CN1194777C - Artificial skin and its prepn and use - Google Patents
Artificial skin and its prepn and use Download PDFInfo
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- CN1194777C CN1194777C CNB011417617A CN01141761A CN1194777C CN 1194777 C CN1194777 C CN 1194777C CN B011417617 A CNB011417617 A CN B011417617A CN 01141761 A CN01141761 A CN 01141761A CN 1194777 C CN1194777 C CN 1194777C
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Abstract
The present invention provides artificial skin which is composed of the components with the proportion by weight: 0.1 to 30 portions of framework materials and 1 portion of polysaccharide, and the artificial skin can also comprise ingredients. The artificial skin of the present invention is divided into two kinds of specifications, namely artificial skin with holes and artificial skin without holes. The artificial skin of the present invention can be used for treating burns, wounds, frostbite and ulcers of a superficial II degree, a deep II degree and a superficial III degree and the aspect of beauty treatment. An experiment proves that wound surfaces can be effectively protected by covering wounds with the artificial skin, the healing of wound surfaces can be promoted, and the problem of wound transudate can also be solved. The problem of bacterial infection in the course of skin healing is prevented and treated. The stimulation to skin is reduced, the artificial skin has better flexibility and intensity, and people do not have injuries and pain when the artificial skin is torn out from wound surfaces.
Description
Technical field
The present invention relates to medical domain, a kind of artificial skin that is used for surgery flap coverage and 2,3 grades of wounds is provided.
Background technology
At present, the dressing that is used for the treatment of the skin trauma face is numerous, generally is divided into common dressing, biological dressing and synthetic dressing three major types.People generally are called " artificial skin " to membranaceous dressing visually.Reasonable artificial skin is by polymer compounds or tablet or the membranoid substance made by biopolymer.But, the covering of forming by polymer compounds only, as forming by polyurethane, or the covering of polyurethane and ether material composition, though it has good physics characteristic, very firm, permeable, ventilative, but only finished the task of protection wound surface, do not have the wound surface of the stimulation restorative character of growing; On the other hand; the covering of forming by biopolymer only; as form by ossein or form by the mixture of gelatin and chitosan; the perhaps covering of forming by ossein chitosan and amine sugar polymer; can stimulate the growth of wound surface well, but physics's character is very poor: very crisp when drying, cracky very when moistening; and under the effect of wound fluid enzyme, be decomposed very soon, can not finish the protection task.CN1117708 has introduced a kind of absorbefacient Wound dressing in addition, mainly be to reach the purpose that absorbs the wound transudate by adding hydrophilic polymer, but that it has only reached the protection wound is no longer infected, can not promote wound healing; CN1162268 has introduced a kind of improved moisture vapor permeability, damages low wound dressing; CN1095916 has introduced the wound dressing that a kind of polymer is made bottom, thinks that this is a kind of novel wound dressing that has excellent absorbability and can prevent seepage, wherein contains successive and discrete moisture colloid of separating.But all there is such defective in they, and zest is promptly arranged, and make skin that little burning sensation be arranged; Intensity a little less than, easily split frangible during use; When having the wound surface of oozing out to use, infect easily; Complicated process of preparation.
Summary of the invention
Artificial skin provided by the present invention technical essential to be solved is to protect wound surface effectively, and can promote the healing of wound surface, solves the problem of wound fluid and the bacterial infection problem in prevention and the treatment skin healing process; Reduced the zest to skin in addition, had pliability and intensity preferably, quality is uniform and smooth; And protecting film is a transparence, can observe the treatment situation of wound face at any time; And preparation technology of the present invention is simple.
Artificial skin of the present invention is made up of framework material and polysaccharide, and wherein the proportioning of framework material and polysaccharide is 0.1-30: 1, be preferably 0.5-20: 1.
