CN1188167C - 减毒水痘活疫苗质量控制的方法 - Google Patents
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Abstract
公开的是一种对减毒水痘活疫苗进行质量控制的方法，该方法包括把水痘疫苗病毒样品的基因组DNA进行序列分析和证实水痘疫苗病毒样品的基因组DNA中第5,745位的G、第105,356位的C、第105,544位的G、第106,262位的C和第107,252位的C是保守的而没有发生突变，其中的核苷酸编号与SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的。
Description
发明背景
发明领域
本发明涉及减毒水痘活疫苗质量控制的一种方法。更特别地，本发明涉及减毒水痘活疫苗质量控制的一种方法，该方法包括把水痘疫苗病毒样品的基因组DNA进行测序分析和证实水痘疫苗病毒样品的基因组DNA中特异的核苷酸是保守的而没有突变。通过应用本发明的方法，能够非常准确地确定作为减毒水痘活疫苗的活性成份的减毒水痘病毒的合格性，因而进行准确的疫苗质量控制。
在先技术
众所周知，今天应用的减毒水痘活疫苗是从水痘病毒的一个种子株中生产的，该水痘病毒是从减毒水痘病毒Oka株中得到的(参见已审查的日本专利申请，公开号53-41202号和美国专利3,985,615号)，并且减毒疫苗在世界上被广泛应用(要求水痘疫苗(活)于1984采用；修改于1993；WHO技术报告系列第848号，22-38页，1994)。考虑到在传代中可能会发生潜在的遗传突变，为保证疫苗的安全性和有效性，在种子批次***控制下限制用来生产疫苗的病毒的传代次数。那就是，制造商有责任只从来自被批准的种子病毒的病毒生产活性水痘疫苗，其中病毒的传代数从算作0代的被批准的种子病毒起不能超过10代。换句话说，减毒水痘活疫苗的质量控制和质量保证依赖于制造商实行种子批次***，这样的质量控制和质量保证的方法也不是本领域的技术人员可以描述和分析的。
进一步，从涉及描述水痘疫苗的效果和后市场监视(PMS)的流行病学观点来看，需要确定在从自然感染了水痘的病人中分离的新鲜野生株和从上述Oka株中得到的疫苗病毒株之间的病毒学差异，而且不同的分析，例如那些应用了免疫学技术和遗传工程技术的，都被用来确定病毒学的差异。例如，曾报告下面的分析：在不同VZV株间的DNA序列差异(Journal of Virology，59，660-668，1986；和同上，67，1759-1816，1986)、没有或具有限制酶
Pst I酶切位点的差异(JapaneseJournal of Experimental Medicine，59，233-237，1989)、PCR(聚合酶链式反应)产物的RFLP(限制性片断长度多态性)的差异(Journal of Virology，66，1016-1020，1992)和有关PCR产物RFLP差异的限制酶
Pst I酶切位点的有无差异(Journal of Clinical Microbiology，33，658-660，1995)。然而，所有这些分析都只是提出可用来从来自Oka株的疫苗株中区分出新鲜野生型株的标准，并且这些分析缺乏可靠性和准确性。另外，也已知应用基因14区域(美国专利第6,093,535号)鉴定减毒水痘病毒Oka株的方法和应用基因62区域鉴定减毒水痘活疫苗病毒的方法(国际专利申请公开第WO00/50603号)。这两个方法都可以用来确定在水痘病毒Oka株(恶性亲本株)、从它得到的疫苗株(减毒Oka株)和不是Oka株的水痘病毒株之间的差别，但这些方法都不能令人满意地作为减毒水痘活疫苗质量控制和质量保证的标准。
如上所提到的，在当今被用来作为减毒水痘活疫苗的活性成份的减毒水痘病毒的质量是通过制造商执行种子批次***得以控制的。换句话说，可由第三者为评估和证实疫苗的有效性而描述和分析的方法，例如，应用种子病毒或疫苗病毒的基因组DNA直接的和定量的遗传分析的方法，没有用来进行疫苗的质量控制，因而，质量控制的准确性是不可计算的和模糊的。因此，提高质量控制和质量保证的准确性，对于保证减毒水痘活疫苗的有效性、安全性和单一性是非常重要的。然而，如上所述，一个可靠的质量控制方法尚未建立，迫切需要在本领域开发这样的方法。
发明概述
在上述情况下，本发明人已经进行了广泛和深入的研究，以开发一种准确和定量地进行减毒水痘活疫苗质量控制的新方法。特别地，本发明人确定了减毒水痘病毒Oka株超过120,000个核苷酸的全部基因组核苷酸序列，并在减毒Oka株的核苷酸序列和烈性株与亲本Oka株(烈性株)的全基因组核苷酸序列之间进行了比较分析，鉴定了减毒水痘病毒Oka株的基因突变。结果他们发现，通过评估和确定一个水痘病毒株中下面提到的特异核苷酸是否是保守的，就可以把一个其中特异核苷酸是保守的的病毒株准确地确定为能够作为减毒水痘疫苗病毒发挥功能的病毒株。基于此新发现，本发明得以完成。
因此，本发明的一个目标就是提供减毒水痘活疫苗质量控制的一种新方法。
本发明的另一个目标是提供一种减毒水痘活疫苗，它可被上述方法所质量控制。
本发明的进一步的一个目标是提供一种能够作为减毒水痘疫苗病毒发挥功能的疫苗株，它可被在上述方法中应用的方法所鉴定。
从下面的详细描述和附属的权利要求书和与它们一起的序列列表和图示中，本发明前述的和其他的目标、特点和优点，对于在本领域中的熟练人员将是显然的。
无文本的序列列表
SEQ ID NO：3和4是用来检测水痘疫苗病毒的第560位核苷酸突变的PCR引物。
SEQ ID NO：5和6是用来检测水痘疫苗病毒的第5,745位核苷酸突变的PCR引物。
SEQ ID NO：7和8是用来检测水痘疫苗病毒的第26,125位核苷酸突变的PCR引物。
SEQ ID NO：9和10是用来检测水痘疫苗病毒的第94,167位核苷酸突变的PCR引物。
SEQ ID NO：11和12是用来检测水痘疫苗病毒的第105,356、105,544、124,353和124,541位核苷酸突变的PCR引物。
SEQ ID NO：13和14是用来检测水痘疫苗病毒的第105,705、106,262、123,635和124,192位核苷酸突变的PCR引物。
SEQ ID NO：15和16是用来检测水痘疫苗病毒的第107,136、107,252、122,645和122,761位核苷酸突变的PCR引物。
SEQ ID NO：17和18是用来检测水痘疫苗病毒的第108,111和121,786位核苷酸突变的PCR引物。
图示的简要描述
在图示中：
图1是水痘病毒Oka株的遗传图，显示每个基因的数目和方向，其中，_代表同义替换，_代表非同义替换，_代表在非编码区的一个突变，○代表缺失或***，基因组长度被示为每20kb，R1和R4代表重复序列，Ori代表复制起始点，TRL代表“长末端重复”，UL代表“唯一的长”，IRL代表“长内部重复”，IRS代表“短内部重复”，US代表“唯一的短”，TRS代表“短末端重复”；其中基因62到基因64的核苷酸序列，且基因69到基因71的核苷酸序列是互相对称的(即两个核苷酸序列是反向重复序列)；和
图2表示在实施例4中进行的RFLP分析结果的电泳图谱，其中，用来处理PCR产物的限制酶如下：图2(a)应用
Nla III得到，图2(b)应用
Alu I得到，图2(c)应用
BstX I得到，图2(d)应用
SfaN I得到，图2(e)应用
Acc II得到，图2(f)应用
Sac II得到，图2(g)应用
Sma I得到，图2(h)应用
BssH II和
Nae I组合得到，图2(I)应用
Bsr I得到；其中，V代表减毒的Oka株，P代表亲本Oka株，K代表Kawaguchi株。
在本发明中应用的术语被特别定义于下列的(a)到(g)项：
(a)VZV：一种引起水痘和带状疱疹的病毒。“VZV”是“水痘—带状疱疹”的缩写，常常简称为“水痘病毒”。
(b)水痘疫苗病毒和水痘疫苗：水痘疫苗病毒是疫苗的活性成份，它是一种减毒病毒。水痘疫苗是能有效地阻止VZV感染和在其感染后发生疾病的疫苗。
(c)减毒Oka株：减毒Oka株是减毒的水痘病毒Oka株(参见审查的日本专利申请公开53-41202和美国专利第3,985,615号)或从其得到的减毒水痘病毒。减毒Oka株以保存号VR-795在1975年3月14日被保存在ATCC。
(d)亲本Oka株：亲本Oka株是初始分离的野生型(烈性)的水痘病毒Oka株。
(e)质量控制：为保证疫苗的有效性、安全性和单一性，疫苗的原材料、在产生疫苗的过程中得到的中间产物和最终产物，经受多种试验和分析以确认和保证它们作为疫苗的质量。当前，对于减毒水痘活疫苗来说，疫苗的质量控制依照《药品事务法》(法律第145号，立于1960)第42款1项、日本健康和福利部发布的第217号令(Seibutsugakuteki Seizai Kijun，生物制剂的最低要求)中的以“干的减毒水痘活疫苗”为题的条款或上述WHO的“水痘疫苗(活的)的要求”进行。
(f)DNA序列的核苷酸编号：在本发明中，水痘病毒的所有核苷酸编号都与水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的(Journal of General Virology，67，1759-1816，1986和GenBank(国家生物技术信息中心，国家医学图书馆，38A大楼，8N805房间，Bethesda，MD 20894，美国)，登录号第X04370)，结果示于SEQID NO 1。进一步，在本发明中，核苷酸序列是有义链的序列，除非特别说明。
(g)DNA突变：减毒Oka株的基因组DNA中的突变是通过在减毒Oka株、Dumas株和烈性亲本Oka株的核苷酸序列中搜索同源序列而鉴定。例如，如下描述DNA突变：“在减毒Oka株中，Dumas株的第5,745位核苷酸A和烈性亲本Oka株相应位点的核苷酸被突变为G。此核苷酸突变是一个非同义替换，其中Ser被Pro所代替。”
发明的详细描述
在本发明的一个方面，提供了一种进行减毒水痘活疫苗的质量控制的精确方法。
为容易地理解本发明，本发明的必要特点和多个实施例被列于下。
1.减毒水痘活疫苗质量控制的一种方法，包括把水痘疫苗病毒样品的基因组DNA进行序列分析和证实水痘疫苗病毒样品的基因组DNA中下列5个特异核苷酸是保守的而没有发生突变：
第5,745位的G，第105,356位的C，第105,544位的G，第106,262位的C和第107,252位的C。
其中，核苷酸编号与SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的。
2.依据上述1的方法，其中，5个核苷酸结合的保守性被应用下列引物进行的RFLP分析所证实：
SEQ ID NO：5和6的一对引物，证实第5,745位的G；
SEQ ID NO：11和12的一对引物，证实第105,356位的C和第105,544位的G；
SEQ ID NO：13和14的一对引物，证实第106,262位的C；和
SEQ ID NO：15和16的一对引物，证实第107,252位的C。
3.依据上述1或2的方法，该方法进一步包括证实水痘疫苗病毒样品的基因组DNA中下列4个核苷酸是保守的而没有发生突变：
第122,645位的G，第123,635位的G，第124,353位的C，第124,541位的G。
其中，核苷酸编号与SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的。
4.依据上述3的方法，其中，所述4个核苷酸结合的保守性被应用下列引物进行的RFLP分析所证实：
SEQ ID NO：11和12的一对引物，证实第124,353位的C和124,541的G；
SEQ ID NO：13和14的一对引物，证实第123,635位的G；
SEQ ID NO：15和16的一对引物，证实第122,645位的G。
5.依据上述1到4的方法，该方法进一步包括证实水痘疫苗病毒样品的基因组DNA中下列49个核昔酸是保守的而没有发生突变：
第560位的C，第703位的Y，第763位的Y，第2,515位的Y，第10,900位的Y，第12,779位的Y，第19,431位的Y，第26,125位的G，第31,732位的Y，第38,036位的Y，第39,227位的K，第58,595位的R，第59,287位的R，第64,067位的R，第71,252位的Y，第82,225位的R，第84,091位的R，第87,280位的R，第87,306位的Y，第89,734位的R，第90,535位的R，第94,167位的C，第97,748位的R，第97,796位的Y，第101,089位的R，第105,169位的R，第105,310位的R，第105,705位的C，第106,710位的R，第107,136位的C，第107,599位的R，第107,797位的R，第108,111位的C，第108,838位的R，第109,137位的R，第109,200位的R，第111,650位的R，第118,247位的Y，第120,697位的Y，第120,760位的Y，第121,059位的Y，第121,786位的G，第122,100位的Y，第122,298位的Y，第122,761位的G，第123,187位的Y，第124,192位的G，第124,587位的Y和第124,728位的Y，
其中，核苷酸编号与SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的，
R代表A或G，
Y代表C或T，和
K代表G或T。
6.依据上述5的方法，其中，在49个核苷酸中第560位的C、第26,125位的G、第94,167位的C、第105,705位的C、第107,136位的C、第108,111位的C、第121,786位的G、第122,761位的G和124,192位的G的保守性被应用下列引物进行的RFLP分析所证实：
SEQ ID NO：3和4的一对引物，证实第560位的C；
SEQ ID NO：7和8的一对引物，证实第26,125位的G；
SEQ ID NO：9和10的一对引物，证实第94,167位的C；
SEQ ID NO：13和14的一对引物，证实第105,705位的C和第124,192位的G；
SEQ ID NO：15和16的一对引物，证实第107,136位的C和第122,761位的G；
SEQ ID NO：17和18的一对引物，证实第108,111位的C和第121,786位的G。
7.依据上述1到6任何一项的方法，该方法进一步包括证实水痘疫苗病毒样品的基因组DNA的两个复制起始点的缺失突变，
其中，两个复制起始点是对应于SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的有义链的第110,087位到第110,350位核苷酸的区域和对应于Dumas株的反义链的基因组DNA的第119,547位到第119,810位核苷酸的区域，和
其中，缺失突变发生在每一个具有从5’端到3’端方向排列的ATATATATA的核苷酸序列的片断，这些片断是对应于Dumas株的基因组DNA的有义链的第110,219位到第110,227位核苷酸的一个片断和对应于Dumas株的基因组DNA的反义链的第119,670位到第119,678位核苷酸的一个片断。
8.依据上述1到7任何一项的方法，该方法进一步包括证实水痘疫苗病毒样品的基因组DNA的一个完整R1区的重复序列是一个具有从5’端到3’端方向排列的abbabba’bbb’abababx的核苷酸序列，
其中，
a代表核苷酸序列GGACGCGATCGACGACGA；
a’代表核苷酸序列GGACGCGATTGACGACGA；
b代表核苷酸序列GGGAGAGGCGGAGGA；
b’代表核苷酸序列GGACGCGGCGGAGGA；和
x代表核苷酸序列GGA，
其中完整R1区域是对应于SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的第13,937位到第14,242位核苷酸的区域。
9.依据上述1到8任何一项的方法，该方法进一步包括证实水痘疫苗病毒样品的基因组DNA的两个完整R4区中的每一个的重复序列是一个具有从5’端到3’端方向排列的aaaaaaaaaaaax的核苷酸序列，
其中，
a代表核苷酸序列CCCCGCCGATGGGGAGGGGGCGCGGTA；和
x代表核苷酸序列CCCCGCCGATG，
其中两个完整R4区域是对应于SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的有义链的第109,762位到第109,907位核苷酸的一个区域和对应于Dumas株的基因组DNA的反义链的第119,990位到第120,135位核苷酸的一个区域。
10.由上述1到9任何一项的方法进行质量控制的减毒水痘活疫苗。
11.由上述1到9任何一项的方法中所使用的一个方法鉴定的一种能够作为减毒水痘疫苗病毒发挥功能的病毒株。
本发明详细描述如下。
在完成本发明的方法的研究过程中，本发明人第一次确定了减毒Oka株的基因组DNA的全部核苷酸序列(以保存号V-795于1975年3月14日保存在ATCC(美国典藏中心；10801 University Boulevard，Manassas，VA 20110-2209，美国))。此序列示于SEQ ID NO：2。进一步，应用确定减毒Oka株的全基因组DNA序列，本发明人在Dumas株、亲本Oka株和减毒Oka株的全部基因组DNA中进行了同源搜索。结果，本发明人公开了减毒Oka株的核苷酸突变(即减毒Oka株的核苷酸在对应位点不同于Dumas株和/或亲本Oka株的)，示于下面表1。本发明人进一步分析了核苷酸突变，并鉴定了同义替换(没有由核苷酸突变引起的氨基酸置换)和非同义替换(核苷酸突变引起氨基酸置换)；在非编码区的突变(ncr突变)；终止密码子突变(赭石/琥珀突变)；重复的数目、重复序列的序列大小和重复的次序；和在复制起始点的突变(反向重复序列，参见图1)。如下面将要详述的，由本发明公开的减毒Oka株的突变对于把减毒Oka株从其他水痘病毒株中分辨开来是有用的，尤其是从烈性株中，因而，这些突变可以用来进行减毒水痘活疫苗的质量控制。
在表1所示的减毒Oka株的核苷酸突变中，重要的突变显示XXY型或XX(X/Y)型。显示XXY型的突变是亲本Oka株的核苷酸与Dumas株(即两个核苷酸都是“X”)相应的核苷酸相同的突变，但减毒Oka株的相应核苷酸却是突变的核苷酸(即核苷酸突变为“Y”)。这样一个突变对减毒Oka株来说是独特的。表现XX(X/Y)型的突变是亲本Oka株的核苷酸与Dumas株(即两个核苷酸都是“X”)相应的核苷酸相同的突变，但减毒Oka株的相应核苷酸却是与Dumas株相同的核苷酸和突变的核苷酸的混合物(即相同的核苷酸“X”和突变的核苷酸“Y”的混合物)。在减毒的Oka株的基因组中，有18个核苷酸突变表现XXY型和40个核苷酸突变显示XX(X/Y)型。在总共58个核苷酸突变中，发现有49个核苷酸突变处于编码区，8个核苷酸突变处于非编码区，一个核苷酸突变处于终止密码子中。进一步，在编码区的49个核苷酸突变中，29个核苷酸突变是非同义替换，20个核苷酸突变是同义替换。进一步详细的分析揭示出，在表现XXY型的18个核苷酸突变中，9个核苷酸突变是非同义替换，8个核苷酸突变是同义替换，还发现一个核苷酸突变位于非编码区。下列表现XXY型且是非同义替换的核苷酸突变对于减毒Oka株是独特的：基因6的第5,745位的G；基因62的第105,356位的C、第105,544位的G、第106,262位的C和第107,252位的C；和基因71的第122,645位的G、第123,635位的G、124,353位的C和第124,541位的G。这些减毒Oka株的独特的核苷酸被认为与水痘病毒的减毒和安全性密切相关，因此，这些核苷酸是非常重要的。在上述的9个核苷酸中，发现4个核苷酸位于基因62中，4个核苷酸位于基因71中。因为基因62和基因71包含于反向重复序列中(见图1)，在本发明中，减毒水痘活疫苗的质量控制通过以下方式进行：把水痘疫苗病毒样品的基因组DNA进行序列分析，并证实上述基因6的一个核苷酸和基因62的4个核苷酸是保守的，而没有发生突变。为提高质量控制的准确性，优选样品病毒被进一步证实上述基因71的4个核苷酸是保守的而没有发生突变。
在本发明中，进一步优选证实水痘疫苗病毒样品中对于减毒Oka株独特的所有58个核苷酸是保守的而没有突变。特别地，与表现XXY型和是非同义替换的上述减毒Oka株的独特核苷酸一起，本发明中证实了下列49个核苷酸是保守的而没有发生突变：
第560位的C、第703位的Y、第763位的Y、第2,515位的Y、第10,900位的Y、第12,779位的Y、第19,431位的Y、第26,125位的G、第31,732位的Y、第38,036位的Y、第39,227位的K、第58,595位的R、第59,287位的R、第64,067位的R、第71,252位的Y、第82,225位的R、第84,091位的R、第87,280位的R、第87,306位的Y、第89,734位的R、第90,535位的R、第94,167位的C、第97,748位的R、第97,796位的Y、第101,089位的R、第105,169位的R、第105,310位的R、第105,705位的C、第106,710位的R、第107,136位的C、第107,599位的R、第107,797位的R、第108,111位的C、第108,838位的R、第109,137位的R、第109,200位的R、第111,650位的R、第118,247位的Y、第120,697位的Y、第120,760位的Y、第121,059位的Y、第121,786位的G、第122,100位的Y、第122,298位的Y、第122,761位的G、第123,187位的Y、第124,192位的G、第124,587位的Y和第124,728位的Y，
其中，R代表A或G，Y代表C或T，和K代表G或T。
除了上述的58个核苷酸突变外，通过在Dumas株、亲本Oka株和减毒Oka株的全部基因组DNA中进行同源搜索，发现减毒Oka株的下列独特突变：在复制起始点处的一个缺失突变、在基因11的重复区R1中的一个突变和在非编码区的重复区R4的一个突变。
在水痘病毒基因组中，在包含于反向重复序列中有两个复制起始点(见图1)。复制起始点是一个对应于Dumas株的基因组DNA的有义链的第110,087位到110,350位核苷酸的区域和对应于Dumas株的基因组DNA的反义链的第119,547位到119,810位核苷酸的区域。有义链的核苷酸序列示于表4。正如在表4中所显明的，减毒Oka株的复制起始点的缺失发生在每个在5’端到3’端方向具有TATATATATATATA序列的核苷酸的片断中，这些片断是对应于有义链的第110,214位到110,227位核苷酸的片断和对应于反义链的第119,670位到119,683位核苷酸的区域。在本发明中，优选此缺失的存在被进一步证实。特别地，此缺失可由确定每个含有对应于有义链的第110,219位到110,227位核苷酸和反义链的第119,670位到119,678位的核苷酸的核苷酸序列ATATATATA的片断的存在与否被证实。
基因11的重复区域R1是对应于Dumas株的基因组DNA的第13,937位到第14,242位核苷酸的区域，R1区域的核苷酸序列示于表5。如表5所显示的，减毒Oka株的R1区域的核苷酸序列不仅不同于Dumas株，也不同于亲本Oka株。因此，为了疫苗的质量控制，优选证实水痘疫苗病毒样品的R1区域与减毒Oka株的R1区域是相同的。特别地，证实水痘疫苗病毒样品的基因组DNA的一个完整R1区域的重复序列是以从5’端到3’端方向排列的abbabba’bbb’abababx的核苷酸序列(其中，a代表GGACGCGATCGATTGACGACGA的核苷酸序列；a’代表GGACGCGATTGACGACGA的核苷酸序列 b代表GGGAGAGGCGGAGGA 的核苷酸序列；b’代表GGACGCGGCGGAGGA的核苷酸序列；和x代表GGA的核苷酸序列)。
在水痘病毒基因组中，在非编码区发现在反向重复序列中含有的两个重复区域R4(见图1)。R4区域是对应于Dumas株的基因组DNA的有义链的第109,762位到109,907位核苷酸的一个区域和对应于Dumas株的基因组DNA的反义链的第119,990位到120,135位核苷酸的一个区域。从5’端到3’端方向排列的R4区域的核苷酸序列示于表7。如表7所示，减毒Oka株的R4区域的重复序列不仅不同于Dumas株，也不同于亲本Oka株。因此，为了疫苗的质量控制，优选证实水痘疫苗病毒样品的R4区域与减毒Oka株的R4区域是相同的。特别地，证实水痘疫苗病毒样品的基因组DNA的两个完整R4区域中的每一个的重复序列是以从5’端到3’端方向排列的aaaaaaaaaaaax的核苷酸序列(其中，a代表CCCCGCCGATGGGGAGGGGGCGCGGTA的核苷酸序列；和x代表CCCCGCCGATG的核苷酸序列)。
另外，发现在表6中所示的突变位于基因22的重复区R3中。然而，如表6中所示，在减毒Oka株和亲本Oka株的R3区域的重复序列中有很大的多样性。
本发明的方法基于上述的对于减毒Oka株是独特的核苷酸突变而完成。因而，本发明为质量控制而应用的方法不仅可应用于减毒水痘活疫苗的质量控制(即确定一种疫苗的种子病毒、作为疫苗的原材料的减毒水痘病毒或一种活疫苗是否被突变了)，而且也可应用于能够作为减毒水痘病毒(可被用作水痘疫苗活性成份的病毒)的病毒株的鉴定和烈性株(亲本Oka株或自然野生型株)的分析。并且，本发明的方法提供了用来描述种痘的效果和研究水痘和带状疱疹的流行病学的准确和先进的技术，也提供了阻止水痘和带状疱疹的准确测量方法。
下面详细介绍进行本发明质量控制的具体方法。
水痘病毒样品的基因组DNA制备：在本发明的方法中，用来作为减毒水痘活疫苗的活性成份的病毒悬浮液或大体积疫苗溶液、通过繁殖所要的VZV得到的病毒悬浮液和从自然感染水痘的病人中得到的泡状液体和类似物，可以作为水痘病毒样品。可用常规的方法直接从样品病毒中提取和纯化基因组DNA。或者，可用VZV感染细胞作为样品病毒，可用常规的方法从感染的细胞中提取和纯化病毒的基因组DNA(关于提取和纯化DNA的方法，可参见《分子生物学操作规程》，第一卷，第二章，2.0.1-2.6.12，John Wiley & Sons，Inc.，1987-2000(散叶***))。为繁殖VZV，可以用WI-38细胞和MRC-5细胞。优选泡状液体用作分离、繁殖和制备新鲜野生型株或流行病株的材料，取自自然感染、出痘三天的病人。
制备PCR引物：VZV基因组DNA的目标核苷酸序列可用PCR方法扩增。首先，用DNA合成仪制备含有对应于区域的有义和反义序列的5’端的大约15到30个核苷酸相邻序列的寡聚核苷酸链。制备的寡聚核苷酸链用作引物对。减毒Oka株的全基因组DNA序列示于SEQ ID NO：2，并且当设计PCR引物时，可参考在本说明书“在先技术”下提到的专利文献(美国专利第6,093,535号和国际申请公开WO00/50603)。
确定PCR产物的核苷酸序列：从节约实验的劳动的角度来说，优选用DNA直接测序的方法分析PCR产物而不用制备基因组DNA文库(此方法在《分子生物学操作规程》中有描述，第3卷，第15章，15.2.1-15.2.11，同上)。此方法中，可利用传统的方法进行核苷酸序列的测序，例如，应用环测序试剂盒(Cycle Sequence Kit)(由日本TAKARASHUZO公司制备和销售)和DNA测序试剂盒(由美国Perkin ElmerApplied Biosystems公司制造和销售)的双脱氧法。
DNA序列的同源搜索：可以应用商业可得的用于基因分析的计算机软件进行DNA序列的同源搜索。例如，可以应用GENETYX-WIN(3.1版本)(由日本软件开发公司制造和销售)、DNASIS(3.7版本)(由日本日立软件工程公司制造和销售)、FASTA(http：//www.ddjb.nig.ac.jp)和BLAST(http：//www.ncbi.nlm.nih.gov)。一个水痘疫苗病毒样品是否含有本发明公开的减毒水痘Oka株特定核苷酸序列，可通过同源搜索来确定。
通过RFLP分析证实核苷酸突变：在确定样品病毒的基因组DNA的核苷酸序列(全部或部分)之后，除进行同源搜索外，可通过RFLP(限制片断长度多态性)分析以证实减毒Oka株的独特核苷酸是保守的而没有受到突变。特别地，用DNA合成仪制备含有对应于目标区域的有义和反义序列的5’端的大约15到30个核苷酸相邻序列的寡聚核苷酸链。制备的寡聚核苷酸链用作PCR引物对。一对PCR引物同时用来扩增区域，用作样品DNA。因此，得到的样品DNA用一种限制酶消化，并进行凝胶电泳。通过检测DNA片断大小的差别确定存在的突变，比同源搜索更容易实施的RFLP分析优选用于本发明的质量控制的方法。至于减毒Oka株的表现XXY型和非同义替换(第5,745位的G、第105,356位的C、第105,544位的G、第106,262位的C、第107,252位的C、第122,645位的G、第123,635位的G、第124,353位的C、第124,541位的G)的9个特别的核苷酸突变，和减毒Oka株其余49个核苷酸突变中的第560位的C、第26,125位的G、第94,167位的C、第105,705位的C、第107,136位的C、第108,111位的C、第121,786位的G、第122,761位的G和第124,192位的G，突变存在与否可应用表8(SEQ ID NO：3到18)中所示的8对引物通过RFLP分析而确定。通过应用表8中所示的PCR引物得到的PCR产物的限制位点和限制片断大小一起被总结在表9。例如，基因6的突变(在减毒Oka株的基因6中发现的第5,745位核苷酸)可通过限制酶
Alu I位点的存在与否被检测出来。特别地，应用表8中所示的引物01-N12和01-R13扩增对应于水痘疫苗病毒样品的基因组DNA的第5,372位到第6,134位核苷酸的763bp的DNA片断。扩增的片断用
Alu I消化，并走琼脂糖凝胶电泳。在烈性株的情况下，PCR产物被切成三个片断(170bp、205bp和388bp)。另一方面，减毒Oka株的PCR产物被切成两个片断(170bp和593bp)。因此，可通过限制片断类型来确定一个水痘疫苗病毒样品是否可作为疫苗株。
在本发明中，表现XXY类型和是非同义替换的减毒Oka株的9个核苷酸突变优选应用下列引物通过RFLP分析证实：证实第5,745位的G的SEQ ID NO：5和6的引物对；证实第105,356位的C、第105,544位的G、第124,353位的C、第124,541位的G的SEQ ID NO：11和12的引物对；证实第106,262位的C和地123,635的G的SEQID NO：13和14的引物对；证实第107,252位的C和第122,645位的G的SEQ ID NO：15和16的引物对。因为基因62和基因71是反向重复序列的(见图1)，减毒水痘活疫苗的质量控制可通过RFLP分析证实至少5个核苷酸是保守的而进行(即基因6的一个核苷酸和基因62的4个核苷酸)。
如上所述，减毒Oka株(SEQ ID NO：2)的全基因组DNA序列和减毒Oka株独特的核苷酸突变由本发明人第一次公开。因为减毒Oka株独特的核苷酸突变被认为对于水痘病毒的减毒非常重要，可以通过对烈性株(例如一个野生型VZV株或一个流行病性株)进行核苷酸替换或通过在烈性株中诱导氨基酸突变的方法构建减毒株。在Proc.Natl.Acad.Sci.，USA，90(15)，7376-7380，1998中描述的方法可用作一种遗传工程技术以诱导核苷酸或氨基酸突变。特别地，减毒Oka株独特的58个核苷酸突变可以作为诱导烈性株突变的一种指标，并且9个非同义核苷酸替换特别有用。还有，考虑到基因62和基因71包含在反向重复序列中的事实(见图1)，在上述的核苷酸替换中，至少5种核苷酸突变(即在基因6中发现的突变和在基因62或基因71中发现的突变)被认为是非常重要的。
实施本发明的最佳模式
在下面，本发明将通过引用如下的实施例得到更详细的描述，但不应该认为它们限制了本发明的范围。
实施例1
减毒Oka株(减毒疫苗株)和它的亲本株(亲本Oka株；没有减毒的烈性株)各自接种到MRC-5细胞中得到感染细胞。减毒Oka株和亲本Oka株的基因组DNA分别从感染细胞中用酚和氯仿/异戊醇提取，用乙醇沉淀纯化，并得到DNA。用得到的DNA作为模板和88个合成引物(44对引物)制备覆盖每个病毒株全部基因组的PCR产物。然后，利用520个合成引物和DNA测序试剂盒(由美国Perkin ElmerApplied Biosystems公司制造和销售)应用直接的DNA测序方法，确定PCR产物的核苷酸序列。用SEQ ID NO：1中所示的Dumas株(烈性株)全部核苷酸序列作为标准，对得到的减毒Oka株和亲本Oka株的全部基因组DNA序列进行同源性检查。用DNASIS(3.7版本)(由日本日立软件工程公司制造和销售)进行同源搜索。同源搜索中表现突出的减毒Oka株的特征总结于表1到7。
通过比较三个水痘株(Dumas株、亲本Oka株和减毒Oka株)的序列，检测到的核苷酸突变列于表1。特别地，对于每一个核苷酸突变，描述了核苷酸编号、基因编号、突变核苷酸和由核苷酸突变带来的氨基酸突变。在表1中，Y代表一个嘧啶碱基(即C或T)，R代表一个嘌呤碱基(即A或G)，K代表G或T，(ncr)代表非编码区，括号中的字母(例如“(W)”)是氨基酸的单字母缩写，(och)代表赭石密码子，(amb)代表琥珀密码子，(W/R)代表色氨酸(W)或精氨酸(R)，(del)代表缺失。
在表1所列的突变中，通过在减毒Oka株和亲本Oka株之间进行序列对比检测到的突变列于表2。特别地，对于每一个核苷酸突变，描述了核苷酸编号、基因编号、突变核苷酸和核苷酸突变带来的氨基酸突变。在表2中，X/Y代表X或Y，由核苷酸编码的氨基酸的三字母缩写被示于核苷酸后的括号内(当一个核苷酸位于非编码区时，核苷酸后面跟以“(ncr)”)。在表2中应用的其他缩写都与在表1中应用的相同。
根据突变类型，把在表1和表2中描述的核苷酸突变总结于表3。突变类型和其丰度与突变类型的详细情况被列于一起，即突变的特别类型(终止密码子(och/amb)突变、同义或非同义替换、缺失(或添加))和每一个突变类型的丰度。
在表1到3中的发现在下面详细解释。
在通过比较减毒Oka株和亲本Oka株的全部基因组DNA序列确定的主要核苷酸和氨基酸的突变中，发现在下列(a)到(f)项中描述的突变对于减毒水痘活疫苗的质量控制是特别的有用和重要。
(a)减毒Oka株有58个重要核苷酸突变，即18个表现XXY型的核苷酸突变和40个表现XX(X/Y)型的核苷酸突变。
(b)在上述58个突变中，发现49个突变位于编码区，8个突变位于非编码区，1个突变在终止密码子中。
(c)在编码区发现的49个突变中，29个突变是非同义替换，20个突变是同义替换。
(d)在表现XXY型的18个突变中，9个突变是非同义替换，8个突变是同义替换，一个突变被发现在终止密码子中。
(e)上述表现为非同义替换的9个XXY型突变(即基因6的第5,745位核苷酸的G；基因62的第105,356位核苷酸的C、第105,544位核苷酸的G、第106,262位核苷酸的C和第107,252位核苷酸的C；基因71的第122,645位核苷酸的G、第123,635位核苷酸的G、第124,353位核苷酸的C和第124,541位核苷酸的G)，可被用于能够作为活疫苗的活性成份的病毒株的减毒或安全性的标记物。因此，这些核苷酸突变对于疫苗的质量控制是有用的和重要的。应该注意到，基因62和基因71被包含在反向重复序列中(见图1)。
(f)疫苗株的40个核苷酸表现XX(X/Y)型(即在这种突变类型中，病毒株是含有核苷酸X的病毒和含有核苷酸Y的病毒的混合物)。当减毒Oka株实验性再培养时(即病毒被传代5次、10次、17次等)，所有XX(X/Y)型的核苷酸，除了第106,710位核苷酸，表现出跟随趋势。核苷酸Y的检测频率随传代数目(即核苷酸从X/Y改变为Y)而增加，核苷酸突变类型转变为XXY型。换句话说，X对Y的比率(X/Y)随传代数目而降低。基于上述现象，可认为在种子批次***中应用的种子病毒的传代数目可通过测量X/Y值被估计出来。应该注意到，在上述突变中，20个突变转变为非同义替换。对于其余的突变，12个突变是同义替换，1个突变被发现位于终止密码子中(特别地，一个赭石密码子/琥珀密码子的混合物转变为琥珀突变)，7个突变被发现位于非编码区。
表1
| 核苷酸编号 | 基因编号 | Dumas株 | 亲本Oka株 | 减毒Oka株 |
| 13117236262560 | 5’/基因15’/基因15’/基因15’/基因15’/基因15’/基因1 | A(ncr)G(ncr)C(ncr)A(ncr)C(ncr)T(ncr) | G(ncr)C(ncr)delG(ncr)T(ncr)T(ncr) | G(ncr)C(ncr)delG(ncr)T(ncr)C(ncr) |
| 685703 | 基因1基因1 | G(N)T(Q) | A(N)T(Q) | A(N)Y(Q) |
| 763 | 基因1 | T(P) | T(P) | Y(P) |
| 789790-12515 | 基因1基因1基因3/4 | T(T)TT(Q)T(ncr) | C(A)CC(R)T(ncr) | C(A)CC(R)Y(ncr) |
| 376442585745 | 基因4基因5基因6 | A(T)C(K)A(S) | G(T)T(K)A(S) | G(T)T(K)G(P) |
| 68537091775394601007910900 | 基因6基因6基因6基因7/8基因8基因9A | G(H)C(G)C(P)T(ncr)G(P)T(W) | T(Q)A(V)T(P)C(ncr)A(S)T(W) | T(Q)A(V)T(P)C(ncr)A(S)Y(W/R) |
| 118901190612188122841228512779 | 基因9基因9基因10基因10基因10基因10 | T(S)A(T)C(P)T(F)T(F)C(A) | G(S)G(A)A(H)C(S)C(S)C(A) | G(S)G(A)A(H)C(S)C(S)Y(A/V) |
| 1317313407143901740417834180821846719431 | 基因10基因10/11基因11基因12基因12基因12基因13基因14 | T(G)G(ncr)T(C)C(V)C(L)C(T)G(K)T(o) | G(G)A(ncr)C(C)T(V)T(L)T(T)A(K)T(o) | G(G)A(ncr)C(C)T(V)T(L)T(T)A(K)Y(o/a) |
| 19719206562068421371217342231122504227942329424515-724578246542506726125 | 基因14基因14基因14基因15基因15基因15基因15/16基因16基因16基因17基因17基因17基因17基因18 | A(I)T(Y)T(T)G(L)G(R)G(S)A(ncr)A(M)A(F)TCA(S)A(T)C(T)G(V)A(N) | G(I)A(F)C(A)A(L)T(R)A(S)G(ncr)G(T)G(F)delG(A)T(M)A(I)A(N) | G(I)A(F)C(A)A(L)T(R)A(S)G(ncr)G(T)G(F)delG(A)T(M)A(I)G(N) |
| 275232920131732 | 基因19基因20基因21 | A(H)T(G)C(T) | G(H)G(G)C(T) | G(H)G(G)Y(T/I) |
表1(续)
| 核苷酸编号 | 基因编号 | Dumas株 | 亲本Oka株 | 减毒Oka株 |
| 3227433722337253372835543376493790238036 | 基因21基因21基因21基因21基因22基因22基因22基因22 | A(T)T(H)T(D)T(N)T(V)A(L)A(I)T(T) | G(A)C(H)C(D)C(N)C(V)G(L)G(V)T(T) | G(A)C(H)C(D)C(N)C(V)G(L)G(V)Y(T) |
| 38055380813817738714387173902339227 | 基因22基因22基因22基因22基因22基因22基因22 | T(V)A(P)G(E)G(T)C(A)A(R)T(P) | C(H)C(P)A(E)T(T)T(A)G(R)T(P) | C(H)C(P)A(E)T(T)T(A)G(R)K(P) |
| 392633939439530403884105741452416184176442069421764224242401-34247643262448354716247940480504682549535500815116852917534825393854359-735456254564558205722457301573975a595 | 基因22基因22基因22基因22基因22基因22基因22基因22基因22基因22基因22基因22/23基因23基因24基因26基因28基因28基因28基因28基因28基因28基因29基因29基因29基因29基因29基因29/30基因29/30基因30基因31基因31基因31基因31 | G(Q)G(R)A(V)A(Q)T(P)G(R)C(T)G(S)C(Q)C(R)A(A)AAA(ncr)T(S)T(I)C(C)A(C)C(L)T(S)G(T)G(L)C(G)C(S)A(Q)A(I)G(A)AACATTTC(NISGS) AGGGTCAT(ncr)T(ncr)A(P)A(T)A(A)G(A)A(I) | A(Q)A(H)G(V)G(Q)C(P)A(Q)T(T)A(N)G(E)T(R)C(A)delG(S)C(V)T(C)G(R)T(L)C(G)A(T)A(L)A(C)T(S)G(Q)C(L)A(T)deldel(ncr)C(ncr)G(P)C(P)C(A)T(A)A(I) | A(Q)A(H)G(V)G(Q)C(P)A(Q)T(T)A(N)G(E)T(R)C(A)delG(S)C(V)T(C)G(R)T(L)C(G)A(T)A(L)A(C)T(S)G(Q)C(L)A(T)deldel(ncr)C(ncr)G(P)C(P)C(A)T(A)R(I/V) |
| 59287 | 基因31 | A(P) | A(P) | R(P) |
| 59760-160276-860279 | 基因31/32基因32/33基因32/33 | del(ncr)AAA(ncr)A(ncr) | G(ncr)delC(ncr) | G(ncr)delC(ncr) |
表1(续)
| 核苷酸编号 | 基因编号 | Dumas株 | 亲本Oka株 | 减毒Oka株 |
| 604056078161018-961201-264067 | 基因33基因33基因33基因33基因35 | C(A)T(Y)GG(P)TT(N)A(A) | A(A)G(S)AA(F)CC(G)A(A) | A(A)G(S)AA(F)CC(G)R(A) |
| 6413664259643756498965669666466687968172693496975671252 | 基因35基因35基因35基因36基因36基因37基因37基因37基因38基因38基因39 | A(C)T(P)T(M)C(A)C(S)G(L)C(P)G(R)A(T)T(S)T(M) | G(C)C(P)C(V)T(A)T(L)T(L)T(L)A(K)G(T)C(G)T(M) | G(C)C(P)C(V)T(A)T(L)T(L)T(L)A(K)G(T)C(G)Y(M/T) |
| 7299773993765307814480244808408118782225 | 基因40基因40基因41基因42/43基因43/44基因44基因44基因45 | C(V)T(T)C(V)T(ncr)G(ncr)A(N)C(A)A(P) | T(V)C(T)T(V)delT(ncr)G(D)T(A)A(P) | T(V)C(T)T(V)delT(ncr)G(D)T(A)R(P) |
| 84091 | 基因47 | G(E) | G(E) | R(E) |
| 846168498385563817086484-938655687280 | 基因47基因48基因48基因48基因49/50基因49/50基因50 | A(T)G(R)C(D)C(Q)CCTGATAA(ncr) ACT(ncr)A(C) | G(T)A(H)T(D)A(K)del(ncr)G(ncr)A(C) | G(T)A(H)T(D)A(K)del(ncr)G(ncr)R(C) |
| 87306 | 基因50 | T(S) | T(S) | Y(S/G) |
| 878418847789734 | 基因50基因51基因51 | C(S)G(S)A(T) | T(S)T(S)A(T) | T(S)T(S)R(T) |
| 8990590202902179039290535 | 基因51基因51基因51基因51/52基因52 | T(T)G(Q)T(S)G(ncr)A(I) | C(T)T(H)C(S)A(ncr)A(I) | C(T)T(H)C(S)A(ncr)R(I/V) |
| 911919202692092923759299994167 | 基因52基因52基因52基因52基因53基因54 | C(G)A(T)A(T)A(H)T(V)T(L) | T(G)G(A)G(A)G(R)C(V)T(L) | T(G)G(A)G(A)G(R)C(V)C(L) |
| 9463294641952419554695601 | 基因54基因54基因54基因54基因54 | A(V)A(T)T(G)G(L)T(E) | G(V)T(T)C(G)A(L)G(D) | G(V)T(T)C(G)A(L)G(D) |
表1(续)
| 核苷酸编号 | 基因编号 | Dumas株 | 亲本Oka株 | 减毒Oka株 |
| 971419759197748 | 基因55基因55基因55 | T(L)C(I)G(A) | C(L)T(I)G(A) | C(L)T(I)R(A/T) |
| 97796 | 基因55 | T(C) | T(C) | Y(C/R) |
| 98437987659880799226-8994219970999981100114100151100283101089 | 基因55基因56基因56基因56基因57基因57基因58基因58基因58基因58/59基因59 | T(G)A(V)A(T)CTT(S)T(H)A(Y)C(V)T(K)T(N)A(ncr)A(L) | C(G)C(V)C(T)delG(P)G(Y)T(K)A(N)G(T)G(ncr)A(L) | C(G)C(V)C(T)delG(P)G(Y)T(K)A(N)G(T)G(ncr)R(L/P) |
| 101331101623-4101886101991102192102203102309102351102458102601103043104898105009-10105012105015105017105054105071105151-2105169 | 基因60基因60基因60/61基因60/61基因60/61基因60/61基因60/61基因60/61基因60/61基因60/61基因60/61基因61/62基因61/62基因61/62基因61/62基因61/62基因61/62基因61/62基因61/62基因61/62 | C(A)delT(ncr)C(ncr)G(ncr)A(ncr)C(ncr)A(ncr)A(ncr)T(ncr)T(ncr)A(ncr)delT(ncr)T(ncr)T(ncr)G(ncr)G(ncr)del(ncr)A(ncr) | T(T)ATC(H)C(ncr)T(ncr)A(ncr)G(ncr)A(ncr)C(ncr)G(ncr)G(ncr)C(ncr)G(ncr)G(ncr)C(ncr)C(ncr)C(ncr)deldelACAA(ncr)A(ncr) | T(T)ATC(H)C(ncr)T(ncr)A(ncr)G(ncr)A(ncr)C(ncr)G(ncr)G(ncr)C(ncr)G(ncr)G(ncr)C(ncr)C(ncr)C(ncr)deldelACAA(ncr)R(ncr) |
| 105310 | 基因62 | A(L) | A(L) | R(L/S) |
| 105312105356 | 基因62基因62 | A(G)T(I) | G(G)T(I) | G(G)C(V) |
| 105451105512105544 | 基因62基因62基因62 | A(L)A(S)A(V) | G(P)C(A)A(V) | G(P)C(A)G(A) |
| 105705 | 基因62 | T(A) | T(A) | C(A) |
| 106262 | 基因62 | T(R) | T(R) | C(G) |
| 106710 | 基因62 | A(A) | A(A) | R(A) |
| 107136 | 基因62 | T(A) | T(A) | C(A) |
| 107165107252 | 基因62基因62 | C(A)T(S) | T(T)T(S) | T(T)C(G) |
| 107307107599 | 基因62基因62 | T(R)A(V) | C(R)A(V) | C(R)R(V/A) |
| 107607107715107797 | 基因62基因62基因62 | C(T)T(A)A(L) | A(T)C(A)A(L) | A(T)C(A)R(L/P) |
表1(续)
| 核苷酸编号 | 基因编号 | Dumas株 | 亲本Oka株 | 减毒Oka株 |
| 108111 | 基因62 | T(P) | T(P) | C(P) |
| 108747108838 | 基因62基因62 | A(L)A(M) | G(L)A(M) | G(L)R(M/T) |
| 108951109044109137 | 基因62基因62基因62/63 | G(H)C(A)A(ncr) | A(H)G(A)A(ncr) | A(H)G(A)R(ncr) |
| 109200 | 基因62/63 | A(ncr) | A(ncr) | R(ncr) |
| 109654109696-7110003110058110112110378110386111312111650 | 基因62/63基因62/63基因62/63基因62/63基因62/63基因62/63基因62/63基因63基因64 | G(ncr)delG(ncr)G(ncr)G(ncr)G(ncr)C(ncr)A(T)A(Q) | T(ncr)CAT(ncr)A(ncr)delA(ncr)deldelG(T)A(Q) | T(ncr)CAT(ncr)A(ncr)delA(ncr)deldelG(T)R(Q/R) |
| 112093112137112198114140115041115926117699117760117804118247 | 基因64基因64/65基因64/65基因66基因67基因68基因68/69基因68/69基因69基因69 | T(Y)A(ncr)G(ncr)A(S)G(P)C(T)C(ncr)T(ncr)A(Y)T(Q) | C(H)delA(ncr)G(S)A(P)T(I)T(ncr)delG(H)T(Q) | C(H)delA(ncr)G(S)A(P)T(I)T(ncr)delG(H)Y(Q/R) |
| 118585119511119519119785119839119894120200-1120243120697 | 基因70基因70/71基因70/71基因70/71基因70/71基因70/71基因70/71基因70/71基因70/71 | T(T)G(ncr)C(ncr)C(ncr)C(ncr)C(ncr)delC(ncr)T(ncr) | C(T)deldelT(ncr)delT(ncr)ATG(ncr)A(ncr)T(ncr) | C(T)deldelT(ncr)delT(ncr)ATG(ncr)A(ncr)Y(ncr) |
| 120760 | gene70/71 | T(ncr) | T(ncr) | Y(ncr) |
| 120853120946121059 | 基因71基因71基因71 | G(A)C(H)T(M) | C(A)T(H)T(M) | C(A)T(H)Y(M/T) |
| 121150121786 | 基因71基因71 | T(L)A(P) | C(L)A(P) | C(L)G(P) |
| 122100 | 基因71 | T(L) | T(L) | Y(L/P) |
| 122182122290122298 | 基因71基因71基因71 | A(A)G(T)T(V) | G(A)T(T)T(V) | G(A)T(T)Y(V/A) |
| 122590122645 | 基因71基因71 | A(R)A(S) | G(R)A(S) | G(R)G(G) |
| 122732122761 | 基因71基因71 | G(A)A(A) | A(T)A(A) | A(T)G(A) |
| 123187 | 基因71 | T(A) | T(A) | Y(A) |
| 123635 | 基因71 | A(R) | A(R) | G(G) |
| 124192 | 基因71 | A(A) | A(A) | G(A) |
表1(续)
| 核苷酸编号 | 基因编号 | Dumas株 | 亲本Oka株 | 减毒Oka株 |
| 124353 | gene71 | T(V) | T(V) | C(A) |
| 124385124446124541 | 基因71基因71基因71 | T(S)T(L)A(I) | G(A)C(P)A(I) | G(A)C(P)G(V) |
| 124585124587 | 基因71基因71 | T(G)T(L) | C(G)T(L) | C(G)Y(L/S) |
| 124728 | 基因71/3’ | T(ncr) | T(ncr) | Y(ncr) |
| 124745-6124826124843124880124882 | 基因71/3’基因71/3’基因71/3’基因71/3’基因71/3’ | del(ncr)C(ncr)C(ncr)A(ncr)A(ncr) | TTGT(ncr)deldelG(ncr)G(ncr) | TTGT(ncr)deldelG(ncr)G(ncr) |
表2
基因编号 核苷酸编号 减毒Oka株 亲本Oka株 Dumas株
1 560 C(ncr) T(ncr) T(ncr)
703 T/C(Gln) T(Gln) T(Gln)
763 T/C(Pro) T(Pro) T(Pro)
3-4 2515 T/C(ncr) T(ncr) T(ncr)
6 5745 G(Pro) A(Ser) A(Ser)
9A 10900 T/C(Trp/Arg) T(Trp) T(Trp)
10 12779 C/T(Ala/Val) C(Ala) C(Ala)
14 19431 T/C(och/amb) T(och) T(och)
18 26125 G(Asn) A(Asn) A(Asn)
21 31732 C/T(Thr/Ile) C(Thr) C(Thr)
22 38036 T/C(Thr) T(Thr) T(Thr)
39227 G/T(Pro) T(Pro) T(Pro)
31 58595 A/G(Ile/Val) A(Ile) A(Ile)
59287 A/G(Pro) A(Pro) A(Pro)
35 64067 A/G(Ala) A(Ala) A(Ala)
39 71252 T/C(Met/Thr) T(Met) T(Met)
45 82225 A/G(Pro) A(Pro) A(Pro)
47 84091 A/G(Glu) G(Glu) G(Glu)
50 87280 A/G(Cys) A(Cys) A(Cys)
87306 T/C(Ser/Gly) T(Ser) T(Ser)
51 89734 A/G(Thr) A(Thr) A(Thr)
52 90535 A/G(Ile/Val) A(Ile) A(Ile)
54 94167 C(Leu) T(Leu) T(Leu)
55 97748 G/A(Ala/Thr) G(Ala) G(Ala)
97796 T/C(Cys/Arg) T(Cys) T(Cys)
59 101089 A/G(Leu/Pro) A(Leu) A(Leu)
61-62 105169 A/G(ncr) A(ncr) A(ncr)
62 105310 A/G(Leu/Ser) A(Leu) A(Leu)
105356 C(Val) T(Ile) T(Ile)
105544 G(Ala) A(Val) A(Val)
105705 C(Ala) T(Ala) T(Ala)
106262 C(Gly) T(Arg) T(Arg)
106710 A/G(Ala) A(Ala) A(Ala)
107136 C(Ala) T(Ala) T(Ala)
107252 C(Gly) T(Ser) T(Ser)
107599 A/G(Val/Ala) A(Val) A(Val)
107797 A/G(Leu/Pro) A(Leu) A(Leu)
表2(续)
基因编号 核苷酸编号 减毒Oka株 亲本Oka株 Dumas株
108111 C(Pro) T(Pro) T(Pro)
108838 A/G(Met/Thr) A(Met) A(Met)
62-63 109137 A/G(ncr) A(ncr) A(ncr)
109200 A/G(ncr) A(ncr) A(ncr)
64 111650 A/G(Gln/Arg) A(Gln) A(Gln)
69 118247 T/C(Gln/Arg) T(Gln) T(Gln)
70-71 120697 T/C(ncr) T(ncr) T(ncr)
120760 T/C(ncr) T(ncr) T(ncr)
71 121059 T/C(Met/Thr) T(Met) T(Met)
121786 G(Pro) A(Pro) A(Pro)
122100 T/C(Leu/Pro) T(Leu) T(Leu)
122298 T/C(Val/Ala) T(Val) T(Val)
122645 G(Gly) A(Ser) A(Ser)
122761 G(Ala) A(Ala) A(Ala)
123187 T/C(Ala) T(Ala) T(Ala)
123635 G(Gly) A(Arg) A(Arg)
124192 G(Ala) A(Ala) A(Ala)
124353 C(Ala) T(Val) T(Val)
124541 G(Val) A(Ile) A(Ile)
124587 T/C(Leu/Ser) T(Leu) T(Leu)
71-3’ 124728 T/C(ncr) T(ncr) T(ncr)
ncr：非编码区
X/Y：X或Y
och/amb：赭石密码子或琥珀密码子的终止密码子突变
表3
| 核苷酸突变类型 | Dumas株 | 亲本Oka株 | 减毒Oka株 | 氨基酸替换 | 核苷酸编号 |
| XXX型 | ○ | ○ | ○ | 124,585 | |
| XYY型 | ○ | ● | ● | 189 | |
| 同义非同义ncr | 916236 | ||||
| XXY型 | ○ | ○ | ● | 18 | |
| 同义非同义ncr | 891 | ||||
| XX(X/Y)型 | ○ | ○ | ○/● | 40 | |
| 同义非同义ncroch/amb | 122071 | ||||
| XYX型XYZ型 | ○○ | ●● | ○◆ | 00 | |
| XDD型DXX型 | ○缺失 | 缺失○ | 缺失○ | 5219 |
XXX型：所有三个株在对应于相同的核苷酸位点(即“对应核苷酸编号”)的核苷酸编号处具有相同的核苷酸。
XYY型：只有Dumas株在对应的核苷酸编号处具有不同的核苷酸。
XXY型：只有减毒Oka株在对应的核苷酸编号处具有不同的核苷酸。
XX(X/Y)型：只有减毒Oka株在对应的核苷酸编号处具有核苷酸X/Y(X或Y)。因此，减毒Oka株是XXX和XXY型的混合。例如，位于基因62中表现为XX(X/Y)型的8个突变，当传代数从5倍、10倍和17倍增加时，X对Y的比值(X/Y)迅速降低，并且突变类型转变为XXY型。然而，只有第106,710位核苷酸A/G保持未变，没有从A转变为G。
XYX型：只有亲本Oka株在对应的核苷酸编号处具有不同的核苷酸。
XYZ型：所有三个株在对应的核苷酸编号处具有不同的核苷酸。
XDD型：在对应的核苷酸编号处的核苷酸要么在亲本Oka株和减毒Oka株中缺失(del)，要么只在Dumas株中被添加。
DXX型：在对应的核苷酸编号处的核苷酸要么只在Dumas株中缺失(del)，要么在亲本Oka株和减毒Oka株中被添加。
ncr：非编码区
och/amb：赭石密码子或琥珀密码子的终止密码子突变
表4表示Dumas株、亲本Oka株和减毒Oka株的复制起始点的有义链的核苷酸序列的序列对比。在此表中，“-”代表缺失。
在减毒Oka株中，缺失发生在按5’端到3’端方向排列的核昔酸序列TATATATATATATA的每一个片断上，该片断对应于SEQ IDNO：1的Dumas株基因组DNA有义链的第110,214位到第110,227位核苷酸，以及发生在对应于Dumas株基因组DNA反义链的第119,670位到第119,683位核苷酸的一个片断。因此，考虑到在亲本Oka株和减毒Oka株之间的差别，显然在3’端缺失ATATATATA片断对于疫苗的质量控制是有用的。
表4
110087
D GTACGCCAATCGGATACACTCTTTTGATCT
P GTACGCCAATCGGATACACTCTTTTAATCT
V GTACGCCAATCGGATACACTCTTTTAATCT
110117
D GCATTCGCACTTCCCGTTTTTTCACTGTAT
P GCATTCGCACTTCCCGTTTTTTCACTGTAT
V GCATTCGCACTTCCCGTTTTTTCACTGTAT
110147
D GGGTTTCATTGTTTTGGCATGTGTCCAACC
P GGGTTTCATTGTTTTGGCATGTGTCCAACC
V GGGTTTCATTGTTTTGGCATGTGTCCAACC
110177
D ACCGTTCGCACTTTCTTTCTATATATATAT
P ACCGTTCGCACTTTCTTTCTATATATATAT
V ACCGTTCGCACTTTCTTTCTATATATATAT
110207
D ATATATATATATATATATATAGAGAAAGAG
P ATATATATATATA--------GAGAGAGAG
V ATATATA--------------GAGAGAGAG
110237
D AGAGAG--------------TTTCTTGTTC
P AGAGAGAGAGAGGGAGAGAGTTTCTTGTTC
V AGAGAGAGA--GGGAGAGAGTTTCTTGTTC
110267
D GCGCGTGTTCCCGCGATGTCGCGGTTTTAT
P GCGCGTGTTCCCGCGATGTCGCGGTTTTAT
V GCGCGTGTTCCCGCGATGTCGCGGTTTTAT
110297
D GGGGTGTGGGCGGGCTTTTCACAGAATATA
P GGGGTGTGGGCGGGCTTTTCACAGAATATA
V GGGGTGTGGGCGGGCTTTTCACAGAATATA
110327
D TATATTCCAAATGGAGCGGCAGGCTTTTTA
P TATATTCCAAATGGAGCGGCAGGCTTTTTA
V TATATTCCAAATGGAGCGGCAGGCTTTTTA
110357
D AAATCGATT D：Dumas株
P AAATCGATT P：亲本Oka株
V AAATCGATT V：减毒Oka株
表5表示Dumas株、亲本Oka株和减毒Oka株基因11的重复区域R1(按5’端到3’端方向)的序列对比。
表6表示Dumas株、亲本Oka株和减毒Oka株基因22的重复区域R3(按5’端到3’端方向)的序列对比。
表7表示Dumas株、亲本Oka株和减毒Oka株基因22的重复区域R4(按5’端到3’端方向)的序列对比。
如在表5中所示，所有三个株即减毒Oka株、亲本Oka株和Dumas株的全部R1区域的重复序列是不同的。相似地，所有三个株即减毒Oka株、亲本Oka株和Dumas株的全部R4区域的重复序列是不同的。因此，R1区域的重复序列abbabba’bbb’abababx(其中，a代表核苷酸序列GGACGCGATCGACGACGA；a’代表核苷酸序列GGACGCGATTGACGACGA；b代表核苷酸序列GGGAGAGGCGGAGGA；b’代表核苷酸序列GGACGCGGCGGAGGA；和x代表核苷酸序列GGA)和R4区域的重复序列aaaaaaaaaaaax(其中，a代表核苷酸序列CCCCGCCGATGGGGAGGGGGCGCGGTA；和x代表核苷酸序列CCCCGCCGATG)对于减毒水痘病毒是独特的，而且这些序列对于减毒水痘活疫苗的质量控制是有用的。
对于表6所示的基因22重复区域R3的序列，在减毒Oka株和亲本Oka株克隆中，该序列是多样的。因此，在减毒Oka株中没有发现独特序列。
表5
R1区域(基因11)
减毒Oka株 abbabba’bbb’abababx
亲本Oka株 abbabba’bbb’ababx
Dumas株 abbabba’bba’bbbbabb’abx
a：GGACGCGATCGACGACGA
a’：GGACGCGATTGACGACGA
b：GGGAGAGGCGGAGGA
b’：GGACGCGGCGGAGGA
x：GGA
表6
R3区域(基因22)
减毒Oka株
克隆1 b’b’ab’b’ab’b’ab’ab’ab’ax
克隆2 b’b’ab’aab’ab’ax
克隆3 b’b’ab’aab’ab’ax
克隆4 b’b’ab’aab’ab’ax
克隆5 b’b’ab’ab’b’ab’ax
克隆6 b’b’ab’aab’ax
克隆7 b’b’ab’ax
克隆8 b’b’ab’ax
克隆9 b’b’ax
克隆10 b’b’ax
亲本Oka株
克隆1 b’b’ab’aab’ab’ax
克隆2 b’b’ab’aab’ax
克隆3 b’b’ab’ab’ax
克隆4 b’b’ab’ax
克隆5 b’b’ab’ax
克隆6 b’b’ab’ax
克隆7 b’b’ab’ax
克隆8 b’b’ax
克隆9 b’b’ax
Dumas株 aaaaabax
a：GCCCGCGCA
b：GACCGTCCA
b’：GCCCGTCCA
x：GGA
表7
R4区域(非编码区)
减毒Oka株 aaaaaaaaaaaax
亲本Oka株 aaaaaaaaaaax
Dumas株 aaaaax
a：CCCCGCCGATGGGGAGGGGGCGCGGTA
x：CCCCGCCGATG
实施例2
用实施例1中的同样方式分别制备减毒Oka株、亲本Oka株和Kawaguchi株(水痘病毒的野生型株)的基因组DNA。
应用在表8中所示的PCR引物01-N12(SEQ ID NO：5)和01-R13(SEQ ID NO：6)，PCR扩增对应于基因6的部分区域(对应于Dumas株的第5,372到第6,134位核苷酸的区域)，得到PCR产物。得到的PCR产物(763bp)用限制酶
Alu I消化，将DNA切割为片断，用RFLP分析确定限制片断类型。特别地，减毒Oka株、亲本Oka株和Kawaguchi株的每一个PCR产物都用限制酶
Alu I消化，因而得到DNA片断混合物，把得到的DNA片断混合物进行4.0％(w/v)琼脂糖凝胶电泳，以确定每一个DNA片断的大小。
对于减毒Oka株检测出两个片断的大小分别为170bp和593bp，对于亲本Oka株和Kawaguchi株检测出三个片断的大小分别为170bp、205bp和388bp。这些结果表示亲本Oka株和Kawaguchi株具有
AluI位点，其位于205bp的片断和388bp的片断之间，但减毒Oka株却没有这个限制位点。由这些结果证实基因6中第5,745位核苷酸A的突变可通过检测出缺乏
Alu I位点来证实。
实施例3
对来自水痘病人和带状疱疹病人的54个流行性水痘株分别进行RFLP分析。特别地，用与实施例2中相同的方式进行RFLP分析以确定通过用限制酶
Alu I消化PCR产物得到的限制片断类型的差异。作为一个结果，发现所有流行性株的PCR产物被切割成为三个片断，它们分别具有170bp、205bp和388bp的大小。这样一个限制片断类型与在上述实施例2中得到的亲本Oka株是一样的。
实施例4
用示于表8的引物(SEQ ID NO：3到6和9到18)和限制酶
Nla III、Alu I、
BstX I、
SfaN I、
Acc II、
Sac II、
Sma I、
BssH II和
NaeI的组合、或
Bsr I，用与实施例2相同的方式进行RFLP分析。特别地，用与实施例1中的同样方式分别制备每个减毒Oka株、亲本Oka株和Kawaguchi株的基因组DNA。接着，应用表8所示的PCR引物和在表9中所示的特别组合进行基因组DNA特别区域的扩增。得到的PCR产物用限制酶消化并走琼脂糖凝胶电泳。结果示于图2。并且，用来进行RFLP分析的限制酶和限制片断的大小总结于表9中。
如在图2和表9中所示，显然在进行RFLP分析所用的所有特殊条件下，从减毒Oka株中得到的PCR产物与从亲本Oka株和Kawaguchi株得到的那些是不同的。因此，对于第560位的C、第5,745位的G、第94,167位的C、第105,356位的C(第124,541位的G)、第105,544位的G(第124,353位的C)、第105,705位的C(124,192的G)、第106,262位的C(第123,635位的G)、第107,136位的C(第122,761位的G)、第107,252位的C(第122,645位的G)和第108,111位的C(第121,786位的G)，可通过RFLP分析证实核苷酸突变，而不用测定基因组的核苷酸序列。
表8
引物 核苷酸序列 核苷酸编号
01-N01 5’-TCGTTTACTGCTCGGATGGCGACCG-3’ 158-172
01-R02 5’-GTGTTTATGTATCAGCATACAGAGC-3’ 849-825
01-N12 5’-ATTGTATGCATGCGATTGCTATCGC-3’ 5372-5396
01-R13 5’-GGTCTTCCACTTTAAAGGGGTTTGC-3’ 6134-6110
10-N29A 5’-GAATCATTAGTATATATTTTTCTGC-3’ 26025-26049
10-R30 5’-TGTTCAGAGGGGATGAATCGTTGCG-3’ 26165-26141
50-N15 5’-CGATCACGTCGCTCACATCCAACCC-3’ 93685-93709
50-R17 5’-ATGGCAGAAGAAACACGTATTGCCG-3’ 64457-64433
60-N06 5’-GAGGACAACAGCTCCACCTTGACCG-3’ 105277-105301 124620-124596
60-R06 5’-GAGTAATGTGGCCGCCCGGTTTTGG-3’ 105613-105589 124284-124308
60-N26 5’-CCAAAACCGGGCGGCCACATTACTC-3’ 105589-105613 124308-124284
60-R28 5’-ATTACTGTCGACCCGAGACCTGGCC-3’ 106380-106356 123517-123541
G62-N04 5’-GATCAAAGCTTAGCGCAG-3’ 106736-106753 123161-123144
G62-R04 5’-CCTATAGCATGGCTCCAG-3’ 107499-107482 122398-122415
60-N11 5’-AAGGGCTTCCGTCGGGCATCATGAG-3’ 107729-107753 122168-122144
60-R12 5’-TCGGGTAAAAAGCCGGGCGATGAGC-3’ 108497-108473 121400-121424
表9
| RCR引物 | 扩增片段区(核苷酸编号) | 限制酶 | 限制性酶切位点 缺失突变(核苷酸编号) (核苷酸编号) | 限制片段大小(bp) | |||
| 01-N0101-R02 | 158-849 | Nla III | 560 | 560 | VW | 692402+290 | |
| 01-N1201-R13 | 5372-6134 | Alu I | 55425747 | 5745 | VW | 170+593170+205+388 | |
| 10-N29R10-R30 | 26025-26165 | Mae II | 2612526131 | 26125 | VW | 100+6+35106+35 | |
| 50-N1550-R17 | 93685-94457 | BstX I | 94172 | 94167 | VW | 487+286773 | |
| 60-N0660-R06 | 105277-105613124284-124620 | SfaN I | 105347 | 124550 | 105356124541 | VW | 33770+267 |
| Acc II | 105422105545105584 | 124475124352124313 | 105544124353 | VW | 145+123+39+30145+162+30 | ||
| 60-N2660-R28 | 105689-106380123517-124308 | Sac II | 105707106045 | 124190123852 | 105705124192 | VW | 118+338+336456+336 |
| Sma I | 106072106151106263 | 123825123746123634 | 106262123635 | VW | 483+79+112+118483+79+230 | ||
| G62-N04G62-R04 | 106736-107499122398-123161 | BssH II | 107136 | 122761 | 107136122761 | VW | 400+117+247764 |
| Nae I | 107252 | 122645 | 107252122645 | ||||
| 60-N1160-R12 | 107729-108497121400-122168 | Bsr I | 108113 | 121784 | 108111121786 | VW | 769384+385 |
V：减毒Oka株
W：野生型毒株(有毒株)
工业实用性
依据本发明的质量控制的方法，能够对减毒水痘活疫苗进行严格的质量控制和质量保证，特别是针对疫苗的安全性、有效性和单一性。进一步，本发明提供了可用于在水痘和带状疱疹的流行病学领域中的包括追踪种痘效果的研究的准确和先进的技术，并且这些技术可以加快和促进这些研究。因而，本发明为预防水痘和带状疱疹提供准确和非常有效的方法，为人类健康作出贡献。
序列表
<110>财团法人阪大微生物病研究会(The Research Foundation for Microbial Disease ofOsaka University)
<120>减毒水痘活疫苗质量控制的方法(Method for quality control of an attenuatedvaricella live vaccine)
<150>JP 2000-62734
<151>2000-01-31
<150>PCT/JP01/00678
<151>2001-01-31
<160>18
<210>1
<211>124884
<212>DNA
<213>减毒水痘病毒Dumas株
<400>1
aggccagccc tctcgcggcc ccctcgagag agaaaaaaaa aagcgacccc acctccccgc 60
gcgtttgcgg ggcgaccatc gggggggatg ggattttttg ccgggaaacc cccccccgcc 120
agcctttaac aaaacccgcg ccttttgcgt ccacccctcg tttactgctc ggatggcgac 180
cgtgcactac tcccgccgac ctgggacccc gccggtcacc ctcacgtcgt cccccagcat 240
ggatgacgtt gcgaccccca tcccctacct acccacatac gccgaggccg tggcagacgc 300
gcccccccct tacagaagcc gcgagagtct ggtgttctcc ccgcctcttt ttcctcacgt 360
ggagaatggc accacccaac agtcttacga ttgcctagac tgcgcttatg atggaatcca 420
cagacttcag ctggcttttc taagaattcg caaatgctgt gtaccggctt ttttaattct 480
ttttggtatt ctcaccctta ctgctgtcgt ggtcgccatt gttgccgttt ttcccgagga 540
acctcccaac tcaactacat gaaactactg tccggaaggg gaaggtattt attctcgctt 600
gcagcttgtc gcgcgtgtat gcacaacaaa agctatatat gtcaccaaag ccaacgtcgc 660
catctggagt actacaccca gtacgttgca taacctgtcc atttgcattt tcagttgcgc 720
ggacgccttt ctccgggatc gtggccttgg gacatcaacc agtggaataa gaaccgccgg 780
tggtcttgtt tgaacgacga gtggcgacgc gttgttctgc ataagctctg tatgctgata 840
cataaacaca gagtctgtat cgctatcaga ttcccgaaca ccttccggta ccccatactc 900
cgataccctg gacattgcgg atcccaaaaa tataatatta acaggatttg cttatacttt 960
gctacagctt atataaattt atgtgcgata catcttaagt gcatccgtac gttatttata 1020
cattgcctgt cacgtgaaaa gactgtgtta cccaataaag gttctacaaa aaatgcttta 1080
ttgggtgttt gtttaatagc tattatcgta acccaccccc gtaaaatcat aaaatgcatg 1140
taatttctga gacacttgca tatgggcatg ttcccgcatt tattatgggc tccactctgg 1200
tgcgtcccag tttaaacgcc accgccgagg aaaatcccgc gtcagaaacg cgatgtttat 1260
tacgagtgct tgcggggaga actgtagacc tgccaggcgg aggaacgtta cacattacct 1320
gtaccaaaac ctatgtaatt attggcaaat atagcaaacc cggcgaacgt cttagccttg 1380
cccgtctaat agggcgtgca atgacgcctg gaggtgcaag gacatttatt attttggcga 1440
tgaaggaaaa gcgatccaca acgcttgggt atgaatgtgg tacgggcttg catttactgg 1500
ctccatctat gggtacattt ctccgcacac acggtttaag taacagagat ctctgtttat 1560
ggcggggtaa tatttatgat atgcatatgc aacgtcttat gttttgggag aatatcgcgc 1620
aaaataccac tgaaacacct tgtataacgt cgacgttaac atgcaacttg acagaagact 1680
ctggtgaagc cgcacttacc acgtcagacc gacccactct cccaacccta acagcccaag 1740
gaagaccaac agtttccaac attcgtggaa tattgaaagg atccccccgt caacagccgg 1800
tctgtcaccg ggttagattt gccgaaccta cggagggcgt attgatgtaa tcactaaata 1860
aaatacacct tttttcgatt gtacgtattt ttatttaaat gtgtagttca tagtccgccg 1920
acagccgctc gggcttttcc cccacataca acatgatcgt atgcctcgga tgcaccggtc 1980
caacactccg ccgagaaggg ggatttacaa tgacagtgat acccaatagc cgccagatgt 2040
acacccagct gtccggactc cagcatcatc tgctgagttg cggcgctgaa gggtgcatcg 2100
catagggtgt tataattagc catttccggt aacagtcgtt gggaatttag gaggctgcaa 2160
aacggctgta ggtcaacata cattggggat tcagatggtt tatctcgacg tccaagtcca 2220
atcaaaaaag cgtgtaaatc atcagcccgg ccgcatgttg ctcgaagagc acataacctc 2280
ttaacaccgt acagagggga tggcgtcggt gcatgtgagt tggcagggca tgtccacgtt 2340
gtttccaacg ccagtggcgg tataacttgt gtaaacgacg ccaacgggtc aggtttaaga 2400
ttcactcgga tgggttgact gctttcggaa gctcccgttg tatccattaa ttaaacgttc 2460
ggtacacgtc tggtgtgtgt tttacccgaa tcagagacgg aattgcaaag atattggttt 2520
gaaagcaatg taatcccgcc catatatccc caacgtcgcc ttaaaaactc ccacaatatt 2580
acatttttat tagtctttta ttaatataga atcacataaa caattgataa aatcaagggg 2640
tggtgtataa tgattaaaaa tataaattga tatgttttac aagcatgaaa taggtattta 2700
ctattctaac aggtaaatat gcttaatgat taaaaataca aattagtatg ttttgacaag 2760
catgaaaaag gtatttttta ttttagcagt taaaggtact acacttaaaa tatttaccgt 2820
atggacgggc gtcagaaaga tgcccggccc aagttgagag ggtacattca acacgaccac 2880
actcgcgttg gtgggtgatt agggcctcta aaacaccggc cagacatgac ccgggtgtat 2940
attcttgtaa cacttgaacg ttacaactga tatcatcata ttccacaaat ttagagccac 3000
ggacaactat attagcaatg cgggcaatca taacaaacat ataagtagta atacacgtga 3060
tatcactaaa acgttgctgg cgcaacagtt cggggagagt acgagacccc aaatcgttgt 3120
ccctgtttag aagaagacat cttacaaaag gccccagctt taactttaaa ttctccaaaa 3180
gtgacttcga ggttgcaaca atgggattat ttgtgtagat gggcaagttt tttgccgcta 3240
acattttaat ccacgttaac agttcatccg cagactccaa cgcttcaatc aaagattctc 3300
cacgtatgac tctctcacgc aacgcgcggg caatacgtga gtccatttta tatgactcaa 3360
aggtacgata aagttcatgt ccgtacaaca tcaactccgg ccaagatgtg ttttgtttta 3420
tccccggaaa acatccaccg gaagcccatg aatcaccctc ttgtattgtg gcatatcgga 3480
ctaccagttt ttcaattgtt tcatctaaat ggcgtaccga gtcaatggtc acgctggctc 3540
ccgcggtgga gacgacttca atagcacggc ccgtaattcg atcgaccggg atatcatact 3600
cttttcgaat acgctctcgg cgggcgtctc tcttggaaaa tcgcaacctg tacgattcgt 3660
catgtgtctg atcatttctt tctcccgtgg tcattgcagg aggcgttgta ggacgccgtc 3720
ttcgatttga cagggatcga tcacggtgtt ttcttgaact ttgagtgtta taagatctgg 3780
atgatcgtcg atgtccccgt tcgatgcgtg catatccagt ctccacgtct cttcctccat 3840
gatggtttga atcgggtaat acaacaacca aagttttcgg gcgattgtgg tggtagcttt 3900
cacgccttcc gtgccttcgt ttggaatacc gtggattata tgctgtatct gcagtacgct 3960
ccacatacac agttctagac gttgtggagt cctcgcctgg agtggagcca atagcttcat 4020
catttgccca atcggtgact tccaatgcaa agtcatccga aggttcgtct ggtagcaaat 4080
tcataaagtc ttcacaaata gtagacacgt ctgggtcggt tggaattgaa gcagaggcca 4140
tggctgcaaa atatctgaca attgcgtgtt tgcagttgcc tgtatcttcc gccaatgttg 4200
tagaatttat aggctcaccc aaccccgcaa tgggcgtgtt tagtcacatg attaatgctt 4260
ctgggagttt tcactttccc caaacaagct tacctgcacc ctttgttcgt aatgcataaa 4320
aataaccact gctatagcaa atatgacgat ataaaaacat tttatagcaa ggccggacat 4380
tactgtagcg caacatgttg tgcatatacc acgtattccc cccgtattga tatgatttaa 4440
atgattatcc ttggttggtt ttggtctaac ataagatata agctctacta tagcgagcgt 4500
gcatacaaca acccaggcca gaatccgaat gtatgtgggg tataataacg cgcatggtgt 4560
atatgcaacg ccaagcgtta aaagcacaat acatccagat gatatatgag cgataacctc 4620
caaaagcatc aataacgtaa cacctttatg catatataaa aaacttatag ggtcagcatt 4680
aaatacttta ctcataccat cccgtcgcat ggaaacatca cataacaacc ttgccaactt 4740
tgtatatggg taaccaagaa gaatgttcga aataacccgt gttacgtaat tcagtgaata 4800
tgatgtgggg gatattaact cacaggatga tcggaatggc ccaaacatac gacgtattcg 4860
tcgaaattgt aaatacatac catatacaaa ccatgcaaaa aaaatcattt ttagctgcac 4920
gcaccaaaaa taagcgtgac aattacgtgt tcccagaaca attcgaattt tgtcatgcaa 4980
aggtgtagaa atagcggttt ttaccatagt atctcctgat aatagatttt cccggcagct 5040
gtaatcgtat ccagataggc catccaaaaa cgttgagtgg tttacaaacg ttacatatat 5100
aagagagttg ttataagacc cccatacaac cggtccacca ttaatcaccg tggttgcata 5160
cacacactca tgttcaaact ttacacgagc ggtataccat agggtaaaaa cagcatgtcc 5220
gctaagtaga cacataatta taaaatgttc tgtcttgatt cctaaagcct gcatgacccg 5280
tggaagatgg caattcaagc acgatgtagt atcacacggt tggtgttaac tcgaagttaa 5340
atttggataa ttaggtactt ctagagtaaa gattgtatgc atgcgattgc tatcgcactt 5400
tgtagcaaaa cattgttgtg caagcgaaat acacaaacgg ttgtgatgat ccactcgcag 5460
agacacaaat gtccggggag ccgttcttcc tccgcgatgg ggatatcgaa gacaagtgaa 5520
cccttttgtt ccgcatatga gctgaaataa cacccagtcc cttttgatgg cgatacactt 5580
tgatgatgtt aaggtatatt cgcgatcacg cccggggaaa tgaacagcaa tatgctccac 5640
aatagattct aatattgtgc tgtcgacaaa ggcctccagt gtaaatgcgt ccagacaagt 5700
taccccgcgc tcttttagag cctttgttaa agatatttgc ggggagctaa atatttgttt 5760
attacgcgca accttacgtt caaaaaactc tgcgtattcc cccccaaggt tatgtaaaat 5820
aaattgcact ggaacattcg actgcggtct tgaatgaaaa tgaaagtttg ccgggtttct 5880
atgtgatgtc acaaacgcta atatatcaat acactgctca ggtacaacat aaaatgggag 5940
tagttgtcca accgccgtcc ctgtggttgt tactttggag aaaaaaggca gtcttaaact 6000
atgtccgtgg ctataaacac cagtatctat aaacgaaaag tcccgtaaat acggaccaat 6060
atattcaaca aattcccgtt ccagcaacac cgcttgctgt aatatttgtg caaacccctt 6120
taaagtggaa gaccccacta acgcataggg atttgggatt ggtacgcata ccctgaaacc 6180
tattttctct ttacagttac agggtagagt ttcatgcaag ttttcattgt ttgatacatc 6240
ggcgtgtgta tggacttcag acgttgtctg tgtatcaaaa aaccatacat cctctgtata 6300
attctcttct acacacgtgt ataattcgcc attttctatg taaaaatcga tgtcagaatg 6360
gctggttata tccaataaat tatcatcatc caacacctca acggtaggtt caggacatgc 6420
agttttataa aaataacatg ggtctttgtt agggtttacc acggcctttg gaaaaagtaa 6480
ttgcatggcc gttaaaatac catgacgaaa tgctcgcatg ccggcatgta aaatacccaa 6540
tgggatgggt tttcttatat gaaagtctac atcaagtatg aggtttgtga ttataagatt 6600
tgtattaaat agctcattcc tgtttatata aagctgatct ttgggtatgt ttgatgaaat 6660
tttagaaacg tttttaacag acgtagataa tagtaaagtc aactgcatat ctcgtagtga 6720
agcggcaaca aaattacatg gattaatttg tttaaggtcc tccgcaatta atcgagcctc 6780
gtgcggtaaa gtgtaacggt ttgttattga tgaccacgta tcattagcaa taacagcaaa 6840
tgcttgggcg ccgtgaggca aggctacccg atatacaggc attggtccag ttacctcaga 6900
atggccgatg agggcttcta atggagtttt ataactcagg atggatacat catgtgtggc 6960
tatcccagtg gcagcagaga aaaacagtaa tagttttgta atccccgggc tcgtatcaaa 7020
accagtacga ccactttggt taggtgtatc gtttgcaaag ttggctgctc gtaacgcctc 7080
cgcggaaaca cccgaatcct caaaattaga caattcgtca aaaccgggtg gatttgaggg 7140
aatagtggag gaccatccat atggactaaa ttgtttttca atgttttcca cacgacgagt 7200
tagcgttgta gctaggtcac atacgcctat aaacttgcta ggttttgcgg catacgtaag 7260
acttaaagta tatgttttag taattgtata tttatgtcca atctcaggtc caagttcagt 7320
gacatcacaa attacgttct tttttatata gtcacgcatg ttgagacgag aacgtacatg 7380
attaaaaaaa ttagcagtag ctctttttcc caggttggat gattttaaga ggaccggttt 7440
attcacaaaa tctgagtatg taaccgcttg taggtggtct gcgatctgtt tccgattgaa 7500
acattcaaaa tgtgccagat aaatataatc aacaaattca cggtctggaa ctttaaggcc 7560
ttttctatcg ttggtaatat actccgatac tgcgtgtatt tccgttgtgt ctgtatgtat 7620
tcgctgtaaa atgtacgata gagcattttt ggctgtcaaa cctcgtgtat atgttgagga 7680
acaacaaaac atggaaagtt tatcaaaaga caacaagtcc gaaatattgt acccactaca 7740
attaggtaat gccgggactt ggtaagttaa aaacaaatct ttaattgcct gtaagtcata 7800
taagggggtt tccaacgtat tgtaacttgt gtccgtttgt aacaagtaat agcgtgtagc 7860
caacactagc gttttttcag agggtccaaa tcgaacaata taccaaaacg gcgagcatcc 7920
atacccccag tagagtcgtc gatatgcagc caatacttga cgttcgtaat gggcatataa 7980
tgatgttagc tcctgacgac caacggattt tttaactaac ttgcagagtg ttgcctctgt 8040
gatgcatagg ccgttgtccg ataatccctt tcggtttaaa tggtgtgttg ttaccatcag 8100
agtttgtata acttccgagt gaatgtcaaa cgtctccgat atacataggg tatcagatat 8160
tatatgcgga tttaggggtg ctccatacca taacgcctta tataaagctt taaaatcagt 8220
