CN1181835C - Chinese medicine preparation for treating rheumatism and rheumatoid disease - Google Patents

Abstract

The present invention discloses a traditional Chinese medicine preparation for treating rheumatic diseases and rheumatoid diseases, which is prepared from earthworm, long-noded pit viper, black-tail snake, centipede, scorpion, pangolin, dragon blood, gastrodia tuber, cassia twig, angelica, ledebouriella root, notopterygium root, pubescent angelica root, achyranthes root, frankincense, myrrh, pawpaw, herba speranskiae tuberculatae, homalomena rhizoma, anisetree bark, orientvine stem, futokadsura stem, curare and licorice root as raw materials through a scientific processing technology. Because the present invention is manufactured from pure Chinese herbal medicine, the preparation has little toxic and side effect, can treat both manifestation causes and root causes of a disease, has the advantages of conspicuous curative effect and rapid clinical symptom annihilation, and has no rebounding phenomenon after healing. Therefore, the present invention is suitable for treating rheumatic diseases, rheumatoid arthritis, cervical spondylosis, shoulder periarthritis, lumbar intervertebral disc protrusion, sciatica, hyperosteogeny, etc.

Description

A kind of Chinese medicine preparation for the treatment of rheumatism, rheumatoid disease

The present invention relates to the medicine of rheumatism, rheumatoid disease, say it is to disclose a kind of Chinese medicine preparation for the treatment of rheumatism, rheumatoid disease definitely, belong to the Chinese medicine technical field.

Rheumatism, rheumatoid arthritis belong to the traditional Chinese medical science " arthromyodynia " category.The cause of disease of primary disease is battalion's deficiency of defensive qi, and space between skin and muscles is not solid, and the damp of having a cold again causes due to the passages through which vital energy circulates QI and blood impatency.In the Drug therapy process, the problem that runs into is: the state of an illness twines stupid, and Jing Jiu Bu More makes pathogen go deep into muscles and bones, and coagulation of QI-blood is not all right, and it is turbid to become the living phlegm-damp stasis of blood, and the meridians obturation is obstructed, and these product of non-vegetation can be led to, and must borrow worm Serpentis and so on search to pick and penetrate, and can open and coagulate.Medicine commonly used " controlling numbness looses ", " indometacin " etc., but easily recur after all existing drug withdrawal to some extent, grow and can lead to complications the course of treatment, and have than serious adverse.

The present invention discloses a kind of Chinese medicine preparation for the treatment of rheumatism, rheumatoid disease, and is evident in efficacy, and treating both the principal and secondary aspects of a disease is cured the no rebound phenomena in back.

Technical solution of the present invention is as follows: according to pathogeny and the Therapeutic Principle of Chinese medicine to rheumatism, rheumatoid disease, with reference to the modern medicine achievement, in the medical treasure-house of motherland, choose and have wind-expelling and dispelling dampness, activating blood circulation to dissipate blood stasis, the pure Chinese herb medicine of anti-inflammatory analgetic is made Chinese medicine preparation through science.

The present invention is made of by weight following medicine:

Pheretima 8～15, Agkistrodon 9～12, Zaocys 15～18, Scolopendra 9～12,

Scorpio 9～12, Squama Manis 12～15, Sanguis Draxonis 9～12, Rhizoma Gastrodiae 12～15,

Ramulus Cinnamomi 15～18, Radix Angelicae Sinensis 15～18, Radix Saposhnikoviae 15～18, Rhizoma Et Radix Notopterygii 12～15,

Radix Angelicae Pubescentis 12～15, Radix Achyranthis Bidentatae 12～15, Olibanum 9～12, Myrrha 9～12,

Fructus Chaenomelis 12～15, Herba speranskiae tuberculatae 15～18, Rhizoma Homalomenae 12～15, Cortex Illicii 12～15,

Caulis Sinomenii 12～15, Caulis Piperis Kadsurae 12～15, Semen Strychni (processed) 9～12, Radix Glycyrrhizae 9～12.

Preferred weight umber proportioning of the present invention is:

Pheretima 15, Agkistrodon 12, Zaocys 15, Scolopendra 12, Scorpio 9,

Squama Manis 12, Sanguis Draxonis 9, Rhizoma Gastrodiae 15, Ramulus Cinnamomi 15, Radix Angelicae Sinensis 15,

Radix Saposhnikoviae 15, Rhizoma Et Radix Notopterygii 15, Radix Angelicae Pubescentis 15, Radix Achyranthis Bidentatae 15, Olibanum 9,

Myrrha 9, Fructus Chaenomelis 15, Herba speranskiae tuberculatae 15, Rhizoma Homalomenae 15, Cortex Illicii 15,

Caulis Sinomenii 15, Caulis Piperis Kadsurae 15, Semen Strychni (processed) 12, Radix Glycyrrhizae 9.

Production method is as follows: the said medicine pulverize separately is become 80～110 order fine powders, behind the mix homogeneously, carried out the ripening sterilization treatment 10～30 minutes under 100 ℃～110 ℃, promptly get the powder medicine for the treatment of rheumatism, rheumatoid disease.