Wherein said framework material refers to form the framework material of latex or solution, and they are silicone rubber, fluorubber, polyethylene, polyvinyl alcohol, polyurethane, polyacrylic resin, polyurethane, polyimide polymer; Be preferably polyacrylic resin, fluorubber, silicone rubber, polyurethane and polyvinyl alcohol; The best is fluorubber, silicone rubber, and wherein fluorubber is to mix polymer by what difluoroethylene and trifluoro-ethylene or hexafluoroethylene formed.
The framework material that the present invention selects for use at first, have microbial barrier and pass, is effectively protected wound surface, can be good at preventing the infection again of wound surface; Secondly, it has certain mechanical strength and compliance, provides enough intensity and toughness to artificial skin; It has biocompatibility preferably once more, has reduced the stimulation to human body skin; Last its has network structure and hydrophobicity, and this makes artificial skin have steam permeability preferably; Batching and polysaccharide can be entrenched in to be beneficial in the network structure to wound and discharge, and help kill bacteria, and the nutrition wound surface is accelerated the healing of wound; In addition, it has certain hydrophobicity, this make artificial skin not can with wound adhesion tension, take Shi Buhui off and cause the pain of wound surface and destroy wound surface.
Wherein said polysaccharide is a water soluble polysaccharide, and they are chitosan, chitosan, cellulose, Algin, carrageenan, gelatin, zein gelatin, arabic gum and pregelatinized Starch.Be preferably cellulose, Algin, carrageenin or its salt and derivant thereof.The best is carrageenin, alginate and cellulosic mixture, wherein the ratio between carrageenin, alginate and the cellulose is 1: 1-20: 1-30, wherein carrageenin is one or more in K (Kappa), I (Iata), λ (Lambda) the type carrageenin, and alginate is one or more in alignic sodium salt, potassium salt, the calcium salt; Cellulose is one or more in methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, ethyl cellulose, cellulose acetate, cell cellulose, the polypropylene cell cellulose.
The present invention selects for use water soluble polysaccharide to make raw material, has following multiple efficacies: 1. the polysaccharide possess hydrophilic property can absorb wound fluid, thereby eliminates the problem of wound fluid; 2. polysaccharide all is the trophism polysaccharide, can provide nutritional labeling to wound skin, thereby can promote the healing of wound skin; 3. polysaccharide has cohesiveness, can substitute binding agent, guarantee the bonding of artificial skin and human body skin, thereby realize that artificial skin does not contain the purpose to skin binding agent excitatory, have polyhydroxy as cellulose, have better water solubility, hydroxyl is exposed to the film surface after the film forming, makes wound surface is had sticking pair of certain effect; Alginate is the anion state in wound fluid, can stimulate epidermis cell free and growth to wound surface of positively charged, promotes the healing of wound surface, and preventing from scar, wherein carrageenin has the inhibition connective tissue growth, the protection wound surface.
Can also contain medicines such as an amount of antibacterial, antifungal, hemorrhage, protein dissolution agent, Wound-healing agent and vitamin in the artificial skin of the present invention prepares burden.Wherein antibacterial is one or more of organic silver, inorganic silver salt, chloromycetin, lincomycin, gentamycin, hibitane, povidone iodine, idoxuridine, hibitane, and wherein organic silver can be sulfadimidine silver, kynix Qin Yin, sulfanilamide dimethylthiazole silver; Wound-healing agent is preferably short more element, auxin, epidermal growth factor, polypeptide growth factor, recombination human basic and is in the very thin intracellular growth factor one or more; Antifungal drug is quinolones, miconazole class, fluconazol class, ketoconazole class, econazole class, clotrimazole class medicine; Vitamin is one or more of vitamin C, vitamin A, vitamin E; The protein dissolution agent is a trypsin.
These medicine batchings can be entrenched in the network structure of framework material equally, are beneficial to wound surface to discharge, and kill residual and antibacterial and virus that may invade, make wound surface accelerate healing simultaneously.
For the artificial skin that the present invention is made Paint Gloss, pliable and tough flexible, can also add surfactant and plasticizer in the artificial skin of the present invention in addition, because surfactant and plasticizer require no side effects, thus the present invention to require it be surfactant and the plasticizer that meets state quality standard; Must meet the surfactant of national standard L14233.4-93 defined between the 0-2 degree as surfactant, it can be TWEEN-80, SLS (sodium lauryl sulphate); Plasticizer can be PEG class (400-800), PVP class or glycerol.
