CN117940109A

CN117940109A - Composition for preventing bromhidrosis

Info

Publication number: CN117940109A
Application number: CN202280062267.6A
Authority: CN
Inventors: 茂吕修; 小山祥平; 旗野翠
Original assignee: Mochida Pharmaceutical Co Ltd
Current assignee: Mochida Pharmaceutical Co Ltd
Priority date: 2021-09-17
Filing date: 2022-09-16
Publication date: 2024-04-26
Also published as: WO2023042911A1

Abstract

The present invention provides a composition for preventing bromhidrosis and a composition for inhibiting the generation of malodor substances. The composition for preventing bromhidrosis contains at least 1 azole component selected from the group consisting of azoles and salts thereof, wherein the azole component content is 0.01 to 0.2 mass% based on the bromhidrosis preventing composition. A composition for inhibiting the generation of an odorous substance, which comprises at least 1 kind of azole component selected from the group consisting of azoles and salts thereof, wherein the amount of the azole component is 0.01 to 0.2% by mass based on the odorous substance generation inhibiting composition.

Description

Composition for preventing bromhidrosis

Technical Field

The present invention relates to an underarm odor preventing composition and an odor substance production inhibiting composition. More specifically, the present invention relates to an anti-bromhidrosis composition and an odor substance generation-inhibiting composition containing at least 1 azole component selected from the group consisting of azoles and salts thereof.

Background

In recent years, unpleasant feeling given to the surroundings by body odor has become a problem, and among body odor, particularly, people who mind bromhidrosis have increased. Therefore, various antiperspirants and deodorants have been marketed. In addition, an anti-bromhidrosis agent and an anti-bromhidrosis method have been developed, and patent document 1 proposes a method for preventing the generation of malodor in the armpit of a person, comprising: a bactericidal composition containing oxazole and the like is applied to the armpit.

On the other hand, patent document 2 discloses a solution for the treatment of tinea pedis, which contains terbinafine as an antifungal agent, aluminum chloride hexahydrate as an antiperspirant, and ethanol as a solvent carrier.

Prior art literature

Patent literature

Patent document 1: U.S. patent application publication No. 2003/0161799 specification

Patent document 2: japanese patent application laid-open No. 2019-526631

Disclosure of Invention

Problems to be solved by the invention

Patent document 1 does not specifically disclose the content of oxazole and the like in the bactericidal composition.

Further, document 2 is cited for the purpose of providing a composition effective for treating tinea pedis by using an antifungal agent in combination with an antiperspirant, and no means for preventing bromhidrosis or inhibiting the generation of malodor substances has been proposed. Further, the concentration of terbinafine in the above-described solution for the treatment of tinea pedis disclosed in patent document 2 is about 1%.

The purpose of the present invention is to provide a composition for preventing bromhidrosis and a composition for inhibiting the production of an odor substance.

Means for solving the problems

As a result of intensive studies to solve the above problems, the present inventors have found that underarm odor can be prevented by a small amount of an azole component, and have completed the present invention.

Further, the present inventors have found that the generation of an odor substance can be suppressed by a small amount of an azole component, and completed the present invention.

Namely, the invention relates to

[1] A composition for preventing bromhidrosis, which comprises at least 1 azole component selected from the group consisting of azoles and its salts,

The azole component is contained in an amount of 0.01 to 0.2 mass% based on the composition for preventing bromhidrosis,

[2] The composition for preventing bromhidrosis according to [1], wherein the azole is miconazole or ketoconazole,

[3] The composition for preventing bromhidrosis according to [1] or [2], which further comprises an astringent,

[4] The composition for preventing bromhidrosis according to [3], wherein the astringent is at least 1 astringent selected from the group consisting of zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid and malic acid,

[5] The composition for preventing bromhidrosis according to [3], wherein the precipitation of the azole component is suppressed,

[6] The composition for preventing bromhidrosis according to [1] or [2], which further comprises an antioxidant,

[7] The composition for preventing bromhidrosis according to [6], wherein the antioxidant is at least 1 antioxidant selected from the group consisting of tocopherol and derivatives thereof, tea extract, vitamin A and derivatives thereof, vitamin C and derivatives thereof, propyl gallate and linoleic acid,

[8] The composition for preventing bromhidrosis according to [6], wherein the precipitation of the azole component is suppressed,

[9] The composition for preventing bromhidrosis according to [1] or [2], wherein the form of the composition for preventing bromhidrosis is a form selected from the group consisting of cream, liquid, spray, stick and roll-on,

[10] A method for preventing bromhidrosis, which comprises applying the bromhidrosis preventing composition according to [1] or [2] to the axilla.

Furthermore, the invention relates to

[11] A composition for inhibiting the generation of an odorous substance, which comprises at least 1 azole component selected from the group consisting of azoles and salts thereof,

The azole component content is 0.01 to 0.2 mass% based on the composition for inhibiting the generation of malodorous substances,

[12] The composition for inhibiting the production of an odorous substance according to [11], wherein the azole is miconazole or ketoconazole,

[13] The composition for inhibiting the production of an odorant according to [11] or [12], wherein the odorant is at least 1 odorant selected from the group consisting of 3-hydroxy-3-methylhexanoic acid, 3-methyl-2-hexenoic acid, isovaleric acid, 3-methyl-3-mercaptohexane-1-ol and 3-mercapto-1-hexanol,

[14] The composition for inhibiting the production of an odorous substance as described in [11] or [12], which further comprises an astringent,

[15] The composition for inhibiting the production of an malodorous substance according to [14], wherein the astringent is at least 1 astringent selected from the group consisting of zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid and malic acid,

[16] The composition for inhibiting the production of an odorous substance according to [14], wherein the precipitation of the azole component is inhibited,

[17] The composition for inhibiting the production of an odorous substance as described in [11] or [12], which further comprises an antioxidant,

[18] The composition for inhibiting the production of an odorous substance according to [17], wherein the antioxidant is at least 1 antioxidant selected from the group consisting of tocopherol and derivatives thereof, tea extract, vitamin A and derivatives thereof, vitamin C and derivatives thereof, propyl gallate and linoleic acid,

[19] The composition for inhibiting the production of an odorous substance according to [17], wherein the precipitation of the azole component is inhibited,

[20] The composition for suppressing the production of an odorous substance as described in [11] or [12], wherein the composition for suppressing the production of an odorous substance is in a form selected from the group consisting of cream, liquid, spray, stick and roll-on,

[21] A method of suppressing the production of an odorous substance, which comprises applying the odorous substance production-suppressing composition of [11] or [12] to the axilla.

