CN118236274A

CN118236274A - Composition with lamellar liquid crystal structure

Info

Publication number: CN118236274A
Application number: CN202410383210.7A
Authority: CN
Inventors: 吴健; 王静龙; 康燕
Original assignee: Shanghai Jahwa United Co Ltd
Current assignee: Shanghai Jahwa United Co Ltd
Priority date: 2024-03-29
Filing date: 2024-03-29
Publication date: 2024-06-25

Abstract

The invention provides a composition with a lamellar liquid crystal structure, which comprises the following components: 10-50 wt% of a surfactant; 1-12 wt% fatty acid/fatty alcohol; 1-12% by weight of glycerol laurate; and a carrier acceptable in the personal care product arts; wherein fatty acid/fatty alcohol: the weight ratio of the glycerol laurate is 1:3-2:1. The invention also relates to a preparation method of the composition with the lamellar liquid crystal structure and application of the composition in cosmetics.

Description

Composition with lamellar liquid crystal structure

Technical Field

The invention relates to the fields of colloid and surface chemistry and cosmetics, in particular to an aqueous solution system with a lamellar liquid crystal structure for personal care products, a preparation method and application thereof.

Background

The liquid crystal structure is between solid and liquid, the structure is orderly arranged, the liquid crystal has fluidity, continuity and anisotropy, and the liquid crystal has thermodynamic stability in a certain temperature range. Liquid crystals are classified into lyotropic liquid crystals and thermotropic liquid crystals, and there are 18 different structures in theory, among which lamellar liquid crystals, hexagonal liquid crystals and cubic liquid crystals are common three liquid crystal structures. In particular, the lamellar liquid crystal structure is similar to a cell membrane due to its highly ordered structure. The liquid crystal structure reduces van der Waals force among liquid drops, enhances the strength of an interface film and increases the viscosity of a system, so that the coalescence phenomenon among liquid drops in emulsion can be effectively prevented, and the system is more stable.

For example, chinese patent CN108743453a discloses a compound lamellar liquid crystal emulsifier and its application and cosmetics with lamellar liquid crystal structure, which contains three types of emulsifiers that are prone to form liquid crystals: the laminated liquid crystal structure formed by adjusting the types and the proportions of the emulsifying agents comprises the following components in parts by weight: 20-70% of higher fatty alcohol emulsifier, 10-50% of plant sterol emulsifier and 1-30% of hydrogenated soft phospholipid.

For another example, chinese patent CN103655240a discloses a liquid crystal thickener, a preparation method and application thereof, which is a surfactant modified by sodium cocoyl taurate, and requires lauric acid and myristic acid, and contains modified corn starch and polyalcohol which have liquid crystal morphology. The cream can be applied to amino acid type face cleaning systems and soap base face cleaning systems, improves the stability of cream, can suspend grease and silicone oil, and is characterized by comprising the following components in parts by weight: 1-85% of cocoyl sodium taurate, 0.1-50% of modified corn starch and lauric acid: 0.1% -30%, myristic acid: 0.1% -30% of polyol and 0% -20%.

For another example, chinese patent CN 114681334A discloses a composition containing a liquid crystal structure, a preparation method and application thereof, and the composition containing a liquid crystal structure can build a stable liquid crystal structure by itself without containing a liquid crystal emulsifier and a liquid crystal thickener, and can wrap and suspend grease, thereby achieving the effects of cleaning and cleansing at the same time, and the process is simple and easy to implement. The composite material is characterized by comprising the following components in parts by weight: amino acid surfactant: 10% -50%, fatty acid: 0% -20%, but not 0%, of a fatty acid which is lauric acid and/or myristic acid, wherein the lauric acid: 0% -20%, said myristic acid: 0-15%, polyol: 0% -30%, grease: 0% -10%, water: 10% -80%.

These prior art liquid crystal structures all use liquid crystal emulsifiers and/or thickeners that do not form stable liquid crystal structures. However, the invention innovatively develops a stable liquid crystal structure, the composition can prepare a layered liquid crystal network structure without adding a liquid crystal emulsifier and a thickening agent, the maltese cross pattern is clear, meanwhile, the composition can provide good viscosity for a system, the stability of a product is improved, and the composition is suitable for most conventional surfactants.

Disclosure of Invention

In one aspect, the present invention provides a composition having a lamellar liquid crystal structure comprising:

10-50 wt% of a surfactant;

1-12 wt% fatty acid/fatty alcohol;

1-12% by weight of glycerol laurate; and

A carrier acceptable in the personal care product arts;

wherein, fatty acid/fatty alcohol: the weight ratio of the glycerol laurate is 1:3-2:1.