Its thickness of artificial skin of the present invention is 0.01-3.4mm, and its steam permeability is 1-8mg/cm
2H, unit water absorbability are 0.5-20 times of artificial skin own wt, and the hemadsorption ability artificial skin own wt 0.5-20 of unit times, the pH value scope is 3.0-8.0.
According to the practical situation of patient's wound surface, artificial skin of the present invention can be made porose and artificial skins two kinds of specifications of atresia, and the aperture of the artificial skin of wherein foraminous the present invention should be 0.05-5mm.
Artificial skin of the present invention can adopt following method to prepare: framework material is added make uniform state suspension solution or emulsion in the entry; add polysaccharide solution and batching then in right amount; remove big insoluble particles mix homogeneously after filtration; make film then, dry 48 hours, behind the bone dry; take off film; cutting, packing, sterilization.If preparation needs the artificial skin of punching, between cutting and packaging step, increase punch out step.
Artificial skin of the present invention is applicable to burn, scald, chemical burn, skin donor site wound surface, mesh graft wound surface, the burn later stage residual wound of the shallow II of treatment of shallow II, dark II, shallow III degree, dark II, shallow III degree, exogenous injury of human body wound surface, cold injury, the external treatment of hindering wound surface, decubital ulcer and beauty treatment aspect of ulcer.
Confirm through test, cover wound with this artificial skin, can in fortnight, guarantee fibroblastic remarkable regeneration, zest to skin is low, pliability and intensity are preferably arranged, and owing to selected for use above-mentioned raw materials to make that the artificial skin of finally making is a transparence, this makes people can see through the treatment situation that this artificial skin is observed wound face at any time.Because artificial skin of the present invention is to have selected for use hydrophilic polysaccharide and hydrophobic framework material to make raw material, thereby can not produce pain to artificial skin patient when wound face is taken off.
Embodiment 1
Get the serum of 1.5 liters of fluorubber, making it through slot size is the filter filtration of 0.1-0.2mm, and the content of solid matter is 360g/l, gets the aqueous solution (containing 10g Karraginan altogether, the sodium salt of 20g Algin acid and 30g methylcellulose) of 2 liters of polysaccharide again.Above liquid evenly being stirred, make it fully to be mixed into one, is the mixture that obtains the filter filtration of 0.1-0.2mm by slot size once more.Mixture is poured on the glass plate, makes every liter of mixture be poured on 1.0-1.2m
2Area on, drying at room temperature makes it to form bone dry, thickness is the film of 0.1mm, the film of well cutting is packaged into pack, with the gamma-radiation sterilization of 2.5Mpag.
Embodiment 2
Get the serum of 1.0 liters fluorubber, after example 1 filtration, get aqueous solution (the 4 gram carrageenin of 3 liters of polysaccharide, the sodium salts of 20 gram Algin acid and 30 gram methylcellulose) and 10 milliliters of idoxuridine solution, by example 1 preparation mixture, do film forming, and on film, stamp the hole that diameter is 0.1mm according to pitch of holes 15mm.
Embodiment 3
Get the serum of 0.75 liter of fluorubber, after the filtration, the content of solid matter is 360g/l, gets the aqueous solution (8 gram carrageenin, the sodium salt of 20 gram Algin acid and 30 gram methylcellulose) and an amount of Tween-80 of 4 liters of polysaccharide again, does film forming by example 1.
Embodiment 4
Get the serum of 0.25 liter of fluorubber, after the filtration, the content of solid matter is 360g/l (set-up procedure is seen example 1), and the aqueous solution of getting 3 liters of polysaccharide again (contains 7 gram carrageenin altogether, the sodium salts of 21 gram Algin acid and 32 gram methylcellulose) and glycerol an amount of, do film forming by example 1.