Further, the present invention relates to

[22] A method of inhibiting precipitation of an azole component comprising: at least 1 selected from zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid and malic acid are mixed in a composition for external use containing at least 1 selected from the group consisting of oxazoles and salts thereof,

[23] A method of inhibiting precipitation of an azole component comprising: at least 1 selected from tocopherol and its derivatives, tea extract, vitamin A and its derivatives, vitamin C and its derivatives, propyl gallate and linoleic acid are mixed with a topical composition containing at least 1 selected from oxazole and its salts,

[24] The method according to [22] or [23], wherein the azole is miconazole or ketoconazole,

[25] The method according to [22] or [23], wherein the external composition is in the form of a liquid,

[26] The method according to [22] or [23], wherein the composition for external use is at least 1 selected from the group consisting of an composition for preventing bromhidrosis and a composition for suppressing the generation of an odorous substance,

[27] The composition for preventing bromhidrosis according to [1], wherein at least 1 azole component selected from the group consisting of azoles and salts thereof is miconazole nitrate.

ADVANTAGEOUS EFFECTS OF INVENTION

The composition for preventing bromhidrosis of the present invention has an effect of preventing bromhidrosis.

The composition for preventing bromhidrosis of the present invention has an effect of being able to be stored stably by containing a specific astringent or a specific antioxidant.

The composition for suppressing the generation of an odorous substance of the present invention has an effect of suppressing the generation of an odorous substance.

The composition for suppressing the generation of an odorous substance of the present invention has an effect of being able to be stably stored by containing a specific astringent or a specific antioxidant.

In addition, the present invention has an effect that precipitation of an azole component during storage is suppressed by making the content of the azole component contained in the composition small.

Drawings

Fig. 1 is a graph showing the results of human sensory evaluation tests concerning the effect of preventing bromhidrosis, using the composition of example 1 and the composition of comparative example 1 in test example 1.

Fig. 2 is a graph showing the results of human sensory evaluation tests concerning the effect of preventing bromhidrosis, using the composition of example 2 and the composition of comparative example 1 in test example 1.

Fig. 3 is a graph showing the results of human sensory evaluation tests concerning the effect of preventing bromhidrosis, using the composition of example 3 and the composition of comparative example 1 in test example 1.

Fig. 4 is a graph showing the results of human sensory evaluation tests concerning the effect of preventing bromhidrosis in test example 1 using the composition of example 4 and the composition of comparative example 2.

Fig. 5 is a graph showing the results of human sensory evaluation tests concerning the effect of preventing bromhidrosis in test example 1 using the composition of example 5 and the composition of comparative example 2.

FIG. 6 is a graph showing the effect of inhibiting the production of 3-hydroxy-3-methylhexanoic acid in test example 2.

FIG. 7 is a graph showing the effect of inhibiting the production of 3-methyl-2-hexenoic acid in test example 2.

FIG. 8 is a graph showing the inhibitory effect on the production of isovaleric acid in test example 2.

FIG. 9 is a graph showing the production inhibitory effect of 3-methyl-3-mercaptohexane-1-ol in test example 2.

FIG. 10 is a graph showing the effect of inhibiting the production of 3-mercapto-1-hexanol in test example 2.

Detailed Description

[ Composition for preventing bromhidrosis ]

The present invention relates to a composition for preventing bromhidrosis, which comprises at least 1 azole component selected from the group consisting of azoles and salts thereof, wherein the azole component content is 0.01 to 0.2% by mass based on the bromhidrosis preventing composition.

The composition for preventing bromhidrosis of the present invention is used for bromhidrosis, but may be used for malodor in other parts (scalp, face, trunk, crotch, sole, etc.).

< Azole component >)

In the present invention, the azole component plays a role in preventing bromhidrosis, and is at least 1 selected from the group consisting of azole and salts thereof.

The azole component that can be used in the present invention is not particularly limited, and examples thereof include miconazole, clotrimazole, econazole, tioconazole, oxiconazole, fluconazole, itraconazole, ketoconazole, chloroconazole, noconazole, isoconazole, sulconazole, bifonazole, voriconazole, fosfluconazole, lanoconazole, chloriconazole, and salts thereof, and examples thereof include nitrate salts and hydrochloride salts.

The azole component may be used alone in an amount of 1 kind, but may be used in an amount of 2 or more kinds.

The azole component is preferably miconazole, clotrimazole, econazole, tioconazole, oxiconazole, ketoconazole, sulconazole, bifonazole, voriconazole, fosfluconazole, lanoconazole, chloriconazole or a salt thereof, more preferably miconazole, ketoconazole or a salt thereof with practical results, which is used as a drug for external use or a quasi drug, further preferably miconazole or a salt thereof, particularly preferably miconazole nitrate.

In addition, as another embodiment, ketoconazole is particularly preferable as the azole component.

Since the present invention can exhibit such an effect that the bromhidrosis can be prevented by a small amount, specifically, an azole component of 0.2 mass% or less based on the total mass of the bromhidrosis-preventing composition, the content of the azole component is 0.01 to 0.2 mass%, preferably 0.01 to 0.1 mass%, more preferably 0.03 to 0.1 mass%, and even more preferably 0.04 to 0.06 mass% based on the total mass of the bromhidrosis-preventing composition.

Astringents >

The composition for preventing bromhidrosis of the present invention may contain an astringent.

By containing the astringent, the effect of preventing bromhidrosis can be improved. In addition, the precipitation of the azole component from the composition for preventing bromhidrosis can be suppressed, and the composition for preventing bromhidrosis can be stably stored. Further, the astringent can exert a astringent effect depending on the content thereof.

Examples of astringents include zinc p-phenolsulfonate, zinc sulfate, zinc oxide and other zinc salts, aluminum chlorohydrate, allantoin aluminum chlorohydrate and other aluminum salts, alum and other metal salts, citric acid, lactic acid, tannic acid, succinic acid, malic acid, tartaric acid and other organic acids. The astringent may be used singly or in combination of 1 or 2 or more.