In a preferred embodiment, the fatty acid/fatty alcohol is a fatty acid/fatty alcohol of C _12-16. In a preferred embodiment, the fatty acid/fatty alcohol is selected from the group consisting of: dodecanoic acid, dodecanol, tetradecanoic acid, tetradecanol, hexadecanoic acid, hexadecanol, or combinations thereof. In a preferred embodiment, the surfactant is selected from the group consisting of: anionic surfactant, amphoteric surfactant, nonionic surfactant, or combinations thereof.

In a preferred embodiment, the total amount of fatty acids/fatty alcohols and glycerol laurate in the composition is equal to or greater than 10 wt%, more preferably equal to or greater than 13 wt%. In a preferred embodiment, the fatty acid/fatty alcohol in the composition: the weight ratio of glycerol laurate is 2:1. In a preferred embodiment, the carrier is an aqueous carrier.

In another aspect, the present invention provides a method of preparing a composition having a lamellar liquid crystal structure, comprising the steps of:

(a) Mixing fatty acid/fatty alcohol, glycerol laurate and carrier;

(b) Adding a surfactant, and heating and dissolving;

(c) Cooling to obtain the liquid crystal structure composition.

In a preferred embodiment, said step (b) is heated to a temperature of 75-90 ℃.

In yet another aspect, the present invention also relates to a skin external agent comprising the composition having a lamellar liquid crystal structure. In yet another aspect, the present invention also relates to the use of a composition having a lamellar liquid crystalline structure in cosmetics.

Brief description of the drawings

FIG. 1 shows a photograph of the liquid crystal structure of the sample prepared in example 1.

Fig. 2 shows a photograph of the liquid crystal structure of the sample prepared in example 2.

FIG. 3 shows a photograph of the liquid crystal structure of the sample prepared in example 3.

FIG. 4 shows a photograph of the liquid crystal structure of the sample prepared in example 6.

Fig. 5 shows a photograph of the liquid crystal structure of the sample prepared in example 9.

FIG. 6 shows a photograph of the liquid crystal structure of the sample prepared in example 10.

FIG. 7 shows a photograph of the liquid crystal structure of the sample prepared in example 11.

FIG. 8 shows a photograph of the liquid crystal structure of the sample prepared in example 12.

Fig. 9 shows a photograph of the liquid crystal structure of the sample prepared in example 13.

Fig. 10 shows a photograph of the liquid crystal structure of the sample prepared in example 14.

FIG. 11 shows a photograph of the liquid crystal structure of the sample prepared in example 18.

FIG. 12 shows a photograph of the liquid crystal structure of the sample prepared in example 19.

Fig. 13 shows a photograph of the liquid crystal structure of the sample prepared in example 20.

Fig. 14 shows a photograph of the liquid crystal structure of the sample prepared in example 22.

Fig. 15 shows a photograph of the liquid crystal structure of the sample prepared in example 23.

FIG. 16 shows a photograph of the liquid crystal structure of the sample prepared in example 24.

Fig. 17 shows a photograph of the liquid crystal structure of the sample prepared in example 25.

Fig. 18 shows a photograph of the liquid crystal structure of the sample prepared in example 26.

Fig. 19 shows a photograph of the liquid crystal structure of the sample prepared in example 27.

Detailed Description

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are described herein. For the purposes of the present invention, the following terms are defined below.

The term "about" as used herein refers to an amount, level, value, dimension, size, or use that may differ by up to 30%, 20%, or 10% from the amount, level, value, dimension, size, or use of a reference. The percentages used herein are by weight unless otherwise indicated.

Throughout the specification and claims which follow, unless the context requires otherwise, the word "comprise", and variations such as "comprises" and "comprising", will be understood to imply the inclusion of a stated integer or step or group of integers or steps but not the exclusion of any other integer or step or group of integers or steps.

According to the present invention, the term "cosmetic" refers to a chemical industry or fine chemical product that is spread on any part of the surface of the human body, such as skin, hair, nails, lips, teeth, etc., in order to clean, maintain, beautify, modify and change the appearance, or correct the smell of the human body, in order to maintain a good state.

Composition of lamellar liquid crystal structure

The invention relates to a composition capable of forming a liquid crystal structure based on fatty acid or fatty alcohol and glycerol laurate, which has good thickening effect and good stability. The composition can be used for personal care products, and has excellent product use performance.