Embodiment 5
Methylcellulose 4g, sodium alginate 4g, rhbFGF0.3mg are dissolved in the 200ml purified water, mix with the 200ml rubber latex, are applied on the glass plate, 60 ℃ of dryings 8 hours, take artificial skin off, stamp the hole that diameter is 0.5mm according to the pitch of holes of 17mm, cutting is packaged into 32 of 10 * 12mm specifications.
Embodiment 6
Carboxymethyl cellulose 4g, gelatin 1g, carrageenan 2g are dissolved in the 200ml purified water, mix with the 150ml acrylic resin, are applied on the glass plate, 60 ℃ of dryings 6 hours, take artificial skin off, stamp the hole that diameter is 2mm according to the pitch of holes of 10mm, cutting pack 25 of 10 * 12mm specifications.
Embodiment 7
Collagen protein 4g, calcium alginate 2g carboxylic propyl methocel 0.5g are dissolved in the 200ml purified water, mix with the 100ml poly-vinyl alcohol solution, be applied on the glass plate, 60 ℃ of dryings 6 hours, take artificial skin off, stamp the hole that diameter is 5nm according to the pitch of holes of 20mm, cutting pack 24 of 10 * 12mm specifications.
Embodiment 8
Carboxymethyl cellulose 2g, calcium alginate 1g, carrageenan 0.5g, PEG0.2g, PVP0.1g, sulfanilamide dimethylthiazole silver 2g are dissolved in the 200ml purified water, mix with 200ml silicone rubber, be applied on the glass plate, 50 ℃ of dryings 10 hours, take artificial skin off, stamp the hole that diameter is 3nm according to the pitch of holes of 19mm, cutting pack 30 of 10 * 12mm specifications.
Experimental example 1, the artificial skin clinical experiment report of the present invention
One, experiment condition
The artificial skin of the present invention semi-annular jade pendant top hospital burn department of giving birth in Center Hospital of Jinan City Department of B urn and Yantai City respectively carries out observation on Clinical Application, totally 100 examples, wherein male 70 examples, women 30 examples; The maximum burn surface area of case is 80/65%, minimum burn surface area 1%, dark II ° of average 15.21/8.81%; Artificial skin area coverage maximum 6%, minimum 1%, average out to 1.28%, the longest application time are 18 days, the shortest application time is 6 days.
Two, clinical clinical experiment situation is observed:
1, shallow II ° wound surface:
Semi-annular jade pendant top hospital burn department is given birth all in hindering in back 24 hours by the Yantai City, thoroughly sticks artificial skin after the debridement with the wrapping of 3-5 layer sterile gauze, and the oil gauze contrast is hindered 8～14 days artificial skins in back and purified wound healing.Contrast Oleum Radix Arnebiae (Oleum Radix Lithospermi) gauze does not heal yet.The artificial skin covering part contrasts the oil gauze position and healed in advance 3～5 days.The fresh shallow II ° wound surface of Center Hospital of Jinan City Department of B urn 14 examples, existing shallow II ° of wound surface 1 example that infects sign.All carry out covering artificial skin after the thorough debridement, same wound surface, with paraffin oil gauze or the contrast of Oleum Radix Arnebiae (Oleum Radix Lithospermi) gauze, back 5-7 days more change dressingses are hindered in conventional 25-50 layer sterile gauze wrapping.Significantly short more effect is arranged, and the most obvious than contrast healing in 6 days in advance, the shortest wound surface that contrasts healed healing in average 3.6 days in 2 days in advance.The position that covers than oil gauze after the position healing that the perusal artificial skin covers is more near normal skin, and the epithelium keratinization is better.Shallow II ° of wound surface 1 example that infects sticks after the debridement well, and no hydrops contrasts position healing in 3 days in advance.Do not show other untoward reaction.Wound surface test group and matched group that it should be noted that this group patient are all implemented strict asepsis debridement, any antibacterials of wound surface.