In the present invention, as the astringent, at least 1 selected from zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid and phosphoric acid is preferable, and at least 1 selected from zinc p-phenolsulfonate and aluminum chlorohydrate is more preferable.

In the present invention, the amount of the astringent is not particularly limited as long as it is a sufficient amount to improve the effect of preventing bromhidrosis and to stably store the bromhidrosis-preventing composition, and is preferably 0.01 to 15% by mass, more preferably 0.1 to 10% by mass, and even more preferably 0.1 to 5% by mass, based on the total mass of the bromhidrosis-preventing composition.

In the present invention, the content ratio of the azole component to the astringent is preferably 1:1 to 1000, more preferably 1:1 to 300, still more preferably 1:1 to 20, particularly preferably 1:1 to 10, in terms of mass ratio.

In the case where the astringent is zinc sulfanilate, the content ratio of the azole component to zinc sulfanilate is preferably 1:1 to 1000, more preferably 1:1 to 300, and even more preferably 1:1 to 50 in terms of mass ratio.

When the astringent is aluminum chlorohydrate, the azole component is preferably contained in a proportion of 1:1 to 1000, more preferably 1:1 to 300, and even more preferably 1:1 to 200, by mass.

< Antioxidant >

The composition for preventing bromhidrosis of the present invention may contain an antioxidant.

By containing the antioxidant, the precipitation of the azole component from the composition for preventing bromhidrosis can be suppressed, and the composition for preventing bromhidrosis can be stably stored. In addition, the antioxidant can exert an antioxidant effect according to its content.

The antioxidant may be contained without particular limitation as long as it is a substance confirming safety to the human body, and for example, sodium metabisulfite, dibutyl hydroxy toluene (BHT), butyl Hydroxy Anisole (BHA), propyl gallate, isopropyl gallate, tocopherol and its derivatives (for example, tocopherol acetate, sodium tocopheryl phosphate and the like), tea extract (for example, extract obtained by extracting green tea with water, ethanol solution, propylene glycol solution or glycerin solution and the like), vitamin a and its derivatives (for example, retinoic acid, retinol palmitate and the like), vitamin C and its derivatives (for example, ascorbic acid 2-glucoside, 3-O-ethyl ascorbic acid and the like), ferulic acid, linoleic acid, hydroquinone, astaxanthin, nicotinamide, γ -oryzanol, natural vitamin E, placenta extract and the like can be used. The antioxidant may be used singly or in an amount of 1 or 2 or more.

In the present invention, the antioxidant is preferably at least 1 selected from tocopherol and its derivatives, tea extract, vitamin a and its derivatives, vitamin C and its derivatives, propyl gallate and linoleic acid.

In the present invention, the content of the antioxidant is not particularly limited as long as it is sufficient to improve the effect of preventing bromhidrosis and to stably store the bromhidrosis-preventing composition, and is preferably 0.01 to 15% by mass, more preferably 0.05 to 10% by mass, and even more preferably 0.05 to 5% by mass, based on the total mass of the bromhidrosis-preventing composition.

In the present invention, the content ratio of the azole component to the antioxidant is preferably 1:1 to 1000, more preferably 1:1 to 300, still more preferably 1:1 to 20, particularly preferably 1:1 to 10, in terms of mass ratio.

< Other additives >)

The composition for preventing bromhidrosis of the present invention may contain, in addition to the above-mentioned components, at least 1 or more oily base, moisturizer, surfactant, alcohol, cooling agent, perfume, anti-inflammatory agent, ultraviolet absorber, antibacterial/antiseptic agent, thickener, chelating agent, pH regulator, solubilizer, cosolvent, stabilizer, pigment, powder (e.g., hydroxyapatite, etc.), adsorbent (e.g., hydroxypropyl-. Beta. -cyclodextrin, etc.), film-forming agent (e.g., (acrylate/polydimethylsiloxane) copolymer, acrylate copolymer, etc.), and the like, within a range that does not impair the object of the present invention.

As the base material of the oil-based material, examples thereof include isopropyl myristate, butyl myristate, isopropyl palmitate, butyl stearate, ethyl oleate, ethyl linoleate, isopropyl linoleate, cetyl octanoate, hexyl laurate, decyl myristate, myristyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, cetyl ricinoleate, isostearyl laurate, isotridecyl myristate, 2-hexyldecyl myristate, isostearyl myristate, 2-octyldodecyl myristate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, isostearyl palmitate, 2-ethylhexyl stearate, 2-hexyldecyl stearate, isodecyl oleate, 2-octyldodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, cetyl 2-ethylhexanoate, cetostearyl 2-ethylhexanoate, hexyl isostearate, ethylene glycol di-2-ethylhexanoate, ethylene glycol dioleate, propylene glycol dioctanoate, propylene glycol di (caprylate/caprate), propylene glycol dicaprate, propylene glycol dioleate, neopentyl glycol dicaprate, neopentyl glycol di-2-ethylhexanoate, glyceryl tricaprylate, glyceryl tri-2-ethylhexanoate, glyceryl tri (caprylate/caprate), glyceryl tri (undecanoate), glyceryl triisopalmitate, glyceryl triisostearate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexanoate, pentaerythritol tetramyristate, pentaerythritol tetraisostearate, dipentaerythritol fatty acid ester (1), 2-octyldodecyl pivalate, 2-hexyldecyl 2-ethylhexanoate, isostearyl 2-ethylhexanoate, 2-hexyldecyl dimethyloctanoate, 2-octyldodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate, 2-hexyldecyl isostearate, isostearyl isostearate, 2-octyldodecyl isostearate, lauryl lactate, myristyl lactate, cetyl lactate, 2-octyldodecyl lactate, triethyl citrate acetyltriethyl citrate, acetyltributyl citrate, tri-2-ethylhexyl citrate, triisocetyl citrate, tri-2-octyldodecyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisopropyl adipate, diisobutyl adipate, di-2-ethylhexyl adipate, diethyl sebacate, diisopropyl sebacate, di-2-ethylhexyl sebacate, dibutyl octyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, cholesteryl oleate, dihydrocholesteryl oleate, phytosterol isostearate, phytosterol oleate, isocetyl 12-stearoyl hydroxystearate, ester oils such as stearyl 12-stearoyl hydroxystearate, isostearyl 12-stearoyl hydroxystearate, polyoxyethylene (3) acetate, cetyl ether of propylene oxide, and polyoxyethylene (3) acetate, isocetylether of propylene oxide; vegetable fats and oils such as avocado oil, castor oil, hardened castor oil, olive oil, cocoa butter, camellia oil, coconut oil, wood wax, jojoba oil, and grape seed oil; hydrocarbons such as squalane, liquid paraffin, microcrystalline wax, ceresin, paraffin, and petrolatum; higher alcohols such as cetyl alcohol, stearyl alcohol, hexyldecanol, octyldodecanol, etc.; and silicones such as methylpolysiloxane, decamethylpentasiloxane and methylpolysiloxane. The oil base may be used singly or in combination of 1 or 2 or more.

