CN118303861A - Optical endoscopic lighting device, imaging device and electronic endoscope - Google Patents

Abstract

The invention discloses an optical endoscopic lighting device, an imaging device and an electronic endoscope, and relates to the technical field of endoscopes, wherein the optical endoscopic lighting device comprises a single transverse mode narrow bandwidth laser, a low NA optical fiber, a microsphere lens and an endoscope, wherein the single transverse mode narrow bandwidth laser is used for generating high-coherence laser, a light incident end of the low NA optical fiber is directly coupled with the single transverse mode narrow bandwidth laser, and the microsphere lens is fixed at an emergent end of the low NA optical fiber; the illumination channel of the endoscope is provided with a light cone and an illumination fiber bundle, the light cone of the endoscope is coupled with the microsphere lens, and because the single transverse mode narrow bandwidth laser is directly coupled into the illumination fiber bundle of the endoscope through the low NA fiber and the microsphere lens, compared with the conventional endoscopic type LSFI, the laser is coupled into the fiber bundle for one time, namely, the loss of the energy and the coherence of the laser for one time is reduced, and the laser illumination with high coherence, high coupling efficiency, high uniformity and large illumination angle under the endoscope can be realized.

Description

Optical endoscopic lighting device, imaging device and electronic endoscope

Technical Field

The invention relates to the technical field of endoscopes, in particular to an optical endoscopic lighting device, an imaging device and an electronic endoscope.

Background

In surgery, doctors place great importance on the state of tissue blood flow microcirculation, for example: in organ resection, a doctor needs to visualize a blood vessel in real time; in colorectal cancer resection, a doctor needs to judge the anastomosis condition after tumor resection according to whether blood flow is supplied; acute mesenteric ischemia patients need to evaluate the mesenteric blood flow microcirculation state in real time, and the blood flow microcirculation state has important reference function on the operation.

Laser speckle blood flow endoscopic imaging is a combination of laser speckle blood flow imaging technology (LASER SPECK LE F low imaging, LSFI) and endoscopic imaging, and can realize blood perfusion during operation. LSFI achieve rapid, full-field detection of blood flow by analyzing the degree of blurring caused by dynamic speckle patterns. The laser is used as an illumination light source, the two-dimensional wide-field imaging can be carried out on the blood flow of biological tissues without scanning, the time and the spatial resolution can respectively reach the order of several milliseconds and several micrometers, and the method has the advantages of real-time rapidness, high resolution, no need of contrast agent marking and non-contact detection. LSFI in combination with an endoscope can be used as an effective means for visualization of blood vessels of internal organs and diagnosis of diseases in operation, and can provide information of blood supply states or disease assessment in vivo for doctors in real time.

The existing endoscopic laser speckle blood flow imaging adopts LSFI and rigid endoscope, in the existing endoscopic laser speckle blood flow imaging technology, laser is coupled into an endoscope illumination optical fiber through a large NA multimode optical fiber bundle, the laser illumination view field of the laser illumination mode is smaller than the imaging view field, the illumination intensity is relatively uneven, the laser illumination coherence is low and the laser coupling efficiency is low, so that LSFI view field is small, blood flow measurement in the view field is inaccurate, poor contrast-blood flow linear fitting is realized in the working distance, LSFI effective working distance is short, and larger specular reflection interference exists.

On the other hand, electronic endoscopes are rapidly developing due to the development of CMOS technology. The external diameter of the electronic endoscope is thinner, which can greatly reduce the pain of patients. And the performance of the electronic endoscope is greatly improved. The endoscopic laser speckle blood flow imaging technology based on the electronic endoscope can be applied to more department scenes. However, no endoscopic laser speckle blood flow imaging technology based on an electronic endoscope has been proposed.

Disclosure of Invention

The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the invention provides an optical endoscopic lighting device which can realize laser lighting with high coherence, high coupling efficiency, high uniformity and large lighting angle under an endoscope.

The invention also provides an imaging device.

The invention also provides an endoscopic lighting device.

The invention also provides an electronic endoscope.

The invention also provides another electronic endoscope.