Compared with the prior art, the invention has the advantages that: in the presence of fatty acids or fatty alcohols: 1-12 parts of glycerol laurate: 1-12 parts of a composition: fatty acids or fatty alcohols: glycerol laurate=1:3-2:1, and the composition can form a large number of clear lamellar network structures (maltese cross) within the range, providing excellent viscosity and improving the high temperature stability of the product.

Therefore, the invention provides a novel composition containing lamellar liquid crystal, which does not need to add a liquid crystal emulsifier and/or a thickener, is applicable to most common surfactants, can prepare a lamellar liquid crystal network structure, has clear maltese cross pattern, can provide good viscosity for a system, and improves the stability of products. After the product with the liquid crystal structure is smeared on the surface layer of the skin, the product has certain advantages in improving the hydration degree of the horny layer, keeping moisture for a long time, repairing the barrier function of damaged skin and even promoting the penetration of functional substances into the horny layer compared with the conventional preparation.

The present invention provides a composition having a lamellar liquid crystal structure, the composition comprising:

10-50 wt% of a surfactant;

1-12 wt% fatty acid/fatty alcohol;

1-12% by weight of glycerol laurate; and

A carrier acceptable in the personal care product arts;

In the composition having a liquid crystal structure according to the present invention, the composition contains 20 to 50 wt% of the surfactant, preferably 25 to 50 wt%, 30 to 50 wt%, 35 to 50 wt%, 40 to 50 wt%, 45 wt% of the surfactant, based on the total weight of the composition.

In some embodiments, the surfactant is selected from the group consisting of: anionic surfactant, amphoteric surfactant, nonionic surfactant, or combinations thereof. In a specific embodiment, the surfactant is selected from the group consisting of: sodium lauroyl sarcosinate, sodium C14-16 olefin sulfonate, sodium laureth sulfate, cocamidopropyl betaine, decyl glucoside, sodium cocoyl glycinate, potassium cocoyl glycinate, or a combination thereof.

In the composition having a liquid crystal structure of the present invention, the composition contains 1 to 10% by weight of fatty acid/fatty alcohol based on the total weight of the composition.

In some embodiments, the compositions of the present invention having a liquid crystal structure comprise fatty acids/fatty alcohols of C _12-16. In some embodiments, the fatty acid/fatty alcohol is selected from the group consisting of: dodecanoic acid, dodecanol, tetradecanoic acid, tetradecanol, hexadecanoic acid, hexadecanol, or combinations thereof.

In the composition having a liquid crystal structure of the present invention, the composition contains 1 to 10% by weight of glycerol laurate, preferably 1 to 8% by weight, 1 to 6% by weight of glycerol laurate, based on the total weight of the composition.

In a preferred embodiment, the total amount of fatty acid/fatty acid alcohol and glycerol laurate in the composition of the invention having a liquid crystalline structure is not less than 10% by weight, more preferably not less than 13% by weight.

In a preferred embodiment, the weight ratio of fatty acid/fatty alcohol and glycerol laurate in the composition with liquid crystalline structure according to the invention is 3:1-1:2. In some embodiments, the weight ratio of fatty acid to glycerol laurate in the composition is 2:1.

In the present invention, the composition having a liquid crystal structure is disposed in an aqueous system. For example, the carrier employed in the composition may be any aqueous system known in the art, including but not limited to: deionized water and distilled water.

The invention also relates to a method for preparing a composition having a liquid crystal structure, said method comprising:

(a) Mixing fatty acid/fatty alcohol, glycerol laurate and carrier;

(b) Adding a surfactant, and heating and dissolving;

(c) Cooling to obtain the liquid crystal structure composition.

In some embodiments, step (b) is heated to a temperature of 75-90 ℃, preferably to 80-85 ℃.

Accordingly, the present invention provides a skin care composition having a liquid crystal structure which can be obtained by a simple preparation process, and such an aqueous system prepared according to a given formulation and preparation method has a liquid crystal structure and can provide an effective moisturizing and skin care effect.

External preparation for skin

The composition with the liquid crystal structure can be used for preparing external preparations for skin. The skin external preparation is preferably a cosmetic composition including, but not limited to, products in the form of face cream, milky lotion, jelly, lotion, essence, pack, eye cream, aerosol (cleansing foam), spray, body wash, facial cleanser, and the like.

The content of the composition having a liquid crystal structure in the skin external preparation is 0.0001 to 20% by weight, preferably 0.001 to 10% by weight, more preferably 0.01 to 5% by weight.