In the case where the composition for preventing bromhidrosis of the present invention contains an oily base, the content of the oily base is not particularly limited as long as the effect is confirmed. The content suitable for the formulation varies, for example, with respect to the cream, and is preferably 5 to 40% by mass, more preferably 10 to 30% by mass, based on the total mass of the composition for preventing bromhidrosis.

Examples of the humectant include chondroitin sulfate, sodium chondroitin sulfate, hyaluronic acid, sodium hyaluronate, collagen, glycerin, concentrated glycerin, dipropylene glycol, propylene glycol, 1, 3-butanediol, polyethylene glycol, polyoxyethylene methyl glucoside, xylitol, sorbitol, maltitol, urea, sodium pyrrolidone carboxylate, ceramide, trimethylglycine, a plant extract, and sodium dilauryl glutamate. The humectant may be used singly in an amount of 1 or 2 or more.

In the case where the composition for preventing bromhidrosis of the present invention contains a humectant, the content of the humectant is not particularly limited as long as the content is within a range in which the effect is confirmed. For example, the total mass of the composition for preventing bromhidrosis is preferably 0.1 to 70% by mass, more preferably 1 to 50% by mass.

Examples of the surfactant include nonionic surfactants such as diglycerol monooleate, diglycerol monoisostearate, hexaglycerol pentaoleate, hexaglycerol polyricinoleate, decaglycerol pentahydroxystearate, decaglycerol pentaisostearate, decaglycerol pentaoleate, decaglycerol heptaoleate, decaglycerol polyricinoleate, monooleyl glyceryl ether, isostearyl glyceryl ether, polyoxyethylene hardened castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyglyceryl fatty acid ester, polyoxyethylene glycerol fatty acid ester, polyoxyethylene sterols, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyethylene glycol fatty acid ester, polyoxyethylene isostearate and polyoxyethylene glycerol triisostearate. The surfactant may be used singly or in an amount of 1 or 2 or more.

In the case where the composition for preventing bromhidrosis of the present invention contains a surfactant, the content of the surfactant is not particularly limited as long as the effect is confirmed. For example, the total mass of the composition for preventing bromhidrosis is preferably 0.1 to 30% by mass, more preferably 0.5 to 15% by mass.

Examples of the alcohol include lower alcohols such as ethanol, propanol, isopropanol, butanol, pentanol and hexanol, and polyhydric alcohols such as butanediol, propylene glycol (1, 2-propanediol, 1, 3-propanediol), pentanediol, hexanediol and octanediol. The alcohol may be used singly or in an amount of 1 or 2 or more.

When the composition for preventing bromhidrosis of the present invention contains an alcohol, the content of the alcohol is not particularly limited, but is preferably 1 to 80% by mass, more preferably 1 to 60% by mass, based on the total mass of the composition for preventing bromhidrosis, for example.

Examples of the cooling agent include menthol, menthyl glyceryl ether, menthyl lactate, peppermint oil, camphor, and methyl salicylate. The cooling agent may be used singly or in an amount of 1 or 2 or more.

Examples of the perfume include natural perfumes such as citral, borneol and eugenol, synthetic perfumes such as anethole, benzyl benzoate and benzyl acetate, and blended perfumes. The perfume may be used singly in 1 kind or 2 kinds or more.

Examples of the anti-inflammatory agent include salicylic acid, isopropyl methylphenol, allantoin, dipotassium glycyrrhizinate, zinc oxide, tocopheryl acetate, menthol, and the like. The anti-inflammatory agent may be used singly in an amount of 1 or 2 or more.

Examples of the ultraviolet absorber include salicylic acid-based ultraviolet absorbers, cinnamic acid-based ultraviolet absorbers, benzoylmethane-based ultraviolet absorbers, and benzoate derivative ultraviolet absorbers. The ultraviolet absorber may be used singly or in an amount of 1 or 2 or more.

Examples of the antibacterial/antiseptic agent include methyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, butyl parahydroxybenzoate, isopropyl parahydroxybenzoate, phenoxyethanol, benzoic acid, chlorhexidine gluconate, and the like. The antibacterial/antiseptic agent may be used singly 1 kind, or 2 kinds or more.

Examples of the thickener include alginic acid, carboxyvinyl polymer, guar gum, xanthan gum, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxymethyl cellulose, hydrophobic hydroxypropylmethyl cellulose, polyvinyl alcohol, bentonite, alkyl methacrylate copolymer, and (hydroxyethyl acrylate/Na acryloyldimethyl taurate) copolymer. The thickener may be used singly in an amount of 1 or 2 or more.

Examples of the chelating agent include ethylenediamine tetraacetate [ EDTA.2Na (disodium ethylenediamine tetraacetate), EDTA.3Na (trisodium ethylenediamine tetraacetate), EDTA.4Na (tetrasodium ethylenediamine tetraacetate) ], hydroxyethylphosphoric acid (hydroxyethyldiphosphonic acid), and trisodium ethylenediamine hydroxyethyl triacetate. The chelating agent may be used singly in an amount of 1 or 2 or more.

Examples of the pH adjuster include citric acid, sodium citrate, citric anhydride, succinic acid, sodium succinate, disodium succinate, phosphoric acid, sodium dihydrogen phosphate, anhydrous disodium hydrogen phosphate, lactic acid, sodium lactate, sodium hydroxide, and potassium hydroxide. The pH adjustor may be used singly in an amount of 1 or 2 or more.

The composition for preventing bromhidrosis of the present invention may contain water such as purified water and deionized water in addition to the above-mentioned components.

When the composition for preventing bromhidrosis of the present invention contains water, the content thereof is the remainder obtained by subtracting the total amount of the above components from the total amount (100 mass%) of the composition for preventing bromhidrosis.