In a first aspect, an embodiment of the present invention provides an optical endoscopic lighting device, including a single transverse mode narrow bandwidth laser for generating high coherence laser light, a low NA optical fiber, a microsphere lens, and an endoscope, the low NA optical fiber light incident end and the single transverse mode narrow bandwidth laser being directly coupled, the microsphere lens being fixed to the low NA optical fiber exit end to increase an angle of the high coherence laser light exiting the low NA optical fiber; the endoscope is an endoscope with an illumination channel provided with a light cone and an illumination fiber bundle, and the light cone of the endoscope is coupled with the microsphere lens.

The optical endoscopic lighting device provided by the embodiment of the invention has at least the following beneficial effects: the microsphere lens is used for increasing the angle of emergent laser in the low NA optical fiber, so that after single transverse mode narrow bandwidth laser is directly coupled into the laparoscopic optical fiber bundle through the low NA optical fiber and the microsphere lens, compared with the conventional endoscopic type LSFI, the microsphere lens is less in one-time laser coupling into the optical fiber bundle, namely less in energy and coherence loss of one-time laser, and therefore after the laser emitted by the low NA optical fiber and the microsphere lens is coupled into the endoscope illumination optical fiber, high coherence, high coupling efficiency, high uniformity and large illumination angle laser illumination under the endoscope can be realized.

According to further embodiments of the present invention, the optical endoscopic illumination device further comprises an incoherent light source, an incoherent light guide beam and a mount, the incoherent light source conducting incoherent light to the mount through the incoherent light guide beam; the device comprises a mounting seat, a first dichroic mirror, a second dichroic mirror, a first mounting seat light inlet, a second mounting seat light inlet and a microsphere lens, wherein the first dichroic mirror is fixed inside the mounting seat and is used for combining high-coherence laser and incoherent light beams, the first mounting seat light inlet, the second mounting seat light inlet and the microsphere lens are arranged outside the mounting seat, the second mounting seat light inlet is used for fixing the incoherent light beams, and the light outlet of the mounting seat is directly coupled with an endoscope light cone.

According to other embodiments of the present invention, the incoherent light guide beam is a glass fiber optic bundle, a quartz fiber optic bundle, a plastic fiber optic bundle, or a liquid optical waveguide.

According to other embodiments of the present invention, the incoherent light source is an LED, mercury lamp or xenon lamp.

According to other embodiments of the present invention, the single transverse mode narrow bandwidth laser source has a wavelength of 200-2000nm, a transverse modulus of 1, and a power of 10mW-900mW.

In a second aspect, one embodiment of the present invention provides an imaging device comprising an endoscopic illumination device and an adapter mounted to an eyepiece viewing end of an endoscope, a dichroic mirror two, a camera one and a camera two, the adapter being located between the eyepiece and the dichroic mirror two, the dichroic mirror two incident end being coupled to the adapter, the dichroic mirror two exit end being coupled to the camera one and the camera two, respectively; the dichroic mirror II is used for dividing light from a sample into visible light and near infrared light, and the visible light and the near infrared light are respectively used for bright field imaging and laser speckle blood flow imaging; the first camera is used for receiving visible light signals scattered by the incoherent light on the sample, and the second camera is used for receiving laser speckle signals scattered by the high-coherence laser on the sample.

The imaging device provided by the embodiment of the invention has at least the following beneficial effects: because the imaging device comprises the endoscopic illumination device, the imaging device can realize endoscopic bright field imaging and laser speckle blood flow imaging.

In a third aspect, an embodiment of the present invention provides an endoscopic lighting device, including the single transverse mode narrow bandwidth laser, a low NA optical fiber, a microsphere lens, and an endoscope, where the single transverse mode narrow bandwidth laser is used to generate high coherence laser, the light incident end of the low NA optical fiber is directly coupled with the single transverse mode narrow bandwidth laser, the microsphere lens is fixed at the light emergent end of the low NA optical fiber to increase the angle of high coherence laser emitted from the low NA optical fiber, and the low NA optical fiber and the microsphere lens are both disposed around the objective lens of the endoscope.