2, dark II ° of wound surface:
Yantai City's semi-annular jade pendant top hospital burn department of giving birth is used 3 examples, stick behind the oil gauze because of slough retains inflammatory reaction, after change into and stick the SD-Ag artificial skin and heal; The Center Hospital of Jinan City Department of B urn is used the artificial skin of the present invention and is covered dark II ° burn wound 17 examples, the infected's two examples when being admitted to hospital, and wound surface external oil gauze and chlormycetin powder are a case each when covering the artificial skin of the present invention; Cover after the 15 routine debridements, wherein 4 routine wound surface are used oil gauze, any medicine of 11 routine debridement postoperative wound surfacees, and 9 examples all have gently, the moderate hydrops infects sign, through changing the spontaneous recovery of SD-Ag artificial skin.
3, skin donor site wound surface:
Semi-annular jade pendant top hospital burn department 4 examples are given birth after skin donor site cuts the thin split-thickness skin graft that thickness is 0.2～0.3mm by the Yantai City, stick artificial skin.A little hydrops under 1～2 day artificial skin of postoperative is removed hydrops, pastes artificial skin again, and 11～15 days artificial skins of postoperative purify the skin donor site wound healing; The matched group kpetrolatum gauze does not purify yet, artificial skin healed 2～4 days in advance than matched group, Department of B urn the present invention artificial skin in Center Hospital of Jinan City covers 17 examples, oil gauze covers wherein sword pachydermia, middle pachydermia 16 examples, and wound surface all need not any antibacterials, wherein 16 examples have tangible promotion healing effect, none example infects, hydrops, the healing in the fastest 7 days of the thick skin donor site of sword; 17 examples are healing in 2-5 days in advance all, and average 3,4 days, the position that covers than oil gauze, the position that covers of artificial skin was more near normal skin simultaneously, and the epithelium keratinization is better.
4, granulation wound:
The Center Hospital of Jinan City Department of B urn covers artificial skin 5 examples of the present invention, all be to cover artificial skin after the debridement, contrast is oil gauze, equal externally used antimicrobial medicine, cover this type of wound surface with the present invention's artificial skin with holes, ooze out more very fast, prolong observation to 3 hours (1 example) after covering artificial skin, the granulation tissue comparatively fresh that artificial skin covers, granulation is knitted close, oozes out fewly than oil gauze, and residual wound surface is the autologous transplanting skin subsequently, the short more effect on granulation tissue of wound closure, the artificial skin of the present invention is more obvious.
5, skin-grafting area wound surface:
Center Hospital of Jinan City Department of B urn artificial skin covers skin-grafting area 3 examples, opens self-skin transplant 1 example greatly, and little stamp is transplanted 2 examples, has significantly short more sign.
6, the damaged wound surface of excoriation:
Center Hospital of Jinan City Department of B urn artificial skin is used dark II ° wound surface 1 example of excoriation for just healing in the recent period, artificial skin covering part healing in 9 days after the debridement, the healing in 12 days of gauze covering part.
7, infective wound surface:
Center Hospital of Jinan City Department of B urn artificial skin is used 3 examples, wherein there be II ° of burn infection slough to purify 1 example, degree of mixing traumatic infection partial necrosis is organized still residual 2 examples, and all external SD-Ag artificial skin contrast position oil gauze has significantly short more effect after debridement.
Three, sum up
By to using the artificial skin of the present invention to amount to 100 examples, the patient of 7 class wound surface, the clinic trial of lasting 6 months is observed and is shown, the artificial skin of the present invention is non-stimulated, and sensitization does not have the anxiety that absorbs poisoning, obviously short more effect being arranged, and closure, ventilative water permeability are moderate; And raw material of the present invention is cheap than horn of plenty, and particularly clinical practice is at the fresh shallow two degree wound surface of burn, and the skin donor site wound surface shows that quickening wound healing characteristics are more obvious, has pliability and intensity preferably.