The water content in the composition for preventing bromhidrosis of the present invention is not particularly limited, and examples thereof include 35 to 99 mass%, preferably 40 to 99 mass%, and more preferably 45 to 99 mass% based on the total mass of the composition for preventing bromhidrosis.

< Modulation method >

The method for preparing the composition for preventing bromhidrosis of the present invention is not particularly limited, and examples thereof include a method in which an azole component is mixed with any component and water as needed, and if needed, the mixture is subjected to a treatment such as heating or stirring to dissolve the components; or a method in which a solution in which an azole component is dispersed or dissolved, a solution in which an optional component is dispersed or dissolved, and the like are prepared separately, and these solutions are mixed, and if necessary, the mixture is subjected to a treatment such as heating or stirring, to dissolve the components.

The obtained composition for preventing bromhidrosis may be adjusted to a desired pH by adding the above-mentioned pH adjustor as needed.

The pH of the composition for preventing bromhidrosis of the present invention is not particularly limited, but is preferably 3 or more, more preferably 4 to 8, and still more preferably 4.5 to 7.

< Preparation form >)

Examples of the dosage form of the composition for preventing bromhidrosis of the present invention include creams, liquids, emulsions, lotions, gels, sticks, roll-ons, sprays, patches, and wiping tablets for impregnating sheets such as nonwoven fabrics with the composition for preventing bromhidrosis.

In addition, when the formulation is in an emulsified state such as cream or emulsion, the formulation may be either water-in-oil (W/O type) or oil-in-water (O/W type), and from the viewpoint of particularly good feel in use, water-in-oil (W/O type) is preferable.

In the present invention, from the viewpoint of applying/spraying the composition for preventing bromhidrosis and the like so as to be in sufficient contact with the bromhidrosis, the form of the composition for preventing bromhidrosis is preferably a cream, a liquid, a spray, a stick, or a ball, and more preferably a water-in-oil (W/O) type cream or liquid.

When the composition for preventing bromhidrosis of the present invention is formulated into a cream, the amount of the composition is usually 0.05 to 1 g/armpit, preferably 0.1 to 0.7 g/armpit.

When the composition for preventing bromhidrosis of the present invention is formulated into a liquid formulation, the coating amount thereof is usually 0.05 to 1 g/armpit, preferably 0.1 to 0.7 g/armpit.

When the composition for preventing bromhidrosis of the present invention is formulated into a spray, the amount of the composition is usually 0.05 to 1 g/armpit, preferably 0.1 to 0.7 g/armpit.

When the composition for preventing bromhidrosis of the present invention is formulated into a stick, the amount of the composition is usually 0.05 to 1 g/armpit, preferably 0.1 to 0.7 g/armpit.

When the composition for preventing bromhidrosis of the present invention is formulated into a ball preparation, the coating amount thereof is usually 0.05 to 1 g/armpit, preferably 0.1 to 0.7 g/armpit.

[ Method for preventing bromhidrosis ]

The present invention relates to a method for preventing bromhidrosis by applying the above composition for preventing bromhidrosis to the axilla.

As a method of applying the composition for preventing bromhidrosis to the axilla, there is a method of bringing the composition for preventing bromhidrosis into direct contact with the axilla by coating, spraying, or the like; and a method in which the composition for preventing bromhidrosis is brought into indirect contact with the armpit, using a sheet or the like impregnated with the composition for preventing bromhidrosis.

[ Composition for inhibiting malodor-generating substances ]

The present invention relates to a composition for inhibiting the generation of an odorous substance, which contains at least 1 kind of azole component selected from the group consisting of azoles and salts thereof, wherein the content of the azole component is 0.01 to 0.2% by mass based on the composition for inhibiting the generation of an odorous substance.

< Azole component >)

In the present invention, the azole component plays a role in suppressing the generation of malodorous substances.

The azole component contained in the composition for inhibiting the production of an malodor substance of the present invention may be the azole component described in the composition for preventing bromhidrosis.

< Odor substance >)

The malodor-imparting substance is not particularly limited, but at least 1 malodor-imparting substance selected from the group consisting of 3-hydroxy-3-methylhexanoic acid, 3-methyl-2-hexenoic acid, isovaleric acid, 3-methyl-3-mercaptohexane-1-ol and 3-mercapto-1-hexanol is preferable.

Astringents >

The composition for inhibiting the production of an malodor substance of the present invention may contain an astringent.

By containing the astringent, the effect of suppressing the generation of the odor substance can be improved. In addition, the deposition of the azole component from the composition for inhibiting the production of an odorous substance can be suppressed, and the composition for inhibiting the production of an odorous substance can be stably stored. Further, the astringent can exert a astringent effect depending on the content thereof.

As the astringent contained in the composition for inhibiting the generation of malodor substance of the present invention, the astringents described in the composition for preventing bromhidrosis can be used.

< Antioxidant >

The composition for inhibiting the production of an odorous substance of the present invention may contain an antioxidant.

By containing the antioxidant, the deposition of the azole component from the composition for suppressing the generation of an odorous substance can be suppressed, and the composition for suppressing the generation of an odorous substance can be stably stored. In addition, the antioxidant can exert an antioxidant effect according to its content.

As the antioxidant contained in the composition for inhibiting the production of an malodor substance of the present invention, the antioxidants described in the composition for preventing bromhidrosis can be used.

The composition for inhibiting the production of an malodor substance of the present invention may contain, in addition to the above-mentioned components, other additives and water described in the composition for preventing an underarm odor, within a range that does not impair the object of the present invention.

The method and the formulation of the composition for inhibiting the production of an malodor substance according to the present invention are as described in the composition for preventing bromhidrosis.

[ Method of suppressing the production of malodorous substances ]

The present invention relates to a method for suppressing the generation of an odorous substance by applying the composition for suppressing the generation of an odorous substance to the axilla.

As a method of applying the composition for suppressing the generation of an odor substance to the axilla, there is a method of bringing the composition for suppressing the generation of an odor substance into direct contact with the axilla by coating, spraying or the like; a method in which the odor substance generation-inhibiting composition is brought into indirect contact with the armpits, using a sheet or the like impregnated with the odor substance generation-inhibiting composition.