The endoscopic lighting device provided by the embodiment of the invention has at least the following beneficial effects: the single transverse mode narrow band laser, the low NA optical fiber and the microsphere lens can provide high coherence, large illumination angle and high uniformity for the electronic endoscope.

According to other embodiments of the invention, the low NA fiber and the microsphere lenses are one or more groups and are fixed around the endoscope objective lens.

In a fourth aspect, one embodiment of the present invention provides an electronic endoscope comprising a single transverse mode narrow band laser, a low NA fiber, a microsphere lens, and a working channel; the single transverse mode narrow bandwidth laser is used for generating a high-coherence laser light source, the light incidence end of the low NA optical fiber is coupled with the single transverse mode narrow bandwidth laser, and the microsphere lens is fixed at the emergent end of the low NA optical fiber so as to increase the angle of the high-coherence laser emergent from the low NA optical fiber; the low NA optical fiber and the microsphere lens are both arranged in a working channel of the electronic endoscope, and the microsphere lens is fixed around the objective lens of the electronic endoscope.

The electronic endoscope provided by the embodiment of the invention has at least the following beneficial effects: in the electronic endoscope, the single transverse mode narrow-band laser, the low NA optical fiber and the microsphere lens can provide high coherence, large illumination angle and high uniformity for the electronic endoscope, and compared with a hard endoscope, the electronic endoscope has incomparable advantages in size, and better imaging quality compared with a fiber endoscope, so that the electronic endoscope based on the endoscopic LSFI of the electronic endoscope has a large application scene.

In a fifth aspect, an embodiment of the present invention provides an electronic endoscope, including a single transverse mode narrow-band laser and a microsphere lens disposed at an imaging end of the electronic endoscope, where the microsphere lens is coupled to an light emitting side of the single transverse mode narrow-band laser, and the microsphere lens is configured to expand a high coherence laser generated by the single transverse mode narrow-band laser; the single transverse mode narrow bandwidth laser and the microsphere lens are coupled to form a laser illumination module, and one or more groups of laser illumination modules are arranged.

The electronic endoscope provided by the embodiment of the invention has at least the following beneficial effects: the electronic endoscope is directly provided with the single transverse mode narrow bandwidth laser and the microsphere lens at the imaging end, so that laser emitted by the single transverse mode narrow bandwidth laser can be directly shaped and expanded by the microsphere lens without optical fibers, and the illumination view field of the electronic endoscope is larger than the imaging view field of the electronic endoscope in the fourth invention.

According to other embodiments of the present invention, the electronic endoscope further comprises an LED light source, wherein a microsphere lens is coupled to the light emitting side of the LED light source, and the microsphere lens is used for expanding incoherent light generated by an LED; the LED light source and the microsphere lens are coupled to form an LED lighting module, and one or more groups of LED lighting modules are arranged; the laser illumination modules and the LED illumination modules are uniformly arranged along the circumferential direction of the imaging end of the electronic endoscope.

According to other embodiments of the present invention, an electronic endoscope has an imaging chip at an imaging end, where a pixel frame of the imaging chip is a 4×4 pixel combined rgb+ I R chip, and the imaging chip can perform RGB and near infrared imaging.

Of course, it is not necessary for any one product to practice the invention to achieve all of the advantages set forth above at the same time.

Drawings

Fig. 1 is a schematic structural view of an endoscopic illumination device according to a first invention.

Fig. 2 is a view showing the position of an endoscope illumination fiber in the first invention.

Fig. 3 is a schematic view of the structure of the imaging end of the endoscope in the first invention.

Fig. 4 is a schematic diagram of the first invention in which the incoherent light source of fig. 1 is incorporated.

Fig. 5 is a schematic structural view of the mounting base in the first invention.

Fig. 6 is a schematic structural diagram of an image forming apparatus according to the second invention.

Fig. 7 is a schematic end view of a single transverse mode narrow bandwidth laser, low NA fiber and microsphere lens integrated into a working channel in a fourth invention.

Fig. 8 is a diagram showing distribution diagrams of a laser lighting module and an LED lighting module in a fifth invention.

Fig. 9 is a schematic structural diagram of an imaging chip in the fifth invention.