ttgggtttta aaacaacaaa aaaatatagg ccagacccgg gatcgtacat ctccagttga 8280
aaatccacca attaaataaa aaataacgtt gacgtcccta ctacaaaata aatgcattat 8340
ttggttttct tcatcgtttt cagttacttc acgtgggcgt ttagttggga ttacttgcgt 8400
gatctcttcc ctcccatttt tgacaaagac gtcatctaag tcgggagtcc aagtataact 8460
caccacatac agaggttctg tgcttatctg cccggtaagc aacaacagcg agtgggagat 8520
tgcacatccc tttgtggcaa ataataaccg aatcgtcggt ttggaggatt tatccatagt 8580
tcaatacgtt ggaaagccag tcaatcatgc agacggtgtg tgccagctta tgtggatatg 8640
ctcgaatacc aactgaagag ccatcttatg aagaggtgcg tgtaaacacg cacccccaag 8700
gagccgccct gctccgcctc caagaggctt taaccgctgt gaatggatta ttgcctgcac 8760
ctctaacgtt agaagacgta gtcgcttctg cagataatac ccgtcgtttg gtccgcgccc 8820
aggctttggc gcgaacttac gctgcatgtt ctcgtaacat tgaatgttta aaacagcacc 8880
attttactga agataacccc ggtcttaacg ccgtggtccg ttcacacatg gaaaactcaa 8940
aacggcttgc tgatatgtgt ttagctgcaa ttacccattt gtatttatcg gttggcgcgg 9000
tggatgttac tacggatgat attgtcgatc aaaccctgag aatgaccgct gaaagtgaag 9060
tggtcatgtc tgatgttgtt cttttggaga aaactcttgg ggtcgttgct aaacctcagg 9120
catcgtttga tgtttcccac aaccatgaat tatctatagc taaaggggaa aatgtgggtt 9180
taaaaacatc acctattaaa tcggaggcga cacaattatc tgaaattaaa cccccactta 9240
tagaagtatc ggataataac acatctaacc taacaaaaaa aacgtatccg acagaaactc 9300
ttcagcccgt gttgacccca aaacagacgc aagatgtaca acgcacaacc cccgcgatca 9360
agaaatccca tgttatgctt gtataaatat tgaaataaaa actaaaaacg tttctggtgt 9420
atgtttttat tttgtatata aaattaaaac attgctggct ggcgtggtta ttacatttaa 9480
tgttttagta gaaaatcgac atcgtttgtt tctttatcag ttgaaccaaa tccacgcgtt 9540
ccccgttcgc tgggtgtggc tattagatct aacgttttag taaaatacca ttgtacaccc 9600
ggtatgccac atttaccgcg gatagcataa ggaaatgcaa tattacttaa aacgttgtgt 9660
tttaagtgta tttgggtgtt gtgatctatt aacaggacct gtgcaagacg atctcccgtt 9720
tttatacgta tgtcatcacc cgtgagatta tatacgtaga atttacagtg ttctcctgca 9780
ggccatgccg ttggacacac gataatgcct gatcggcttt tcgatgatct tccaaaaata 9840
taagcgttta tactcggatg ttgtaagtcc cagtctctta taatcggtaa gacaattttt 9900
ataaattcat tcctttttaa atataggtta tatggtacac aaatatcata tcccgcgtct 9960
tcttggcgtt ttggattgat gatatgtttg taggttaagg gaacatcgat atggtattct 10020
gcagaatccc tatgtaaagg ttgcccctgc tgtaccgtgg aaatatcagc aaattcaggt 10080
ataacgggtt tttcataatt tgacggcgag tttgataagg gttgaacttg tatcgattta 10140
aaaattggat ccagatgttt aagaacgttt tttgggagaa ggcgactttg tcttaatttt 10200
accgggaaca agtagattgt taaatgtccg ggtaaaataa cggttactcc tggccggtaa 10260
tacaaaaggg ctgaaattac tcctctgtaa cccgcatcaa taactccgtt ggcgacaaaa 10320
aaattgtctt catcagcaag ggcagtatct ttgcattgaa ttaacaacag tgcgtattca 10380
ttgggaggcg ccgacttaac caacagctcc aactgctgca tataaaaacc gccccgtgtt 10440
acagattttt cagatggcag ttcgagtttc ttgtggttcc ggagtaacaa cggttgatgt 10500
cgacttactt tatcgtctaa cacgcattgc agcgtatctg cacattcagg ttgaacttct 10560
attaaaattg tatcttttaa acaccgattc ggaatagttt ggctacaaaa catatcacct 10620
gtatttactg ccgtttccaa gatgggatca attaccgctt cgttcatatt aataacgatg 10680
caaattttat ttttttgtga agacagcagt ggggagccaa actttgcaga acggaatttt 10740
tggcatgcca gctgttcggc tcgtggagtt tatatcgacg gatcaatgat caccaccctt 10800
ttcttctacg catccctttt gggggtgtgt gtagccctta tttcgttagc ttatcatgcg 10860
tgtttccggt tatttactcg ttctgtatta cgcagcacgt ggtaaacccg tttgcctata 10920
aaaggggcag gcgtgtataa gagggcccct gtttaatacg cggtctgccg tgtttggata 10980
tttcacgacc ctatcgttta tttacgtaat ggcatcttcc gacggtgaca gactttgtcg 11040
ctctaatgca gtgcgtcgta aaacaacgcc tagttattcc ggacaatatc gaaccgcgcg 11100
gcgaagtgtg gtcgtaggac cccccgatga ttcagacgac tcgttgggtt acattaccac 11160
agttggggcc gattctcctt ctccagtgta cgcggatctt tattttgaac ataaaaatac 11220
gacccctcgc gtacatcaac caaacgactc cagcggatcg gaagatgact ttgaagacat 11280
cgatgaagta gtggccgcct ttcgggaggc ccgtttgaga catgaactgg ttgaagatgc 11340
tgtatatgaa aacccgctaa gtgtagaaaa accatctaga tcttttacta aaaatgcggc 11400
ggttaaacct aaattagagg attcaccgaa gcgagctccc ccgggagcag gcgcaattgc 11460
cagcgggaga ccaatttcct tcagcactgc accaaaaacc gcaacaagct cgtggtgcgg 11520
tcctacgcca tcatataaca aacgcgtctt ttgtgaagcg gtccggcgcg tagccgccat 11580
gcaggcacaa aaggctgccg aagcggcttg gaatagtaat cccccaagga ataacgccga 11640
attagaccgt ttgttaaccg gagccgttat tcgtattacg gtgcatgagg gtttaaattt 11700
aatacaagcc gctaatgaag cagacctagg tgaaggagca tcggtatcca aacgtggaca 11760
taatcgaaaa actggagatt tacagggggg catgggtaat gaacctatgt acgcacaagt 11820
tcgtaagcca aaaagtcgaa cggatacaca aacgactggg cgtataacta atcgaagtag 11880
ggcccgttct gcatcaagaa ctgatacgcg aaaataggga tataattacg cagtaacggt 11940
ttacccggta ttatgtataa taaataaacg tataaaagac agtcgtggtt tgtgtttatt 12000
ataaatgtgt attatatgtc acatattata aactgtttaa atagtaccac gtggtattat 12060
gaacagttta taatcagttg ctaccaaaca aaccccatta gacggcgggt tttgataaag 12120
ggaatcgctt atttaaacta aagattttac tctataagta tggagtgtaa tttaggaacc 12180
gaacatccta gtacagatac gtggaatcgt agtaaaacgg aacaagcggt tgtggacgca 12240
tttgatgaat cgttgtttgg tgatgtagca tcggatattg gatttgaaac gtcgttatat 12300
tcacatgcag ttaaaactgc tccgtctccg ccttgggtag ctagccctaa aattttatat 12360
caacagttaa tacgggatct tgatttttca gaagggccgc gtttactatc atgtcttgaa 12420
acctggaacg aggatttatt ctcatgtttt cctattaatg aggacctata ttccgatatg 12480
atggttttat ccccggatcc agatgacgtt atctcaaccg tttcaaccaa agaccatgtt 12540
gaaatgttta atttaacaac ccggggttcc gttcgattgc ctagtccacc aaagcaaccg 12600
acggggcttc cagcttacgt tcaggaggtc caggattcgt ttaccgtaga actacgcgcc 12660
cgggaagaag catacacaaa actactagtt acttattgta aatcgattat acgttatctc 12720
caaggaacgg cgaaaaggac gacaataggt cttaatatac aaaaccctga ccagaaagct 12780
tacacgcaac tcaggcaaag tattctactt agatattatc gtgaggtggc aagtttggcg 12840
cgtcttctgt acctacattt atatttaacc gtaacgcgtg aattttcctg gcgtttgtac 12900
gccagtcaat ctgcacaccc ggacgtgttt gcggctttaa aattcacctg gaccgaacgt 12960
cgacagttca cgtgtgcgtt tcatcctgta ttatgcaacc acggcattgt gttattagaa 13020
gggaaaccac taacagcgtc tgccttgagg gaaataaatt accgccgccg agaactggga 13080
ctgcctctag ttagatgtgg tcttgttgaa gaaaacaaat ctccgttggt tcaacaaccc 13140
tcattttcgg ttcatttacc acggtcggtg ggttttctta cccaccacat taagcgtaag 13200
ttagacgcat atgcggtcaa acatcctcaa gaaccgagac atgtacgagc ggatcatcct 13260
tacgcaaaag ttgttgaaaa tagaaactac ggtagtagca tcgaagctat gattttagca 13320
cctccgtccc catccgagat cctgccgggg gacccaccac gcccacccac gtgtgggttt 13380
ttaacgcgtt aaacgtcatt ggggtagagg gtgtaaataa attacgaaaa cgtgcatgcg 13440
ttttttattt ttacaatgcg ccgtatatgg tatgtctgtc atgtgctcta aagtcccata 13500
tataaaagaa gccccaacga gtgtatgcgt attgcgtacc gcgaccctgg gatgttttac 13560
aggcgcgttt gtttgtctcg gttataagta tgcagtcggg tcattataac cggaggcaat 13620
cccgccgaca gcggatatcg tctaatacca cagactcccc ccgtcacaca cacggaacac 13680
gttatcggtc aaccaattgg tatacacacc caccccagat attgtccaat tcagaaacat 13740
tagttgcggt tcaagaacta ctgaactccg agatggatca ggacagcagt tctgacgcat 13800
cggatgattt tccgggatac gccttacatc attctacata taatggatcc gaacaaaata 13860
catcaacttc cagacatgaa aatcgcatat ttaaattaac ggagagggaa gctaatgagg 13920
aaatcaacat caatacggac gcgatcgacg acgagggaga ggcggaggag ggagaggcgg 13980
aggaggacgc gatcgacgac gagggagagg cggaggaggg agaggcggag gaggacgcga 14040
ttgacgacga gggagaggcg gaggagggag aggcggagga ggacgcgatt gacgacgagg 14100
gagaggcgga ggagggagag gcggaggagg gagaggcgga ggagggagag gcggaggagg 14160
acgcgatcga cgacgaggga gaggcggagg aggacgcggc ggaggaggac gcgatcgacg 14220
acgagggaga ggcggaggag gattattttt ctgtaagtca agtttgcagt cgagacgcgg 14280
atgaggttta ttttacgtta gacccggaaa taagttacag taccgatctt cgcattgcaa 14340
aggttatgga gcctgcggta tcaaaggaac ttaatgtatc aaaacgttgt gttgaacctg 14400
ttaccctaac aggctctatg ttagcgcata atgggtttga tgagtcctgg tttgctatgc 14460
gcgaatgtac ccgtcgcgaa tatattacgg tccaaggatt atacgaccca attcatttac 14520
ggtatcagtt tgatacttcc cggatgacac ccccacagat tttgagaact ataccagccc 14580
ttcctaacat gacacttggt gaacttttat tgatttttcc tattgaattt atggcccagc 14640
caatttctat agaacgtatt ttagttgaag atgtattttt agataggcgg gcttccagta 14700
aaacacataa atacggcccg cgttggaatt ccgtctacgc acttccatat aatgcgggta 14760
aaatgtatgt acaacacatt cctgggtttt atgacgtgtc cttacgtgct gtgggccaag 14820
gaacggccat ttggcatcac atgatattat ccacagcagc atgcgctatt tctaatcgca 14880
tttcacatgg agatggatta ggatttttgt tagacgcggc aattcgtatt agcgcaaact 14940
gtattttttt gggacgtaac gataattttg gcgtggggga tccatgttgg ttagaagacc 15000
atcttgccgg attaccacga gaagccgtac ccgacgtact ccaagtgaca cagttggttt 15060
tgccaaatcg gggtccaacg gttgccatta tgcgtggttt ttttggggcg ttggcatatt 15120
ggcccgaact aagaattgct ataagtgaac catctacatc tttggtgcga tatgctaccg 15180
gtcacatgga acttgccgaa tggtttttat tttcacgtac acatagttta aagccacaat 15240
ttaccccaac ggaacgggaa atgttagcgt cattttttac gttgtatgtt actcttggtg 15300
gaggaatgtt gaactggatc tgtagagcaa ctgcaatgta tttagctgct ccttaccatt 15360
cccgttcggc ttacatcgcg gtctgtgaat ctctgcccta ttactatatc ccggttaata 15420
gtgacctgtt atgtgattta gaggtattac tgttaggcga ggtcgacctc ccaactgttt 15480
gtgaatccta cgcaactatt gcacacgaat taaccggata tgaggctgtt cgcacagcag 15540
ccacaaattt tatgatagag tttgccgatt gttataagga aagtgagacc gatttaatgg 15600
taagcgcgta cctgggggcc gttttattgt tacaacgggt gttgggtcat gcaaatcttc 15660
ttttgttgct tctctccggt gctgcgttgt acggaggatg ttcaatttac atcccccgag 15720
gtattttaga tgcatataat actttaatgt tggcagcaag tcctctttac gctcaccaaa 15780
ctttaacatc cttttggaaa gaccgcgatg atgcaatgca aactttgggg attcgaccga 15840
caacggacgt tttacccaaa gagcaagaca ggatagttca ggcatcacct atagagatga 15900
acttccgttt tgtgggattg gagaccatct atccccgaga acagcccatt ccctccgtgg 15960
acctagccga aaatcttatg caatacagga atgaaattct gggtttggat tggaaaagcg 16020
tagccatgca tttactacga aaatattaag ggttgtgatt tttttcatta ggatgaaaag 16080
aacgtttcct agccacaccc acaaaggagt ttgtaaaata aaatctctgt ttagacctta 16140
aaatttgttg tgtgtgttgt gtggggggtc cgtgaggatc gacctttaca agatataatt 16200
tgtccatatc gcaatgtttt ctcggtttgc gcgttccttt tccagcgatg atagaacgcg 16260
taaatcttat gatggtagtt accaaagttt taatgccggc gaacgtgatt tgcccacacc 16320
tacccgggac tggtgttcta tttcccaacg cataaccagc gagcgcgtga gggatggatg 16380
tcttattcca acgcccggcg aggctttgga gacggcggta aaggctttat ctgaaaagac 16440
cgacagccta acatcgccgg ttttacaaag taccgaaaga cacagtgttc tgcttggatt 16500
acaccataat aatgttcctg aatcgttggt ggtctcgtgt atgtctaacg atgttcatga 16560
cgggtttatg cagcgttata tggaaacaat tcaaagatgt ttggatgacc tgaaactttc 16620
tggggatgga ctttggtggg tttatgaaaa tacatattgg cagtatctca aatacaccac 16680
aggagccgag gtaccggtga cttcagagaa ggtaaataaa aagtctaaat ccacggtttt 16740
gttgttttca tccgtagttg ccaataaacc aatatccaga catcctttta aatctaaagt 16800
tataaattcg gattaccggg gaatatgtca ggagctacgt gaggcgttag gagctgtgca 16860
aaagtatatg tattttatgc gtccagatga tcctacaaac cccagcccgg atacaagaat 16920
acgtgtacaa gaaattgcgg cttacacggc tactggctac gggtggatgt tatggttctt 16980
ggacgttgtg gacgccaggg tatgtcgcca tctcaaactt caatttcgac ggattcgagg 17040
gccgcgcgcg tctgttattc cagatgattt gcttagacga catttaaaaa cgggtcctgc 17100
ggtctcagcg ggcacaggag ttgcgtttat tttagcagca acaactgcca gcgctcttac 17160
tgcgcttttg cgtattagtg tattatggcg aaaggaagag tggcgggatg gtttaaatgg 17220
aaccgcagct gcaattgttg cggcggttga acttattacg cttttgcacc accattttca 17280
atacttaatt aatatgatgc ttattggata tgcatgttgg ggggatgggg gattaaacga 17340
tccttatata ttaaaggcgc tacgtgccca gggacggttt ttatattttg cgggtcagtt 17400
ggtcagaaca atgtcaacac acagttgggt tgtgttagag accagcaccc atatgtggtt 17460
ttcccgggcc gtggcgcaga gtattttagc acatgggggt aaacccacaa agtattatgc 17520
tcaggttctt gccgccagta aacggtatac tccgttacat ttaagacgta tatccgaacc 17580
atcgagtgtg tctgatcagc cgtatattcg ttttaatcga ctgggatctc caatagggac 17640
aggtataggg aatttggaat gtgtctgttt aacgggaaat tatttatctg acgacgtaaa 17700
tgcaagttcg catgtaatta atacagaagc accgttaaac agtatagcac ccgatacaaa 17760
tagacagcgg acttctcgcg ttttagttcg tccagacacg ggtttggatg taactgtccg 17820
aaaaaaccac tgtctggaca taggccatac ggacggtagt ccagttgacc caacgtatcc 17880
tgatcattac acccggataa aggcggaata tgaaggtccg gttcgggatg aatcaaacac 17940
aatgtttgac caaagatcgg atttacgtca catagaaacc caagcatctt taaatgatca 18000
cgtatatgaa aatataccac ccaaggaagt gggttttaac tcatcttcag acctggatgt 18060
ggatagcctt aacgggtaca cctccggaga catgcataca gacgatgact tatcaccaga 18120
ttttataccc aacgacgttc ccgttagatg taaaaccacg gttacgttta ggaaaaatac 18180
gcctaagagt catcattaag tacagcggtt aatagatagt tatggactag gcactttggc 18240
ggtcatttcc acaaccaggt taaaattggg ggatttggga gaaaatagtc tattgcgtat 18300
tttctgttca ataattggac tgcgttattt aaaggtctga ttggttgatt gggttataaa 18360
aggaattact cctttaaatt ttacttaatg tacccacaat atcaagtggt cgtttgtatt 18420
taacgattat taccggtacc atgggagact tgtcatgttg gacaaaggtg ccgggtttta 18480
cgttaaccgg cgaacttcag tacttaaaac aagtggatga tattttaagg tatggagttc 18540
ggaaacgcga tcgaacagga atcggaacgt tatctttatt tggaatgcaa gctcgataca 18600
atttgcgaaa tgaatttcct cttttaacta caaagcgtgt tttttggagg gccgtcgtgg 18660
aagagttgtt atggtttatc cgcgggtcaa ccgattccaa agaactcgcc gctaaagata 18720
tacacatatg ggatatatac ggatcgagca aatttctaaa taggaatggc ttccataaaa 18780
gacacacggg ggaccttggc cccatttacg gcttccagtg gagacatttt ggagcggaat 18840
ataaagactg tcaatcaaac tatttacagc aaggaatcga tcagctgcaa actgttatag 18900
atacaattaa aacaaaccca gaaagccgac gaatgattat atcgtcttgg aatccaaagg 18960
atatcccctt aatggtacta cctccatgtc acacgttatg tcagttttac gttgcaaacg 19020
gtgaattatc ctgccaagta taccagagat cgggggatat gggccttggg gtaccgttca 19080
acattgctgg atatgcactt cttacctaca tagtagcgca tgttacagga cttaaaaccg 19140
gagatttaat tcatacaatg ggggatgcac atatttactt gaatcatata gatgctttaa 19200
aagtgcagct agctcgatcc ccaaaacctt ttccttgcct taaaattatt cgaaatgtaa 19260
cagatataaa cgactttaaa tgggacgatt ttcagcttga tggatataat ccacaccccc 19320
ccctaaaaat ggaaatggct ctttaatgga tttttaaatg ttgtcaagac agtagatgtg 19380
ttgcgaatgt aataaaatga tatacacaga cgcgtttggt tggtttctgt ttatgaacag 19440
caacggatgc atagggttgc gataactgcg ataagaccca atgtcccaag gatagatatc 19500
acaccaatta taactgctac aacggaaaat gtagtggcgt aggtagatgc atcgtaggta 19560
taaacggccg aaaacggagg gaatttttta gggtaaccat ctagatgaca cgaataggtg 19620
ataggtccgt cgagttccga tgttggacaa gaactttgca tgtttacaaa ccgtttgttt 19680
tgatcacaca ccccagtaat ctcactgttt tcgtggttaa tgggagaatc gttaacccac 19740
catacgaaat gtacaacgcc acgtggcaca cattttgccg tacatactat gtgtccatca 19800
ataataccta tagacacgtt gggaaatgga tagacgtcag gggtaacgac agcagaatat 19860
ttcatattag agacgccatc ccgaatccat aaaacattac attggatggc tgggggtggg 19920
taatccattt gtttttgctg tggaattcgt accgccgaaa cataactaaa taatccattg 19980
gcatattctt gtattgcatc ggttataaaa ttttttccga tgttaccaaa ccttgaagtc 20040
caccgaacac gtaccgagtg cggtggataa tactttgata cgttacagta ggctgcgtat 20100
gtctgtccgg ttaagactgg atcgccgaca acggtaatat ttggacgata atacgttgta 20160
actgtaatac tgtgttccga tatgacgttc ttagtttttg tattaacgac tcgccaaata 20220
tacgttccct ccgtggtagc atccatagat aaaattgtta cagaaaaatc agacgttgtt 20280
ttaacatctg gtattacata attttcctta gcgtgtgtaa atatctcagg gttgtttatt 20340
aagtttaaat cggcactgtt gctatataac ataaccggta aatctggcat gcgtattaac 20400
gcattgccca gttgacggtg cggatctata aggtgacgcg taaaccaaac ttcaatatga 20460
agatcggggc gtataagcga cttccacctt gttatatttg aaccttccgg atctaaagaa 20520
tattgttcat atgttttttg ttgctgctta aaggccgcct gttgtccggt cgttagacgc 20580
atgtaacaag gcatgataaa tgtgtgaaaa tagggtatgg attgtattcc gccgtgaacg 20640
cattgtatat tttcatatag aaaaggtggt tgtgaatgtt gggtgttggc tgcgggatcg 20700
ggctttcggg aagcggccga ggtgggcgcg acggcgggat cgggctttcg ggtagcggcc 20760
gaggtgggcg cgacggcggg atcgggcttt cgggaagcgg ccgaggtggg cgcgacggcg 20820
ggatcgggct ttcgggtagc ggccgaggtg ggcgcgacgg cgggatcggg ctttcgggaa 20880
gcggccgagg tgggcgcgac ggcgggatcg ggctttcggg aagcggccga ggtgggcgcg 20940
acggcgggat cgggctttcg ggaagcggcc gaggtgggcg cgacggcggg atcgggcttt 21000
cgggtagcgg ccgaggtata taattcagtt atacttacgg gtgtgggttg agattcagtc 21060
gataattgta tacacgcgat cgttaaaatt aaatttattt gtatccgctt catcctggtt 21120
tttattgaca catccacgct ccccttaaat aaaagattaa aacacccacc gcggaattta 21180
aatgatggaa acgttttttt cgacattggg aataataaaa acggcttttg caactttaaa 21240
aactttattt atctcgatta cgatacatat gtaccacata gatagcatag atttattata 21300
atataaacac acacgtgata tactttagtg atatgagatg ccataaaaca gtcaataggt 21360
ttaacgctta gtctcatcat ctgaatacac gtcaaacccg ccgcaactgt tgatgttaga 21420
attataatag ctccccatga aatgccggca aatgttacag ctatacccgt caccgaggtc 21480
gttgtatata atacaattac ccataggttt tttttttctt gatataaaac ggcaaaaccc 21540
tgtaacccaa atgctataat atgacctcct attgaaactg ctaacgttac ttgtgtaagt 21600
ttgataaaat gatttaattt aattatatgt gagattgccc acattaatgg ggtaactata 21660
tataacaccg ggggtataac agacattata cgaattcctt taaacacgcg tttaagggtc 21720
cgggaacttt ctcgatggtc acatactctc ccgcggtcat tttgtgtata tacaacggca 21780
aaacctaaat ctgtataagt gtttaattgc ttatggcgat ttttacgata tatacacgta 21840
tcttgcaaat cggtggcggc atcgacaatt gaaactagtg tgacaataga tatacacaat 21900
ccaataagaa cctcatattt actgacatac atatataaaa taacggttag taaacctccc 21960
aacccagttc ccaacatcat aacataaaaa taaatatgcg gtccattgaa tgtcgtaaca 22020
aagttgtagt aatggatatg cacagcagcc actgttccgg taatcgcgga tatggaaatt 22080
cccagtaatt ctacaaatgg aagatcccgg gatattgggc aaccaaccgc ccataacaca 22140
gcaaaaccca acacgaccac cgtctgcaaa catcgtccca attttgctaa tgtgcgtaga 22200
aatttcacgg atgttggcca taaccccgaa acgacgatca accccataat agttgcattg 22260
acggcagctt cgcagacgtg atattgtaag attaacccgg acgtgataac gcttgcttgt 22320
agtcccacga gaaacaaccg cgatgctgag gttattgcac acgaattaca ttcttgaggg 22380
tttccggcac atccttggat tgattgagcg cggattaatt ctctgtctaa cacacccagg 22440
ttttcatcat ggacagctct ttcaccattc acggccatgt cttaagttta ataattcaaa 22500
acaaataaaa atgtgttcat ctatggtaca cacaagtttg tatgtaaaat ataagcaaaa 22560
gttgcactta tttaactgta catattacgt cagattcacg tgataattca gaataatcca 22620
gggttcctgc agggtccact ggaggagcca cacaatattc gcgaattccg attccctcct 22680
gccatgtggt ttcggggagt ttccccccca ttttatttcc ggtatttttt tcgtttcttt 22740
ttgttaataa attgcgtctt ttttttaatg gtggttcatc cttcacagat tccatgttcg 22800
caaataattg catcgaggtt aatttttctt taaggtcttt gggacttaag aacgttgcat 22860
aaaaaaaaga atgcacgggt gcggaacgtt ggatatacaa tccaaccatg ggggagttag 22920
ttaaggcgag ataaaaatta atataacacg tctcatcccg tgttaactta agattttgta 22980
cggcagaacg gaatccactg tgtgtttcca ataatactcc aaattcacgc atactcccgc 23040
tgccataaac aacattatta aggatccttt ttgaatttgt gattgagcgt attaaattat 23100
atggtgtagg cttgcttccg tttatatcca aggaaacatt aaatgagata aaaccacccc 23160
cggcggtctg gatgtacata tccgtggctg ttagaatgaa gcatgttgta aacccaaaag 23220
ttttaagtag tcgctgtaaa cgggtgaatt gatcgcgttt taagcaaatg cttatatctg 23280
gagttagatt tggaaacatc attgtataac aagcgagttc acgttttaca acttgtttgt 23340
aacattgtac ttgatcatct ggaccacaat cacccgggcg ttgccatacc atcgtttgga 23400
taatactccg ctcggggggt tgtccggtaa atttaaaata taaccgtgtt ggggtcgacg 23460
gatcttttgt atggcgaaac gcgtcaataa gcgaggaccg tccctccgtt gccgcgagta 23520
caaccattct cggcccagtc caattatact ggtcaaacat atttgccggt ataggaatat 23580
acagttgttc tgtttccaaa ctacagtgaa taattaatcc ttcgtcgctg aatattaaaa 23640
tagaatccct tagtctatta accagaggtg atatagacga aattaaacca gtaagcgttt 23700
tttccgttaa aacagctctg gcgatttctg gggcgtcaaa acccgcatgc aattccatgt 23760
ccaaagcatc gtctgtacgc gacctcaaat ccataattta ctacttaaaa tgtttactat 23820
agaaaaagta atcatatgta aacacacgag tttcgttaat atgtttgttt aacccgatcc 23880
ggtgacttaa gtacataaac aggcatgata tttgaatagt acggcccatg ggagggaaca 23940
tttccacgtg ttccaataca gggggtgttc cttaataggg actgtgcaat aaaatacgta 24000
agaagttacc agatttgatg taatgtttgt cataaaaaat atgtacatca ttatatacgt 24060
ctgtaattaa cacaagatca catcgaagaa ttactgaagc cgctgtgaaa cctttcacaa 24120
gacgatataa acttggttaa gtgtattgat ggggctcttt ggactgacac gctttatcca 24180
tgaacataaa ctggttaaac ccagcatcat ttcaacgcca cccggagttt taacccccgt 24240
ggcggtagac gtatggaacg tcatgtacac attgttggaa cgtttatacc ctgtgggtaa 24300
acgcgagaat ttacacggac catctgtaac gatacattgt cttggagtct tattgcggct 24360
attaacacaa cggtcatact atccgatatt tgtattggaa cgttgtacag acggcccatt 24420
atcacgtgga gccaaggcaa ttatgtcacg ggccatgaac cacgatgaaa ggggaacctc 24480
ggacttaacc cgtgttctac tatcatccaa cacatcatgt tctatcaagt ataacaaaac 24540
atcggaaaca tatgacagtg tgtttcgaaa ctcttccacg agttgtattc ctagcgaaga 24600
aaacaaatcc caggatatgt ttttggacgg ttgtccacga caaactgaca agacgatctg 24660
cctgcgcgac caaaacgtat gcagtcttac ctctacaatg ccatcccgag gacatcctaa 24720
ccatcgatta tatcacaaat tgtgtgcaag tcttattaga tggatggggt atgcatacgt 24780
cgaggcggtt gacattgagg cggacgaggc atgtgcaaac ttatttcata cgcgtacagt 24840
ggctttggtt tatacgacag atactgattt actcttcatg ggctgtgata ttttgttaga 24900
tgcaattcct atgtttgctc cagtagtacg atgtcgcgat ttgcttcaat atttaggaat 24960
tacataccct gaatttttgg ttgcctttgt tcgctgtcag accgatttgc atacaagtga 25020
caacctaaaa tctgttcagc aagttattca ggataccggc ctgaaagttc cacatcaaat 25080
ggacacttca acgcgctccc ccacttacga ctcgtggaga catggcgagg ttttcaaaag 25140
tcttaccgta gccacgtcgg gtaaaacaga aaacggagtg tccgtttcca aatatgcatc 25200
taaccgatcg gaggtgacag tagacgccag ttgggcttta aaccttctgc caccctcatc 25260
ctccccattg gataatttgg aacgcgcatt tgttgaacat ataatcgccg tggtaactcc 25320
attgacccgc ggtcgcctaa agttaatgaa acgtgtaaat attatgcaaa atacggcaga 25380
cccatatatg gttattaaca ccttatatca taacttaaag ggggaaaaaa tggctcgcca 25440
atacgcacgt atttttaaac agtttattcc tactccactc ccactaaaca ctgtattaac 25500
aaaatattgg aattaaaaca cacataagag cgacttaatg gttcattgtt ttattttgct 25560
cgtatataca tgttataaat cgtttatcac tgtgcccgca taagatgtac tgtgtctctc 25620
aaaaaaattt gtgtttttat ctgcaatcat aaatgcaagt ggaaagtccg aatcgggagg 25680
tggggtgtta aatagttttg gtacattaat cgctgataaa agcctgtccg cgctgaattt 25740
cacgtattgt gtaattgcat cgacgttcac caaacgggtt ttgggtgcat gggattttaa 25800
aaacgcacac tcgatttcaa cggcttccga aaacagttga tgtattctgg tgatagcggg 25860
tttttcgggt acatagttat tgtatataca acacgatgcg ctggtatgta tggcttcatc 25920
tcggcttata aggtcgttaa attgacaagt tacaacaaat agtccgttat tgcgtaaata 25980
tgcaatagcc gcgaacgatg atacaaaaaa aatgccctct ataagaatca ttagtatata 26040
tttttctgca acggatgggt tgtcccgtac cttttcttcc aaccattgta ctttttgttg 26100
gatcgacgga ttattaatag tgacatttac gtattgtacc cgcaacgatt catcccctct 26160
gaacaacatt agttgaattt gactatagac acgcgcgtgg acaacctcga tgcactcttg 26220
ttcaatgtag taatggtgaa tatccttttg ggaaaagagt tgggttagag agcccaaatt 26280
aacatttacc agatcatctg ccgccgataa aaatgtaaaa ataaatctgt agaatattag 26340
ttcatcttcc gttaaacagt ccaagtattg ataatcatct tcaatgataa aatcgctttc 26400
taaccaacga ttcgaaatgc tcagggcacg taaattgttt atatctggac actccggcct 26460
gtaaaaaaaa tgactgcaat ctttctgatc cattttggaa tagtttcccg tgtaaattta 26520
taaagcacaa ctggtacagg ttaattcgcc tcccgcagac agtccgctgt tcgtagcttt 26580
acgaatttta cagtagtaca tacccgtttt aaggccggct ttataggcac gtataagcaa 26640
attcattatt ttggaggcgg gaattgtccc gtctgggcgt tcctcaataa ataaagtcat 26700
tgattgactt tggtcaataa atggcgccct ttctgcacac atatcaacga gatcctcttg 26760
ctcatattca aacgctgttt tatattttaa gagtgggtga ctattagata aacagccaaa 26820
cgaacgtatt actgaccatt ggtttttctc aagtatgttt ataacttcca gtcgtttttc 26880
ttcacatgaa tacatatctc ttagttcgtc cataaggtct aagttgggtc taagtaactc 26940
acccgaggtg gtgaccttac taaacatatt attataaatt ggagagaaac cctcactgca 27000
ctccgttacc tgtgcagatg aaactgtggg cattaacgct aagaactgcg agttgtataa 27060
cccataagcg caaatatcat ctcgcagggt acaccatggt aaatctaaat aacttatcgt 27120
agaaaaccca tcttggtgta accatccctt agcatattta ctttcggtaa aacccttaaa 27180
cggggctaag ccgccaatct tacacatttc catgcttgtt ttcattgtct catacaacat 27240
taactccgct atttgtacat ttaaccgtct agctggttgg gaagttaaat caaatcctaa 27300
gcggagacaa gttgtatgta acccttgtat gccaatgcca agtgatcggt tgttttttac 27360
acctttacat gattttttac atggaaagtt cccagccgcc aggaccccgt ttaaaaaaat 27420
aacagtcgtt cttgctgtca attgaaggtc gtttaaatta aatgacactg ggcctttgga 27480
taagcacgtt gtaagattta tgctggcaag attacatacg ccatgttgat gagcgtctgc 27540
cttttgaaca atttccgtac acaaatttga ccccgtgata gcatttcctt gggtattcat 27600
atgataatta cgattacagg catctttgaa cattaaaaag gggcttcctg ttacagcagc 27660
actgcgtatg attgtgaatg cgatatcttg aatgggaaca gaagaaacgc ctaatccttc 27720
tctctctaaa cgtaaatagg ttgaagtgaa tgcctccccg tgtaatgttc gaaggatatc 27780
ggctctgtta tcaaaaagag tccactgaac attactagcc ccttttagat agcttaggta 27840
tctttcaaaa aataaatctg gggtccataa acaacaaaat atgttatcac atcgaaatat 27900
ttcatcacga accaacattc cacgtgtggc caaaacagtt tgtagatcga cgtgccatgg 27960
ttctatgtaa acacaaactc cagttggtcg ttcacaatca ctgttaattg ccataaccat 28020
gcaatctaaa agttttaaaa ctgcaagaag acctttcgtt tgattttccg taggtattaa 28080
attcagactc tgtagagaaa ttcccactcc acctcgactt tgtaataccg ttcccacatc 28140
gcctgtgata gctcgaacag ctctcccaac agtgatggat tccgggtcca ttaaataaca 28200
actggccgtt gccccggtct ctcgacctaa aaacatcata accggtgtag ccgggacaat 28260
tttctgacat gccaacgctg tgaaaaatac ccgacagaca tcagtccatg tataaccatc 28320
atttattccg ggaataagag ttgcgatttt aggcaggttt acgatttctg ttgtcacggt 28380
ggccgccagt cttaaaaaga attggcaaag cgactctaat ttaccttcct ctaacttagt 28440
taaataaaag tcttcgtact ttaaagcaga ctgtagtcca agggtagcta aagcggggta 28500
ttgatctttc aaaaacggtt ctaatatagc ccgacgaatt tcgtccctcc gcccttcaat 28560
tgcttggcgg actcggggag ttaaacagag aattggggaa gtcaaccacg tttccatgga 28620
aacggatcgt aggttaatac ggcaatggat aagttctcca caacatcggt acactcgctc 28680
atcttgtcgc gtcaccgcct taagttttga gacgatagtg ctaatatact ccattaattc 28740
caccggtgtg gttgattcgg gcggaatgat gtattccttg tagccatgtt gacataatcg 28800
gtttataatg tcatgaaccg tattaaaaat tcttttgaac tccataacgg ataacgtatt 28860
taggctccgg aataaacctt taaaccctaa actcacagct gagttagttc tacaatattg 28920
tagactccct tatatatggt tacgtacagc ctgcccctcc ccagtatata atatcacgca 28980
aaacccacgc tatgttaaat tcagtttatt ttacatacat gctttaataa taacattcgt 29040
tccatgtatt tgtacccccc cacacaaccc cctctaacca aatagttggc acgttataac 29100
ctccgaaccg ttccatgcgt cttgtataac gcacagactc tgatggaatt gttccaatta 29160
acgtatatgc cgcatacatg caggataatt gtgtgggaag tccccgaaaa tcgccggtcc 29220
attgatacaa tcgctgtcta gccaagttcc aatttactcc tgtaatttcg ccaatactac 29280
atcgagggct tgtcgggtca ttggataact gcacaagcgg caacgccctt gtgttatatg 29340
gctggtgggt atttgcaacc ccttcagtcc cccaggcggc attttcagct cgtatgcgtc 29400
ctaacaggaa gccaatacca cgaccaaaac attgttcgtt tagttggctt aatgcaagat 29460
gcagtcttac accttctcgt tggcgtcgct gtgtatatac aaaaaccaag aacacatgct 29520
tcagtccgtc cgcggaaaga tgtaaatctt tgtcaacgtc ccaaaatacg caggccggga 29580
tgttggctgt gaccctgcga gttgaagttt tgtctgtacg tgcagcttct tggggacctt 29640
tggccacggc ggttatattg cataaattat cctgaatggt atattccagc agggacccaa 29700
aaaaacttat aaatcgatgt ggaaatacat gacattgtac catcgcacgt aaacactccg 29760
aaaaccttat gagccgcgtt tccatacgac tgcatccata ggcagaaaca attgctgttc 29820
tgttggcatc cgctgcctgt ttatccgtat attcttctgc ccggcatgcg gcgatgaaac 29880
ttaatgacgt tacatatgct ctaagccccc caccttctcc aacggtccaa ggagccgtgc 29940
aggcattgaa taggtttcgt aaaccctcta gtagtacatc ggggtcacgt ccagcctgtg 30000
taagtgtatt agcttctcca atcatgtcag atggatgacg aaggattaag acgattgacc 30060
cagcatgctc aatgtccgga cgaaaaaaat cggttaatga cacttgttgg attagctgtg 30120
tcgttgattt aaaattattt aacgggagtc taatggtaac ttgcgggtta ccaattgaag 30180
ttggatttat ttgaatgttg ttcatacgat taataacaat tgaacggggg gttacttgaa 30240
tagacgcggt ttctgtacgt tttggtggta catgtatcgg ttgtttgttc agacctccaa 30300
agcgagggcc aattgttaaa tcgcgactcc aatttccgaa gaagcccgga gcataagtca 30360
tatgaagccc gttccctatt tgaataaaac ggttatttcc taaaagactg atattagttc 30420
cacatagcgt ttgttcgttt aaagtaaaat gcgagttggt tggttgactc cccatagctg 30480
aggggttaaa ttcacacaat gcaatcgtga cgtggtacta tctgaaatgt tgcctggggt 30540
atgtgtacac attatacagt cgtagtaccg tttatataat gttaggtagg aggagcctat 30600
aaaaatattt tgattggcgt taaaaggttc ttcaacttac cgtgacgtcc tttttattaa 30660
catgcgtttt tattgatgtt acatttatgt cttttcattc cggacggatg tagctttttc 30720
atatcacgtt ataaagttaa gtcagcgtag aatataccat ggaagaacca atttgttatg 30780
atacacaaaa acttttggat gatttaagta acttgaaagt acaagaagcg gacaacgaaa 30840
gaccatggtc accagagaaa acagaaatcg ccagagttaa ggtagttaag tttttacgat 30900
ctacccagaa aattccagct aaacatttta ttcagatatg ggaacccctg cattctaata 30960
tctgttttgt atattccaat acatttttgg cggaggctgc tttcacggcc gaaaatttac 31020
ccggactgtt gttttggaga ctagatctag actggacgat agaggagcca ggtaatagct 31080
taaaaatttt aacccagcta tcaagtgtag tacaagattc cgagacgtta catcgtttat 31140
cggccaataa attacgaacc tcgtctaaat ttggacccgt ttcgatacac ttcattataa 31200
cggactggat aaatatgtac gaggtcgcct taaaggatgc aacaacagcc attgaatcac 31260
cattcactca cgctcgtatt ggaatgttgg aaagcgccat tgcagcttta acacaacata 31320
aatttgcgat catttacgat atgccatttg ttcaagaggg gattcgtgtt ttaacacaat 31380
atgcaggatg gcttcttccg tttaatgtta tgtggaatca gattcaaaat agctcactca 31440
ctcctctaac acgagccctt tttataatct gtatgattga tgaatatctc acggaaacgc 31500
cagtacatag catatcagaa ttatttgcag atactgtaaa tttaattaaa gatgaggcgt 31560
tcgtatccat cgaagaagcg gtaacgaatc cacgaacggt gcacgagtca cgaatttcct 31620
cagctctggc ttatcgagac ccttatgttt ttgagacatc cccgggaatg cttgctagga 31680
gacttagatt agacaatggt atatgggaaa gcaacctctt atcgttgtcc acccccggaa 31740
ttcatattga ggcgctgtta catttactaa actccgaccc ggaagcggaa accacatctg 31800
gaagtaatgt agcagaacac acccgtggca tttgggaaaa ggttcaggct agtacatcgc 31860
ctagtatgtt aataagcacc cttgccgaat ccgggtttac aagattttca tgcaaattgc 31920
tacgtcggtt tattgctcac cacacactcg ccggttttat tcacggaagc gttgtagcag 31980
acgagcatat tacagatttc caacaaacac taggatgtct cgctttagtg ggtggactgg 32040
cataccaatt agtggaaacg tacgctccta ctaccgagta tgtgttaaca tatacacgga 32100
cagtaaacga gaccgaaaaa cggtatgaaa cgctattacc cgccttagga ttaccaccgg 32160
gaggcctggg acaaattatg cggcgctgtt ttgctccacg accccttatt gaaagtatac 32220
aagcgacacg cgtaatacta cttaatgaaa tttcacatgc agaagctaga gagacaacat 32280
attttaagca aacacataat caatcctcag gtgcgttatt accacaagca ggacaaagtg 32340
ccgtacgcga agccgtacta acctggtttg acctacgtat ggattcaaga tggggtatta 32400
ctcccccggt ggatgtgggt atgacacctc ctatttgtgt tgatccaccg gctacagggt 32460
tggaagctgt catgataaca gaagcactaa agattgcata tcctaccgaa tataatcgct 32520
ctagcgtgtt tgtggaaccg tcgtttgtgc cttatattat tgcaacaagc acgcttgatg 32580
ccctttcggc aacaatagct ttgtcttttg atacacgggg aatacagcaa gccttgtcta 32640
ttcttcagtg ggctcgcgat tatggatccg gaaccgtgcc caatgcagat ggatatcgca 32700
caaaactatc tgctcttata acaatattag aaccttttac ccgtacacac cccccagtac 32760
ttttaccatc tcacgtttct actatagatt cccttatatg cgaacttcat cgggctgttg 32820
gcattgccgt tgacctgctt ccccagcacg tccgtccttt ggttcctgac cgtccttcta 32880
ttacaaatag cgttttttta gcaactctct attatgatga actttacggt cgttggaccc 32940
gactggataa aacatcgcag gcgttggttg aaaattttac atccaacgcg ttagtggttt 33000
ctcggtacat gttaatgtta caaaaatttt ttgcgtgtcg tttttatcca acgccagatc 33060
ttcaggctgt tggtatctgt aacccaaagg ttgaacgcga tgaacaattt ggggtatggc 33120
gtttaaacga tcttgctgat gcggttggtc atattgttgg gacaatacaa ggaatccgaa 33180
cgcaaatgag agtgggaata tccagcctgc gcacaattat ggccgatgct tcctcagccc 33240
ttagggaatg tgaaaattta atgactaaaa cctccacttc tgctattggg cctctttttt 33300
caacgatggc ttcccggtat gcacggttta cacaggatca aatggacatt ttaatgcgtg 33360
ttgacaaact aacaacagga gaaaatatac ccggtcttgc aaatgtagag atttttttaa 33420
ataggtggga acgaatagca acagcttgta ggcatgccac ggcagtcccg tcggccgaat 33480
ctattgcaac cgtgtgtaat gaattgaggc gcggtttaaa aaatatacaa gaggatcgtg 33540
taaatgcccc aacctcatat atgagtcacg cccgaaatct ggaagatcac aaggcagcag 33600
tttcattcgt tatggactcc aggcaacagt ttattgtgga ttctggacct cagatgggcg 33660
cggttttaac ttcacaatgt aatataggaa catgggagaa tgtaaatgca acgtttttac 33720
atgataatgt taaaataacg acaacggtca gagacgtaat ttcagaggct ccgacgctga 33780
taataggaca aagatggctt cgtccagatg agattttatc taatgtagat ttgcgtcttg 33840
gcgtacccgg gaatacaagt gggagtgacc cttaatataa aacaggcgtg tttatgtaca 33900
ttaaagtatt tgtggttttt attgactggg cgtttcgttt gtataacgct gttgttgcta 33960
gtattttcat aacctcctag gtttttggag ctacacgtgc ttattcaacg ctctttggga 34020
tttgaatcat cgtaaacgta gcgtccctac cagttgagcg cgtaattttc gtaagcaata 34080
aaatggatat aattccgcct atagctgtca ctgttgcggg agtgggaagc cgtaatcaat 34140
ttgacggtgc cctgggaccg gcgtcaggtc tgtcatgttt aagaacatct ttatcgtttt 34200
tgcatatgac atatgcgcat ggaattaatg caaccctgtc atcagacatg attgatggat 34260
gtttacaaga gggtgcagca tggactacgg atctgtctaa tatggggagg ggtgtcccag 34320
atatgtgtgc tcttgttgat ctccccaatc gaatttcata tattaaactg ggggacacta 34380
ccagtacgtg ctgcgttttg tctagaatat acggcgatag ccattttttt accgttccag 34440
acgagggttt tatgtgcaca caaattcccg ctagagcgtt tttcgatggt gtgtggatgg 34500
gacgtgaaga gtcgtataca attataactg tagactcaac gggaatggcc atctatcgtc 34560
agggaaacat atcttttatt tttgatccac atggccatgg gactatagga caggctgtag 34620
ttgttcgggt gaataccacg gatgtgtact cttatatcgc atcggagtat acccaccgcc 34680
ccgataacgt agaatcccaa tgggccgctg cattagtttt ttttgtcacc gcaaacgacg 34740
gtcccgtaag cgaagaagcg ctatcttcgg cagtaacgct tatatacgga agctgtgata 34800
catattttac agatgaacaa tattgcgaaa aactggttac agctcaacat ccgttgcttc 34860
tttcacctcc taattccacg acaattgtgc ttaataaatc gtctatagta cctcttcacc 34920
aaaacgttgg tgaaagtgta tccttggaag caaccctaca ttcaacgtta accaacacgg 34980
ttgcactgga ccctagatgt agttacagcg aggttgatcc ttggcatgcg gttctagaaa 35040
caacctcgac tgggtctggc gttttggatt gtcgtcgtag acgccgtcct tcatggactc 35100
ctccttcaag cgaggaaaat ttagcttgta tcgacgatgg cttggtaaat aatacacatt 35160
ccacggataa tttacataaa cccgctaaaa aggttctcaa atttaaacca actgtagacg 35220
tgccggataa aacacaagtg gcacatgtat taccccgcct acgagaagtt gctaacaccc 35280
cagacgttgt gttaaatgta tccaatgtag atacgcctga atccagtccc actttttcac 35340
ggaacatgaa tgtaggaagc agtttgaaag atcggaagcc atttctattt gaacagagtg 35400
gtgatgtcaa catggttgtc gaaaaactac tacaacatgg gcatgaaatt agcaatggat 35460
acgtacaaaa tgcggtgggt acgttggata ctgttattac cggtcataca aatgttccca 35520
tttgggtaac aaggcccttg gttatgccag acgaaaagga tccattggag ctttttatta 35580
acctcaccat tttgcgttta acgggatttg tggtggaaaa tggaacacgt acacatcatg 35640
gtgctacaag cgttgtatca gactttatag gtccccttgg ggaaatttta acaggatttc 35700
cctccgccgc ggaacttata cgcgttgcaa gtttgatatt aacaaacatg ccgggggcgg 35760
aatatgctat taaaactgtt ctccggaaaa aatgtacaat tggcatgctc attatcgcta 35820
agtttggtct agttgccatg cgggttcagg atacaaccgg cgctttacat gccgaactag 35880
atgtgttaga agcggatcta ggaggttcgt cgcccataga cctctattct agactgtcga 35940
caggtcttat aagtatacta aattcgccta ttatttctca tcccggactt tttgccgagc 36000
ttattccaac ccgtacaggg tccctgtctg aacgaatacg tcttctttgt gaattagtct 36060
cggcccggga gacacgctat atgcgtgaac acaccgcgct tgtttctagt gtaaaggctt 36120
tagagaatgc attacggtct acccgcaata aaattgatgc cattcaaata ccagaagttc 36180
cccaggaacc cccggaagaa accgacattc cacccgaaga gttaattcgg cgtgtatatg 36240
agatacgatc cgaagttaca atgctattga cctcggctgt tacagaatac ttcacccgcg 36300
gagtgttata tagcacacgg gccttgatcg ctgaacaatc ccctaggcgt tttcgggtcg 36360
cgaccgcaag tacggcaccc attcaacggc ttttagattc tcttccggaa ttcgacgcta 36420
aattaacggc aatcatatcg tccctgtcta tacaccctcc tcctgagact atacaaaatc 36480
tccccgtcgt atctctgtta aaagagctta ttaaagaagg ggaagattta aacacagaca 36540
cggctctcgt atcgtggtta tctgtagtcg gggaagctca aaccgcaggt tacttatcca 36600
gacgagagtt cgatgaatta tcacgtacaa ttaaaaccat taatacacgc gcaacgcaac 36660
gggcttccgc ggaagcagag ttgtcttgct ttaatacgct aagcgcggcc gtagaccaag 36720
ccgtaaagga ctatgaaaca tataacaatg gtgaggtcaa gtatcctgaa ataacacggg 36780
atgatttatt agcaacaatt gtacgtgcta cagacgattt ggtgcgacag ataaaaattt 36840
taagtgatcc aatgatccaa tccggtttac aaccttcgat taaaagacga ttggaaacaa 36900
ggcttaaaga ggttcagacg tatgcaaacg aggcccgaac cacacaggac acaataaaga 36960
gtcgaaaaca ggcggcatat aataaactcg gggggttact tcgcccggta accggttttg 37020
tgggacttag ggctgcagta gatttattac cggaacttgc ttctgagtta gatgtccaag 37080
gagccctggt aaatctcagg accaaagtct tagaggcgcc ggtagagatc cgttctcaac 37140
ttacgggtga tttctgggcg ttatttaacc aatatcgaga cattttagaa catcccggaa 37200
acgcacgcac atctgtctta ggaggactgg gagcttgttt tacagctatt atcgaaattg 37260
tgccgatacc tacggagtat agaccatcat tgcttgcgtt ttttggtgac gtggcagatg 37320
tgcttgcatc cgacatcgcg accgtatcta ctaacccgga aagtgagtcc gccataaacg 37380
ctgttgttgc aactcttagt aaagcgacgt tagtttcatc tacagtgcca gccttatcct 37440
ttgtgttgtc gttatataaa aaatatcagg ctttacaaca agaaattacg aatacccata 37500
agttgactga attacaaaaa caacttggag atgacttctc caccctagct gtctcatctg 37560
gacacttgaa gtttatatca tcttcaaatg tagatgatta tgaaataaac gatgcgatat 37620
tatcaataca aacaaatgtg cacgccctaa tggatacggt taaacttgtt gaagttgaac 37680
tgcaaaagct acccccccat tgtattgctg ggacatctac cttatctcga gtagtaaagg 37740
atcttcataa actcgtcaca atggcacatg agaagaagga acaggcaaaa gtgttaatta 37800
ccgattgtga acgtgcacat aaacaacaaa cgactcgggt tttgtatgag cgttggacac 37860
gtgatattat agcatgtctg gaggcaatgg aaacgcgcca tatatttaac gggacagaac 37920
tggcacggtt gcgagatatg gccgctgcgg gagggtttga tatacacgca gtttacccac 37980
aagcacgtca ggttgtagcg gcatgtgaaa ctacagccgt tacggcatta gatactgtgt 38040
ttcgccacaa tccatatacc cccgaaaata caaatattcc accacctttg gctttgttaa 38100
gagggttaac atggtttgat gatttttcga ttacggctcc cgtattcacc gttatgtttc 38160
caggtgttag tattgaggga ctccttctgc ttatgcgtat tcgcgcggtt gtgttattat 38220
ccgccgatac gtctattaat ggaataccta actaccgaga tatgatatta cgaacctcgg 38280
gggatctatt acaaataccc gcattggctg tgtatgttga tttttacaca cggtcttatg 38340
atcagtttat aacctaaagt gtaacgttaa gttaacttag agcagacatc agacaggctg 38400
ccggggctaa acttacagaa gcaaataagg ctttggagga agtaactcat gttcgggcac 38460
acgaaacggc taaacttgca cttaaagaag gtgtcttcat tacattacca agcgaaggtt 38520
tattgattcg ggctatagag tattttacaa ctttcgatca taaacgattt ataggaacgg 38580
catatgaaag agttttacaa acaatggtag accgcgatct aaaggaggcc aacgcagagc 38640
ttgcacagtt tcgtatggtg tgtcaggcaa caaagaaccg tgcaatacaa attttacaaa 38700
acattgttga tacggccaat gccactgagc aacaagaaga cgtggatttc actaacctga 38760
agacgttatt aaaactaacc ccccctccca aaacaattgc attggccatt gatagatcta 38820
cttccgttca ggacattgtc acgcagtttg cattgctgtt agggcgtctg gaagaagaaa 38880
ctggtacgtt ggacattcag gcggttgact ggatgtacca agctcgcaat attattgact 38940
cccatccact aagtgtgcgt atagacggta ccggccccct gcatacttat aaagataggg 39000
tggataaact ttatgcgtta cgaactaaat tagatctcct acgacgacga atagaaaccg 39060
gtgaggttac gtgggacgat gcatggacaa catttaaaag agaaacgggg gatatgttgg 39120
catcggggga cacgtacgct acttccgtag atagtataaa ggcactccag gcatcggcgt 39180
ctgtggttga catgctttgt tccgaacccg aatttttttt attgcctgtg gaaacgaaaa 39240
accgtctcca aaaaaagcaa caggaacgta aaacggcgtt ggatgttgtg ttgcaaaaac 39300
aaagacagtt tgaagagacc gcgtctcgct tacgagcttt aattgaacgt attccaacgg 39360
agagtgacca tgacgttctt cgtatgttat tacgtgattt cgatcaattt acacatttgc 39420
ctatatggat aaaaacacag tatatgacat ttcgaaattt actcatggta cggttaggct 39480
tgtatgcaag ttatgctgag atttttccac ccgcgtctcc aaacggagta tttgctccta 39540
ttcccgccat gtcgggtgta tgtctagaag accaatcccg atgcattcgc gcgcgggtgg 39600
ccgcgtttat gggggaggcg tctgtggtgc aaacgtttag ggaagccaga tcttctatag 39660
acgctttgtt tggaaaaaat ttaacctttt acttggatac tgatggggtt ccacttcgat 39720
ataaagtgtg ttataaatca gttggggtta aacttggaac catgctatgc agtcagggtg 39780
gattatcttt acgaccggca cttcccgatg aaggtattgt ggaagaaact acactatcgg 39840
cattacgcgt ggccaatgag gtcaatgagc tacgcattga atacgaatcc gctataaaat 39900
ccgggttttc tgccttttcc acctttgtta ggcatcgcca cgccgaatgg ggtaaaacca 39960
acgcacgcag agccattgca gagatatacg ccggccttat aacaacaaca ttgacacgac 40020
aatacggggt tcattgggac aagcttattt attcttttga aaaacaccac ctaacttctg 40080
taatgggcaa tggactaact aaaccaatcc agagaagggg tgatgtacgc gtattagagt 40140
taaccctatc tgatattgta actattttgg ttgccacaac cccggtacat cttctcaatt 40200
ttgctagatt ggatttaatt aaacagcatg agtatatggc ccgtaccctc agacccgtaa 40260
tcgaggccgc atttagaggt cgtttactcg ttcgctcatt ggatggagac ccgaaaggca 40320
atgcccgggc cttttttaat gccgccccat ccaaacataa actcccgtta gctcttggat 40380
caaaccaaga tcctaccggc gggagaatat ttgcatttcg gatggcagat tggaaacttg 40440
ttaaaatgcc acagaaaata acggatcctt ttgcgccatg gcaactttcc cccccccccg 40500
gggtaaaggc caatgtcgat gcagttaccc gtataatggc aacagatcgt cttgcgacca 40560
ttactgtact tgggcgcatg tgtctcccgc caatttcctt agtgtcaatg tggaatacgc 40620
tgcaaccgga ggaattcgca tacagaacac aagatgatgt ggacattata gttgatgcga 40680
gactggattt gtcatccacg cttaatgcaa gatttgatac cgctcccagc aataccacgt 40740
tagagtggaa tacagaccgt aaagtaatta cagatgctta tattcaaacc ggggcaacga 40800
cagtttttac agtaacgggg gcggcaccaa ctcacgtttc taatgtaaca gcgtttgaca 40860
tagcaactac ggctatttta tttggggctc ctttggttat tgccatggaa cttacatccg 40920
ttttttcaca aaattccgga cttactttgg ggttaaaatt attcgattcc cggcatatgg 40980
ctacagattc gggtatatcc tcagccgtat ctcccgatat tgtttcttgg gggttacgtt 41040
tactgcatat ggatcctcac ccaattgaaa atgcatgttt aattgtccaa ctagaaaaac 41100
tgtccgcgct cattgcaaac aaacctctta caaacaatcc cccgtgttta ctgctattgg 41160
acgaacatat gaatccctct tatgttttat gggaacgaaa agactcgatt ccagctccgg 41220
attatgtggt cttttggggg ccagaatctc ttattgattt gccgtacatc gactccgatg 41280
aggactcttt cccctcgtgt cccgatgatc cattttactc gcaaattatt gccggttatg 41340
cgccccaagg ccccccaaac ctcgacacaa ctgattttta cccaacggag ccactattta 41400
agtctcccgt tcaagttgtt agaagttcca aatgtaaaaa aatgcccgtc cggcccgcgc 41460
agcccgcgca gcccgcgcag cccgcgcagc ccgcgcagac cgtccagccc gcgcagccca 41520
tagaaccggg cacacaaata gtggtacaaa attttaagaa accccaaagc gtaaaaacaa 41580
cccttagcca aaaagatatt cccttgtatg tggaaaccga atcagaaacg gctgtgctta 41640
tacctaagca attaaccacc tccattaaaa caaccgtttg taaaagtatt accccaccaa 41700
ataaccaatt gtcggattgg aaaaataatc cacagcaaaa ccaaacgtta aaccaagcgt 41760
tcagtaaacc aatacttgag attacctcca ttccgacaga tgactcgata tcttaccgga 41820
cttggattga aaaatcaaat caaacacaaa aacggcatca aaatgaccct cgaatgtata 41880
actccaaaac agtattccac cctgtaaata accaattacc ttcttgggtt gacacggcag 41940
ccgatgcccc ccaaacggac ctattgacaa actataaaac aagacagccg tcgccaaact 42000
ttccgcggga cgtacacaca tggggcgtat cttctaaccc gtttaactca ccgaacagag 42060
acctatatca aagtgatttt agtgaacctt ctgacggcta tagcagtgag agtgaaaatt 42120
ctatcgtact aagtctcgac gaacatcggt catgtcgcgt tcctaggcac gtacgcgttg 42180
ttaatgccga tgtagtcacc ggtcgacgtt atgtccgagg gaccgccttg ggagcactgg 42240
cactgttaag ccaggcatgt cggcgtatga tcgacaacgt tagatataca cgtaaacttt 42300
taatggacca cacggaagat atatttcaag gcctggggta tgttaaattg ttattagatg 42360
gaacatatat ataaagtagc gcctattaaa gaaaaaaaaa aaacaacgat tattttctgt 42420
gtatttttat ttacacccta cgacttcttg aagcgtttcc agattgtccc gtgtgtgaca 42480
aggtctgtcc cttacccccc tggggggtat tttgggttgg gggcggggta gactgtggca 42540
cgccttgggc cgcgggcggt gatccggttg ttggctggac agtgcttgac tgtgctccct 42600
gttgcggttg ttgtccagaa gaccccgaca ccacgtgttg ctgttgtcca acggatgccg 42660
acgtcgtttg aggtgggggg tgttgcgggg atgatcccga aaacgccaac gcggcgggct 42720
gttgtaaagc agactgatcg gcgctctgtg ttttttgcgg caatatagta ggccccgaga 42780
ttcccaaact catggatgga tttgggggtt gtggtcgtat aatacgcggg ttaaacgtac 42840
gttttaagcc aaccgttggt cttaaccatg tcatagggtc agtctcggca aacatggccg 42900
ttcggcgtat cgtatttgca ttatggttag cgcgtgcacg cgcggcactg gccgcggctc 42960
ccacggtgta aatgcttctg gcatcagcga tgtccacacg gtgaccaggt tgcaaaggtc 43020
cactggcgtt taaaagtcgt attaaagcaa cgggggtgta agccgcaatt gcttccaccg 43080
aaaatgtggt ggggttgctg ggatcaaaga ctacacgaga cgatgcgggt tgtgtcatcg 43140
tttattagtt tacgggacaa tcgataacag catacacgta catctgcgca ggatatgtac 43200
ggaaaggcaa tttatttcca gaaaagcacc gcccctaata caactaccag tacaattaca 43260
atgaacaggg catatgtcac gttagctacg ggtagagcaa gtttccagac acgcgtagtt 43320
tgggtatcgg gtaacgcagg tttaatgtca ctttgcattt gaacagacgt gtttggactt 43380
ccgttctcgg gtggggatct gaatgaaggc cgccagcgta tatattcatc caaattattg 43440
ccagtttcct tatacatgta tgcatccgtg gcgcgggcca taagtttaat ggtgcgagat 43500
ggatcttccg gtcccataaa acgaaaggat aactgaacat atggcattcg cacaaagcag 43560