[ Method of inhibiting the precipitation of azole component ]

The invention relates to a method for inhibiting precipitation of an azole component, which comprises the following steps: at least 1 selected from zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid and malic acid is mixed with a composition for external use containing at least 1 selected from the group consisting of oxazoles and salts thereof.

The present invention also relates to a method for inhibiting precipitation of an azole component, comprising: at least 1 selected from tocopherol and its derivatives, tea extract, vitamin A and its derivatives, vitamin C and its derivatives, propyl gallate and linoleic acid are mixed with a topical composition containing at least 1 selected from oxazole and its salts.

The dosage form of the external composition is not particularly limited, but is preferably a liquid formulation.

The composition for external use is not particularly limited, but is preferably at least 1 selected from the group consisting of an anti-bromhidrosis composition and an odor-substance generation-suppressing composition.

As various components that can be used as the azole component, the astringent, and the antioxidant used in the inhibition method of the present invention, the azole component, the astringent, and the antioxidant described in the composition for preventing bromhidrosis can be used.

The method of mixing the various components that can be used as an astringent or an antioxidant in the external composition is not particularly limited, and examples thereof include a method of directly mixing the various components in the external composition, a method of mixing a solution in which the various components are dissolved or dispersed in the external composition, and the like.

Examples

The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to the examples.

Test example 1: evaluation of the effect of miconazole nitrate on preventing bromhidrosis

Compositions for preventing bromhidrosis (compositions for inhibiting malodor generation) of examples 1 to 3 (creams), examples 4 and 5 (solutions) and comparative examples 1 (creams) and 2 (solutions) were prepared according to the compositions shown in table 1 by a conventional method, and were subjected to a sensory evaluation test for evaluating the effect of preventing bromhidrosis.

Based on the odor evaluation criteria shown in table 2, 30 healthy adults with an average value of 4 to 7 of the odor of the armpit before application of the above composition for preventing bromhidrosis (composition for inhibiting the generation of an odorous substance) were extracted, and a double-blind comparison test was performed with comparative example 1 or 2 as a control. That is, the composition of example 1,2, 3, 4, or 5 was applied to one armpit of the subject, and the composition of comparative example 1 or 2 was applied to the other armpit at random, for a total of 4 days, 2 times a day and 1 time a day, with about 0.5g applied to each 1 time. The use of other anti-bromhidrosis agents and body washes containing bactericidal components was inhibited for 10 days before the start of the test. Furthermore, although the use of a shower was allowed in the test, the cleaning of the armpit was performed under supervision of the clinical facility, and was also prohibited until evaluation after 48 hours from the final coating. After 24 hours and 48 hours from the final application, 4 odor judges judged the odor of the armpit according to the odor evaluation criteria shown in table 2 below, and the average value was used. The results are shown in table 3 and fig. 1 to 5.

TABLE 1

In the table, the amounts of the respective components represent mass% based on the total mass of the composition for preventing bromhidrosis (composition for inhibiting the production of malodor substance).

TABLE 2

Table 2 odor evaluation criteria

0	No malodor at all
		1	Threshold malodor
2	Very slight malodor
		3	Slight malodor
4	Mild to moderate malodor
		5	Moderate malodor
6	Slightly strong malodor
		7	Moderate intense malodor
8	Intense malodor
		9	Very strong malodor
10	Extremely strong malodor

TABLE 3

TABLE 3 Table 3

Comparative example 1-1 is an average value of odor of an armpit after the composition of comparative example 1 was applied to one armpit, in a group of subjects having the composition of comparative example 1 applied to the other armpit.

Comparative examples 1 to 2 are average values of odor of armpits after the composition of comparative example 1 was applied to the armpits in the group of subjects having the composition of example 2 applied to one armpit and the composition of comparative example 1 applied to the other armpit.

Comparative examples 1 to 3 are average values of odor of armpits after the composition of comparative example 1 was applied to one armpit, in the group of subjects having the composition of comparative example 1 applied to the other armpit.

Comparative examples 2 to 4 are average values of odor of armpits after the composition of comparative example 2 was applied to one armpit, and the composition of comparative example 2 was applied to the other armpit, among the groups of subjects having the composition of example 4 applied to the other armpit.

Comparative examples 2 to 5 are average values of odor of armpits after the composition of comparative example 2 was applied to one armpit, and the composition of comparative example 2 was applied to the other armpit, among the groups of subjects having the composition of example 5 applied to the other armpit.

Results: the composition for preventing bromhidrosis of the present invention can be confirmed to exert an excellent bromhidrosis preventing effect. In addition, in the same human sensory evaluation test as in test example 1, the same effect of preventing bromhidrosis was confirmed by performing the test using a cream containing 0.2 mass% of miconazole nitrate.

Test example 2: production inhibition effect of malodorous substances in miconazole nitrate

The odor components were collected from the underarm of the subjects participating in test example 1 (subjects who applied the compositions of example 2 and comparative example 1 to the respective armpits) before application, 24 hours after the final application, and 48 hours after the final application, and the odor components shown below were quantified. The malodorous component is generally 5 components, namely 3-hydroxy-3-methylhexanoic acid, 3-methyl-2-hexenoic acid, isovaleric acid, 3-methyl-3-mercaptohexane-1-ol, and 3-mercapto-1-hexanol, which are considered to be the cause of bromhidrosis. The collection of gases produced from human skin uses the PFS (passive flux sampler ) method. By wearing PFS on the skin surface, volatile components generated from the skin surface diffuse within PFS and are trapped by the adsorbent incorporated into the PFS. As the adsorbent for this test, monoTrap (registered trademark) DSC18 (0.778 cm ²) manufactured by industrial corporation was used. The wearing time of the PFS was set to 2 hours, and the PFS was stored frozen or refrigerated after collection. Odor components were extracted from the adsorbent material inside the PFS, and the collected components were analyzed by a Gas Chromatography Mass Spectrometer (GCMS). The average value (+/-SE) of 26 pieces of PFS that can be recovered is shown in FIGS. 6 to 10.

Results: by compounding miconazole nitrate as an azole antifungal agent, the production of various odor components can be suppressed. The results also relate to the results of test example 1, and they revealed that azole antifungal agents such as miconazole nitrate widely inhibit the production of malodorous components and exert excellent bromhidrosis preventing effects.