In the figure, a single transverse mode narrow bandwidth laser; 2. a low NA optical fiber; 3. a microsphere lens; 4. an endoscope; 41. an imaging end; 42. an eyepiece; 5. a light cone; 6. an illumination fiber; 7. a non-coherent light source; 8. a mounting base; 81. a first light inlet; 82. a second light inlet; 83. a light outlet; 84. a dichroic mirror I; 9. an adapter; 10. a first camera; 11. a second camera; 12. a dichroic mirror II; 13. a working channel; 14. incoherent light guide beams; 15. an imaging chip; 16. a laser illumination module; 17. an LED lighting module; 18. an electronic endoscope; 19. and (3) an imaging channel.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

In the description of the present invention, it should be understood that the terms "open," "upper," "lower," "thickness," "top," "middle," "length," "inner," "peripheral," and the like indicate orientation or positional relationships, merely for convenience in describing the present invention and to simplify the description, and do not indicate or imply that the components or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention.

Referring to fig. 1 and 2, in one aspect, the present invention provides an optical endoscopic illumination device, which includes a single transverse mode narrow bandwidth laser 1, a low NA optical fiber 2, a microsphere lens 3 and an endoscope 4, wherein the single transverse mode narrow bandwidth laser 1 is used for generating high coherence laser, a light incident end of the low NA optical fiber 2 is directly coupled with the single transverse mode narrow bandwidth laser 1, and the microsphere lens 3 is fixed at an emitting end of the low NA optical fiber 2 to increase an angle of emitting the high coherence laser from the low NA optical fiber 2; the endoscope 4 is an endoscope with an illumination channel provided with a light cone 5 and an illumination fiber bundle, the light cone 5 of the endoscope 4 is coupled with the microsphere lens 3, and the illumination fiber bundle is illuminated by the endoscope 4 to generate laser illumination required by endoscopic laser speckle blood flow imaging; after the high-coherence laser emitted from the microsphere lens 3 is coupled into the light cone 5 and the illumination optical fiber 6 of the endoscope 4, laser illumination with high coherence, high coupling efficiency, high uniformity and large illumination angle under the endoscope can be realized.

In addition, as shown in fig. 2, the illumination fiber 6 extends to the imaging end 41 so as to transmit high coherence laser light to the imaging end 41 for illumination; fig. 3 is a schematic end view of the illumination fiber 6 at the imaging end 41.

In the endoscope 4, the optical fiber bundle has a honeycomb structure, only the core layer of each optical fiber of the optical fiber bundle can transmit laser, and the conventional endoscopic LSFI laser illumination needs to be coupled into the optical fiber bundle through three laser coupling processes (laser-multimode optical fiber bundle-endoscope light cone 5-endoscope illumination optical fiber 6), so that the coupling efficiency is low. For endoscopes, the longer the working distance, the smaller the effective NA, and the less signal laser light from the sample to the camera. The intra-operative working distance (> 30 mm) is long and only a very small fraction of the laser light scattered from the sample reaches the camera. Thus, for endoscopic laser speckle blood imaging, a sufficiently high power laser is required to irradiate the sample. Although the detected laser speckle signal may be increased by selecting a high power laser, the high power laser corresponds to a multi-transverse-longitudinal-mode laser source that produces low coherence laser light that results in inaccurate blood flow measurements. In the invention, because the single transverse mode narrow bandwidth laser is directly coupled into the laparoscopic illumination optical fiber bundle through the low NA optical fiber 2 and the microsphere lens 3, compared with the conventional endoscopic type LSFI, the single transverse mode narrow bandwidth laser is less in one-time laser coupling into the optical fiber bundle, namely the loss of one-time laser is less.

High coherence: due to the imaging principle of LSFI, high coherence laser illumination can detect more accurate and weak blood flow changes. The speckle contrast C after laser passing through the fiber is:

Wherein Deltalambda is the spectral width of the laser, NA is the numerical aperture of the optical fiber, L is the length of the optical fiber, lambda is the wavelength of the laser, n1 is the refractive index of the fiber core of the optical fiber, and M is the transverse modulus of the laser.