ttcacccaca ttaaagcctg gagaggtcgg cggtcaatac ccccacctcg tttaattgat 43620
tccaaagcag ataggttgat accggtactt aacgttgaac taagaatcac gttattactg 43680
tcaatggaca cttcagccac tggtgcgtta gtcggacgaa aaaaaaaacc ttgaaatagc 43740
acagacaccc ccgtattttg aatttttatg taagggtcac aatctacttg cgcccaattc 43800
gccattaaac gcataatata ctctaccgga aaggcttcgg atacgttgtc ttcgccgtta 43860
aactgaaaaa cacaacgggc gggggggcgt tgtggatcaa atattggaag atccccatcg 43920
caacattgaa gagcgcttgg taccaccaac cgaatacgtt gtaaaagatt atctccgcaa 43980
cccctcctgc gttcactccg tacatacgtt ctccgtgaca tattgatcta aggttgcaaa 44040
ccaaggcaca cgcgtgaagt atttagacca tttatcgtgg gatataggag gagtttggag 44100
tgatccaccc cctgacgact tattaatgcg tttattttcc ccatgtatta agcatccttc 44160
aatatttcat gcaaatctag aaatttggcc atgactcccg caaagcgttc acggcgacgg 44220
gtcacgctgg cactatgttc acatggaaca acataagcag atttttctga atcgttactt 44280
tctttatgtt ttaaaacgga cgccaggcga ctggtaaatg atatataatt taattgagcg 44340
tcagttgtag gtagaattgc ttctatttcc gggggaatta aattttcaaa ccaaacggaa 44400
agagtaaagg tgctatcagc aggaaaatac tttgactcca gtgcatcgat atttaataga 44460
ttaacatcgg tgtctgtaat taaatcgcgg gccctcatcc cagagatgga tcgggtagaa 44520
tcagaagaac ccatggatgg attcgaatcg cccgtattct ccgaaaatac atcttctaat 44580
tccggatggt gttccgacgc attttccgat tcgtacatcg cttataatcc agcccttctg 44640
ctaaaaaacg atttgttatt ttcagaattg ttatttgcct cccacttaat aaatgttccc 44700
cgtgcaatag aaaacaacgt cacttatgag gcctcttcgg cggtaggtgt ggataatgaa 44760
atgacctcaa gtaccactga atttatagaa gaaattggag acgttttggc gttagacaga 44820
gcctgtttgg tctgcagaac gcttgatttg tataaacgta aatttggact gacaccggaa 44880
tgggttgcgg actacgccat gttatgtatg aaaagtctgg catccccgcc ctgtgcagtt 44940
gtcactttta gcgctgcctt tgaatttgtg tatcttatgg atcgttacta cctgtgccgt 45000
tataacgtta ctttggttgg gtcctttgcc aggcgcacgc tttccctgtt agatatacaa 45060
agacattttt ttttgcatgt atgttttcgt accgatggag ggttaccagg tatacgaccg 45120
ccccccggta aggaaatggc caacaaagta agatattcca attactcctt ttttgtacag 45180
gcggtagtta gggctgcatt actatcgatc agcacgtctc gtttagacga aaccgaaacg 45240
cgtaagtcat tttactttaa tcaggacgga ctgactggag gccctcaacc tttagcggcc 45300
gccttggcta attggaaaga ttgcgcgcgg atggttgact gttcatcatc ggaacatcgc 45360
acaagtggga tgattacctg cgcggaacgt gcattaaaag aggatataga gtttgaagat 45420
atattaatag acaaacttaa aaaatcgtct tacgtagaag cagcttgggg ttacgcagac 45480
ttggctttat tattactgag tggggttgct acttggaatg tagacgagcg tacaaattgt 45540
gctatagaaa ctcgcgttgg atgtgttaaa tcatactggc aggcgaaccg gattgaaaac 45600
tccagggacg ttccaaaaca attttccaaa tttacgagcg aggatgcctg tcccgaagta 45660
gcatttgggc ctattttgtt aactacctta aaaaacgcaa agtgccgtgg tcgcacgaat 45720
accgaatgca tgttatgttg tttattaacc atagggcact attggatcgc tttgcggcag 45780
tttaaaaggg atatattagc atactcagca aataacacaa gtttatttga ctgtatcgaa 45840
cctgtaatca atgcatggag cctagataac cccattaaac ttaaatttcc atttaatgat 45900
gagggtcgat tcataaccat tgtaaaagca gcaggttccg aggccgtata taaacattta 45960
ttttgcgatc tcctatgcgc tctctcggaa ttacagacaa accctaaaat tttatttgcc 46020
catcctacaa ccgcggataa ggaagtgttg gagttatata aagcccaact ggctgcacaa 46080
aacagatttg aaggtcgtgt atgtgctggc ctgtggacat tggcgtatgc atttaaagcc 46140
taccagattt ttccacgcaa accaaccgcc aatgccgcat tcatacgaga tggaggactt 46200
atgcttcgac gacatgcaat atcgctggtc tccctcgaac acaccctatc gaagtatgtc 46260
taggcgatat aaatccgtat ctcggagcgg gccttcgatg cgtgtacgct ccagaacgcc 46320
atgccgccgt caaaccattc gaggaaaact tatgtcaaag gagcggtctg tgtaccgcca 46380
ttattttaat tacatcgcaa ggtccccccc agaagaacta gctaccgtta gaggcttaat 46440
cgtgccaatt attaagacga cccctgtcac ccttccgttt aacttgggtc agacagtggc 46500
ggataactgc ctgtcgttat ccggaatggg ttatcattta ggtctcggag gttattgtcc 46560
gacatgcact gcatctggag aaccgcgtct atgtcgaacc gatcgggcgg ctctgatact 46620
agcatatgtt cagcagctta acaacatata cgaatatcgt gtgtttcttg catccatttt 46680
ggcgctatca gaccgagcca acatgcaagc agcgtccgct gaacccctat tgtcgagcgt 46740
attggcacaa ccggaattat tttttatgta tcatattatg agggaggggg gcatgcgaga 46800
tatacgcgta cttttttatc gtgatggaga tgccggaggg tttatgatgt atgttatatt 46860
tccggggaaa tctgttcacc tccattacag actaatcgat catatacagg ccgcgtgtcg 46920
ggggtataaa atagtcgcac acgtttggca gacaacattt ttactgtcgg tatgtcgcaa 46980
cccagaacaa caaacagaga ctgtggtgcc atccattgga acatcggacg tttactgtaa 47040
aatgtgtgac cttaactttg atggagaatt gcttttggaa tacaaaagac tctacgcatt 47100
atttgatgac tttgttcctc ctcggtgatt tcagcttcag tgttcatttt attatcccag 47160
cacggggcgt gtatacaaac aaagcctgcc gcctgcaagc ggtttagcat tttaacgtta 47220
acaactcgtg tctctggaat aaaacgtttt aaaagccgtt ctgtgagttt agtgtcgttt 47280
ccaaataacg ccttaaaagt tacactcgcc gtcccaatga gatgagaaaa ataatagtca 47340
atgtttaaag acagcccgtg tgatgttacg tgaatgggat cttccgctaa gtcagatatt 47400
attaacttac gctttgcttc cccacaccgt ttacctgcgg tattctgtaa aggatctcca 47460
cgtagcaaag ctacactttt tgcatcagcc tccacttcgt ctgtgggggc cacaataaca 47520
taagggatgc gttctcgaac gtttgggatt tgaccctgtc tcattactaa tttataatat 47580
actgttaagt gagccaagcg acggtttatg taggcggatg gtggacgact aagctcggcc 47640
gtcataacaa acttattaat atccaatttg ggtgatgtaa tctggcgatg tgcatctgca 47700
attatgcgtc caaacccggc catcccagac ggcatggccc gtctattcca ttcagcaatg 47760
gaaacacacg acgcctccgc cgcagcacgc gagacggtgt cgtcatataa caacagttct 47820
acaagtttgc gggcataatc gttaataaat tgacagttgt tttttctaac caagtcgact 47880
cccttcatta aaacctttcc gccgtaaatt accccaatgt actttttctt tgttataagc 47940
aaaagtttta taaaagtttt ttcacactcc aactttatag gaggacaaaa cagagccgtt 48000
gaaattatat gtgccatttt ctcgccgatt ttagctatcc cctcaacact aacacccttg 48060
aatcggataa acacagaatc cgtatctcca tatataacct ttacctcgta cgctttttgg 48120
gagagaacgc tactttcaat gtctggaaac gctgtaataa aacgttcaaa tgcggcccag 48180
ttattatgaa tataatctct ggtacttaat aacatttgac ggccaattgt agtgacagtg 48240
gccgctacgt ataaacatgg cagaaatccc tgcgcaactc cagtaaaacc gtacacggaa 48300
ttacaaacta cttttatcgc ggcttgttgt ttgtctaata acactgcttc atctgaagaa 48360
cttccgggta tgcgcgctct aatagccttg cgcatagcca accagtcttt taaaagaaca 48420
cccagcagac tttctcgaac gttagagcgc acaaaaaaaa gacgttttcc tccaactgta 48480
aaggtggcat aatcggatgg attcaaacgt ttaaccgtct caaaatttaa cgttagcgtg 48540
gtaaaacata agttatgggc ctgaattata cttggatata aacttgcaaa atccaatacg 48600
accaccggat cgatataaaa tcccgtatca gggtcaaaaa ccctggctcc tttatatcct 48660
acatttcgcc cacttgacgt accagtggga gaaacgctct cgtcttcatc catctcttcc 48720
tcaacatccc cgacatcggg aataacatcc ttatattcaa aagtagctgg gtatccccca 48780
tcgggtaaaa taaatcctcg agacgaagcc agtcctaata aacaggtgta aatcctaacc 48840
tgctgtccgt cgtaaatagc cttggttaaa gtaattctag ctagccttgc aaccgcggat 48900
aactcaaggt gtggtaaata tttaaaaaac agtttcccca caagagccga gtcttgtata 48960
caatattcac caataattcc tcgtgtattc ggtccactag cgtaatatcc cggaatgtct 49020
ttgtagggca aatctctctt ggactcattt agagcttcac gtgcaaccga atctaattta 49080
taactcgaga gttttaattt ttcagttgca attgcataca tatccagaga tatgagaccg 49140
ttgatcttta ccttgcttcg tcgctgaaat ccggatttgc caacatccca tatcttaaac 49200
agacccccac ggtttatact gccataacca tcaagcttga gactgtatat agaattaagt 49260
ttctccataa taaacgccca atcaaaatta acaatgttat aacctgtggc aaactcggga 49320
gcgtactgtt ttacgagggt cataaatgca attaatagct cgaattcact atcaaactcc 49380
agcacagtcg gctccggtaa ccccgcgtcc ttcatttctt gtacatacct ttgtggtaag 49440
tcacaagagc caagggaaaa cagtaaaatg tgttctaaag actgtcgagg gattgaatat 49500
aatagacaag aaatttggat tacaagatcc tccagatgtg ttgcatcggg aaacgccagc 49560
tcattagatc ctcctgattt acattcaata tcgaaacata acaacttgta gtcaggccat 49620
gagtcatcgt ttggtatagc ctgcagatta tccgacatgc agtcaatttc aacgtcgctt 49680
aacgttaatt ggcgacttgc cggtcgaact cgaacacgtt ccccatcaac tccaggtttt 49740
agttgatacc aaccaaaact aacaaagccg ggattatcca ttagaaaacg agtggtagcg 49800
tctacccgac cttcatactt tttcaactcc gggtgaaagt tatcacaaag ataatttgta 49860
aatttagatg agggagaata caccctgtaa aacgcacatg gctgtgtatc gtagtaataa 49920
acatctgtgc gctcaataac ctcaacgcga aagctttctg gagatgcgct tttaaacgag 49980
gtaccatgaa aagcgttctt gtctccattt aacgttgcat cattttgtgt tatcatagaa 50040
ctgcgtaaac actcggcaag taatacagat aactcgctac cggaacgtat gccacaagcg 50100
gtatccacct cggctttgtt tatataaaaa tattgacaga tgccgtatac atgaactgcc 50160
accctttttc cacatcggga catgccaagt aaagtaataa cggtaccaag cggtcgtgtt 50220
gcagttgcaa accgggatac atctccatta gacgcggctt ctgttgtttc gaoaatatca 50280
tatacatgga atgtgttaaa gcgggggtca aacttatccc cacgaaagtc gatttccccc 50340
caaatattca cgcgtctagg ccaggggctg gaacaacgaa aatccagaat cggaacttct 50400
tttccattac agtaaacttt aggcggtcga ctaagtgtac cgacgtgaac cccctttcgt 50460
tcttccatgg gcacatcttc atctaaacat ttaggggcca aaaattgaaa cgatgacatg 50520
gtagttttgt aactatgaag aaattctctg ttactaccgc gcccggttct tgggttatat 50580
ttaatccctg atgcttgggt taaaaaggga ttacaaaacc ccgttctgat cgccatttta 50640
tgttaacgat tgataatctt gtaaaaagcc agtgttactg agtaacacaa ccccacgccc 50700
ttctaataca taaagtgtaa tcacgtgatt tgttgtggtt tccgcatatg taatacccgt 50760
ttaaaagcct ctcttcttaa tgtatcgaca gactgggttt tgggtggtca tttgaccctg 50820
ccaacaaccc cccattatta cgagtacttc accaaaatgg aaaatactca gaagactgtg 50880
acagtgccca cggggcccct gggttacgtt tatgcgtgcc gggttgaaga tttggatctg 50940
gaggaaattt catttttggc cgctcgtagc acggactctg atttggcttt attacctttg 51000
atgcgtaatt tgaccgtgga aaaaactttt acatccagcc tggcggtggt ttctggagca 51060
cgcactacgg gtcttgccgg agctggtatt accttaaaac tcactaccag tcatttctat 51120
ccatctgtct ttgtctttca cggaggcaaa cacgttttac ccagctccgc ggccccaaat 51180
ctcacacgcg cgtgtaacgc ggctcgagaa cggtttgggt tttcacgctg ccaagggcct 51240
cctgttgacg gtgctgttga gacgaccggc gctgagatat gcacccgcct tggattagag 51300
ccagaaaata caatattata cttggtggtc acggcattgt ttaaggaagc cgtatttatg 51360
tgcaacgtgt ttctgcatta tggaggactc gatattgttc atattaacca tggggatgtt 51420
atacgtatac cgttatttcc ggtacaactt ttcatgcccg atgttaaccg tctggtaccc 51480
gacccattca acactcatca caggtctatc ggagagggtt ttgtataccc aacacccttt 51540
tataacaccg ggttgtgcca tttaatacat gactgtgtta ttgctcccat ggccgttgcc 51600
ttgcgcgtca gaaatgtaac tgccgtcgcc cgaggagcgg cccaccttgc ttttgatgaa 51660
aatcacgagg gggcagtact cccccctgac attacgtaca cgtattttca gtcctcttca 51720
agtggaacca ctaccgcccg tggagcgcgt cgaaacgatg tcaactccac gtctaagcct 51780
agcccatcgg gggggtttga aagacggttg gcgtctatta tggccgctga cacagccttg 51840
cacgcagaag ttatattcaa cactggaatt tacgaagaaa ctccaacaga tatcaaagaa 51900
tggccaatgt ttataggcat ggagggcact ttgccaaggc taaacgctct ggggtcatat 51960
accgctcgtg tggccggggt cattggtgcg atggttttca gcccaaattc tgcgttgtat 52020
ctaactgagg tggaggatag cgggatgacc gaagccaagg atgggggacc gggtccatca 52080
tttaatcgat tttaccagtt tgccggacct catttagctg cgaatcccca aacagatcga 52140
gatggccacg ttctatccag tcagtctacg ggttcatcaa acacagagtt tagcgtggat 52200
tatttggcac tcatttgtgg atttggagca cccctgttgg cgcgactgct tttttatcta 52260
gaacgctgtg acgctggtgc gtttacaggg ggtcacgggg atgcgttaaa atatgttacg 52320
gggacctttg actctgaaat tccatgtagt ttatgtgaaa aacacacgcg gccggtatgc 52380
gctcacacaa cagtacaccg acttagacaa cgcatgccgc gatttggaca agccacccgt 52440
caacctattg gggtgtttgg aacaatgaac agccaatata gcgactgcga tcctctagga 52500
aactatgctc catatttaat ccttcgaaaa cccggggatc aaacggaagc agcaaaggca 52560
accatgcagg acacttatag ggctacacta gaacgcttgt ttatcgatct agaacaagag 52620
cgactactgg atcgcggtgc cccatgttct tccgagggac tatcgtctgt cattgtggat 52680
catccaacgt ttcgtcgcat attagacaca ctgcgtgcgc gtatagaaca gacaacaaca 52740
caatttatga aagtgttggt tgagacccgc gattataaga tccgtgaagg attatccgaa 52800
gccacccatt caatggcgtt aacgtttgat ccatactcag gagcattttg tcccattacc 52860
aattttttag ttaaacgaac acacctagcc gtggtacaag acttagcatt aagccaatgt 52920
cattgtgtat tttacggaca gcaagttgag gggcggaact ttcgtaacca attccaacct 52980
gttttgcggc ggcgttttgt tgacctgttt aatggggggt ttatatcaac acgctctata 53040
accgtaacat tatctgaagg tcctgtatcc gccccaaatc cgacattggg acaagacgcg 53100
cccgcggggc gtacctttga tggggattta gcgcgcgtaa gcgtggaagt tattcgggat 53160
atacgagtta aaaatagggt cgttttttca ggtaactgta caaatctctc tgaggcagcc 53220
cgggcaaggc ttttaggcct tgcaagtgcg taccaacgcc aagaaaaaag agtggatatg 53280
ttacacgggg ccctagggtt tttgcttaaa cagtttcacg gcctgttatt tcctcggggt 53340
atgccaccaa acagtaaatc ccccaacccg cagtggtttt ggaccctgtt acaacgcaac 53400
cagatgccgg cagataaact tacacacgaa gagattacca ctattgcagc tgttaaacgg 53460
tttaccgagg aatatgcagc aataaacttt attaatctac ccccaacctg cataggagaa 53520
ttagcccagt tttatatggc aaatcttatt cttaaatact gcgatcattc acagtacctt 53580
ataaatacct taacttctat aattacgggt gccaggcgcc cgcgtgaccc atcatccgtt 53640
ttgcattgga ttcgtaaaga tgtcacgtcc gccgcggaca tagaaaccca agcaaaggcg 53700
cttcttgaaa aaacggaaaa cttaccggaa ttatggacta cggcttttac ttcaactcat 53760
ttagtccgcg cggccatgaa tcaacgtccc atggtcgttt taggaataag cattagtaaa 53820
tatcacggag cggcaggaaa caaccgcgtc tttcaggcag ggaattggag cggtttaaac 53880
gggggtaaaa atgtatgccc gctatttaca tttgatcgca ctcgccgttt tataatagca 53940
tgtcctagag gaggttttat ctgccccgta acaggtccct cgtcgggaaa tcgagaaacc 54000
accctatccg accaagttcg cggtataatt gtcagtggcg gggccatggt tcaattagcc 54060
atatacgcca cggttgtgcg tgcagtgggc gctcgagcac aacatatggc atttgacgac 54120
tggttaagtc ttacagacga tgagttttta gccagagact tggaggagtt acacgaccag 54180
attatccaaa ccctggaaac gccctggacc gtagaaggcg ctctagaagc agtaaagatt 54240
ctagatgaaa aaacgacagc gggagatggg gaaaccccca caaacctagc atttaatttt 54300
gattcttgtg aaccaagcca tgacaccaca tctaacgtat taaacatttc agggtcaaac 54360
atttcagggt caactgtccc tggtcttaaa cgaccccccg aagatgacga actctttgat 54420
cttagtggta ttcccataaa acatgggaac attacaatgg aaatgattta acctccctct 54480
ttatccaatt aaagcccaca cgcgggtgag tgtacgtaat aaacaagtca atattacata 54540
ttctgttgtg ttttcttttt ttgtgtgtag tccttaccca tatgacctgt aatatagtgt 54600
gtctccaacc attcagctta cagtccagtg gacagtaaca gcccgataac atggaattgg 54660
atattaatcg aacattgttg gttctactgg gtcaagttta tacgtacatc tttcaggttg 54720
aactgctacg tcgatgtgat ccaagggtgg cgtgtcgctt tttatatcgg ttagcggcta 54780
actgtttgac agttcgttat ttattaaagc tgtttctccg gggatttaat acccagctaa 54840
aatttggaaa cactcccacg gtttgtgcac tgcattgggc attatgttat gtaaagggag 54900
aaggtgagcg tttgtttgag ttgctacaac attttaaaac gcgttttgtt tatggtgaga 54960
ctaaagactc aaactgtatc aaagattact ttgtctcagc gtttaactta aaaacctgcc 55020
aatatcacca tgagctgtcg ttaacaacat acggaggtta cgtatcgagt gaaattcagt 55080
ttttacacga cattgagaat tttttaaaac agcttaatta ctgctatatt atcacgtctt 55140
ctcgtgaggc gctaaacaca ttggaaaccg tgacgcggtt tatgacagat actataggaa 55200
gcggtctaat accacccgtg gagttgtttg atccggcgca tccatgtgct atatgttttg 55260
aagaattatg tataacagct aaccaaggtg agaccttaca tcgtagatta ttaggatgta 55320
tctgcgatca cgttactaag caagttcggg ttaacgtgga tgttgacgat attattcggt 55380
gtttaccata tatccctgat gtaccggata tcaaacgtca atccgccgtt gaagcgttac 55440
gaacacttca aaccaagacg gtagtcaatc ccatgggagc aaagaacgat acgtttgacc 55500
aaacatacga aattgcgagc accatgcttg attcttataa tgtttttaaa cctgcccctc 55560
ggtgtatgta cgccatcagc gagcttaaat tctggttaac gtctaattcc actgaaggac 55620
cccaacgtac tttagacgtg tttgttgata atttggatgt attaaacgaa catgaaaaac 55680
acgcagaact tacagccgta acggttgagt tggcgttatt tggaaaaact cccatacact 55740
ttgatagggc gttttctgaa gaactcggat ctctggatgc aattgatagt attttggttg 55800
gcaatcgctc atcctcacca gacagtcaga tagaagcatt aattaaagcc tgttatgccc 55860
atcatctatc gtcgcctctc atgcgtcaca tttctaaccc gagtcatgat aacgaagccg 55920
ccttacgcca acttttagaa agagttgggt gtgaggatga tttaaccaaa gaggcgagtg 55980
acagcgctac agcatccgaa tgtgatctga acgatgatag tagcataact tttgctgttc 56040
atggatggga aaacctgtta tccaaagcaa aaattgacgc tgcggaaaga aaacgagtat 56100
atcttgaaca tctgtctaag cgctctctaa ccagcctcgg tagatgtatc cgcgaacagc 56160
gccaagagct agaaaaaaca ctcagggtaa acgtttatgg agaggcctta ttgcagacat 56220
ttgtttcgat gcaaaatggg tttggggcac gaaacgtgtt tttagctaag gtttcccagg 56280
cagggtgtat tatcgacaat cgcattcagg aagcggcctt tgatgcacat agatttataa 56340
ggaatacctt agttcgacat acagtagatg cggctatgtt acctgcactt acacataaat 56400
tttttgagtt ggtcaacggc ccattgttta atcacgatga acaccgtttt gcacaacccc 56460
ctaacaccgc cttatttttt accgtggaaa acgttggcct atttccgcac ttaaaagagg 56520
aattggcaaa gtttatgggc ggtgtcgttg gttccaactg gcttctcagt ccatttaggg 56580
gcttttattg cttttctggg gtagaaggcg ttacttttgc acagagactt gcctggaaat 56640
atattaggga gcttgtgttt gcaaccacac tattcacctc tgttttccat tgtggggagg 56700
tgcggttatg tcgcgttgac cgtctaggta aggatccacg cgggtgcacg tctcaaccta 56760
aaggtatagg cagttcccac ggacccttag acggcattta tttaacgtac gaagaaacat 56820
gtccccttgt ggctattatt caaagtggag aaacagggat cgaccagaat accgtcgtaa 56880
tctacgattc agacgttttt tctcttctat acaccctaat gcagcggctg gctccggatt 56940
caacggaccc ggcgttttca taacctccgt tacgggggtg tggttatgct ttttatgcat 57000
attttctatg tttgttacgg cggttgtgtc ggtctctcca agctcgtttt atgagagttt 57060
acaagtagag cccacacaat cagaagatat aacccggtct gctcatctgg gcgatggtga 57120
tgaaatcaga gaagctatac acaagtccca ggacgccgaa acaaaaccca cgttttacgt 57180
ctgcccaccg ccaacaggct cctcaatcgt acgattagaa ccaactcgga catgtccgga 57240
ttatcacctt ggtaaaaact ttacagaggg tattgctgtt gtttataaag aaaacattgc 57300
agcgtacaag tttaaggcga cggtatatta caaagatgtt atcgttagca cggcgtgggc 57360
cggaagttct tatacgcaaa ttactaatag atatgcggat agggtaccaa ttcccgtttc 57420
agagatcacg gacaccattg ataagtttgg caagtgttct tctaaagcaa cgtacgtacg 57480
aaataaccac aaagttgaag cctttaatga ggataaaaat ccacaggata tgcctctaat 57540
cgcatcaaaa tataattctg tgggatccaa agcatggcat actaccaatg acacgtacat 57600
ggttgccgga acccccggaa catataggac gggcacgtcg gtgaattgca tcattgagga 57660
agttgaagcc agatcaatat tcccttatga tagttttgga ctttccacgg gagatataat 57720
atacatgtcc ccgttttttg gcctacggga tggtgcatac agagaacatt ccaattatgc 57780
aatggatcgt tttcaccagt ttgagggtta tagacaaagg gatcttgaca ctagagcatt 57840
actggaacct gcagcgcgga actttttagt cacgcctcat ttaacggttg gttggaactg 57900
gaagccaaaa cgaacggaag tttgttcgct tgtcaagtgg cgtgaggttg aagacgtagt 57960
tcgcgatgag tatgcacaca attttcgctt tacaatgaaa acactttcta ccacgtttat 58020
aagtgaaaca aacgagttta atcttaacca aatccatctc agtcaatgtg taaaggagga 58080
agcccgggct attattaacc ggatctatac aaccagatac aactcatctc atgttagaac 58140
cggggatatc cagacctacc ttgccagagg ggggtttgtt gtggtgtttc aacccctgct 58200
gagcaattcc ctcgcccgtc tctatctcca agaattggtc cgtgaaaaca ctaatcattc 58260
accacaaaaa cacccgactc gaaataccag atcccgacga agcgtgccag ttgagttgcg 58320
tgccaataga acaataacaa ccacctcatc ggtggaattt gctatgctcc agtttacata 58380
tgaccacatt caagagcatg ttaatgaaat gttggcacgt atctcctcgt cgtggtgcca 58440
gctacaaaat cgcgaacgcg ccctttggag cggactattt ccaattaacc caagtgcttt 58500
agcgagcacc attttggatc aacgtgttaa agctcgtatt ctcggcgacg ttatctccgt 58560
ttctaattgt ccagaactgg gatcagatac acgcattata cttcaaaact ctatgagggt 58620
atctggtagt actacgcgtt gttatagccg tcctttaatt tcaatagtta gtttaaatgg 58680
gtccgggacg gtggagggcc agcttggaac agataacgag ttaattatgt ccagagatct 58740
gttagaacca tgcgtggcta atcacaagcg atattttcta tttgggcatc actacgtata 58800
ttatgaggat tatcgttacg tccgtgaaat cgcagtccat gatgtgggaa tgattagcac 58860
ttacgtagat ttaaacttaa cacttcttaa agatagagag tttatgccgc tgcaagtata 58920
tacaagagac gagctgcggg atacaggatt actagactac agtgaaattc aacgccgaaa 58980
tcaaatgcat tcgctgcgtt tttatgacat agacaaggtt gtgcaatatg atagcggaac 59040
ggccattatg cagggcatgg ctcagttttt ccagggactt gggaccgcgg gccaggccgt 59100
tggacatgtg gttcttgggg ccacgggagc gctgctttcc accgtacacg gatttaccac 59160
gtttttatct aacccatttg gggcattggc cgtgggatta ttggttttgg cgggactggt 59220
agcggccttt tttgcgtacc ggtacgtgct taaacttaaa acaagcccga tgaaggcatt 59280
atatccactc acaaccaagg ggttaaaaca gttaccggaa ggaatggatc cctttgccga 59340
gaaacccaac gctactgata ccccaataga agaaattggc gactcacaaa acactgaacc 59400
gtcggtaaat agcgggtttg atcccgataa atttcgagaa gcccaggaaa tgattaaata 59460
tatgacgtta gtatctgcgg ctgagcgcca agaatctaaa gcccgcaaaa aaaataagac 59520
tagcgccctt ttaacttcac gtcttaccgg ccttgcttta cgaaatcgcc gaggatactc 59580
ccgtgttcgc accgagaatg taacgggggt gtaaatagcc agggggtttg ttttaattta 59640
ttaataaaaa tgtgtattac gttactcatg tgtctccatt acgcatcaca gggggtattt 59700
atacccgata atatacaaaa cgcgttttgt acctctaccg cacccgatat cttaacgggg 59760
ttattatgga atcgtctaac attaacgcgc tacaacaacc gtcgtctatc gcacatcatc 59820
cgtccaaaca gtgcgcttca agtctcaatg aaacagtaaa agattctccc cccgcgattt 59880
atgaagatag gttagaacac acgccggtac aattaccccg cgacggtaca ccccgagacg 59940
tatgttctgt gggacagcta acctgtcgag catgtgcaac gaaacctttt cgccttaacc 60000
gcgacagcca atacgactac ttaaacacat gtccaggggg ccgtcatatt tcactggcac 60060
tggagattat aacgggtcga tgggtttgca tcccgcgtgt gtttccggat accccagagg 60120
aaaaatggat ggcgccatat attattccag accgagaaca accatcatca ggggatgaag 60180
attctgacac cgattaaatt taacttaaat aaaaccttac cacccataaa aacgccttct 60240
gtttgtttaa cacgacaccg cttaacaaaa aaaaaaaaac caaacacgcc ttttatgaat 60300
gtaatacttt tatttgttgg ttaacaccgc cccaccatca tctgatttgc aaacatatcg 60360
gcgtcgtctg ccgtggaccc ctgtattaaa ggggccttgg aactcgcctc cactgcattt 60420
acatcttgtc caactgtatc tgtatgtggg gtgcttgttg tattttggga tgagcataga 60480
cccgaaacgc tttgaagctg ttttaataaa atcgatattc gaggatcccg tgtcccctct 60540
ggtatatttg tatggtgcga caaaggcatt tgtgtcccat tttgtgattt tagctctgta 60600
acctcctgtt gcagttttgc cacaacccca gcaagctctt cgtgctgacc attagaaact 60660
ctgtgtctcc tctgccaata tgatggagaa actcgacgtc tccgatgcgt tatatacgtt 60720
ggttcaccgg gaaaatatat atttgaggga aactctccgt ccatttgaga ctccccacta 60780
taaaaagaat ccaattccct ttgatccatg ctcttgaaat cccgttttcc tggacgacgg 60840
acatcggttt tgtctggaaa atttacacac ggggtctgca agtcaatacc ccgttcggcg 60900
gccaatgcgt tcataaatgc ggacatttgc atttccaaac gattgggtgg tggatatccc 60960
ggaaacccgt acggtccccc gaagtgtccc ggagggcaac cataaccccc tgtattaggt 61020
gggaaggcag gcgggtgtgg agatccatat ggcccgacga tatactgtcc gttatttgga 61080
gctccaattg atacctgcgg atttttagtc tgcccggtta acagctgtga ataatacgcg 61140
gtaggtatca gtacaaattc ccctccggtt ggaacgcccg acgggggctg tggtgagata 61200
ttactagcgt tacctgctac agaagccata tcgctgtcgt tcctacacaa ctgcgtaacc 61260
tttaaatgcg gaacagtctt ttcacaatct tcatttgatt ccccaacacc caacgcgaga 61320
tcgtatatgg gcccgccggg gtggaatgtg gcgtttataa cacccgcgtt gggtaattta 61380
gactccaccc cattaacgtt ggttatccga gcaagtccat atccggtgct agcctgaaga 61440
taaacgtgac ccataattcc ggcttcgcgt ctacgttttg caaccacgtc ccatctatct 61500
cttaaaagca tattgttcac ggctgtggat aataacacct tggcgagttt atcttcgcta 61560
accttccata ctttatttaa acccgcgtag tctttaacca gcgacaataa ccgcgcttta 61620
ctttccatcg ataaaacccg gaatggttca attgaagatt ccggggtaca gtcataattg 61680
accactgttc caacgcgtct tccaacaaca cataacgcaa catgggtaaa aaaattaccg 61740
tctggtatct cattcgggga caatcgtttt gaagacaggg atacggaggg taagtaattt 61800
gtgaccaagt ataacgcacg ttctagcgga gataatacag aatctctatt tccaaaaaaa 61860
ttcgaatggg ccgcttcaaa cagcaccgca tgtagttgag ggcatctaac gatacccaaa 61920
aaaaaaggtc cgcgtatgtc ctcaatgatt gcgattactt cacccacgac acagtctttt 61980
cgatgatcga tgtttattgg tattttacta gtaggcggca aagcggaccg cacaatctct 62040
ggggtaatat ttaattcccc ttcgtccttt gaatataagg ctaaataccc agccacgtat 62100
aacgcttcac agttctcttc gtcagcttca gcagccatta taaacacccc acggaccgga 62160
tagtgaatac tcacggtgtg gaggcaaact gaggaatgac acccaaacag acaaaatata 62220
gaagatcata gtcactgtta acgttgaact gcgcaaggcg gcgactttct tccaatgccg 62280
cccttacacg cggttggtgc attaacattc caagtccccg ttcatattgc aacataacac 62340
tgtcatgtat tgataccacg gcggctatgg gtagggatgt aacattttgt cggcggtgtt 62400
ctaattccaa tgcaattaag cttatgagcc gatcttggta ctgtccagaa gaaatatcta 62460
ttacggttct tcctaaactt ccacgactaa gctgggtatg cgcgtctaaa caaagagcaa 62520
ctaatccagg aaacatttca gtcagctctg tggtccgatt taacgtatac agtggtgcta 62580
tatatcgttc acataaaaat tgaaagttat tattaccgct tttaaacttc ccatcaaacc 62640
ccgtcgctcc gcgcaagatt acattgttgg taggggttcc tgttgcttct gacacaatca 62700
aacccagttg aaaattattt tttagtttat ctccgtatac gttcccgttc cataataagc 62760
gccttaataa taataacgcc gtaatcgtgt caattgttaa ccttaataga gtttggtctt 62820
ccataagaaa cacgttttgg gcccgttcta aatacgccgc ggccgcctgt tgaatcttgt 62880
ccacatatgc ggtatgattg cgatcaataa tgtcattaac cccaggatta aactgtccag 62940
gtgcaggcgg taggacctgc aaccgtataa gcgcatccat aacagaatgt gacgttaagg 63000
cgccttgatc ataccgcccc ccacgagcat gaaactggtc gcgtggtaga cgatcatagc 63060
aaaattgata actgttttta ttttcgtgtg ttgtcatata attcacaaat gtctcagtat 63120
attccggtag gtgctctata aggttcccga aggacgaaac ttgaggttcg tggacactat 63180
tagatgtcct atacattaaa tataaacata ataccgcaca ctcgaacgcg gagtacgctc 63240
tatctccaac atacattctc ccggcggact gtagacatgt taccgttgtg ttcataaacg 63300
tacgggaaat gcgcccgtct ttacaatcaa ctccgcgtgc agctacgggc ctatctaaca 63360
caagccgttc ctgcagagta cgataccatg gcccgaaaac aatccctgga gagttattgc 63420
cccttgccct tcccaagtac accagggtga taaaatccac ttgaaagttt gtatcgtact 63480
gcaacggtgc atcatttttg gcaatctgta cctcggggtg tatagactca ttgcgtatta 63540
tttctgtacg tgtacattcc tcagattgtg catctgcttc ttccgcctcg gcagcagccg 63600
tctccaggga atccaaaacc ttggccatgc gcgttagttg ttcttcgagg ggctttaaac 63660
gacgatctat ttccgttggt aacgtaatcg tttccccgcg aaggttgtct aatgcggcaa 63720
cggccgccgc attttttaac gttaacgtat ttttttccaa atcgggattc atacgccctc 63780
ttaactcaaa cgcgggagcc gtccagtagt gtatggggaa gttgggggct ataaagttct 63840
tagtggtaga caaaaatatc ccacatttat tcggaaacga gatagatccg aacccatatc 63900
tcgccgtcat ggtgtctgca gcaaacaaag tcaactggcg tgaatataaa ccggtactgc 63960
tttaaaagct gttttcttac ccatgggaaa acatcccggt tatactttgt aaaattccac 64020
cacaagcacc taaagaaggc cttctaaggg gtaaatccac cccacaagct gcattttctt 64080
caaactttgt taaagcggaa cgatggcatg atttcgcacg ctttttcgca agagaacata 64140
cgtgaatttt ctttttgcat agacgtcttc gctctctaac ggaccttatc gggggggtat 64200
attccgctac attctccaaa tgcgacgcta gcataacaag gtttccatga atcacctttg 64260
ggggtaaccg agttacctgt aacaggttca gaccccgttg agatacaaac acaaggaggg 64320
gggtcaccat tatttcatca gatcccgtgg gtgtggtttc ctttattaaa gccatggtat 64380
ccctcagctg gcgcataccc tcgcaaaact ggtgatactt agtaggggta tgtatattag 64440
cgctaaaacg gcaagatttt aattccacta taaaacaaac ggtctttccg gcaccactgg 64500
attccgtttg tataatacaa acacaatcgg ggcgtcggcg tcccaaattt acttcaaacg 64560
acattgatat gcgtacagcc ctttgaacat ccacgtggga taacggcgac aggagttttg 64620
ccagcctcgg gttgaacgcg tccgcgaaac ctcgacgtac gttatcaata tcctttttga 64680
gtacatcgta aaaacgagtg tggcaacgtt gtcccaaacg aaaacacttg gcccgaattc 64740
gactagcgga catatttgaa gttccgtccc agaagataac ctaagacgcg tttgtctaca 64800
ataaacatgt caacggataa aaccgatgta aaaatgggcg ttttgcgtat ttatttggac 64860
ggggcgtatg gaattggaaa aacaaccgcc gccgaagaat ttttacacca ctttgcaata 64920
acaccaaacc ggatcttact cattggggag cccctgtcgt attggcgtaa ccttgcaggg 64980
gaggacgcca tttgcggaat ttacggaaca caaactcgcc gtcttaatgg agacgtttcg 65040
cctgaagacg cacaacgcct cacggctcat tttcagagcc tgttctgttc tccgcatgca 65100
attatgcatg cgaaaatctc ggcattgatg gacacaagta catcggatct cgtacaagta 65160
aataaggagc cgtataaaat tatgttatcc gagcgacacc caatcgcctc aactatatgt 65220
tttcccttgt ccagatactt agtgggagat atgtccccag cggcgcttcc tgggttattg 65280
tttacgcttc ccgctgaacc ccccgggacc aacttggtag tttgtaccgt ttcactcccc 65340
agtcatttat ccagagtaag caaacgggcc agaccgggag aaacggttaa tctgccgttt 65400
gttatggttc tgagaaatgt atatataatg cttattaata caattatatt tcttaaaact 65460
aacaactggc acgcgggctg gaacacactg tcattttgta atgatgtatt taaacagaaa 65520
ttacaaaaat ccgagtgtat aaaactacgc gaagtacctg ggattgaaga cacgttattc 65580
gccgtgctta aacttccgga gctttgcgga gagtttggaa atattctgcc gttatgggca 65640
tggggaatgg agaccctttc aaactgctca cgaagcatgt ctccgttcgt attatcgtta 65700
gaacagacac cccagcatgc ggcacaagaa ctaaaaactc tgctacccca gatgaccccg 65760
gcaaacatgt cctccggtgc atggaatata ttgaaagagc ttgttaatgc cgttcaggac 65820
aacacttcct aaatatacct agtatttacg tatgtaccag taaaaagatg atacacattg 65880
tcatactcgc gtgtacgtgt ttttcttttt tatatatgcg tcatttatta ccacatcctt 65940
taatcccgcc tttatctccc taaaacggag tggtaatatt aaaagccgcc aagcctgttg 66000
gtgggtgagg aggggtaaag gcacgctgtg tgcataacgt tgcggtgata ttgtagcgca 66060
agtaacagcg actatgtttg cgctagtttt agcggtggta attcttcctc tttggaccac 66120
ggctaataaa tcttacgtaa caccaacccc tgcgactcgc tctatcggac atatgtctgc 66180
tcttctacga gaatattccg accgtaatat gtctctgaaa ttagaagcct tttatcctac 66240
tggtttcgat gaagaactca ttaaatcact tcactgggga aatgatagaa aacacgtttt 66300
cttggttatt gttaaggtta accctacaac acacgaagga gacgtcgggc tggttatatt 66360
tccaaaatac ttgttatcgc cataccattt caaagcagaa catcgagcac cgtttcctgc 66420
tggacgtttt ggatttctta gtcaccctgt gacacccgac gtgagcttct ttgacagttc 66480
gtttgcgccg tatttaacta cgcaacatct tgttgcgttt actacgttcc caccaaaccc 66540
ccttgtatgg catttggaaa gagctgagac cgcagcaact gcagaaaggc cgtttggggt 66600
aagtctttta cccgctcgcc caacagtccc caagaatact attctggaac ataaagcgca 66660
ttttgctaca tgggatgccc ttgcccgaca tacttttttt tctgccgaag caattatcac 66720
caactcaacg ttgagaatac acgttcccct ttttgggtcg gtatggccaa ttcgatactg 66780
ggccaccggt tcggtgcttc tcacaagcga ctcgggtcgt gtggaagtaa atattggtgt 66840
aggatttatg agctcgctca tttctttatc ctctggacca ccgatagaat taattgttgt 66900
accacataca gtaaaactga acgcggttac aagcgacacc acatggttcc agctaaatcc 66960
accgggtccg gatccggggc catcttatcg agtttattta cttggacgtg ggttggatat 67020
gaatttttca aagcatgcta cggtcgatat atgcgcatat cccgaagaga gtttggatta 67080
ccgctatcat ttatccatgg cccacacgga ggctctgcgg atgacaacga aggcggatca 67140
acatgacata aacgaggaaa gctattacca tatcgccgca agaatagcca catcaatttt 67200
tgcgttgtcg gaaatgggcc gtaccacaga atattttctg ttagatgaga tcgtagatgt 67260
tcagtatcaa ttaaaattcc ttaattacat tttaatgcgg ataggagcag gagctcatcc 67320
caacactata tccggaacct cggatctgat ctttgccgat ccatcgcagc ttcatgacga 67380
actttcactt ctttttggtc aggtaaaacc cgcaaatgtc gattatttta tttcatatga 67440
tgaagcccgt gatcaactaa agaccgcata cgcgctttcc cgtggtcaag accatgtgaa 67500
tgcactttct ctcgccaggc gtgttataat gagcatatac aaggggctgc ttgtgaagca 67560
aaatttaaat gctacagaga ggcaggcttt attttttgcc tcaatgattt tattaaattt 67620
ccgcgaagga ctagaaaatt catctcgggt attagacggt cgcacaactt tgcttttaat 67680
gacatccatg tgtacggcag ctcacgccac gcaagcagca cttaacatac aagaaggcct 67740
ggcatactta aatccttcaa aacacatgtt tacaatacca aacgtataca gtccttgtat 67800
gggttccctt cgtacagacc tcacggaaga gattcatgtt atgaatctcc tgtcggcaat 67860
accaacacgc ccaggactta acgaggtatt gcatacccaa ctagacgaat ctgaaatatt 67920
cgacgcggca tttaaaacca tgatgatttt taccacatgg actgccaaag atttgcatat 67980
actccacacc catgtaccag aagtatttac gtgtcaagat gcagccgcgc gtaacggaga 68040
atatgtgctc attcttccag ctgtccaggg acacagttat gtgattacac gaaacaaacc 68100
tcaaaggggt ttggtatatt ccctggcaga tgtggatgta tataacccca tatccgttgt 68160
ttatttaagc agggatactt gcgtgtctga acatggtgtc atagagacgg tcgcactgcc 68220
ccatccggac aatttaaaag aatgtttgta ttgcggaagt gtttttctta ggtatctaac 68280
cacgggggcg attatggata taattattat tgacagcaaa gatacagaac gacaactagc 68340
cgctatggga aactccacaa ttccaccctt caatccagac atgcacgggg atgactctaa 68400
ggctgtgttg ttgtttccaa acggaactgt ggtaacgctt ctaggattcg aacgacgaca 68460
agccatacga atgtcgggac aataccttgg ggcctcttta ggaggggcgt ttctggcggt 68520
agtggggttt ggtattatcg gatggatgtt atgtggaaat tcccgccttc gagaatataa 68580
taaaatacct ctgacataaa aaacatgtat aataaaaagt cactataaac gtattctcta 68640
caatacttta ttcgcgaata atacacacta cctttgggtt tttttcccgt ccccaaatgg 68700
tgtttggtgc actctaccaa aaaatagagc gcctaaatat gctatataac gcctcccagc 68760
aaaatacggt tcaaaggcat tacccgatat tgtattgtag tacagggcaa tgggaattga 68820
tgatcccaat aaacggcata gacgcacagc gccgttatag caggggtctc cagagtacag 68880
ggtatctaag taccgggata tctcatactc atgcctttcc gtgacagaaa catcaaccgg 68940
aacagtatcc gataaaccaa ctcctgtttt tgcaaggcgt aaaattcgca caccttcctt 69000
ttttgcaaga tgtgacgttt ccttgtaaca gggaagctgg gggagtggta agaacaacaa 69060
agtttcagcc aacgtgccaa taaagcccac ttccctcaag aggctgtttg ctgtatccac 69120
aatggtccgt attaaatctt gagcaacttg atccgtgtca tcatcactgg gtaacgcgtt 69180
aacataacta cgcgttaaat cttcaataac ggcataacaa ttaaacgctt cccaccgaga 69240
cagtatatat tgaacaatca cgaaccgttg acaggacgtc agatcacgtc cgtaagcatg 69300
cccgaaaaat ggaagttccc cccgttcgcc atataccgca acaactgcag tatatatcgt 69360
ctcacgggct tcattaagtt catcttcaag tccaggccat tttctggctt taaatataac 69420
ctcgtccgca aaaaaaaccg cacatgataa cgcgcggata caatgagtag tggctttatg 69480
gcgaggatcc caaatgtcca ttacccgggg gatggtccta atctgtacaa agttacttag 69540
tgtaatatga tcggacttct tacgccgtct aggctgtttc tcagaatacg gttcacccga 69600
aatcggcaca tcatctgctt ttacgtcttc cgtaaccaca tcagcagcgc gccgactaac 69660
aattatactt gttttttcat cgtcgttact tccgttaagc gcgtctcgta tctcgggcgt 69720
cccgtcgaat aatccactca ctagctcctg caaactttct ggtaactcca acatacgcat 69780
atacaccagt gaaaaactgg cttcgtttgg tacgtacata aagccatttg tggtattaat 69840
ggcggtgggt gttggaaaca attttagctt attctcgcgc gtaacatcta cccccgccac 69900
caatgttaaa tgcgtcacgg ggagggacac gagataatct gcgagcgtag ggtcctccac 69960
ttcaacatca aatgttccgc aaaggtcgcg atccaccgcc cccgatcccg ctgcaagtaa 70020
ggccactcga tccaaaaaca cgcagttatt attggatgat accgcccatg tcttcccggt 70080
gcgattgagc tcacttcgaa cgtaactggc aacagatctg tcaccgggtc cgaccccgcg 70140
aacaacatgt ccaaattttg cgatctcgcc tccatgtttg cggggtatgg aaattaagca 70200
tcccccgcat ataaaatacg ccctggtagc acgctcgtta aaataaaacg ttacgccgtt 70260
ataagatacg gttgaatgat atggaaattc catattaaag cgtttatcgg aacattaacc 70320
tcgaacttgc cgtcccgtga tcgtgtgatc gccaacctta ggtccacacc gaatatgaga 70380
aatatataac tacacgcaaa cattcaaaac accgtggtat cattaacgtc atatgaaaag 70440
atccaatcaa tccaatcaac cacacctcct accgtttagc acgtcagcta tgtgacatgc 70500
tccaaacata cgtaaacatt tagagagggt gttataacag tctgtcaggc ggggtatatt 70560
ctacataata caaggatcgg ctttaacttt gtcaacattt ttactttgga ctataaactg 70620
cgactgaacg ttatgaaccc accccaagcc cgcgtctcgg aacagacaaa ggacttgctt 70680
agcgttatgg ttaaccagca ccccgaagag gacgcaaaag tgtgtaaatc cagtgataat 70740
tcaccgcttt ataacaccat ggttatgtta tcgtatgggg gtgatacgga cttactatta 70800
agctctgcat gtacccgcac atctaccgta aacaggtcgg cgtttacgca acactccgtg 70860
ttttatatta tatccacggt gttgattcaa ccaatatgtt gtatcttctt ttttttttac 70920
tataaagcga cacgctgtat gctcttattc acagccgggt tacttctgac gattctacat 70980
cactttcgac ttattattat gttattgtgt gtctacagaa atatacgatc agacctgcta 71040
cccttatcta catcccagca actgctgctt ggaattattg ttgtgactcg aacaatgcta 71100
ttttgtatta cggcgtatta tactcttttt atagacaccc gggtgttctt tttgattacc 71160
ggacacttgc aaagtgaggt tatttttcca gatagcgttt caaaaatact tcctgtgtcg 71220
tggggtccaa gtccagccgt gttactggta atggcggcag ttatttacgc tatggactgt 71280
ttggtggaca cggtatcctt tattgggcca agggtgtggg tccgtgttat gttaaaaaca 71340
tctatttcgt tttagtccat ttcaataaat gtactataat tgttcagtct aaaaataatg 71400
ttgggtattt ataattaccg cccccgtgtt acttggaaac acccatacat atgttccact 71460
ctacatcaaa cttctcgcag ttttcttgtt cccgcacacg tttacacgtc cggattcaag 71520
tcgcaacgct gctgacaaaa tgacaacggt ttcatgtccc gctaacgtga ttactacaac 71580
ggaatctgat cgtattgctg ggttatttaa catcccagcg gggatcattc caactggaaa 71640
tgtgctgtca accatagagg tgtgtgcaca ccgttgcatt tttgattttt ttaaacaaat 71700
acgatcagat gataacagcc tttactcggc tcaattcgat attcttttgg ggacatactg 71760
caatacatta aactttgtgc gttttctaga acttggactg tctgtcgctt gcatctgtac 71820
taaatttccg gagctggctt acgtgcgaga tggcgttatt caatttgagg tacaacaacc 71880
catgatagca cgtgatggcc cacatcccgt cgatcagcct gttcataatt atatggttaa 71940
gcggatacac aagcgttcgt taagcgctgc gtttgcaatt gcatcggaag cgttgagttt 72000
gttaagtaac acatatgtcg atgggacaga gattgactca tcgttacgta taagagctat 72060
ccaacagatg gctcgtaatt tacgcaccgt tttggactca tttgaacgag gcactgccga 72120
tcaacttctt ggtgttctat tggagaaagc cccaccgcta tcgctgcttt caccaattaa 72180
taaattccaa cccgagggac atctaaatcg tgttgcacgc gcggccctac tttcggacct 72240
caaacgtaga gtctgtgcgg atatgttttt tatgacccga cacgccaggg aacctaggct 72300
gatctctgcg tatctgtcgg atatggtttc gtgcacccaa ccatcggtga tggtatcacg 72360
aataactcat acaaacactc gcggacttca ggttgacggt gtgttggtaa caacagcaac 72420
cttaaaacgg caactattac agggaatttt acaaattgac gacaccgccg ctgacgtacc 72480
agtaacatat ggcgaaatgg ttctacaggg gacaaacttg gtaaccgccc ttgtgatggg 72540
aaaggccgtc cgcggaatgg atgatgtagc ccgccatctc cttgatataa ccgaccctaa 72600
cacgttaaac ataccgtcta tacccccaca atccaactcc gattcaacga cagctgggct 72660
tccggttaac gcccgtgttc ctgcggattt agtgattgtt ggggataaac ttgtattctt 72720
agaagcatta gaacggcggg tctaccaagc tacgcgcgtt gcctaccctc ttattggaaa 72780
tatagatatt acgtttatca tgccaatggg agtgtttcag gcaaactcca tggacagata 72840
tacacgacac gccggcgatt tttcaactgt atccgaacag gatccacgtc aatttccacc 72900
ccaagggatt tttttttata ataaagatgg gatattaaca cagttgactc ttcgtgatgc 72960
aatgggtacc atctgccaca gttcattgct tgatgtcgag gccacacttg ttgccctccg 73020
ccaacaacat ttagatcgtc agtgttattt tggtgtatac gtggccgagg gtacagagga 73080
cacattggat gttcaaatgg ggaggtttat ggaaacgtgg gcagatatga tgcctcatca 73140
ccctcattgg gtaaacgaac atttaacaat tctacagttt atagctccga gcaacccgcg 73200
tctaaggttt gaattaaacc ccgcctttga tttttttgtt gcaccggggg acgtagacct 73260
tcccggaccg cagcgtcccc cggaagccat gccaaccgtt aacgcaacat tacggattat 73320
caacggaaac attcccgtgc ctctatgtcc catttcattt cgagactgtc gcggaaccca 73380
actcggtttg ggaagacata caatgacccc ggcaaccatt aaagccgtaa aggatacatt 73440
tgaagaccgc gcatacccaa ctattttcta catgctagag gctgttattc atggaaacga 73500
aagaaacttc tgtgcgttac tgcgactgtt aacacagtgt attcgcgggt attgggagca 73560
atcccacagg gtggcatttg taaataactt tcacatgtta atgtacataa ctacatatct 73620
cggaaacggt gagcttcccg aagtctgtat taatatatat cgggatttac tgcagcatgt 73680
aagagcatta cgccaaacta taaccgattt tacaatacaa ggagagggcc ataacggcga 73740
gacctcggaa gcgctaaata acatccttac ggatgacacg tttattgcac ctattctatg 73800
ggattgtgat gcgttaatat accgtgatga agccgcccga gaccgactcc ccgcaattcg 73860
tgtaagcggg cgaaacggat accaagccct tcactttgtg gatatggccg ggcataactt 73920
ccaacgacgc gataatgtgt taatccacgg gagacccgtt cggggagaca cgggtcaggg 73980
tattcccatt actccacacc atgaccgtga atggggtatt ctctccaaga tttactacta 74040
tattgtcatt cctgcatttt cccgcggttc ctgttgtaca atgggcgtgc gttatgatcg 74100
cctataccct gcgttacagg cagttatcgt tccggaaatt cccgctgatg aagaagcccc 74160
aactacccca gaagatccaa gacaccctct tcacgcacac caactcgttc cgaactctct 74220
taacgtttac ttccataatg cacacctaac cgttgatggt gatgcattgc tcacactaca 74280
agagttaatg ggagatatgg ctgaacgaac gacggccatt ttagtatcaa gcgcccccga 74340
tgcgggagcc gccacggcaa caaccagaaa tatgagaata tatgacggag cgctttacca 74400
tggccttatt atgatggcat atcaggcgta cgatgaaacc attgcaacgg gtactttttt 74460
ttatcccgtt ccggtcaacc ctctgtttgc atgtccggaa catttggcat cattgcgtgg 74520
aatgacaaat gctaggcggg ttttggcaaa aatggtacca ccaatccctc cttttctggg 74580
agccaaccac cacgcaacta tacgccaacc cgttgcctac catgtaacgc atagtaagtc 74640
ggattttaat actcttacat attctcttct tggagggtat tttaagttta caccaatatc 74700
tcttacacat caactacgaa cgggatttca ccccgggatt gcctttaccg tagtgcgcca 74760
ggatcgcttt gccacagagc aacttttata tgccgagcgt gcttctgaat cgtactttgt 74820
cggacaaatc caagtacacc atcatgatgc tattgggggg gtaaacttta ccctaaccca 74880
acccagagct cacgtggacc tgggagtcgg gtatacagct gtatgtgcca cagcagccct 74940
gcgatgccct ctcacggata tgggcaatac tgcccaaaat cttttttttt cacgaggagg 75000
agtgccaatg ttacatgata acgttaccga atcgttgcgt cgtataacag catcgggggg 75060
tcgcttaaat cccaccgaac ccctacccat cttcggcgga ctacgtcctg ctacatcggc 75120
aggaattgca cgagggcaag cctctgtgtg tgagtttgtg gccatgccgg tgtccactga 75180
cctacaatat tttagaactg catgcaatcc tagaggtcga gcatctggaa tgttatatat 75240
gggtgaccgt gacgccgaca tagaggctat aatgtttgat cacacacaat cggatgttgc 75300
ttatacagat cgagcaactc ttaacccatg ggcatcacaa aaacattcat acggtgacag 75360
gctatacaac ggaacataca accttacagg cgcttctcct atctacagcc catgctttaa 75420
gttttttaca ccagcggagg ttaacactaa ttgtaataca ctggatcggc ttctaatgga 75480
ggcaaaggct gtggcgtcgc aaagctccac cgacactgaa tatcaattta aacgccctcc 75540
cggttctacc gaaatgacac aggatccgtg tggccttttt caagaagcat atccaccact 75600
atgctcaagc gatgcggcca tgttacgaac ggctcacgcg ggagaaaccg gggcagatga 75660
agttcactta gcccaatatc tgattcgaga cgcgtcgccc cttaggggat gtcttcctct 75720
tccgcgataa tttcaccacg cccacatacc cactcccaat aaaagccctg tagagcgcat 75780
tggcatctta cttgagattt ggatacgctc ggccgacttg gtctgtttca cgcttcctta 75840
aacaacatgg ctatgccatt tgagatagag gtattgttac caggagaact atccccggcg 75900
gaaacatctg cattacagaa atgtgaggga aaaattatta ccttctcaac cctgcgtcat 75960
cgagcttcac tggtggatat agcgctgtcg tcatattaca ttaacggtgc tccaccagac 76020
acgctctcgc tgttagaggc ataccgaatg cgattcgcgg cagttataac acgggtcatc 76080
ccgggaaagt tgttggcgca tgccattggc gtgggtactc ctacacccgg gttgtttatt 76140
caaaatacat cccccgttga tctttgtaat ggcgattaca tctgcttact tcctccggtt 76200
ttcgggtccg cagactcaat tcgcttggac tctgtaggac tggaaattgt tttcccttta 76260
accatccccc agaccttaat gcgagaaatc atcgccaaag tggttgcacg ggccgttgag 76320
cgcacggccg cgggtgctca aattttaccc cacgaagttc tacgaggcgc ggatgtcatt 76380
tgttacaatg gaaggcgtta tgaactcgaa acaaatttac aacatcggga cggatcggat 76440
gcggctattc gcacattggt tttaaatcta atgttttcca taaacgaggg atgtctgctt 76500
ttattggcgc tgattccaac tttgttagtc caaggagcac acgacggtta tgtaaattta 76560
ttgatacaaa cggccaattg cgttagagaa accggccagt taattaatat accgccaatg 76620
ccgcggattc aagacggcca tcgccgattt cccatatatg aaactatttc atcttggata 76680
tcaacatcat ctagactggg ggataccttg ggaactcgcg caattttacg cgtctgtgtg 76740
tttgatggac cctctactgt tcatccggga gaccgcacgg ccgtgattca agtgtaaaca 76800
ggtgttaata aaaacacaac cagtctagtt acatttcacg cgtcttgttt ttatttaata 76860
ggcataaaca cggaatccgg tatacatgaa ctgccaatat acacggacat aattaatgca 76920
accatcagat catctgacat tgttcccgtg gtacctttac ccgtgtaagt ttttgtgtct 76980
agattaccca taccgccttt aattacctct gtcaggttat ccaactgttt acatagatac 77040
tccacggggt ctacacctaa ctttactgtt agggatacaa gctcctgtga ggctattata 77100
tttccggagt taaatcgttt aacaaaatag tctacggccg gcgttttttg tttttgtaat 77160
aaaaaaaaag ggtacgccac gctacatccg ggaggtatgg aatgataaaa cagtaacact 77220
ggagcggaag atagcacgtt tcccttttcg aggacagcaa actgttgtgc tatagccaac 77280
gatatggcaa ctgcagaatc ctggctgctg tttccctcta tagaaacgtg tacgtttgta 77340
aatgtattgg ggtgtaaagc gagtatgtgg cctaagcatt gagtaacgca acgccctatc 77400
tcactggaag acgtgccagt taaagctcta agaaaaaagt gctccaatcc aaatataatc 77460
caatccgact tataacgacc aacaatcgct acaccagtac cagacgctcg tgtatttgag 77520
gtaaatgcag ggtctacgta aacgtacaac actgacgata atatagcaca attcgcaacg 77580
gttgacggcc gatataaaat aaacctctca cgggcagttt ttgtaaataa tggccggtca 77640
aaccccacac ccccagaatt ctgtttacgc ccacctacaa tttcctgcac gaaggagtcg 77700
gccataaata aatctgcagt gcgccgcatg gctccatcca ttgtgatgaa aaccggctta 77760
tttaatacat aacacgaaca agctgtgaca tcgctatgtg ctaaaacacg cggcatgtga 77820
tcgtcgcata catatgtaac aacgtttaac aactgatccg acgatccacg taagttatac 77880
aaaaaacttg tacttgcttt tccggtattt gttgatgaaa caaaaataat tttacaattg 77940
gtttgattta aaaatccgac tatagtttgt acagcatcag gtcgaataaa attagcttca 78000
tccacaaaca gaagattaaa atcttgacct cggataccct ggaacgatag aaagatatat 78060
agttacccca ccaaagttta aatgtatcct taaataccac gtacgtaaaa aatgtttgaa 78120
tacgtacata tttctttttt ttttccagta caaccatatc cggtgtataa tggaagccca 78180
tttggcaaat gaaaccaaac atgcactttg gcataatgat cacacaaaag gattactaca 78240
cgttgtgata cctaacgcgg ggcttattgc ggccggaata gatcccgcat tactgatttt 78300
aaagaaaccc ggacaacgct tcaaggttga agtacaaaca agatatcatg ctacaggtca 78360
atgcgaaccg tggtgtcaag ttttcgccgc gtacattccc gataacgcct taacaaatct 78420
cttaatacca aaaacggaac catttgtttc acacgttttt tcggccacgc ataattcagg 78480
gggattgatt ttatcattgc ctgtttatct tagccccggt ttattctttg atgcatttaa 78540
cgttgtagcg atacgaataa atactggaaa ccgcaagcac cgtgatattt gtattatgta 78600
tgcagaacta atcccaaacg gaacgcgtta ttttgctgat ggacaacggg tacttttatt 78660
atgcaaacag ctgattgcgt atatccgatg cacccctcgt cttgcatcgt ctataaaaat 78720
atacgcagag catatggtgg cagccatggg tgaatcacac acgtcaaatg gggacaatat 78780
tggacccgtt tcatccataa tcgatcttga tcgacagtta acttctggag gtattgatga 78840
ctcccctgct gaaacacgca tacaggaaaa taatcgggac gtccttgagc taataaaacg 78900