Test example 3: effect of astringent ingredients on the solubility of miconazole nitrate

The composition for preventing bromhidrosis (composition for suppressing the generation of an odorous substance) was prepared so that the total amount of the mixture described in tables 4-1 and 4-2 was 100% by mass.

Specifically, miconazole nitrate was dissolved in Propylene Glycol (PG) and ethanol, and heated to about 80 ℃ as needed, and stirred with a stirrer, confirming complete dissolution of miconazole nitrate. Separately from this, a water-soluble substance containing various components that can be used as an astringent was heated to about 80 ℃ as needed, and after confirming complete dissolution of the above components, the mixture was added to a miconazole nitrate-dissolved substance. Further, purified water was added while stirring to prepare an anti-bromhidrosis composition (an odor substance generation-inhibiting composition) for each formulation. After transferring the composition for preventing bromhidrosis (composition for inhibiting the generation of malodor substance) used in the evaluation test into a sealed container made of glass, it was confirmed by visual observation that all components were completely dissolved, and then the sealed container was left for a predetermined period of time at room temperature and at 0 ℃.

The presence or absence of miconazole nitrate precipitation was determined according to the following criteria.

And (2) the following steps: needle-like crystals were not precipitated.

X: needle-like crystals precipitated.

The amounts of the respective components in the table are expressed as mass% based on the total mass of the composition for preventing bromhidrosis (composition for inhibiting the generation of malodor substances).

[ Table 4-1]

TABLE 4-2

	Prescription 8	Prescription 9	Prescription 10
				Miconazole nitrate	0.05	0.05	0.05
Propylene glycol	3	3	3
				Ethanol	20	20	20
Succinic acid	0.3
				Tartaric acid		0.3
Malic acid			0.3
				Water and its preparation method	76.65	76.65	76.65
Totalizing	100	100	100
				Stored at room temperature for 1 week	○	○	○
Preserving at 0deg.C for 1 week	○	○	○

Results: by blending aluminum chlorohydrate, citric acid, lactic acid, tannic acid, zinc p-phenolsulfonate, alum, succinic acid, tartaric acid, and malic acid, which can be used as an astringent, the precipitation of miconazole nitrate can be suppressed. That is, it was found that miconazole nitrate formulations could be stably preserved by compounding aluminum chlorohydrate, citric acid, lactic acid, tannic acid, zinc p-phenolsulfonate, alum, succinic acid, tartaric acid, and malic acid.

Test example 4: effect of antioxidant ingredient on the solubility of miconazole nitrate

An anti-bromhidrosis composition (malodor-reducing composition) was prepared so that the total amount of the mixture was 100% by mass as shown in Table 5.

Specifically, miconazole nitrate was dissolved in Propylene Glycol (PG) and ethanol, and heated to about 80 ℃ as needed, and stirred with a stirrer, so that it was confirmed that miconazole nitrate was completely dissolved. Separately from this, a water-soluble substance containing various components that can be used as an antioxidant was heated to about 80 ℃ as needed, and after confirming complete dissolution of the above components, the mixture was added to a miconazole nitrate-dissolved substance. In addition, an antioxidant which is not dissolved in water was dissolved in PG and ethanol. Further, purified water was added while stirring to prepare an anti-bromhidrosis composition (an odor substance generation-inhibiting composition) for each formulation. After transferring the composition for preventing bromhidrosis (composition for inhibiting the generation of malodor substance) used in the evaluation test to a sealed container made of glass, it was visually confirmed that all components were completely dissolved, and then the sealed container was left for a predetermined period of time at room temperature and 0 ℃.

And (2) the following steps: needle-like crystals were not precipitated.

X: needle-like crystals precipitated.

TABLE 5

Results: by compounding dl-alpha-tocopherol, d-delta-tocopherol, tocopheryl phosphate Na, tea extract, retinol palmitate, 3-O-ethyl ascorbic acid, propyl gallate and linoleic acid, which can be used as antioxidants, precipitation of miconazole nitrate can be suppressed. That is, it was found that the miconazole nitrate formulation could be stably preserved by compounding dl-alpha-tocopherol, d-delta-tocopherol, na tocopheryl phosphate, tea extract, retinol palmitate, 3-O-ethyl ascorbic acid, propyl gallate, linoleic acid, and miconazole nitrate.

Test example 5: effect of astringent ingredients on solubility of ketoconazole

An anti-bromhidrosis composition (malodor-reducing composition) was prepared so that the total amount of the mixture was 100% by mass as shown in Table 6.

Specifically, ketoconazole was dissolved in Propylene Glycol (PG) and ethanol, and heated to about 80 ℃ as needed, and stirred with a stirrer, confirming complete dissolution of ketoconazole. Separately from this, a water-soluble substance of each component that can be used as an astringent was heated to about 80 ℃ as needed, and after confirming that each component was completely dissolved, it was added to a ketoconazole-dissolved substance. Further, purified water was added while stirring to prepare an anti-bromhidrosis composition (an odor substance generation-inhibiting composition) for each formulation. After the composition for preventing bromhidrosis (composition for inhibiting the generation of an odor substance) used in the evaluation test was transferred to a glass-made sealed container, it was visually confirmed that all components were completely dissolved, and the sealed container was left for a predetermined period of time at room temperature and 0 ℃.

The presence or absence of ketoconazole deposition was determined according to the following criteria.

And (2) the following steps: needle-like crystals were not precipitated.

X: needle-like crystals precipitated.

TABLE 6

	Control	Prescription 19	Prescription 20	Prescription 21
					Ketoconazole	0.05	0.05	0.05	0.05
Propylene glycol	3	3	3	3
					Ethanol	20	20	20	20
Basic aluminum chloride		0.3
					Citric acid			0.3
P-phenol zinc sulfonate				0.3
					Water and its preparation method	76.95	76.65	76.65	76.65
Totalizing	100	100	100	100
					Stored at room temperature for 1 week	×	○	○	○
Preserving at 0deg.C for 1 week	×	○	○	○

Results: by compounding aluminum chlorohydrate, citric acid, and zinc p-phenolsulfonate, which can be used as astringents, the precipitation of ketoconazole can be suppressed. That is, it was found that the ketoconazole formulations can be stably preserved by compounding aluminum chlorohydrate, citric acid, and zinc p-phenolsulfonate.

Formulation example 1: liquid formulation

Based on the prescription shown in table 7 below, an anti-bromhidrosis composition (an odor substance generation suppressing composition) was prepared. The values in each table refer to mass%.