The conventional endoscopic type LSFI has the advantages that as three times of laser coupling are carried out to the large NA optical fiber bundle, the laser coherence is greatly reduced, and the accuracy of blood flow detection is further reduced, and the scheme that single transverse mode narrow bandwidth laser is directly coupled to the large NA optical fiber bundle through the low NA optical fiber and the microsphere lens instead of the first time of laser coupling can reduce the loss of the laser coherence by the whole optical fiber, so that the accuracy of LSFI detection of blood flow is improved.

Large illumination angle: compared with the conventional endoscopic LSFI laser illumination mode, the laser illumination mode provided by the invention has a larger illumination angle. The laser is directly coupled into the laparoscope illumination optical fiber 6 through a large NA multimode optical fiber bundle, and the emergent laser illumination angle is far smaller than the imaging field of view. The laser light causes multimode optical fiber interference (MMFI) in the optical fiber, and among the excited light of the plurality of modes, the light of the low-order mode corresponds to a small divergence angle, and the light of the high-order mode corresponds to a large divergence angle. While higher order modes excite higher order modes than lower order modes. In conventional endoscopic LSFI laser illumination, the first MMFI is excited by the fundamental mode of the laser, the second MMFI is excited by the first excited multiple modes of light, and the third MMFI is excited by the second excited multiple modes of light. Nevertheless, MMFI of conventional endoscope LSFI is not sufficiently developed, and the mode of the finally generated third MMFI excited light is still not high enough, i.e. the divergence angle of the laser light finally exiting from the endoscope illumination fiber 6 is still much smaller than the imaging field of view of the endoscope. Whereas in the present invention, the first MMFI is excited in low NA by the fundamental mode of the laser, however, after the light divergence angle through the microsphere lens 3 increases, the second MMFI is excited by higher order mode light, and the third MMFI is excited by higher order mode light. Compared with the conventional endoscopic type LSFI, the endoscopic type LSFI laser illumination method provided by the invention has a larger laser illumination angle.

High uniformity: according to the description of the large illumination angle in the upper section, the divergence angle of the laser light finally emitted from the endoscope illumination fiber 6 is larger, so that the overall combined illumination is more uniform, and the combined illumination is different from the conventional endoscope type LSFI in that the illumination intensity with strong middle and weak periphery is generated.

Preferably, the microsphere lens 3 is directly attached to the light outlet of the low NA optical fiber 2, the diameter is 0.1-9 mm, the focal length is 0.1-9 mm, and the laser angle emitted by the low NA optical fiber 2 can be enlarged to 90 degrees.

As shown in fig. 4 and 5, the above-mentioned endoscopic LSFI single-mode imaging is also very important, so that the incoherent light source 7 and the incoherent light guide beam 14 can be added without changing, and the mounting base 8 is additionally arranged in the light-entering area (i.e. the position of the light cone 5) of the endoscope, and the incoherent light source 7 transmits incoherent light to the mounting base 8 through the incoherent light guide beam 14.

In order to couple both incoherent light and high-coherence laser light into the light cone 5, a dichroic mirror 84 is provided in the mount 8, the dichroic mirror 84 being used for combining the high-coherence laser light and the incoherent light.

The above-mentioned mounting seat 8 specifically comprises a first light inlet 81, a second light inlet 82 and a light outlet 83, the first light inlet of the mounting seat 8 is connected with the microsphere lens 3, the second light inlet 82 of the mounting seat 8 is used for fixing the incoherent light guide beam 14, and the light outlet 83 of the mounting seat 8 is directly coupled with the light cone 5 of the endoscope 4; in conclusion, the subsequent laser speckle blood flow imaging and bright field imaging can be realized.

Preferably, the dichroic mirror one 84 is of the short-pass long-reverse dichroic mirror type (but not limited to long-pass short-reverse dichroic mirrors), the transmission band is ultraviolet to red, and the reflection band is near infrared.

The optional dichroic mirror 84 is circular or square in shape and is 1-9 mm in size.

The preferred mount 8 is a square body of 1-9 mm in size.