ggccgtaaac attgttaact ccaggcaccc cgtccgacct tctagttccc gcgttgcatc 78960
tgggttgctt caaagtgcaa agggccacgg agcgcaaact tccaacacag atccgatcaa 79020
taacggttcc tttgatggcg tccttgagcc gcctggacaa gggcgattta cgggaaagaa 79080
aaacaattcg tccgccagca tcccaccttt acaagacgtt ctattgttta ccccagcttc 79140
gacagaaccc caaagtctta tggaatggtt cgacatctgt tatgcccaat tagttagcgg 79200
ggacactcca gcagatttct ggaaacggcg tcccctatca attgtaccgc gacattacgc 79260
agaatccccc agtccgttga ttgtagtatc ttacaacgga tcctctgcct ggggaggacg 79320
tattaccgga agtccaattt tatatcactc tgcacaggct attattgatg ctgcgtgtat 79380
aaatgcccgg gttgacaatc cccaaagcct acatgtgaca gctcgccaag agctagtcgc 79440
gcgtttaccg tttttggcta acgtcctaaa taatcaaacc cccttacccg cctttaaacc 79500
aggcgccgaa atgtttttaa accaggtatt taaacaagcg tgtgtgacat cgctaaccca 79560
aggtcttata acggagttac aaacgaaccc gactctacaa caactcatgg aatatgatat 79620
tgcagattct tcccaaacgg ttattgatga aattgtagcc cgcacaccag acctgattca 79680
gactatagtt tcggtgttaa cggaaatgtc aatggatgcg ttttataaca gctccttgat 79740
gtatgcggtt ttggcgtatc tgtcatctgt atatacacga ccacaaggtg gggggtatat 79800
accctacctt cacgcttcct tcccatgctg gttaggtaat cgttctatat atttatttga 79860
ctattataat tcaggagggg aaatacttaa gctttccaag gtccccgttc ccgtagcctt 79920
agaaaaggtt ggtattggta attccacaca actgaggggt aaatttatac gcagcgcgga 79980
tattgttgat attggaattt gttctaagta tttacccggt caatgttacg cgtacatttg 80040
tctaggattt aaccagcaat tacaatccat tttagtttta ccggggggat ttgcggcatg 80100
tttttgtatt accgataccc tacaggcagc actacctgca tcgttaatcg gacctattct 80160
agacagattc tgcttctcta ttcccaaccc ccataaataa attagtgtca ctataaaaac 80220
ataacaccag aatctcttca tatgtaattt tacgtcattt ctcccgtttc caccccctct 80280
taaaatataa aataaccggg tgggtggcattaaacccaca agtacccggg cggcaatccg 80340
ctagactgtt tttctgctca tggaattaca acgcatattt ccgctgtaca ccgctacggg 80400
tgcagcgcgc aaattaaccc ccgaggcagt tcagagactc tgcgatgcat taacgctgga 80460
tatgggatta tggaagtcca tcctgaccga tccccgggtg aaaataatgc gatcaactgc 80520
ttttataact ttaaggatcg ctccgtttat cccccttcaa acggatacta ctaatattgc 80580
cgttgttgta gccacaattt acatcacgcg cccacgtcag atgaacttac ctccgaagac 80640
ttttcatgta attgtaaatt ttaattacga ggtctcgtac gcaatgacgg cgactttaag 80700
aatttatccg gttgaaaaca tagaccatgt ttttggagca acgtttaaga acccgatcgc 80760
gtaccccctt ccaacatcta ttccggatcc tcgagcagat cccacccccg cagatcttac 80820
accaacgcca aacttaagca actacttaca acccccgcgg cttccgaaaa atccatacgc 80880
atgtaaagtt atttctccgg gagtgtggtg gtcagacgaa cgaaggcgtt tatatgtact 80940
ggctatggaa cctaatttaa tagggctatg tcccgccgga tggcatgctc ggatacttgg 81000
ctctgtatta aatcgactcc tcagccatgc ggacggatgt gatgaatgta atcatagagt 81060
tcacgtgggg gcactgtatg cgttacccca tgtcacaaat catgcggaag gttgtgtgtg 81120
ttgggctccg tgtatgtgga gaaaggccgg tcagcgggaa ttaaaagtgg aggtagacat 81180
tggcgccacg caggttcttt ttgtagatgt caccacctgc attcgaatta cgagtactaa 81240
aaatcctcgc attaccgcaa atcttggcga cgttatagcg ggaaccaacg ccagtggtct 81300
ctctgtacca gtaaattcat ctgggtggca gctttatatg tttggagaaa cattaagccg 81360
ggctattatt aacggctgtg gtctgcttca gcgaatttgc ttccccgaga cacaaagatt 81420
atcgggtgaa ccggaaccta caaccaccta gtatacctta actcaaccgc cgttgtggaa 81480
aggtatatgt caacatttac agtaatatat taaaggttaa atttataaaa cactcacgtt 81540
tgtgttgtga cttgacgcga acaccgctgt gctgtaagac ccgtcggtaa atgaaaacgt 81600
aatagattcg ccttttacat gatccacgta atttgcccca aaccactgtt ccaggcgaga 81660
cttgataccc tcaaacacgg gttccgttgc tttgcgtata tgagccgtat aacccacttt 81720
aattcctcta aacgtggcca ttactaaagc tattaatggt acaagaaacc atgttttccc 81780
atgtctacgt ggtaccaaaa acacagttga tttttgtttg aagtgttcta aaacactgtc 81840
agaaacactt ggcgtgttaa acactgtacg cagaaagcag tcaactctgt cggcatgatc 81900
gcccaatagc accgatgaaa taaaatgcgt ggtgtgcatg aggatcattt tttgaaacag 81960
ttccaacgtc cccttatatc tgccatagat tggaacgtca acctttgcgc gtttgccatg 82020
acttccacac tcttcaatac tctcaaaaga tgtttccaca aggtacgaaa accgttgtgt 82080
aaaggtagac aactgacaga aactatccga cagagaaaac gcgcgaaatg tgttcataac 82140
accgctatac gcatttcgat gaggtgctgc ttcttccggt gaatattcat aaaactgtac 82200
actactgaca gcctttttta attcagggct tacgtttgca tttaccgaat atcgccatgg 82260
tttcaaaact acattggggg tacagttgta ccctgttgac gatagaaacg cgccaaacat 82320
tgcccgtcga gcagtagccg agaacagtgg aatatattca caacagttgt gaagcgttcc 82380
aattccggga ataacggcct gatgacgtcg ggttacatct atagcaaaat tcagaaacgg 82440
gatttgggtt gcgtttccca gagacccttg ccgcgtggaa cacggggtag gggactccaa 82500
cgtcccaaag cgttcatccc tacgacgctt tagacgttca aaatatctta cagattcttc 82560
accaagcgta cgaccaaaca ttatcaatga catttaacat caattcacgg aatccgcctc 82620
atctcttgta agcagtaaaa caggaagccg cgtcatctta cgtactcgtt acgtatatat 82680
cataaacatt ttcagggccg cattcattca ctttggtcat gtcaggccac actccaacct 82740
acgcttctca taggcgtaac cgtgtcaaac tagttgaggc gcataaccgc gcggggttat 82800
ttaaagaacg gaccctcgat ctaatccgtg ggggtgcgag tgtacaagat ccagcatttg 82860
tgtatgcctt tactgctgca aaagaggcct gcgccgattt aaataaccag ctccgctctg 82920
cagctcgcat agcttcagtt gaacagaaga ttcgtgatat acaatccaag gttgaggaac 82980
aaacaagtat tcaacagatt ttaaatacaa acagacgcta tatagcaccc gattttattc 83040
gcggtttgga taaaacagaa gacgataata ccgataatat agacagactg gaagacgcgg 83100
taggaccgaa catcgaacac gaaaatcata cttggtttgg agaagacgac gaagcgttac 83160
ttacacaatg gatgctgacg acacaccccc caacctccaa atatctccaa ctgcaggacc 83220
tttgcgttcc caccacaata ccgacggaca tgaaccaaat gcaaccgcag ccgatcagca 83280
agaacgagaa tccaccaacc ccacacacgg atgtgtaaat catccatggg ccaatccgtc 83340
aactgcaaca tgcatggaat caccagaacg atcacaacag acaagcttat ttttattaaa 83400
gcacggctta acgagagatc caatacatca acgcgaaagg gtggacgttt ttccacaatt 83460
taacaaaccc ccatgggttt ttagaatttc caaattatcc cgtttaattg tacccatctt 83520
cacgctcaat gaacagttat gtttttctaa attacagatt cgagatagac ccaggtttgc 83580
gggacgggga acgtatgggc gtgttcatat atacccatcg tcaaaaatag ctgtaaaaac 83640
catggacagt cgtgttttta atagagagtt aattaacgcg attttagcga gtgagggttc 83700
tatacgagca ggggaaaggc taggtatttc tagcatagtt tgccttttag gtttttcgtt 83760
acaaaccaaa cagctactgt ttccggcata cgacatggat atggatgaat acattgttcg 83820
cctgtccaga cggttgacaa tacctgatca catagacaga aaaattgccc atgtattttt 83880
agatttggct caagcgttga cgtttttaaa tcgaacgtgc ggcctgaccc acctagatgt 83940
gaaatgtggc aatatttttc ttaacgtcga caactttgcc tcgttggaaa taaccacagc 84000
agtaatcgga gactatagcc tagtaacatt aaatacgtat tccctttgta ctcgagcgat 84060
atttgaagtt ggaaatccat cccacccgga gcacgtacta cgcgtacccc gggatgcatc 84120
gcagatgtca tttcgtttgg tgttgagtca tggaacaaac caaccccctg aaatcttgct 84180
tgattatatt aatggaacgg gccttactaa atatactgga accttgcccc aaagagttgg 84240
acttgcgatt gatctttatg cattgggcca agcactctta gaagttatcc tgctaggacg 84300
tcttcccgga caactgccca tttcagtaca tcggaccccg cattatcact actacggtca 84360
taagttatca ccagatttgg cgcttgatac gctggcatat cgatgtgtcc tggcgccata 84420
tatactccca tctgacatcc ccggggactt aaattataat ccctttatac acgccggaga 84480
gctgaacacc cgtatttccc ggaattcttt acgccggata ttccagtgtc acgcagtgcg 84540
ttacggcgta acgcactcaa agcttttcga aggcatacgc attccggcct cattataccc 84600
agccactgtt gttacatcgt tgttgtgtca cgataattca gaaatacgct cggatcaccc 84660
tttattatgg cacgatcggg attggatagg atcgacataa gcccccagcc agccaaaaaa 84720
attgcccgtg tgggaggtct acagcaccct tttgtaaaaa cggatattaa cacgattaac 84780
gttgaacacc attttataga cacgctacag aagacatcac cgaacatgga ctgtcgcggg 84840
atgacagcgg gtatttttat tcgtttatcc cacatgtata aaattctaac aactctggag 84900
tctccaaatg atgtaaccta cacaacaccc ggttctacca acgcactgtt ctttaagacg 84960
tccacacagc ctcaggagcc gcgtccggaa gagttagcat ccaaattaac ccaagacgac 85020
attaaacgta ttctattaac aatagaatcg gagactcgtg gtcagggcga caatgccatt 85080
tggacactac tcagacgaaa tttaatcacc gcatcaactc ttaaatggag tgtatctgga 85140
cccgtcattc cacctcagtg gttttaccac cataacacta cagacacata cggtgatgcg 85200
gcggcaatgg cgtttggaaa aaccaacgaa ccggcggcac gagcgatagt tgaagcattg 85260
tttatagatc cggctgatat ccgtactcct gatcatttaa cgccagaagc tacaactaag 85320
ttttttaatt ttgacatgct caataccaaa tctccaagtc tccttgtggg tacaccaaga 85380
atcggaacgt atgaatgtgg acttttaatc gacgttcgaa cgggacttat aggcgcgtcg 85440
ttggacgttc ttgtatgtga cagggaccct ttaactggca ccctaaatcc ccaccctgca 85500
gaaaccgaca tttcattttt tgaaattaaa tgtcgtgcta aatacctctt tgatccagat 85560
gacaaaaata acccgctcgg tcggacgtac accacgttaa taaatagacc tacaatggca 85620
aatctacggg actttttata tactataaaa aacccatgtg taagcttctt tggaccctca 85680
gcaaacccaa gtacacgcga ggccttaata acggatcacg ttgaatggaa acgtttagga 85740
tttaaaggtg ggagggccct tacagaactc gacgcccatc atttgggcct caatcggaca 85800
atctcatccc gagtgtgggt atttaatgat ccggacatac aaaaggggac aattacaacc 85860
attgcatggg ccactggaga tacggctctt caaattcctg tatttgccaa tccgcggcac 85920
gctaacttta aacaaattgc cgtacaaacc tatgtattat ccggttactt tccagcgcta 85980
aaactacggc ccttccttgt cacctttata ggacgtgtgc gccgaccaca cgaggtggga 86040
gtcccattgc gcgtcgatac acaagcggct gccatttacg aatataactg gccgactatc 86100
ccaccccact gtgcggttcc ggttatagcc gttctaacgc ctatcgaagt tgatgtgcct 86160
agagtgacac aaatacttaa agacacagga aacaacgcga ttacatcagc attgcggtca 86220
ttgcgatggg acaatcttca tccagcggtc gaggaggaat ctgtggattg tgcaaacggt 86280
acaacgagct tgttacgtgc aacggagaaa ccgttgcttt gaactcagag ttctttgaag 86340
actttgactt tgatgagaat gtaacagagg acgccgataa atccacacaa cgccgcccac 86400
gagtgatcga tgtaacacca aaacgaaaac cttcgggaaa gagctcccat tccaaatgcg 86460
caaaatgtta aaccctgata aaccctgata aacgttctaa taaaaacatc aaatcatggt 86520
tggttactgt gaatgtttgt tttattgctt gggggtttac aagtacaacc cacgctactc 86580
ccacccactg tttgatcgct cgtataacag ctcatcctcg cggtccgttt catatgttga 86640
gtcattttca tagacgtagc cgtagccttg tgatgggtaa tttgtgcggc gagaatttct 86700
atgtgcaggt tttacttttc gtatgtatcc ccgtacccgc tcgggtactc ttcttacggc 86760
accgtagaac cgactgcgtt tctgtcgatg atacacatat gcacgcatca atctgagaag 86820
caacatgaca acggaaaaca cggccaggca agccaaggtt ccccgagttg tgggaattaa 86880
ccgtggagat tgaaccgata tagggtcata taatcggtcc atatacgagt gcgcggcggt 86940
tcccaacgta gcacaggcca cgagcgttcc cagggacggt cctattaaca cgtgtatata 87000
atgcgccaaa attaattctg atactataag atatacaact gacaatgtac taaatgtaga 87060
catggccacg gacaccgatg accacagtcc cgtatgtaga tgattcgcca ccacaagttc 87120
cagcattaat gatacaaata ggatacatat cgccatcaac gcagccatca aattcacgaa 87180
cactgcgcgc gtaggccccg caaggcgata taaaaagacg ctctgctgtc gtaaatttgc 87240
gaccgctttt atgttcgttt cgtccaattt tccgcgtcca caaaaatacg ttgtaaatat 87300
tacacttgtc gcaaaatgtc caagatataa tgtagcagcc acgccgattt gcttgtaagc 87360
taataataac acaacggcgt ttaataacca caatgacaaa agaccccaaa aaagtgttgt 87420
gggatctaca actaaccatg caacaccgga gctttgccgg acacgttgat ttttcgtttc 87480
tcggtgtata atcgcggccg tgatcagtgt atataccgcc atggccattg ccgttaaagc 87540
cgtgtagtaa gtaaatgcca caacgctatg tggttccaaa aacaaaaccg gggcgctgta 87600
tccacctcta tttccggacc ataccccccc atctagggtg gcgttaaata actcataatc 87660
aactacggca gcataaaaac aagggatccc ggtatattca gaagaggcgg caattaacgt 87720
agccaggagc attaccgcac ccaaagtgaa catcatcacc tgaattatcc aaattcgcca 87780
attaagcgta tccatttgat gatctaacgc ttccacctcg ggtgtcgtgg tgtcgtacgg 87840
cgagactttt tcagaacgcg gccccttctt ttgagttccc atgtctccca acaccgggga 87900
gagcaacgcc gccgtctatg cgtccagtac acagctcgcg cgggcgttat atggagggga 87960
tctggtttcg tggattaaac acacccaccc gggaattagc ctggaactgc aattggatgt 88020
tccagtaaaa ctaataaaac ctggtatgtc acaaactcgc ccggtaaccg tcgtacgtgc 88080
ccctatgggc tctggtaaaa caacagcctt gcttgagtgg cttcaacacg cgttaaaggc 88140
agatattagc gtactggttg tctcatgtcg ccgtagcttt acccagacgt tgattcaacg 88200
gtttaacgat gcaggcctct ccggattcgt aacatatttg acatccgaga catatattat 88260
gggttttaaa cgtttgattg tgcaacttga aagcctacac cgcgtatcca gcgaagctat 88320
cgacagctac gacgtattaa tactggatga ggtaatgtca gtgattggac aattatactc 88380
ccccacaatg agacgtcttt ccgcggttga tagcctatta tatcgtcttt taaatcgctg 88440
ttctcaaatt atcgcgatgg atgctacagt aaactcgcag tttattgatt taatctccgg 88500
attgcgtgga gatgaaaaca tacacacaat tgtgtgtaca tacgcgggag ttgggttctc 88560
cggaagaact tgcacgatcc tgcgtgatat gggcatcgac acgcttgtgc gagtcattaa 88620
acgatctcct gaacacgagg atgtacgtac catacaccaa ctacgtggaa cattttttga 88680
cgaactagca ctacgattac aatgtgggca taacatctgt atattttcat caactttatc 88740
gttttcggag ctagttgctc agttttgtgc aatatttaca gactctattc ttattttaaa 88800
ctcaactcgg cccctatgta atgtaaacga atggaaacat tttcgcgtgt tggtgtacac 88860
taccgtcgtg accgttggat tgagttttga catggctcat tttcatagca tgtttgctta 88920
cataaagcca atgtcatatg ggccggatat ggtatcggtc taccagtcat tagggcgtgt 88980
acgtttattg ctacttaatg aagttttgat gtacgtcgat ggctcaagga ccagatgcgg 89040
acccctgttc tcgccaatgt tactaaactt taccatcgca aataaatttc aatggtttcc 89100
tacacacacc caaataacta acaaactgtg ctgtgcattt aggcaacgat gtgcaaatgc 89160
atttacacgc tcgaacaccc atctcttctc aagatttaaa tacaaacacc ttttcgagag 89220
atgctctctt tggagtttag ccgatagcat taatatctta caaactcttt tggcctctaa 89280
ccaaattttg gttgtattgg atggcatggg tccaataacg gacgtttccc cagttcaatt 89340
ttgtgcattt atacacgatc tcagacatag cgctaacgcc gtagcttcct gtatgcgttc 89400
tcttagacag gacaatgaca gctgcttgac cgattttggc ccttccggat ttatggccga 89460
taacattacc gcgtttatgg aaaagtatct tatggagtca attaataccg aagaacaaat 89520
taaagtattt aaagcccttg catgtccaat agaacagcct agactagtca atacggcaat 89580
attgggggcg tgtatacgaa tacctgaagc gttggaagca tttgacgtat ttcaaaaaat 89640
atacacgcac tacgcttccg gttggtttcc cgtcctggac aaaaccgggg aatttagcat 89700
cgcgactata actaccgccc caaatttaac cacacattgg gagctgtttc gccgttgtgc 89760
ctatattgca aaaacactca agtggaatcc gtccaccgaa ggctgtgtaa cacaagtttt 89820
ggatacggac attaatacac ttttcaatca acacggggat tcgctggctc aactaatatt 89880
tgaggttatg cgctgtaacg ttactgacgc taagattata ttaaaccgcc cggtttggcg 89940
aacaaccgga ttcttagatg gatgccataa tcaatgcttc cgtccaatcc ctacaaaaca 90000
cgaatataac attgctctat ttcgtttaat ttgggaacaa ttatttggcg cccgcgtaac 90060
taaaagtacc cagacctttc cgggaagtac tcgtgtgaaa aacctaaaaa aaaaagatct 90120
agaaacttta cttgattcaa ttaacgtgga tcgttctgca tgtcgtacct accgccagtt 90180
gtataacctg cttatgagcc agcgccattc gttctctcaa cagcgttaca aaattactgc 90240
ccccgcttgg gcacgccacg tgtattttca agcacatcaa atgcacttgg ccccgcatgc 90300
cgaagccatg ctacaattag cgctatcgga actgtccccg ggatcgtggc cgcggataaa 90360
cggggcggta aattttgaaa gtttataacc cgttaatacc atatatggac atccataggg 90420
ggggttacat aaatactaag cctctgtaca acacaaaggg cctctaacaa tgcactgaac 90480
cacaaccaag ctatggacgc aacgcagatt accttggtta gagaaagcgg acacatttgt 90540
gccgcaagca tatacacatc ctggacacag tccggacaat taacacagaa cggtctttcc 90600
gtgttatact acttattatg caaaaactca tgtgggaaat acgtccctaa gtttgccgaa 90660
attaccgtac aacaagagga tttatgtcgc tactccaggc atggggggag tgtttctgcg 90720
gcaacgtttg cgtctatctg cagggcggcg tcctcggctg cgttagacgc ctggcccctt 90780
gaaccactgg gtaacgcaga cacctggcgt tgtctccatg gcactgccct ggccacttta 90840
cggcgcgtat tagggtttaa atcgttttat tcgccagtaa cattcgagac tgatacgaat 90900
acaggtcttc tgttaaaaac aatccccgat gaacacgcgt tgaataatga caacacgcca 90960
tctaccggag tattgagggc taattttccc gtggccattg atgtttcagc agtcagcgca 91020
tgtaacgccc acacgcaagg tacgtcgcta gcctacgccc gcctgaccgc acttaaatct 91080
aacggtgaca cccagcaaca aacaccttta gacgtggagg taattacacc aaaggcctac 91140
atacgtcgga aatataagtc tacgttttcc ccccctatag agcgggaagg ccaaacctcc 91200
gatttgttta accttgaaga acgccgcttg gttcttagtg gcaatcgcgc aattgtggta 91260
agggtactct taccgtgtta ttttgactgt ttaacaacgg attccaccgt tacatcttcc 91320
ctttcaatat tagcaacata tagactgtgg tacgcggcgg cgtttggaaa acccggggtt 91380
gtccgtccaa tctttgcgta tttaggcccg gaactcaatc cgaagggtga agacagagac 91440
tacttttgta ctgtcggatt tcccggatgg accactcttc ggacacaaac tccagccgtc 91500
gaatctattc gcacggctac ggagatgtac atggaaacgg atgggttgtg gccagtaacc 91560
ggtattcagg cctttcatta tctagccccc tggggacagc atcccccctt acctccgcgg 91620
gtgcaggatc ttattgggca aatccctcaa gatactggac atgcagatgc aactgtcaat 91680
tgggacgcgg gccggatatc taccgtcttc aaacagcctg tacaactaca agatcgttgg 91740
atggcaaagt ttgatttcag cgcctttttt cccacgatat actgcgctat gttccccatg 91800
cattttagat taggcaaaat cgtcctggct agaatgcgtc gaggaatggg gtgcctaaaa 91860
cccgcgttgg tgtctttttt tggggggtta cggcacatac tcccgagtat atacaaagct 91920
attattttta tagccaatga aattagcctt tgcgtcgaac aaacggcctt ggaacagggc 91980
tttgctatat gtacttatat aaaagatgga ttttggggaa tcttcaccga tttacatacg 92040
cgcaatgtat gttcagatca ggcacgttgt tcggccttaa atttagcggc cacctgcgaa 92100
agagcagtca cgggcttatt acgaattcaa ctaggtctta actttacacc cgccatggaa 92160
ccggtactcc gggtcgaggg tgtgtacact cacgcattta cctggtgtac cacgggaagc 92220
tggctgtgga atttacaaac aaacacgcct ccggatttag ttggcgtgcc atggcgaagt 92280
caggcggcgc gagatttaaa ggagcgtctt tcaggactcc tatgtaccgc aacaaaaatt 92340
cgagaacgga tacaggaaaa ttgcatatgg gaccatgtcc tatacgacat atgggccgga 92400
caagttgtgg aggctgccag aaaaacatac gtcgattttt ttgaacatgt ttttgatcgc 92460
cgttatactc cggtatactg gagtcttcag gagcaaaatt cggaaacaaa agcaataccg 92520
gcatcttatc tgacatacgg acacatgcaa gataaggatt ataaaccaag acagataatt 92580
atggttcgta atcccaaccc acatggacct cctactgttg tttactggga attgctacca 92640
tcgtgtgcct gtattccccc catagactgc gctgctcatc tcaagcccct tatacacacg 92700
tttgtcacta ttattaacca tcttctagat gctcataatg atttttcaag tccatcattg 92760
aaatttactg acgatcccct tgcttcatat aacttcttgt ttttatgaca aaaaaacacg 92820
ccgcaacaac ccatccttaa aataaaaggt ttatttactt tacaacccgt ggtgaatttt 92880
tatacgtttc aaataactga acatttttcg gtgttaccat ggtgcgattt aaccaccaaa 92940
aatatacgct cttctgatat tccgaatctc gtaaaggtcc atttaacaat cccgggggta 93000
cttgcaccac accatctgga cagggggggg ttccgtgggg caggtcaaaa cgctgaccca 93060
ccccacatga atatatagcc tttataatat tgggggccgt tccaggctga gggttcagta 93120
acttaacaaa catataatgc ggcaatacgc gggtttttgt aaaggggttg ttatcaacga 93180
catacattag agtgtttaac aaccataaaa ctccctcata taaaaaccga cgcatttttt 93240
ccaaaggtcc tatttgacac tcaacgcgtc taagatatac agacaattgt acaaacagcg 93300
atggagatgc cccggagggc ccaatgcctt ccagatacat taaaataaca cataaggtaa 93360
aatctaggac attatccggg cggaatagag tcatccgata gattaacagg cgcggaggca 93420
cccccaccgt atacacccta tcttcaaccg cagttaatac ggaaaaaata aatccgcgga 93480
acgctggttg agtaacacac tccatgtagt aacgatcaca ggacacctca cttgaatcac 93540
cattcaacac tactaaaacg gtctcttggt gttccggttt tacgcgcagt gatacaacag 93600
agtttgccaa aaagcgtggc ttcaaaccgg ttacctcccg cgcctcgcat acgaatcttg 93660
gtattgcttg tattctaaga tcttcgatca cgtcgctcac atccaacccc tcttcggctc 93720
gtgttagtaa gttgtcgatc gttacgctgc aacctaaaat gctgggtata tttattccgg 93780
acatcccatc ggccatcccc gcgcctccgg tttgctcgaa ttttatccag taaggtcgaa 93840
tccgctgcat ttaccttgtg tacccgtaac ctctcagggg ggtgtccttt cataaaatgg 93900
gataggtttt tatatccaac atgcatgtat tggttattta ttttattggg ttccgggatt 93960
ctttcgtcat cttctgtagg gtcaggcaaa ccccaggaag gacttggtgt tctccgtggg 94020
ccccgtttta ttacctctgc gcgaacctgc atttcatata atattcggat ttgggataaa 94080
taggactctg ttctcgcctt tttaaaaata gcctggcata actcttcctc tgacctatgt 94140
acctcgcttt gagttaccaa gaatcctaat cgggtggccc gtaatatgaa tgaaaaatac 94200
ggcgcaacta gtaatgagat tgacgcattt gaatatgata cagaaatttc ctggccttga 94260
ttattgttta cccggtgaag cttaaaacag cgaacaagtt cctgtttcca tagctcagac 94320
aaacgtttta tatcatctcc ataagggggg atataacgag attgaaaact attggcaata 94380
tatgcatcat cccctattat gccggtaaga tctataacct cgtgatttaa atcggcaata 94440
cgtgtttctt ctgccattgt aatatgtgac cctttagatg gctttatttt taccctctct 94500
tcccgtaacc gtttcagctc tccttctttg aactggagcc tttcggtcag atcgctgttc 94560
acatccttga gaccctcaat ggttttgaat aaattattca cataaccctc gagcatgccg 94620
ttgatactgt taaccaccga agttttaaac gcactttgaa cgtttgttgt tccggacatt 94680
gcccccccgt taaaggattg gttggccttg ccaaaccccg gttgtgatgt gtccaccgat 94740
ccacttcctt ccagaatgtg attgcccgtt tcttctagat aggaacgtac ggtttcggta 94800
atatctccaa catgtctcat gttttttaag ttaactatta gctttacaag tctagacgcg 94860
gccgatccag cccgtgttgt atcgttctcg cccattatac gatcaaccgc acgtgtgctg 94920
tgagatctat catcttcatt ccggcgacct attaacacgc gcaaaggggc tgtatttaaa 94980
acttggcaga cgcgagcatg ttcacgtaat gcataacagg ccaacacctc cccagaaagc 95040
cgctgtaagg gtgagtcaaa tactacaccc tccccacata caacgggcgg ccacacgacc 95100
aaacactctc ccttcatgcc cgttacatca tcctttgcca taattaatct tcggttataa 95160
ttataataaa gacgcgtcct atcataatcc ataatagcaa cattttgcat acactcaact 95220
aggcttgtga caaccgccgc tcctctggcc aacgttgcat cggcaacttt taacatctgg 95280
gacagttctg ccgcttgacc catatacgta tttaatggtg caggggttcc attctgttct 95340
gatcgtacct ttcttacaac gggcacaata cctacacagg ctatccagtc cacgtatttg 95400
gcaaaaccga cccttccatt taaaccactg gtatagagac aaccggttat tccacgcaga 95460
aactcaagta acgatgactg taatgtttga cgccaggttt caaaaacctg atgtgcaagc 95520
cgtacggctt ctgattctcc acatagccca taacgttccg ctagagcccc ggcatgcagg 95580
ttacattgtt ggatgtggtg ttcccaatct gctgctaggt cctcataccg agttgcatcc 95640
aacgcgttca tcaaaacggt tgcctgaact tggcgaatta cagtttccgt agaccgtaca 95700
gcgctatata tgccttgtcc atcggtatat ccaaagtcac cggctaggat ttttcgaaac 95760
aacatacttt gcgtggttgg gtgtattaac atccagccat cttcctccgg aaatgtacaa 95820
aaccctatat ccggggcgta ctcattccag tatatatcga acatgttctt gtattggtca 95880
tttgggttac ttccattcaa gccctggtca atagaaacag aacttgctat ccttttttct 95940
tcactaccgg aactgttatt aaaaagagac gttatttcgg ccattgaaaa ccacgatgaa 96000
aagatcaatt tctgtagaca gttcttcacc caaaaacgtt tttaatccag agacgcccaa 96060
tggatttgat gacagtgtat atttaaactt cacctctatg catagcattc aacctatcct 96120
ctcacggatt cgagaacttg ccgcaattac gattccaaaa gaacgtgttc cgcggttgtg 96180
ttggtttaaa cagttactcg aactgcaagc gcctcctgaa atgcagagga atgagctccc 96240
cttctccgtt tatttaatta gcggaaatgc cggctccgga aaaagcacgt gtatccaaac 96300
gcttaacgaa gctatcgatt gcattattac cggatccacc agggttgctg cccaaaatgt 96360
tcatgctaag ttatcaacgg cttatgcgag tcgtccgata aacacaatct ttcatgaatt 96420
tggttttcgc ggaaatcaca ttcaggctca gctgggccgt tacgcatata actggactac 96480
gaccccccct tctattgagg acctgcaaaa aagagatatt gtatactact gggaagtttt 96540
aattgatata acaaaacgag tgtttcaaat gggggacgac ggtcgcggag gaacatcgac 96600
atttaaaacc ctgtgggcaa ttgaacgttt gcttaataaa cctacaggct caatgtccgg 96660
aaccgcgttt atcgcatgcg gttcccttcc ggcttttacc cggagcaacg ttattgttat 96720
tgatgaagca ggattgctag ggcgtcatat tctcacggcc gttgtttact gttggtggct 96780
tttgaatgct atatatcaaa gccctcagta cataaacggt cgaaaaccgg tcatagtatg 96840
cgtcggttcg cccacccaaa ctgactcgtt agaatctcat tttcaacatg acatgcagcg 96900
ttcacacgta actcctagtg aaaatatact cacgtatata atctgcaatc aaactctgcg 96960
tcaatatact aacatctcac ataactgggc aatctttatt aataacaaac gatgtcaaga 97020
ggacgatttt ggaaatcttt taaaaacgct tgagtacggg ctacctatta ccgaagcaca 97080
tgcgcgtctg gtcgatacat ttgttgtacc tgcatcctat attaacaatc ctgctaatct 97140
tcccggatgg acgcgtctgt attcgtcgca taaggaggtg agcgcgtata tgagtaagtt 97200
acacgcgcat ttaaaactat cgaaaaatga ccatttttct gtgtttgcct taccgactta 97260
tacattcatc cggctaacgg catttgatga ataccgcaaa ttaacgggac aacccggact 97320
ttctgttgaa cattggatac gggcaaactc cggtcgtttg cacaattatt cccaaagccg 97380
agatcatgac atgggaacag ttaaatacga aacacattca aatcgcgact taattgtagc 97440
ccgtacagac atcacttacg tgctaaatag tctcgtagtt gtaaccacaa gactacgtaa 97500
gttagttatt ggattcagtg gtacatttca atcgtttgca aaggttttac gtgacgactc 97560
ctttgtgaag gctcgaggag agacatccat cgaatatgct taccggtttc tgtcaaacct 97620
aatctttgga ggcttgatta acttttacaa ttttttgtta aataaaaacc tacatcccga 97680
taaggtatcg ttagcataca aacggttagc tgccttaacc ctggagttat tgtctggaac 97740
aaacaaagcc cccttacacg aagcagcggt taatggggcg ggtgccggga ttgactgtga 97800
tggtgcagct acttctgccg ataaagcctt ctgctttacc aaagcccccg agtccaaagt 97860
aacggcctcc atacccgaag acccggatga tgtaattttt acggcactta acgacgaggt 97920
tattgacttg gtatactgcc agtacgaatt ttcctatccc aaatcatcca atgaggtcca 97980
tgctcagttt ctgttaatga aagctattta cgatggtcga tatgccatat tagcagagct 98040
tttcgaaagc agctttacaa ccgccccctt tagcgcgtat gtcgataatg ttaatttcaa 98100
cggaagcgag cttttgatcg gcaatgtgcg gggggggctg ttatctttgg cattacaaac 98160
agatacgtat acccttttgg ggtatacttt tgcacccgtg ccagtctttg tagaggaact 98220
gacccgaaaa aagctgtacc gcgaaactac cgaaatgtta tatgctctac acgtacctct 98280
tatggtctta caggatcaac atgggtttgt gtccatcgta aacgctaacg tatgtgaatt 98340
taccgagtct atagaggatg cagaattggc aatggccacc acggtggact atggccttag 98400
ttctaaacta gccatgacaa ttgcacgctc acagggtctg agtttagaga aggtagctat 98460
ctgttttacg gcggataaac tgcgcctaaa tagtgtgtat gttgccatgt cgcgtacggt 98520
ctcctctagg ttcttaaaaa tgaatctaaa ccctctacgg gaacgatatg aaaaatccgc 98580
agaaattagc gatcacattc ttgccgctct acgtgatccc aacgtacacg ttgtgtatta 98640
aagcattgta taaaaacacg catgcgggct tgctgttctc atttctaggt tttgtcttaa 98700
atacacccgc catgagcatc tctggacccc caacgacgtt tattttatat aggttacatg 98760
gggttaggcg ggttcttcac tggactttac cggatcatga acaaacactc tacgcattta 98820
cgggtgggtc aagatcaatg gcggtgaaga cggacgctcg atgtgataca atgagcggtg 98880
gtatgatcgt ccttcaacac acccatacag tgaccctgct aaccatagac tgttctactg 98940
acttttcatc atacgcattt acgcaccggg atttccactt acaggacaaa ccccacgcaa 99000
catttgcgat gccgtttatg tcctgggtcg gttctgaccc aacatctcag ctgtacagta 99060
atgtgggggg ggtactatcc gtaataacgg aagatgacct atccatgtgt atctcaattg 99120
ttatatacgg tttacgggta aacagacctg acgatcagac cacaccaaca ccaaccccgc 99180
accagtatac atcgcaaagg cggcagcctg aaaccaactg tccttcttca ccacaaccgg 99240
cctttttcac atcagacgac gacgttcttt cgttaatatt acgggacgcc gcaaacgcgt 99300
aaagacagat tcaagactaa catttatccc aactgattac atttcatacg cgaataaacg 99360
acacaaaaaa tttatattta acggctttta atttgaagac acctatcctc ttaacgttga 99420
tgagccttgc aggttgggtg ccgcgcttca ccggtattat acataaccga tttaccgtgt 99480
ttacggcagt ctgaccattt accagtgtat gtctgtaata cgacgttgtt gtgtcccgac 99540
aaaattaact cgcgtacaaa tttctgatgt tcccccggcg tggcaacgct ggcatttcca 99600
aacacattac gttctcgtac gtccatgacc gctattttca gtattaattg gttggtcggt 99660
caaagtattt tccttatgta aaaggacacg atctaaagcc gtaaactcat acacaaacac 99720
tggtaccaac ggacgcgatt ttccgtccgt tgagcgggtg taatatcggc gaggtcttct 99780
tgcacgaata ctctcgtaca gtaggtttct gacacggggt gcatgggttt tttgacacaa 99840
cacaaacatt tgcaggctct tatgactgga tggattgaat ttatttttag atagggtcac 99900
gtgtttttgt cgtgacacgc ctcgaccaga aaaggctgcg gttttcgtac acgcgaccgt 99960
tatttcacag gcgttcataa ccaagctgcg gcggatggtg tcggttaatt gtctccgccc 100020
aagttcgtca atagatgata ccatgaacaa cgtatcaaat ggtacatagt cgtctttggt 100080
tttctcaata cagcccgcgt gcccaatcgg aaatttttca tttgcatcaa cgctattttc 100140
tgtaaaatcg ttctgaacac tgtgttggct ggctacctgt ttaaaatttg ggatcgaaca 100200
cggtccacga tgcaatcccc aaccccattg aagcaatgcc gtcggtacgg aaggaggcaa 100260
ctccgaaaac attatggtac gcaagagggt cgattggagt gttatataac actccaatcg 100320
atctcgggtt cgcctttacg cgtaaaatac tcattggctt gaacgaaatg tcgacaattc 100380
cgaaatggaa cacgggacaa tggcgacgga tgcgcgtgtg ttagcaccag atgacatctt 100440
gaattcggtt gggttgtctt ctgtgcatgc gcaccccaca gcataaaaac taaccctgta 100500
cggttctcgc ataacctctg tagcacgcgt tgcaccagcc gcccccagcc taagtataca 100560
tgcgaccccg gagtcccgcg acgaaccgta agcgtggtat tcagcaataa caccccctgc 100620
cttgcccaac tctccaggca tccgtgagtg ggcggagtca tatttgggta tgattccatg 100680
agggccgcaa aaatattttt aagactagac ggtggtgtta tgccacgttt tacactaaac 100740
gctagcccat gtgcatgtcc cgcggtaggg tatggatctt gaccaataat tacaacgcga 100800
atgctctggg gtccgcaaaa tcgcgtccat gcaaaaatat cgcctgtaga tggaagtatt 100860
tcttcccctg aatttaaaag acgattgtat tctaaaaaaa tacctttcgc gtacggctct 100920
ttaagttcgt ccgacaacag gtcataccac tcaggggaaa tgttaaactt gctgaaaact 100980
tcaaccgaat ccagttgcga agagacgggg gtgaacgttt ccgtgtcgta atgatgtgac 101040
atgttattta acttgaaggt tggggggtct agcttaaccc ccaaaggcag cccgcggggt 101100
cgcttgcggg tttttttggt aaccggatgg gccaaaacat aaatgtcctt tgaatccgat 101160
agtttcattt cattggcata cgcgttggaa caaacggtcg gctccccaga cacatccatt 101220
ttccgggata tttgtggaag atggagtaga gtctacccat acaccggaaa gggcatccaa 101280
caaagcatcg cgtatgtccc cgcttttatg ttcttcacca acagattgtg ccagcccctt 101340
taaggtgacg tatggatttg tccagtacgc catttgtttg tctttaaacc aaagtataac 101400
ttccggtact ggacattttg tcttaaccac gattcccgat agcgcctcgc tgaggtttga 101460
taccgggggt gccgcatagt cccacgcctc atataccgat gacacgcacg gttccgttat 101520
aatcaaactc acatccgata gcggtttggc tccaaaaaac aacggagtgt cgtcttggag 101580
atgaagacaa tacgcgattg tgatagtttt taaaaaaact atctgcagta accatttatg 101640
tgatgccatg acgcttgtgt tttcccttca ctacgacgtt gtcgtatcct ttgaaaaact 101700
tgaccactct aatggaagca tggacaagta tgagttttat atatacagtt ggcctttagt 101760
taaactcttg gtgtcatatc tcattttcct aaaaagggcg atcttaatat gtcaaacgtc 101820
acggcgtgcc gacaaagcga atttccatgc aagatttgga tgtagtattt atacacccaa 101880
tcacatgtca cgtattaagc tttacagtcc cccgttatct gatataatca cttttcttaa 101940
cacgtcatcg ggaaaacaga tgtttatatt atacctctcg cggtcattta cggcaaatac 102000
ttagaccgtt ttcaagcgga ctgaaaacgc tcaaattgcc ttttggaggc ctgcccaacg 102060
gccattatcc cttggatcta agattgattt gcggtaacgt ttgccaatca agctttaaaa 102120
acgtacccca aacttaaaac gctcaaattg ccttttggag gcctgcccaa cggccattat 102180
cccttggatc tgagattgat ttacggtaac gtttgccaaa cccacgcatt tcagtttaaa 102240
tatttctaag cattcttagt gcgtacttgg cagcgtgctt aaaatatcaa ccaatatcca 102300
ttatgctaca cgtttccttc tatccgtttc aatccattaa aagtccatta acaaaaatga 102360
tgcatcatac ctaattcacc taaaaacctg actcattgca gcagcgtttc ctccttgcag 102420
actatccagt tggcatttta aacgggtccg gctgcctaaa ccgaaaacac cgttgccttt 102480
actgtaagta caaaactaaa atttatattt gcgtgcgtat tttgtaacat atatgccttt 102540
tatccccccg caagtttgct ttaccctcgc cttcaccacc cccgccacct tccggccatt 102600
ttaataactt taattgctat aagacatacc caaaccggat gatttttgcc gctggaaaaa 102660
cagcttctaa ttttcccgtc tcaactcggc cttggttgca tctccaagta tacctttagt 102720
ttgctcccgt agaggtgtat aaatacaaac ggtgacaagt attgagcgta atctcaaatt 102780
tttgtaattt agggcggagc gcttacgaca gcacatgcgt actgttagac tgttatgttt 102840
attgtatttg cagagcagga tgccccggtt actccgagac cggattgcgg gcattccgaa 102900
tcgtgtacgg acttaccagg gggcagtatt tacaccttgg gttccagata taccaaccct 102960
tacgaccaat agcaacactc aggtattttt aaaatgcacg tttaatgatc ataatttaca 103020
tacagttggt aataaagcag actgtggatg tttaaggcat ttccttcccc ctcccaacaa 103080
actaggactt cttcatcttg tttggaatac ctttacccgc tttaccggca gagctttttt 103140
tggtaaggtg tttcagtgaa cctgatgttg atccggaggt ggagggggta ttggactccc 103200
cctgtggaga ggcaactttg cgggttttac ttcccttaca tgccgaatca gactcagatg 103260
tcaggtctat tgttaagcat cgtttaacgt ctctgccggt atgaaataaa cggcgcttag 103320
caccccttgc gcttcccggt ttaatccccg gtaacacaga aaaaagcctg actttttggg 103380
gtgtatttac caatcgggta tccctttcat cgccacgaga ggtctccccg gttgaggtgg 103440
tttctggtct tacaattgga cctgtaatta gttggatggc tgtatctttc caggtccagg 103500
tttgcatggt taggcgggtt ggatcggtac atcgatccaa caagaataac atgtttgtta 103560
caaacggtcc tgttgaatca tgcaaaagac aacgcaggga tgtttttaat cccgcctcat 103620
cacgcccgta aatacctata tagtttaata tcaacatttt tgtaggctct acaatttcgg 103680
gttgatacag ttccgcaagt tgatcatcaa gccatccgag taaaggttgc atgtaacacg 103740
ggaatctcgc gtttccctct gttcctctat ccgtggctcg aaaaggcagt ctgtccatgg 103800
ttcgtgggtc ttgattaatt cccacagata ctggacgatc acggtagtcc tgccccccgg 103860
tccggggttg ctgtgcagat tcaatcgagc catacaccac cggggtcgcc gatcgaacag 103920
caggttggtc tttaaaaaat accttccgta aaaatgatgc ggtagagcat gttttggtta 103980
caccagggct cgagtctcgg gtcggtggtt gtatagaatc ctgttgagag tcacttggtg 104040
actctgctgt gggctctcta gccgacgatt gaaggggccc agggtttggt gattgaatgg 104100
gctcccgact cgatcttgat gttggctgtt ggatggactc ccgactcggt cctgggcttg 104160
gtggcagaag atctatgaca tctcccggta ggatgtcgat ggaatcttca aatgacggct 104220
cagaaaaacc atcgtcgtcg gatgggtgca cttcatattc cttgtaactt gtatcactta 104280
cgatcttatg caggatggat tgcactggac accggcagag aggacactgg acgctggtgg 104340
aggtccatgc ccgaatacaa acaaagcaga agtcgtgcaa acacggcatg gtttttccga 104400
gatcggaaac ggtgctcatg catatggtgc aggtattatc cgaagcgtcg gaggtgccgc 104460
taccgcccgc taatatggta tccatggtaa caactggctg tattctaatg tccgggcatc 104520
caaacacgta gcagaactgc catgcgttct aaattgtgag ttgtggcgag tacattttta 104580
taattggtac caacgaagac acacccctat atccctccac ccatttcttt taagtcccac 104640
ccactaaaac gtgggtataa aatgtgtatt ggggtaggcg gacagtccca acaaacaggg 104700
aagttgattg gtataacctt gggccgggta tacagctaag tgacatttta gattctgtct 104760
ttatttagat aaagagcgat acgaagacat ttctccaccc ccctgtaata cccgtaaata 104820
aaggtaagtc cacaaacaaa agcactgtat ataggaagtc gggtgtattg ggacagttac 104880
tccattagag gcgtacaaac aatactggga tagggtaatg caagtccccc ccgatggtcg 104940
ccccgcaaac gcgcggggag gtggggtcgc tttttttttt ctctctcgag ggggccgcga 105000
gagggctggc ctcctctccc ggggtccgcc gggcgcccag aaaccggggg ggggttattt 105060
tcgggggggg gtccgaccag cccgcccgtc gcccgcccgc acagacagac agacactttt 105120
ttcataaaaa ccgttccgct tttattaaca acaaacagtc cgcgcgccag tggcgctcac 105180
gagaaaagga ggggactccg tcacccccga ctctgcgggg ggctcctccc cccgcgccct 105240
ccccacacat cgtcctcgtc ctcggaggac gaggacgagg acaacagctc caccttgacc 105300
gccgggcgca aacccacccg gcggtctcgc agcacacccg gggccaccga cacgatgctc 105360
accccaaagg atgaccccgg tgcgtccccg tcgtccccgc ccccctcctc gctgtcccac 105420
gcgtcttcac accccacctc ccaatcgtcc agctccaaag cgtgttctct gtcgtctgcg 105480
gtgcgccgct gtcgccccgc ctgggtttct gacggccgtt ccgagccccc gtggtgtccg 105540
aacacgaacc gtgttccgtc gctcccctcc aacaccgtct ccgcggcccc aaaaccgggc 105600
ggccacatta ctctgggaat cggggggagg gcattccgag cctcgtccgc cgacgcatac 105660
agcgccaccg accgaccggc cacgggtgga agcacgagtg gttctgcggc agggtcgggt 105720
tccagcaggg cgtggcggca aaacaccctc gcccaggtgg gtacgtcgcc ggcctccggc 105780
ccggcggccc ccggtctccg tccctcggga aggaagacgg gtcgaagcgc ggcacccagg 105840
ccccatcggt ttgctgcgcg gtggctatgt gccgcctcgt ccacaaagtc ggctgccccg 105900
agccccagac cccgagactg tcgcgcgagg tccttgcaac cgtcaaaacc cggcagcacg 105960
tactgccggt attcacgggg cgacaggggg acgcgggtct tggggcccgc gcgggtacac 106020
acggtgtatg cgacgttccc accgcggcac aaacacaggg gttgttcgcc cgggtacagg 106080
ttggcaaacg cagtctcgat acgagcaaaa ctcgctggcc caaaggtgcg cgacgatgca 106140
aacacggccc gggcgagtcc ttctgtgacc gccgagtctg gccatcggac gacggcctgg 106200
gcgtccggtc gcgccggggc ccggacgtac acgtgatact gagacaaagc gggtccatcc 106260
ctgggccacc tctcgagggc caccgcgtcc aacaccagca accggcgccg ggcagaggcc 106320
aaccgcgagc ctagatactc gacggccccg gcaaaggcca ggtctcgggt cgacagtaat 106380
aaaacgcccc gggcgttcaa agcggacacg tccggcgggc cggtccagtt cccggcccag 106440
gcatgagtgc tcggcaggca caaccggtta ctcagggctg ccaggaccac agacagtccc 106500
cctcgggatg gactccatga cggtcccgga tctgtcgcga gggtgctctc gagggggccg 106560
ttgatgtcct ctccgggcaa cggatcgtag atgatcagaa gcctcacatc ctccgggtct 106620
gggatctgcc gcatccaggc gcacctccgt cgcagcgcct ccactccgct gggtggacca 106680
aaccgtcggt ctcctccgcc cggacgccga gcggcgattt ccgccaaggc gccgggatca 106740
aagcttagcg cagggcgcca ggccgtggga aacaatgggt cgtcgaccag acgggcgatg 106800
gtttcggggg tacagtacgc cttgcgagcc tggtccgacg ggaccggggt atgcagggcc 106860
ccccggggaa tacgccgaaa tcccccgttt ggggccggtc cgtcaagtgg catcgttatt 106920
acggcggggg gatccaccac agggcccgag gtgatggtca cgggctcgga tacccgcctc 106980
ttggccttgg aaaccacatg atcgtctgca acccgggcgt ccgcgacggg tgtctcccta 107040
atcttgtcga ggaggcttct gctctcgact ggctgggact tgcgcttgcg cggagttcgt 107100
aaacgatcat ccggtggaca cacagaaaga gagcgtgcgg cggccgacgg ctgagggtcg 107160
ggagcctgtg tggccggggt tgttggagaa gggtgaccgc gggagatccg cgccgccgga 107220
ctggagcccg ttgcctcggg gtatgccatg ctggcaaagg ctctgcggag actctgtagg 107280
ataaagtgtt tttgggcccg gtcgtatcga cggctcatag ccacggccgc ggccgcgtgg 107340
gggagagccc agagggcctc ccccgtggcc atggcttcgc ctacatgcgg aacgggagac 107400
gctacgctcc ccgtaacggc ggtacccgcc cgtcccggtg gcaacagctt ttggtagaac 107460
tggttcaggg ccgagttgac accggtcagc ttggggttct ggagccatgc tatagggtct 107520
ctgtctggac agtagatcag gttaatcagc gcgcggtact gtctagccgg atctcccaac 107580
tccggcacgt aaagcggcac gggttccgtt gaggcctcgt aacgagcccg cgccgctctc 107640
acagcctcat cctcccagtg accctctctg gtctccccgg acggtccaaa ccgcaccctg 107700
ttggatggga ggggtgccga tccgggccaa gggcttccgt cgggcatcat gagcggcccc 107760
gacaccgggg gaattatcgg ggttctggat cgcggcaggg aaaatgattt ctgtctctgg 107820
cgccccggtt cccccgcaag acgtttggtc ttacgaatcc tcggatcggg accgctgatg 107880
gatcgatatc ccggttggat attttgtttc gtcgacccac catcatttga gtccgaatca 107940
tccgaatttg acggggaagg ggcgtgttcg cgtccggacc tgctgcctgt agtttcactt 108000
cccaccgaaa cgcgccgggg ttcatcgtct tcatcctccg atgacgatcc ccacgacgag 108060
gaagaggatg aagacgaaac aaactcacga ctctttggct ttttctccac tgggctgtca 108120
tcctcaatcg ggtctggtgc gtgggatctt cccggcaggg ccaaaaacgc tctaggtttg 108180
ccccccgacg aacgtccagg gacgcgaggt gttatacccc gggcatcatg tttccttggg 108240
cgggtatcat cggtctcaaa cggcaggtcc gcctttgccc ccttagcggg aacgctgtcc 108300
gaaaggacgt ggtacaattg ctcaaccggg ccgggtacag gtccaccggg tttccgcgcc 108360
gggagtggga ccttaacctt caaagtcttt ttcttcgggc tctttccctg agcgggccgt 108420
tgagttttct ggagaactac tccgtccccc gatgcatgcg catgacccgc ttgctcatcg 108480
cccggctttt tacccgagat ggactgagtt tgtctgtctc gatggaccac cgacggcaaa 108540
cctggtgaat ttcctctcgt cgtttgtcgg ggtatagacc gctggtcttc ccgttgatcg 108600
ttcccggcgg cgtctccaac aggagacgcg ggggatacag gggagaaggc ctgcgggaac 108660
ggaggggtcg tacctctgcc cgtttcccca tcgttcatcg gtggttttgg agacctagca 108720
agcttcgttc cgagagagac tgtctcaagg gagcgatcgg ctcctgttgg ttctcgcgcg 108780
ccggcctccg agaatcgggt gtggaagacc tcggccagcg ggattacagg cgagcccatt 108840
agatcctgac cgtcctcgca tacgtagtcg tcttgtgtta gctcttcgcc aacatcttcc 108900
gttctgggtt ctggttgaag tcccgatacg gagggaattg aaacgatctc gtgttcccgt 108960
cccaccatga ccccgttctc tccaaatagt agatcgtcag gctgactcga ggtgaccacc 109020
cgggccctgt gttcggcggc cgccgcggcc gcgtccaaca ggtccattaa ctccaaagta 109080
tcaggcgacc ccgcgcgttg gggtgtagag cgctgcatcg gcggcgtatc catcgcactg 109140
gggtgaattt agacgtaccc gagttttcca aacgctctcg cagccttcaa aggattgcga 109200
ttgcggttgg tgagggagtt ccaacagtac ttaaaacgtg ttgtgccccc ccctcgaccg 109260
catatttcct ccccgtgtcg tcaccgtgta aatattctta atgataagac gatgtagtga 109320
ttggacgaga ctcgaggcgg gaagttcatg gaccatagta tgcgtttaag gagagaccgc 109380
tggttggcga tgtacgcccg gtgtctattt ccgcatacct tacaacatca taacaaggga 109440
taccagacat gtgaatttca tttacatatg tttaaataac aaccaatcat cgtgtgtcta 109500
cagacgatat ataatataca taaacacaat tggggttgtc tcacatgcaa aacatcttat 109560
ataacacggg ttgtttccac ccatccggca tctagttaat caaatgcacg tcgacggtgt 109620
gtttgggtcc ctctccgtcg tcattacgtt cgcgcaatca acaagcgtat acaccaccac 109680
ccctcccaac gattatgtca ggcggcacga agcccgcgat aacccataaa atacacacgg 109740
ggttgtggtg ttcacgtaac cccccgccga tggggagggg gcgcggtacc ccgccgatgg 109800
ggagggggcg cggtaccccg ccgatgggga gggggcgcgg taccccgccg atggggaggg 109860
ggcgcggtac cccgccgatg gggagggggc gcggtacccc gccgatgttt ataaccataa 109920
ttctctaaac cgttgtagaa aatcacaaaa aaatttattc aaaaacaagt cgaagaactt 109980
catatctgag gcatgtaaac ccgttcgcac ttcctggggt ggaatggggt ggggtggggg 110040
ggtgaaaaag ggggggggtt aaattgggcg tccgcatgtc tgtggtgtac gccaatcgga 110100
tacactcttt tgatctgcat tcgcacttcc cgttttttca ctgtatgggt tttcatgttt 110160
tggcatgtgt ccaaccaccg ttcgcacttt ctttctatat atatatatat atatatatat 110220
atatatagag aaagagagag agtttcttgt tcgcgcgtgt tcccgcgatg tcgcggtttt 110280
atggggtgtg ggcgggcttt tcacagaata tatatattcc aaatggagcg gcaggctttt 110340
taaaatcgat ttgacgtgat aaaaaaaaac acacggggcc cccccctttt tttggtgtta 110400
taaaggcaac ccaatcgaag gtctcccgcc ccggaatccc ccattgccat tttacccaag 110460
tagccttatt catagatgta aacgtttggg tgtgtgtttt gttgtgcagg gttcgtccga 110520
ttcataacgc gacagcgtcg agtcggtttt aagggaaaag gttactacgg ccccaaggac 110580
atgttttgca cctcaccggc tacgcggggc gactcgtccg agtcaaaacc cggggcatcg 110640
gttgatgtta acggaaagat ggaatatgga tctgcaccag gacccctgaa cggccgggat 110700
acgtcgcggg gccccggcgc gttttgtact ccgggttggg agatccaccc ggccaggctc 110760
gttgaggaca tcaaccgtgt ttttttatgt attgcacagt cgtcgggacg cgtcacgcga 110820
gattcacgaa gattgcggcg catatgcctc gacttttatc taatgggtcg caccagacag 110880
cgtcccacgt tagcgtgctg ggaggaattg ttacagcttc aacccaccca gacgcagtgc 110940
ttacgcgcta ctttaatgga agtgtcccat cgaccccctc ggggggaaga cgggttcatt 111000
gaggcgccga atgttccttt gcataggagc gcactggaat gtgacgtatc tgatgatggt 111060
ggtgaagacg atagcgacga tgatgggtct acgccatcgg atgtaattga atttcgggat 111120
tccgacgcgg aatcatcgga cggggaagac tttatagtgg aagaagaatc agaggagagc 111180
accgattctt gtgaaccaga cggggtaccc ggcgattgtt atcgagacgg ggatgggtgc 111240
aacaccccgt ccccaaagag accccagcgt gccatcgagc gatacgcggg tgcagaaacc 111300
gcggaatata cagccgcgaa agcgctcacc gcgttgggcg aggggggtgt agattggaag 111360
cgacgtcgac acgaagcccc gcgccggcat gatataccgc ccccccatgg cgtgtagtct 111420
ttataaataa atacaatggt ttggctcgtg tctttttttg atgtctgtct gtgggggagt 111480
ggggtgttgt ggatattaga gggtagaggg tgctggtttg aacgtctcca ttaacccacg 111540
gggtccccac acgggccgtg tggtatgaat ctctgcggat cccgcggtga gcacccgggc 111600
ggtgaatatg ccggacttta ctgcacacga cacgataccc ccgcgcacca ggctctcatg 111660
aacgacgccg aacggtactt cgccgccgcg ctatgcgcca tatctaccga ggcctacgag 111720
gcttttatac acagcccctc cgagagaccg tgcgcgagtt tgtgggggag ggcaaaggac 111780
gccttcggac ggatgtgcgg ggagctcgca gcggatagac aacgtccacc ctcggttccg 111840
ccgatccgca gagcggtgtt atcgttatta cgcgagcaat gcatgccgga tccacaatcg 111900
catctggagc tcagcgagcg gctgatattg atggcatatt ggtgctgttt gggacacgcc 111960
ggacttccga ctattggatt gtcgcccgat aataaatgca tccgcgccga attatatgac 112020
cgccccgggg gaatttgtca caggcttttt gacgcgtacc tgggctgcgg gtcccttgga 112080
gtcccaagaa cctacgagag atcctgacac cccatccctt tatatagaaa aaaaaaataa 112140
atttaaaaca tacaccggat aaaagcgtac tgttttttat ttaaatttac acgctcggcg 112200
ttgccccggt tcggtgatca ccgggtctta tctatataca ccgtgtaact cgaacccccg 112260
tgactccctc caatcgcgtt accaaactct tcttccgtat ccgtagattc cgagtcctcg 112320
aaatcgtcca cttatccaac aaattgtgac gttatatatc ccaaggcaaa ggccgctccc 112380
gtcatagcaa atacaaagac aattattagc gtaatataac agaatttttt acgatgatat 112440
attttatgtt gatattttcc aattcgacgc aaaaattcat ctgccgtttc attttcgcta 112500
tcactataat aacacttttc agccgaacgg ctcggttgta tggctgttat cgttgtatta 112560
tttggttgcg ctcgcggggt taccaccgct tccatcagta aggccacggc ctcaccctcc 112620
atggtgtttt gtccggccat agaaatccag attgtaaggc cagcaggcta gtttaaaagt 112680
gtttaatacc acaccttttg atatttatat acatgcaaga ttctagatta ttcatcaata 112740
ggtcgtttaa agcgcgtttt cataaacgtt gtcagctata ccgacattct cacaaagagg 112800
taaagttacc ttacgttatt attaaataaa acatgtagac attattaata atcctaggaa 112860
caatcaaatc catatttgta agttatgttt aacccctccc ctttttgtca ttatctccgc 112920
cctcttataa tcggatcact ttataagtgt gtcggtgagt atattttgta cagttgttgg 112980
acaacaggtt tttggttcat taacactatc aacataagtc ggggtataca agtataatga 113040
acgacgttga tgcaacagac acctttgttg gacaaggaaa gttccgtggc gccatctcaa 113100
catcaccgtc acatattatg caaacatgtg ggtttataca acagatgttt ccagttgaaa 113160
tgtcgcccgg catagaatct gaggatgatc ccaattatga cgttaacatg gatatacagt 113220
cttttaatat atttgatggt gtacacgaaa ctgaagccga agcctctgtg gcattgtgcg 113280
cagaagcacg cgttggaatt aataaagcgg gatttgtaat attaaaaacg tttacaccag 113340
gggcggaagg ttttgcgttt gcgtgtatgg acagtaaaac atgtgaacat gtggtcatta 113400
aagcgggtca acgtcaagga acggccaccg aggcaaccgt gttaagagcg ttaacccacc 113460
catccgttgt acagcttaaa ggaacgttta cgtataacaa aatgacatgt cttatattac 113520
cacgttaccg aacagattta tactgctatc tagctgcaaa gcgcaacctc cccatatgtg 113580
acattttagc aattcagcga tctgtattac gcgcgttaca gtatcttcat aataacagta 113640
ttattcaccg tgatataaaa tctgaaaata tatttattaa ccacccaggt gatgtttgtg 113700
tgggagactt tggagcagcg tgtttccccg tggatattaa tgccaacagg tattatggct 113760
gggctggaac aatcgccaca aactctcctg agttattggc tagagatcca tatggacctg 113820
ccgtggacat atggagtgcc gggattgtat tatttgaaat ggctacagga cagaactcgt 113880
tatttgaacg agacggttta gatggcaatt gtgacagtga gcgtcaaatt aaacttatta 113940
tacgacgatc tggaactcat cccaatgaat ttcccattaa ccctacatca aatcttcgtc 114000
gacaatacat tggtttggca aaacggtctt ctcgaaaacc cggatccagg ccattgtgga 114060
