating wound and its preparing process |
| CN102755560A (en) * | 2012-08-09 | 2012-10-31 | 南京中医药大学 | Traditional Chinese medicine compound reducing chemotherapy side reaction and preparation method and application thereof |
| CN102961497A (en) * | 2012-11-29 | 2013-03-13 | 王吉坤 | Chinese herbal compound prescription used for treating chronic diarrhea |
-
1998
- 1998-05-13 CN CN 98102133 patent/CN1199632A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1095379C (en) * | 1999-10-22 | 2002-12-04 | 黄海平 | Chinese medicine for detoxicating wound and its preparing process |
| CN102755560A (en) * | 2012-08-09 | 2012-10-31 | 南京中医药大学 | Traditional Chinese medicine compound reducing chemotherapy side reaction and preparation method and application thereof |
| CN102961497A (en) * | 2012-11-29 | 2013-03-13 | 王吉坤 | Chinese herbal compound prescription used for treating chronic diarrhea |
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