The external skin preparation is a general concept of all ingredients commonly used outside the skin, and may be, for example, a cosmetic composition. The cosmetic composition may be basic cosmetic, facial makeup cosmetic, body cosmetic, hair care cosmetic, etc., and its dosage form is not particularly limited and may be reasonably selected according to different purposes. The cosmetic composition also contains various cosmetically acceptable medium or matrix excipients depending on dosage form and purpose.

The skin external agent comprising the composition having a liquid crystal structure may be topically applied to human skin and/or hair. The skin external preparation may further comprise a cosmetically acceptable topical carrier, which may be about 50% to about 99.99% by weight of the skin external preparation (e.g., about 80% to about 99% by weight of the skin external preparation). In a preferred embodiment of the invention, the cosmetically acceptable topical carrier comprises water. The cosmetically acceptable topical carrier may include one or more materials selected from the group consisting of moisturizers, emollients, oils, humectants, and the like. In one embodiment, the cosmetically acceptable topical carrier includes a substrate such as a nonwoven or film material.

Skin external preparations may be formulated into a variety of product types including, but not limited to, lotions, creams, gels, sticks, sprays, ointments, cleansing liquid lotions and solid soaps, shampoos and hair conditioners, hair fixatives, pastes, foams, powders, mousses, shave creams, wipes, patches, hydrogels, film-forming products, masks and skin films, films and cosmetics such as foundations and mascaras. These product types may contain several types of cosmetically acceptable topical carriers including, but not limited to, solutions, suspensions, emulsions (e.g., microemulsions and nanoemulsions), gels, solids, and liposomes.

The external skin preparation comprising the composition having a liquid crystal structure can be formulated as a solution. The solution typically comprises an aqueous or organic solvent (e.g., about 50% to about 99.99% or about 90% to about 99% of a cosmetically acceptable aqueous or organic solvent). Examples of suitable organic solvents include propylene glycol, polyethylene glycol, polypropylene glycol, glycerol, 1,2, 4-butanetriol, sorbitol esters, 1,2, 6-hexanetriol, ethanol and mixtures thereof.

The skin external preparation may be formulated as a solution containing an emollient. Such skin external preparations preferably comprise from about 2% to about 50% of one or more emollients. As used herein, "emollient" refers to a substance used to prevent or reduce dryness, for example, by preventing the loss of skin moisture through the skin. Examples of emollients include, but are not limited to, vegetable oils, mineral oils, aliphatic esters, and the like.

Lotions can be prepared from such solutions. Lotions typically contain from about 1% to about 20% (e.g., from about 5% to about 10%) of one or more emollients and from about 50% to about 90% (e.g., from about 60% to about 80%) of moisture.

Another type of product that can be formulated from solutions is a cream. A cream typically contains from about 5% to about 50% (e.g., from about 10% to about 20%) of one or more emollients and from about 45% to about 85% (e.g., from about 50% to about 75%) of moisture.

Although it is preferable that the skin external agent comprising the composition having a liquid crystal structure comprises water, the skin external agent may alternatively be anhydrous or an ointment that does not comprise water but is an organic and/or silicone solvent, grease, lipid, and wax. Ointments may contain simple bases of animal or vegetable oils or semi-solid hydrocarbons. Ointments may contain from about 2% to about 10% of one or more emollients and from about 0.1% to about 2% of one or more thickeners.

The skin external preparation can be formulated as an emulsion. If the topical carrier is an emulsion, from about 1% to about 10% (e.g., from about 2% to about 5%) of the topical carrier contains one or more emulsifying agents. The emulsifier may be nonionic, anionic or cationic. Examples of suitable emulsifiers include those commonly identified as suitable emulsifiers in the personal care and cosmetic formulations arts.

Lotions and creams can be formulated as emulsions. Typically such lotions contain from 0.5% to about 5% of one or more emulsifying agents. Such creams typically contain from about 1% to about 20% (e.g., from about 5% to about 10%) of one or more emollients; about 20% to about 80% (e.g., 30% to about 70%) water; and from about 1% to about 10% (e.g., from about 2% to about 5%) of one or more emulsifiers.

Oil-in-water and water-in-oil single emulsion skin care formulations, such as lotions and creams, are well known in the cosmetic arts and can be used in the present invention. Multiple emulsion skin external preparations (e.g., water-in-oil-in-water and oil-in-water) are also useful in the present invention. Typically, such single-phase or multiple-phase emulsions contain moisture, emollients, and emulsifiers as their essential ingredients.