caaatctata tgagttgcca attgatttgg agtatttgat atgtaagatg ttatcgtttg 114120
acgcacgtca tcgaccatca gcagaggtgt tgcttaacca ctctgttttc caaactcttc 114180
ccgatccata tccaaatcca atggaagttg gagattaaaa ttcattaagc ctgttaataa 114240
aatattgtat aaattgtgtt tataacgtat aacccgttaa ggcaaatagg gtacaaacgc 114300
gcaatgtttt gaaatactaa tataaataac ataaccaata gaaacttaat acagagtcac 114360
gccccattac aacaaggata aaacacggga tcattttctt aacattgtag tagcgctgaa 114420
aagcgtcccc tcccccggct cacagagctg ctcttcggtg tagttgggta tactggtgcg 114480
cctcatttaa tcgcgatgtt tttaatccaa tgtttgatat cggccgttat attttacata 114540
caagtgacca acgctttgat cttcaagggc gaccacgtga gcttgcaagt taacagcagt 114600
ctcacgtcta tccttattcc catgcaaaat gataattata cagagataaa aggacagctt 114660
gtctttattg gagagcaact acctaccggg acaaactata gcggaacact ggaactgtta 114720
tacgcggata cggtggcgtt ttgtttccgg tcagtacaag taataagata cgacggatgt 114780
ccccggatta gaacgagcgc ttttatttcg tgtaggtaca aacattcgtg gcattatggt 114840
aactcaacgg atcggatatc aacagagccg gatgctggtg taatgttgaa aattaccaaa 114900
ccgggaataa atgatgctgg tgtgtatgta cttcttgttc ggttagacca tagcagatcc 114960
accgatggtt tcattcttgg tgtaaatgta tatacagcgg gctcgcatca caacattcac 115020
ggggttatct acacttctcc gtctctacag aatggatatt ctacaagagc cctttttcaa 115080
caagctcgtt tgtgtgattt acccgcgaca cccaaagggt ccggtacctc cctgtttcaa 115140
catatgcttg atcttcgtgc cggtaaatcg ttagaggata acccttggtt acatgaggac 115200
gttgttacga cagaaactaa gtccgttgtt aaggagggga tagaaaatca cgtatatcca 115260
acggatatgt ccacgttacc cgaaaagtcc cttaatgatc ctccagaaaa tctacttata 115320
attattccta tagtagcgtc tgtcatgatc ctcaccgcca tggttattgt tattgtaata 115380
agcgttaagc gacgtagaat taaaaaacat ccaatttatc gcccaaatac aaaaacaaga 115440
aggggcatac aaaatgcgac accagaatcc gatgtgatgt tggaggccgc cattgcacaa 115500
ctagcaacga ttcgcgaaga atccccccca cattccgttg taaacccgtt tgttaaatag 115560
aactaattat cccggatttt atattaaata aactatatgc gttttattta gcgttttgat 115620
tacgcgttgt gatatgaggg gaaggattaa gaatctccta actataagtt aacacgccca 115680
catttgggcg gggatgtttt atgaagcctt aaaggccgag ctggtataca cgagagcagt 115740
ccatggtttt agacctcggg cgaattgcgt ggttttaagt gactatattc cgagggtcgc 115800
ctgtaatatg gggacagtta ataaacctgt ggtgggggta ttgatggggt tcggaattat 115860
cacgggaacg ttgcgtataa cgaatccggt cagagcatcc gtcttgcgat acgatgattt 115920
tcacaccgat gaagacaaac tggatacaaa ctccgtatat gagccttact accattcaga 115980
tcatgcggag tcttcatggg taaatcgggg agagtcttcg cgaaaagcgt acgatcataa 116040
ctcaccttat atatggccac gtaatgatta tgatggattt ttagagaacg cacacgaaca 116100
ccatggggtg tataatcagg gccgtggtat cgatagcggg gaacggttaa tgcaacccac 116160
acaaatgtct gcacaggagg atcttgggga cgatacgggc atccacgtta tccctacgtt 116220
aaacggcgat gacagacata aaattgtaaa tgtggaccaa cgtcaatacg gtgacgtgtt 116280
taaaggagat cttaatccaa aaccccaagg ccaaagactc attgaggtgt cagtggaaga 116340
aaatcacccg tttactttac gcgcaccgat tcagcggatt tatggagtcc ggtacaccga 116400
gacttggagc tttttgccgt cattaacctg tacgggagac gcagcgcccg ccatccagca 116460
tatatgttta aaacatacaa catgctttca agacgtggtg gtggatgtgg attgcgcgga 116520
aaatactaaa gaggatcagt tggccgaaat cagttaccgt tttcaaggta agaaggaagc 116580
ggaccaaccg tggattgttg taaacacgag cacactgttt gatgaactcg aattagaccc 116640
ccccgagatt gaaccgggtg tcttgaaagt acttcggaca gaaaaacaat acttgggtgt 116700
gtacatttgg aacatgcgcg gctccgatgg tacgtctacc tacgccacgt ttttggtcac 116760
ctggaaaggg gatgaaaaaa caagaaaccc tacgcccgca gtaactcctc aaccaagagg 116820
ggctgagttt catatgtgga attaccactc gcatgtattt tcagttggtg atacgtttag 116880
cttggcaatg catcttcagt ataagataca tgaagcgcca tttgatttgc tgttagagtg 116940
gttgtatgtc cccatcgatc ctacatgtca accaatgcgg ttatattcta cgtgtttgta 117000
tcatcccaac gcaccccaat gcctctctca tatgaattcc ggttgtacat ttacctcgcc 117060
acatttagcc cagcgtgttg caagcacagt gtatcaaaat tgtgaacatg cagataacta 117120
caccgcatat tgtctgggaa tatctcatat ggagcctagc tttggtctaa tcttacacga 117180
cgggggcacc acgttaaagt ttgtagatac acccgagagt ttgtcgggat tatacgtttt 117240
tgtggtgtat tttaacgggc atgttgaagc cgtagcatac actgttgtat ccacagtaga 117300
tcattttgta aacgcaattg aagagcgtgg atttccgcca acggccggtc agccaccggc 117360
gactactaaa cccaaggaaa ttacccccgt aaaccccgga acgtcaccac ttctacgata 117420
tgccgcatgg accggagggc ttgcagcagt agtactttta tgtctcgtaa tatttttaat 117480
ctgtacggct aaacgaatga gggttaaagc ctatagggta gacaagtccc cgtataacca 117540
aagcatgtat tacgctggcc ttccagtgga cgatttcgag gactcggaat ctacggatac 117600
ggaagaagag tttggtaacg cgattggagg gagtcacggg ggttcgagtt acacggtgta 117660
tatagataag acccggtgat caccgaaccg gggcaacgcc gagcgtgtaa atttaaataa 117720
aaaacagtac gcttttatcc ggtgtatgtt ttaaatttat tttttttttc tatataaagg 117780
gatggggtgt caggatctct cgtaggttct tgggactcca agggacccgc agcccaggta 117840
cgcgtcaaaa agcctgtgac aaattccccc ggggcggtca tataattcgg cgcggatgca 117900
tttattatcg ggcgacaatc caatagtcgg aagtccggcg tgtcccaaac agcaccaata 117960
tgccatcaat atcagccgct cgctgagctc cagatgcgat tgtggatccg gcatgcattg 118020
ctcgcgtaat aacgataaca ccgctctgcg gatcggcgga accgagggtg gacgttgtct 118080
atccgctgcg agctccccgc acatccgtcc gaaggcgtcc tttgccctcc cccacaaact 118140
cgcgcacggt ctctcggagg ggctgtgtat aaaagcctcg taggcctcgg tagatatggc 118200
gcatagcgcg gcggcgaagt accgttcggc gtcgttcatg agagcctggt gcgcgggggt 118260
atcgtgtcgt gtgcagtaaa gtccggcata ttcaccgccc gggtgctcac cgcgggatcc 118320
gcagagattc ataccacacg gcccgtgtgg ggaccccgtg ggttaatgga gacgttcaaa 118380
ccagcaccct ctaccctcta atatccacaa caccccactc ccccacagac agacatcaaa 118440
aaaagacacg agccaaacca ttgtatttat ttataaagac tacacgccat gggggggcgg 118500
tatatcatgc cggcgcgggg cttcgtgtcg acgtcgcttc caatctacac ccccctcgcc 118560
caacgcggtg agcgctttcg cggctgtata ttccgcggtt tctgcacccg cgtatcgctc 118620
gatggcacgc tggggtctct ttggggacgg ggtgttgcac ccatccccgt ctcgataaca 118680
atcgccgggt accccgtctg gttcacaaga atcggtgctc tcctctgatt cttcttccac 118740
tataaagtct tccccgtccg atgattccgc gtcggaatcc cgaaattcaa ttacatccga 118800
tggcgtagac ccatcatcgt cgctatcgtc ttcaccacca tcatcagata cgtcacattc 118860
cagtgcgctc ctatgcaaag gaacattcgg cgcctcaatg aacccgtctt ccccccgagg 118920
gggtcgatgg gacacttcca ttaaagtagc gcgtaagcac tgcgtctggg tgggttgaag 118980
ctgtaacaat tcctcccagc acgctaacgt gggacgctgt ctggtgcgac ccattagata 119040
aaagtcgagg catatgcgcc gcaatcttcg tgaatctcgc gtgacgcgtc ccgacgactg 119100
tgcaatacat aaaaaaacac ggttgatgtc ctcaacgagc ctggccgggt ggatctccca 119160
acccggagta caaaacgcgc cggggccccg cgacgtatcc cggccgttca ggggtcctgg 119220
tgcagatcca tattccatct ttccgttaac atcaaccgat gccccgggtt ttgactcgga 119280
cgagtcgccc cgcgtagccg gtgaggtgca aaacatgtcc ttggggccgt agtaaccttt 119340
tcccttaaaa ccgactcgac gctgtcgcgt tatgaatcgg acgaaccctg cacaacaaaa 119400
cacacaccca aacgtttaca tctatgaata aggctacttg ggtaaaatgg caatggggga 119460
ttccggggcg ggagaccttc gattgggttg cctttataac accaaaaaaa ggggggggcc 119520
ccgtgtgttt ttttttatca cgtcaaatcg attttaaaaa gcctgccgct ccatttggaa 119580
tatatatatt ctgtgaaaag cccgcccaca ccccataaaa ccgcgacatc gcgggaacac 119640
gcgcgaacaa gaaactctct ctctttctct atatatatat atatatatat atatatatat 119700
agaaagaaag tgcgaacggt ggttggacac atgccaaaac atgaaaaccc atacagtgaa 119760
aaaacgggaa gtgcgaatgc agatcaaaag agtgtatccg attggcgtac accacagaca 119820
tgcggacgcc caatttaacc cccccccttt ttcacccccc caccccaccc cattccaccc 119880
caggaagtgc gaacgggttt acatgcctca gatatgaagt tcttcgactt gtttttgaat 119940
aaattttttt gtgattttct acaacggttt agagaattat ggttataaac atcggcgggg 120000
taccgcgccc cctccccatc ggcggggtac cgcgccccct ccccatcggc ggggtaccgc 120060
gccccctccc catcggcggg gtaccgcgcc ccctccccat cggcggggta ccgcgccccc 120120
tccccatcgg cggggggtta cgtgaacacc acaaccccgt gtgtatttta tgggttatcg 120180
cgggcttcgt gccgcctgac ataatcgttg ggaggggtgg tggtgtatac gcttgttgat 120240
tgcgcgaacg taatgacgac ggagagggac ccaaacacac cgtcgacgtg catttgatta 120300
actagatgcc ggatgggtgg aaacaacccg tgttatataa gatgttttgc atgtgagaca 120360
accccaattg tgtttatgta tattatatat cgtctgtaga cacacgatga ttggttgtta 120420
tttaaacata tgtaaatgaa attcacatgt ctggtatccc ttgttatgat gttgtaaggt 120480
atgcggaaat agacaccggg cgtacatcgc caaccagcgg tctctcctta aacgcatact 120540
atggtccatg aacttcccgc ctcgagtctc gtccaatcac tacatcgtct tatcattaag 120600
aatatttaca cggtgacgac acggggagga aatatgcggt cgaggggggg gcacaacacg 120660
ttttaagtac tgttggaact ccctcaccaa ccgcaatcgc aatcctttga aggctgcgag 120720
agcgtttgga aaactcgggt acgtctaaat tcaccccagt gcgatggata cgccgccgat 120780
gcagcgctct acaccccaac gcgcggggtc gcctgatact ttggagttaa tggacctgtt 120840
ggacgcggcc gcggcggccg ccgaacacag ggcccgggtg gtcacctcga gtcagcctga 120900
cgatctacta tttggagaga acggggtcat ggtgggacgg gaacacgaga tcgtttcaat 120960
tccctccgta tcgggacttc aaccagaacc cagaacggaa gatgttggcg aagagctaac 121020
acaagacgac tacgtatgcg aggacggtca ggatctaatg ggctcgcctg taatcccgct 121080
ggccgaggtc ttccacaccc gattctcgga ggccggcgcg cgagaaccaa caggagccga 121140
tcgctccctt gagacagtct ctctcggaac gaagcttgct aggtctccaa aaccaccgat 121200
gaacgatggg gaaacgggca gaggtacgac ccctccgttc ccgcaggcct tctcccctgt 121260
atcccccgcg tctcctgttg gagacgccgc cgggaacgat caacgggaag accagcggtc 121320
tataccccga caaacgacga gaggaaattc accaggtttg ccgtcggtgg tccatcgaga 121380
cagacaaact cagtccatct cgggtaaaaa gccgggcgat gagcaagcgg gtcatgcgca 121440
tgcatcgggg gacggagtag ttctccagaa aactcaacgg cccgctcagg gaaagagccc 121500
gaagaaaaag actttgaagg ttaaggtccc actcccggcg cggaaacccg gtggacctgt 121560
acccggcccg gttgagcaat tgtaccacgt cctttcggac agcgttcccg ctaagggggc 121620
aaaggcggac ctgccgtttg agaccgatga tacccgccca aggaaacatg atgcccgggg 121680
tataacacct cgcgtccctg gacgttcgtc ggggggcaaa cctagagcgt ttttggccct 121740
gccgggaaga tcccacgcac cagacccgat tgaggatgac agcccagtgg agaaaaagcc 121800
aaagagtcgt gagtttgttt cgtcttcatc ctcttcctcg tcgtggggat cgtcatcgga 121860
ggatgaagac gatgaacccc ggcgcgtttc ggtgggaagt gaaactacag gcagcaggtc 121920
cggacgcgaa cacgcccctt ccccgtcaaa ttcggatgat tcggactcaa atgatggtgg 121980
gtcgacgaaa caaaatatcc aaccgggata tcgatccatc agcggtcccg atccgaggat 122040
tcgtaagacc aaacgtcttg cgggggaacc ggggcgccag agacagaaat cattttccct 122100
gccgcgatcc agaaccccga taattccccc ggtgtcgggg ccgctcatga tgcccgacgg 122160
aagcccttgg cccggatcgg cacccctccc atccaacagg gtgcggtttg gaccgtccgg 122220
ggagaccaga gagggtcact gggaggatga ggctgtgaga gcggcgcggg ctcgttacga 122280
ggcctcaacg gaacccgtgc cgctttacgt gccggagttg ggagatccgg ctagacagta 122340
ccgcgcgctg attaacctga tctactgtcc agacagagac cctatagcat ggctccagaa 122400
ccccaagctg accggtgtca actcggccct gaaccagttc taccaaaagc tgttgccacc 122460
gggacgggcg ggtaccgccg ttacggggag cgtagcgtct cccgttccgc atgtaggcga 122520
agccatggcc acgggggagg ccctctgggc tctcccccac gcggccgcgg ccgtggctat 122580
gagccgtcga tacgaccggg cccaaaaaca ctttatccta cagagtctcc gcagagcctt 122640
tgccagcatg gcataccccg aggcaacggg ctccagtccg gcggcgcgga tctcccgcgg 122700
tcacccttct ccaacaaccc cggccacaca ggctcccgac cctcagccgt cggccgccgc 122760
acgctctctt tctgtgtgtc caccggatga tcgtttacga actccgcgca agcgcaagtc 122820
ccagccagtc gagagcagaa gcctcctcga caagattagg gagacacccg tcgcggacgc 122880
ccgggttgca gacgatcatg tggtttccaa ggccaagagg cgggtatccg agcccgtgac 122940
catcacctcg ggccctgtgg tggatccccc cgccgtaata acgatgccac ttgacggacc 123000
ggccccaaac gggggatttc ggcgtattcc ccggggggcc ctgcataccc cggtcccgtc 123060
ggaccaggct cgcaaggcgt actgtacccc cgaaaccatc gcccgtctgg tcgacgaccc 123120
attgtttccc acggcctggc gccctgcgct aagctttgat cccggcgcct tggcggaaat 123180
cgccgctcgg cgtccgggcg gaggagaccg acggtttggt ccacccagcg gagtggaggc 123240
gctgcgacgg aggtgcgcct ggatgcggca gatcccagac ccggaggatg tgaggcttct 123300
gatcatctac gatccgttgc ccggagagga catcaacggc cccctcgaga gcaccctcgc 123360
gacagatccg ggaccgtcat ggagtccatc ccgaggggga ctgtctgtgg tcctggcagc 123420
cctgagtaac cggttgtgcc tgccgagcac tcatgcctgg gccgggaact ggaccggccc 123480
gccggacgtg tccgctttga acgcccgggg cgttttatta ctgtcgaccc gagacctggc 123540
ctttgccggg gccgtcgagt atctaggctc gcggttggcc tctgcccggc gccggttgct 123600
ggtgttggac gcggtggccc tcgagaggtg gcccagggat ggacccgctt tgtctcagta 123660
tcacgtgtac gtccgggccc cggcgcgacc ggacgcccag gccgtcgtcc gatggccaga 123720
ctcggcggtc acagaaggac tcgcccgggc cgtgtttgca tcgtcgcgca cctttgggcc 123780
agcgagtttt gctcgtatcg agactgcgtt tgccaacctg tacccgggcg aacaacccct 123840
gtgtttgtgc cgcggtggga acgtcgcata caccgtgtgt acccgcgcgg gccccaagac 123900
ccgcgtcccc ctgtcgcccc gtgaataccg gcagtacgtg ctgccgggtt ttgacggttg 123960
caaggacctc gcgcgacagt ctcggggtct ggggctcggg gcagccgact ttgtggacga 124020
ggcggcacat agccaccgcg cagcaaaccg atggggcctg ggtgccgcgc ttcgacccgt 124080
cttccttccc gagggacgga gaccgggggc cgccgggccg gaggccggcg acgtacccac 124140
ctgggcgagg gtgttttgcc gccacgccct gctggaaccc gaccctgccg cagaaccact 124200
cgtgcttcca cccgtggccg gtcggtcggt ggcgctgtat gcgtcggcgg acgaggctcg 124260
gaatgccctc cccccgattc ccagagtaat gtggccgccc ggttttgggg ccgcggagac 124320
ggtgttggag gggagcgacg gaacacggtt cgtgttcgga caccacgggg gctcggaacg 124380
gccgtcagaa acccaggcgg ggcgacagcg gcgcaccgca gacgacagag aacacgcttt 124440
ggagctggac gattgggagg tggggtgtga agacgcgtgg gacagcgagg aggggggcgg 124500
ggacgacggg gacgcaccgg ggtcatcctt tggggtgagc atcgtgtcgg tggccccggg 124560
tgtgctgcga gaccgccggg tgggtttgcg cccggcggtc aaggtggagc tgttgtcctc 124620
gtcctcgtcc tccgaggacg aggacgatgt gtggggaggg cgcgggggga ggagcccccc 124680
gcagagtcgg gggtgacgga gtcccctcct tttctcgtga gcgccactgg cgcgcggact 124740
gtttgttgtt aataaaagcg gaacggtttt tatgaaaaaa gtgtctgtct gtctgtgcgg 124800
gcgggcgacg ggcgggctgg tcggaccccc ccccgaaaat aacccccccc cggtttctgg 124860
gcgcccggcg gaccccggga gagg 124884
<210>2
<211>125157
<212>DNA
<213>减毒水痘病毒Oka株
<400>2
ggcccagccc tctcgcggcc ccctcgagag agaaaaaaaa aagcgacccc acctccccgc 60
gcgtttgcgg ggcgaccatc gggggggatg ggattttttg ccgggaaacc ccccccgcca 120
gcctttaaca aaacccgcgc cttttgcgtc cacccctcgt ttactgctcg gatggcgacc 180
gtgcactact cccgccgacc tgggaccccg ccggtcaccc tcacgtcgtc ccccggcatg 240
gatgacgttg cgacccccat tccctaccta cccacatacg ccgaggccgt ggcagacgcg 300
cccccccctt acagaagccg cgagagtctg gtgttctccc cgcctctttt tcctcacgtg 360
gagaatggca ccacccaaca gtcttacgat tgcctagact gcgcttatga tggaatccac 420
agacttcagc tggcttttct aagaattcgc aaatgctgtg taccggcttt tttaattctt 480
tttggtattc tcacccttac tgctgtcgtg gtcgccattg ttgccgtttt tcccgaggaa 540
cctcccaact caactacacg aaactactgt ccggaagggg aaggtattta ttctcgcttg 600
cagcttgtcg cgcgtgtatg cacaacaaaa gctatatatg tcaccaaagc caacgtcgcc 660
atctggagta ctacacccag tacattgcat aacctgtcca tytgcatttt cagttgcgcg 720
gacgcctttc tccgggatcg tggccttggg acatcaacca gyggaataag aaccgccggt 780
ggtcttgccc gaacgacgag tggcgacgcg ttgttctgca taagctctgt atgctgatac 840
ataaacacag agtctgtatc gctatcagat tcccgaacac cttccggtac cccatactcc 900
gataccctgg acattgcgga tcccaaaaat ataatattaa caggatttgc ttatactttg 960
ctacagctta tataaattta tgtgcgatac atcttaagtg catccgtacg ttatttatac 1020
attgcctgtc acgtgaaaag actgtgttac ccaataaagg ttctacaaaa aatgctttat 1080
tgggtgtttg tttaatagct attatcgtaa cccacccccg taaaatcata aaatgcatgt 1140
aatttctgag acacttgcat atgggcatgt tcccgcattt attatgggct ccactctggt 1200
gcgtcccagt ttaaacgcca ccgccgagga aaatcccgcg tcagaaacgc gatgtttatt 1260
acgagtgctt gcggggagaa ctgtagacct gccaggcgga ggaacgttac acattacctg 1320
taccaaaacc tatgtaatta ttggcaaata tagcaaaccc ggcgaacgtc ttagccttgc 1380
ccgtctaata gggcgtgcaa tgacgcctgg aggtgcaagg acatttatta ttttggcgat 1440
gaaggaaaag cgatccacaa cgcttgggta tgaatgtggt acgggcttgc atttactggc 1500
tccatctatg ggtacatttc tccgcacaca cggtttaagt aacagagatc tctgtttatg 1560
gcggggtaat atttatgata tgcatatgca acgtcttatg ttttgggaga atatcgcgca 1620
aaataccact gaaacacctt gtataacgtc gacgttaaca tgcaacttga cagaagactc 1680
tggtgaagcc gcacttacca cgtcagaccg acccactctc ccaaccctaa cagcccaagg 1740
aagaccaaca gtttccaaca ttcgtggaat attgaaagga tccccccgtc aacagccggt 1800
ctgtcaccgg gttagatttg ccgaacctac ggagggcgta ttgatgtaat cactaaataa 1860
aatacacctt ttttcgattg tacgtatttt tatttaaatg tgtagttcat agtccgccga 1920
cagccgctcg ggcttttccc ccacatacaa catgatcgta tgcctcggat gcaccggtcc 1980
aacactccgc cgagaagggg gatttacaat gacagtgata cccaatagcc gccagatgta 2040
cacccagctg tccggactcc agcatcatct gctgagttgc ggcgctgaag ggtgcatcgc 2100
atagggtgtt ataattagcc atttccggta acagtcgttg ggaatttagg aggctgcaaa 2160
acggctgtag gtcaacatac attggggatt cagatggttt atctcgacgt ccaagtccaa 2220
tcaaaaaagc gtgtaaatca tcagcccggc cgcatgttgc tcgaagagca cataacctct 2280
taacaccgta cagaggggat ggcgtcggtg catgtgagtt ggcagggcat gtccacgttg 2340
tttccaacgc cagtggcggt ataacttgtg taaacgacgc caacgggtca ggtttaagat 2400
tcactcggat gggttgactg ctttcggaag ctcccgttgt atccattaat taaacgttcg 2460
gtacacgtct ggtgtgtgtt ttacccgaat cagagacgga attgcaaaga tatyggtttg 2520
aaagcaatgt aatcccgccc atatatcccc aacgtcgcct taaaaactcc cacaatatta 2580
catttttatt agtcttttat taatatagaa tcacataaac aattgataaa atcaaggggt 2640
ggtgtataat gattaaaaat ataaattgat atgttttaca agcatgaaat aggtatttac 2700
tattctaaca ggtaaatatg cttaatgatt aaaaatacaa attagtatgt tttgacaagc 2760
atgaaaaagg tattttttat tttagcagtt aaaggtacta cacttaaaat atttaccgta 2820
tggacgggcg tcagaaagat gcccggccca agttgagagg gtacattcaa cacgaccaca 2880
ctcgcgttgg tgggtgatta gggcctctaa aacaccggcc agacatgacc cgggtgtata 2940
ttcttgtaac acttgaacgt tacaactgat atcatcatat tccacaaatt tagagccacg 3000
gacaactata ttagcaatgc gggcaatcat aacaaacata taagtagtaa tacacgtgat 3060
atcactaaaa cgttgctggc gcaacagttc ggggagagta cgagacccca aatcgttgtc 3120
cctgtttaga agaagacatc ttacaaaagg ccccagcttt aactttaaat tctccaaaag 3180
tgacttcgag gttgcaacaa tgggattatt tgtgtagatg ggcaagtttt ttgccgctaa 3240
cattttaatc cacgttaaca gttcatccgc agactccaac gcttcaatca aagattctcc 3300
acgtatgact ctctcacgca acgcgcgggc aatacgtgag tccattttat atgactcaaa 3360
ggtacgataa agttcatgtc cgtacaacat caactccggc caagatgtgt tttgttttat 3420
ccccggaaaa catccaccgg aagcccatga atcaccctct tgtattgtgg catatcggac 3480
taccagtttt tcaattgttt catctaaatg gcgtaccgag tcaatggtca cgctggctcc 3540
cgcggtggag acgacttcaa tagcacggcc cgtaattcga tcgaccggga tatcatactc 3600
ttttcgaata cgctctcggc gggcgtctct cttggaaaat cgcaacctgt acgattcgtc 3660
atgtgtctga tcatttcttt ctcccgtggt cattgcagga ggcgttgtag gacgccgtct 3720
tcgatttgac agggatcgat cacggtgttt tcttgaactt tgggtgttat aagatctgga 3780
tgatcgtcga tgtccccgtt cgatgcgtgc atatccagtc tccacgtctc ttcctccatg 3840
atggtttgaa tcgggtaata caacaaccaa agttttcggg cgattgtggt ggtagctttc 3900
acgccttccg tgccttcgtt tggaataccg tggattatat gctgtatctg cagtacgctc 3960
cacatacaca gttctagacg ttgtggagtc ctcgcctgga gtggagccaa tagcttcatc 4020
atttgcccaa tcggtgactt ccaatgcaaa gtcatccgaa ggttcgtctg gtagcaaatt 4080
cataaagtct tcacaaatag tagacacgtc tgggtcggtt ggaattgaag cagaggccat 4140
ggctgcaaaa tatctgacaa ttgcgtgttt gcagttgcct gtatcttccg ccaatgttgt 4200
agaatttata ggctcaccca accccgcaat gggcgtgttt agtcacatga ttaatgtttc 4260
tgggagtttt cactttcccc aaacaagctt acctgcaccc tttgttcgta atgcataaaa 4320
ataaccactg ctatagcaaa tatgacgata taaaaacatt ttatagcaag gccggacatt 4380
actgtagcgc aacatgttgt gcatatacca cgtattcccc ccgtattgat atgatttaaa 4440
tgattatcct tggttggttt tggtctaaca taagatataa gctctactat agcgagcgtg 4500
catacaacaa cccaggccag aatccgaatg tatgtggggt ataataacgc gcatggtgta 4560
tatgcaacgc caagcgttaa aagcacaata catccagatg atatatgagc gataacctcc 4620
aaaagcatca ataacgtaac acctttatgc atatataaaa aacttatagg gtcagcatta 4680
aatactttac tcataccatc ccgtcgcatg gaaacatcac ataacaacct tgccaacttt 4740
gtatatgggt aaccaagaag aatgttcgaa ataacccgtg ttacgtaatt cagtgaatat 4800
gatgtggggg atattaactc acaggatgat cggaatggcc caaacatacg acgtattcgt 4860
cgaaattgta aatacatacc atatacaaac catgcaaaaa aaatcatttt tagctgcacg 4920
caccaaaaat aagcgtgaca attacgtgtt cccagaacaa ttcgaatttt gtcatgcaaa 4980
ggtgtagaaa tagcggtttt taccatagta tctcctgata atagattttc ccggcagctg 5040
taatcgtatc cagataggcc atccaaaaac gttgagtggt ttacaaacgt tacatatata 5100
agagagttgt tataagaccc ccatacaacc ggtccaccat taatcaccgt ggttgcatac 5160
acacactcat gttcaaactt tacacgagcg gtataccata gggtaaaaac agcatgtccg 5220
ctaagtagac acataattat aaaatgttct gtcttgattc ctaaagcctg catgacccgt 5280
ggaagatggc aattcaagca cgatgtagta tcacacggtt ggtgttaact cgaagttaaa 5340
tttggataat taggtacttc tagagtaaag attgtatgca tgcgattgct atcgcacttt 5400
gtagcaaaac attgttgtgc aagcgaaata cacaaacggt tgtgatgatc cactcgcaga 5460
gacacaaatg tccggggagc cgttcttcct ccgcgatggg gatatcgaag acaagtgaac 5520
ccttttgttc cgcatatgag ctgaaataac acccagtccc ttttgatggc gatacacttt 5580
gatgatgtta aggtatattc gcgatcacgc ccggggaaat gaacagcaat atgctccaca 5640
atagattcta atattgtgct gtcgacaaag gcctccagtg taaatgcgtc cagacaagtt 5700
accccgcgct cttttagagc ctttgttaaa gatatttgcg gggggctaaa tatttgttta 5760
ttacgcgcaa ccttacgttc aaaaaactct gcgtattccc ccccaaggtt atgtaaaata 5820
aattgcactg gaacattcga ctgcggtctt gaatgaaaat gaaagtttgc cgggtttcta 5880
tgtgatgtca caaacgctaa tatatcaata cactgctcag gtacaacata aaatgggagt 5940
agttgtccaa ccgccgtccc tgtggttgtt actttggaga aaaaaggcag tcttaaacta 6000
tgtccgtggc tataaacacc agtatctata aacgaaaagt cccgtaaata cggaccaata 6060
tattcaacaa attcccgttc cagcaacacc gcttgctgta atatttgtgc aaaccccttt 6120
aaagtggaag accccactaa cgcataggga tttgggattg gtacgcatac cctgaaacct 6180
attttctctt tacagttaca gggtagagtt tcatgcaagt tttcattgtt tgatacatcg 6240
gcgtgtgtat ggacttcaga cgttgtctgt gtatcaaaaa accatacatc ctctgtataa 6300
ttctcttcta cacacgtgta taattcgcca ttttctatgt aaaaatcgat gtcagaatgg 6360
ctggttatat ccaataaatt atcatcatcc aacacctcaa cggtaggttc aggacatgca 6420
gttttataaa aataacatgg gtctttgtta gggtttacca cggcctttgg aaaaagtaat 6480
tgcatggccg ttaaaatacc atgacgaaat gctcgcatgc cggcatgtaa aatacccaat 6540
gggatgggtt ttcttatatg aaagtctaca tcaagtatga ggtttgtgat tataagattt 6600
gtattaaata gctcattcct gtttatataa agctgatctt tgggtatgtt tgatgaaatt 6660
ttagaaacgt ttttaacaga cgtagataat agtaaagtca actgcatatc tcgtagtgaa 6720
gcggcaacaa aattacatgg attaatttgt ttaaggtcct ccgcaattaa tcgagcctcg 6780
tgcggtaaag tgtaacggtt tgttattgat gaccacgtat cattagcaat aacagcaaat 6840
gcttgggcgc cttgaggcaa ggctacccga tatacaggca ttggtccagt tacctcagaa 6900
tggccgatga gggcttctaa tggagtttta taactcagga tggatacatc atgtgtggct 6960
atcccagtgg cagcagagaa aaacagtaat agttttgtaa tccccgggct cgtatcaaaa 7020
ccagtacgac cactttggtt aggtgtatcg tttgcaaagt tggctgctcg taacgcctcc 7080
gcggaaacaa ccgaatcctc aaaattagac aattcgtcaa aaccgggtgg atttgaggga 7140
atagtggagg accatccata tggactaaat tgtttttcaa tgttttccac acgacgagtt 7200
agcgttgtag ctaggtcaca tacgcctata aacttgctag gttttgcggc atacgtaaga 7260
cttaaagtat atgttttagt aattgtatat ttatgtccaa tctcaggtcc aagttcagtg 7320
acatcacaaa ttacgttctt ttttatatag tcacgcatgt tgagacgaga acgtacatga 7380
ttaaaaaaat tagcagtagc tctttttccc aggttggatg attttaagag gaccggttta 7440
ttcacaaaat ctgagtatgt aaccgcttgt aggtggtctg cgatctgttt ccgattgaaa 7500
cattcaaaat gtgccagata aatataatca acaaattcac ggtctggaac tttaaggcct 7560
tttctatcgt tggtaatata ctccgatact gcgtgtattt ccgttgtgtc tgtatgtatt 7620
cgctgtaaaa tgtacgatag agcatttttg gctgtcaaac ctcgtgtata tgttgaggaa 7680
caacaaaaca tggaaagttt atcaaaagac aacaagtccg aaatattgta cccactacaa 7740
ttaggtaatg ctgggacttg gtaagttaaa aacaaatctt taattgcctg taagtcatat 7800
aagggggttt ccaacgtatt gtaacttgtg tccgtttgta acaagtaata gcgtgtagcc 7860
aacactagcg ttttttcaga gggtccaaat cgaacaatat accaaaacgg cgagcatcca 7920
tacccccagt agagtcgtcg atatgcagcc aatacttgac gttcgtaatg ggcatataat 7980
gatgttagct cctgacgacc aacggatttt ttaactaact tgcagagtgt tgcctctgtg 8040
atgcataggc cgttgtccga taatcccttt cggtttaaat ggtgtgttgt taccatcaga 8100
gtttgtataa cttccgagtg aatgtcaaac gtctccgata tacatagggt atcagatatt 8160
atatgcggat ttaggggtgc tccataccat aacgccttat ataaagcttt aaaatcagtt 8220
tgggttttaa aacaacaaaa aaatataggc cagacccggg atcgtacatc tccagttgaa 8280
aatccaccaa ttaaataaaa aataacgttg acgtccctac tacaaaataa atgcattatt 8340
tggttttctt catcgttttc agttacttca cgtgggcgtt tagttgggat tacttgcgtg 8400
atctcttccc tcccattttt gacaaagacg tcatctaagt cgggagtcca agtataactc 8460
accacataca gaggttctgt gcttatctgc ccggtaagca acaacagcga gtgggagatt 8520
gcacatccct ttgtggcaaa taataaccga atcgtcggtt tggaggattt atccatagtt 8580
caatacgttg gaaagccagt caatcatgca gacggtgtgt gccagcttat gtggatatgc 8640
tcgaatacca actgaagagc catcttatga agaggtgcgt gtaaacacgc acccccaagg 8700
agccgccctg ctccgcctcc aagaggcttt aaccgctgtg aatggattat tgcctgcacc 8760
tctaacgtta gaagacgtag tcgcttctgc agataatacc cgtcgtttgg tccgcgccca 8820
ggctttggcg cgaacttacg ctgcatgttc tcgtaacatt gaatgtttaa aacagcacca 8880
ttttactgaa gataaccccg gtcttaacgc cgtggtccgt tcacacatgg aaaactcaaa 8940
acggcttgct gatatgtgtt tagctgcaat tacccatttg tatttatcgg ttggcgcggt 9000
ggatgttact acggatgata ttgtcgatca aaccctgaga atgaccgctg aaagtgaagt 9060
ggtcatgtct gatgttgttc ttttggagaa aactcttggg gtcgttgcta aacctcaggc 9120
atcgtttgat gtttcccaca accatgaatt atctatagct aaaggggaaa atgtgggttt 9180
aaaaacatca cctattaaat cggaggcgac acaattatct gaaattaaac ccccacttat 9240
agaagtatcg gataataaca catctaacct aacaaaaaaa acgtatccga cagaaactct 9300
tcagcccgtg ttgaccccaa aacagacgca agatgtacaa cgcacaaccc ccgcgatcaa 9360
gaaatcccat gttatgcttg tataaatatt gaaataaaaa ctaaaaacgt ttctggtgta 9420
tgtttttatt ttgtatataa aattaaaaca ttgctggccg gcgtggttat tacatttaat 9480
gttttagtag aaaatcgaca tcgtttgttt ctttatcagt tgaaccaaat ccacgcgttc 9540
cccgttcgct gggtgtggct attagatcta acgttttagt aaaataccat tgtacacccg 9600
gtatgccaca tttaccgcgg atagcataag gaaatgcaat attacttaaa acgttgtgtt 9660
ttaagtgtat ttgggtgttg tgatctatta acaggacctg tgcaagacga tctcccgttt 9720
ttatacgtat gtcatcaccc gtgagattat atacgtagaa tttacagtgt tctcctgcag 9780
gccatgccgt tggacacacg ataatgcctg atcggctttt cgatgatctt ccaaaaatat 9840
aagcgtttat actcggatgt tgtaagtccc agtctcttat aatcggtaag acaattttta 9900
taaattcatt cctttttaaa tataggttat atggtacaca aatatcatat cccgcgtctt 9960
cttggcgttt tggattgatg atatgtttgt aggttaaggg aacatcgata tggtattctg 10020
cagaatccct atgtaaaggt tgcccctgct gtaccgtgga aatatcagca aattcagata 10080
taacgggttt ttcataattt gacggcgagt ttgataaggg ttgaacttgt atcgatttaa 10140
aaattggatc cagatgttta agaacgtttt ttgggagaag gcgactttgt cttaatttta 10200
ccgggaacaa gtagattgtt aaatgtccgg gtaaaataac ggttactcct ggccggtaat 10260
acaaaagggc tgaaattact cctctgtaac ccgcatcaat aactccgttg gcgacaaaaa 10320
aattgtcttc atcagcaagg gcagtatctt tgcattgaat taacaacagt gcgtattcat 10380
tgggaggcgc cgacttaacc aacagctcca actgctgcat ataaaaaccg ccccgtgtta 10440
cagatttttc agatggcagt tcgagtttct tgtggttccg gagtaacaac ggttgatgtc 10500
gacttacttt atcgtctaac acgcattgca gcgtatctgc acattcaggt tgaacttcta 10560
ttaaaattgt atcttttaaa caccgattcg gaatagtttg gctacaaaac atatcacctg 10620
tatttactgc cgtttccaag atgggatcaa ttaccgcttc gttcatatta ataacgatgc 10680
aaattttatt tttttgtgaa gacagcagtg gggagccaaa ctttgcagaa cggaattttt 10740
ggcatgccag ctgttcggct cgtggagttt atatcgacgg atcaatgatc accacccttt 10800
tcttctacgc atcccttttg ggggtgtgtg tagcccttat ttcgttagct tatcatgcgt 10860
gtttccggtt atttactcgt tctgtattac gcagcacgyg gtaaacccgt ttgcctataa 10920
aaggggcagg cgtgtataag agggcccctg tttaatacgc ggtctgccgt gtttggatat 10980
ttcacgaccc tatcgtttat ttacgtaatg gcatcttccg acggtgacag actttgtcgc 11040
tctaatgcag tgcgtcgtaa aacaacgcct agttattccg gacaatatcg aaccgcgcgg 11100
cgaagtgtgg tcgtaggacc ccccgatgat tcagacgact cgttgggtta cattaccaca 11160
gttggggccg attctccttc tccagtgtac gcggatcttt attttgaaca taaaaatacg 11220
acccctcgcg tacatcaacc aaacgactcc agcggatcgg aagatgactt tgaagacatc 11280
gatgaagtag tggccgcctt tcgggaggcc cgtttgagac atgaactggt tgaagatgct 11340
gtatatgaaa acccgctaag tgtagaaaaa ccatctagat cttttactaa aaatgcggcg 11400
gttaaaccta aattagagga ttcaccgaag cgagctcccc cgggagcagg cgcaattgcc 11460
agcgggagac caatttcctt cagcactgca ccaaaaaccg caacaagctc gtggtgcggt 11520
cctacgccat catataacaa acgcgtcttt tgtgaagcgg tccggcgcgt agccgccatg 11580
caggcacaaa aggctgccga agcggcttgg aatagtaatc ccccaaggaa taacgccgaa 11640
ttagaccgtt tgttaaccgg agccgttatt cgtattacgg tgcatgaggg tttaaattta 11700
atacaagccg ctaatgaagc agacctaggt gaaggagcat cggtatccaa acgtggacat 11760
aatcgaaaaa ctggagattt acaggggggc atgggtaatg aacctatgta cgcacaagtt 11820
cgtaagccaa aaagtcgaac ggatacacaa acgactgggc gtataactaa tcgaagtagg 11880
gcccgttcgg catcaagaac tgatgcgcga aaatagggat ataattacgc agtaacggtt 11940
tacccggtat tatgtataat aaataaacgt ataaaagaca gtcgtggttt gtgtttatta 12000
taaatgtgta ttatatgtca catattataa actgtttaaa tagtaccacg tggtattatg 12060
aacagtttat aatcagttgc taccaaacaa accccattag acggcgggtt ttgataaagg 12120
gaatcgctta tttaaactaa agattttact ctataagtat ggagtgtaat ttaggaaccg 12180
aacatcatag tacagatacg tggaatcgta gtaaaacgga acaagcggtt gtggacgcat 12240
ttgatgaatc gttgtttggt gatgtagcat cggatattgg atccgaaacg tcgttatatt 12300
cacatgcagt taaaactgct ccgtctccgc cttgggtagc tagccctaaa attttatatc 12360
aacagttaat acgggatctt gatttttcag aagggccgcg tttactatca tgtcttgaaa 12420
cctggaacga ggatttattc tcatgttttc ctattaatga ggacctatat tccgatatga 12480
tggttttatc cccggatcca gatgacgtta tctcaaccgt ttcaaccaaa gaccatgttg 12540
aaatgtttaa tttaacaacc cggggttccg ttcgattgcc tagtccacca aagcaaccga 12600
cggggcttcc agcttacgtt caggaggtcc aggattcgtt taccgtagaa ctacgcgccc 12660
gggaagaagc atacacaaaa ctactagtta cttattgtaa atcgattata cgttatctcc 12720
aaggaacggc gaaaaggacg acaataggtc ttaatataca aaaccctgac cagaaagytt 12780
acacgcaact caggcaaagt attctactta gatattatcg tgaggtggca agtttggcgc 12840
gtcttctgta cctacattta tatttaaccg taacgcgtga attttcctgg cgtttgtacg 12900
ccagtcaatc tgcacacccg gacgtgtttg cggctttaaa attcacctgg accgaacgtc 12960
gacagttcac gtgtgcgttt catcctgtat tatgcaacca cggcattgtg ttattagaag 13020
ggaaaccact aacagcgtct gccttgaggg aaataaatta ccgccgccga gaactgggac 13080
tgcctctagt tagatgtggt cttgttgaag aaaacaaatc tccgttggtt caacaaccct 13140
cattttcggt tcatttacca cggtcggtgg ggtttcttac ccaccacatt aagcgtaagt 13200
tagacgcata tgcggtcaaa catcctcaag aaccgagaca tgtacgagcg gatcatcctt 13260
acgcaaaagt tgttgaaaat agaaactacg gtagtagcat cgaagctatg attttagcac 13320
ctccgtcccc atccgagatc ctgccggggg acccaccacg cccacccacg tgtgggtttt 13380
taacgcgtta aacgtcattg gggtaaaggg tgtaaataaa ttacgaaaac gtgcatgcgt 13440
tttttatttt tacaatgcgc cgtatatggt atgtctgtca tgtgctctaa agtcccatat 13500
ataaaagaag ccccaacgag tgtatgcgta ttgcgtaccg cgaccctggg atgttttaca 13560
ggcgcgtttg tttgtctcgg ttataagtat gcagtcgggt cattataacc ggaggcaatc 13620
ccgccgacag cggatatcgt ctaataccac agactccccc cgtcacacac acggaacacg 13680
ttatcggtca accaattggt atacacaccc accccagata ttgtccaatt cagaaacatt 13740
agttgcggtt caagaactac tgaactccga gatggatcag gacagcagtt ctgacgcatc 13800
ggatgatttt ccgggatacg ccttacatca ttctacatat aatggatccg aacaaaatac 13860
atcaacttcc agacatgaaa atcgcatatt taaattaacg gagagggaag ctaatgagga 13920
aatcaacatc aatacggacg cgatcgacga cgagggagag gcggaggagg gagaggcgga 13980
ggaggacgcg atcgacgacg agggagaggc ggaggaggga gaggcggagg aggacgcgat 14040
tgacgacgag ggagaggcgg aggagggaga ggcggaggag gacgcggcgg aggaggacgc 14100
gatcgacgac gagggagagg cggaggagga cgcgatcgac gacgagggag aggcggagga 14160
ggacgcgatc gacgacgagg gagaggcgga ggaggattat ttttctgtaa gtcaagtttg 14220
cagtcgagac gcggatgagg tttattttac gttagacccg gaaataagtt acagtaccga 14280
tcttcgcatt gcaaaggtta tggagcctgc ggtatcaaag gaacttaatg tatcaaaacg 14340
ttgcgttgaa cctgttaccc taacaggctc tatgttagcg cataatgggt ttgatgagtc 14400
ctggtttgct atgcgcgaat gtacccgtcg cgaatatatt acggtccaag gattatacga 14460
cccaattcat ttacggtatc agtttgatac ttcccggatg acacccccac agattttgag 14520
aactatacca gcccttccta acatgacact tggtgaactt ttattgattt ttcctattga 14580
atttatggcc cagccaattt ctatagaacg tattttagtt gaagatgtat ttttagatag 14640
gcgggcttcc agtaaaacac ataaatacgg cccgcgttgg aattccgtct acgcacttcc 14700
atataatgcg ggtaaaatgt atgtacaaca cattcctggg ttttatgacg tgtccttacg 14760
tgctgtgggc caaggaacgg ccatttggca tcacatgata ttatccacag cagcatgcgc 14820
tatttctaat cgcatttcac atggagatgg attaggattt ttgttagacg cggcaattcg 14880
tattagcgca aactgtattt ttttgggacg taacgataat tttggcgtgg gggatccatg 14940
ttggttagaa gaccatcttg ccggattacc acgagaagcc gtacccgacg tactccaagt 15000
gacacagttg gttttgccaa atcggggtcc aacggttgcc attatgcgtg gtttttttgg 15060
ggcgttggca tattggcccg aactaagaat tgctataagt gaaccatcta catctttggt 15120
gcgatatgct accggtcaca tggaacttgc cgaatggttt ttattttcac gtacacatag 15180
tttaaagcca caatttaccc caacggaacg ggaaatgtta gcgtcatttt ttacgttgta 15240
tgttactctt ggtggaggaa tgttgaactg gatctgtaga gcaactgcaa tgtatttagc 15300
tgctccttac cattcccgtt cggcttacat cgcggtctgt gaatctctgc cctattacta 15360
tatcccggtt aatagtgacc tgttatgtga tttagaggta ttactgttag gcgaggtcga 15420
cctcccaact gtttgtgaat cctacgcaac tattgcacac gaattaaccg gatatgaggc 15480
tgttcgcaca gcagccacaa attttatgat agagtttgcc gattgttata aggaaagtga 15540
gaccgattta atggtaagcg cgtacctggg ggccgtttta ttgttacaac gggtgttggg 15600
tcatgcaaat cttcttttgt tgcttctctc cggtgctgcg ttgtacggag gatgttcaat 15660
ttacatcccc cgaggtattt tagatgcata taatacttta atgttggcag caagtcctct 15720
ttacgctcac caaactttaa catccttttg gaaagaccgc gatgatgcaa tgcaaacttt 15780
ggggattcga ccgacaacgg acgttttacc caaagagcaa gacaggatag ttcaggcatc l5840
acctatagag atgaacttcc gttttgtggg attggagacc atctatcccc gagaacagcc 15900
cattccctcc gtggacctag ccgaaaatct tatgcaatac aggaatgaaa ttctgggttt 15960
ggattggaaa agcgtagcca tgcatttact acgaaaatat taagggttgt gatttttttc 16020
attaggatga aaagaacgtt tcctagccac acccacaaag gagtttgtaa aataaaatct 16080
ctgtttagac cttaaaattt gttgtgtgtg ttgtgtgggg ggtccgtgag gatcgacctt 16140
tacaagatat aatttgtcca tatcgcaatg ttttctcggt ttgcgcgttc cttttccagc 16200
gatgatagaa cgcgtaaatc ttatgatggt agttaccaaa gttttaatgc cggcgaacgt 16260
gatttgccca cacctacccg ggactggtgt tctatttccc aacgcataac cagcgagcgc 16320
gtgagggatg gatgtcttat tccaacgccc ggcgaggctt tggagacggc ggtaaaggct 16380
ttatctgaaa agaccgacag cctaacatcg ccggttttac aaagtaccga aagacacagt 16440
gttctgcttg gattacacca taataatgtt cctgaatcgt tggtggtctc gtgtatgtct 16500
aacgatgttc atgacgggtt tatgcagcgt tatatggaaa caattcaaag atgtttggat 16560
gacctgaaac tttctgggga tggactttgg tgggtttatg aaaatacata ttggcagtat 16620
ctcaaataca ccacaggagc cgaggtaccg gtgacttcag agaaggtaaa taaaaagtct 16680
aaatccacgg ttttgttgtt ttcatccgta gttgccaata aaccaatatc cagacatcct 16740
tttaaatcta aagttataaa ttcggattac cggggaatat gtcaggagct acgtgaggcg 16800
ttaggagctg tgcaaaagta tatgtatttt atgcgtccag atgatcctac aaaccccagc 16860
ccggatacaa gaatacgtgt acaagaaatt gcggcttaca cggctactgg ctacgggtgg 16920
atgttatggt tcttggacgt tgtggacgcc agggtatgtc gccatctcaa acttcaattt 16980
cgacggattc gagggccgcg cgcgtctgtt attccagatg atttgcttag acgacattta 17040
aaaacgggtc ctgcggtctc agcgggcaca ggagttgcgt ttattttagc agcaacaact 17100
gccagcgctc ttactgcgct tttgcgtatt agtgtattat ggcgaaagga agagtggcgg 17160
gatggtttaa atggaaccgc agctgcaatt gttgcggcgg ttgaacttat tacgcttttg 17220
caccaccatt ttcaatactt aattaatatg atgcttattg gatatgcatg ttggggggat 17280
gggggattaa acgatcctta tatattaaag gcgctacgtg cccagggacg gtttttatat 17340
tttgcgggtc agttggttag aacaatgtca acacacagtt gggttgtgtt agagaccagc 17400
acccatatgt ggttttcccg ggccgtggcg cagagtattt tagcacatgg gggtaaaccc 17460
acaaagtatt atgctcaggt tcttgccgcc agtaaacggt atactccgtt acatttaaga 17520
cgtatatccg aaccatcgag tgtgtctgat cagccgtata ttcgttttaa tcgactggga 17580
tctccaatag ggacaggtat agggaatttg gaatgtgtct gtttaacggg aaattattta 17640
tctgacgacg taaatgcaag ttcgcatgta attaatacag aagcaccgtt aaacagtata 17700
gcacccgata csaatagaca gcggacttct cgcgttttag ttcgtccaga cacgggtttg 17760
gatgtaactg tccgaaaaaa ccactgtttg gacataggcc atacggacgg tagtccagtt 17820
gacccaacgt atcctgatca ttacacccgg ataaaggcgg aatatgaagg tccggttcgg 17880
gatgastcaa acacaatgtt tgaccaaaga tcggatttac gtcacataga aacccaagca 17940
tctttaaatg atcacgtata tgaaaatata ccacccaagg aagtgggttt taactcatct 18000
tcagacctgg atgtggatag ccttaacggg tacacttccg gagacatgca tacagacgat 18060
gacttatcac cagattttat acccaacgac gttcccgtta gatgtaaaac cacggttacg 18120
tttaggaaaa atacgcctaa gagtcatcat taagtacagc ggttaataga tagttatgga 18180
ctaggcactt tggcggtcat ttccacaacc aggttaaaat tgggggattt gggagaaaat 18240
agtctattgc gtattttctg ttcaataatt ggactgcgtt atttaaaggt ctgattggtt 18300
gattgggtta taaaaggaat tactccttta aattttactt aatgtaccca caatatcaag 18360
tggtcgtttg tatttaacga ttattaccgg taccatggga gacttgtcat gttggacaaa 18420
agtgccgggt tttacgttaa ccggcgaact tcagtactta aaacaagtgg atgatatttt 18480
aaggtatgga gttcggaaac gcgatcgaac aggaatcgga acgttatctt tatttggaat 18540
gcaagctcga tacaatttgc gaaatgaatt tcctctttta actacaaagc gtgttttttg 18600
gagggccgtc gtggaagagt tgttatggtt tatccgcggg tcaaccgatt ccaaagaact 18660
cgccgctaaa gatatacaca tatgggatat atacggatcg agcaaatttc taaataggaa 18720
tggcttccat aaaagacaca cgggggacct tggccccatt tacggcttcc agtggagaca 18780
ttttggagcg gaatataaag actgtcaatc aaactattta cagcaaggaa tcgatcagct 18840
gcaaactgtt atagatacaa ttaaaacaaa cccagaaagc cgacgaatga ttatatcgtc 18900
ttggaatcca aaggatatcc ccttaatggt actacctcca tgtcacacgt tatgtcagtt 18960
ttacgttgca aacggtgaat tatcctgcca agtataccag agatcggggg atatgggcct 19020
tggggtaccg ttcaacattg ctggatatgc acttcttacc tacatagtag cgcatgttac 19080
aggacttaaa accggagatt taattcatac aatgggggat gcacatattt acttgaatca 19140
tatagatgct ttaaaagtgc agctagctcg atccccaaaa ccttttcctt gccttaaaat 19200
tattcgaaat gtaacagata taaacgactt taaatgggac gattttcagc ttgatggata 19260
taatccacac ccccccctaa aaatggaaat ggctctttaa tggattttta aatgttgtca 19320
agacagtaga tgtgttgcga atgtaataaa atgatataca cagacgcgtt tggttggttt 19380
ctgtytatga acagcaacgg atgcataggg ttgcgataac tgcgataaga cccaatgtcc 19440
caaggataga tatcacacca attataactg ctacaacgga aaatgtagtg gcgtaggtag 19500
atgcatcgta ggtataaacg gccgaaaacg gagggaattt tttagggtaa ccatctagat 19560
gacacgaata ggtgataggt ccgtcgagtt ccgatgttgg acaagaactt tgcatgttta 19620
caaaccgttt gttttgatca cacaccccag taatctcact gttttcgtgg ttgatgggag 19680
aatcgttaac ccaccatacg aaatgtacaa cgccacgtgg cacacatttt gccgtacata 19740
ctatgtgtcc atcaataata cctatagaca cgttgggaaa tggatagacg tcaggggtaa 19800
cgacagcaga atatttcata ttagagacgc catcccgaat ccataaaaca ttacattgga 19860
tggctggggg tgggtaatcc atttgttttt gctgtggaat tcgtaccgcc gaaacataac 19920
taaataatcc attggcatat tcttgtattg catcggttat aaaatttttt ccgatgttac 19980
caaaccttga agtccaccga acacgtaccg agtgcggtgg ataatacttt gatacgttac 20040
agtaggctgc gtatgtctgt ccggttaaga ctggatcgcc gacaacggta atatttggac 20100
gataatacgt tgtaactgta atactgtgtt ccgatatgac gttcttagtt tttgtattaa 20160
cgactcgcca aatatacgtt ccctccgtgg tagcatccat agataaaatt gttacagaaa 20220
aatcagacgt tgttttaaca tctggtatta cataattttc cttagcgtgt gtaaatatct 20280
cagggttgtt tattaagttt aaatcggcac tgttgctata taacataacc ggtaaatctg 20340
gcatgcgtat taacgcattg cccagttgac ggtgcggatc tataaggtga cgcgtaaacc 20400
aaacttcaat atgaagatcg gggcgtataa gcgacttcca ccttgttata tttgaacctt 20460
ccggatctaa agaatattgt tcatatgttt tttgttgctg cttaaaggcc gcctgttgtc 20520
cggtcgttag acgcatgtaa caaggcatga taaatgtgtg aaaatagggt atggattgta 20580
ttccgccgtg aacgcattgt atattttcaa atagaaaagg tggttgtgaa tgttgggcgt 20640
tggctgcggg atcgggcttt cgggtagcgg ccgaggtggg cgcgacggcg ggatcgggat 20700
ttcgggaagc ggccgaggtg ggcgcgacgg cgggatcggg atttcgggaa gcggccgagg 20760
tgggcgcgac ggcgggatcg ggatttcggg tagcggccga ggtgggcgcg acggcgggat 20820
cgggctttcg ggaagcggcc gaggtgggcg cgacggcggg atcgggcttt cgggaagcgg 20880
ccgaggtggg cgcgacggcg ggatcgggct ttcgggaagc ggccgaggtg ggcgcgacgg 20940
cgggatcggg ctttcgggaa gcggccgagg tatataattc agttatactt acgggtgtgg 21000
gttgagattc agtcgataat tgtatacacg cgatcgttaa aattaaattt atttgtatcc 21060
gcttcatcct ggtttttatt gacacatcca cgctcccctt aaataaaaga ttaaaacacc 21120
caccgcggaa tttaaatgat ggaaacgttt ttttcgacat tgggaataat aaaaacggct 21180
tttgcaactt taaaaacttt atttatctcg attacgatac atatgtacca catagatagc 21240
atagatttat tataatataa acacacacgt gatatacttt agtgatatga gatgccataa 21300
aacagtcaat aggtttaacg cttaatctca tcatctgaat acacgtcaaa cccgccgcaa 21360
ctgttgatgt tagaattata atagctcccc atgaaatgcc ggcaaatgtt acagctatac 21420
ccgtcaccga ggtcgttgta tataatacaa ttacccatag gttttttttt tcttgatata 21480
aaacggcaaa accctgtaac ccaaatgcta taatatgacc tcctattgaa actgctaacg 21540
ttacttgtgt aagtttgata aaatgattta atttaattat atgtgagatt gcccacatta 21600
atggggtaac tatatataac accgggggta taacagacat tatacgaatt cctttaaaca 21660
cgcgtttaag ggtccgggaa ctttctctat ggtcacatac tctcccgcgg tcattttgtg 21720
tatatacaac ggcaaaacct aaatctgtat aagtgtttaa ttgcttatgg cgatttttac 21780
gatatataca cgtatcttgc aaatcggtgg cggcatcgac aattgaaact agtgtgacaa 21840
tagatataca caatccaata agaacctcat atttactgac atacatatat aaaataacgg 21900
ttagtaaacc tcccaaccca gttcccaaca tcataacata aaaataaata tgcggtccat 21960
tgaatgtcgt aacaaagttg tagtaatgga tatgcacagc agccactgtt ccggtaatcg 22020
cggatatgga aattcccagt aattctacaa atggaagatc ccgggatatt gggcaaccaa 22080
ccgcccataa cacagcaaaa cccaacacga ccaccgtctg caaacatcgt cccaattttg 22140
ctaatgtgcg tagaaatttc acggatgttg gccataaccc cgaaacgacg atcaacccca 22200
taatagttgc attgacggca gcttcgcaga cgtgatattg taaaattaac ccggacgtga 22260
taacacttgc ttgtagtccc acgagaaaca accgcgatgc tgaggttatt gcacacgaat 22320
tacattcttg agggtttccg acacatcctt ggattgattg agcgcggatt aattctctgt 22380
ctaacacacc caggttttca tcatggacag ctctttcacc attcacggcc atgtcttaag 22440
tttaataatt caaaacagat aaaaatgtgt tcatctatgg tacacacaag tttgtatgta 22500
aaatataagc aaaagttgca cttatttaac tgtacatatt acgtcagatt cacgtgataa 22560
ttcagaataa tccagggttc ctgcagggtc cactggagga gccacacaat attcgcgaat 22620
tccgattccc tcctgccatg tggtttcggg gagtttcccc cccattttat ttccggtatt 22680
tttttcgttt ctttttgtta ataaattgcg tctttttttt aatggtggtt catccttcac 22740
agattccgtg ttcgcaaata attgcatcga ggttaatttt tctttaaggt ctttgggact 22800
taagaacgtt gcataaaaaa aagaatgcac gggtgcggaa cgttggatat acaatccaac 22860
catgggggag ttagttaagg cgagataaaa attaatataa cacgtctcat cccgtgttaa 22920
cttaagattt tgtacggcag aacggaatcc actgtgtgtt tccaataata ctccaaattc 22980
acgcatactc ccgctgccat aaacaacatt attaaggatc ctttttgaat ttgtgattga 23040
gcgtattaaa ttatatggtg taggcttgct tccgtttata tccaaggaaa cattaaatga 23100
gataaaacca cccccggcgg tctggatgta catatccgtg gctgttagaa tgaagcatgt 23160
tgtaaaccca aaagttttaa gtagtcgctg taaacgggtg aattgatcgc gttttaagca 23220
aatgcttata tctggagtta gatttgggaa catcattgta taacaagcga gttcacgttt 23280
tacaacttgt ttgtaacatt gtacttgatc atctggacca caatcacccg ggcgttgcca 23340
taccatcgtt tggataatac tccgctcggg gggttgtccg gtaaatttaa aatataaccg 23400
tgttggggtc gacggatctt ttgtatggcg aaacgcgtca ataagcgagg accgtccctc 23460
cgttgccgcg agtacaacca ttctcggccc agtccaatta tactggtcaa acatatttgc 23520
cggtatagga atatacagtt gttctgtttc caaactacag tgaataatta atccttcgtc 23580
gctgaatatt aaaatagaat cccttagtct attaaccaga ggtgatatag acgaaattaa 23640
accagtaagc gttttttccg ttaaaacagc tctggcgatt tctggggcgt caaaacccgc 23700
atgcaattcc atgtccaaag catcgtctgt acgcgacctc aaatccataa tttactactt 23760
aaaatgttta ctatagaaaa agtaatcata tgtaaacaca cgagtttcgt taatatgttt 23820
gtttaacccg atccggtgac ttaagtacat aaacaggcat gatatttgaa tagtacggcc 23880
catgggaggg aacatttcca cgtgttccaa tacagggggt gttccttaat agggactgtg 23940
caataaaata cgtaagaagt taccagattt gatgtaatgt ttgtcataaa aaatatgtac 24000
atcattatat acgtctgtaa ttaacacaag atcacatcga agaattactg aagccgctgt 24060
gaaacctttc acaagacgat ataaacttgg ttaagtgtat tgatggggct ctttggactg 24120
acacgcttta tccatgaaca taaactggtt aaacccagca tcatttcaac gccacccgga 24180
gttttaaccc ccgtggcggt agacgtatgg aacgtcatgt acacattgtt ggaacgttta 24240
taccctgtgg gtaaacgcga gaatttacac ggaccatctg taacgataca ttgtcttgga 24300
gtcttattgc ggctattaac acaacggtca tactatccga tatttgtatt ggaacgttgt 24360
acagacggcc cattatcacg tggagccaag gcaattatgt cacgggccat gaaccacgat 24420
