CN118059403A - Low-intensity focused ultrasonic nerve regulation and control monitoring system - Google Patents
Low-intensity focused ultrasonic nerve regulation and control monitoring system Download PDFInfo
- Publication number
- CN118059403A CN118059403A CN202410343084.2A CN202410343084A CN118059403A CN 118059403 A CN118059403 A CN 118059403A CN 202410343084 A CN202410343084 A CN 202410343084A CN 118059403 A CN118059403 A CN 118059403A
- Authority
- CN
- China
- Prior art keywords
- fnirs
- source
- light
- monitoring
- lifus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000012544 monitoring process Methods 0.000 title claims abstract description 55
- 210000005036 nerve Anatomy 0.000 title abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 21
- 238000002604 ultrasonography Methods 0.000 claims abstract description 19
- 210000004556 brain Anatomy 0.000 claims abstract description 17
- 239000013307 optical fiber Substances 0.000 claims abstract description 16
- 239000000523 sample Substances 0.000 claims abstract description 16
- 230000001105 regulatory effect Effects 0.000 claims abstract description 11
- 230000008569 process Effects 0.000 claims abstract description 10
- 230000004007 neuromodulation Effects 0.000 claims description 13
- 108010054147 Hemoglobins Proteins 0.000 claims description 9
- 102000001554 Hemoglobins Human genes 0.000 claims description 9
- 238000007654 immersion Methods 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 230000005284 excitation Effects 0.000 claims description 6
- 230000005540 biological transmission Effects 0.000 claims description 5
- 238000001514 detection method Methods 0.000 claims description 4
- 238000003384 imaging method Methods 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 3
- 230000031700 light absorption Effects 0.000 claims description 3
- 230000007246 mechanism Effects 0.000 claims description 3
- 238000007781 pre-processing Methods 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 2
- 230000003321 amplification Effects 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 230000008901 benefit Effects 0.000 abstract description 6
- 238000010171 animal model Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 210000003625 skull Anatomy 0.000 description 7
- 230000000638 stimulation Effects 0.000 description 7
- 238000010146 3D printing Methods 0.000 description 6
- 238000005516 engineering process Methods 0.000 description 6
- 238000002599 functional magnetic resonance imaging Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 230000008859 change Effects 0.000 description 4
- INGWEZCOABYORO-UHFFFAOYSA-N 2-(furan-2-yl)-7-methyl-1h-1,8-naphthyridin-4-one Chemical compound N=1C2=NC(C)=CC=C2C(O)=CC=1C1=CC=CO1 INGWEZCOABYORO-UHFFFAOYSA-N 0.000 description 3
- 108010064719 Oxyhemoglobins Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 210000003710 cerebral cortex Anatomy 0.000 description 3
- 108010002255 deoxyhemoglobin Proteins 0.000 description 3
- 238000002582 magnetoencephalography Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000004677 Nylon Substances 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000003925 brain function Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000006392 deoxygenation reaction Methods 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 229910044991 metal oxide Inorganic materials 0.000 description 2
- 150000004706 metal oxides Chemical class 0.000 description 2
- 229920001778 nylon Polymers 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000006213 oxygenation reaction Methods 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 1
- 238000004497 NIR spectroscopy Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002964 excitative effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
Landscapes
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Abstract
The invention discloses a low-intensity focused ultrasound nerve regulation and control monitoring system, which relates to the technical field of low-intensity focused ultrasound nerve regulation and control monitoring and comprises the following components: LIFUS regulatory sources and fNIRS monitoring sources; the LIFUS regulating source is used for transmitting ultrasonic signals to perform brain regulation; the fNIRS monitoring source monitors the brain regulation and control process; the fNIRS monitor source, comprising: optical fiber, sCMOS light receiving area array, head cap and control computer; the head cap is used for fixing the emission probe and the optical fiber probe of LIFUS regulation and control sources; the invention monitors LIFUS brain regulation and control process by fNIRS, and has the advantages of high time resolution, good real-time performance, wide applicable crowd, high comfort, safety and economy, and can be used in continuous motion.