The skin external agent comprising the composition having a liquid crystal structure may also be formulated as a gel (for example, an aqueous gel, an alcoholic gel, an alcohol/water gel, or an oily gel using a suitable gelling agent). Suitable gelling agents for aqueous and/or alcoholic gels include, but are not limited to, natural gums, acrylic acid and acrylate polymers and copolymers, and cellulose derivatives (e.g., hydroxymethyl cellulose and hydroxypropyl cellulose). Suitable gellants for oils (e.g., mineral oils) include, but are not limited to, hydrogenated butene/ethylene/styrene copolymers and hydrogenated ethylene/propylene/styrene copolymers. Such gels typically contain between about 0.1% and 5% by weight of such gelling agents.

External preparations for skin comprising a composition having a liquid crystal structure may also be formulated as solid preparations (e.g., wax-based sticks, bar soaps, powders, or wipes containing powders).

In addition to the above components, the skin external preparations usable in the present invention may contain various other oil-soluble substances and/or water-soluble substances which are conventionally used in skin external preparations for use on the skin and hair at levels determined in the technical field thereof.

The skin external agent of the present invention may contain additional components commonly found in skin care compositions, such as emollients, skin conditioning agents, emulsifiers, preservatives, antioxidants, fragrances, chelating agents, and the like, as long as they are physically and chemically compatible with the other components in the skin external agent and do not affect the effects of the composition having a liquid crystal structure of the present invention.

In some embodiments of the skin external preparation of the present invention, one or more preservatives may be used. Suitable preservatives include p-hydroxyacetophenone, alkyl C1-C4 p-hydroxybenzoates and phenoxyethanol. The preservative is used in an amount of about 0.5 to about 2 wt%, preferably about 0.5 to 1 wt%, based on the total weight of the composition.

In one example of the skin external agent of the present invention, one or more antioxidants may be used. Suitable antioxidants include Butylated Hydroxytoluene (BHT), ascorbyl palmitate (BHA), butylated hydroxyanisole, phenyl-alpha-naphthylamine, hydroquinone, propyl gallate, nordihydroguaiaretic acid, vitamin E or derivatives of vitamin E, vitamin C and its derivatives, calcium pantothenate, green tea extracts and mixed polyphenols, and mixtures of the foregoing. The antioxidants are used in an amount ranging from about 0.02 to 0.5 weight percent, more preferably from about 0.002 to 0.1 weight percent, based on the total weight of the composition.

In one example of the skin external agent of the present invention, one or more emollients may be used which act as lubricants to reduce flaking and improve the appearance of the skin by their ability to remain on the skin surface or in the stratum corneum. Typical emollients include fatty esters, fatty alcohols, mineral oils, polyether siloxane copolymers, and the like. Examples of suitable emollients include, without limitation, polypropylene glycol ("PPG") -15 stearyl ether, PPG-10 cetyl ether, steareth-10, oleth-8, PPG-4 lauryl ether, vitamin E acetate, lanolin, cetyl alcohol, cetostearyl alcohol ethyl hexanoate, cetostearyl alcohol, glyceryl stearate, octyl hydroxystearate, dimethylpolysiloxane, and combinations thereof. Cetyl alcohol, cetostearyl alcohol ethyl hexanoate, cetostearyl alcohol, glycerol stearate, and combinations thereof are preferred. When used, the emollient is in an amount ranging from about 0.1 to about 30 weight percent, preferably from about 1 to about 30 weight percent, based on the total weight of the composition.

In one example of the skin external agent of the present invention, one or more moisturizers may be used. Humectants, also known as humectants, help to enhance the effectiveness of emollients, reduce flaking, stimulate removal of constituent scales and enhance skin feel. Polyols may be used as humectants including, but not limited to, glycerin, polyalkylene glycols, alkylene polyols and derivatives thereof, including butylene glycol, propylene glycol, dipropylene glycol, polyglycerol, polyethylene glycol and derivatives thereof, sorbitol, hydroxypropyl sorbitol, hexylene glycol, 1, 3-dibutylene glycol, 1,2, 6-hexanetriol, ethoxylated glycerin, propoxylated glycerin and combinations thereof. When used, the humectant is present in an amount of about 0.1 to about 20 weight percent, preferably about 1 to about 15 weight percent, based on the total weight of the composition.

In one example of the skin external agent of the present invention, one or more emulsifying agents may be used. The emulsifier may be used in an effective stabilizing amount. Preferably, the emulsifier is used in an amount of about 1.0 to about 10.0 wt%, more preferably about 3.0 to about 6.0 wt%, based on the total weight of the composition. Any emulsifier that is compatible with the components of the composition may be used. Suitable emulsifiers include stearic acid, cetyl alcohol, glyceryl stearate, lecithin, stearyl alcohol, steareth-2, steareth-20, acrylic/C10-30 alkanol acrylate cross-linked polymers, and combinations thereof.