The present invention is monarch with insects medicine Scolopendra, Pheretima, Agkistrodon, Zaocys, Scorpio, Squama Manis, expelling wind and removing dampness, and it is deep to search wind; Be equipped with Sanguis Draxonis, Rhizoma Gastrodiae, Ramulus Cinnamomi, Radix Angelicae Sinensis dredge the meridian passage, blood circulation promoting and blood stasis dispelling; Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Herba speranskiae tuberculatae, Rhizoma Homalomenae, Cortex Illicii, Fructus Chaenomelis, Herba speranskiae tuberculatae, Caulis Sinomenii, Caulis Piperis Kadsurae expelling wind and removing dampness, channels sootheing and network vessel quickening are ministerial drug altogether; Assistant is with Olibanum, Myrrha, Semen Strychni (processed), promoting flow of QI and blood pain relieving; The Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

Usage and consumption: oral.Formulation rate of the present invention can be according to variations such as route of administration, patient age, body weight, disease type and the orders of severity, and daily dose is 0.01～20mg/kg.Each 2～5g, secondary took with eliminating cold for resuscitation water or yellow wine and to take after mixing it with water every day.

Attention: be not taken by pregnant women the careful usefulness of hyperpietic.

Characteristics of the present invention are: pure Chinese herbal medicine is made, toxic and side effects is little, treating both the principal and secondary aspects of a disease, evident in efficacy, clinical symptom disappearance is rapid, cure the no rebound phenomena in back, be adapted to the treatment of rheumatism, rheumatoid arthritis, cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, sciatica, hyperosteogeny diseases.

For showing the therapeutic effect of medicine of the present invention, through system's clinical observation: selected case history is divided into 2 groups at random, treatment group (A group) 147 examples, and male's 63 examples, the women 84; Age 19-68 year, average 51 years old; Rheumatic arthritis 49 examples wherein, rheumatoid arthritis 62 examples, other (as cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, sciatica, hyperosteogeny etc.) 36 examples.Matched group 128 examples are male's 59 examples wherein, and the women 69; Age 18-65 year, 48 years old mean age, rheumatic arthritis 36 examples wherein, rheumatoid arthritis 62 examples, other (as cervical spondylosis, scapulohumeral periarthritis, prolapse of lumbar intervertebral disc, sciatica, hyperosteogeny etc.) 30 examples.2 groups of cases are checked through t at aspects such as age, sex, the courses of disease, and difference does not have the significance meaning.Wherein smelting treatment group is selected said medicine for use, and matched group is selected the deep ball of vegetable garden Pai De Jin wind for use, and authentication code is defended the accurate word (1994) of medicine No. 116106 for ZZ-5433-Guangdong.

Criterion of therapeutical effect: (diagnostic criteria) carried out with reference to " the clinical research guideline of new Chinese medicine treatment numbness disease ".Clinical cure: symptom all disappears, and it is normal that functional activity recovers; Main doctor trained in Western medicine physico-chemical examination is normal.Produce effects: symptomatology disappears or main disease is eliminated, and function of joint is recovered substantially, can participate in normal work or physical labor; The physico-chemical examination index is normal substantially.Effectively: cardinal symptom disappears substantially, and main function of joint is recovered substantially or had made marked progress, and can't take care of oneself transfers to and taking care of oneself, or loses the job and work capacity is recovered to some extent; Main physical and chemical index makes moderate progress.Invalid: with the treatment before compare, each side does not all have progress.

Therapeutic outcome:

147 examples are organized in clinical total effects treatment, clinical cure 68 examples (46.3%), produce effects 42 examples (28.6%), effective 21 examples (14.3%), invalid 16 examples (10.8%), total effective rate 89.2%.Matched group 128 examples, clinical cure 31 examples (24.2%), produce effects 26 examples (20.3%), effective 19 examples (14.8%), invalid 52 examples (40.7%), total effective rate 59.3%.Two groups relatively, and the treatment group significantly is better than matched group.See the following form:

Group	Clinical cure %	Produce effects %	Effective %	Invalid %	Total effective rate (%)
						Treatment group 147	68(46.3)	42(28.6)	21(14.3)	16(10.8)	89.2
Matched group 128	31(24.2)	26(20.3)	19(14.8)	52(40.7)	59.3

Case history 1: certain woman, 39 years old, because of the morbidity of suffering from cold.Clinical symptoms: January low grade fever, weak.Extremities joint is red, swollen, bitterly, the dyskinesia, difficulty in walking.It is not good to take the ZHUIFENGTOUGU WAN symptomatic treatment.The heavy 60mm/h that has a blood test, anti-" O "＞500, the rheumatoid factor positive.Obey medicine of the present invention, each 3.5g, every day secondary, treated for 1 week after, symptom is alleviated to some extent.Symptom is obviously alleviated after 2 weeks of treatment.Check erythrocyte sedimentation rate 20mm/h after 1 month, anti-" O " and rheumatoid factor all changeed because of.Follow up a case by regular visits to and recur again for the year end 1.