Description
Technical Field
The invention relates to the technical field of low-intensity focused ultrasound nerve regulation and control monitoring, in particular to a low-intensity focused ultrasound nerve regulation and control monitoring system.
Background
The statements in this section merely provide background information related to the present disclosure and may not constitute prior art.
In the field of neuromodulation, low intensity focused acoustic stimulation (Low intensity focused ultrasound stimulation, LIFUS) can target cortical and deep brain regions with very high spatial specificity. LIFUS, however, is a new technique, and its stimulation parameters still lack theories. The stimulation parameters include fundamental frequency, pulse repetition frequency, duty cycle, acoustic pulse burst duration, stimulation interval time, ultrasound intensity, pulse duration, and the like. The combination of different parameters may produce different pattern effects, possibly manifested as diametrically opposed excitatory or inhibitory effects. Moreover, LIFUS have significant differences in stimulation sites, frequencies, intensities, dosages, and other parameters for different brain diseases and different disease states, and for different medication situations that a patient may be faced with, are currently facing problems that lack accurate and real-time monitoring techniques. LIFUS due to the physical particularities of the stimulating element, its monitoring technique should satisfy the following conditions: the monitoring signal is not easily interfered by the LIFU stimulus signal, the detector and the ultrasonic focusing device can not interfere with each other in space, the time/space resolution ratio, the signal to noise ratio and the like are good, and a new challenge is provided for the nerve regulation real-time monitoring technology.
Existing neuromodulation monitoring techniques can be broadly divided into two categories: firstly, by monitoring the electrical activity of the cerebral cortex, such as electroencephalogram (Electronencephalogram, EEG); secondly, functional feedback is provided by monitoring tissue oxygen changes in brain regions, such as Functional magnetic resonance imaging (Functional magnetic resonance imaging, fMRI), magnetoencephalography (Magnetoencephalogram, MEG), and Functional near infrared spectroscopy (fNIRS). However, these methods have advantages and scope of application, along with some drawbacks and limitations (see table 1).
TABLE 1 nerve regulation and control monitoring technique and advantages and disadvantages
Currently, fMRI is still a relatively accepted monitoring modality in the field of neuromodulation. However, fMRI has severe use conditions, and the acquired functional image has a delay effect and cannot be monitored in real time. Other monitoring means also have significantly shorter plates, such as EEG, with poor spatial resolution, and MEG signals are susceptible to being disturbed by LIFUS stimulus sources. fNIRS is a non-invasive brain function imaging technique that uses the absorption and scattering relationship between near infrared light and oxyhemoglobin and deoxyhemoglobin in the brain to obtain the concentration changes of oxyhemoglobin (O 2 Hb), deoxyhemoglobin (HHb) and total hemoglobin in the blood of the brain under specific conditions, thereby reflecting neural activity. Specifically, human tissue has the effect of absorbing and scattering light, and the main components of oxyhemoglobin and deoxyhemoglobin in blood have very small absorption degree of near infrared light of 700-900nm and good scattering effect. When the light source emits near infrared light with a certain power, the near infrared light is received by the detector after being absorbed and scattered by tissues, the difference between the incident light intensity and the emergent light intensity is considered to be caused by the absorption of O 2 Hb and HHHb, and the change of the concentrations of O 2 Hb and HHb can be calculated according to the modified Beer-lambert law. Compared with fMRI, fNIRS has the advantages of good ecological efficiency, high time resolution, portability, real time and lower cost, has an irreplaceable effect in the fields of infant groups and social interaction, is not easy to be interfered by a nerve control excitation source, can monitor in real time while controlling, and is an optimal monitoring means.