In one example of the skin external agent of the present invention, one or more pH adjusting agents may be used. The pH adjuster useful in the skin external preparation of the present invention includes tromethamine. When used, the pH adjustor is used in an amount of about 0.1 to about 2 weight percent, preferably about 0.1 to about 1 weight percent, based on the total weight of the composition.

In one embodiment of the present invention, the skin external preparation comprises acrylic/C10-30 alkanol acrylate cross-linked polymer, glycerol, p-hydroxyacetophenone, glycerol stearate and lecithin, cetyl/stearyl alcohol, cetostearyl alcohol ethyl hexanoate, tromethamine or combinations thereof.

Examples

The invention will be further illustrated by the following examples. It is noted herein that the examples are given solely for the purpose of illustration and are not to be construed as limitations on the scope of the invention, since many insubstantial modifications and variations will become apparent to those skilled in the art in light of the above teachings. The test methods in the following examples, in which specific conditions are not specified, are generally conducted under conventional conditions or under conditions recommended by the manufacturer. All percentages and parts are by weight unless otherwise indicated.

The experimental materials used in the following examples are as follows:

Dodecanoic acid, trade name: the composition of the lauric acid, purchased from Fengyi oil technology (Lianyong) Inc.;

Tetradecanoic acid, trade name: myristic acid, purchased from the company of the oil science and technology of Fengyi (Liyun harbor);

hexadecanoic acid, trade name: c16-98MY, purchased from Emery Oleochemicals (M) Sdn Bhd;

octadecanoic acid, trade name: baomele stearic acid A9218, available from Talco brown (Zhangjihong Kong) Co., ltd;

Behenic acid, trade name: baomele stearic acid A9218, available from Talco brown (Zhangjihong Kong) Co., ltd;

cetyl alcohol, trade name: 16, available from basf (china) limited;

Sodium lauroyl sarcosinate, trade name: AMIN LS30JH new, available from Jiujiang Tiancigao New Material Co., ltd;

Sodium C14-16 olefin sulfonate, trade name: sodium alpha-alkenyl sulfonate (AOS), available from zayu technology group inc;

Sodium laureth sulfate, trade name: N70, available from basf (china) limited;

cocamidopropyl betaine, trade name: ucefactant BE-35L (K), available from Guangzhou Star technology Co., ltd;

Decyl glucoside, trade name: 2000UP, available from basf (china) limited;

sodium cocoyl glycinate, trade name: AMIN GC30U, available from new materials, inc, of new material, kyropouli;

Potassium cocoyl glycinate, trade name: AMIN GCK30H, available from Jiujiang Tiancigao New Material Co., ltd;

Glycerol laurate, trade name: 90-L12 from Basiff (China) Co.

Example 1: preparation of lauric acid and glycerol laurate composition

Weighing 10 parts by mass of dodecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 2: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 10 parts by mass of tetradecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 3: preparation of hexadecanoic acid, glycerol laurate composition

Weighing 10 parts by mass of hexadecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 4: preparation of stearic acid and glycerol laurate composition

Weighing 10 parts by mass of stearic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at a rotating speed of 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 5: preparation of behenic acid and glycerol laurate composition

Weighing 10 parts by mass of behenic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at the temperature of 85 ℃ at the speed of 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the speed of rotation to 100rpm, cooling and stirring, adjusting the speed of rotation to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 6: preparation of cetyl alcohol and glycerol laurate composition