Optionally, the incoherent light guide beam 14 is a glass fiber bundle, a quartz fiber bundle or a plastic fiber bundle, a liquid optical waveguide, etc., the NA is 0.5-0.6, the optical fiber diameter is 10 micrometers to 900 micrometers, the number of the contained optical fibers is 100 hundred to 900 ten thousand, and the diameter of the incoherent light guide beam 14 is 1-9 millimeters.

Alternatively, the incoherent light source 7 is an LED, a mercury lamp, a xenon lamp, or the like, and can generate incoherent light in a single or multiple wave bands, the wave bands are ultraviolet wave bands to red wave bands, and the power is 10 milliwatts to 900 watts.

Preferably, the power of the single transverse mode narrow bandwidth laser light source is 10-900mw, and can be 20mW,50mW,200mW,400mW,600mW and the like. The single transverse mode narrow bandwidth laser diode with wavelength of 200-2000nm can be selected from 200nm,500nm,800nm,1200nm,160 nm, etc.

The NA optical fiber 2 has NA range of 0.18-0.23, and the low NA optical fiber 2 has extremely low coherence loss on the laser emitted by the single transverse mode narrow bandwidth laser 1 because of the very low NA.

As shown in fig. 6, another aspect of the present invention further provides an imaging device, where the imaging device includes an endoscopic illumination device, and an adapter 9, a dichroic mirror two 12, a camera one 10 and a camera two 11 mounted on an eye piece 42 of an endoscope 4, the adapter 9 is located between the eye piece 42 and the dichroic mirror two 12, an incident end of the dichroic mirror two 12 is coupled with the adapter 9, and an emergent end of the dichroic mirror two 12 is coupled with the camera one 10 and the camera two 11, respectively; an imaging channel 19 is arranged between the imaging end 41 and the ocular 42, a relay lens is arranged in the imaging channel, the imaging channel is used for transmitting light from the sample at the imaging end 41 to a dichroic mirror II 12, the dichroic mirror II 12 is used for dividing the light from the sample into visible light and near infrared light, and the visible light and the near infrared light are respectively used for bright field imaging and laser speckle blood flow imaging; the first camera 10 is used for receiving visible light signals scattered by incoherent light on a sample, and the second camera 11 is used for receiving laser speckle signals scattered by high-coherence laser light on the sample.

The invention provides an endoscopic lighting device, which comprises a single transverse mode narrow bandwidth laser 1, a low NA optical fiber 2, a microsphere lens 3 and an endoscope 4, wherein the single transverse mode narrow bandwidth laser 1 is used for generating high-coherence laser, the light incidence end of the low NA optical fiber 2 is directly coupled with the single transverse mode narrow bandwidth laser 1, and the microsphere lens 3 is fixed at the emergent end of the low NA optical fiber 2 so as to increase the angle of the high-coherence laser emergent from the low NA optical fiber 2; the low NA optical fiber 2 and the microsphere lens 3 are arranged around the endoscope objective lens; the laser illumination with high coherence, high coupling efficiency, high uniformity and large illumination angle under the endoscope can be realized.

In addition, the low NA optical fiber and the microsphere lens are one or more groups and are fixed around the endoscope objective lens.

Referring to fig. 7, a fourth invention of the present invention provides an electronic endoscope including a single transverse mode narrow band laser 1, a low NA optical fiber 2, and a microsphere lens 3; the single transverse mode narrow bandwidth laser 1 is used for generating a high-coherence laser light source, the light incidence end of the low NA optical fiber 2 is coupled with the single transverse mode narrow bandwidth laser 1, and the microsphere lens 3 is fixed at the emergent end of the low NA optical fiber 2 so as to increase the angle of the high-coherence laser emergent from the low NA optical fiber 2; the electronic endoscope 18 is used for receiving laser signals scattered from a sample, the electronic endoscope 18 is internally provided with a working channel 13 in addition to an imaging channel 19, the low NA optical fiber 2 and the microsphere lens 3 are both arranged in the working channel 12 of the electronic endoscope, and the microsphere lens 3 is fixed around an objective lens of the electronic endoscope 18.

This embodiment can provide high coherence, large illumination angle, high uniformity for the electronic endoscope, and such an electronic endoscope 18 has incomparable advantages in terms of size compared to a hard mirror, and better imaging quality compared to a fiberscope, so that the endoscope LSFI based on the electronic endoscope has a large application scene.