gaaaggggaa cctcggactt aacccgtgtt ctactatcat ccaacacatg ttctatcaag 24480
tataacaaaa catcggaaac atatgacagt gtgtttcgaa actcttccgc gagttgtatt 24540
cctagcgaag aaaacaaatc ccaggatatg tttttggacg gttgtccacg acaaactgac 24600
aagatgatct gcctgcgcga ccaaaacgta tgcagtctta cctctacaat gccatcccga 24660
ggacatccta accatcgatt atatcacaaa ttgtgtgcaa gtcttattag atggatgggg 24720
tatgcatacg tcgaggcggt tgacattgag gcggacgagg catgtgcaaa cttatttcat 24780
acgcgtacag tggctttggt ttatacgaca gatactgatt tactcttcat gggctgtgat 24840
attttgttag atgcaattcc tatgtttgct ccagtagtac gatgtcgcga tttgcttcaa 24900
tatttaggaa ttacataccc tgaatttttg gttgcctttg ttcgctgtca gaccgatttg 24960
catacaagtg acaacctaaa atctgttcag caagttattc aggataccgg cctgaaaatt 25020
ccacatcaaa tggacacttc aacgcgctcc cccacttacg actcgtggag acatggcgag 25080
gttttcaaaa gtcttaccgt agccacgtcg ggtaaaacag aaaacggagt gtccgtttcc 25140
aaatatgcat ctaaccgatc ggaggtgaca gtagacgcca gttgggcttt aaaccttctg 25200
ccaccctcat cctccccatt ggataatttg gaacgcgcat ttgttgaaca tataatcgcc 25260
gtggtaactc cattgacccg cggtcgccta aagttaatga aacgtgtaaa tattatgcaa 25320
aatacggcag acccatatat ggttattaac accttatatc ataacttaaa gggggaaaaa 25380
atggctcgcc aatacgcacg tatttttaaa cagtttattc ctactccact cccactaaac 25440
actgtattaa caaaatattg gaattaaaac acacataaga gcgacttaat ggttcattgt 25500
tttattttgc tcgtatatac atgttataaa tcgtttatca ctgtgcccgc ataagatgta 25560
ctgtgtctct caaaaaaatt tgtgttttta tctgcaatca taaatgcaag tggaaagtcc 25620
gaatcgggag gtggggtgtt aaatagtttt ggtacattaa tcgctgataa aagcctgtcc 25680
gcgctgaatt tcacgtattg tgtaattgca tcgacgttca ccaaacgggt tttgggtgca 25740
tgggatttta aaaacgcaca ctcgatttca acggcttccg aaaacagttg atgtattctg 25800
gtgatagcgg gtttttcggg tacatagtta ttgtatatac aacacgatgc gctggtatgt 25860
atggcttcat ctcggcttat aaggtcgtta aattgacaag ttacaacaaa tagtccgtta 25920
ttgcgtaaat atgcaatagc cgcgaacgat gatacaaaaa aaatgccctc tataagaatc 25980
attagtatat atttttctgc aacggatggg ttgtcccgta ccttttcttc caaccattgt 26040
actttttgtt ggatcgacgg attattaata gtgacgttta cgtattgtac ccgcaacgat 26100
tcatcccctc tgaacaacat tagttgaatt tgactataga cacgcgcgtg gacaacctcg 26160
atgcactctt gttcaatgta gtaatggtga atatcctttt gggaaaagag ttgggttaga 26220
gagcccaaat taacatttac cagatcatct gccgccgata aaaatgtaaa aataaatctg 26280
tagaatatta gttcatcttc cgttaaacag tccaagtatt gataatcatc ttcaatgata 26340
aaatcgcttt ctaaccaacg attcgaaatg ctcagggcac gtaaattgtt tatatctgga 26400
cactccggcc tgtaaaaaaa atgactgcaa tctttctgat ccattttgga atagtttccc 26460
gtgtaaattt ataaagcaca actggtacag gttaattcgc ctcccgcaaa cagtccgctg 26520
ttcgtagctt tacgaatttt acagtagtac atacccgttt taaggccggc tttataggca 26580
cgtataagca aattcattat tttggaggcg ggaattgtcc cgtctgggcg ttcctcaata 26640
aataaagtca ttgattgact ttggtcaata aatggcgccc tttctgcaca catatcaacg 26700
agatcctctt gctcatattc aaacgctgtt ttatatttta agagtgggtg actattagat 26760
aaacagccaa acgaacgtat tactgaccat tggtttttct caagtatgtt tataacttcc 26820
agtcgttttt cttcacatga atacatatct cttagttcgt ccataaggtc taagttgggt 26880
ctaagtaact cacccgaggt ggtgacctta ctaaacatat tattataaat tggagagaaa 26940
ccctcactgc actccgttac ctgtgcagat gaaactgtgg gcattaacgc taagaactgc 27000
gagttgtata acccataagc gcaaatatca tctcgcaggg tacaccatgg taaatctaaa 27060
taacttatcg tagaaaaccc atcttggtgt aaccatccct tagcatattt actttcggta 27120
aaacccttaa acggggctaa gccgccaatc ttacacattt ccatgcttgt tttcattgtc 27180
tcatacaaca ttaactccgc tatttgtaca tttaaccgtc tagctggttg ggaagttaaa 27240
tcaaatccta agcggagaca agttgtatgt aacccttgta tgccaatgcc aagtgatcgg 27300
ttgtttttta cacctttaca tgatttttta catggaaagt tcccagccgc caggaccccg 27360
tttaaaaaaa taacagtcgt tcttgctgtc aattgaaggt cgtttaaatt aaatgacact 27420
gggcctttgg ataagcacgt tgtaagattt atgctggcaa gattacatac gccgtgttga 27480
tgagcgtctg ccttttgaac aatttccgta cacaaatttg accccgtgat agcatttcct 27540
tgggtattca tatgataatt acgattacag gcatctttga acattaaaaa ggggcttcct 27600
gttacagcag cactgcgtat gattgtgaat gcgatatctt gaatgggaac agaagaaacg 27660
cctaatcctt ctctctctaa acgtaaatag gttgaagtga atgcctcccc gtgtaatgtt 27720
cgaaggatat cggctctgtt atcaaaaaga gtccactgaa cattactagc cccttttaga 27780
tagcttaggt atctttcaaa aaataaatct ggggtccata aacaacaaaa tatgttatca 27840
catcgaaata tttcatcacg aaccaacatt ccacgtgtgg ccaaaacagt ttgtagatcg 27900
acgtgccatg gttctatgta aacacaaact ccagttggtc gttcacaatc actgttaatt 27960
gccataacca tgcaatctaa aagttttaaa actgcaagaa gacctttcgt ttgattttcc 28020
gtaggtatta aattcagact ctgtagagaa attcccactc cacctcgact ttgtaatacc 28080
gttcccacat cgcctgtgat agctcgaaca gctctcccaa cagtgatgga ttccgggtcc 28140
attaaataac aactggccgt tgccccggtc tctcgaccta aaaacatcat aaccggtgta 28200
gccgggacaa ttttctgaca tgccaacgct gtgaaaaata cccgacagac atcagtccat 28260
gtataaccat catttattcc gggaataaga gttgcgattt taggcaggtt tacgatttct 28320
gttgtcacgg tggccgccag tcttaaaaag aattggcaaa gcgactctaa tttaccttcc 28380
tctaacttag ttaaataaaa gtcttcgtac tttaaagcag actgtagtcc aagggtagct 28440
aaagcggggt attgatcttt caaaaacggt tctaatatag cccgacgaat ttcgtccctc 28500
cgcccttcaa ttgcttggcg gactcgggga gttaaacaga gaattgggga agtcaaccac 28560
gtttccatgg aaacggatcg taggttaata cggcaatgga taagttctcc acaacatcgg 28620
tacactcgct catcttgtcg cgtcaccgcc ttaagttttg agacgatagt gctaatatac 28680
tccattaatt ccaccggtgt ggttgattcg ggcggaatga tgtattcctt gtagccatgt 28740
tgacataatc ggtttataat gtcatgaacc gtattaaaaa ttcttttgaa ctccataacg 28800
gataacgtat ttaggctccg gaataaacct ttaaacccta aactcacagc tgagttagtt 28860
ctacaatatt gtagactccc ttatatatgg ttacgtacag cctgcccctc cccagtatat 28920
aatatcacgc aaaacccacg ctatgttaaa ttcagtttat tttacataca tgctttaata 28980
ataacattcg ttccatgtat ttgtaccccc ccacacaacc ccctctaacc aaatagttgg 29040
cacgttataa cctccgaacc gttccatgcg tcttgtataa cgcacagact ctgatggaat 29100
tgttccaatt aacgtatatg ccgcatacat gcaggataat tgtgtgggaa ggccccgaaa 29160
atcgccggtc cattgataca atcgctgtct agccaagttc caatttactc ctgtaatttc 29220
gccaatacta catcgagggc ttgtcgggtc attggataac tgcacaagcg gcaacgccct 29280
tgtgttatat ggctggtggg tatttgcaac cccttcagtc ccccaggcgg cattttcagc 29340
tcgtatgcgt cctaacagga agccaatacc acgaccaaaa cattgttcgt ttagttggct 29400
taatgcaaga tgcagtctta caccttctcg ttggcgtcgc tgtgtatata caaaaaccaa 29460
gaacacatgc ttcagtccgt ccgcggaaag atgtaaatct ttgtcaacgt cccaaaatac 29520
gcaggccggg atgttggctg tgaccctgcg agttgaagtt ttgtctgtac gtgcagcttc 29580
ttggggacct ttggccacgg cggttatatt gcataaatta tcctgaatgg tatattccag 29640
cagggaccca aaaaaactta taaatcgatg tggaaataca tgacattgta ccatcgcacg 29700
taaacactcc gaaaacctta tgagccgcgt ttccatacga ctgcatccat aggcagaaac 29760
aattgctgtt ctgttggcat ccgctgcctg tttatccgta tattcttctg cccggcatgc 29820
ggcgatgaaa cttaatgacg ttacatatgc tctaagcccc ccaccttctc caacggtcca 29880
aggagccgtg caggcattga ataggtttcg taaaccctct agtagtacat cggggtcacg 29940
tccagcctgt gtaagtgtat tagcttctcc aatcatgtca gatggatgac gaaggattaa 30000
gacgattgac ccagcatgct caatgtccgg acgaaaaaaa tcggttaatg acacttgttg 30060
gattagctgt gtcgttgatt taaaattatt taacgggagt ctaatggtaa cttgcgggtt 30120
accaattgaa gttggattta tttgaatgtt gttcatacga ttaataacaa ttgaacgggg 30180
ggttacttga atagacgcgg tttctgtacg ttttggtggt acatgtatcg gttgtttgtt 302740
cagacctcca aagcgagggc caattgttaa atcgcgactc caatttccga agaagcccgg 30300
agcataagtc atatgaagcc cgttccctat ttgaataaaa cggttatttc ctaaaagact 30360
gatattagtt ccacatagcg tttgttcgtt taaagtaaaa tgcgagttgg ttggttgact 30420
ccccatagct gaggggttaa attcacacaa tgcaatcgtg acgtggtact atctgaaatg 30480
ttgcctgggg tatgtgtaca cattatacag tcgtagtacc gtttatataa tgttaggtag 30540
gaggagccta taaaaatatt ttgattggcg ttaaaaggtt cttcaactta ccgtgacgtc 30600
ctttttatta acatgcgttt ttattgatgt tacatttatg tcttttcatt ccggacggat 30660
gtagcttttt catatcacgt tataaagtta agtcagcgta gaatatacca tggaagaacc 30720
aatttgttat gatacacaaa aacttttgga tgatttaagt aacttgaaag tacaagaagc 30780
ggacaacgaa agaccatggt caccagagaa aacagaaatc gccagagtta aggtagttaa 30840
gtttttacga tctacccaga aaattccagc taaacatttt attcagatat gggaacccct 30900
gcattctaat atctgttttg tatattccaa tacatttttg gcggaggctg ctttcacggc 30960
cgaaaattta cccggactgt tgttttggag actagatcta gactggacga tagaggagcc 31020
aggtaatagc ttaaaaattt taacccagct atcaagtgta gtacaagatt ccgagacgtt 31080
acatcgttta tcggccaata aattacgaac ctcgtctaaa tttggacccg tttcgataca 31140
cttcattata acggactgga taaatatgta cgaggtcgcc ttaaaggatg caacaacagc 31200
cattgaatca ccattcactc acgctcgtat tggaatgttg gaaagcgcca ttgcagcttt 31260
aacacaacat aaatttgcga tcatttacga tatgccattt gttcaagagg ggattcgtgt 31320
tttaacacaa tatgcaggat ggcttcttcc gtttaatgtt atgtggaatc agattcaaaa 31380
tagctcactc actcctctaa cacgagccct ttttataatc tgtatgattg atgaatatct 31440
cacggaaacg ccagtacata gcatatcaga attatttgca gatactgtaa atttaattaa 31500
agatgaggcg ttcgtatcca tcgaagaagc ggtaacgaat ccacgaacgg tgcacgagtc 31560
acgaatttcc tcagctctgg cttatcgaga cccttatgtt tttgagacat ccccgggaat 31620
gcttgctagg agacttagat tagacaatgg tatatgggaa agcaacctct tatcgttgtc 31680
cayccccgga attcatattg aggcgctgtt acatttacta aactccgacc cggaagcgga 31740
aaccacatct ggaagtaatg tagcagaaca cacccgtggc atttgggaaa aggttcaggc 31800
tagtacatcg cctagtatgt taataagcac ccttgccgaa tccgggttta caagattttc 31860
atgcaaattg ctacgtcggt ttattgctca ccacacactc gccggtttta ttcacggaag 31920
cgttgtagca gacgagcata ttacagattt ccaacaaaca ctaggatgtc tcgctttagt 31980
gggtggactg gcataccaat tagtggaaac gtacgctcct actaccgagt atgtgttaac 32040
atatacacgg acagtaaacg agaccgaaaa acggtatgaa acgctattac ccgccttagg 32100
attaccaccg ggaggcctgg gacaaattat gcggcgctgt tttgctccac gaccccttat 32160
tgaaagtata caagcgacac gcgtaatact acttaatgaa atttcacatg cagaagctag 32220
agaggcaaca tattttaagc aaacacataa tcaatcctca ggtgcgttat taccacaagc 32280
aggacaaagt gccgtacgcg aagccgtact aacctggttt gacctacgta tggattcaag 32340
atggggtatt actcccccgg tggatgtggg tatgacacct cctatttgtg ttgatccacc 32400
ggctacaggg ttggaagctg tcatgataac agaagcacta aagattgcat atcctaccga 32460
atataatcgc tctagcgtgt ttgtggaacc gtcgtttgtg ccttatatta ttgcaacaag 32520
cacgcttgat gccctttcgg caacaatagc tttgtctttt gatacacggg gaatacagca 32580
agccttgtct attcttcagt gggctcgcga ttatggatcc ggaaccgtgc ccgatgcaga 32640
tggatatcgc acaaaactat ctgctcttat aacaatatta gaacctttta cccgtacaca 32700
ccccccagta cttttaccat ctcacgtttc tactatagat tcccttatat gcgaacttca 32760
tcggactgtt ggcattgccg ttgacctgct tccccagcac gtccgtcctt tggttcctga 32820
ccgtccttct attacaaata gcgttttttt agcaactctc tattatgatg aactttacgg 32880
tcgttggacc cgactggata aaacatcgca ggcgttggtt gaaaatttta catccaacgc 32940
gttagtggtt tctcggtaca tgttaatgtt acaaaaattt tttgcgtgtc gtttttatcc 33000
aacgccagat cttcaggctg ttggtatctg taacccaaag gttgaacgcg atgaacaatt 33060
tggggtatgg cgtttaaacg atcttgctga tgcggttggt catattgttg ggacaataca 33120
aggaatccga acgcaaatga gagtgggaat atccagcctg cgcacaatta tggccgatgc 33180
ttcctcagcc cttagggaat gtgaaaattt aatgactaaa acctccactt ctgctattgg 33240
gcctcttttt tcaacgatgg cttcccggta tgcacggttt acacaggatc aaatggacat 33300
tttaatgcgt gttgacaaac taacaacagg agaaaatata cccggtcttg caaatgtaga 33360
gattttttta aataggtggg aacgaatagc aacagcttgt aggcatgcca cggcagtccc 33420
gtcggccgaa tctattgcaa ccgtgtgtaa tgaattgagg cgcggtttaa aaaatataca 33480
agaggatcgt gtaaatgccc caacctcata tatgagtcac gcccgaaatc tggaagatca 33540
caaggcagca gtttcattcg ttatggactc caggcaacag tgtattgtgg attctggacc 33600
tcagatgggc gcggttttaa cttcacaatg taatatagga acatgggaga atgtaaatgc 33660
aacgttttta cacgacaacg ttaaaataac gacaacggtc agagacgtaa tttcagaggc 33720
tccgacgctg ataataggac aaagatggct tcgtccagat gagattttat ctaatgtaga 33780
tttgcgtctt ggcgtacccg ggaatacaag tgggagtgac ccttaatata aaacaggcgt 33840
gtttatgtac attaaagtat ttgtggtttt tattgactgg gcgtttcgtt tgtataacgc 33900
tgttgttgct agtattttca taacctccta ggtttttgga gctacacgtg cttattcaac 33960
gctctttggg atttgaatca tcgtaaacgt agcgtcccta ccagttgagc gcgtaatttt 34020
cgtaagcaat aaaatggata taattccgcc tatagctgtc actgttgcgg gagtgggaag 34080
ccgtaatcaa tttgacggtg ccctgggacc ggcgtcaggt ctgtcatgtt taagaacatc 34140
tttatcgttt ttgcatatga catatgcgca tggaattaat gcaaccctgt catcagacat 34200
gattgatgga tgtttacaag agggtgcagc atggactacg gatctgtcta atatggggag 34260
gggtgtccca gatatgtgtg ctcttgttga tctccccaat cgaatttcat atattaaact 34320
gggggacact accagtacgt gctgcgtttt gtctagaata tacggcgata gccatttttt 34380
taccgttcca gacgagggtt ttatgtgcac acaaattccc gctagagcgt ttttcgatga 34440
tgtgtggatg ggacgtgaag agtcgtatac aattataact gtagactcaa cgggaatggc 34500
catctatcgt cagggaaaca tatcttttat ttttgatcca catggccatg ggactatagg 34560
acaggctgta gttgttcggg tgaataccac ggatgtgtac tcttatatcg catcggagta 34620
tacccaccgc cccgataacg tagaatccca atgggccgct gcattagttt tttttgtcac 34680
cgcaaacgac ggtcccgtaa gcgaagaagc gctatcttcg gcagtaacgc ttatatacgg 34740
aagctgtgat acatatttta cagatgaaca atattgcgaa aaactggtta cagctcaaca 34800
tccgttgctt ctttcacctc ctaattccac gacaattgtg cttaataaat cgtctatagt 34860
acctcttcac caaaacgttg gtgaaagtgt atccttggaa gcaaccctac attcaacgtt 34920
aaccaacacg gttgcactgg accctagatg tagttacagc gaggttgatc cttggcatgc 34980
ggttctagaa acaacctcga ctgggtctgg cgttttggat tgtcgtcgta gacgccgtcc 35040
ttcatggact cctccttcaa gcgaggaaaa tttagcttgt atcgacgatg gcttggtgaa 35100
taatacacat tccacggata atttacataa acccgctaaa aaggttctca aatttaaacc 35160
aactgtagac gtgccggata aaacacaagt ggcacatgta ttaccccgcc tacgagaagt 35220
tgctaacacc ccagacgttg tgttaaatgt atccaatgta gatacgcctg aatccagtcc 35280
cactttttca cggaacatga atgtaggaag cagtttgaaa gatcggaagc catttctatt 35340
tgaacagagt ggtggtgtca acatggttgt cgaaaaacta ctacaacatg ggcatgaaat 35400
tagcaatgga tacgtacaaa atgcggtggg tacgttggat actgttatta ccggtcatac 35460
aaatgttccc atttgggtaa caaggccctt ggtcatgcca gacgaaaagg atccattgga 35520
gctttttatt aacctcacca ttttgcgttt aacgggattt gtggtggaaa atggaacacg 35580
tacacatcat ggtgctacaa gcgttgtatc agactttata ggtccccttg gggaaatttt 35640
aacaggattt ccctccgccg cggaacttat acgcgttaca agtttgatat taacaaacat 35700
gccgggggcg gaatatgcta ttaaaactgt tctccggaaa aaatgtacaa ttggcatgct 35760
cattatcgct aagtttggtc tagttgccat gcgggttcag gatacaaccg gcgctttaca 35820
tgccgaacta gatgtgttag aagcggatct aggaggttcg tcgcccatag acctctattc 35880
tagactgtcg acaggtctta taagtatact aaattcgcct attatttctc atcccggact 35940
ttttgccgag cttattccaa cccgtacagg gtccctgtct gaacgaatac gtcttctttg 36000
tgaattagtc tcggcccggg agacacgcta tatgcgtgaa cacaccgcgc ttgtttctag 36060
tgtaaaggct ttagagaatg cattacggtc tacccgcaat aaaattgatg ccattcaaat 36120
accagaagtt ccccaggaac ccccggaaga aaccgacatt ccacccgaag agttaattcg 36180
gcgtgtatat gagatacgat ccgaagttac aatgctattg acctcggctg ttacagaata 36240
cttcacccgc ggagtgttat atagcacacg ggccttgatc gctgaacaat cccctaggcg 36300
ttttcgggtc gcgaccgcaa gtacggcacc cattcaacgg cttttagatt ctcttccgga 36360
attcgacgct aaattaacgg caatcatatc gtccctgtct atacaccctc ctcctgagac 36420
tatacaaaat ctccccgtcg tatctctgtt aaaagagctt attaaagaag gggaagattt 36480
aaacacagac acggctctcg tatcgtggtt atctgtagtc ggggaagctc aaaccgcagg 36540
ttacttatcc agacgagagt tcgatgaatt atcacgtaca attaaaacca ttaatacacg 36600
cgcaacgcaa cgggcttccg cggaagcaga gttgtcttgc tttaatacgc taagcgcggc 36660
cgtagaccaa gccgtaaagg actatgaaac atataacaat ggtgaggtca agtatcctga 36720
aataacacgg gatgatttat tagcaacaat tgtacgtgct acagacgatt tggtgcgaca 36780
gataaaaatt ttaagtgatc caatgatcca atccggttta caaccttcga ttaaaagacg 36840
attggaaaca aggcttaaag aggttcagac gtatgcaaac gaggcccgaa ccacacagga 36900
cacaataaag agtcgaaaac aggcggcata taataaactc ggggggttac ttcgcccggt 36960
aaccggtttt gtgggactta gggctgcagt agatttatta ccggaacttg cttctgagtt 37020
agatgtccaa ggagccctgg taaatctcag gaccaaagtc ttagaggcgc cggtagagat 37080
ccgttctcaa cttacgggtg atttctgggc gttatttaac caatatcgag acattttaga 37140
acatcccgga aacgcacgca catctgtctt aggaggactg ggagcttgtt ttacagctat 37200
tatcgaaatt gtgccgatac ctacggagta tagaccatca ttgcttgcgt tttttggtga 37260
cgtggcagat gtgcttgcat ccgacatcgc gaccgtatct actaacccgg aaagtgagtc 37320
cgccataaac gctgttgttg caactcttag taaagcgacg ttagtttcat ctacagtgcc 37380
agccttatcc tttgtgttgt cgttatataa aaaatatcag gctttacaac aagaaattac 37440
gaatacccat aagttgactg aattacaaaa acaacttgga gatgacttct ccaccctagc 37500
tgtctcatct ggacacttga agtttatatc atcttcaaat gtagatgatt atgaaataaa 37560
cgatgcgata ttatcaatac aaacaaatgt gcacgccctg atggatacgg ttaaacttgt 37620
tgaagttgaa ctgcaaaagc taccccccca ttgtattgct gggacatcta ccttatctcg 37680
agtagtaaag gatcttcata aactcgtcac aatggcacat gagaagaagg aacaggcaaa 37740
agtgttaatt accgattgtg aacgtgcaca taaacaacaa acgactcggg ttttgtatga 37800
gcgttggaca cgtgatatta tagcatgtct ggaggcaatg gaaacgcgcc atgtatttaa 37860
cgggacagaa ctggcacggt tgcgagatat ggccgctgcg ggagggtttg atatacacgc 37920
agtttaccca caagcacgtc aggttgtagc ggcatgtgaa actacagccg ttacggcatt 37980
agatacygtg tttcgccaca atccacatac ccccgaaaat acaaatattc ccccaccttt 38040
ggctttgtta agagggttaa catggtttga tgatttttcg attacggctc ccgtattcac 38100
cgttatgttt ccaggtgtta gtattgaagg actccttctg cttatgcgta ttcgcgcggt 38160
tgtgttatta tccgccgata cgtctattaa tggaatacct aactaccgag atatgatatt 38220
acgaacctcg ggggatctat tacaaatacc cgcattggct gggtatgttg atttttacac 38280
acggtcttat gatcagttta taaccgaaag tgtaacgtta agtgaactta gagcagacat 38340
cagacaggct gccggggcta aacttacaga agcaaataag gctttggagg aagtaactca 38400
tgttcgggca cacgaaacgg ctaaacttgc acttaaagaa ggtgtcttca ttacattacc 38460
aagcgaaggt ttattgattc gggctataga gtattttaca actttcgatc ataaacgatt 38520
tataggaacg gcatatgaaa gagttttaca aacaatggta gaccgcgatc taaaggaggc 38580
caacgcagag cttgcacagt ttcgtatggt gtgtcaggca acaaagaacc gtgcaataca 38640
aattttacaa aacattgttg atactgctaa tgccactgag caacaagaag acgtggattt 38700
cactaacctg aagacgttat taaaactaac cccccctccc aaaacaattg cattggccat 38760
tgatagatct acttccgttc aggacattgt cacgcagttt gcattgctgt tagggcgtct 38820
ggaagaagaa actggtacgt tggacattca ggcggttgac tggatgtacc aagctcgcaa 38880
tattattgac tcccatccac taagtgtgcg tatagacggt accggccccc tgcatactta 38940
taaagatagg gtggataaac tttatgcgtt acggactaaa ttagatctcc tacgacgacg 39000
aatagaaacc ggtgaggtta cgtgggacga tgcatggaca acatttaaaa gagaaacggg 39060
ggatatgttg gcatcggggg acacgtacgc tacttccgta gatagtataa aggcactcca 39120
ggcatcggcg tctgtggttg acatgctttg ttccgaaccc gaattttttt tattgcckgt 39180
ggaaacgaaa aaccgtctcc aaaaaaagca acaagaacgt aaaacggcgt tggatgttgt 39240
gttgcaaaaa caaagacagt ttgaagagac cgcgtctcgc ttacgagctt taattgaacg 39300
tattccaacg gagagtgacc atgacgttct tcgtatgtta ttacatgatt tcgatcaatt 39360
tacacatttg cctatatgga taaaaacaca gtatatgaca tttcgaaatt tactcatggt 39420
acggttaggc ttgtatgcaa gttatgctga gatttttcca cccgcgtctc caaacggagt 39480
gtttgctcct attcccgcca tgtcgggtgt atgtctagaa gaccaatccc gatgcattcg 39540
cgcgcgggtg gccgcgttta tgggggaggc gtctgtggtg caaacgttta gggaagccag 39600
atcttctata gacgctttgt ttggaaaaaa tttaaccttt tacttggata ctgatggggt 39660
tccacttcga tatagagtgt gttataaatc agttggggtt aaacttggaa ccatgctatg 39720
cagtcagggt ggattatctt tacgaccggc acttcccgat gaaggtattg tggaagaaac 39780
tacactatcg gcattacgcg tggccaatga ggtcaatgag ctacgcattg aatacgaatc 39840
cgctataaaa tccgggtttt ctgccttttc cacctttgtt aggcatcgcc acgccgaatg 39900
gggtaaaacc aacgcacgca gagccattgc agagatatac gccggcctta taacaacaac 39960
attgacacga caatacgggg ttcattggga caagcttatt tattcttttg aaaaacacca 40020
cctaacttct gtaatgggca atggactaac taaaccaatc cagagaaggg gtgatgtacg 40080
cgtattagag ttaaccctat ctgatattgt aactattttg gttgccacaa ccccggtaca 40140
tcttctcaat tttgctagat tggatttaat taaacagcat gagtatatgg cccgtaccct 40200
cagacccgta atcgaggccg catttagagg tcgtttactc gttcgctcat tggatggaga 40260
cccgaaaggc aatgcccggg ccttttttaa tgccgcccca tccaaacata aactcccgtt 40320
agctcttgga tcaaaccagg atcctaccgg cgggagaata tttgcatttc ggatggcaga 40380
ttggaaactt gttaaaatgc cacagaaaat aacggatcct tttgcgccat ggcaactttc 40440
cccccccccc ggggtaaagg ccaatgtcga tgcagttacc cgtataatgg caacagatcg 40500
tcttgcgacc attactgtac ttgggcgcat gtgtctcccg ccaatttcct tagtgtcaat 40560
gtggaatacg ctgcaaccgg aggaattcgc atacagaaca caagatgatg tggacattat 40620
agttgatgcg agactggatt tgtcatccac gcttaatgca agatttgata ccgctcccag 40680
caataccacg ttagagtgga atacagaccg taaagtaatt acagatgctt atattcaaac 40740
cggggcaacg acagttttta cagtaacggg ggcggcacca actcacgttt ctaatgtaac 40800
agcgtttgac atagcaacta cggctatttt atttggggct cctttggtta ttgccatgga 40860
acttacatcc gttttttcac aaaattccgg acttactttg gggttaaaat tattcgattc 40920
ccggcatatg gctacagatt cgggtatatc ctcagccgta tctcccgata ttgtttcttg 40980
ggggttacgt ttactgcata tggatcccca cccaattgaa aatgcatgtt taattgtcca 41040
actagaaaaa ctgtccgcgc tcattgcaaa caaacctctt acaaacaatc ccccgtgttt 41100
actgctattg gacgaacata tgaatccctc ttatgtttta tgggaacgaa aagactcgat 41160
tccagctccg gattatgtgg tcttttgggg gccagaatct cttattgatt tgccgtacat 41220
cgactccgat gaggactctt tcccctcgtg tcccgatgat ccattttact cgcaaattat 41280
tgccggttat gcgccccaag gccccccaaa cctcgacaca actgattttt acccaacgga 41340
gccactattt aagtctcccg ttcaagttgt tagaagttcc aaatgtaaaa aaatgcccgt 41400
ccagcccgtc cagcccgtcc agcccgcgca gcccgtccag cccgcgcagc ccgcgcagcc 41460
cgtccagccc gcgcagcccg tccagcccgc gcagcccata gaaccgggca cacaaatagt 41520
ggtacaaaat tttaagaaac cccaaagcgt aaaaacaacc cttagccaaa aagatattcc 41580
cttgtatgtg gaaactgaat cagaaacggc tgtgcttata cctaagcaat taaccacctc 41640
cattaaaaca accgtttgta aaagtattac cccaccaaat aaccaattgt cggattggaa 41700
aaataatcca cagcaaaacc aaacgttaaa ccaagcgttc aataaaccaa tacttgagat 41760
tacctccatt ccgacagatg actcgatatc ttaccggact tggattgaaa aatcaaatca 41820
aacacaaaaa cggcatcaaa atgaccctcg aatgtataac tccaaaacag tattccaccc 41880
tgtaaataac caattacctt cttgggttga cacggcagcc gatgcccccc aaacggacct 41940
attgacaaac tataaaacaa gacagccgtc gccaaacttt ccgcgggacg tacacacatg 42000
gggcgtatct tctaacccgt ttaactcacc gaacagagac ctatatgaaa gtgattttag 42060
tgaaccttct gacggctata gcagtgagag tgaaaattct atcgtactaa gtctcgacga 42120
acatcggtca tgtcgcgttc ctaggcacgt acgtgttgtt aatgccgatg tagtcaccgg 42180
tcgacgttat gtccgaggga ccgccttggg agcactggcc ctgttaagcc aggcatgtcg 42240
gcgtatgatc gacaacgtta gatatacacg taaactttta atggaccaca cggaagatat 42300
atttcaaggc ctggggtatg ttaaattgtt attagatgga acatatatat aaagtagcgc 42360
ctattaaaga aaaaaaaaca acgattattt tctgtgtatt tttatttaca ccctacgact 42420
tcttgaagcg tttccagatt gtcccgtgtg ggacaaggtc tgtcccttac ccccctgggg 42480
ggtattttgg gttgggggcg gggtagactg tggcacgcct tgggccgcgg gcggtgatcc 42540
ggttgttggc tggacagtgc ttgactgtgc tccctgttgc ggttgttgtc cagaagaccc 42600
cgacaccacg tgttgctgtt gtccaacgga tgccgacgtc gtttgaggtg gggggtgttg 42660
cggggatgat cccgaaaacg ccaacgcggc gggctgttgt aaagcagact gatcggcgct 42720
ctgtgttttt tgcggcaata tagtaggccc cgagattccc aaactcatgg atggatttgg 42780
gggttgtggt cgtataatac gcgggttaaa cgtacgtttt aagccaaccg ttggtcttaa 42840
ccatgtcata gggtcagtct cggcaaacat ggccgttcgg cgtatcgtat ttgcattatg 42900
gttagcgcgt gcacgcgcgg cactggccgc ggctcccacg gtgtaaatgc ttctggcatc 42960
agcgatgtcc acacggtgac caggttgcaa aggtccactg gcgtttaaaa gtcgtattaa 43020
agcaacgggg gtgtaagccg caattgcttc caccgaaaat gtggtggggt tgctgggatc 43080
aaagactaca cgagacgatg cgggttgtgt catcgtttat tagtttacgg gacaatcgat 43140
aacagcatac acgtacatct gcgcaggata tgtacggaaa ggcaatttat ttccagaaaa 43200
gcaccgcccc taatacaact accagtacaa ttacaacgaa cagggcatat gtcacgttag 43260
ctacgggtag agcaagtttc cagacacgcg tagtttgggt atcgggtaac gcaggtttaa 43320
tgtcactttg catttgaaca gacgtgtttg gacttccgtt ctcgggtggg gatctgaatg 43380
aaggccgcca gcgtatatat tcatccaaat tattgccagt ttccttatac atgtatgcat 43440
ccgtggcgcg ggccataagt ttaatggtgc gagatggatc ttccggtccc ataaaacgaa 43500
aggataactg aacatatggc attcgcacaa agcagttcac ccacattaaa gcctggagag 43560
gtcggcggtc aataccccca cctcgtttaa ttgattccaa agcagatagg ttgataccgg 43620
tacttaacgt tgaactaaga atcacgttat tactgtcaat ggacacttca gccactggtg 43680
cgttagtcgg acgaaaaaaa aaaccttgaa atagcacaga cacccccgta ttttgaattt 43740
ttatgtaagg gtcacaatct acttgcgccc aattcgccat taaacgcata atatactcta 43800
ccggaaaggc ttcggatacg ttgtcttcgc cgttaaactg aaaaacacaa cgggcggggg 43860
ggcgttgtgg atcaaatatt ggaagatccc catcgcaaca ttgaagagcg cttggtacca 43920
ccaaccgaat acgttgtaaa agattatctc cgcaacccct cctgcgttca ctccgtacat 43980
acgttctccg tgacatattg atctaaggtt gcaaaccaag gcacacgcgt gaagtattta 44040
gaccatttat cgtgggatat aggaggagtt tggagtgatc caccccctga cgacttatta 44100
atgcgtttat tttccccatg tattaagcat ccttcaatat ttcatgcaaa tctagaaatt 44160
tggccatgac tcccgcaaag cgttcacggc gacgggtcac gctggcacta tgttcacatg 44220
gaacaacata agcagatttt tctgaatcgt tactttcttt atgttttaaa acggacgcca 44280
ggcgactggt aaatgatata taatttaatt gagcgtcagt tgtaggtaga attgcttcta 44340
tttccggggg aattaaattt tcaaaccaaa cggaaagagt aaaggtgcta tcagcaggaa 44400
aatactttga ctccagtgca tcgatattta atagattaac atcggtgtct gtaattaaat 44460
cgcgggccct catcccagag atggatcggg tagaatcaga agaacccatg gatggattcg 44520
aatcgcccgt attctccgaa aatacatctt ctaattccgg atggtgttcc gacgcatttt 44580
ccgattcgta catcgcttat aatccagccc ttctgctaaa aaacgatttg ttattttcag 44640
aattgttatt tgcctcccac ttaataaatg ttccccgtgc aatagaaaac aacgtcactt 44700
atgaggcctc ttcggcggta ggtgtggata atgaaatgac ctcaagtacc actgaattta 44760
tagaagaaat tggagacgtt ttggcgttag acagagcctg tttggtctgt agaacgcttg 44820
atttgtataa acgtaaattt ggactgacac cggaatgggt tgcggactac gccatgttat 44880
gtatgaaaag tctggcatcc ccgccctgtg cagttgtcac ttttagcgct gcctttgaat 44940
ttgtgtatct tatggatcgt tactacctgt gccgttataa cgttactttg gttgggtcct 45000
ttgccaggcg cacgctttcc ctgttagata tacaaagaca tttttttttg catgtatgtt 45060
ttcgtaccga tggagggtta ccaggtatac gaccgccccc cggtaaggaa atggccaaca 45120
aagtaagata ttccaattac tccttttttg tacaggcggt agttagggct gcattactat 45180
cgatcagcac gtctcgttta gacgaaaccg aaacgcgtaa gtcattttac tttaatcagg 45240
acggactgac tggaggccct caacctttag cggccgcctt ggctaattgg aaagattgcg 45300
cgcggatggt tgactgttca tcatcggaac atcgcacaag tgggatgatt acctgcgcgg 45360
aacgtgcatt aaaagaggat atagagtttg aagatatatt aatagacaaa cttaaaaaat 45420
cgtcttacgt agaagcagct tggggttacg cagacttggc tttattatta ctgagtgggg 45480
ttgctacttg gaatgtagac gagcgtacaa attgtgctat agaaactcgc gttggatgtg 45540
ttaaatcata ctggcaggcg aaccggattg aaaactccag ggacgttcca aaacaatttt 45600
ccaaatttac gagcgaggat gcctgtcccg aagtagcatt tgggcctatt ttgttaacta 45660
ccttaaaaaa cgcaaagtgc cgtggtcgca cgaataccga atgcatgtta tgttgtttat 45720
taaccatagg gcactattgg atcgctttgc ggcagtttaa aagggatata ttagcatact 45780
cagcaaataa cacaagttta tttgactgta tcgaacctgt aatcaatgca tggagcctag 45840
ataaccccat taaacttaaa tttccattta atgatgaggg tcgattcata accattgtaa 45900
aagcagcagg ttccgaggcc gtatataaac atttattttg cgatctccta tgcgctctct 45960
cggaattaca gacaaaccct aaaattttat ttgcccatcc tacaaccgcg gataaggaag 46020
tgttggagtt atataaagcc caactggctg cacaaaacag atttgaaggt cgtgtatgtg 46080
ctggcctgtg gacattggcg tatgcattta aagcctacca gatttttcca cgcaaaccaa 46140
ccgccaatgc cgcattcata cgagatggag gacttatgct tcgacgacat gcaatatcgc 46200
tggtctccct cgaacacacc ctatcgaagt atgtctaggc gatataaatc cgtatctcgg 46260
agcgggcctt cgatgcgtgt acgctccaga acgccatgcc gccgtcaaac cattcgagga 46320
aaacttatgt caaaggagcg gtctgtgtac cgccattatt ttaattacat cgcaaggtcc 46380
cccccagaag aactagctac cgttagaggc ttaatcgtgc caattattaa gacgacccct 46440
gtcacccttc cgtttaactt gggtcagaca gtggcggata actgcctgtc gttatccgga 46500
atgggttatc atttaggtct cggaggttat tgtccgacat gcactgcatc tggagaaccg 46560
cgtctatgtc gaaccgatcg ggcggctctg atactagcat atgttcagca gcttaacaac 46620
atatacgaat atcgtgtgtt tcttgcatcc attttggcgc tatcagaccg agccaacatg 46680
caagcagcgt ccgctgaacc cctattgtcg agcgtattgg cacaaccgga attatttttt 46740
atgtatcata ttatgaggga ggggggcatg cgagatatac gcgtactttt ttatcgtgat 46800
ggagatgccg gagggtttat gatgtatgtt atatttccgg ggaaatctgt tcacctccat 46860
tacagactaa tcgatcatat acaggccgcg tgtcgggggt ataaaatagt cgcacacgtt 46920
tggcagacaa catttttact gtcggtatgt cgcaacccag aacaacaaac agagactgtg 46980
gtgccatcca ttggaacatc ggacgtttac tgtaaaatgt gtgaccttaa ctttgatgga 47040
gaattgcttt tggaatacaa aagactctac gcattatttg atgactttgt tcctcctcgg 47100
tgatttcagc ttcagtgttc attttattat cccagcgcgg ggcgtgtata caaacaaagc 47160
ctgccgcctg caagcggttt agcattttaa cgttaacaac tcgtgtctct ggaataaaac 47220
gttttaaaag ccgttctgtg agtttagtgt cgtttccaaa taacgcctta aaagttacac 47280
tcgccgtccc aatgagatga gaaaaataat agtcaatgtt taaagacagc ccgtgtgatg 47340
ttacgtgaat gggatcttcc gctaagtcag atattattaa cttacgcttt gcttccccac 47400
accgtttacc tgcggtattc tgtaaaggat ctccacgtag caaagctaca ctttttgcat 47460
cagcctccac ttcgtctgtg ggggccacaa taacataagg gatgcgttct cgaacgtttg 47520
ggatttgacc ctgtctcatt actaatttat aatatactgt taagtgagcc aagcgacggt 47580
ttatgtaggc ggatggtgga cgactaagct cggccgtcat aacaaactta ttaatatcca 47640
atttgggtga tgtaatctgg cgatgtgcat ctgcaattat gcgtccaaac ccggccatcc 47700
cagacggcat ggcccgtcta ttccattcag caatggaaac acacgacgcc tccgccgcag 47760
cacgcgagac ggtgtcgtca tataacaaca gttctacaag tttgcgggca taatcgttaa 47820
taaattgaca gttgtttttt ctaaccaagt cgactccctt cattaaaacc tttccgccgt 47880
aaattacccc aatgtacttt ttctttgtta taagtaaaag ttttataaaa gttttttcac 47940
actccaactt tataggagga caaaacagag ccgttgaaat tatatgtgcc attttctcgc 48000
cgattttagc tatcccctca acaccaacac ccttgaatcg gataaacaca gaatccgtat 48060
ctccatatat aacctttacc tcgtacgctt tttgggagag aacgctactt tcaatgtctg 48120
gaaacgctgt aataaaacgt tcaaatgcgg cccagttatt atgaatataa tctctggtac 48180
ttaataacat ttgacggcca attgtagtga cagtggccgc tacgtataaa catggcagaa 48240
atccctgcgc aactccagta aaaccgtaca cggaattaca aactactttt atcgcggctt 48300
gttgtttgtc taataacact gcttcatctg aagaacttcc gggtatgcgc gctctaatag 48360
ccttgcgcat agccaaccag tcttttaaaa gaacacccag cagactttct cgaacgttag 48420
agcgcacaaa aaaaagacgt tttcctccaa ctgtaaaggt ggcataatcg gatggattca 48480
aacgtttaac cgtctcaaaa tttaacgtta gcgtggtaaa acataagtta tgggcctgaa 48540
ttatacttgg atataaactt gcaaaatcca atacgaccac cggatcgata taaaatcccg 48600
tatcagggtc aaaaaccctg gctcctttat atcctacatt tcgcccactt gacgtaccag 48660
tgggagaaac gctctcgtct tcatccatct cttcctcaac atccccgaca tcgggaataa 48720
catccttata ttcaaaagta gctgggtatc ccccatcggg taaaataaat cctcgagacg 48780
aagccagtcc taataaacaa gtgtaaatcc taacctgctg tccgtcgtaa atagccttgg 48840
ttaaagtaat tctagctagc cttgcaaccg cggataactc aaggtgtggt aaatatttaa 48900
aaaacagttt ccccacaaga gccgagtctt gtatacaata ttcaccaata attcctcgtg 48960
tattcggtcc actagcgtaa tatcccggaa tgtctttgta gggcaaatct ctcttggact 49020
catttagagc ttcacgtgca accgaatcta atttataact cgagagtttt aatttttcag 49080
ttgcaattgc atacatatcc agagatatga gaccgttgat ctttaccttg cttcgtcgct 49140
gaaatccgga tttgccaaca tcccatatct taaacagacc cccacggttt atactgccat 49200
aaccatcaag cttgagactg tatatagaat taagtttctc cataataaac gcccaatcaa 49260
aattaacaat gttataacct gtggcaaact cgggagcgta ctgttttacg agggtcataa 49320
atgcaattaa tagctcgaat tcactatcaa actccagcac agtcggctcc ggtaaccccg 49380
cgtccttcat ttcttgtaca tacctttgtg gtaagtcaca agagccaagg gaaaacagta 49440
aaatgtgttc taaagactgt cgagggattg aatataatag acaagaaatt tggattacaa 49500
gatcctccaa atgtgttgca tcgggaaacg ccagctcatt agatcctcct gatttacatt 49560
caatatcgaa acataacaac ttgtagtcag gccatgagtc atcgtttggt atagcctgca 49620
gattatccga catgcagtca atttcaacgt cgcttaacgt taattggcga cttgccggtc 49680
gaactcgaac acgttcccca tcaactccag gttttagttg ataccaacca aaactaacaa 49740
agccgggatt atccattaga aaacgagtgg tagcgtctac ccgaccttca tactttttca 49800
actccgggtg aaagttatca caaagataat ttgtaaattt agatgaggga gaatacaccc 49860
tgtaaaacgc acatggctgt gtatcgtagt aataaacatc tgtgcgctca ataacctcaa 49920
cgcgaaagct ttctggagat gcgcttttaa acgaggtacc atgaaaagcg ttcttgtctc 49980
catttaacgt tgcatcattt tgtgttatca tagaactgcg taaacactcg gcaagtaata 50040
cagataactc gctacaggaa cgtatgccac aagcggtatc cacctcggct ttgtttatat 50100
aaaaatattg acagatgccg tatacatgaa ctgccaccct ttttccacat cgggacatgc 50160
caagtaaagt aataacggta ccaagcggtc gtgttgcagt tgcaaaccgg gatacatctc 50220
cattagacgc ggcttctgtt gtttcgacaa tatcatatac atggaatgtg ttaaagcggg 50280
ggtcaaactt atccccacga aagtcgattt ccccccaaat attcacgcgt ctaggccagg 50340
ggctggaaca acgaaaatcc agaatcggaa cttcttttcc attacagtaa actttaggcg 50400
gtcgactaag tgtaccgacg tgaaccccct ttcgttcttc catgggcaca tcttcatcta 50460
aacatttagg ggccaaaaat tgaaacgatg acatggtagt tttgtaacta tgaagaaatt 50520
ctctgttact accgcgcccg gttcttgggt tatatttaat ccctgatgct tgggttaaaa 50580
agggattaca aaaccccgtt ctgatcgcca ttttatgtta acgattgata atcttgtaaa 50640
aagccagtgt tactgagtaa cacaacccca cgcccttcta atacataaag tgtaatcacg 50700
tgatttgttg tggtttccgc atatgtaata cccgtttaaa agcctctctt cttaatgtat 50760
cgacagactg ggttttgggt ggtcatttga ccctgccaac aaccccccat tattacgagt 50820
acttcaccaa aatggaaaat actcagaaga ctgtgacagt gcccacgggg cccctgggtt 50880
acgtttatgc gtgccgggtt gaagatttgg atctggagga aatttcattt ttggccgctc 50940
gtagcacgga ctctgatttg gctttattac ctttgatgcg taatttgacc gtggaaaaaa 51000
cttttacatc cagcctggcg gtggtttctg gagcacgcac tacgggtctt gccggagctg 51060
gtattacctt aaaactcact accagtcatt tctatccatc tgtctttgtc tttcacggag 51120
gcaaacacgt tttacccagc tctgcggccc caaatctcac acgcgcgtgt aacgcggctc 51180
gagaacggtt tgggttttca cgctgccaag ggcctcctgt tgacggtgct gttgagacga 51240
ccggcgctga gatatgcacc cgccttggat tagagccaga aaatacaata ttatacttgg 51300
tggtcacggc attgtttaag gaagccgtat ttatgtgcaa cgtgtttctg cattatggag 51360
gactcgatat tgttcatatt aaccatgggg atgttatacg tataccgtta tttccggtac 51420
aacttttcat gcccgatgtt aaccgtctgg tacccgaccc attcaacact catcacaggt 51480
ctatcggaga gggttttgta tacccaacac ccttttataa caccgggttg tgccatttaa 51540
tacatgactg tgttattgct cccatggccg ttgccttgcg cgtcagaaat gtaactgccg 51600
tcgcccgagg agcggcccac cttgcttttg atgaaaatca cgagggggca gtactccccc 51660
ctgacattac gtacacgtat tttcagtcct cttcaagtgg aaccactacc gcccgtggag 51720
cgcgtcgaaa cgatgtcaac tccacgtcta agcctagccc atcggggggg tttgaaagac 51780
ggttggcgtc tattatggcc gctgacacag ccttgcacgc agaagttata ttcaacactg 51840
gaatttacga agaaactcca acagatatca aagaatggcc aatgtttata ggcatggagg 51900
gcactttgcc aaggctaaac gctctggggt catataccgc tcgtgtggcc ggggtcattg 51960
gtgcgatggt tttcagccca aattctgcgt tgtatctaac tgaggtggag gatagcggga 52020
tgaccgaagc caaggatggg ggaccgggtc catcatttaa tcgattttac cagtttgccg 52080
gacctcattt agctgcgaat ccccaaacag atcgagatgg ccacgttcta tccagtcagt 52140
ctacgggttc atcaaacaca gagtttagcg tggattattt ggcactcatt tgtggatttg 52200
gagcacccct gttggcgcga ctgctttttt atctagaacg ctgtgacgct ggtgcgttta 52260
cagggggtca cggggatgcg ttaaaatatg ttacggggac ctttgactct gaaattccat 52320
gtagtttatg tgaaaaacac acgcggccgg tatgcgctca cacaacagta caccgactta 52380
gacaacgcat gccgcgattt ggacaagcca cccgtcaacc tattggggtg tttggaacaa 52440
tgaacagcca atatagcgac tgcgatcctc taggaaacta tgctccatat ttaatccttc 52500
gaaaacccgg ggatcaaacg gaagcagcaa aggcaaccat gcaggacact tatagggcta 52560
cactagaacg cttgtttatc gatctagaac aagagcgact actggatcgc ggtgccccat 52620
gttcttccga gggactatcg tctgtcattg tggatcatcc aacgtttcgt cgcatattag 52680
acacactgcg tgcgcgtata gaacagacaa caacacaatt tatgaaagtg ttggttgaga 52740
cccgcgatta taagatccgt gaaggattat ccgaagccac ccattcaatggcgttaacgt 52800
ttgatccata ctcaggagca ttttgtccca ttaccaattt tttagttaaa cgaacacacc 52860
tagccgtggt acaagactta gcattaagcc agtgtcattg tgtattttac ggacagcaag 52920
ttgaggggcg gaactttcgt aaccaattcc aacctgtttt gcggcggcgt tttgttgacc 52980
tgtttaatgg ggggtttata tcaacacgct ctataaccgt aacattatct gaaggtcctg 53040
tatccgcccc aaatccgaca ttgggacaag acgcgcccgc ggggcgtacc tttgatgggg 53100
atttagcgcg cgtaagcgtg gaagttattc gggatatacg agttaaaaat agggtcgttt 53160
tttcaggtaa ctgtacaaat ctctctgagg cagcccgggc aaggcttgta ggccttgcaa 53220
gtgcgtacca acgccaagaa aaaagagtgg atatgttaca cggggcccta gggtttttgc 53280
ttaaacagtt tcacggcctg ttatttcctc ggggtatgcc accaaacagt aaatccccca 53340
acccgcagtg gttttggacc ctgttacaac gcaaccagat gccggcagat aaacttacac 53400
acgaagagat taccactatt gcagctgtta aacggtttac cgaggaatat gcagcactaa 53460
actttattaa tctaccccca acctgcatag gagaattagc ccagttttat atggcaaatc 53520
ttattcttaa atactgcgat cattcacagt accttataaa taccttaact tctataatta 53580
cgggtgccag gcgcccgcgt gacccatcat ccgttttgca ttggattcgt aaagatgtca 53640
cgtccgccgc ggacatagaa acccaagcaa aggcgcttct tgaaaaaacg gaaaacttac 53700
cggaattatg gactacggct tttacttcaa ctcatttagt ccgcgcggcc atgaatcaac 53760
gtcccatggt cgttttagga ataagcatta gtaaatatca cggagcggca ggaaacaacc 53820
gcgtctttca ggcagggaat tggagcggtt taaacggggg taaaaatgta tgcccgctat 53880
ttacatttga tcgcactcgc cgttttataa taacatgtcc tagaggaggt tttatctgcc 53940
ccgtaacagg tccctcgtcg ggaaatcgag aaaccaccct atccgaccaa gttcgcggta 54000
taattgtcag tggcggggcc atggttcaat tagccatata cgccacggtt gtgcgtgcag 54060
tgggcgctcg agcacaacat atggcatttg acgactggtt aagtcttaca gacgatgagt 54120
ttttagccag agacttggag gagttacacg accagattat ccaaaccctg gaaacgccct 54180
ggaccgtaga aggcgctcta gaagcagtaa agattctaga tgaaaaaacg acagcgggag 54240
atggggaaac ccccacaaac ctagcattta attttgattc ttgtgaacca agccatgaca 54300
ccacatctaa cgtattaaac atttcagggt caactgtccc tggtcttaaa cgaccccccg 54360
aagatgacga actctttgat cttagtggta ttcccataaa acatgggaac attacaatgg 54420
aaatgattta acctccctct ttatccaatt aaagcccaca cgcgggtgag tgtacgtaat 54480
aaacaagtca atattacata ttctgttgtg ttttcttttt tgcgtgtagt ccttacccat 54540
atgacctgta atatagtgtg tctccaacca ttcagcttac agtccagtgg acagtaacag 54600
cccgataaca tggaattgga tattaatcga acattgttgg ttctactggg tcaagtttat 54660
acgtacatct ttcaggttga actgctacgt cgatgtgatc caagggtggc gtgtcgcttt 54720
ttatatcggt tagcggctaa ctgtttgaca gttcgttatt tattaaagct gtttctccgg 54780
ggatttaata cccagctaaa atttggaaac actcccacgg tttgtgcact gcattgggca 54840
ttatgttatg taaagggaga aggtgagcgt ttgtttgagt tgctacaaca ttttaaaacg 54900
cgttttgttt atggtgagac taaagactca aactgtatca aagattactt tgtctcagcg 54960
tttaacttaa aaacctgcca atatcaccat gagctgtcgt taacaacata cggaggttac 55020
gtatcgagtg aaattcagtt tttacacgac attgagaatt ttttaaaaca gcttaattac 55080
tgctatatta tcacgtcttc tcgtgaggcg ctaaacacat tggaaaccgt gacgcggttt 55140
atgacagata ctataggaag cggtctaata ccacccgtgg agttgtttga tccggcgcat 55200
ccatgtgcta tatgttttga agaattatgt ataacagcta accaaggtga gaccttacat 55260
cgtagattat taggatgtat ctgcgatcac gttactaagc aagttcgggt taacgtggat 55320
gttgacgata ttattcggtg tttaccatat atccctgatg taccggatat caaacgtcaa 55380
tccgccgttg aagcgttacg aacacttcaa accaagacgg tagtcaatcc catgggagca 55440
aagaacgata cgtttgacca aacatacgaa attgcgagca ccatgcttga ttcttataat 55500
gtttttaaac ctgcccctcg gtgtatgtac gccatcagcg agcttaaatt ctggttaacg 55560
tctaattcca ctgaaggacc ccaacgtact ttagacgtgt ttgttgataa tttggatgta 55620
ttaaacgaac atgaaaaaca cgcagaactt acagccgtaa cggttgagtt ggcgttattt 55680
ggaaaaactc ccatacactt tgatagggcg ttttctgaag aactcggatc tctggatgca 55740
attgatagta ttttggttgg caatcgctca tcctcaccgg acagtcagat agaagcatta 55800
attaaagcct gttatgccca tcatctatcg tcgcctctca tgcgtcacat ttctaacccg 55860
agtcatgata acgaagccgc cttacgccaa cttttagaaa gagttgggtg tgaggatgat 55920
ttaaccaaag aggcgagtga cagcgctaca gcatccgaat gtgatctgaa cgatgatagt 55980
agcataactt ttgctgttca tggatgggaa aacctgttat ccaaagcaaa aattgacgct 56040
gcggaaagaa aacgagtata tcttgaacat ctgtctaagc gctctctaac cagcctcggt 56100
agatgtatcc gcgaacagcg ccaagagcta gaaaaaacac tcagggtaaa cgtttatgga 56160
gaggccttat tgcagacatt tgtttcgatg caaaatgggt ttggggcacg aaacgtgttt 56220
ttagctaagg tttcccaggc agggtgtatt atcgacaatc gcattcagga agcggccttt 56280
gatgcacata gatttataag gaatacctta gttcgacata cagtagatgc ggctatgtta 56340
cctgcactta cacataaatt ttttgagttg gtcaacggcc cattgtttaa tcacgatgaa 56400
caccgttttg cacaaccccc taacaccgcc ttatttttta ccgtggaaaa cgttggccta 56460
tttccgcact taaaagagga attggcaaag tttatgggcg gtgtcgttgg ttccaactgg 56520
cttctcagtc catttagggg cttttattgc ttttctgggg tagaaggcgt tacttttgca 56580
cagagacttg cctggaaata tattagggag cttgtgtttg caaccacact attcacctct 56640
gttttccatt gtggggaggt gcggttatgt cgcgttgacc gtctaggtaa ggatccacgc 56700
gggtgcacgt ctcaacctaa aggtataggc agttcccacg gacccttaga cggcatttat 56760
ttaacgtacg aagaaacatg tccccttgtg gctattattc aaagtggaga aacagggatc 56820
gaccagaata ccgtcgtaat ctacgattca gacgtttttt ctcttctata caccctaatg 56880
cagcggctgg ctccggattc aacggacccg gcgttttcat aacctccgtt acgggggtgt 56940
ggttatgctt tttatgcata ttttctatgt ttgttacggc ggttgtgtcg gtctctccaa 57000
gctcgtttta tgagagttta caagtagagc ccacacaatc agaagatata acccggtctg 57060
ctcatctggg cgatggtgat gaaatcagag aagctataca caagtcccag gacgccgaaa 57120
caaaacccac gttttacgtc tgcccaccgc caacaggctc cacaatcgta cgattagaac 57180
cacctcggac atgtccggat tatcaccttg gtaaaaactt tacagagggt attgctgttg 57240
tttataaaga aaacattgcc gcgtacaagt ttaaggcgac ggtatattac aaagatgtta 57300
tcgttagcac ggcgtgggcc ggaagttctt atacgcaaat tactaataga tatgctgata 57360
gggtaccaat tcccgtttca gagatcacgg acaccattga taagtttggc aagtgttctt 57420
ctaaagcaac gtacgtacga aataaccaca aagttgaagc ctttaatgag gataaaaatc 57480
cacaggatat gcctctaatc gcatcaaaat ataattctgt gggatccaaa gcatggcata 57540
ctaccaatga cacgtacatg gttgccggaa cccccggaac atataggacg ggcacgtcgg 57600
tgaattgcat cattgaggaa gttgaagcca gatcaatatt cccttatgat agttttggac 57660
tttccacggg agatataata tacatgtccc cgttttttgg cctacgggat ggtgcataca 57720
gagaacattc caattatgca atggatcgtt ttcaccagtt tgagggttat agacaaaggg 57780
atcttgacac tagagcatta ctggaacctg cagcgcggaa ctttttagtc acgcctcatt 57840
taacggttgg ttggaactgg aagccaaaac gaacggaagt ttgttcgctt gtcaagtggc 57900
gtgaggttga agacgtagtt cgcgatgagt atgcacacaa ttttcgcttt acaatgaaaa 57960
cactttctac cacgtttata agtgaaacaa acgagtttaa tcttaaccaa atccatctca 58020
gtcaatgtgt aaaggaggaa gcccgggcta ttattaaccg gatctataca accagataca 58080
actcatctca tgttagaacc ggggatatcc agacctacct tgccagaggg gggtttgttg 58140
tggtgtttca acccctgctg agcaattccc tcgcccgtct ctatctccaa gaattggtcc 58200
gtgaaaacac taatcattca ccacaaaaac acccgactcg aaataccaga tcccgacgaa 58260
gcgtgccagt tgagttgcgt gccaatagaa caataacaac cacctcatcg gtggaatttg 58320
ctatgctcca gtttacatat gaccacattc aagagcatgt taatgaaatg ttggcacgta 58380
tctcctcgtc gtggtgccag ctacaaaatc gcgaacgcgc cctttggagc ggactatttc 58440
caattaaccc aagtgcttta gcgagcacca ttttggatca acgtgttaaa gctcgtattc 58500
tcggcgacgt tatctccgtt tctaattgtc cagaactggg atcagataca cgcrttatac 58560
ttcaaaactc tatgagggta tctggtagta ctacgcgttg ttatagccgt cctttaattt 58620
caatagttag tttaaatggg tccgggacgg tggagggcca gcttggaaca gataacgagt 58680
taattatgtc cagagatctg ttagaaccat gcgtggctaa tcacaagcga tattttctat 58740
ttgggcatca ctacgtatat tatgaggatt atcgttacgt ccgtgaaatc gcagtccatg 58800
atgtgggaat gattagcact tacgtagatt taaacttaac acttcttaaa gatagagagt 58860
ttatgccgct gcaagtatat acaagagacg agctgcggga tacaggatta ctagactaca 58920
gtgaaattca acgccgaaat caaatgcatt cgctgcgttt ttatgacata gacaaggttg 58980
tgcaatatga tagcggaacg gccattatgc agggcatggc tcagtttttc cagggacttg 59040
ggaccgcggg ccaggccgtt ggacatgtgg ttcttggggc cacgggagcg ctgctttcca 59100
ccgtacacgg atttaccacg tttttatcta acccatttgg ggcattggcc gtgggattat 59160
tggttttggc gggactggta gcggcctttt ttgcgtaccg gtacgtgctt aaacttaaaa 59220
caagcccgat gaaggcatta tatccrctca caaccaaggg gttaaaacag ttaccggaag 59280
gaatggatcc ctttgccgag aaacccaacg ctactgatac cccaatagaa gaaattggcg 59340
actcacaaaa cactgaaccg tcggtaaata gcgggtttga tcccgataaa tttcgagaag 59400
cccaggaaat gattaaatat atgacgttag tatctgcggc tgagcgccaa gaatctaaag 59460
cccgcaaaaa aaataagact agcgcccttt taacttcacg tcttaccggc cttgctttac 59520
gaaatcgccg aggatactcc cgtgttcgca ccgagaatgt aacgggggtg taaatagcca 59580
gggggtttgt tttaatttat taataaaaat gtgtattacg ttactcatgt gtctccatta 59640
cgcatcacag ggggtattta tacccgataa tatacaaaac gcgttttgta cctctaccgc 59700
acccgatatc ttaacggggg ttattatgga atcgtctaac attaacgcgc tacaacaacc 59760
gtcgtctatc gcacatcatc cgtccaaaca gtgcgcttca agtctcaatg aaacagtaaa 59820
agattctccc cccgcgattt atgaagatag gttagaacac acgccggtac aattaccccg 59880
cgacggtaca ccccgagacg tatgttctgt gggacagcta acctgtcgag catgtgcaac 59940
gaaacctttt cgccttaacc gcgacagcca atacgactac ttaaacacat gtccaggggg 60000
ccgtcatatt tcactggcac tggagattat aacgggtcga tgggtttgca tcccgcgtgt 60060
gtttccggat accccagagg aaaaatggat ggcgccatat attattccag accgagaaca 60120
accatcatca ggggatgaag attctgacac cgattaaatt taacttaaat aaaaccttac 60180
cacccataaa aacgccttct gtttgtttaa cacgacaccg cttaacaaaa aaaaacccaa 60240
acacgccttt tatgaatgta atacttttat ttgttggtta acaccgcccc accatcatct 60300
gatttgcaaa catatcggcg tcgtctgccg tggacccctg tattaaaggg gccttggaac 60360
tagcctccac tgcatttaca tcttgtccaa ctgtatctgt atgtggggtg cttgttgtat 60420
tttgggatga gcatagaccc gaaacgcttt gaagctgttt taataaaatc gatattcgag 60480
gatcccgtgt cccctctggt atatttgtat ggtgcgacaa aggcatttgt gtcccatttt 60540
gtgattttag ctctgtaacc tcctgttgca gttttgccac aaccccagca agctcttcgt 60600
gctgaccatt agaaactctg tgtctcctct gccaatatga tggagaaact cgacgtctcc 60660
gatgcgttat atacgttggt tcaccgggaa aatatatatt tgagggaaac tctccgtcca 60720
tttgagactc cccactagaa aaagaatcca attccctttg atccatgctc ttgaaatccc 60780
gttttcctgg acgacggaca tcggttttgt ctggaaaatt tacacacggg gtctgcaagt 60840
caataccccg ttcggcggcc aatgcgttca taaatgcgga catttgcatt tccaaacgat 60900
tgggtggtgg atatcccgga aacccgtacg gtcocccgaa gtgtcccgga gggcaaccat 60960
aaccccctgt attaaatggg aaggcaggcg ggtgtggaga tccatatggc ccgacgatat 61020
actgtccgtt atttggagct ccaattgata cctgcggatt tttagtctgc ccggttaaca 61080
gctgtgaata atacgcggta ggtatcagta caaattcccc tccggttgga acgcccgacg 61140
ggggctgtgg tgagatacca ctagcgttac ctgctacaga agccatatcg ctgtcgttcc 61200
tacacaactg cgtaaccttt aaatgcggaa cagtcttttc acaatcttca tttgattccc 61260
caacacccaa cgcgagatcg tatatgggcc cgccggggtg gaatgtggcg tttataacac 61320
ccgcgttggg taatttagac tccaccccat taacgttggt tatccgagca agtccatatc 61380
cggtgctagc ctgaagataa acgtgaccca taattccggc ttcgcgtcta cgttttgcaa 61440
ccacgtccca tctatctctt aaaagcatat tgttcacggc tgtggataat aacaccttgg 61500
cgagtttatc ttcgctaacc ttccatactt tatttaaacc cgcgtagtct ttaaccagcg 61560
acaataaccg cgctttactt tccatcgata aaacccggaa tggttcaatt gaagattccg 61620
gggtacagtc ataattgacc actgttccaa cgcgtcttcc aacaacacat aacgcaacat 61680
gggtaaaaaa attaccgtct ggtatctcat tcggggacaa tcgttttgaa gacagggata 61740
cggagggtaa gtaatttgtg accaagtata acgcacgttc tagcggagat aatacagaat 61800
ctctatttcc aaaaaaattc gaatgggccg cttcaaacag caccgcatgt agttgagggc 61860
atctaacgat acccaaaaaa aaaggtccgc gtatgtcctc aatgattgcg attacttcac 61920
ccacgacaca gtcttttcga tgatcgatgt ttattggtat tttactagta ggcggcaaag 61980
cggaccgcac aatctctggg gtaatattta attccccttc gtcctttgaa tataaggcta 62040
aatacccagc cacgtataac gcttcacagt tctcttcgtc agcttcagca gccattataa 62100
acaccccacg gaccggatag tgaatactca cggtgtggag gcaaactgag gaatgacacc 62160
caaacagaca aaatatagaa gatcatagtc actgttaacg ttgaactgcg caaggcggcg 62220
actttcttcc aatgccgccc ttacacgcgg ttggtgcatt aacattccaa gtccccgttc 62280
atattgcaac ataacactgt catgtattga taccacggcg gctatgggta gggatgtaac 62340
attttgtcgg cggtgttcta attccaatgc aattaagctt atgagccgat cttggtactg 62400
tccagaagaa atatctatta cggttcttcc taaacttcca cgactaagct gggtatgcgc 62460
gtctaaacaa agagcaacta atccaggaaa catttcagtc agctctgtgg tccgatttaa 62520
cgtatacagt ggtgctatat atcgttcaca taaaaattga aagttattat taccgctttt 62580
aaacttccca tcaaaccccg tcgctccgcg caagattaca ttgttggtag gggttcctgt 62640
tgcttctgac acaatcaaac ccagttgaaa attatttttt agtttatctc cgtatacgtt 62700
cccgttccat aataagcgcc ttaataataa taacgccgta atcgtgtcaa ttgttaacct 62760
taatagagtt tggtcttcca taagaaacac gttttgggcc cgttctaaat acgccgcggc 62820
cgcctgttga atcttgtcca catatgcggt atgattgcga tcaataatgt cattaacccc 62880
aggattaaac tgtccaggtg caggcggtag gacctgcaac cgtataagcg catccataac 62940
agaatgtgac gttaaggcgc cttgatcata ccgcccccca cgagcatgaa actggtcgcg 63000
tggtagacga tcatagcaaa attgataact gtttttattt tcgtgtgttg tcatataatt 63060
cacaaatgtc tcagtatatt ccggtaggtg ctctataagg ttcccgaagg acgaaacttg 63120
aggttcgtgg acactattag atgtcctata cattaaatat aaacataata ccgcacactc 63180
gaacgcggag tacgctctat ctccaacata cattctcccg gcggactgta gacatgttac 63240
cgttgtgttc ataaacgtac gggaaatgcg cccgtcttta caatcaactc cgcgtgcagc 63300
tacgggccta tctaacacaa gccgttcctg cagagtacga taccatggcc cgaaaacaat 63360
ccctggagag ttattgcccc ttgcccttcc caagtacacc agggtgataa aatccacttg 63420
aaagtttgta tcgtactgca acggtgcatc atttttggca atctgtacct cggggtgtat 63480
agactcattg cgtattattt ctgtacgtgt acattcctca gattgtgcat ctgcttcttc 63540
cgcctcggca gcagccgtct ccagggaatc caaaaccttg gccatgcgcg ttagttgttc 63600
ttcgaggggc tttaaacgac gatctatttc cgttggtaac gtaatcgttt ccccgcgaag 63660
gttgtctaat gcggcaacgg ccgccgcatt ttttaacgtt aacgtatttt tttccaaatc 63720
gggattcata cgccctctta actcaaacgc gggagccgtc cagtagtgta tggggaagtt 63780
gggggctata aagttcttag tggtagacaa aaatatccca catttattcg gaaacgagat 63840
agatccgaac ccatatctcg ccgtcatggt gtctgcagca aacaaagtca actggcgtga 63900
atataaaccg gtactgcttt aaaagctgtt ttcttaccca tgggaaaaca tcccggttat 63960
actttgtaaa attccaccac aagcacctaa agaaggcctt ctaaggggta aatccacccc 64020
acargctgca ttttcttcaa actttgttaa agcggaacga tggcatgatt tcgcacgctt 64080
tttcgcaaga gagcatacgt gaattttctt tttgcataga cgtcttcgct ctctaacgga 64140
ccttatcggg ggggtatatt ccgctacatt ctccaaatgc gacgctagca taacaaggtt 64200
tccatgaatc accttcgggg gtaaccgagt tacctgtaac aggttcagac cccgttgaga 64260
tacaaacaca aggagggggg tcaccattat ttcatcagat cccgtgggtg tggtttcctt 64320
tattaaagcc acggtatccc tcagctggcg cataccctcg caaaactggt gatacttagt 64380
aggggtatgt atattagcgc taaaacggca agattttaat tccactataa aacaaacggt 64440
ctttccggca ccactggatt ccgtttgtat aatacaaaca caatcggggc gtcggcgtcc 64500
caaatttact tcaaacgaca ttgatatgcg tacagccctt tgaacatcca cgtgggataa 64560
cggcgacagg agttttgcca gcctcgggtt gaacgcgtcc gcgaaacctc gacgtacgtt 64620
atcaatatcc tttttgagta catcgtaaaa acgagtgtgg caacgttgtc ccaaacgaaa 64680
acacttggcc cgaattcgac tagcggacat atttgaagtt ccgtcccaga agataaccta 64740
agacgcgttt gtctacaata aacatgtcaa cggataaaac cgatgtaaaa atgggcgttt 64800
tgcgtattta tttggacggg gcgtatggaa ttggaaaaac aaccgccgcc gaagaatttt 64860
tacaccactt tgcaataaca ccaaaccgga tcttactcat tggggagccc ctgtcgtatt 64920
ggcgtaacct tgcaggggag gacgctattt gcggaattta cggaacacaa actcgccgtc 64980
ttaatggaga cgtttcgcct gaagacgcac aacgcctcac ggctcatttt cagagcctgt 65040
tctgttctcc gcatgcaatt atgcatgcga aaatctcggc attgatggac acaagtacat 65100
cggatctcgt acaagtaaat aaggagccgt ataaaattat gttatccgac cgacacccaa 65160
tcgcctcaac tatatgtttt cccttgtcca gatacttagt gggagatatg tccccagcgg 65220
cgcttcctgg gttattgttt acgcttcccg ctgaaccccc cgggaccaac ttggtagttt 65280
gtaccgtttc actccccagt catttatcca gagtaagcaa acgggccaga ccgggagaaa 65340
cggttaatct gccgtttgtt atggttctga gaaatgtata tataatgctt attaatacaa 65400
ttatatttct taaaactaac aactggcacg cgggctggaa cacactgtca ttttgtaatg 65460
atgtatttaa acagaaatta caaaaatccg agtgtataaa actacgcgaa gtacctggga 65520
ttgaagacac gttattcgcc gtgcttaaac ttccggagct ttgcggagag tttggaaata 65580
ttctgccgtt atgggcatgg ggaatggaga ccctttcaaa ctgcttacga agcatgtctc 65640
cgttcgtatt atcgttagaa cagacacccc agcatgcggc acaagaacta aaaactctgc 65700
taccccagat gaccccggca aacatgtcct ccggtgcatg gaatatattg aaagagcttg 65760
ttaatgccgt tcaggacaac acttcctaaa tatacctagt atttacgtat gtaccagtaa 65820
aaagatgata cacattgtca tactcgcgtg tacgtgtttt tcttttttat atatgcgtca 65880
tttattacca catcctttaa tcccgccttt atctccctaa aacggagtgg taatattaaa 65940
agccgccaag cctgttggtg ggtgaggagg ggtaagggca cgctgtgtgc ataacgttgc 66000
ggtgatattg tagcgcaagt aacagcgact atgtttgcgc tagttttagc ggtggtaatt 66060
cttcctcttt ggaccacggc taataaatct tacgtaacac caacccctgc gactcgctct 66120
atcggacata tgtctgctct tctacgagaa tattccgacc gtaatatgtc tctgaaatta 66180
gaagcctttt atcctactgg tttcgatgaa gaactcatta aatcacttca ctggggaaat 66240
gatagaaaac acgttttctt ggttattgtt aaggttaacc ctacaacaca cgaaggagac 66300
gtcgggctgg ttatatttcc aaaatacttg ttatcgccat accatttcaa agcagaacat 66360
cgagcaccgt ttcctgctgg acgttttgga tttcttagtc accctgtgac acccgacgtg 66420
agcttctttg acagttcgtt tgcgccgtat ttaactacgc aacatcttgt tgcgtttact 66480
acgttcccac caaaccccct tgtatggcat ttggaaagag ctgagaccgc agcaactgca 66540
gaaaggccgt ttggggtaag tcttttaccc gctcgcccaa cagtccccaa gaatactatt 66600
cttgaacata aagcgcattt tgctacatgg gatgcccttg cccgacatac ttttttttct 66660
gccgaagcaa ttatcaccaa ctcaacgttg agaatacacg ttcccctttt tgggtcggta 66720
tggccaattc gatactgggc caccggttcg gtgcttctca caagcgactc gggtcgtgtg 66780
gaagtaaata ttggtgtagg atttatgagc tcgctcattt ctttatcctc tggactaccg 66840
atagaattaa ttgttgtacc acatacagta aaactgaacg cggttacaag cgacaccaca 66900
tggttccagc taaatccacc gggtccggat ccggggccat cttatcgagt ttatttactt 66960
ggacgtgggt tggatatgaa tttttcaaag catgctacgg tcgatatatg cgcatatccc 67020
gaagagagtt tggattaccg ctatcattta tccatggccc acacggaggc tctgcggatg 67080
acaacgaagg cggatcaaca tgacataaac gaggaaagct attaccatat cgccgcaaga 67140
atagccacat caatttttgc gttgtcggaa atgggccgta ccacagaata ttttctgtta 67200
gatgagatcg tagatgttca gtatcaatta aaattcctta attacatttt aatgcggata 67260
ggagcaggag ctcatcccaa cactatatcc ggaacctcgg atctgatctt tgccgatcca 67320
tcgcagcttc atgacgaact ttcacttctt tttggtcagg taaaacccgc aaatgtcgat 67380
tattttattt catatgatga agcccgtgat caactaaaga ccgcatacgc gctttcccgt 67440
ggtcaagacc atgtgaatgc actttctctc gccaggcgtg ttataatgag catatacaag 67500
gggctgcttg tgaagcaaaa tttaaatgct acagagaggc aggctttatt ttttgcctca 67560
atgattttat taaatttccg cgaaggacta gaaaattcat ctcgggtatt agacggtcgc 67620
acaactttgc ttttaatgac atccatgtgt acggcagctc acgccacgca agcagcactt 67680
aacatacaag aaggcctggc atacttaaat ccttcaaaac acatgtttac aataccaaac 67740
gtatacagtc cttgtatggg ttcccttcgt acagacctca cggaagagat tcatgttatg 67800
aatctcctgt cggcaatacc aacacgccca ggacttaacg aggtattgca tacccaacta 67860
gacgaatctg aaatattcga cgcggcattt aaaaccatga tgatttttac cacatggact 67920
gccaaagatt tgcatatact ccacacccat gtaccagaag tatttacgtg tcaagatgca 67980
gccgcgcgta acggagaata tgtgctcatt cttccagctg tccagggaca cagttatgtg 68040
attacacgaa acaaacctca aaggggtttg gtatattccc tggcagatgt ggatgtatat 68100
aaccccatat ccgttgttta tttaagcaag gatacttgcg tgtctgaaca tggtgtcata 68160
gagacggtcg cactgcccca tccggacaat ttaaaagaat gtttgtattg cggaagtgtt 68220
tttcttaggt atctaaccac gggggcgatt atggatataa ttattattga cagcaaagat 68280
acagaacgac aactagccgc tatgggaaac tccacaattc cacccttcaa tccagacatg 68340
cacggggatg actctaaggc tgtgttgttg tttccaaacg gaactgtggt aacgcttcta 68400
ggattcgaac gacgacaagc catacgaatg tcgggacaat accttggggc ctctttagga 68460
ggggcgtttc tggcggtagt ggggtttggt attatcggat ggatgttatg tggaaattcc 68520
cgccttcgag aatataataa aatacctctg acataaaaaa catgtataat aaaaagtcac 68580
tataaacgta ttctctacaa tactttattc gcgaataata cacactacct ttgggttttt 68640
ttcccgtccc caaatggtgt ttggtgcact ctaccaaaaa atagagcgcc taaatatgct 68700
atataacgcc tcccagcaaa atacggttca aaggcattac ccgatattgt attgtagtac 68760
agggcaatgg gaattgatga tcccaataaa cggcatagac gcacagcgcc gttatagcag 68820
gggtctccag agtacagggt atctaagtac cgggatatct catactcatg cctttccgtg 68880
acagaaacat caaccggaac agtatccgat aaaccaactc ctgtttttgc aaggcgtaaa 68940
attcgcacac cttccttttt tgcaagatgt gacgtttcct tgtaacaggg aagctggggg 69000
agtggtaaga acaacaaagt ttcagccaac gtgccaataa agcccacttc cctcaagagg 69060
ctgtttgctg tatccacaat ggtccgtatt aaatcttgag caacttgatc cgtgtcatca 69120
tcactgggta acgcgttaac ataactacgc gttaaatctt caataacggc ataacaatta 69180
aacgcttccc accgagacag tatatattga acaatcacga accgttgaca ggacgtcaga 69240
tcacgtccgt aagcatgccc gaaaaatgga agttcccccc gttcgccata taccgcaaca 69300
actgcggtat atatcgtctc acgggcttca ttaagttcat cttcaagtcc aggccatttt 69360
ctggctttaa atataacctc gtccgcaaaa aaaaccgcac atgataacgc gcggatacaa 69420
tgagtagtgg ctttatggcg aggatcccaa atgtccatta cccgggggat ggtcctaatc 69480
tgtacaaagt tacttagtgt aatatgatcg gacttcttac gccgtctagg ctgtttctca 69540
gaatacggtt cacccgaaat cggcacatca tctgctttta cgtcttccgt aaccacatca 69600
gcagcgcgcc gactaacaat tatacttgtt ttttcatcgt cgttacttcc gttaagcgcg 69660
tctcgtatct cgggcgtccc gtcgaataat ccactcacta gctcctgcaa accttctggt 69720
aactccaaca tacgcatata caccaatgaa aaactggctt cgtttggtac gtacataaag 69780
ccatttgtgg tattaatggc ggtgggtgtt ggaaacaatt ttagcttatt ctcgcgcgta 69840
acatctaccc ccgccaccaa tgttaaatgc gtcacgggga gggacacgag ataatctgcg 69900
agcgtagggt cctccacttc aacatcaaat gttccgcaaa ggtcgcgatc caccgccccc 69960
gatcccgctg caagtaaggc cactcgatcc aaaaacacgc agttattatt ggatgatacc 70020
gcccatgtct tcccggtgcg attgagctca cttcgaacgt aactggcaac agatctgtca 70080
ccgggtccga ccccgcgaac aacatgtcca aattttgcga tctcgcctcc atgtttgcgg 70140
ggtatggaaa ttaagcatcc cccgcatata aaatacgccc tggtagcacg ctcgttaaaa 70200
taaaacgtta cgccgttata agatacggtt gaatgatatg gaaattccat attaaagcgt 70260
ttatcggaac attaacctcg aacttgccgt cccgtgatcg tgtgatcgcc aaccttaggt 70320
ccacaccgaa tatgagaaat atataactac acgcaaacat tcaaaacacc gtggtatcat 70380
taacgtcata tgaaaagatc caatcaatcc aatcaaccac acctcctacc gtttagcacg 70440
tcagctatgt gacatgctcc aaacatacgt aaacatttag agagggtgtt ataacagtct 70500
gtcaggcggg gtatattcta cataatacaa ggatcggctt taactttgtc aacattttta 70560
ctttggacta taaactgcga ctgaacgtta tgaacccacc ccaagcccgc gtctcggaac 70620
agacaaagga cttgcttagc gttatggtta accagcaccc cgaagaggac gcaaaagtgt 70680
gtaaatccag tgataattca ccgctttata acaccatggt tatgttatcg tatgggggtg 70740
atacggactt actattaagc tctgcatgta cccgcacatc taccgtaaac aggtcggcgt 70800
ttacgcaaca ctccgtgttt tatattatat ccacggtgtt gattcaacca atatgttgta 70860
tcttcttttt tttttactat aaagcgacac gctgtatgct cttattcaca gccgggttac 70920
ttctgacgat tctacatcac tttcgactta ttattatgtt attgtgtgtc tacagaaata 70980
tacgatcaga cctgctaccc ttatctacat cccagcaact gctgcttgga attattgttg 71040
tgactcgaac aatgctattt tgtattacgg cgtattatac tctttttata gacacccggg 71100
tgttcttttt gattaccgga cacttgcaaa gtgaggttat ttttccagat agcgtttcaa 71160
aaatacttcc tgtgtcgtgg ggtccaagtc cagccgtgtt actggtaayg gcggcagtta 71220
tttacgctat ggactgtttg gtggacacgg tatcctttat tgggccaagg gtgtgggtcc 71280
gtgttatgtt aaaaacatct atttcgtttt agtccatttc aataaatgta ctataattgt 71340
tcagtctaaa aataatgttg ggtatttata attaccgccc ccgtgttact tggaaacacc 71400
catacatatg ttccactcta catcaaactt ctcgcagttt tcttgttccc gcacacgttt 71460
acacgtccgg attcaagtcg caacgctgct gacaaaatga caacggtttc atgtcccgct 71520
aacgtgatta ctacaacgga atctgatcgt attgctgggt tatttaacat cccagcgggg 71580
atcattccaa ctggaaatgt gctgtcaacc atagaggtgt gtgcacaccg ttgcattttt 71640
gattttttta aacaaatacg atcagatgat aacagccttt actcggctca attcgatatt 71700
cttttgggga catactgcaa tacattaaac tttgtgcgtt ttctagaact tggactgtct 71760
gtcgcttgca tctgtactaa atttccggag ctggcttacg tgcgagatgg cgttattcaa 71820
tttgaggtac aacaacccat gatagcacgt gatggcccac atcccgtcga tcagcctgtt 71880
cataattata tggttaagcg gatacacaag cgttcgttaa gcgctgcgtt tgcaattgca 71940
tcggaagcgt tgagtttgtt aagtaacaca tatgtcgatg ggacagagat tgactcatcg 72000
ttacgtataa gagctatcca acagatggct cgtaatttac gcaccgtttt ggactcattt 72060
gaacgaggca ctgccgatca acttcttggt gttctattgg agaaagcccc accgctatcg 72120
ctgctttcac caattaataa attccaaccc gagggacatc taaatcgtgt tgcacgcgcg 72180
gccctacttt cggacctcaa acgtagagtc tgtgcggata tgttttttat gacccgacac 72240
gccagggaac ctaggctgat ctctgcgtat ctgtcggata tggtttcgtg cacccaacca 72300
tcggtgatgg tatcacgaat aactcataca aacactcgcg gacggcaggt tgacggtgtg 72360
ttggtaacaa cagcaacctt aaaacggcaa ctattacagg gaattttaca aattgacgac 72420
accgccgctg acgtaccagt aacatatggc gaaatggttc tacaggggac aaacttggta 72480
accgcccttg tgatgggaaa ggccgtccgc ggaatggatg atgtagcccg ccatctcctt 72540
gatataaccg accctaacac gttaaacata ccgtctatac ccccacaatc caactccgat 72600
tcaacgacag ctgggcttcc ggttaacgcc cgtgttcctg cggatttagt gattgttggg 72660
gataaacttg tattcttaga agcattagaa cggcgggtct accaagctac gcgcgttgcc 72720
taccctctta ttggaaatat agatattacg tttatcatgc caatgggagt gtttcaggca 72780
aactccatgg acagatatac acgacacgcc ggcgattttt caactgtatc cgaacaggat 72840
ccacgtcaat ttccacccca agggattttt ttttataata aagatgggat attaacacag 72900
ttgactcttc gtgatgcaat gggtaccatc tgccacagtt cattgcttga tgttgaggcc 72960
acacttgttg ccctccgcca acaacattta gatcgtcagt gttattttgg tgtatacgtg 73020
gccgagggta cagaggacac attggatgtt caaatgggga ggtttatgga aacgtgggca 73080
gatatgatgc ctcatcaccc tcattgggta aacgaacatt taacaattct acagtttata 73140
gctccgagca acccgcgtct aaggtttgaa ttaaaccccg cctttgattt ttttgttgca 73200
ccgggggacg tagaccttcc cggaccgcag cgtcccccgg aagccatgcc aaccgttaac 73260
gcaacattac ggattatcaa cggaaacatt cccgtgcctc tatgtcccat ttcatttcga 73320
gactgtcgcg gaacccaact cggtttggga agacatacaa tgaccccggc aaccattaaa 73380
gccgtaaagg atacatttga agaccgcgca tacccaacta ttttctacat gctagaggct 73440
gttattcatg gaaacgaaag aaacttctgt gcgttactgc gactgttaac acagtgtatt 73500
cgcgggtatt gggagcaatc ccacagggtg gcatttgtaa ataactttca catgttaatg 73560
tacataacta catatctcgg aaacggtgag cttcccgaag tctgtattaa tatatatcgg 73620
gatttactgc agcatgtaag agcattacgc caaactataa ccgattttac aatacaagga 73680
gagggccata acggcgagac ctcggaagcg ctaaataaca tccttacgga tgacacgttt 73740
attgcaccta ttctatggga ttgtgatgcg ttaatatacc gtgatgaagc cgcccgagac 73800
cgactccccg caattcgtgt aagcgggcga aacggatacc aagcccttca ctttgtggat 73860
atggccgggc ataacttcca acgacgcgat aatgtgttaa tccacgggag acccgttcgg 73920
ggagacacgg gtcagggtat tcccattacc ccacaccatg accgtgaatg gggtattctc 73980
tccaagattt actactatat tgtcattcct gcattttccc gcggttcctg ttgtacaatg 74040
ggcgtgcgtt atgatcgcct ataccctgcg ttacaggcag ttatcgttcc ggaaattccc 74100
gctgatgaag aagccccaac taccccagaa gatccaagac accctcttca cgcacaccaa 74160
ctcgttccga actctcttaa cgtttacttc cataatgcac acctaaccgt tgatggtgat 74220
gcattgctca cactacaaga gttaatggga gatatggctg aacgaacgac ggccatttta 74280
gtatcaagcg cccccgatgc gggagccgcc acggcaacaa ccagaaatat gagaatatat 74340
gacggagcgc tttaccatgg ccttattatg atggcatatc aggcgtacga tgaaaccatt 74400
gcaacgggta ctttttttta tcccgttccg gtcaaccctc tgtttgcatg tccggaacat 74460
ttggcatcat tgcgtggaat gacaaatgct aggcgggttt tggcaaaaat ggtaccacca 74520
atccctcctt ttctgggagc caaccaccac gcaactatac gccaacccgt tgcctaccat 74580
gtaacgcata gtaagtcgga ttttaatact cttacatatt ctcttcttgg agggtatttt 74640
aagtttacac caatatctct tacacatcaa ctacgaacgg gatttcaccc cgggattgcc 74700
tttaccgtag tgcgccagga tcgctttgcc acagagcaac ttttatatgc cgagcgtgct 74760
tctgaatcgt actttgtcgg acaaatccaa gtacaccatc atgatgctat tgggggggta 74820
aactttaccc taacccaacc cagagctcac gtggacctgg gagtcgggta tacagctgta 74880
tgtgccacag cagccctgcg atgccctctc acggatatgg gcaatactgc ccaaaatctt 74940
tttttttcac gaggaggagt gccaatgtta catgataacg ttaccgaatc gttgcgtcgt 75000
ataacagcat cggggggtcg cttaaatccc accgaacccc tacccatctt cggcggacta 75060
cgtcctgcta catcggcagg aattgcacga gggcaagcct ctgtgtgtga gtttgtggcc 75120
atgccggtgt ccactgacct acaatatttt agaactgcat gcaatcctag aggtcgagca 75180
tctggaatgt tatatatggg tgaccgtgac gccgacatag aggctataat gtttgatcac 75240
acacaatcgg atgttgctta tacagatcga gcaactctta acccatgggc atcacaaaaa 75300
cattcatacg gtgacaggct atacaacgga acatacaacc ttacaggcgc ttctcctatc 75360
tacagcccat gctttaagtt ttttacacca gcggaggtta acactaattg taatacactg 75420
gatcggcttc taatggaggc aaaggctgtg gcgtcgcaaa gctccaccga cactgaatat 75480
caatttaaac gccctcccgg ttctaccgaa atgacacagg atccgtgtgg cctttttcaa 75540
gaagcatatc caccactatg ctcaagcgat gcggccatgt tacgaacggc tcacgcggga 75600
gaaaccgggg cagatgaagt tcacttagcc caatatctga ttcgagacgc gtcgcccctt 75660
aggggatgtc ttcctcttcc gcgataattt caccacgccc acatacccac tcccaataaa 75720
agccctgtag agcgcattgg catcttactt gagatttgga tacgctcggc cgacttggtc 75780
tgtttcacgc ttccttaaac aacatggcta tgccatttga gatagaggta ttgttaccag 75840
gagaactatc cccggcggaa acatctgcat tacagaaatg tgagggaaaa attattacct 75900
tctcaaccct gcgtcatcga gcttcactgg tggatatagc gctgtcgtca tattacatta 75960
acggtgctcc accagacacg ctctcgctgt tagaggcata ccgaatgcga ttcgcggcag 76020
ttataacacg ggtcatcccg ggaaagttgt tggcgcatgc cattggcgtg ggtactccta 76080
cacccgggtt gtttattcaa aatacatccc ccgttgatct ttgtaatggc gattacatct 76140
gcttacttcc tccggttttc gggtccgcag actcaattcg cttggactct gtaggactgg 76200
aaattgtttt ccctttaacc atcccccaga ccttaatgcg agaaatcatc gccaaagtgg 76260
ttgcacgggc cgttgagcgc acggccgcgg gtgctcaaat tttaccccac gaagttctac 76320
gaggcgcgga tgtcatttgt tacaatggaa ggcgttatga actcgaaaca aatttacaac 76380
atcgggacgg atcggatgcg gctattcgca cattggtttt aaatctaatg ttttccataa 76440
acgagggatg tctgctttta ttggcgctga ttccaacttt gttagttcaa ggagcacacg 76500
acggttatgt aaatttattg atacaaacgg ccaattgcgt tagagaaacc ggccagttaa 76560
ttaatatacc gccaatgccg cggattcaag acggccatcg ccgatttccc atatatgaaa 76620
ctatttcatc ttggatatca acatcatcta gactggggga taccttggga actcgcgcaa 76680
ttttacgcgt ctgtgtgttt gatggaccct ctactgttca tccgggagac cgcacggccg 76740
tgattcaagt gtaaacaggt gttaataaaa acacaaccag tctagttaca tttcacgcgt 76800
cttgttttta tttaataggc ataaacacgg aatccggtat acatgaactg ccaatataca 76860
cggacataat taatgcaacc atcagatcat ctgacattgt tcccgtggta cctttacccg 76920
tgtaagtttt tgtgtctaga ttacccatac cgcctttaat tacctctgtc aggttatcca 76980
actgtttaca tagatactcc acggggtcta cacctaactt tactgttagg gatacaagct 77040
cctgtgaggc tattatattt ccggagttaa atcgtttaac aaaatagtct acggccggcg 77100
ttttttgttt ttgtaataaa aaaaaagggt acgccacgct acatccggga ggtatggaat 77160
gataaaacag taacactgga gcggaagata gcacgtttcc cttttcgagg acagcaaact 77220
gttgtgctat agccaacgat atggcaactg cagaatcctg gctgctgttt ccctctatag 77280
aaacgtgtac gtttgtaaat gtattggggt gtaaagcgag tatgtggcct aagcattgag 77340
taacgcaacg ccctatctca ctggaagacg tgccagttaa agctctaaga aaaaagtgct 77400
ccaatccaaa tataatccaa tccgacttat aacgaccaac aatcgctaca ccagtaccag 77460
acgctcgtgt atttgaggta aatgcagggt ctacgtaaac gtacaacact gacgataata 77520
tagcacaatt cgcaacggtt gacggccgat ataaaataaa cctctcacgg gcagtttttg 77580
taaataatgg ccggtcaaac cccacacccc cagaattctg tttacgccca cctacaattt 77640
cctgcacgaa ggagtcggcc ataaataaat ctgcagtgcg ccgcatggct ccatccattg 77700
tgatgaaaac cggcttattt aatacataac acgaacaagc tgtgacatcg ctatgtgcta 77760
aaacacgcgg catgtgatcg tcgcatacat atgtaacaac gtttaacaac tgatccgacg 77820
atccacgtaa gttatacaaa aaacttgtac ttgcttttcc ggtatttgtt gatgaaacaa 77880
aaataatttt acaattggtt tgatttaaaa atccgactat agtttgtaca gcatcaggtc 77940
gaataaaatt agcttcatcc acaaacagaa gattaaaatc ttgacctcgg ataccctgga 78000
acgatagaaa gatatatagt taccccacca aagtttaaat gtatccttaa ataccacgta 78060
cgtaaaaaat gtttgaatac gtacatattt cttttttttt ccagtacaac catatccggt 78120
gtataatgga agcccatttg gcaaatgaaa ccaaacatgc actttggcat aatgatcaca 78180
caaaaggatt actacacgtt gtgataccta acgcggggct tattgcggcc ggaatagatc 78240
ccgcattact gattttaaag aaacccggac aacgcttcaa ggttgaagta caaacaagat 78300
atcatgctac aggtcaatgc gaaccgtggt gtcaagtttt cgccgcgtac attcccgata 78360
acgccttaac aaatctctta ataccaaaaa cggaaccatt tgtttcacac gttttttcgg 78420
ccacgcataa ttcaggggga ttgattttat cattgcctgt ttatcttagc cccggtttat 78480
tctttgatgc atttaacgtt gtagcgatac gaataaatac tggaaaccgc aagcaccgtg 78540
atatttgtat tatgtatgca gaactaatcc caaacggaac gcgttatttt gctgatggac 78600
aacgggtact tttattatgc aaacagctga ttgcgtatat ccgatgcacc cctcgtcttg 78660
catcgtctat aaaaatatac gcagagcata tggtggcagc catgggtgaa tcacacacgt 78720
caaatgggga caatattgga cccgtttcat ccataatcga tcttgatcga cagttaactt 78780
ctggaggtat tgatgactcc cctgctgaaa cacgcataca ggaaaataat cgggacgtcc 78840
ttgagctaat aaaacgggcc gtaaacattg ttaactccag gcaccccgtc cgaccttcta 78900
gttcccgcgt tgcatctggg ttgcttcaaa gtgcaaaggg ccacggagcg caaacttcca 78960
acacagatcc gatcaataac ggttcctttg atggcgtcct tgagccgcct ggacaagggc 79020
gatttacggg aaagaaaaac aattcgtccg ccagcatccc acctttacaa gacgttctat 79080
tgtttacccc agcttcgaca gaaccccaaa gtcttatgga atggttcgac atctgttatg 79140
cccaattagt tagcggggac actccagcag atttctggaa acggcgtccc ctatcaattg 79200
taccgcgaca ttacgcagaa tcccccagtc cgttgattgt agtatcttac aacggatcct 79260
ctgcctgggg aggacgtatt accggaagtc caattttata tcactctgca caggctatta 79320
ttgatgctgc gtgtataaat gcccgggttg acaatcccca aagcctacat gtgacagctc 79380
gccaagagct agtcgcgcgt ttaccgtttt tggctaacgt cctaaataat caaaccccct 79440
tacccgcctt taaaccaggc gccgaaatgt ttttaaacca ggtatttaaa caagcgtgtg 79500
tgacatcgct aacccaaggt cttataacgg agttacaaac gaacccgact ctacaacaac 79560
tcatggaata tgatattgca gattcttccc aaacggttat tgatgaaatt gtagcccgca 79620
caccagacct gattcagact atagtttcgg tgttaacgga aatgtcaatg gatgcgtttt 79680
ataacagctc cttgatgtat gcggttttgg cgtatctgtc atctgtatat acacgaccac 79740
aaggtggggg gtatataccc taccttcacg cttccttccc atgctggtta ggtaatcgtt 79800
ctatatattt atttgactat tataattcag gaggggaaat acttaagctt tccaaggtcc 79860
ccgttcccgt agccttagaa aaggttggta ttggtaattc cacacaactg aggggtaaat 79920
ttatacgcag cgcggatatt gttgatattg gaatttgttc taagtattta cccggtcaat 79980
gttacgcgta catttgtcta ggatttaacc agcaattaca atccatttta gttttaccgg 80040
ggggatttgc ggcatgtttt tgtattaccg ataccctaca ggcagcacta cctgcatcgt 80100
taatcggacc tattctagac agattctgct tctctattcc caacccccat aaataaatta 80160
gtgtcactat aaaaacataa caccagaatc tcttcatatt taattttacg tcatttctcc 80220
cgtttccacc ccctcttaaa atataaaata accgggtggg tggcattaaa cccacaagta 80280
cccgggcggc aatccgctag actgtttttc tgctcatgga attacaacgc atatttccgc 80340
tgtacaccgc tacgggtgca gcgcgcaaat taacccccga ggcagttcag agactctgcg 80400
atgcattaac gctggatatg ggattatgga agtccatcct gaccgatccc cgggtgaaaa 80460
taatgcgatc aactgctttt ataactttaa ggatcgctcc gtttatcccc cttcaaacgg 80520
atactactaa tattgccgtt gttgtagcca caatttacat cacgcgccca cgtcagatga 80580
acttacctcc gaagactttt catgtaattg taaattttaa ttacgaggtc tcgtacgcaa 80640
tgacggcgac tttaagaatt tatccggttg aaaacataga ccatgttttt ggagcaacgt 80700
ttaagaaccc gatcgcgtac ccccttccaa catctattcc ggatcctcga gcagatccca 80760
cccccgcaga tcttacacca acgccaaact taagcgacta cttacaaccc ccgcggcttc 80820
cgaaaaatcc atacgcatgt aaagttattt ctccgggagt gtggtggtca gacgaacgaa 80880
ggcgtttata tgtactggct atggaaccta atttaatagg gctatgtccc gccggatggc 80940
atgctcggat acttggctct gtattaaatc gactcctcag ccatgcggac ggatgtgatg 81000
aatgtaatca tagagttcac gtgggggcac tgtatgcgtt accccatgtc acaaatcatg 81060
cggaaggttg tgtgtgttgg gctccgtgta tgtggagaaa ggccggtcag cgggaattaa 81120
aagtggaggt agacattggc gctacgcagg ttctttttgt agatgtcacc acctgcattc 81180
gaattacgag tactaaaaat cctcgcatta ccgcaaatct tggcgacgtt atagcgggaa 81240
ccaacgccag tggtctctct gtaccagtaa attcatctgg gtggcagctt tatatgtttg 81300
gagaaacatt aagccgggct attattaacg gctgtggtct gcttcagcga atttgcttcc 81360
ccgagacaca aagattatcg ggtgaaccgg aacctacaac cacctagtat accttaactc 81420
aaccgccgtt gtggaaaggt atatgtcaac atttacagta atatattaaa ggttaaattt 81480
ataaaacact cacgtttgtg ttgtgacttg acgcgaacac cgctgtgctg taagacccgt 81540
cggtaaatga aaacgtaata gattcgcctt ttacatgatc cacgtaattt gccccaaacc 81600
actgttccag gcgagacttg ataccctcaa acacgggttc cgttgctttg cgtatatgag 81660
ccgtataacc cactttaatt cctctaaacg tggccattac taaagctatt aatggtacaa 81720
gaaaccatgt tttcccatgt ctacgtggta ccaaaaacac agttgatttt tgtttgaagt 81780
gttctaaaac actgtcagaa acacttggcg tgttaaacac tgtacgcaga aagcagtcaa 81840
ctctgtcggc atgatcgccc aatagcaccg atgaaataaa atgcgtggtg tgcatgagga 81900
tcattttttg aaacagttcc aacgtcccct tatatctgcc atagattgga acgtcaacct 81960
ttgcgcgttt gccatgactt ccacactctt caatactctc aaaagatgtt tccacaaggt 82020
acgaaaaccg ttgtgtaaag gtagacaact gacagaaact atccgacaga gaaaacgcgc 82080
gaaatgtgtt cataacaccg ctatacgcat ttcgatgagg tgctgcttct tccggtgaat 82140
attcataaaa ctgtacacta ctgacagcct tttttaattc rgggcttacg tttgcattta 82200
ccgaatatcg ccatggtttc aaaactacat tgggggtaca gttgtaccct gttgacgata 82260
gaaacgcgcc aaacattgcc cgtcgagcag tagccgagaa cagtggaata tattcacaac 82320
agttgtgaag cgttccaatt ccgggaataa cggcctgatg acgtcgggtt acatctatag 82380
caaaattcag aaacgggatt tgggttgcgt ttcccagaga cccttgccgc gtggaacacg 82440
gggtagggga ctccaacgtc ccaaagcgtt catccctacg acgctttaga cgttcaaaat 82500
atcttacaga ttcttcacca agcgtacgac caaacattat caatgacatt taacatcaat 82560
tcacggaatc cgcctcatct cttgtaagca gtaaaacagg aagccgcgtc atcttacgta 82620
ctcgttacgt atatatcata aacattttca gggccgcatt cattcacttt ggtcatgtca 82680
ggccacactc caacctacgc ttctcatagg cgtaaccgtg tcaaactagt tgaggcgcat 82740
aaccgcgcgg ggttatttaa agaacggacc ctcgatctaa tccgtggggg tgcgagtgta 82800
caagatccag catttgtgta tgcctttact gctgcaaaag aggcctgcgc cgatttaaat 82860
aaccagctcc gctctgcagc tcgcatagct tcagttgaac agaagattcg tgatatacaa 82920
tccaaggttg aggaacaaac aagtattcaa cagattttaa atacaaacag acgctatata 82980
gcacccgatt ttattcgcgg tttggataaa acagaagacg ataataccga taatatagac 83040
agactggaag acgcggtagg accgaacatc gaacacgaaa atcatacttg gtttggagaa 83100
gacgacgaag cgttacttac acaatggatg ctgacgacac accccccaac ctccaaatat 83160
ctccaactgc aggacctttg cgttcccacc acaataccga cggacatgaa ccaaatgcaa 83220
ccgcagccga tcagcaagaa cgagaatcca ccaaccccac acacggatgt gtaaatcatc 83280
catgggccaa tccgtcaact gcaacatgca tggaatcacc agaacgatca caacagacaa 83340
gcttattttt attaaagcac ggcttaacga gagatccaat acatcaacgc gaaagggtgg 83400
acgtttttcc acaatttaac aaacccccat gggtttttag aatttccaaa ttatcccgtt 83460
taattgtacc catcttcacg ctcaatgaac agttatgttt ttctaaatta cagattcgag 83520
atagacccag gtttgcggga cggggaacgt atgggcgtgt tcatatatac ccatcgtcaa 83580
aaatagctgt aaaaaccatg gacagtcgtg tttttaatag agagttaatt aacgcgattt 83640
tagcgagtga gggttctata cgagcagggg aaaggctagg tatttctagc atagtttgcc 83700
ttttaggttt ttcgttacaa accaaacagc tactgtttcc ggcatacgac atggatatgg 83760
atgaatacat tgttcgcctg tccagacggt tgacaatacc tgatcacata gacagaaaaa 83820
ttgcccatgt atttttagat ttggctcaag cgttgacgtt tttaaatcga acgtgcggcc 83880
tgacccacct agatgtgaaa tgtggcaata tttttcttaa cgtcgacaac tttgcctcgt 83940
tggaaataac cacagcagta atcggagact atagcctagt aacattaaat acgtattccc 84000
tttgtactcg agcgatattt gaagttggaa atccatccca cccggarcac gtactacgcg 84060
taccccggga tgcatcgcag atgtcatttc gtttggtgtt gagtcatgga acaaaccaac 84120
cccctgaaat cttgcttgat tatattaatg gaacgggcct tactaaatat actggaacct 84180
tgccccaaag agttggactt gcgattgatc tttatgcatt gggccaagca ctcttagaag 84240
ttatcctgct aggacgtctt cccggacaac tgcccatttc agtacatcgg accccgcatt 84300
atcactacta cggtcataag ttatcaccag atttggcgct tgatacgctg gcatatcgat 84360
gtgtcctggc gccatatata ctcccatctg acatccccgg ggacttaaat tataatccct 84420
ttatacacgc cggagagctg aacacccgta tttcccggaa ttctttacgc cggatattcc 84480
agtgtcacgc agtgcgttac ggcgtaacgc actcaaagct tttcgaaggc atacgcattc 84540
cggcctcatt atacccagcc actgttgtta cgtcgttgtt gtgtcacgat aattcagaaa 84600
tacgctcgga tcacccttta ttatggcacg atcgggattg gataggatcg acataagccc 84660
ccagccagcc aaaaaaattg cccgtgtggg aggtctacag cacccttttg taaaaacgga 84720
tattaacacg attaacgttg aacaccattt tatagacacg ctacagaaga catcaccgaa 84780
catggactgt cgcgggatga cagcgggtat ttttattcgt ttatcccaca tgtataaaat 84840
tctaacaact ctggagtctc caaatgatgt aacctacaca acacccggtt ctaccaacgc 84900
actgttcttt aagacgtcca cacagcctca ggagccgcat ccggaagagt tagcatccaa 84960
attaacccaa gacgacatta aacgtattct attaacaata gaatcggaga ctcgtggtca 85020
gggcgacaat gccatttgga cactactcag acgaaattta atcaccgcat caactcttaa 85080
atggagtgta tctggacccg tcattccacc tcagtggttt taccaccata acactacaga 85140
cacatacggt gatgcggcgg caatggcgtt tggaaaaacc aacgaaccgg cggcacgagc 85200
gatagttgaa gcattgttta tagatccggc tgatatccgt actcctgatc atttaacgcc 85260
agaagctaca actaagtttt ttaattttga catgctcaat accaaatctc caagtctcct 85320
tgtgggtaca ccaagaatcg gaacgtatga atgtggactt ttaatcgacg ttcgaacggg 85380
acttataggc gcgtcgttgg acgttcttgt atgtgacagg gaccctttaa ctggcaccct 85440
aaatccccac cctgcagaaa ccgacatttc attttttgaa attaaatgtc gtgctaaata 85500
cctctttgat ccagatgata aaaataaccc gctcggtcgg acgtacacca cgttaataaa 85560
tagacctaca atggcaaatc tacgggactt tttatatact ataaaaaacc catgtgtaag 85620
cttctttgga ccctcagcaa acccaagtac acgcgaggcc ttaataacgg atcacgttga 85680
atggaaacgt ttaggattta aaggtgggag ggcccttaca gaactcgacg cccatcattt 85740
gggcctcaat cggacaatct catcccgagt gtgggtattt aatgatccgg acatacaaaa 85800
ggggacaatt acaaccattg catgggccac tggagatacg gctcttcaaa ttcctgtatt 85860
tgccaatccg cggcacgcta actttaaaca aattgccgta caaacctatg tattatccgg 85920
ttactttcca gcgctaaaac tacggccctt ccttgtcacc tttataggac gtgtgcgccg 85980
accacacgag gtgggagtcc cattgcgcgt cgatacacaa gcggctgcca tttacgaata 86040
taactggccg actatcccac cccactgtgc ggttccggtt atagccgttc taacgcctat 86100
cgaagttgat gtgcctagag tgacaaaaat acttaaagac acaggaaaca acgcgattac 86160
atcagcattg cggtcattgc gatgggacaa tcttcatcca gcggtcgagg aggaatctgt 86220
ggattgtgca aacggtacaa cgagcttgtt acgtgcaacg gagaaaccgt tgctttgaac 86280
tcagagttct ttgaagactt tgactttgat gagaatgtaa cagaggacgc cgataaatcc 86340
acacaacgcc gcccacgagt gatcgatgta acaccaaaac gaaaaccttc gggaaagagc 86400
tcccattcca aatgcgcaaa atgttaaacc ctgataaacg ttctaataaa aacatcaaat 86460
catggttggt tactgtgaat gtttgtttta ttgcttgggg ggttacaagt acaacccacg 86520
ctactcccac ccactgtttg atcgctcgta taacagctca tcctcgcggt ccgtttcata 86580
tgttgagtca ttttcataga cgtagccgta gccttgtgat gggtaatttg tgcggcgaga 86640
atttctatgt gcaggtttta cttttcgtat gtatccccgt acccgctcgg gtactcttct 86700
tacggcaccg tagaaccgac tgcgtttctg tcgatgatac acatatgcac gcatcaatct 86760
gagaagcaac atgacaacgg aaaacacggc caggcaagcc aaggttcccc gagttgtggg 86820
aattaaccgt ggagattgaa ccgatatagg gtcatataat cggtccatat acgagtgcgc 86880
ggcggttccc aacgtagcac aggccacgag cgttcccagg gacggtccta ttaacacgtg 86940
tatataatgc gccaaaatta attctgatac tataagatat acaactgaca atgtactaaa 87000
tgtagacatg gccacggaca ccgatgacca cagtcccgta tgtagatgat tcgccaccac 87060
aagttccagc attaatgata caaataggat acatatcgcc atcaacgcag ccatcaaatt 87120
cacgaacact gcgcgcgtag gccccgcaag gcgatataaa aagacgctct gctgtcgtaa 87180
atttgcgacc gcttttatgt tcgtttcgtc caattttccg cgtccrcaaa aatacgttgt 87240
aaatattaca cytgtcgcaa aatgtccaag atataatgta gcagccacgc cgatttgctt 87300
gtaagctaat aataacacaa cggcgtttaa taaccacaat gacaaaagac cccaaaaaag 87360
tgttgtggga tctacaacta accatgcaac accggagctt tgccggacac gttgattttt 87420
cgtttctcgg tgtataatcg cggccgtgat cagtgtatat accgccatgg ccattgccgt 87480
taaagccgtg tagtaagtaa atgccacaac gctatgtggt tccaaaaaca aaaccggggc 87540
gctgtatcca cctctatttc cggaccatac ccccccatct agggtggcgt taaataactc 87600
ataatcaact acggcagcat aaaaacaagg gatcccggta tattcagaag aggcggcaat 87660
taacgtagcc aggagcatta ccgcacccaa agtgaacatc atcacctgaa ttatccaaat 87720
tcgccaatta agcgtatcca tttgatgatc taacgcttcc acctcgggtg tcgtggtgtc 87780
gtacggtgag actttttcag aacgcggccc cttcttttga gttcccatgt ctcccaacac 87840
cggggagagc aacgccgccg tctatgcgtc cagtacacagc tcgcgcggg cgttatatgg 87900
aggggatctg gtttcgtgga ttaaacacac ccacccggga attagcctgg aactgcaatt 87960
ggatgttcca gtaaaactaa taaaacctgg tatgtcacaa actcgcccgg taaccgtcgt 88020
acgtgcccct atgggctctg gtaaaacaac agccttgctt gagtggcttc aacacgcgtt 88080
aaaggcagat attagcgtac tggttgtctc atgtcgccgt agctttaccc agacgttgat 88140
tcaacggttt aacgatgcag gcctctccgg attcgtaaca tatttgacat ccgagacata 88200
tattatgggt tttaaacgtt tgattgtgca acttgaaagc ctacaccgcg tatccagcga 88260
agctatcgac agctacgacg tattaatact ggatgaggta atgtcagtga ttggacaatt 88320
atactccccc acaatgagac gtctttccgc ggttgatagc ctattatatc gtcttttaaa 88380
tcgctgttct caaattatcg cgatggatgc tacagtaaac tctcagttta ttgatttaat 88440
ctccggattg cgtggagatg aaaacataca cacaattgtg tgtacatacg cgggagttgg 88500
gttctccgga agaacttgca cgatcctgcg tgatatgggc atcgacacgc ttgtgcgagt 88560
cattaaacga tctcctgaac acgaggatgt acgtaccata caccaactac gtggaacatt 88620
ttttgacgaa ctagcactac gattacaatg tgggcataac atctgtatat tttcatcaac 88680
tttatcgttt tcggagctag ttgctcagtt ttgtgcaata tttacagact ctattcttat 88740
tttaaactca actcggcccc tatgtaatgt aaacgaatgg aaacattttc gcgtgttggt 88800
gtacactacc gtcgtgaccg ttggattgag ttttgacatg gctcattttc atagcatgtt 88860
tgcttacata aagccaatgt catatgggcc ggatatggta tcggtctacc agtcattagg 88920
gcgtgtacgt ttattgctac ttaatgaagt tttgatgtac gtcgatggct caaggaccag 88980
atgcggaccc ctgttctcgc caatgttact aaactttacc atcgcaaata aatttcaatg 89040
gtttcctaca cacacccaaa taactaacaa actgtgctgt gcatttaggc aacgatgtgc 89100
aaatgcattt acacgctcga acacccatct cttctcaaga tttaaataca aacacctttt 89160
cgagagatgc tctctttgga gtttagccga tagcattaat atcttacaaa ctcttttggc 89220
ctctaaccaa attttggttg tattggatgg catgggtcca ataacggacg tttccccagt 89280
tcaattttgt gcatttatac acgatctcag acatagcgct aacgccgtag cttcctgtat 89340
gcgttctctt agacaggaca atgacagctg cttgaccgat tttggccctt ccggatttat 89400
ggccgataac attaccgcgt ttatggaaaa gtatcttatg gagtcaatta ataccgaaga 89460
acaaattaaa gtatttaaag cccttgcatg tccaatagaa cagcctagac tagtcaatac 89520
ggcaatattg ggggcgtgta tacgaatacc tgaagcgttg gaagcatttg acgtatttca 89580
aaaaatatac acgcactacg cttccggttg gtttcccgtc ctggacaaaa ccggggaatt 89640
tagcatcgcg actataacta ccgccccaaa tttaaccacr cattgggagc tgtttcgccg 89700
ttgtgcctat attgcaaaaa cactcaagtg gaatccgtcc accgaaggct gtgtaacaca 89760
agttttggat acggacatta atacactttt caatcaacac ggggattcgc tggctcaact 89820
aatatttgag gttatgcgct gtaacgttac cgacgctaag attatattaa accgcccggt 89880
ttggcgaaca accggattct tagatggatg ccataatcaa tgcttccgtc caatccctac 89940
aaaacacgaa tataacattg ctctatttcg tttaatttgg gaacaattat ttggcgcccg 90000
cgtaactaaa agtacccaga cctttccggg aagtactcgt gtgaaaaacc taaaaaaaaa 90060
agatctagaa actttacttg attcaattaa cgtggatcgt tctgcatgtc gtacctaccg 90120
ccagttgtat aacctgctta tgagccatcg ccattcgttc tcccaacagc gttacaaaat 90180
tactgccccc gcttgggcac gccacgtgta ttttcaagca catcaaatgc acttggcccc 90240
gcatgccgaa gccatgctac aattagcgct atcggaactg tccccgggat cgtggccgcg 90300
gataaacggg gcggtaaatt ttgaaagttt ataacccatt aataccatat atggacatcc 90360
ataggggggg ttacataaat actaagcctc tgtacaacac aaagggcctc taacaatgca 90420
ctgaaccaca accaagctat ggacgcaacg cagattacct tggttagaga aagcggacac 90480
rtttgtgccg caagcatata cacatcctgg acacagtccg gacaattaac acagaacggt 90540
ctttccgtgt tatactactt attatgcaaa aactcatgtg ggaaatacgt ccctaagttt 90600
gccgaaatta ccgtacaaca agaggattta tgtcgctact ccaggcatgg ggggagtgtt 90660
tctgcggcaa cgtttgcgtc tatctgcagg gcggcgtcct cggctgcgtt agacgcctgg 90720
ccccttgaac cactgggtaa cgcagacacc tggcgttgtc tccatggcac tgccctggcc 90780
actttacggc gcgtattagg gtttaaatcg ttttattcgc cagtaacatt cgagactgat 90840
acgaatacag gtcttctgtt aaaaacaatc cccgatgaac acgcgttgaa taatgacaac 90900
acgccatcta ccggagtatt gagggctaat tttcccgtgg ccattgatgt ttcagcagtc 90960
agcgcatgta acgcccacac gcaaggtacg tcgctagcct acgcccgcct gaccgcactt 91020
aaatctaacg gtgacaccca gcaacaaaca cctttagacg tggaggtaat tacaccaaag 91080
gcctacatac gtcggaaata taagtctacg ttttcccccc ctatagagcg ggaaggtcaa 91140
acctccgatt tgtttaacct tgaagaacgc cgcttggttc ttagtggcaa tcgcgcaatt 91200
gtggtaaggg tactcttacc gtgttatttt gactgtttaa caacggattc caccgttaca 91260
tcttcccttt caatattagc aacatataga ctgtggtacg cggcggcgtt tggaaaaccc 91320
ggggttgtcc gtccaatctt tgcgtattta ggcccggaac tcaatccgaa gggtgaagac 91380
agagactact tttgtactgt cggatttccc ggatggacca ctcttcggac acaaactcca 91440
gccgtcgaat ctattcgcac ggctacggag atgtacatgg aaacggatgg gttgtggcca 91500
gtaaccggta ttcaggcctt tcattatcta gccccctggg gacagcatcc ccccttacct 91560
ccgcgggtgc aggatcttat tgggcaaatc cctcaagata ctggacatgc agatgcaact 91620
gtcaattggg acgcgggccg gatatctacc gtcttcaaac agcctgtaca actacaagat 91680
cgttggatgg caaagtttga tttcagcgcc ttttttccca cgatatactg cgctatgttc 91740
cccatgcatt ttagattagg caaaatcgtc ctggctagaa tgcgtcgagg aatggggtgc 91800
ctaaaacccg cgttggtgtc tttttttggg gggttacggc acatactccc gagtatatac 91860
aaagctatta tttttatagc caatgaaatt agcctttgcg tcgaacaaac ggccttggaa 91920
cagggctttg ctatatgtac ttatataaaa gatggatttt ggggaatctt cgccgattta 91980
catacgcgca atgtatgttc agatcaggca cgttgttcgg ccttaaattt agcggccgcc 92040
tgcgaaagag cagtcacggg cttattacga attcaactag gtcttaactt tacacccgcc 92100
atggaaccgg tactccgggt cgagggtgtg tacactcacg catttacctg gtgtaccacg 92160
ggaagctggc tgtggaattt acaaacaaac acgcctccgg atttagttgg cgtgccatgg 92220
cgaagtcagg cggcgcgaga tttaaaggag cgtctttcag gactcctatg taccgcaaca 92280
aaaattcgag aacggataca ggaaaattgc atatgggacc gtgtcctata cgacatatgg 92340
gccggacaag ttgtggaggc tgccagaaaa acatacgtcg atttttttga acatgttttt 92400
gatcgccgtt atactccggt atactggagt cttcaggagc aaaattcgga aacaaaagca 92460
ataccggcat cttatctgac atacggacac atgcaagata aggattataa accaagacag 92520
ataattatgg ttcgtaatcc caacccacat ggacctccta ctgttgttta ctgggaattg 92580
ctaccatcgt gtgcctgtat tccccccata gactgcgctg ctcatctcaa gccccttata 92640
cacacgtttg tcactattat taaccatctt ctagatgctc ataatgattt ttcaagtcca 92700
tcattgaaat ttactgacga tccccttgct tcatataact tcttgttttt atgacaaaaa 92760
aacacgccgc aacaacccat ccttaaaata aaaggtttat ttactttaca acccgtggtg 92820
aatttttata cgtttcaaat aactgaacat ttttcggtgt taccatggtg cgatttaacc 92880
accaaaaata tacgctcttc tgatattccg aatctcgtaa aggtccattt aacaatcccg 92940
ggggcacttg caccacacca tctggacagg ggggggttcc gtggggcagg tcaaaacgct 93000
gacccacccc acatgaatat atagccttta taatattggg ggccgttcca ggctgagggt 93060
tcagtaactt aacaaacata taatgcggca atacgcgggt ttttgtaaag gggttgttat 93120
caacgacata cattagagtg tttaacaacc ataaaactcc ctcatataaa aaccgacgca 93180
ttttttccaa aggtcctatt tgacactcaa cgcgtctaag atatacagac aattgtacaa 93240
acagcgatgg agatgccccg gagggcccaa tgccttccag atacattaaa ataacacata 93300
aggtaaaatc taggacatta tccgggcgga atagagtcat ccgatagatt aacaggcgcg 93360
gaggcacccc caccgtatac accctatctt caaccgcagt taatacggaa aaaataaatc 93420
cgcggaacgc tggttgagta acacactcca tgtagtaacg atcacaggac acctcacttg 93480
aatcaccatt caacactact aaaacggtct cttggtgttc cggttttacg cgcagtgata 93540
caacagagtt tgccaaaaag cgtggcttca aaccggttac ctcccgcgcc tcgcatacga 93600
atcttggtat tgcttgtatt ctaagatctt cgatcacgtc gctcacatcc aacccctctt 93660
cggctcgtgt tagtaagttg tcgatcgtta cgctgcaacc taaaatgctg ggtatattta 93720
ttccggacat cccatcggcc atccccgcgc ctccggtttg ctcgaatttt atccagtaag 93780
gtcgaatccg ctgcatttac cttgtgtacc cgtaacctct caggggggtg tcctttcata 93840
aaatgggata ggtttttata tccaacatgc atgtattggt tatttatttt attgggttcc 93900
gggattcttt cgtcatcttc tgtagggtca ggcaaacccc aggaaggact tggtgttctc 93960
cgtgggcccc gttttattac ctctgcgcga acctgcattt catataatat tcggatttgg 94020
gataaatagg actctgttct cgccttttta aaaatagcct ggcataactc ttcctctgac 94080
ctatgtacct cgctttgagt taccaagaat cccaatcggg tggcccgtaa tatgaatgaa 94140
aaatacggcg caactagtaa tgagattgac gcatttgaat atgatacaga aatttcctgg 94200
ccttgattat tgtttacccg gtgaagctta aaacagcgaa caagttcctg tttccatagc 94260
tcagacaaac gttttatatc atctccataa ggggggatat aacgagattg aaaactattg 94320
gcaatatatg catcatcccc tattatgccg gtaagatcta taacctcgtg atttaaatcg 94380
gcaatacgtg tttcttctgc cattgtaata tgtgaccctt tagatggctt tatttttacc 94440
ctctcttccc gtaaccgttt cagctctcct tctttgaact ggagcctttc ggtcagatcg 94500
ctgttcacat ccttgagacc ctcaatggtt ttgaataaat tattcacata accctcgagc 94560
atgccgttga tactgttgac caccgatgtt ttaaacgcac tttgaacgtt tgttgttccg 94620
gacattgccc ccccgttaaa ggattggttg gccttgccaa accccggttg tgatgtgtcc 94680
accgatccac ttccttccag aatgtgattg cccgtttctt ctagatagga acgtacggtt 94740
tcggtaatat ctccaacatg tctcatgttt tttaagttaa ctattagctt tacaagtcta 94800
gacgcggccg atccagcccg tgttgtatcg ttctcgccca ttatacgatc aaccgcacgt 94860
gtgctgtgag atctatcatc ttcattccgg cgacctatta acacgcgcaa aggggctgta 94920
tttaaaactt ggcagacgcg agcatgttca cgtaatgcat aacaggccaa cacctcccca 94980
gaaagccgct gtaagggtga gtcaaatact acaccctccc cacatacaac gggcggccac 95040
acgaccaaac actctccctt catgcccgtt acatcatcct ttgccataat taatcttcgg 95100