Weighing 10 parts by mass of cetyl alcohol and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at a rotating speed of 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 7: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 5 parts by mass of tetradecanoic acid and 2.5 parts by mass of glycerol laurate, adding into a beaker containing 47.5 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath kettle at a temperature of 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, cooling to 60 ℃, adjusting the rotating speed to 50rpm, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 8: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 6 parts by mass of tetradecanoic acid and 3 parts by mass of glycerol laurate, adding into a beaker containing 46 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 9: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 6.66 parts by mass of tetradecanoic acid and 3.33 parts by mass of glycerol laurate, adding into a beaker containing 45.01 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath at 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuing cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 10: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 7.32 parts by mass of tetradecanoic acid and 3.66 parts by mass of glycerol laurate, adding into a beaker containing 44.02 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath at 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 11: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 8 parts by mass of tetradecanoic acid and 4 parts by mass of glycerol laurate, adding into a beaker containing 43 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 12: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 8.66 parts by mass of tetradecanoic acid and 4.33 parts by mass of glycerol laurate, adding into a beaker containing 42.01 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath at 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuing cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 13: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 9.33 parts by mass of tetradecanoic acid and 4.66 parts by mass of glycerol laurate, adding into a beaker containing 41.01 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath at 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuing cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 14: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 12 parts by mass of tetradecanoic acid and 6 parts by mass of glycerol laurate, adding into a beaker containing 37 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 15: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 12.5 parts by mass of tetradecanoic acid and 2.5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath kettle at 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 16: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 12 parts by mass of tetradecanoic acid and 3 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 17: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 11.75 parts by mass of tetradecanoic acid and 3.75 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath kettle at a temperature of 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, cooling to 60 ℃, adjusting the rotating speed to 50rpm, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 18: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 7.5 parts by mass of tetradecanoic acid and 7.5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath kettle at 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuing cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 19: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 5 parts by mass of tetradecanoic acid and 10 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 20: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 3.75 parts by mass of tetradecanoic acid and 11.25 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath kettle at a temperature of 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, cooling to 60 ℃, adjusting the rotating speed to 50rpm, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 21: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 2.5 parts by mass of tetradecanoic acid and 12.5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium lauroyl sarcosinate, adding into the beaker, mixing and stirring at a rotating speed of 200rpm in a water bath kettle at 85 ℃ until all the sodium lauroyl sarcosinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuing cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 22: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 10 parts by mass of tetradecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of C14-16 sodium olefin sulfonate, adding into the beaker, mixing and stirring in a water bath kettle at the temperature of 85 ℃ at the speed of 200rpm until all the sodium olefin sulfonate is dissolved, adjusting the speed of rotation to 100rpm, cooling and stirring, adjusting the speed of rotation to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 23: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 10 parts by mass of tetradecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 66 parts by mass of deionized water, weighing 19 parts by mass of sodium laureth sulfate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the sodium laureth sulfate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 24: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 10 parts by mass of tetradecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of cocamidopropyl betaine, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at 200rpm until all the cocamidopropyl betaine is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 25: preparation of tetradecanoic acid, glycerol laurate composition

10 Parts by mass of tetradecanoic acid and 5 parts by mass of glycerol laurate are weighed and added into a beaker containing 58 parts by mass of deionized water, 27 parts by mass of decyl glucoside is weighed and added into the beaker, and the mixture is mixed and stirred in a water bath kettle at the temperature of 85 ℃ at the speed of 200rpm until the mixture is completely dissolved, the rotation speed is adjusted to 100rpm, the mixture is cooled and stirred, the rotation speed is adjusted to 50rpm after the mixture is cooled to 60 ℃, the mixture is continuously cooled to 40 ℃, and the mixture is stopped; and then preserving at room temperature for later use.

Example 26: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 10 parts by mass of tetradecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of sodium cocoyl glycinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at a rotating speed of 200rpm until all the sodium cocoyl glycinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Example 27: preparation of tetradecanoic acid, glycerol laurate composition

Weighing 10 parts by mass of tetradecanoic acid and 5 parts by mass of glycerol laurate, adding into a beaker containing 40 parts by mass of deionized water, weighing 45 parts by mass of potassium cocoyl glycinate, adding into the beaker, mixing and stirring in a water bath kettle at 85 ℃ at a rotating speed of 200rpm until all the potassium cocoyl glycinate is dissolved, adjusting the rotating speed to 100rpm, cooling and stirring, adjusting the rotating speed to 50rpm after cooling to 60 ℃, continuously cooling to 40 ℃, and stopping stirring; and then preserving at room temperature for later use.

Test example: viscosity, stability and liquid crystal morphology

Viscosity meter model: RVDVS, viscosity test method: 96# rotor, 12rpm,60s.

Samples of the compositions of examples 1 to 27 of the present invention were respectively taken and placed on a glass slide, flattened with a cover glass, then observed under the light field of a light microscope under a Leica DM2700P front polarizing microscope (come, card microscopy system company), focused until emulsion particles were clearly seen, and then observed under the state of polarized light for how much, whether or not the liquid crystal was apparent and the shape of the liquid crystal, and a liquid crystal image of the sample was taken at 100 times.

The results of the viscosity, stability and liquid crystal morphology of examples 1-27 are shown in the following table.

TABLE 1

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As is clear from comparison of examples 1 to 6, examples 1,2, 3, and 6 had maltese cross liquid crystal structure under a polarizing microscope, whereas examples 4 and 5 had no maltese cross liquid crystal structure under a polarizing microscope, i.e. the kind of fatty acid or fatty alcohol was related to the formation of maltese cross liquid crystal structure.