Case 2: certain man, 32 years old, cadre.Went to a doctor on June 2nd, 1997, readme waist and two lower limb are sent out cold, aversion to wind, and pain is met the cold rnning play, and activity stretches that pain increases the weight of when bending not freely.Check: lift lower limb, the test of crossing one's legs, go down on one's knees is positive, muscular tone.Chemical examination: erythrocyte sedimentation rate 40mm/h, anti-" O " 1,200U, X-ray film making: no sclerotin change and anomaly.Clinical diagnosis is a rheumatic arthritis.Pain obviously alleviates after taking medicine three days, seven days hind leg temperature, and the improvement of being afraid of cold, muscle, joint motion is flexible, treats in 20 days through taking medicine, and symptom disappears substantially.Check: erythrocyte sedimentation rate 12ITun/h, anti-" O " reduces to 400U.Through following up a case by regular visits to 2 years, do not see recurrence.

Case history 3: certain man, 50 years old, cadre.The private prosecution symptom is dizzy, neck shoulder upper limb numbness 2 years.Since 96 years, worn the clothes for 5 times once, unexpected dizzy increasing the weight of when shaving, even dusk hold down ground, the portion position then takes a turn for the better after just again at once right overhead, and X-ray film shows: neck 5,6 hamate bone joint hyperosteogenys, diagnose the mixed type cervical spondylosis.Clothes and medicine of the present invention after 10 days symptom obviously alleviate, continue clothes after 20 days symptom all disappear, visit saw in 1 year unusual.

Further specify the present invention below in conjunction with embodiment:

Embodiment

Take by weighing raw material by following proportioning: Pheretima 15, Agkistrodon 12, Zaocys 15, Scolopendra 12, Scorpio 9, Squama Manis 12, Sanguis Draxonis 9, Rhizoma Gastrodiae 15, Ramulus Cinnamomi 15, Radix Angelicae Sinensis 15, Radix Saposhnikoviae 15, Rhizoma Et Radix Notopterygii 15, Radix Angelicae Pubescentis 15, Radix Achyranthis Bidentatae 15, Olibanum 9, Myrrha 9, Fructus Chaenomelis 15, Herba speranskiae tuberculatae 15, Rhizoma Homalomenae 15, Cortex Illicii 15, Caulis Sinomenii 15, Caulis Piperis Kadsurae 15, Semen Strychni (processed) 12, Radix Glycyrrhizae 9.

Production method is:

The above-mentioned raw materials pulverize separately is become 120 order fine powders, press the formula proportion mix homogeneously after, 110 ℃ of down insulations 10 minutes, then, cool to 105 ℃ of insulations 5 minutes, reduce to 100 ℃ of insulations 15 minutes again, carry out the ripening sterilization, make powder, but fill becomes capsule preparations.

Claims (2)

1, a kind of Chinese medicine preparation for the treatment of rheumatism, rheumatoid disease is characterized in that it being the medicament of being made by the following weight proportion raw material:

Pheretima 8～15, Agkistrodon 9～12, Zaocys 15～18, Scolopendra 9～12,

Scorpio 9～12, Squama Manis 12～15, Sanguis Draxonis 9～12, Rhizoma Gastrodiae 12～15,

Ramulus Cinnamomi 15～18, Radix Angelicae Sinensis 15～18, Radix Saposhnikoviae 15～18, Rhizoma Et Radix Notopterygii 12～15,

Radix Angelicae Pubescentis 12～15, Radix Achyranthis Bidentatae 12～15, Olibanum 9～12, Myrrha 9～12,

Fructus Chaenomelis 12～15, Herba speranskiae tuberculatae 15～18, Rhizoma Homalomenae 12～15, Cortex Illici difengpi 12～15,

Caulis Sinomenii 12～15, Caulis Piperis Kadsurae 12～15, Semen Strychni (processed) 9～12, Radix Glycyrrhizae 9～12.

2, Chinese medicine preparation according to claim 1 is characterized in that it being the medicament of being made by the following weight proportion raw material:

Pheretima 15, Agkistrodon 12, Zaocys 15, Scolopendra 12, Scorpio 9,

Squama Manis 12, Sanguis Draxonis 9, Rhizoma Gastrodiae 15, Ramulus Cinnamomi 15, Radix Angelicae Sinensis 15,

Radix Saposhnikoviae 15, Rhizoma Et Radix Notopterygii 15, Radix Angelicae Pubescentis 15, Radix Achyranthis Bidentatae 15, Olibanum 9,

Myrrha 9, Fructus Chaenomelis 15, Herba speranskiae tuberculatae 15, Rhizoma Homalomenae 15, Cortex Illici difengpi 15,

Caulis Sinomenii 15, Caulis Piperis Kadsurae 15, Semen Strychni (processed) 12, Radix Glycyrrhizae 9.