However, a serious shortboard of current fNIRS devices is that the spatial resolution is insufficient, typically 2-3 cm. The method is characterized in that the traditional fNIRS equipment mostly adopts a photoelectric detection technology based on an avalanche diode (APD), the spatial resolution is limited by the physical distance between an excitation light source and a detector, and the breakthrough of 2-3 cm is difficult. At present, under the great background of accurate medicine, how to improve the resolution of fNIRS breaks through the limitation of the physical distance between the traditional fNIRS excitation light source and the detector, and is a core problem of promoting fNIRS to become an accurate nerve regulation and control monitoring means.
Disclosure of Invention
The invention aims at:
(1) Aiming at the current situation that LIFUS lacks a rapid, convenient and high-time/space resolution monitoring system, the invention adopts a scientific grade complementary metal Oxide Semiconductor (sCMOS) as a fNIRS core photosensitive element; compared with the traditional APD, the sCMOS has the advantages of portability, compactness, high sensitivity, high speed, low noise, low power consumption and the like; the sensor does not need to use complex time and space coding technology, so that the physical distance limitation between the light source and the detector is hopeful to be broken through, and the spatial resolution of fNIRS is greatly improved.
(2) According to the invention, fNIRS based on sCMOS is adopted as a LIFUS brain regulation and control real-time monitoring technology, so that the defects of poor real-time performance, poor compatibility with LIFUS, inapplicability to special groups such as pregnant women and children and the like of the traditional nerve monitoring technology are overcome, and the hardware of the traditional nerve monitoring technology can be upgraded aiming at the defects of fNIRS, so that the dilemma of fNIRS low resolution is broken through, and the equipment support and research theoretical basis is provided for further realizing accurate and real-time nerve regulation and control.
The technical scheme of the invention is as follows:
A low intensity focused ultrasound neuromodulation monitoring system, comprising: LIFUS regulatory sources and fNIRS monitoring sources; the LIFUS regulating source is used for transmitting ultrasonic signals to perform brain regulation; the fNIRS monitoring source monitors the brain regulation and control process; the fNIRS monitor source, comprising: the device comprises a light source, a transmission optical fiber, an sCMOS light receiving area array, a head cap and a control computer; the head cap is used for fixing LIFUS emission probes and optical fiber probes of the regulation and control source.
Further, the LIFUS regulatory source comprises: signal generator, power amplifier, water immersion point focusing probe.
Further, the signal generator is used for generating ultrasonic signals, the power amplifier is used for amplifying the ultrasonic signals, and the water immersion point focusing probe is used for focusing and transmitting the ultrasonic signals.
Further, the water immersion point focusing probe is fixed on the head cap.
Further, the light source is used for emitting near infrared light, and the transmission optical fiber is used for transmitting the emitted near infrared light and returning scattered light signals of the cerebral cortex to the incident light source; the sCMOS light receiving area array is used for receiving scattered light signals.
Further, the fNIRS monitoring source selects 695nm and 830nm dual-wavelength light as excitation light based on a red-egg white light absorption mechanism in terms of light source selection.
Further, the fNIRS monitoring source adopts one-to-two optical fibers at the signal output end in the aspect of beam splitting, and adopts a high-transmission filter to realize the separation of signals with two wavelengths.
Furthermore, the fNIRS monitoring source adopts a high-efficiency optocoupler and a sCMOS light receiving area array with short-time exposure to collect weak light signals in the weak light detection aspect so as to improve the imaging quality.
Further, in terms of signal processing and analysis, the fNIRS monitoring source sets exposure time through sCMOS software, collects output light intensity values, and calculates oxygenation and deoxygenation hemoglobin concentration change data according to a modified Beer-Lambert law; the data is then subjected to a preprocessing step to obtain hemoglobin concentration variation data.
Further, the headgear includes: 4 fNIRS light sources, 9 fNIRS detectors, and 4 LIFU treatment areas; the types of the detector include: short pitch detector SS, intermediate pitch detector MS, long pitch detector LS.
Compared with the prior art, the invention has the beneficial effects that:
1. A low-intensity focused ultrasonic nerve regulation and control monitoring system monitors the LIFUS brain regulation and control process by fNIRS, and has the advantages of high time resolution, good real-time performance, wide applicable crowd (applicable to old people, children and pregnant women), high comfort, safety and economy, and can be used in continuous motion.