As is clear from comparison of examples 2 and 7 to 14, examples 2, 9, 10, 11, 12, 13 and 14 have a Maltese cross liquid crystal structure under a polarizing microscope, and examples 7 and 8 have no Maltese cross liquid crystal structure under a polarizing microscope, i.e., the total amount of fatty acid and glycerol laurate is not less than 10% relative to the formation of the Maltese cross liquid crystal structure.

As is clear from comparison of examples 2, 15 to 21, examples 2, 18, 19 and 20 had a maltese cross liquid crystal structure under a polarization microscope, whereas examples 15, 16, 17 and 21 had no maltese cross liquid crystal structure under a polarization microscope, i.e. the mass ratio of fatty acid to glycerol laurate was related to the formation of maltese cross liquid crystal structure, and the mass ratio of fatty acid to glycerol laurate was 1:3 to 2:1.

As is clear from comparison of examples 2 and 22 to 27, examples 2, 22, 24, 25, 26 and 27 have maltese cross liquid crystal structure under a polarizing microscope, whereas example 23 has no maltese cross liquid crystal structure under a polarizing microscope, and has a rhombic liquid crystal structure, i.e. the kind of surfactant is related to the formation of maltese cross liquid crystal structure, and the common anionic surfactant, amphoteric surfactant and nonionic surfactant form maltese cross liquid crystal with fatty acid (fatty alcohol) and glycerol laurate.

As is clear from comparison of examples 2, 9 to 14, examples 2, 9, 10, 11, 12, 13 and 14 all have Maltese cross liquid crystal structures under a polarizing microscope, and stability of examples 2, 12, 13 and 14 is not abnormal, and stability of examples 9, 10 and 11 is layered, namely, total amount of fatty acid and glycerol laurate is related to stability of the composition, and total amount of fatty acid and glycerol laurate is not less than 13%.

As is clear from comparison of examples 2, 18 to 20, examples 2, 18, 19, 20 had a maltese cross liquid crystal structure under a polarizing microscope, and the stability was not abnormal, i.e., the mass ratio of fatty acid to glycerol laurate was related to the stability of the composition, and the mass ratio of fatty acid to glycerol laurate was 1:3 to 2:1.

As is clear from comparison of examples 2 and examples 22 to 27, examples 2, 22, 24, 25, 26 and 27 had maltese cross liquid crystal structure under a polarizing microscope, and example 23 had rhombic liquid crystal structure under a polarizing microscope, and the stability was not abnormal, i.e., the surfactant was independent of the stability of the composition.

Claims

1. A composition having a lamellar liquid crystal structure comprising:

10-50 wt% of a surfactant;

1-12 wt% fatty acid/fatty alcohol;

1-12% by weight of glycerol laurate; and

A carrier acceptable in the personal care product arts;

2. The composition of claim 1, wherein the fatty acid/fatty alcohol is a C _12-16 fatty acid/fatty alcohol.

3. The composition of claim 1, wherein the fatty acid/fatty alcohol is selected from the group consisting of: dodecanoic acid, dodecanol, tetradecanoic acid, tetradecanol, hexadecanoic acid, hexadecanol, or combinations thereof.

4. The composition of claim 1, wherein the total amount of fatty acids/fatty alcohols and glycerol laurate in the composition is equal to or greater than 10 wt%.

5. The composition of claim 4, wherein the total amount of fatty acids/fatty alcohols and glycerol laurate in the composition is equal to or greater than 13% by weight.

6. The composition of claim 1, wherein the surfactant is selected from the group consisting of: anionic surfactant, amphoteric surfactant, nonionic surfactant, or combinations thereof.

7. The composition of claim 1, wherein the fatty acid/fatty alcohol in the composition: the weight ratio of glycerol laurate is 2:1.

8. The composition of claim 1, wherein the carrier is an aqueous carrier.

9. A method for preparing the composition having a lamellar liquid crystal structure according to claim 1, comprising the steps of:

(a) Mixing fatty acid/fatty alcohol, glycerol laurate and carrier;

(b) Adding a surfactant, and heating and dissolving;

(c) Cooling to obtain the liquid crystal structure composition.

10. The method of claim 9, wherein step (b) is heated to a temperature of 75-90 ℃.

11. A skin external preparation comprising the composition according to any one of claims 1 to 8, characterized in that it further comprises a cosmetically acceptable excipient.

12. Use of a composition according to any one of claims 1 to 8 in cosmetics.