As shown in fig. 8, the fifth invention also provides an electronic endoscope, comprising a single transverse mode narrow band laser 1 and a microsphere lens 3; the imaging end of the electronic endoscope 18 is provided with a single transverse mode narrow bandwidth laser 1, the light emitting side of the single transverse mode narrow bandwidth laser 1 is coupled with a microsphere lens 3, and the microsphere lens 3 is used for expanding high-coherence laser generated by the single transverse mode narrow bandwidth laser 1; the single transverse mode narrow bandwidth laser 1 and the microsphere lens 3 are coupled to form a laser illumination module 16, and the laser illumination module 16 is provided with one or more groups.

In this embodiment, the imaging end of the electronic endoscope 18 is directly provided with the single transverse mode narrow bandwidth laser 1 and the microsphere lens 3, so that the laser emitted by the single transverse mode narrow bandwidth laser 1 can be directly shaped and expanded by the microsphere lens 3 without passing through an optical fiber, and the illumination field of view is larger than that of the electronic endoscope in the third invention.

The fourth invention also comprises an LED light source, wherein the light emitting side of the LED light source is coupled with a microsphere lens 3, and the microsphere lens 3 is used for expanding incoherent light generated in the LED light source; the LED light source and the microsphere lens 3 are coupled to form an LED lighting module 17, and one or more groups of LED lighting modules 17 are arranged; the laser illumination module 16 and the LED illumination module 17 are uniformly arranged along the circumferential direction of the imaging end of the electronic endoscope.

In addition, more laser illumination modules 16 and LED illumination modules 17 can further improve illumination uniformity (two groups of laser illumination modules 16, two groups of LED illumination modules 17, and four groups of laser illumination modules are shown in fig. 8).

Furthermore, the LED light source is used as an emission source of incoherent light, and the LED light source is suitable for being mounted at the imaging end of the electronic endoscope 18 with a small space due to the small size of the LED.

In this embodiment, the imaging end of the electronic endoscope 18 is directly provided with the LED light source and the microsphere lens 3, so that the light emitted by the LED light source can be directly shaped and expanded by the microsphere lens 3 without passing through an optical fiber, and the illumination field of view is larger than that of the electronic endoscope in the third invention.

As shown in fig. 9, the imaging end of the electronic endoscope 18 has an imaging chip 15, where the imaging chip 15 is different from a common bayer array RGB chip, and the pixel frame of the imaging chip 15 is a 4×4 pixel combined rgb+ I R chip, such as a hawk OH02A1S chip, which can implement RGB and near infrared imaging without the need for an additional dichroic mirror and a bi-directional camera scheme.

It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

The preferred embodiments of the invention disclosed above are intended only to assist in the explanation of the invention. The preferred embodiments are not exhaustive or to limit the invention to the precise form disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best understand and utilize the invention. The invention is limited only by the claims and the full scope and equivalents thereof.

Claims (12)

1. An optical endoscopic lighting device comprises a single transverse mode narrow bandwidth laser, a low NA optical fiber, a microsphere lens and an endoscope, wherein the single transverse mode narrow bandwidth laser is used for generating high-coherence laser, a light incidence end of the low NA optical fiber is directly coupled with the single transverse mode narrow bandwidth laser, and the microsphere lens is fixed at an emergent end of the low NA optical fiber so as to increase the angle of the high-coherence laser emergent from the low NA optical fiber; the illumination system of the endoscope has a light cone coupled with the microsphere lenses and an illumination fiber bundle.

2. The optical endoscopic lighting device according to claim 1, further comprising an incoherent light source, an incoherent light guide beam and a mount, the incoherent light source directing incoherent light through the incoherent light guide beam to the mount;

The device comprises a mounting seat, a first dichroic mirror, a second dichroic mirror, a first mounting seat light inlet, a second mounting seat light inlet and a microsphere lens, wherein the first dichroic mirror is fixed inside the mounting seat and is used for combining high-coherence laser and incoherent light beams, the first mounting seat light inlet, the second mounting seat light inlet and the microsphere lens are arranged outside the mounting seat, the second mounting seat light inlet is used for fixing the incoherent light beams, and the light outlet of the mounting seat is directly coupled with an endoscope light cone.