2. A low-intensity focused ultrasonic nerve regulation and control monitoring system changes a core optical detector APD used in the traditional fNIRS, adopts sCMOS as an optical detector in the system, has higher spatial resolution, reduces the volume of the system and is more portable and compact.
3. A low-intensity focused ultrasonic nerve regulation and control monitoring system adopts 3D printing to manufacture an optical fiber cap (an optical fiber cap for adapting to a rat skull in the invention) suitable for an animal model, the optical fiber cap is manufactured by three-dimensional printing by taking the rat CT skull model as a prototype, a base material is 7500 high-performance nylon material, the precision is 0.1mm, the forming size is plus or minus 0.2mm, and the optical fiber cap is different from the optical fiber cap used in the traditional fNIRS, and can be better fixed on the animal model skull to cover all brain areas of the rat.
4. A low-intensity focused ultrasound neuromodulation monitoring system acquires weakly scattered light signals by using sCMOS (scientific grade complementary metal oxide semiconductor) based area array sensors. The sensor has the characteristics of high pixel number, quick response, compactness, low cost and the like, and is suitable for multichannel scattered light collection. Through the design, multichannel scattered light signals can be effectively obtained, and the research requirement of rapid change of brain function activities in the nerve regulation and control process is met.
5. A low-intensity focused ultrasonic nerve regulation and control monitoring system uses 3D printing to manufacture an optical fiber cap suitable for an animal model, the shape of the animal model skull is well fixed on the animal model skull, and LIFUS stimulation and fNIRS signal acquisition can be synchronously carried out based on the use of the optical fiber cap, so that the strength and the signal-to-noise ratio of signals are improved.
Drawings
Fig. 1 is a schematic diagram of a low-intensity focused ultrasound neuromodulation monitoring system.
Reference numerals: 1-LIFUS of a control source, 2-fNIRS of a monitoring source, 3-control computer, 4-headgear, 5-experimental animal part, 6-fNIRS detector, 7-light source, 8-LIFUS of a treatment area, 9-short-distance detector SS, 10-intermediate-distance detector MS, 11-long-distance detector LS.
Detailed Description
It is noted that relational terms such as "first" and "second", and the like, are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
The features and capabilities of the present invention are described in further detail below in connection with examples.
Example 1
Referring to fig. 1, a low-intensity focused ultrasound neuromodulation monitoring system includes:
LIFUS regulatory sources and fNIRS monitoring sources; the LIFUS regulating source is used for transmitting ultrasonic signals to perform brain regulation; the fNIRS monitoring source monitors the brain regulation and control process; the fNIRS monitor source, comprising: the device comprises a light source, an optical fiber, an sCMOS light receiving area array, a head cap and a control computer; the head cap is used for fixing LIFUS emission probes of the control source, light sources of fNIRS and detectors.
In this embodiment, specifically, the LIFUS regulatory source includes: signal generator, power amplifier, water immersion point focusing probe.
In this embodiment, specifically, the signal generator is used for generating an ultrasonic signal, the power amplifier is used for amplifying the ultrasonic signal, and the water immersion point focusing probe is used for focusing and transmitting the ultrasonic signal.
In this embodiment, specifically, the water immersion point focusing probe is fixed on the head cap.
In this embodiment, specifically, the light source is configured to emit near infrared light, and the transmission fiber is configured to transmit the emitted near infrared light and return a scattered light signal of the cerebral cortex to the incident light source; the sCMOS light receiving area array is used for receiving scattered light signals.
In this embodiment, particularly, the fNIRS monitoring source selects 695nm and 830nm dual-wavelength light as the excitation light based on the white light absorption mechanism of hemoglobin in terms of light source selection.
In this embodiment, specifically, the fNIRS monitoring source adopts a one-to-two optical fiber at the signal output end in terms of beam splitting, and adopts a high-transmission filter to realize dual-wavelength signal separation.