ttataattat aataaagacg cgtcctatca taatccataa tagcaacatt ttgcatacac 95160
tcaactaggc ttgtgacaac cgccgcccct ctggccaacg ttgcatcggc aacttttaac 95220
atctgggaca gttctgccgc ttgacccata tacgtattta atggtgcagg ggttccattc 95280
tgttctgatc gtacctttct tacaacgggc acaataccta cacaggctat ccagtccacg 95340
tatttggcaa aaccgaccct tccatttaaa ccactggtat agagacaacc ggttattcca 95400
cgcagaaact caagtaacga tgactgtaat gtttgacgcc aggtttcaaa aacctgatgt 95460
gcaagccgta cggcttctga ttctccacat aacccataac gttccgctag agccccggca 95520
tgcaggttac attgttggat gtggtggtcc caatctgctg ctaggtcctc ataccgagtt 95580
gcatccaacg cgttcatcaa aacggttgcc tgaacttggc gaattacagt ttccgtagac 95640
cgtacagcgc tatatatgcc ttgtccatcg gtatatccaa agtcaccggc taggattttt 95700
cgaaacaaca tactttgcgt ggttgggtgt attaacatcc agccatcttc ctccggaaat 95760
gtacaaaacc ctatatccgg ggcgtactca ttccagtata tatcgaacat gttcttgtat 95820
tggtcatttg ggttacttcc attcaagccc tggtcaatag aaacagaact tgctatcctt 95880
ttttcttcac taccggaact gttattaaaa agagacgtta tttcggccat tgaaaaccac 95940
gatgaaaaga tcaatttctg tagacagttc ttcacccaaa aacgttttta atccagagac 96000
gcccaatgga tttgatgaca gtgtatattt aaacttcacc tctatgcata gcattcaacc 96060
tatcctctca cggattcgag aacttgccgc aattacgatt ccaaaagaac gtgttccgcg 96120
gttgtgttgg tttaaacagt tactcgaact gcaagcgcct cctgaaatgc agaggaatga 96180
gctccccttc tccgtttatt taattagcgg aaatgccggc tccggaaaaa gcacgtgtat 96240
ccaaacgctt aacgaagcta tcgattgcat tattaccgga tccaccaggg ttgctgccca 96300
aaatgttcat gctaagttat caacggctta tgcgagtcgt ccgataaaca caatctttca 96360
tgaatttggt tttcgcggaa atcacattca ggctcagctg ggccgttacg catataactg 96420
gactacgacc cccccttcta ttgaggacct gcaaaaaaga gatattgtat actactggga 96480
agttttaatt gatataacaa aacgagtgtt tcaaatgggg gacgacggtc gcggaggaac 96540
atcgacattt aaaaccctgt gggcaattga acgtttgctt aataaaccta caggctcaat 96600
gtccggaacc gcgtttatcg catgcggttc ccttccggct tttacccgga gcaacgttat 96660
tgttattgat gaagcaggat tgctagggcg tcatattctc acggccgttg tttactgttg 96720
gtggcttttg aatgctatat atcaaagccc tcagtacata aacggtcgaa aaccggtcat 96780
agtatgcgtc ggttcgccca cccaaactga ctcgttagaa tctcattttc aacatgacat 96840
gcagcgttca cacgtaactc ctagtgaaaa tatactcacg tatataatct gcaatcaaac 96900
tctgcgtcaa tatactaaca tctcacataa ctgggcaatc tttattaata acaaacgatg 96960
tcaagaggac gattttggaa atcttttaaa aacgcttgag tacgggctac ctattaccga 97020
agcacatgcg cgtctggtcg atacatttgt tgtacctgca tcctatatta acaatcctgc 97080
taatctcccc ggatggacgc gtctgtattc gtcgcataag gaggtgagcg cgtatatgag 97140
taagttacac gcgcatttaa aactatcgaa aaatgaccat ttttctgtgt ttgccttacc 97200
gacttataca ttcatccggc taacggcatt tgatgaatac cgcaaattaa cgggacaacc 97260
cggactttct gttgaacatt ggatacgggc aaactccggt cgtttgcaca attattccca 97320
aagccgagat catgacatgg gaacagttaa atacgaaaca cattcaaatc gcgacttaat 97380
tgtagcccgt acagacatca cttacgtgct aaatagtctc gtagttgtaa ccacaagact 97440
acgtaagtta gttattggat tcagtggtac atttcaatcg tttgcaaagg ttttacgtga 97500
cgactccttt gtgaaggctc gaggagagac atccattgaa tatgcttacc ggtttctgtc 97560
aaacctaatc tttggaggct tgattaactt ttacaatttt ttgttaaata aaaacctaca 97620
tcccgataag gtatcgttag catacaaacg gttagctgcc ttaaccctgg agttattgtc 97680
tggaacaaac aaarccccct tacacgaagc agcggttaat ggggcgggtg ccgggattga 97740
cygtgatggt gcagctactt ctgccgataa agccttctgc tttaccaaag cccccgagtc 97800
caaagtaacg gcctccatac ccgaagaccc ggatgatgta atttttacgg cacttaacga 97860
cgaggttatt gacttggtat actgccagta cgaattttcc tatcccaaat catccaatga 97920
ggtccatgct cagtttctgt taatgaaagc tatttacgat ggtcgatatg ccatattagc 97980
agagcttttc gaaagcagct ttacaaccgc cccctttagc gcgtatgtcg ataatgttaa 98040
tttcaacgga agcgagcttt tgatcggcaa tgtgcggggg gggctgttat ctttggcatt 98100
acaaacagat acgtataccc ttttggggta tacttttgca cccgtgccag tctttgtaga 98160
ggaactgacc cgaaaaaagc tgtaccgcga aactaccgaa atgttatatg ctctacacgt 98220
acctcttatg gtcttacagg atcaacatgg gtttgtgtcc atcgtaaacg ctaacgtatg 98280
tgaatttacc gagtctatag aggatgcaga attggcaatg gccaccacgg tggactatgg 98340
ccttagttct aaactagcca tgacaattgc acgctcacag ggcctgagtt tagagaaggt 98400
agctatctgt tttacggcgg ataaactgcg cctaaatagt gtgtatgttg ccatgtcgcg 98460
tacggtctcc tctaggttct taaaaatgaa tctaaaccct ctacgggaac gatatgaaaa 98520
atccgcagaa attagcgatc acattcttgc cgctctacgt gatcccaacg tacacgttgt 98580
gtattaaagc attgtataaa aacacgcatg cgggcttgct gttctcattt ctaggttttg 98640
tcttaaatac acccgccatg agcatctctg gacccccaac gacgtttatt ttatataggt 98700
tacatggggt caggcgggtt cttcactgga ctttaccgga tcatgaacaa accctctacg 98760
catttacggg tgggtcaaga tcaatggcgg tgaagacgga cgctcgatgt gatacaatga 98820
gcggtggtat gatcgtcctt caacacaccc atacagtgac cctgctaacc atagactgtt 98880
ctactgactt ttcatcatac gcatttacgc accgggattt ccacttacag gacaaacccc 98940
acgcaacatt tgcgatgccg tttatgtcct gggtcggttc tgacccaaca tctcagctgt 99000
acagtaatgt ggggggggta ctatccgtaa taacggaaga tgacctatcc atgtgtatct 99060
caattgttat atacggttta cgggtaaaca gacctgacga tcagaccaca ccaacaccaa 99120
ccccgcacca gtatacatcg caaaggcggc agcctgaaac caactgtcct tcaccacaac 99180
cggccttttt cacatcagac gacgacgttc tttcgttaat attacgggac gccgcaaacg 99240
cgtaaagaca gattcaagac taacatttat cccaactgat tacatttcat acgcgaataa 99300
acgacacaaa aaatttatat ttaacggctt ttaatttgaa gacacctatc ctcttaacgt 99360
tgaggagcct tgcaggttgg gtgccgcgct tcaccggtat tatacataac cgatttaccg 99420
tgtttacggc agtctgacca tttaccagtg tatgtctgta atacgacgtt gttgtgtccc 99480
gacaaaatta actcgcgtac aaatttctga tgttcccccg gcgtggcaac gctggcattt 99540
ccaaacacat tacgttctcg tacgtccatg accgctattt tcagtattaa ttggttggtc 99600
ggtcaaagta ttttccttat gtaaaaggac acgatctaaa gccgtaaact cgtacacaaa 99660
cactggtacc aacggacgcg attttccgtc cgttgagcgg gtgtaatatc ggcgaggtct 99720
tcttgcacga atactctcgt acagtaggtt tctgacacgg ggtgcatggg ttttttgaca 99780
caacacaaac atttgcaggc tcttatgact ggatggattg aatttatttt tagatagggt 99840
cacgtgtttt tgtcgtgaca cgcctcgacc agaaaaggct gcggttttcg tacacgcgac 99900
cgttatttca caggcgttca taatcaagct gcggcggatg gtgtcggtta attgtctccg 99960
cccaagttcg tcaatagatg ataccatgaa caacgtatca aatggtacat agtcgtcttt 100020
ggttttctca atacagcccg cgtgcccaat cggaaaattt tcatttgcat caacgctatt 100080
ttctgtaaaa tcggtctgaa cactgtgttg gctggctacc tgtttaaaat ttgggatcga 100140
acacggtcca cgatgcaatc cccaacccca ttgaagcaat gccgtcggta cggaaggagg 100200
caactccgaa aacattatgg tacgcgagag ggtcgattgg agtgttatat aacactccaa 100260
tcgatctcgg gttcgccttt acgcgtaaaa tactcattgg cttgaacgaa atgtcgacaa 100320
ttccgaaatg gaacacggga caatggcgac ggatgcgcgt gtgttagcac cagatgacat 100380
cttgaattcg gttgggttgt cttctgtgca tgcgcacccc acagcataaa aactaaccct 100440
gtacggttct cgcataacct ctgtagcacg cgttgcacca gccgccccca gcctaagtat 100500
acatgcgacc ccggagtccc gcgacgaacc gtaagcgtgg tattcagcaa taacaccccc 100560
tgccttgccc aactctccag gcatccgtga gtgggcggag tcatatttgg gtatgattcc 100620
atgagggccg caaaaatatt tttaagacta gacggtggtg ttatgccacg ttttacacta 100680
aacgctagcc catgtgcatg tcccgcggta gggtatggat cttgaccaat aattacaacg 100740
cgaatgctct ggggtccgca aaatcgcgtc catgcaaaaa tatcgcctgt agatggaagt 100800
atttcttccc ctgaatttaa aagacgattg tattctaaaa aaataccttt cgcgtacggc 100860
tctttaagtt cgtccgacaa caggtcatac cactcagggg aaatgttaaa cttgctgaaa 100920
acttcaaccg aatccagttg cgaagagacg ggggtgaacg tttccgtgtc gtaatgatgt 100980
gacatgttat ttaacttgaa ggttgggggg tctagcttaa cccccaaagg crgcccgcgg 101040
ggtcgcttgc gggttttttt ggtaaccgga tgggccaaaa cataaatgtc ctttgaatcc 101100
gatagtttca tttcattggc atacgcgttg gaacaaacgg tcggctcccc agacacatcc 101160
attttccggg atatttgtgg aagatggagt agagtctacc catacaccgg aaagggcatc 101220
caacaaagca tcgcgtatgt ccccgctttt atgttcttca ccaacagatt gtgtcagccc 101280
ctttaaggtg acgtatggat ttgtccagta cgccatttgt ttgtctttaa accaaagtat 101340
aacttccggt actggacatt ttgtcttaac cacgattccc gatagcgcct cgctgaggtt 101400
tgataccggg ggtgccgcat agtcccacgc ctcatatacc gatgacacgc acggttccgt 101460
tataatcaaa ctcacatccg atagcggttt ggctccaaaa aacaacggag tgtcgtcttg 101520
gagatgaaga caatacgcga ttgtgatagt ttttaaaaaa actatcatct gcagtaacca 101580
tttatgtgat gccatgacgc ttgtgttttc ccttcactac gacgttgtcg tatcctttga 101640
aaaacttgac cactctaatg gaagcatgga caagtatgag ttttatatat acagttggcc 101700
tttagttaaa ctcttggtgt catatctcat tttcctaaaa agggcgatct taatatgtca 101760
aacgtcacgg cgtgccgaca aagcgaattt ccatgcaaga tttggatgta gtatttatac 101820
acccaatcac acgtcacgta ttaagcttta cagtcccccg ttatctgata taatcacttt 101880
tcttaacacg tcatcgggaa aacagatgtt tatattatac ctctcgcggt catttatggc 101940
aaatacttag accgttttca agcggactga aaacgctcaa attgcctttt ggaggcctgc 102000
ccaacggcca ttatcccttg gatctaagat tgatttgcgg taacgtttgc caatcaagct 102060
ttaaaaacgt accccaaact taaaacgctc aaattgcctt ttggaggcct gcccaacggc 102120
cattatccct tggatctaag attgatttgc ggtaacgttt gccaatcaag ctttaaaaac 102180
gtaccccaaa cttaaaacgc tcaaattgcc ttttggaggc ctgcccaacg gccattatcc 102240
cttggatcta agattgattt gcggtaacgt ttgccaaacc cacgcatttc agtttaaata 102300
tttctaagca ttcttagtgc gtacttggca gcgtgcttaa aatatcaacc aatatccatt 102360
atgctaaacg tttccttcta tccgtttcaa tccattaaaa gtccattacc aaaaatgatg 102420
catcatacct aattcaccta aaaacctgac tcattgcagc agcgtttcct ccttgcagac 102480
tatccagttg gcattttaaa cgggtccggc tgcctgaacc gaaaacaccg ttgcctttac 102540
tgtaagtaca aaactaaaat ttatatttgc gtgcgtattt tgtaacatat atgcctttta 102600
tccccccgca agtttgcttt accctcgcct tcaccacccc cgccaccttc cggccattgt 102660
aataacttta attgctataa gacataccca aaccggatga tttttgccgc tggaaaaaca 102720
gcttctaatt ttcccgtctc aactcggcct tggttgcatc tccaagtata cctttagttt 102780
gctcccgtag aggtgtataa atacaaacgg tgacaagtat tgagcgtaat ctcaaatttt 102840
tgtaatttag ggcggagcgc ttacgacagc acatgcgtac tgttagactg ttatgtttat 102900
tgtatttgca gagcaggatg ccccggttac tccgagaccg gattgcgggc attccgaatc 102960
gtgtacggac ttaccagggg gcagtattta caccttgggt tccagatata ccaaccctta 103020
cgaccaatag caacactcag gtatttttaa aatgcacgtt taatgatcat aatttacata 103080
cagttggtaa taaagcagac cgtggatgtt taaggcattt ccttccccct cccaacaaac 103140
taggacttct tcatcttgtt tggaatacct ttacccgctt taccggcaga gctttttttg 103200
gtaaggtgtt tcagtgaacc tgatgttgat ccggaggtgg agggggtatt ggactccccc 103260
tgtggagagg caactttgcg ggttttactt cccttacatg ccgaatcaga ctcagatgtc 103320
aggtctattg ttaagcatcg tttaacgtct ctgccggtat gaaataaacg gcgcttagca 103380
ccccttgcgc ttcccggttt aatccccggt aacacagaaa aaagcctgac tttttggggt 103440
gtatttacca atcgggtatc cctttcatcg ccacgagagg tctccccggt tgaggtggtt 103500
tctggtctta caattggacc tgtaattagt tggatggctg tatctttcca ggtccaggtt 103560
tgcatggtta ggcgggttgg atcggtacat cgatccaaca agaataacat gtttgttaca 103620
aacggtcctg ttgaatcatg caaaagacaa cgcagggatg tttttaatcc cgcctcatca 103680
cgcccgtaaa tacctatata gtttaatatc aacatttttg taggctctac aatttcgggt 103740
tgatacagtt ccgcaagttg atcatcaagc catccgagta aaggttgcat gtaacacggg 103800
aatctcgcgt ttccctctgt tcctctatcc gtggctcgaa aaggcagtct gtccatggtt 103860
cgtgggtctt gattaattcc cacagatact ggacgatcac ggtagtcctg ccccccggtc 103920
cggggttgct gtgcagattc aatcgagcca tacaccaccg gggtcgccga tcgaacagca 103980
ggttggtctt taaaaaatac cttccgtaaa aatgatgcgg tagagcatgt tttggttaca 104040
ccagggctcg agtctcgggt cggtggttgt atagaatcct gttgagagtc acttggtgac 104100
tctgctgtgg gctctctagc cgacgattga aggggcccag ggtttggtga ttgaatgggc 104160
tcccgactcg atcttgatgt tggctgttgg atggactccc gactcggtcc tgggcttggt 104220
ggcagaagat ctatgacatc tcccggtagg atgtcgatgg aatcttcaaa tgacggctca 104280
gaaaaaccat cgtcgtcgga tgggtgcact tcatattcct tgtaacttgt atcacttacg 104340
atcttatgca ggatggattg cactggacac cggcagagag gacactggac gctggtggag 104400
gtccatgccc gaatacaaac aaagcagaag tcgtgcaaac acggcatggt ttttccgaga 104460
tcggaaacgg tgctcatgca tatggtgcag gtattatccg aagcgtcgga ggtgccgcta 104520
ccgcccgcta atatggtatc catggtaaca actggctgta ttctaatgtc cgggcatcca 104580
aacacgtagc agaactgcca tgcgttctaa attgtgagtt gtggcgagta catttttata 104640
attggtacca acgaagacac acccctatat ccctccaccc atttctttta agtcccaccc 104700
actaaaacgt gggtataaaa tgtgtattgg ggtaggcgga cagtcccaac aaacagggaa 104760
gttgattggt ataaccttgg gccgggtata cagctaagtg acattttaga ttctgtcttt 104820
atttagataa agagcgatac gaagacattt ctccaccccc ctgtaatacc cgtaaataaa 104880
ggtaagtcca caaacaaaag cactgtatat aggaagtcgg gtgtattggg acagttactc 104940
cattagaggc gtacagacaa tactgggata gggtaatgca agtccccccc gatggtcgcc 105000
ccgcaaacgc gcggggaggt ggggtcgctt ttttttttct ctctcgaggg ggccgcgaga 105060
gggctgggcc cccccccccg gggtccgccg ggcgcccaga aaccgggggg ggttattttc 105120
ggggggggtc cgaccagccc gcccgtcgcc cgcccgcaca gacagacaga cacttttttc 105180
ataaaaaccg ttccgctttt attaacaaac aacaaacagt ccgcgcgccr gtggcgctca 105240
cgagaaaagg aggggactcc gtcacccccg actctgcggg gggctcctcc ccccgcgccc 105300
tccccacaca tcgtcctcgt cctcggagga cgaggacgag gacaacagct ccaccttgac 105360
cgccgggcgc ragcccaccc ggcggtctcg cagcacaccc ggggccaccg acacgacgct 105420
caccccaaag gatgaccccg gtgcgtcccc gtcgtccccg cccccctcct cgctgtccca 105480
cgcgtcttca caccccacct cccaatcgtc cggctccaaa gcgtgttctc tgtcgtctgc 105540
ggtgcgccgc tgtcgccccg cctgggtttc tgccggccgt tccgagcccc cgtggtgtcc 105600
gaacgcgaac cgtgttccgt cgctcccctc caacaccgtc tccgcggccc caaaaccggg 105660
cggccacatt actctgggaa tcggggggag ggcattccga gcctcgtccg ccgacgcata 105720
cagcgccacc gaccgaccgg ccacgggtgg aagcacgagt ggttccgcgg cagggtcggg 105780
ttccagcagg gcgtggcggc aaaacaccct cgcccaggtg ggtacgtcgc cggcctccgg 105840
cccggcggcc cccggtctcc gtccctcggg aaggaagacg ggtcgaagcg cggcacccag 105900
gccccatcgg tttgctgcgc ggtggctatg tgccgcctcg tccacaaagt cggctgcccc 105960
gagccccaga ccccgagact gtcgcgcgag gtccttgcaa ccgtcaaaac ccggcagcac 106020
gtactgccgg tattcacggg gcgacagggg gacgcgggtc ttggggcccg cgcgggtaca 106080
cacggtgtat gcgacgttcc caccgcggca caaacacagg ggttgttcgc ccgggtacag 106140
gttggcaaac gcagtctcga tacgagcaaa actcgctggc ccaaaggtgc gcgacgatgc 106200
aaacacggcc cgggcgagtc cttctgtgac cgccgagtct ggccatcgga cgacggcctg 106260
ggcgtccggt cgcgccgggg cccggacgta cacgtgatac tgagacaaag cgggtccatc 106320
cccgggccac ctctcgaggg ccaccgcgtc caacaccagc aaccggcgcc gggcagaggc 106380
caaccgcgag cctagatact cgacggcccc ggcaaaggcc aggtctcggg tcgacagtaa 106440
taaaacgccc cgggcgttca aagcggacac gtccggcggg ccggtccagt tcccggccca 106500
ggcatgagtg ctcggcaggc acaaccggtt actcagggct gccaggacca cagacagtcc 106560
ccctcgggat ggactccatg acggtcccgg atctgtcgcg agggtgctct cgagggggcc 106620
gttgatgtcc tctccgggca acggatcgta gatgatcaga agcctcacat cctccgggtc 106680
tgggatctgc cgcatccagg cgcacctccg tcgcagcgcc tccactccgc tgggtggacc 106740
aaaccgtcgg tctcctccgc ccggacgccg agcggcgatt tccgccaagg cgccgggatc 106800
aaagcttagc gcagggcgcc aggccgtggg aaacaatggg tcgtcgacca gacgggcgat 106860
ggtttcgggg gtacagtacg ccttgcgagc ctggtccgac gggaccgggg tatgcagggc 106920
cccccgggga atacgccgaa atcccccgtt tggggccggt ccgtcaagtg gcatcgttat 106980
tacggcgggg ggatccacca cagggcccga ggtgatggtc acgggctcgg atacccgcct 107040
cttggccttg gaaaccacat gatcgtctgc aacccgggcg tccgcgacgg gtgtctccct 107100
aatcttgtcg aggaggcttc tgctctcgac tggctgggac ttgcgcttgc gcggagttcg 107160
taaacgatca tccggtggac acacagaaag agagcgcgcg gcggccgacg gctgagggtc 107220
gggagtctgt gtggccgggg ttgttggaga agggtgaccg cgggagatcc gcgccgccgg 107280
actggagccc gttgcctcgg ggtatgccat gccggcaaag gctctgcgga gactctgtag 107340
gataaagtgt ttttgggccc ggtcgtaccg acggctcata gccacggccg cggccgcgtg 107400
ggggagagcc cagagggcct cccccgtggc catggcttcg cctacatgcg gaacgggaga 107460
cgctacgctc cccgtaacgg cggtacccgc ccgtcccggt ggcaacagct tttggtagaa 107520
ctggttcagg gccgagttga caccggtcag cttggggttc tggagccatg ctatagggtc 107580
tctgtctgga cagtagatca ggttaatcag cgcgcggtac tgtctagccg gatctcccaa 107640
ctccggcacg taaagcggcr cgggttcagt tgaggcctcg taacgagccc gcgccgctct 107700
cacagcctca tcctcccagt gaccctctct ggtctccccg gacggtccaa accgcaccct 107760
gttggatggg aggggcgccg atccgggcca agggcttccg tcgggcatca tgagcggccc 107820
cgacaccggg ggaattatcg gggttctgga tcgcggcagg gaaaatgatt tctgtctctg 107880
gcgccccggt tcccccgcaa gacgtttggt cttacgaatc ctcggatcgg gaccgctgat 107940
ggatcgatat cccggttgga tattttgttt cgtcgaccca ccatcatttg agtccgaatc 108000
atccgaattt gacggggaag gggcgtgttc gegtccggac ctgctgcctg tagtttcact 108060
tcccaccgaa acgcgccggg gttcatcgtc ttcatcctcc gatgacgatc cccacgacga 108120
ggaagaggat gaagacgaaa caaactcacg actctttggc tttttctcca ccgggctgtc 108180
atcctcaatc gggtctggtg cgtgggatct tcccggcagg gccaaaaacg ctctaggttt 108240
gccccccgac gaacgtccag ggacgcgagg tgttataccc cgggcatcat gtttccttgg 108300
gcgggtatca tcggtctcaa acggcaggtc cgcctttgcc cccttagcgg gaacgctgtc 108360
cgaaaggacg tggtacaatt gctcaaccgg gccgggtaca ggtccaccgg gtttccgcgc 108420
cgggagtggg accttaacct tcaaagtctt tttcttcggg ctctttccct gagcgggccg 108480
ttgagttttc tggagaacta ctccgtcccc cgatgcatgc gcatggcccg cttgctcatc 108540
gcccggcttt ttacccgaga tggactgagt ttgtctgtct cgatggacca ccgacggcaa 108600
acctggtgaa tttcctctcg tcgtttgtcg gggtatagac cgctggtctt cccgttgatc 108660
gttcccggcg gcgtctccaa caggagacgc gggggataca ggggagaagg cctgcgggaa 108720
cggaggggtc gtacctctgc ccgtttcccc atcgttcatc ggtggttttg gagacctagc 108780
aagcttcgtt ccgagagaga ctgtctcgag ggagcgatcg gctcctgttg gttctcgcgc 108840
gccggcctcc gagaatcggg tgtggaagac ctcggccagc gggattacag gcgagcccrt 108900
tagatcctga ccgtcctcgc atacgtagtc gtcttgtgtt agctcttcgc caacatcttc 108960
cgttctgggt tctggttgaa gtcccgatac ggagggaatt gaaacgatct catgttcccg 109020
tcccaccatg accccgttct ctccaaatag tagatcgtca ggctgactcg aggtgaccac 109080
ccgggccctg tgttcggcgg ccgcggcggc cgcgtccaac aggtccatta actccaaagt 109140
atcaggcgac cccgcgcgtt ggggtgtaga gcgctgcatc ggcggcgtat ccatcgcrct 109200
ggggtgaatt tagacgtacc cgagttttcc aaacgctctc gcagccttca aaggattgcg 109260
rttgcggttg gtgagggagt tccaacagta cttaaaacgt gttgtgcccc cccctcgacc 109320
gcatatttcc tccccgtgtc gtcaccgtgt aaatattctt aatgataaga cgatgtagtg 109380
attggacgag actcgaggcg ggaagttcat ggaccatagt atgcgtttaa ggagagaccg 109440
ctggttggcg atgtacgccc ggtgtctatt tccgcatacc ttacaacatc ataacaaggg 109500
ataccagaca tgtgaatttc atttacatat gtttaaataa caaccaatca tcgtgtgtct 109560
acagacgata tataatatac ataaacacaa ttggggttgt ctcacatgca aaacatctta 109620
tataacacgg gttgtttcca cccatccggc atctagttaa tcaaatgcac gtcgacggtg 109680
tgtttgggtc cctctccgtc gtcattacgt tcgctcaatc aacaagcgta tacaccacca 109740
cccctcccaa cgattatcat gtcaggcggc acgaagcccg cgataaccca taaaatacac 109800
acggggttgt ggtgttcacg taaccccccg ccgatgggga gggggcgcgg taccccgccg 109860
atggggaggg ggcgcggtac cccgccgatg gggagggggc gcggtacccc gccgatgggg 109920
agggggcgcg gtaccccgcc gatggggagg gggcgcggta ccccgccgat ggggaggggg 109980
cgcggtaccc cgccgatggg gagggggcgc ggtaccccgc cgatggggag ggggcgcggt 110040
accccgccga tggggagggg gcgcggtacc ccgccgatgt ttataaccat aattctctaa 110100
accgttgtag aaaatcacaa aaaaatttat tcaaaaacaa gtcgaagaac ttcatatctg 110160
aggcatgtaa acccattcgc acttcctggg gtggaatggg gtggggtggg ggggtgaaaa 110220
aggggggggt taaattgggc gtccgcatgt ctgtggtgta cgccaatcgg atacactctt 110280
ttaatctgca ttcgcacttc ccgttttttc actgtatggg ttttcatgtt ttggcatgtg 110340
tccaaccacc gttcgcactt tctttctata tatatatata tatagagaga gagagagaga 110400
gagggagaga gtttcttgtt cgcgcgtgtt cccgcgatgt cgcggtttta tggggtgtgg 110460
gcgggctttt cacagaatat atatattcca aatggagcgg caggcttttt aaaatcgatt 110520
tgacgtgata aaaaaaaaca cacgggcccc cccttttttt ggtgttataa aggcaaccca 110580
atcgaaggtc tcccgccccg gaatccccca ttgccatttt acccaagtag ccttattcat 110640
agatgtaaac gtttgggtgt gtgttttgtt gtgcagggtt cgtccgattc ataacgcgac 110700
agcgtcgagt cggttttaag ggaaaaggtt actacggccc caaggacatg ttttgcacct 110760
caccggctac gcggggcgac tcgtccgagt caaaacccgg ggcatcggtt gatgttaacg 110820
gaaagatgga atatggatct gcaccaggac ccctgaacgg ccgggatacg tcgcggggcc 110880
ccggcgcgtt ttgtactccg ggttgggaga tccacccggc caggctcgtt gaggacatca 110940
accgtgtttt tttatgtatt gcacagtcgt cgggacgcgt cacgcgagat tcacgaagat 111000
tgcggcgcat atgcctcgac ttttatctaa tgggtcgcac cagacagcgt cccacgttag 111060
cgtgctggga ggaattgtta cagcttcaac ccacccagac gcagtgctta cgcgctactt 111120
taatggaagt gtcccatcga ccccctcggg gggaagacgg gttcattgag gcgccgaatg 111180
ttcctttgca taggagcgca ctggaatgtg acgtatctga tgatggtggt gaagacgata 111240
gcgacgatga tgggtctacg ccatcggatg taattgaatt tcgggattcc gacgcggaat 111300
catcggacgg ggaagacttt atagtggaag aagaatcaga ggagagcacc gattcttgtg 111360
aaccagacgg ggtacccggc gattgttatc gagacgggga tgggtgcaac accccgtccc 111420
caaagagacc ccagcgtgcc atcgagcgat acgcgggtgc agaaaccgcg gaatatacgg 111480
ccgcgaaagc gctcaccgcg ttgggcgagg ggggtgtaga ttggaagcga cgtcgacacg 111540
aagccccgcg ccggcatgat ataccgcccc cccatggcgt gtagtcttta taaataaata 111600
caatggtttg gctcgtgtct ttttttgatg tctgtctgtg ggggagtggg gtgttgtgga 111660
tattagaggg tagagggtgc tggtttgaac gtctccatta acccacgggg tccccacacg 111720
ggccgtgtgg tatgaatctc tgcggatccc gcggtgagca cccgggcggt gaatatgccg 111780
gactttactg cacacgacac gatacccccg cgcaccrggc tctcatgaac gacgccgaac 111840
ggtacttcgc cgccgcgcta tgcgccatat ctaccgaggc ctacgaggct tttatacaca 111900
gcccctccga gagaccgtgc gcgagtttgt gggggagggc aaaggacgcc ttcggacgga 111960
tgtgcgggga gctcgcagcg gatagacaac gtccaccctc ggttccgccg atccgcagag 112020
cggtgttatc gttattacgc gagcaatgca tgccggatcc acaatcgcat ctggagctca 112080
gcgagcggct gatattgatg gcatattggt gctgtttggg acacgccgga cttccgacta 112140
ttggattgtc gcccgataat aaatgcatcc gcgccgaatt atatgaccgc cccgggggaa 112200
tttgtcacag gctttttgac gcgtacctgg gctgcgggtc ccttggagtc ccaagaaccc 112260
acgagagatc ctgacacccc atccctttat atagaaaaaa aaataaattt aaaacataca 112320
ccggataaaa gcgtactgtt ttttatttaa atttacacgc tcgacgttgc cccggttcgg 112380
tgatcaccgg gtcttatcta tatacaccgt gtaactcgaa cccccgtgac tccctccaat 112440
cgcgttacca aactcttctt ccgtatccgt agattccgag tcctcgaaat cgtccactta 112500
tccaacaaat tgtgacgtta tatatcccaa ggcaaaggcc gctcccgtca tagcaaatac 112560
aaagacaatt attagcgtaa tataacagaa ttttttacga tgatatattt tatgttgata 112620
ttttccaatt cgacgcaaaa attcatctgc cgtttcattt tcgctatcac tataataaca 112680
cttttcagcc gaacggctcg gttgtatggc tgttatcgtt gtattatttg gttgcgctcg 112740
cggggttacc accgcttcca tcagtaaggc cacggcctca ccctccatgg tgttttgtcc 112800
ggccatagaa atccagattg taaggccagc aggctagttt aaaagtgttt aataccacac 112860
cttttgatat ttatatacat gcaagattct agattattca tcaataggtc gtttaaagcg 112920
cgttttcata aacgttgtca gctataccga cattctcaca aagaggtaaa gttaccttac 112980
gttattatta aataaaacat gtagacatta ttaataatcc taggaacaat caaatccata 113040
tttgtaagtt atgtttaacc cctccccttt ttgtcattat ctccgccctc ttataatcgg 113100
atcactttat aagtgtgtcg gtgagtatat tttgtacagt tgttggacaa caggtttttg 113160
gttcattaac actatcaaca taagtcgggg tatacaagta taatgaacga cgttgatgca 113220
acagacacct ttgttggaca aggaaagttc cgtggcgcca tctcaacatc accgtcacat 113280
attatgcaaa catgtgggtt tatacaacag atgtttccag ttgaaatgtc gcccggcata 113340
gaatctgagg atgatcccaa ttatgacgtt aacatggata tacagtcttt taatatattt 113400
gatggtgtac acgaaactga agccgaagcc tctgtggcat tgtgcgcaga agcacgcgtt 113460
ggaattaata aagcgggatt tgtaatatta aaaacgttta caccaggggc ggaaggtttt 113520
gcgtttgcgt gtatggacag taaaacatgt gaacatgtgg tcattaaagc gggtcaacgt 113580
caaggaacgg ccaccgaggc aaccgtgtta agagcgttaa cccacccatc cgttgtacag 113640
cttaaaggaa cgtttacgta taacaaaatg acatgtctta tattaccacg ttaccgaaca 113700
gatttatact gctatctagc tgcaaagcgc aacctcccca tatgtgacat tttagcaatt 113760
cagcgatctg tattacgcgc gttacagtat cttcataata acagtattat tcaccgtgat 113820
ataaaatctg aaaatatatt tattaaccac ccaggtgatg tttgtgtggg agactttgga 113880
gcagcgtgtt tccccgtgga tattaatgcc aacaggtatt atggctgggc tggaacaatc 113940
gccacaaact ctcctgagtt attggctaga gatccatatg gacctgccgt ggacatatgg 114000
agtgccggga ttgtattatt tgaaatggct acaggacaga actcgttatt tgaacgagac 114060
ggtttagatg gcaattgtga cagtgagcgt caaattaaac ttattatacg acgatctgga 114120
actcatccca atgaatttcc cattaaccct acatcaaatc ttcgtcgaca atacattggt 114180
ttggcaaaac ggtcttctcg aaaacccgga tccaggccat tgtggacaaa tctatatgag 114240
ttgccaattg atttggagta tttgatatgt aagatgttat cgtttgacgc acgtcatcga 114300
ccatcggcag aggtgttgct taaccactct gttttccaaa ctcttcccga tccatatcca 114360
aatccaatgg aagttggaga ttaaaattca ttaagcctgt taataaaata ttgtataaat 114420
tgtgtttata acgtataacc cgttaaggca aatagggtac aaacgcgcaa tgttttgaaa 114480
tactaatata aataacataa ccaatagaaa cttaatacag agtcacgccc cattacaaca 114540
aggataaaac acgggatcat tttcttaaca ttgtagtagc gctgaaaagc gtcccctccc 114600
ccggctcaca gagctgctct tcggtgtagt tgggtatact ggtgcgcctc atttaatcgc 114660
gatgttttta atccaatgtt tgatatcggc cgttatattt tacatacaag tgaccaacgc 114720
tttgatcttc aagggcgacc acgtgagctt gcaagttaac agcagtctca cgtctatcct 114780
tattcccatg caaaatgata attatacaga gataaaagga cagcttgtct ttattggaga 114840
gcaactacct accgggacaa actatagcgg aacactggaa ctgttatacg cggatacggt 114900
ggcgttttgt ttccggtcag tacaagtaat aagatacgac ggatgtcccc ggattagaac 114960
gagcgctttt atttcgtgta ggtacaaaca ttcgtggcat tatggtaact caacggatcg 115020
gatatcaaca gagccggatg ctggtgtaat gttgaaaatt accaaaccgg gaataaatga 115080
tgctggtgtg tatgtacttc ttgttcggtt agaccatagc agatccaccg atggtttcat 115140
tcttggtgta aatgtatata cagcgggctc gcatcacaac attcacgggg ttatctacac 115200
ttctccatct ctacagaatg gatattctac aagagccctt tttcaacaag ctcgtttgtg 115260
tgatttaccc gcgacaccca aagggtccgg tacctccctg tttcaacata tgcttgatct 115320
tcgtgccggt aaatcgttag aggataaccc ttggttacat gaggacgttg ttacgacaga 115380
aactaagtcc gttgttaagg aggggataga aaatcacgta tatccaacgg atatgtccac 115440
gttacccgaa aagtccctta atgatcctcc agaaaatcta cttataatta ttcctatagt 115500
agcgtctgtc atgatcctca ccgccatggt tattgttatt gtaataagcg ttaagcgacg 115560
tagaattaaa aaacatccaa tttatcgccc aaatacaaaa acaagaaggg gcatacaaaa 115620
tgcgacacca gaatccgatg tgatgttgga ggccgccatt gcacaactag caacgattcg 115680
cgaagaatcc cccccacatt ccgttgtaaa cccgtttgtt aaatagaact aattatcccg 115740
gattttatat taaataaact atatgcgttt tatttagcgt tttgattacg cgttgtgata 115800
tgaggggaag gattaagaat ctcctaacta taagttaaca cgcccacatt tgggcgggga 115860
tgttttatga agccttaaag gccgagctgg tatacacgag agcagtccat ggttttagac 115920
ctcgggcgaa ttgcgtggtt ttaagtgact atattccgag ggtcgcctgt aatatgggga 115980
cagttaataa acctgtggtg ggggtattga tggggttcgg aattatcacg ggaacgttgc 116040
gtataacgaa tccggtcaga gcatccgtct tgcgatacga tgattttcac atcgatgaag 116100
acaaactgga tacaaactcc gtatatgagc cttactacca ttcagatcat gcggagtctt 116160
catgggtaaa tcggggagag tcttcgcgaa aagcgtacga tcataactca ccttatatat 116220
ggccacgtaa tgattatgat ggatttttag agaacgcaca cgaacaccat ggggtgtata 116280
atcagggccg tggtatcgat agcggggaac ggttaatgca acccacacaa atgtctgcac 116340
aggaggatct tggggacgat acgggcatcc acgttatccc tacgttaaac ggcgatgaca 116400
gacataaaat tgtaaatgtg gaccaacgtc aatacggtga cgtgtttaaa ggagatctta 116460
atccaaaacc ccaaggccaa agactcattg aggtgtcagt ggaagaaaat cacccgttta 116520
ctttacgcgc accgattcag cggatttatg gagtccggta caccgagact tggagctttt 116580
tgccgtcatt aacctgtacg ggagacgcag cgcccgccat ccagcatata tgtttaaaac 116640
atacaacatg ctttcaagac gtggtggtgg atgtggattg cgcggaaaat actaaagagg 116700
atcagttggc cgaaatcagt taccgttttc aaggtaagaa ggaagcggac caaccgtgga 116760
ttgttgtaaa cacgagcaca ctgtttgatg aactcgaatt agaccccccc gagattgaac 116820
cgggtgtctt gaaagtactt cggacagaaa aacaatactt gggtgtgtac atttggaaca 116880
tgcgcggctc cgatggtacg tctacctacg ccacgttttt ggtcacctgg aaaggggatg 116940
aaaaaacaag aaaccctacg cccgcagtaa ctcctcaacc aagaggggct gagtttcata 117000
tgtggaatta ccactcgcat gtattttcag ttggtgatac gtttagcttg gcaatgcatc 117060
ttcagtataa gatacatgaa gcgccatttg atttgctgtt agagtggttg tatgtcccca 117120
tcgatcctac atgtcaacca atgcggttat attctacgtg tttgtatcat cccaacgcac 117180
cccaatgcct ctctcatatg aattccggtt gtacatttac ctcgccacat ttagcccagc 117240
gtgttgcaag cacagtgtat caaaattgtg aacatgcaga taactacacc gcatattgtc 117300
tgggaatatc tcatatggag cctagctttg gtctaatctt acacgacggg ggcaccacgt 117360
taaagtttgt agatacaccc gagagtttgt cgggattata cgtttttgtg gtgtatttta 117420
acgggcatgt tgaagccgta gcatacactg ttgtatccac agtagatcat tttgtaaacg 117480
caattgaaga gcgtggattt ccgccaacgg ccggtcagcc accggcgact actaaaccca 117540
aggaaattac ccccgtaaac cccggaacgt caccacttct acgatatgcc gcatggaccg 117600
gagggcttgc agcagtagta cttttatgtc tcgtaatatt tttaatctgt acggctaaac 117660
gaatgagggt taaagcctat agggtagaca agtccccgta taaccaaagc atgtattacg 117720
ctggccttcc agtggacgat ttcgaggact cggaatctac ggatacggaa gaagagtttg 117780
gtaacgcgat tggagggagt cacgggggtt cgagttacac ggtgtatata gataagaccc 117840
ggtgatcacc gaaccggggc aacgtcgagc gtgtaaattt aaataaaaaa cagtacgctt 117900
ttatccggtg tatgttttaa atttattttt ttttctatat aaagggatgg ggtgtcagga 117960
tctctcgtgg gttcttggga ctccaaggga cccgcagccc aggtacgcgt caaaaagcct 118020
gtgacaaatt cccccggggc ggtcatataa ttcggcgcgg atgcatttat tatcgggcga 118080
caatccaata gtcggaagtc cggcgtgtcc caaacagcac caatatgcca tcaatatcag 118140
ccgctcgctg agctccagat gcgattgtgg atccggcatg cattgctcgc gtaataacga 118200
taacaccgct ctgcggatcg gcggaaccga gggtggacgt tgtctatccg ctgcgagctc 118260
cccgcacatc cgtccgaagg cgtcctttgc cctcccccac aaactcgcgc acggtctctc 118320
ggaggggctg tgtataaaag cctcgtaggc ctcggtagat atggcgcata gcgcggcggc 118380
gaagtaccgt tcggcgtcgt tcatgagagc ccggtgggcg ggggtatcgt gtcgtgtgca 118440
gtaaagtccg gcatattcac cgcccgggtg ctcaccgcgg gatccgcaga gattcatacc 118500
acacggcccg tgtggggacc ccgtgggtta atggagacgt tcaaaccagc accctctacc 118560
ctctaatatc cacaacaccc cactccccca cagacagaca tcaaaaaaag acacgagcca 118620
aaccattgta tttatttata aagactacac gccatggggg ggcggtatat catgccggcg 118680
cggggcttcg tgtcgacgtc gcttccaatc tacacccccc tcgcccaacg cggtgagcgc 118740
tttcgcggcc gtatattccg cggtttctgc acccgcgtat cgctcgatgg cacgctgggg 118800
tctctttggg gacggggtgt tgcacccatc cccgtctcga taacaatcgc cgggtacccc 118860
gtctggttca caagaatcgg tgctctcctc tgattcttct tccactataa agtcttcccc 118920
gtccgatgat tccgcgtcgg aatcccgaaa ttcaattaca tccgatggcg tagacccatc 118980
atcgtcgcta tcgtcttcac caccatcatc agatacgtca cattccaatg cgctcctatg 119040
caaaggaaca ttcggcgcct caatgaaccc gtcttccccc cgagggggtc gatgggacac 119100
ttccattaaa gtagcgcgta agcactgcgt ctgggtgggt tgaagctgta acaattcctc 119160
ccagcacgct aacgtgggac gctgtctggt gcgacccatt agataaaagt cgaggcatat 119220
gcgccgcaat cttcgtgaat ctcgcgtgac gcgtcccgac gactgtgcaa tacataaaaa 119280
aacacggttg atgtcctcaa cgagcctggc cgggtggatc tcccaacccg gagtacaaaa 119340
cgcgccgggg ccccgcgacg tatcccggcc gttcaggggt cctggtgcag atccatattc 119400
catctttccg ttaacatcaa ccgatgcccc gggttttgac tcggacgagt cgccccgcgt 119460
agccggtgag gtgcaaaaca tgtccttggg gccgtagtaa ccttttccct taaaaccgac 119520
tcgacgctgt cgcgttatga atcggacgaa ccctgcacaa caaaacacac acccaaacgt 119580
ttacatctat gaataaggct acttgggtaa aatggcaatg ggggattccg gggcgggaga 119640
ccttcgattg ggttgccttt ataacaccaa aaaaaggggg ggcccgtgtg ttttttttta 119700
tcacgtcaaa tcgattttaa aaagcctgcc gctccatttg gaatatatat attctgtgaa 119760
aagcccgccc acaccccata aaaccgcgac atcgcgggaa cacgcgcgaa caagaaactc 119820
tctccctctc tctctctctc tctctatata tatatatata tagaaagaaa gtgcgaacgg 119880
tggttggaca catgccaaaa catgaaaacc catacagtga aaaaacggga agtgcgaatg 119940
cagattaaaa gagtgtatcc gattggcgta caccacagac atgcggacgc ccaatttaac 120000
cccccccttt ttcacccccc caccccaccc cattccaccc caggaagtgc gaatgggttt 120060
acatgcctca gatatgaagt tcttcgactt gtttttgaat aaattttttt gtgattttct 120120
acaacggttt agagaattat ggttataaac atcggcgggg taccgcgccc cctccccatc 120180
ggcggggtac cgcgccccct ccccatcggc ggggtaccgc gccccctccc catcggcggg 120240
gtaccgcgcc ccctccccat cggcggggga ccgcgccccc tccccatcgg cggggtaccg 120300
cgccccctcc ccatcggcgg ggtaccgcgc cccctcccca tcggcggggt accgcgcccc 120360
ctccccatcg gcggggtacc gcgccccctc cccatcggcg gggggttacg tgaacaccac 120420
aaccccgtgt gtattttatg ggttatcgcg ggcttcgtgc cgcctgacat gataatcgtt 120480
gggaggggtg gtggtgtata cgcttgttga ttgagcgaac gtaatgacga cggagaggga 120540
cccaaacaca ccgtcgacgt gcatttgatt aactagatgc cggatgggtg gaaacaaccc 120600
gtgttatata agatgttttg catgtgagac aaccccaatt gtgtttatgt atattatata 120660
tcgtctgtag acacacgatg attggttgtt atttaaacat atgtaaatga aattcacatg 120720
tctggtatcc cttgttatga tgttgtaagg tatgcggaaa tagacaccgg gcgtacatcg 120780
ccaaccagcg gtctctcctt aaacgcatac tatggtccat gaacttcccg cctcgagtct 120840
cgtccaatca ctacatcgtc ttatcattaa gaatatttac acggtgacga cacggggagg 120900
aaatatgcgg tcgagggggg ggcacaacac gttttaagta ctgttggaac tccctcacca 120960
accgcaaycg caatcctttg aaggctgcga gagcgtttgg aaaactcggg tacgtctaaa 121020
ttcaccccag ygcgatggat acgccgccga tgcagcgctc tacaccccaa cgcgcggggt 121080
cgcctgatac tttggagtta atggacctgt tggacgcggc cgccgcggcc gccgaacaca 121140
gggcccgggt ggtcacctcg agtcagcctg acgatctact atttggagag aacggggtca 121200
tggtgggacg ggaacatgag atcgtttcaa ttccctccgt atcgggactt caaccagaac 121260
ccagaacgga agatgttggc gaagagctaa cacaagacga ctacgtatgc gaggacggtc 121320
aggatctaay gggctcgcct gtaatcccgc tggccgaggt cttccacacc cgattctcgg 121380
aggccggcgc gcgagaacca acaggagccg atcgctccct cgagacagtc tctctcggaa 121440
csaagcttgc taggtctcca aaaccaccga tgaacgatgg ggaaacgggc agaggtacga 121500
cccctccgtt cccgcaggcc ttctcccctg tatcccccgc gtctcctgtt ggagacgccg 121560
ccgggaacga tcaacgggaa gaccagcggt ctataccccg acaaacgacg agaggaaatt 121620
caccaggttt gccgtcggtg gtccatcgag acagacaaac tcagtccatc tcgggtaaaa 121680
agccgggcga tgagcasgcg ggtcatgcgc atgcatcggg ggacggagta gttctccaga 121740
aaactcaacg gcccgctcag ggaaagagcc cgaagaaaaa gactttgaag gttaaggtcc 121800
cactcccggc gcggaaaccc ggtggacctg tacccggccc ggttgagcaa ttgtaccacg 121860
tcctttcgga cagcgttccc gctaaggggg caaaggcgga cctgccgttt gagaccgatg 121920
atacccgccc aaggaaacat gatgcccggg gtataacacc tcgcgtccct ggacgttcgt 121980
cggggggcaa acctagagcg tttttggccc tgccgggaag atcccacgca ccagacccga 122040
ttgaggatga cagcccggtg gagaaaaagc caaagagtcg tgagtttgtt tcgtcttcat 122100
cctcttcctc gtcgtgggga tcgtcatcgg aggatgaasa cgatgaaccc cggcgcgttt 122160
cggtgggaag tgaaactaca ggcagcaggt ccggacgcga acacgcccct tccccgtcaa 122220
attcggatga ttcggactca aatgatggtg ggtcgacgaa acaaaatatc caaccgggat 122280
atcgatccat cagcggtccc gatccgagga ttcgtaagac caaacgtctt gcgggggaac 122340
cggggcgcca gagacagaaa tcattttccc tgccgcgatc cagaaccccg ataattcccc 122400
cggtgtcggg gccgctcatg atgcccgacg gaagcccttg gcccggatcg gcgcccctcc 122460
catccaacag ggtgcggttt ggaccgtccg gggagaccag agagggtcac tgggaggatg 122520
aggctgtgag agcggcgcgg gctcgttacg aggcctcaac tgaacccgyg ccgctttacg 122580
tgccggagtt gggagatccg gctagacagt accgcgcgct gattaacctg atctactgtc 122640
cagacagaga ccctatagca tggctccaga accccaagct gaccggtgtc aactcggccc 122700
tgaaccagtt ctaccaaaag ctgttgccac cgggacgggc gggtaccgcc gttacgggga 122760
gcgtagcgtc tcccgttccg catgtaggcg aagccatggc cacgggggag gccctctggg 122820
ctctccccca cgcggccgcg gccgtggcta tgagccgtcg gtacgaccgg gcccaaaaac 122880
actttatcct acagagtctc cgcagagcct ttgccggcat ggcatacccc gaggcaacgg 122940
gctccagtcc ggcggcgcgg atctcccgcg gtcacccttc tccaacaacc ccggccacac 123000
agactcccga ccctcagccg tcggccgccg cgcgctctct ttctgtgtgt ccaccggatg 123060
atcgtttacg aactccgcgc aagcgcaagt cccagccagt cgagagcaga agcctcctcg 123120
acaagattag ggagacaccc gtcgcggacg cccgggttgc agacgatcat gtggtttcca 123180
aggccaagag gcgggtatcc gagcccgtga ccatcacctc gggccctgtg gtggatcccc 123240
ccgccgtaat aacgatgcca cttgacggac cggccccaaa cgggggattt cggcgtattc 123300
cccggggggc cctgcatacc ccggtcccgt cggaccaggc tcgcaaggcg tactgtaccc 123360
ccgaaaccat cgcccgtctg gtcgacgacc cattgtttcc cacggcctgg cgccctgcgc 123420
taagctttga tcccggcgcc ttggcggaaa tcgccgctcg gcgtccgggc ggaggagacc 123480
gacggtttgg tccacccagc ggagtggagg cgctgcgacg gaggtgcgcc tggatgcggc 123540
agatcccaga cccggaggat gtgaggcttc tgatcatcta cgatccgttg cccggagagg 123600
acatcaacgg ccccctcgag agcaccctcg cgacagatcc gggaccgtca tggagtccat 123660
cccgaggggg actgtctgtg gtcctggcag ccctgagtaa ccggttgtgc ctgccgagca 123720
ctcatgcctg ggccgggaac tggaccggcc cgccggacgt gtccgctttg aacgcccggg 123780
gcgttttatt actgtcgacc cgagacctgg cctttgccgg ggccgtcgag tatctaggct 123840
cgcggttggc ctctgcccgg cgccggttgc tggtgttgga cgcggtggcc ctcgagaggt 123900
ggcccgggga tggacccgct ttgtctcagt atcacgtgta cgtccgggcc ccggcgcgac 123960
cggacgccca ggccgtcgtc cgatggccag actcggcggt cacagaagga ctcgcccggg 124020
ccgtgtttgc atcgtcgcgc acctttgggc cagcgagttt tgctcgtatc gagactgcgt 124080
ttgccaacct gtacccgggc gaacaacccc tgtgtttgtg ccgcggtggg aacgtcgcat 124140
acaccgtgtg tacccgcgcg ggccccaaga cccgcgtccc cctgtcgccc cgtgaatacc 124200
ggcagtacgt gctgccgggt tttgacggtt gcaaggacct cgcgcgacag tctcggggtc 124260
tggggctcgg ggcagccgac tttgtggacg aggcggcaca tagccaccgc gcagcaaacc 124320
gatggggcct gggtgccgcg cttcgacccg tcttccttcc cgagggacgg agaccggggg 124380
ccgccgggcc ggaggccggc gacgtaccca cctgggcgag ggtgttttgc cgccacgccc 124440
tgctggaacc cgaccctgcc gcggaaccac tcgtgcttcc acccgtggcc ggtcggtcgg 124500
tggcgctgta tgcgtcggcg gacgaggctc ggaatgccct ccccccgatt cccagagtaa 124560
tgtggccgcc cggttttggg gccgcggaga cggtgttgga ggggagcgac ggaacacggt 124620
tcgcgttcgg acaccacggg ggctcggaac ggccggcaga aacccaggcg gggcgacagc 124680
ggcgcaccgc agacgacaga gaacacgctt tggagccgga cgattgggag gtggggtgtg 124740
aagacgcgtg ggacagcgag gaggggggcg gggacgacgg ggacgcaccg gggtcatcct 124800
ttggggtgag cgtcgtgtcg gtggccccgg gtgtgctgcg agaccgccgg gtgggctygc 124860
gcccggcggt caaggtggag ctgttgtcct cgtcctcgtc ctccgaggac gaggacgatg 124920
tgtggggagg gcgcgggggg aggagccccc cgcagagtcg ggggtgacgg agtcccctcc 124980
ttttctcgtg agcgccacyg gcgcgcggac tgtttgttgt ttgttaataa aagcggaacg 125040
gtttttatga aaaaagtgtc tgtctgtctg tgcgggcggg cgacgggcgg gctggtcgga 125100
ccccccccga aaataacccc ccccggtttc tgggcgcccg gcggaccccg ggggggg 125157
<210>3
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第560位核苷酸的突变的PCR引物
<400>3
tcgtttactg ctcggatggc gaccg 25
<210>4
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第560位核苷酸的突变的PCR引物
<400>4
gtgtttatgt atcagcatac agagc 25
<210>5
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第5745位核苷酸的突变的PCR引物
<400>5
attgtatgca tgcgattgct atcgc 25
<210>6
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第5745位核苷酸的突变的PCR引物
<400>6
ggtcttccac tttaaagggg tttgc 25
<210>7
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第26125位核苷酸的突变的PCR引物
<400>7
gaatcattag tatatatttt tctgc 25
<210>8
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第26125位核苷酸的突变的PCR引物
<400>8
tgttcagagg ggatgaatcg ttgcg 25
<210>9
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第94167位核苷酸的突变的PCR引物
<400>9
cgatcacgtc gctcacatcc aaccc 25
<210>10
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第94167位核苷酸的突变的PCR引物
<400>10
atggcagaag aaacacgtat tgccg 25
<210>11
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第105356、第105544、第124353和第124541位核苷酸的突变的PCR引物
<400>11
gaggacaaca gctccacctt gaccg 25
<210>12
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第105356、第105544、第124353和第124541位核苷酸的突变的PCR引物
<400>12
gagtaatgtg gccgcccggt tttgg 25
<210>13
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第105705、第106262、第123635和第124192位核苷酸的突变的PCR引物
<400>13
ccaaaaccgg gcggccacat tactc 25
<210>14
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第106705、第106262、第123635和第124192位核苷酸的突变的PCR引物
<400>14
attactgtcg acccgagacc tggcc 25
<210>15
<211>18
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第107136、第107252、第122645和第122761位核苷酸的突变的PCR引物
<400>15
gatcaaagct tagcgcag 18
<210>16
<211>18
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第107136、第107252、第122645和第122761位核苷酸的突变的PCR引物
<400>16
cctatagcat ggctccag 18
<210>17
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第108111和第121786位核苷酸的突变的PCR引物
<400>17
aagggcttcc gtcgggcatc atgag 25
<210>18
<211>25
<212>DNA
<213>人工序列
<220>
<223>人工序列的描述：用作检测水痘疫苗病毒的第108111和第121786位核苷酸的突变的PCR引物
<400>18
tcgggtaaaa agccgggcga tgagc 25
Claims (9)
1.一种减毒水痘活疫苗质量控制的方法，包括把水痘疫苗病毒样品的基因组DNA进行序列分析和证实所说的水痘疫苗病毒样品的基因组DNA中下面的5个核苷酸是保守的而没有发生突变：
第5,745位的G、第105,356位的C、第105,544位的G、第106,262位的C和第107,252位的C，
其中的核苷酸编号与SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的。
2.依据权利要求1的方法，其中所述5个核苷酸的组合的保守性由应用下列引物的RFLP分析所证实：
SEQ ID NO：5和6的一对引物，证实第5,745位的G；
SEQ ID NO：11和12的一对引物，证实第105,356位的C和第105,544位的G；
SEQ ID NO：13和14的一对引物，证实第106,262位的C；和
SEQ ID NO：15和16的一对引物，证实第107,252位的C。
3.依据权利要求1或2的方法，进一步包括证实所述水痘疫苗病毒样品的基因组DNA中下列4个核苷酸是保守的而没有发生突变：
第122,645位的G、第123,635位的G、第124,353位的C和第124,541位的G，
其中的核苷酸编号与SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的。
4.依据权利要求3的方法，其中，所述4个核苷酸的保守性通过应用下列引物进行的RFLP分析所证实：
SEQ ID NO：11和12的一对引物，证实第124,353位的C和第124,541位的G；
SEQ ID NO：13和14的一对引物，证实第123,635位的G；和
SEQ ID NO：15和16的一对引物，证实第122,645位的G。
5.依据权利要求1到4中任何一项的方法，进一步包括证实所述水痘疫苗病毒样品的基因组DNA中下列49个核苷酸是保守的而没有发生突变：
第560位的C，第703位的Y，第763位的Y，第2,515位的Y，第10,900位的Y，第12,779位的Y，第19,431位的Y，第26,125位的G，第31,732位的Y，第38,036位的Y，第39,227位的K，第58,595位的R，第59,287位的R，第64,067位的R，第71,252位的Y，第82,225位的R，第84,091位的R，第87,280位的R，第87,306位的Y，第89,734位的R，第90,535位的R，第94,167位的C，第97,748位的R，第97,796位的Y，第101,089位的R，第105,169位的R，第105,310位的R，第105,705位的C，第106,710位的R，第107,136位的C，第107,599位的R，第107,797位的R，第108,111位的C，第108,838位的R，第109,137位的R，第109,200位的R，第111,650位的R，第118,247位的Y，第120,697位的Y，第120,760位的Y，第121,059位的Y，第121,786位的G，第122,100位的Y，第122,298位的Y，第122,761位的G，第123,187位的Y，第124,192位的G，第124,587位的Y和第124,728位的Y，
其中：
核苷酸编号与SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的核苷酸序列的核苷酸编号***是一致的，
R代表A或G，
Y代表C或T，和
K代表G或T。
6.依据权利要求5的方法，其中，在所述49个核苷酸中第560位的C、第26,125位的G、第94,167位的C、第105,705位的C、第107,136位的C、第108,111位的C、第121,786位的G、第122,761位的G和124,192位的G的保守性被应用下列引物进行的RFLP分析所证实：
SEQ ID NO：3和4的一对引物，证实第560位的C；
SEQ ID NO：7和8的一对引物，证实第26,125位的G；
SEQ ID NO：9和10的一对引物，证实第94,167位的C；
SEQ ID NO：13和14的一对引物，证实第105,705位的C和第124,192位的G；
SEQ ID NO：15和16的一对引物，证实第107,136位的C和第122,761位的G；和
SEQ ID NO：17和18的一对引物，证实第108,111位的C和第121,786位的G。
7.依据权利要求1到6中任何一项的方法，进一步包括证实在所述水痘疫苗病毒样品的基因组DNA的两个复制起始点中的缺失突变，
其中所说的两个复制起始点是对应于SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的有义链的第110,087位到第110,350位核苷酸的区域和对应于所述Dumas株的反义链的基因组DNA的第119,547位到第119,810位核苷酸的区域，和
其中所说的缺失突变发生在每一个具有从5’端到3’端方向排列的ATATATATA的核苷酸序列的片断上，所说的片断是对应于所说的Dumas株的基因组DNA的有义链的第110,219位到第110,227位核苷酸的一个片断和对应于所说的Dumas株的基因组DNA的反义链的第119,670位到第119,678位核苷酸的一个片断。
8.依据权利要求1到7中任何一项的方法，进一步包括证实所说的水痘疫苗病毒样品的基因组DNA的一个完整R1区的重复序列是一个具有从5’端到3’端方向排列的abbabba’bbb’abababx的核苷酸序列，
其中，
a代表GGACGCGATCGACGACGA的一个核苷酸序列；
a’代表GGACGCGATTGACGACGA的一个核苷酸序列；
b代表GGGAGAGGCGGAGGA的一个核苷酸序列；
b’代表GGACGCGGCGGAGGA的一个核苷酸序列；和
x代表GGA的一个核苷酸序列，
其中所说的完整R1区域是对应于SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的第13,937位到第14,242位核苷酸的区域。
9.依据权利要求1的方法，该方法进一步包括证实所述水痘疫苗病毒样品的基因组DNA的两个完整R4区中的每一个的重复序列是具有从5’端到3’端方向排列的aaaaaaaaaaaax的核苷酸序列，
其中，
a代表CCCCGCCGATGGGGAGGGGGCGCGGTA的一个核苷酸序列；和
x代表CCCCGCCGATG的一个核苷酸序列，
其中所说的两个完整R4区域是对应于SEQ ID NO：1的水痘病毒Dumas株的基因组DNA的有义链的第109,762位到第109,907位核苷酸的一个区域和对应于所述Dumas株的基因组DNA的反义链的第119,990位到第120,135位核苷酸的一个区域。
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| US (1) | US6653069B2 (zh) |
| EP (1) | EP1166797B1 (zh) |
| JP (1) | JP3946045B2 (zh) |
| KR (1) | KR100441459B1 (zh) |
| CN (1) | CN1188167C (zh) |
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| CN101967466A (zh) * | 2009-07-28 | 2011-02-09 | 新泽西医学院 | Orf7缺陷型水痘病毒株、含有该毒株的疫苗及其应用 |
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| KR100441459B1 (ko) | 2004-07-23 |
| EP1166797B1 (en) | 2006-12-06 |
| EP1166797A1 (en) | 2002-01-02 |
| CN1358101A (zh) | 2002-07-10 |
| DE60124984T2 (de) | 2007-09-20 |
| EP1166797A4 (en) | 2003-04-09 |
| CA2359659C (en) | 2006-10-17 |
| CA2359659A1 (en) | 2001-08-09 |
| US20030082210A1 (en) | 2003-05-01 |
| WO2001056600A1 (fr) | 2001-08-09 |
| JP3946045B2 (ja) | 2007-07-18 |
| US6653069B2 (en) | 2003-11-25 |
| KR20010103783A (ko) | 2001-11-23 |
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