3. The optical endoscopic lighting device according to claim 2, wherein said incoherent light guide beam is a glass fiber bundle, a quartz fiber bundle, a plastic fiber bundle or a liquid light guide.

4. An optical endoscopic lighting device according to claim 2, wherein said incoherent light source is an LED, mercury lamp or xenon lamp.

5. The optical endoscopic lighting device according to any one of claims 1-4, wherein the single transverse mode narrow bandwidth laser light source has a wavelength of 200-2000nm band, a transverse modulus of 1 and a power of 10-900 mW.

6. An imaging device comprising the endoscopic illumination device of any one of claims 1-5, and an adapter mounted to an eyepiece viewing end of an endoscope, a dichroic mirror two, a camera one and a camera two, the adapter positioned between the eyepiece and the dichroic mirror two, the dichroic mirror two incident end coupled to the adapter, the dichroic mirror two exit end coupled to the camera one and the camera two, respectively;

The dichroic mirror II is used for dividing light from a sample into visible light and near infrared light, and the visible light and the near infrared light are respectively used for bright field imaging and laser speckle blood flow imaging;

The first camera is used for receiving visible light signals scattered by the incoherent light on the sample, and the second camera is used for receiving laser speckle signals scattered by the high-coherence laser on the sample.

7. An endoscopic lighting device, characterized in that: the laser comprises a single transverse mode narrow bandwidth laser, a low NA optical fiber, a microsphere lens and an endoscope, wherein the single transverse mode narrow bandwidth laser is used for generating high-coherence laser, a light incidence end of the low NA optical fiber is directly coupled with the single transverse mode narrow bandwidth laser, the microsphere lens is fixed at an emergent end of the low NA optical fiber so as to increase the angle of high-coherence laser emitted from the low NA optical fiber, and the low NA optical fiber and the microsphere lens are both arranged around an objective lens of the endoscope.

8. An endoscopic lighting device according to claim 7, wherein: the low NA optical fiber and the microsphere lens are one or more groups and are fixed around the endoscope objective lens.

9. An electronic endoscope, characterized in that: the device comprises a single transverse mode narrow-band laser, a low NA optical fiber, a microsphere lens and a working channel; the single transverse mode narrow bandwidth laser is used for generating a high-coherence laser light source, the light incidence end of the low NA optical fiber is coupled with the single transverse mode narrow bandwidth laser, and the microsphere lens is fixed at the emergent end of the low NA optical fiber so as to increase the angle of the high-coherence laser emergent from the low NA optical fiber; the low NA optical fiber and the microsphere lens are both arranged in a working channel of the electronic endoscope, and the microsphere lens is fixed around the objective lens of the electronic endoscope.

10. The electronic endoscope is characterized by comprising a single transverse mode narrow-band laser and a microsphere lens, wherein the single transverse mode narrow-band laser and the microsphere lens are arranged at an imaging end of the electronic endoscope, the microsphere lens is coupled with a light emitting side of the single transverse mode narrow-band laser, and the microsphere lens is used for expanding high-coherence laser generated by the single transverse mode narrow-band laser; the single transverse mode narrow bandwidth laser and the microsphere lens are coupled to form a laser illumination module, and one or more groups of laser illumination modules are arranged.

11. The electronic endoscope of claim 10, further comprising an LED light source, wherein a microsphere lens is coupled to the light emitting side of the LED light source, the microsphere lens for expanding incoherent light generated by the LED; the LED light source and the microsphere lens are coupled to form an LED lighting module, and one or more groups of LED lighting modules are arranged; the laser illumination modules and the LED illumination modules are uniformly arranged along the circumferential direction of the imaging end of the electronic endoscope.

12. The electronic endoscope of claim 11, wherein the imaging end of the electronic endoscope is provided with an imaging chip, the pixel frame of the imaging chip is a 4 x 4 pixel combined rgb+ir chip, and the imaging chip can perform RGB and near infrared imaging.