In this embodiment, specifically, the fNIRS monitoring source collects weak light signals in the weak light detection aspect by using a high-efficiency optocoupler and a sCMOS light receiving area array with short-time exposure, so as to improve imaging quality.
In this embodiment, specifically, the fNIRS monitor source sets the exposure time through sCMOS software in terms of signal processing and analysis, collects the output light intensity value, and calculates the oxygenation and deoxygenation hemoglobin concentration change data according to the modified Beer-Lambert law; the data is then subjected to a preprocessing step to obtain hemoglobin concentration variation data.
In this embodiment, specifically, a 3D printing technique is used to manufacture a headgear of flexible material; the head cap suitable for the SD rat model is manufactured by 3D printing, the rat CT skull model is used as a prototype for three-dimensional printing, the base material is 7500 high-performance nylon material, the precision is 0.1mm, the forming size is plus or minus 0.2mm, and the head cap is different from the head cap used by the traditional fNIRS, and can be better fixed on the animal model skull to cover all brain areas of the rat.
In this embodiment, specifically, the headgear includes: 4 fNIRS light sources, 9 fNIRS detectors, and 4 LIFU treatment regions, approximately 1.4X1.4 cm 2 in area; the types of the detector include: short-pitch detector SS, intermediate-pitch detector MS, long-pitch detector LS; the SS detector is a short-distance detector, and the distance between the point source and the detector is 0.5cm; the MS detector is a middle distance detector, and the distance between the point source and the source detector is 1cm; the LS detector is a long-distance detector, and the distance between the point source detectors is 1.5cm. And 16 LIFU treatment regions are disposed between the detector and the light source.
The above examples merely illustrate specific embodiments of the application, which are described in more detail and are not to be construed as limiting the scope of the application. It should be noted that it is possible for a person skilled in the art to make several variants and modifications without departing from the technical idea of the application, which fall within the scope of protection of the application.
This background section is provided to generally present the context of the present invention and the work of the presently named inventors, to the extent it is described in this background section, as well as the description of the present section as not otherwise qualify as prior art at the time of filing, are neither expressly nor impliedly admitted as prior art against the present invention.
Claims (10)
1. A low intensity focused ultrasound neuromodulation monitoring system, comprising: LIFUS regulatory sources and fNIRS monitoring sources; the LIFUS regulating source is used for transmitting ultrasonic signals to perform brain regulation; the fNIRS monitoring source monitors the brain regulation and control process; the fNIRS monitor source, comprising: the device comprises a light source, a transmission optical fiber, an sCMOS light receiving area array, a head cap and a control computer; the head cap is used for fixing LIFUS emission probes of the control source and the light source and the detector of fNIRS.
2. The low intensity focused ultrasound neuromodulation monitoring system as in claim 1, wherein the LIFUS regulatory source comprises: signal generator, power amplifier, water immersion point focusing probe.
3. The low-intensity focused ultrasound neuromodulation monitoring system as in claim 2, wherein the signal generator is configured for ultrasound signal generation, the power amplifier is configured for ultrasound signal amplification, and the water immersion spot focusing probe is configured for ultrasound signal focusing and transmission.
4. The low intensity focused ultrasound neuromodulation monitoring system as in claim 2, wherein the water immersion spot focusing probe is secured to the headgear.
5. The low intensity focused ultrasound neuromodulation monitoring system of claim 1, wherein the fiber optic probe is configured to emit near infrared light and collect scattered light signals from the cortex to the point of incidence source; the sCMOS light receiving area array is used for receiving scattered light signals.
6. The system of claim 1, wherein the fNIRS monitor source selects 695nm and 830nm dual wavelength light as excitation light based on the white light absorption mechanism of hemoglobin in terms of light source selection.
7. The system of claim 1, wherein the fNIRS monitoring source is split into two parts at the signal output end and a high-pass filter is used to separate the signals of two wavelengths.