Miconazole nitrate, isopropyl methylphenol, zinc oxide (available in the sub-scale)), hydroxyapatite, menthol, isopropyl myristate, methyl phenyl polysiloxane, (acrylate/polydimethylsiloxane) copolymer, and acrylate copolymer were dissolved in ethanol. Further, 1, 3-butanediol, hydrophobized hydroxypropyl methylcellulose, hydroxypropyl- β -cyclodextrin, edta.2na, zinc p-phenolsulfonate, and aluminum chlorohydrate were dissolved in purified water. Further, the two components were mixed to prepare a liquid formulation for each prescription.

TABLE 7

	Prescription 22	Prescription 23	Prescription 24	Prescription 25
					Miconazole nitrate	0.05	0.05	0.05	0.05
Isopropyl methylphenol				0.05
					Zinc oxide (acidized subtype) (zinc oxide (subtype))				0.5
Hydroxyapatite	0.5
					Menthol	0.3	0.3	0.3	0.3
Myristic acid isopropyl ester	0.1
					Methyl phenyl polysiloxane	0.1
Ethanol	50	40	40	40
					(Acrylate/polydimethylsiloxane) copolymers			0.2
Acrylic ester copolymer				0.2
					1, 3-Butanediol			0.1
Hydrophobized hydroxypropyl methylcellulose	0.05	0.05	0.05	0.05
					Hydroxypropyl-beta-cyclodextrin	1	1	1	1
EDTA·2Na	0.05	0.05	0.05	0.05
					Purified water	46.85	53.55	57.25	52.8
P-phenol zinc sulfonate	1		1
					Basic aluminum chloride		5		5
Totalizing	100	100	100	100

Each preparation, miconazole nitrate, does not precipitate, can be stably stored for 1 year at room temperature, and can be stably stored for half a year at a humidity of 75% at 40 ℃.

Claims

1. A composition for preventing bromhidrosis, which comprises at least 1 azole component selected from the group consisting of azoles and its salts,

The azole component is contained in an amount of 0.01 to 0.2% by mass based on the composition for preventing bromhidrosis.

2. The composition for preventing bromhidrosis according to claim 1, wherein the azole is miconazole or ketoconazole.

3. The composition for preventing bromhidrosis according to claim 1 or 2, further comprising an astringent.

4. The composition for preventing bromhidrosis according to claim 3, wherein the astringent is at least 1 astringent selected from the group consisting of zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid and malic acid.

5. The composition for preventing bromhidrosis according to claim 3, wherein precipitation of the azole component is suppressed.

6. The composition for preventing bromhidrosis according to claim 1 or 2, further comprising an antioxidant.

7. The composition for preventing bromhidrosis according to claim 6, wherein the antioxidant is at least 1 antioxidant selected from the group consisting of tocopherol and derivatives thereof, tea extract, vitamin a and derivatives thereof, vitamin C and derivatives thereof, propyl gallate and linoleic acid.

8. The composition for preventing bromhidrosis according to claim 6, wherein precipitation of the azole component is suppressed.

9. The composition for preventing bromhidrosis according to claim 1 or 2, which is in a dosage form selected from the group consisting of cream, liquid, spray, stick and ball.

10. A method for preventing bromhidrosis, applying the bromhidrosis preventing composition according to claim 1 or 2 to the axilla.

11. A composition for inhibiting the generation of an odorous substance, which comprises at least 1 azole component selected from the group consisting of azoles and salts thereof,

The content of the azole component is 0.01 to 0.2% by mass based on the composition for inhibiting the generation of an odorous substance.

12. The composition for inhibiting the production of an odorous substance according to claim 11, wherein the azole is miconazole or ketoconazole.

13. The composition for inhibiting the production of an odorant according to claim 11 or 12, wherein the odorant is at least 1 odorant selected from the group consisting of 3-hydroxy-3-methylhexanoic acid, 3-methyl-2-hexenoic acid, isovaleric acid, 3-methyl-3-mercaptohexane-1-ol and 3-mercapto-1-hexanol.

14. The composition for inhibiting the production of an odorous substance according to claim 11 or 12, further comprising an astringent.

15. The composition for inhibiting the production of an malodorous substance according to claim 14, wherein the astringent is at least 1 astringent selected from the group consisting of zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid, and malic acid.

16. The composition for inhibiting the production of an odorous substance according to claim 14, wherein the precipitation of the azole component is inhibited.

17. The composition for inhibiting the production of an odorous substance according to claim 11 or 12, further comprising an antioxidant.

18. The composition for inhibiting the production of an odorous substance according to claim 17, wherein the antioxidant is at least 1 antioxidant selected from the group consisting of tocopherol and its derivatives, tea extract, vitamin a and its derivatives, vitamin C and its derivatives, propyl gallate and linoleic acid.

19. The composition for inhibiting the production of an odorous substance according to claim 17, wherein the precipitation of the azole component is inhibited.

20. The composition for inhibiting the production of an odorous substance according to claim 11 or 12, wherein the dosage form of the composition for inhibiting the production of an odorous substance is a dosage form selected from the group consisting of cream, liquid, spray, stick and roll-on.

21. A method of suppressing the production of an odorous substance, which comprises applying the odorous substance production-suppressing composition according to claim 11 or 12 to the axilla.

22. A method of inhibiting precipitation of an azole component comprising: at least 1 selected from zinc p-phenolsulfonate, aluminum chlorohydrate, citric acid, lactic acid, tannic acid, alum, succinic acid, tartaric acid and malic acid is mixed with a composition for external use containing at least 1 selected from the group consisting of oxazoles and salts thereof.

23. A method of inhibiting precipitation of an azole component comprising: at least 1 selected from tocopherol and its derivatives, tea extract, vitamin A and its derivatives, vitamin C and its derivatives, propyl gallate and linoleic acid are mixed with a topical composition containing at least 1 selected from oxazole and its salts.

24. The method of claim 22 or 23, wherein the azole is miconazole or ketoconazole.

25. The method of claim 22 or 23, wherein the topical composition is in the form of a liquid formulation.

26. The method according to claim 22 or 23, wherein the composition for external use is at least 1 selected from the group consisting of an composition for preventing bromhidrosis and an composition for inhibiting the production of an odorous substance.