Claims (13)
1. artificial skin limb is characterized in that it is made up of framework material and polysaccharide, and the weight ratio of framework material and polysaccharide is 0.1-30: 1; Wherein framework material is for forming the framework material of latex or solution, and they are a kind of, two or more combination in silicone rubber, fluorubber, polyethylene, polyvinyl alcohol, polyacrylic resin and the polyimide polymer; Polysaccharide is a water soluble polysaccharide, and they are a kind of, two or more combination in cellulose, Algin, carrageenan, chitosan, chitosan, gelatin, arabic gum and the pregelatinized Starch.
2. artificial skin according to claim 1, the weight proportion that it is characterized in that framework material and polysaccharide is 0.5-20: 1, wherein framework material is for forming the framework material of latex, and they are a kind of, two or more combination in silicone rubber, fluorubber, polyethylene, polyvinyl alcohol, polyacrylic resin and the polyimide polymer; Wherein polysaccharide is a water soluble polysaccharide, and they are a kind of, two or more combination in cellulose, Algin, carrageenan, chitosan, chitosan, zein gelatin, arabic gum and the pregelatinized Starch.
3. artificial skin according to claim 1 and 2 is characterized in that framework material is a kind of, two or more combination in polyacrylic resin, fluorubber, silicone rubber and the polyvinyl alcohol; Polysaccharide is a kind of, two or more combination in Algin or its salt, cellulose and carrageenin and the derivant thereof.
4. artificial skin according to claim 3, wherein framework material is for forming the fluorubber or the silicone rubber of latex; Wherein polysaccharide is carrageenin, alginate and cellulosic mixture, and the part by weight between the carrageenin, alginate, cellulose is 1: 1-20: 1-30.
5. artificial skin according to claim 4, the dish glue that wherein intersects are K (Kappa), I (Iata), λ (Lambda) type intersection dish glue, and alginate is alignic sodium salt, potassium salt, calcium salt; Cellulose is a kind of, two or more combination in methylcellulose, carboxymethyl cellulose, hydroxypropyl cellulose, ethyl cellulose, cellulose acetate, cell cellulose and the polypropylene cell cellulose.
6. according to the described artificial skin of claim 1 claim, it is characterized in that also containing batching, it is to be a kind of, two or more combination in antibacterial, antifungal, hemorrhage, protein dissolution agent, Wound-healing agent and the vitamin.
7. artificial skin according to claim 6 is characterized in that antibacterial is a kind of, two or more combination in organic silver, inorganic silver salt, quinolones, chloromycetin, lincomycin, gentamycin, idoxuridine, hibitane and the povidone iodine; Organic silver is a kind of, two or more combination in sulfadimidine silver, sulfamethoxypyridazine silver and the sulfanilamide dimethylthiazole silver; Antifungal drug is a kind of, two or more combination of miconazole class, fluconazol class, ketoconazole class, quinolones, econazole class and clotrimazole apoplexy due to endogenous wind; Wound-healing agent is that auxin, epidermal growth factor, polypeptide growth factor and recombination human basic are a kind of, two or more combination in the very thin intracellular growth factor; Vitamin is a kind of, two or more combination in vitamin C, vitamin A and the vitamin E; The protein dissolution agent is a trypsin.
8. artificial skin according to claim 6, it also contains surfactant and plasticizer, and wherein surfactant is TWEEN-80, sodium lauryl sulphate.
9. artificial skin according to claim 8, plasticizer are that glycerol, PVP class or model are the PEG class of 400-800.
10. according to claim 1 or 6 or 8 described artificial skins, it is characterized in that its thickness is 0.01-3.4mm, its steam permeability is 1-8mg/cm
2H, unit water absorbability are 0.5-20 times of artificial skin own wt, and unit hemadsorption ability is artificial skin own wt 0.5-20 times, and the pH value scope is 3.0-8.0.
11. the preparation method of the described artificial skin of claim 1 is characterized in that framework material added and makes uniform state suspension solution or emulsion in the entry, adds polysaccharide solution then, after filtration, remove big insoluble particles, mix homogeneously is made film then, dry 48 hours, behind the bone dry, take off film, cutting, packing, sterilization.
12. according to the preparation method of the described artificial skin of claim 11, it is characterized in that framework material added and make uniform state suspension solution or emulsion in the entry, add polysaccharide and ingredients solution then; after filtration; remove big insoluble particles mix homogeneously, make film then, dry 48 hours; behind the bone dry; take off film, cutting, punching; packing, sterilization.
13. the described artificial skin of claim 1 is used for the treatment of the purposes of the product aspect burn, scald, chemical burn, skin donor site wound surface, mesh graft wound surface, burn later stage residual wound, exogenous injury of human body wound surface, cold injury, ulcer, decubital ulcer and the beauty treatment of shallow II, dark II, shallow III degree in preparation.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011417617A CN1194777C (en) | 2000-10-11 | 2001-09-18 | Artificial skin and its prepn and use |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN00129758 | 2000-10-11 | ||
| CN00129758.9 | 2000-10-11 | ||
| CNB011417617A CN1194777C (en) | 2000-10-11 | 2001-09-18 | Artificial skin and its prepn and use |
Publications (2)
| Publication Number | Publication Date |
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| CN1347736A CN1347736A (en) | 2002-05-08 |
| CN1194777C true CN1194777C (en) | 2005-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB011417617A Expired - Fee Related CN1194777C (en) | 2000-10-11 | 2001-09-18 | Artificial skin and its prepn and use |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1883438A (en) * | 2005-06-21 | 2006-12-27 | 香港理工大学 | Temperature responsive intelligent facial mask and method for preparing same |
| CN1319605C (en) * | 2005-12-07 | 2007-06-06 | 浙江大学 | Collagen-chitin and silicon rubber bilayer skin regeneration support and its preparation method |
| CN102961786B (en) * | 2012-11-26 | 2014-06-11 | 中国人民解放军第三军医大学第一附属医院 | Porous silicon rubber film for artificial skin |
| CN103341204B (en) * | 2013-06-04 | 2015-08-05 | 青岛中腾生物技术有限公司 | A kind of antibacterial repair materials and preparation method thereof |
| CN104436275B (en) * | 2014-11-07 | 2016-08-24 | 南通华盛高聚物科技股份有限公司 | A kind of medical polyurethane film and preparation method thereof |
| CN105561400B (en) * | 2015-12-30 | 2019-12-13 | 广州迈普再生医学科技股份有限公司 | Artificial dermis stent and preparation method thereof |
| TWI577395B (en) * | 2016-06-14 | 2017-04-11 | Chen ming-hong | Nano - silver colloidal wound dressing film and its preparation method |
| CN106421930A (en) * | 2016-11-03 | 2017-02-22 | 常州亚环环保科技有限公司 | Preparation method of nonirritating artificial skin |
| CN107929806B (en) * | 2017-12-19 | 2021-01-12 | 范娟 | Preparation method of artificial skin special for burns |
| CN108392681B (en) * | 2018-01-25 | 2021-04-06 | 山东美毅生物技术有限公司 | Artificial skin material and preparation method thereof |
| CN112472873A (en) * | 2018-09-23 | 2021-03-12 | 湖南博隽生物医药有限公司 | Preparation method of artificial skin material |
| TWI714373B (en) * | 2019-11-29 | 2020-12-21 | 國立中央大學 | A composite fiber |
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2001
- 2001-09-18 CN CNB011417617A patent/CN1194777C/en not_active Expired - Fee Related
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| CN1347736A (en) | 2002-05-08 |
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Owner name: SHANDONG LUYE PHARMACEUTICAL CO., LTD. Free format text: FORMER NAME OR ADDRESS: SHANDONG GREEN LEAF PHARMACEUTICAL CO., LTD. |
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| CP01 | Change in the name or title of a patent holder |
Address after: 264003, No. 9, Po Yuen Road, Laishan District, Shandong, Yantai Patentee after: Shandong Luye Pharma Co., Ltd. Address before: 264003, No. 9, Po Yuen Road, Laishan District, Shandong, Yantai Patentee before: Luye Pharmaceutical Co., Ltd., Shandong |
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