8. The system of claim 1, wherein the fNIRS monitoring sources collect weak light signals in weak light detection by using a high-efficiency optocoupler and a short-time exposure sCMOS light receiving area array to improve imaging quality.
9. The system of claim 1, wherein the fNIRS monitoring sources are configured to set exposure time by sCMOS software in terms of signal processing and analysis, collect output light intensity values, and calculate oxygenated and deoxygenated hemoglobin concentration variation data according to modified Beer-Lambert law; the data is then subjected to a preprocessing step to obtain hemoglobin concentration variation data.
10. The low intensity focused ultrasound neuromodulation monitoring system as in claim 1, wherein the headgear comprises: 4 fNIRS light sources, 9 fNIRS detectors, and 4 LIFU treatment areas; the types of the detector include: short pitch detector SS, intermediate pitch detector MS, long pitch detector LS.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410343084.2A CN118059403A (en) | 2024-03-25 | 2024-03-25 | Low-intensity focused ultrasonic nerve regulation and control monitoring system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410343084.2A CN118059403A (en) | 2024-03-25 | 2024-03-25 | Low-intensity focused ultrasonic nerve regulation and control monitoring system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN118059403A true CN118059403A (en) | 2024-05-24 |
Family
ID=91111097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410343084.2A Pending CN118059403A (en) | 2024-03-25 | 2024-03-25 | Low-intensity focused ultrasonic nerve regulation and control monitoring system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN118059403A (en) |
-
2024
- 2024-03-25 CN CN202410343084.2A patent/CN118059403A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1177565C (en) | Stethoscope | |
| US6045511A (en) | Device and evaluation procedure for the depth-selective, noninvasive detection of the blood flow and/or intra and/or extra-corporeally flowing liquids in biological tissue | |
| CN103007432B (en) | Integrated device for modulating and detecting brain functions | |
| Almajidy et al. | A newcomer's guide to functional near infrared spectroscopy experiments | |
| CN107497051B (en) | Transcranial magnetic stimulation device controlled by near infrared signals | |
| CN203001691U (en) | Integration apparatus with functions of cerebral function modulation and detection | |
| CN106037804A (en) | System for positioning brain lesion area | |
| CN111956234A (en) | Accurate blood oxygen saturation measuring method and device based on photoacoustic technology | |
| CN113197564A (en) | Portable neurovascular coupling detection device for conscious animals | |
| Bost et al. | Optoacoustic imaging of subcutaneous microvasculature with a class one laser | |
| JP4299965B2 (en) | Biological optical measurement device and optical waveguide means holding device | |
| Sonkaya | The use of functional near infrared spectroscopy technique in neurology | |
| Lacerenza et al. | Monitoring the motor cortex hemodynamic response function in freely moving walking subjects: a time-domain fNIRS pilot study | |
| Kravchuk | Mathematical model of detection of intra-erythrocyte pathologies using optoacoustic method | |
| CN118059403A (en) | Low-intensity focused ultrasonic nerve regulation and control monitoring system | |
| Avanaki et al. | High resolution functional photoacoustic computed tomography of the mouse brain during electrical stimulation | |
| CN116784841A (en) | Novel optical fiber diffusion time resolution probe system for brain-computer interface | |
| CN206063165U (en) | A kind of alignment system in brain lesionses region | |
| KR20160001890A (en) | Anti-aging skin theragnostic system using ultrasound and OCT | |
| US20150208925A1 (en) | Photoacoustic Needle Insertion Platform | |
| JP4892624B2 (en) | Biological optical measurement device and subject mounting tool used therefor | |
| BAYAZIT | The Use of Functional Near Infrared Spectroscopy Technique in the Field of Neurolinguistics | |
| CN111643110A (en) | Electroencephalogram detection device based on focused ultrasound spatial coding | |
| KR101801473B1 (en) | Apparatus for brain imaging using bundled light elements | |
| DE19838606A1 (en) | Method for non=invasive measurement of localised cerebral blood flow |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |