CN1183906C - Preparation process for surfacce anesthesia cream - Google Patents
Preparation process for surfacce anesthesia cream Download PDFInfo
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- CN1183906C CN1183906C CN 01108418 CN01108418A CN1183906C CN 1183906 C CN1183906 C CN 1183906C CN 01108418 CN01108418 CN 01108418 CN 01108418 A CN01108418 A CN 01108418A CN 1183906 C CN1183906 C CN 1183906C
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- hydrochloride
- topical anesthesia
- anesthesia cream
- cream
- azone
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Abstract
The present invention relates to a preparation process for surface anesthesia cream, which is characterized in that the surface anesthesia cream is prepared by mixing 0.5 to 4% of lidocaine hydrochloride, 0.5 to 4% of tetracaine hydrochloride, 1 to 5% of thickening agents, 0 to 15% of wetting agents, 0 to 1.5% of azone, 0 to 0.4% of kathon and distilled water as the rest. The present invention provides a novel preparation process for surface anesthesia cream, which has the advantages of strong osmosis for mucous membranes and skin, rapid effect taking, no stimulation or allergic reaction and low cost, and certain effects can be maintained.
Description
The invention belongs to the preparation field of medicine, specifically is a kind of compound method of topical anesthesia cream.
Existing topical anesthesia cream is used for clinical skin surface anesthesia history of existing more than ten years as " En Na " emulsifiable paste from external import, but owing to onset limits its application slowly, about 1～2 hour of onset time of skin.And cost an arm and a leg, 5% " En Na " emulsifiable paste, 5 grams need 47 yuan of RMB, are very unpractical for present our domestic consumption level.
The objective of the invention is for the public provides a kind of osmosis to mucosa, skin strong, rapid-action, non-stimulated or anaphylaxis, and can keep certain timeliness the compound method of the novel surface anesthesia cream that cost is low in order to overcome the deficiencies in the prior art.
The objective of the invention is to realize by following technical proposals.
The compound method of topical anesthesia cream of the present invention is to be that distilled water is hybridly prepared into topical anesthesia cream with 0.5～4% lidocaine hydrochloride, 0.5～4% tetracaine hydrochloride, 1～5% thickening agent, 0～15% wetting agent, 0～1.5% azone, 0～0.4% Kazon, surplus.
In the such scheme, thickening agent is carboxymethyl cellulose, polyethylene glycol 6000.
In the such scheme, wetting agent is propylene glycol, glycerol.
In the such scheme, it is standby to get lidocaine hydrochloride 0.5～4%, tetracaine hydrochloride 0.5～4%, polyethylene glycol 6000 1～5%, propylene glycol 0～15%, azone 0～1.5%, Kazon 0～0.4%, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride are dissolved in 50～80% the distilled water, add polyethylene glycol 6000, azone again, be heated to 60～80 ℃, stirring makes the polyethylene glycol 6000 dissolving, adding distil water to 100% while hot, be cooled to about 40 ℃ and add Kazon, stir evenly and promptly get topical anesthesia cream.
In the such scheme, it is standby to get lidocaine hydrochloride 0.5～4%, tetracaine hydrochloride 0.5～4%, carboxymethyl cellulose 1～5%, glycerol 0～15%, azone 0～1.5%, Kazon 0～0.4%, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride, glycerol, azone are dissolved in 50～80% the distilled water, add carboxymethyl cellulose, stirring makes its dissolving, add Kazon again, adding distil water to 100% stirs evenly and promptly gets topical anesthesia cream.
Outside demineralizing acid lignocaine of the present invention, two main components of tetracaine hydrochloride, remaining additive all can adopt medical similar products, as other thickening agent, wetting agent, penetrating agent etc.
Topical anesthesia cream of the present invention, strong, rapid-action, the non-stimulated or anaphylaxis to the osmosis of mucosa, skin, and can keep certain timeliness.Pipe is put in clinical topical anesthesia when can be used for tracheal intubation, minor operation that the skin table is shallow, (as peritomize, condyloma acuminatum and other laser therapy), venipuncture, waist is worn, intramuscular injection etc., also can be used for bark fetching, burn, the pain relieving of scald and the eyebrow tattooing of cosmetic surgery, profiling eyelid line, the hair or the like of plucking eyebrows.
Its advantage is: smear " topical anesthesia cream " on the endotracheal tube surface during (1) tracheal intubation and can reduce the stimulation of endotracheal tube to tracheal wall, avoid the complication of coughing, holding one's breath etc. and cause because of choking.Can keep shallow general anesthesia, circulation is kept steadily easily, reduce respiratory disturbance, particularly cranium is pressed high patient, having avoided chokes in the art coughs, holds one's breath etc. and make cranium press the danger of increasing suddenly, and can reduce the consumption of anesthetics, can be used for the topical anesthesia of various endotracheal tube intubate.(2) for the shallow minor operation of some tables, as peritomize, condyloma acuminatum and other laser therapy, eyebrow tattooing, profiling eyelid line etc. can be avoided the hardship of having an injection.(3) put pipe for venipuncture, waist is worn, intramuscular injection etc. also can palliate the agonizing sufferings.(4) reduce expenses, 5 grams " topical anesthesia cream " approximately only need about 15 yuan, and this just reduces patient's medication expense greatly.
Be embodiments of the invention below.The present invention is not limited only to described embodiment.
Embodiment one
Get lidocaine hydrochloride 2.5g, tetracaine hydrochloride 1.5g, polyethylene glycol 6000 5.0g, propylene glycol 15g, azone 0.8g, Kazon 0.2g are standby, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride are dissolved in the 50ml distilled water, add polyethylene glycol 6000, azone again, be heated to 80 ℃, stirring makes the polyethylene glycol 6000 dissolving, adding distil water is to 100g while hot, is cooled to about 40 ℃ to add Kazon, stirs evenly and promptly gets product.
Embodiment two
Get lidocaine hydrochloride 2.5g, tetracaine hydrochloride 1.5g, carboxymethyl cellulose 1.7g, glycerol 10g, azone 1.0g, Kazon 0.2g are standby, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride, glycerol, azone are dissolved in the 80ml distilled water, add carboxymethyl cellulose, stirring makes its dissolving, add Kazon again, adding distil water stirs evenly and promptly gets product to 100g.
Embodiment three
Get lidocaine hydrochloride 0.5g, tetracaine hydrochloride 4g, carboxymethyl cellulose 1g, azone 0.5g, Kazon 0.4g is standby, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride, azone are dissolved in the 80ml distilled water, add carboxymethyl cellulose, stirring makes its dissolving, add Kazon again, adding distil water stirs evenly and promptly gets product to 100g.
Embodiment four
Get lidocaine hydrochloride 4g, tetracaine hydrochloride 0.5g, polyethylene glycol 6000 4g, Kazon 0.2g are standby, then with above-mentioned lidocaine hydrochloride, tetracaine hydrochloride, be dissolved in the 80ml distilled water, add polyethylene glycol 6000, be heated to 60 ℃, stirring makes the polyethylene glycol 6000 dissolving, adding distil water is to 100g while hot, is cooled to about 40 ℃ to add Kazon, stirs evenly and promptly gets product.
Embodiment five
Get lidocaine hydrochloride 2.5g, tetracaine hydrochloride 1.5g, carboxymethyl cellulose 1g, glycerol 15g, azone 1.5g, Kazon 0.2g are standby, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride, glycerol, azone are dissolved in the 50ml distilled water, add carboxymethyl cellulose, stirring makes its dissolving, add Kazon again, adding distil water stirs evenly and promptly gets product to 100g.
Embodiment six
Get lidocaine hydrochloride 1.5g, tetracaine hydrochloride 1.5g, carboxymethyl cellulose 3g, azone 1.5g, Kazon 0.4g is standby, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride, azone are dissolved in the 80ml distilled water, add carboxymethyl cellulose, stirring makes its dissolving, add Kazon again, adding distil water stirs evenly and promptly gets product to 100g.
Embodiment seven
Get lidocaine hydrochloride 2.5g, tetracaine hydrochloride 1.5g, carboxymethyl cellulose 1.7g is standby, then above-mentioned lidocaine hydrochloride, tetracaine hydrochloride are dissolved in the 70ml distilled water, add carboxymethyl cellulose, stir and make its dissolving, adding distil water stirs evenly and promptly gets product to 100g.
Claims (4)
1, the compound method of topical anesthesia cream is characterized in that being is that distilled water be hybridly prepared into topical anesthesia cream as thickening agent, 0～15% propylene glycol or glycerol as wetting agent, 0.5～1.5% azone, 0.2～0.4% Kazon, surplus with 0.5～4% lidocaine hydrochloride, 0.5～4% tetracaine hydrochloride, 1～5% carboxymethyl cellulose or polyethylene glycol 6000.
2, the compound method of topical anesthesia cream according to claim 1, it is characterized in that described lidocaine hydrochloride, tetracaine hydrochloride are dissolved in 50～80% the distilled water, add polyethylene glycol 6000, azone again, be heated to 60～80 ℃, stirring makes the polyethylene glycol 6000 dissolving, adding distil water to 100% while hot is cooled to about 40 ℃ and adds Kazon, stirs evenly and promptly gets topical anesthesia cream.
3, the compound method of topical anesthesia cream according to claim 1, it is characterized in that described lidocaine hydrochloride, tetracaine hydrochloride, glycerol, azone are dissolved in 50～80% the distilled water, add carboxymethyl cellulose, stirring makes its dissolving, add Kazon again, adding distil water to 100% stirs evenly and promptly gets topical anesthesia cream.
4, according to the prepared topical anesthesia cream of the compound method of the described topical anesthesia cream of one of claim 1～3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01108418 CN1183906C (en) | 2001-05-11 | 2001-05-11 | Preparation process for surfacce anesthesia cream |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01108418 CN1183906C (en) | 2001-05-11 | 2001-05-11 | Preparation process for surfacce anesthesia cream |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1385153A CN1385153A (en) | 2002-12-18 |
| CN1183906C true CN1183906C (en) | 2005-01-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01108418 Expired - Fee Related CN1183906C (en) | 2001-05-11 | 2001-05-11 | Preparation process for surfacce anesthesia cream |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1183906C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100443079C (en) * | 2003-12-09 | 2008-12-17 | 上海第二医科大学 | Method for fabricating preparation of del for anesthesia and analgesia on surface of skin |
| CN100443078C (en) * | 2003-12-09 | 2008-12-17 | 上海第二医科大学 | Gel for local anesthesia and analgesia on surface of skin, and usage |
| CN104825386A (en) * | 2015-05-25 | 2015-08-12 | 湖北汇瑞药业股份有限公司 | Epidermal anesthesia gel and preparation method thereof |
| CN106138530A (en) * | 2016-07-30 | 2016-11-23 | 李秀军 | A kind of surgery skin analgesia cream |
| CN107252490B (en) * | 2017-07-12 | 2019-12-03 | 云平 | A kind of local anaesthesia drug and preparation method thereof |
| CN108272746A (en) * | 2018-03-06 | 2018-07-13 | 佳木斯大学附属第二医院(佳木斯大学附属口腔医院) | A kind of doctor trained in Western medicine surgery skin analgesia cream and preparation method thereof |
-
2001
- 2001-05-11 CN CN 01108418 patent/CN1183906C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1385153A (en) | 2002-12-18 |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: HUAXI HOSPITAL ATTACHED TO SICHUAN UNIV. Free format text: FORMER OWNER: ZHANG GUOZHI Effective date: 20070216 |
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| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20070216 Address after: 37 anesthesia department, West China Hospital,, Chengdu 610041, Sichuan, China Patentee after: West China Hospital of Sichuan University Address before: 610041, No. 2, unit 1, 15 East Street, Wuhou District, Sichuan, Chengdu Patentee before: Zhang Guozhi |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050112 Termination date: 20150511 |
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| EXPY | Termination of patent right or utility model |