CN117899291A - Control method, control system and application of micro pump for gas microsphere or contrast agent - Google Patents
Control method, control system and application of micro pump for gas microsphere or contrast agent Download PDFInfo
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- 239000007789 gas Substances 0.000 claims description 46
- 238000002604 ultrasonography Methods 0.000 claims description 24
- 238000012285 ultrasound imaging Methods 0.000 claims description 13
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 11
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 11
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 claims description 11
- 229960004065 perflutren Drugs 0.000 claims description 11
- 239000011261 inert gas Substances 0.000 claims description 10
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- 239000003623 enhancer Substances 0.000 claims description 5
- 230000000747 cardiac effect Effects 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 4
- 230000002708 enhancing effect Effects 0.000 claims description 4
- 238000004458 analytical method Methods 0.000 claims description 2
- 238000013500 data storage Methods 0.000 claims description 2
- 238000009795 derivation Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
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- 230000002107 myocardial effect Effects 0.000 abstract description 7
- 230000003902 lesion Effects 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
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Abstract
The invention belongs to the technical field of micropumps, and particularly relates to a control method, a control system and application of a micropump for gas microspheres or contrast agents. The control method comprises the steps of switching from rapid injection to slow injection after a certain volume is injected rapidly by adopting a micro pump; the switching process of the switching is free of time intervals. The control method and the control system for the micro pump for the gas microsphere or the contrast agent provided by the invention are simple to operate, do not need manual intervention and switching, shorten the time required by pushing injection, have small damage to the gas microsphere and uniform dosage, continuously inject the myocardial tissue contrast agent, and have good integral image quality and clear development of the effect of pushing injection contrast agent.
Description
Technical Field
The invention belongs to the technical field of micropumps, and particularly relates to a control method, a control system and application of a micropump for gas microspheres or contrast agents.
Background
Ultrasound imaging (Ultrasonic Contrast), also known as acoustic imaging (Acoustic Contrast), is a technique that uses contrast agents to enhance the backscattered echoes, significantly improving the resolution, sensitivity and specificity of ultrasound diagnosis.
The inert gas microsphere ultrasonic contrast enhancer belongs to a second generation ultrasonic contrast agent, and the contrast agent is generally used for solving the defect that conventional ultrasonic development is not clear enough, can enhance the development effect and increase the lesion recognition rate and the accuracy of lesion characterization.
The micro-injection pump (micro-pump) is matched with an ultrasonic contrast instrument to solve the defect that conventional ultrasonic development is not clear enough by adopting a specific program of inert gas microspheres, so that the development effect can be enhanced, and the lesion recognition rate and the lesion qualitative accuracy are increased.
However, the inventor found that the problems of poor development effect, complex operation and the like still exist in the ultrasonic radiography, so that a control method and a control system for a gas microsphere or a micro pump for a contrast agent, which have good development effect and simple operation, are still needed.
Disclosure of Invention
The inventor finds that most of contrast agents are manually injected during use, the problems of poor reproducibility and patient safety are easily caused, and aiming at gas microsphere ultrasonic contrast agents, if a traditional micro pump is used, manual segmented shutdown is needed for resetting speed and the like, the running speed of the traditional micro pump is single, manual intervention is needed for speed conversion, the contrast effect is poor after the time is prolonged, the operation is complex, a clinician and a nurse are needed to cooperate, the development effect is poor, the lesion recognition rate is low, and the lesion qualitative accuracy is poor.
In order to solve the technical problems, the invention provides the following technical scheme.
In a first aspect, the present invention provides a method of controlling a micropump for gas microspheres or contrast agents.
The control method of the micro pump for the gas microsphere or the contrast agent is characterized by comprising the steps of switching from rapid injection to slow injection after a certain volume is injected rapidly by adopting the micro pump; the switching process of the switching is free of time intervals.
In some embodiments, the control method includes controlling with a micropump control system that can control at least two of an injection rate, an injection volume, and an injection time of a micropump for a gas microsphere or contrast agent; after manually setting the parameters of the micropump control system or selecting the parameters of the micropump control system which are set in advance, the micropump control system controls the micropump for gas microspheres or contrast agents to be switched into slow injection after a certain volume is injected rapidly; the switching is automatically controlled by the micropump control system, and no time interval exists in the switching process; the micropump control system parameters include at least two of a fast injection volume (or referred to as a fast volume), a fast injection speed (or referred to as a fast volume), and a fast injection time, and at least two of a slow injection volume (or referred to as a slow volume), a slow injection speed (or referred to as a slow volume), and a slow injection time.
In some embodiments, the control method is used for injection of inert gas microsphere ultrasound contrast enhancing agents in ultrasound contrast.
In some embodiments, the inert gas microsphere ultrasound contrast enhancer comprises perfluoropropane human serum albumin microspheres for injection.
In some embodiments, the units of the fast injection speed or slow injection speed comprise mL/s, mL/min, mL/h, μL/s, μL/min, or L/h.
In some embodiments, the unit of fast injection volume or slow injection volume comprises L, mL or μl.
In some embodiments, the bolus injection is a constant volume injection at a rate of 0.5mL/s to 3.0mL/s (e.g., 0.5mL/s、0.6mL/s、0.7mL/s、0.8mL/s、0.9mL/s、1.0mL/s、1.1mL/s、1.2mL/s、1.3mL/s、1.4mL/s、1.5mL/s、1.6mL/s、1.7mL/s、1.8mL/s、1.9mL/s、2.0mL/s、2.1mL/s、2.2mL/s、2.3mL/s、2.4mL/s、2.5mL/s、2.6mL/s、2.7mL/s、2.8mL/s、2.9mL/s or 3.0 mL/s).
In some embodiments, the bolus injection volume is 1.5mL-12.0mL (1.5 mL, 2.0mL, 3.0mL, 4.0, 5.0mL, 6.0mL, 7.0mL, 8.0mL, 9.0mL, 10.0mL, 11.0mL, or 12.0 mL) injected at a constant rate of 0.5mL/s-3.0mL/s (e.g., 0.5mL/s、0.6mL/s、0.7mL/s、0.8mL/s、0.9mL/s、1.0mL/s、1.1mL/s、1.2mL/s、1.3mL/s、1.4mL/s、1.5mL/s、1.6mL/s、1.7mL/s、1.8mL/s、1.9mL/s、2.0mL/s、2.1mL/s、2.2mL/s、2.3mL/s、2.4mL/s、2.5mL/s、2.6mL/s、2.7mL/s、2.8mL/s、2.9mL/s or 3.0 mL/s). In some embodiments, the bolus injection volume is 3.0mL-7.5mL (3.0 mL, 4.0, 5.0mL, 6.0mL, 7.0mL, or 7.5 mL) injected at a constant rate of 0.5mL/s-3.0mL/s (e.g., 0.5mL/s、0.6mL/s、0.7mL/s、0.8mL/s、0.9mL/s、1.0mL/s、1.1mL/s、1.2mL/s、1.3mL/s、1.4mL/s、1.5mL/s、1.6mL/s、1.7mL/s、1.8mL/s、1.9mL/s、2.0mL/s、2.1mL/s、2.2mL/s、2.3mL/s、2.4mL/s、2.5mL/s、2.6mL/s、2.7mL/s、2.8mL/s、2.9mL/s or 3.0 mL/s).
In some embodiments, the slow injection volume is injected at a constant rate of 0.05mL/s to 0.15 mL/s. In some embodiments, the slow injection volume is injected at a constant rate of 0.05mL/s to 0.10 mL/s.
In some embodiments, the slow injection is a constant speed injection at a rate of 0.05mL/s to 0.15mL/s for 10s to 10min. In some embodiments, the slow injection is a constant speed injection at a rate of 0.05mL/s to 0.10mL/s for 10s to 10min.
In some preferred embodiments, the manually setting the micropump control system parameters or the built-in preset micropump control system parameters are: the fast injection volume is 6.0mL-7.5mL (adaptively adjusted to other units of fast injection volume, such as 6000 μL-7500 μL or 0.006L-0.0075L), the fast injection speed is 1.0mL/s-2.5mL/s or 2.0mL/s-2.5mL/s (adaptively adjusted to other units of fast injection speed, such as 2000 μL-2500 μL/s, 120mL/min-150mL/min or 7200 mL-9000 mL/h), the slow injection speed is 0.10mL/s-0.15mL/s (adaptively adjusted to other units of slow injection speed, such as 100 μL-150 μL/s, 6mL/min-9mL/min, 360mL/h-540 mL/h), and the slow injection time is 60s-10min (adaptively adjusted to other units of slow injection speed, such as 60s-600s or 1min-10 min).
In some preferred embodiments, the manually setting the micropump control system parameters or the built-in preset micropump control system parameters are: the fast injection volume is 6.0mL-7.5mL (adaptively adjusted to other units of fast injection volume, such as 6000 μL-7500 μL or 0.006L-0.0075L), the fast injection speed is 1.0mL/s-2.5mL/s or 2.0mL/s-2.5mL/s (adaptively adjusted to other units of fast injection volume, such as 2000 μL-2500 μL, 120 mL-150 mL/min or 7200 mL-9000 mL/h), the slow injection speed is 0.10mL/s-0.15mL/s (adaptively adjusted to other units of slow injection speed, such as 100 μL-150 μL/s, 6mL/min-9mL/min, 360mL/h-540 mL/h), and the slow injection volume is 6.0mL-90.0mL (adaptively adjusted to other units of fast injection volume, such as 6000 μL-006L or 0.9000.0.090 mL-0.15 mL).
In some preferred embodiments, the control method is used for injection of inert gas microsphere ultrasound contrast enhancing agents in ultrasound contrast; the inert gas microsphere ultrasonic contrast enhancer is perfluoropropane human serum albumin microsphere for injection; the manual setting of the parameters of the micropump control system or the built-in preset parameters of the micropump control system are as follows: the fast injection volume is 6.0mL-7.5mL (adaptively adjusted to other units of fast injection volume, such as 6000 μL-7500 μL or 0.006L-0.0075L), the fast injection speed is 1.0mL/s-2.5mL/s or 2.0mL/s-2.5mL/s (adaptively adjusted to other units of fast injection speed, such as 2000 μL-2500 μL/s, 120mL/min-150mL/min or 7200 mL-9000 mL/h), the slow injection speed is 0.10mL/s-0.15mL/s (adaptively adjusted to other units of slow injection speed, such as 100 μL-150 μL/s, 6mL/min-9mL/min, 360mL/h-540 mL/h), and the slow injection time is 60s-10min (adaptively adjusted to other units of slow injection speed, such as 60s-600s or 1min-10 min).
In some preferred embodiments, the control method is used for injection of inert gas microsphere ultrasound contrast enhancing agents in ultrasound contrast; the inert gas microsphere ultrasonic contrast enhancer is perfluoropropane human serum albumin microsphere for injection; the manual setting of the parameters of the micropump control system or the built-in preset parameters of the micropump control system are as follows: the fast injection volume is 6.0mL-7.5mL (adaptively adjusted to other units of fast injection volume, such as 6000 μL-7500 μL or 0.006L-0.0075L), the fast injection speed is 1.0mL/s-2.5mL/s or 2.0mL/s-2.5mL/s (adaptively adjusted to other units of fast injection volume, such as 2000 μL-2500 μL, 120 mL-150 mL/min or 7200 mL-9000 mL/h), the slow injection speed is 0.10mL/s-0.15mL/s (adaptively adjusted to other units of slow injection speed, such as 100 μL-150 μL/s, 6mL/min-9mL/min, 360mL/h-540 mL/h), and the slow injection volume is 6.0mL-90.0mL (adaptively adjusted to other units of fast injection volume, such as 6000 μL-006L or 0.9000.0.090 mL-0.15 mL).
In some embodiments, the fast injection volume is 6.0mL-7.5mL, the fast injection speed is 5000mL/h, the slow injection speed is 250mL/h, the slow injection time is 60s-10min, and the micropump control system parameters are applicable to a GE ultrasound imaging instrument; or alternatively
In some embodiments, the fast injection volume is 6.0mL-7.5mL, the fast injection speed is 5000mL/h, the slow injection speed is 350mL/h, the slow injection time is 60s-10min, and the micropump control system parameters are applicable to PHILIPS ultrasonic imaging apparatus.
In some embodiments, the control method includes employing a rechargeable battery as the power source.
In some embodiments, the control method includes using alternating current or direct current as a power source.
In some embodiments, the control method includes using alternating current or direct current as a power source; when the alternating current is suddenly powered off, the direct current power supply automatically switches the power supply without affecting the current executing operation.
In a second aspect, the present invention provides a micropump control system for gas microspheres or contrast agents.
A micropump control system for gas microspheres or contrast agents, the micropump control system according to the first aspect.
In a third aspect, the present invention provides a micropump for gas microspheres or contrast agents.
A micropump for gas microspheres or contrast agents comprising a control using the control method of the first aspect or comprising a micropump control system for gas microspheres or contrast agents of the second aspect.
In some embodiments, the gas microsphere or contrast agent micropump includes a data storage module, a result analysis module, and a result derivation module.
In some embodiments, the micropump for gas microspheres or contrast agents further comprises an alarm system comprising at least one of an alarm when not running according to a set parameter, an alarm when bolus is blocked, an alarm when running is over time abnormal, an alarm when pump speed is abnormal, an alarm when internal power is low, an alarm when injection is complete, an alarm when syringe identification is abnormal, an alarm when syringe falls off, an alarm when medical fluid is about to be exhausted, and an alarm when medical fluid is exhausted.
In a fourth aspect, the present invention provides a control method according to the first aspect, a micropump control system according to the second aspect or a micropump for gas microspheres or contrast agents according to the third aspect.
The control method according to the first aspect, the micropump control system according to the second aspect or the micropump for gas microspheres or contrast agent according to the third aspect is used for improving the ultrasound contrast development effect. In some embodiments, the ultrasound contrast is cardiac ultrasound enhanced visualization.
In a fifth aspect, the present invention provides a method of ultrasound imaging.
An ultrasound contrast method comprising ultrasound contrast with a micropump using the control method of the first aspect, the micropump control system of the second aspect, or the gas microsphere or contrast agent of the third aspect.
In some embodiments, the ultrasound contrast is cardiac ultrasound enhanced visualization.
In some embodiments, the ultrasound imaging method comprises performing ultrasound imaging after diluting the gas microspheres or contrast agent with the control method of the first aspect, the micropump control system of the second aspect, or the micropump of the third aspect.
In some embodiments, the ultrasound imaging method comprises performing ultrasound imaging after diluting the gas microspheres or contrast agent to 15mL-30mL using the control method of the first aspect, the micropump control system of the second aspect, or the gas microspheres or contrast agent of the third aspect with a micropump.
Advantageous effects
Compared with the prior art, one embodiment of the invention at least comprises the following beneficial effects:
(1) Compared with manual injection, the micropump control method, the micropump control system for the gas microspheres or the contrast agents or the micropump for the gas microspheres or the contrast agents can automatically switch the speed and the volume of quick pushing and slow pushing, is simple to operate, does not need manual intervention for switching, shortens the time required by injection, has small damage to the gas microspheres and uniform dosage, ensures continuous injection of the myocardial tissue contrast agents, and has good overall image quality of the injection contrast agents and clear development.
(2) Compared with other micropump control system parameters, the micropump control system parameters provided by the invention are beneficial to improving the overall image quality of the contrast agent injection effect.
Definition of terms:
the term "and/or" is understood to mean any one of the selectable items or a combination of any two or more of the selectable items.
The term "multiple" means a number of 2 or more, for example 2,3, 4 or 5, etc.
In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
Drawings
Fig. 1 shows the effect of bolus contrast for parameter (i) of example 1.
FIG. 2 shows the effect of bolus contrast for parameter (ii) of example 1.
Fig. 3 shows the bolus contrast effect of comparative example 1.
FIG. 4 shows the contrast effect of example 1 parameter (ii) at 2min from the start of bolus injection.
Fig. 5 shows the contrast effect of comparative example 1 at 2min after the start of bolus injection.
Detailed Description
The following examples are further illustrative of the invention and are not intended to limit the scope of the invention.
All technical terms used herein have the same meaning as commonly understood by one skilled in the art to which the present invention pertains. As used herein, "and"/"or" includes any and all combinations of one or more of the associated listed items.
Reagents and instrumentation:
perfluoropropane human serum albumin microsphere for injection (manufacturer: lipuggares pharmaceutical Co., ltd.; trade name: lidamycin; specification: 0.5 g/bottle).
The micropumps used in examples 1 and 2 below include those for gas microspheres or contrast agents including a micropump control system that can control the injection speed, injection volume, and injection time of the micropump for gas microspheres or contrast agents; the micro pump control system controls the micro pump for gas microsphere or contrast agent to be switched into slow injection after a certain volume is injected fast by manually setting the micro pump control system parameters or by internally arranging the micro pump control system parameters which are preset; the switching is automatically controlled by the micropump control system, and no time interval exists in the switching process; the micropump control system parameters include at least two of a fast injection volume, a fast injection speed and an injection time, and at least two of a slow injection volume, a slow injection speed and a slow injection.
Example 1: the effect of injecting contrast medium by adopting the micropump of the invention
The operation is as follows:
The volunteer takes left lateral lying position (convenient for heart ultrasonic examination), and respectively injects the perfluoropropane human serum albumin microsphere for contrast agent injection into the back vein of the right upper limb of the volunteer according to the following micropump control system parameters (1 bottle of perfluoropropane human serum albumin microsphere for injection is diluted to 15mL by normal saline and is injected by adopting the parameter (i), or 1 bottle of perfluoropropane human serum albumin microsphere for injection is diluted to 30mL by normal saline and is injected by adopting the parameter (i)), heart ultrasonic radiography is carried out after the injection is started, and heart ultrasonic examination is completed in the injection process:
(i) The fast injection volume is 6mL, the fast injection speed is 2mL/s, the slow injection volume is 9mL, the slow injection speed is 0.1mL/s, and the slow injection time is 90s; or alternatively
(Ii) The fast injection volume was 6mL, the fast injection rate was 2mL/s, the slow injection volume was 24mL, the slow injection rate was 0.1mL/s, and the slow injection time was 240s.
Results:
(1) The result of the parameter (i) is shown in fig. 1 and fig. 4, the result of the parameter (ii) is shown in fig. 2, the micro pump or the micro pump control system provided by the invention can automatically switch the speed and the volume of quick pushing and slow pushing, is simple to operate, does not need manual intervention for switching, shortens the time required by pushing injection, has small damage to gas microspheres and uniform dosage, ensures continuous injection of myocardial tissue contrast agent, has good overall image quality of the effect of pushing injection contrast agent, and is clear in development.
(2) With the bolus mode of the present invention (e.g., parameter (ii)), myocardial tissue contrast continues to perfuse at 2min after the start of the bolus, with long duration of contrast.
Comparative example 1: hand-push contrast agent effect
The operation is as follows:
1 bottle of perfluoropropane human serum albumin microsphere for injection is diluted to 30mL by normal saline to obtain contrast agent solution, a volunteer takes a left lateral position (convenient for heart ultrasonic examination), 6mL of contrast agent solution is manually injected into the vein of the right upper limb and the back of the hand of the volunteer at an injection speed of about 2mL/s, and heart ultrasonic examination is completed in the injection process.
Results: referring to fig. 3 and 5, the method of pushing the contrast agent is complex in operation, long in time required for pushing and uneven in dosage, so that the myocardial tissue contrast agent is not perfused, and the obtained image is poor in overall image quality, unstable and uneven in development. As is clear from fig. 5, the myocardial tissue contrast medium was not injected at the 2 nd minute after the start of the bolus injection by using the hand-push contrast medium, and the contrast effect duration was short.
Example 2: parameter investigation of micropump control system
The operation is as follows:
diluting 1 bottle of perfluoropropane human serum albumin microsphere for injection to 30mL by using normal saline to obtain a contrast agent solution, taking a left lateral position (convenient for heart ultrasonic examination) by a volunteer, respectively injecting the perfluoropropane human serum albumin microsphere for contrast agent injection into the volunteer according to the following micropump control system parameters, and carrying out heart ultrasonic radiography after the injection is completed:
Conclusion:
(1) Compared with manual injection, the micro pump or the micro pump control system provided by the invention can automatically switch the speed and the volume of quick pushing and slow pushing, is simple to operate, does not need manual intervention for switching, shortens the time required by injection, has small damage to gas microspheres and uniform dosage, ensures continuous injection of myocardial tissue contrast agent, and has good overall image quality and clear development of the injection contrast agent effect.
(2) Compared with other micropump control system parameters, the injection parameters provided by the invention are beneficial to improving the overall image quality of the effect of injecting the contrast agent.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The control method of the micro pump for the gas microsphere or the contrast agent is characterized by comprising the steps of switching from rapid injection to slow injection after a certain volume is injected rapidly by adopting the micro pump; the switching process of the switching is free of time intervals.
2. The control method according to claim 1, comprising controlling with a micropump control system that can control at least two of an injection speed, an injection volume, and an injection time of a micropump for a gas microsphere or a contrast agent; after manually setting the parameters of the micropump control system or selecting the parameters of the micropump control system which are set in advance, the micropump control system controls the micropump for gas microspheres or contrast agents to be switched into slow injection after a certain volume is injected rapidly; the switching is automatically controlled by the micropump control system, and no time interval exists in the switching process; the micropump control system parameters include at least two of a fast injection volume, a fast injection speed and a fast injection time, and at least two of a slow injection volume, a slow injection speed and a slow injection time.
3. A control method according to any one of claims 1-2 for the injection of inert gas microsphere ultrasound contrast enhancing agents in ultrasound contrast; and/or
The inert gas microsphere ultrasonic contrast enhancer comprises perfluoropropane human serum albumin microspheres for injection; and/or
The unit of the fast injection speed or the slow injection speed comprises mL/s, mL/min, mL/h, mu L/s, mu L/min or L/h; and/or
The unit of the fast injection volume or the slow injection volume comprises L, mL or mu L;
And/or
The quick injection of a certain volume is to inject a certain volume at a constant speed of 0.5-3.0 mL/s; or the rapid injection is performed at a constant speed of 1.5mL-12.0mL or 3.0mL-7.5mL at a speed of 0.5mL/s-3.0 mL/s; or the rapid injection is 6.0mL-7.5mL at a constant speed of 2.0mL/s-2.5 mL/s;
And/or
The slow injection is injection at a constant speed of 0.05mL/s-0.15mL/s or 0.05mL/s-0.10 mL/s; or the slow injection is performed at a constant speed of 0.05-0.15 mL/s for 10s-10min; or the slow injection is 6.0-90.0 mL at a constant speed of 0.10-0.15 mL/s.
4. The control method according to claim 2, wherein the manually setting the micropump control system parameters or the built-in preset micropump control system parameters is:
The quick injection volume is 6.0mL-7.5mL, the quick injection speed is 1.0mL/s-2.5mL/s or 2.0mL/s-2.5mL/s, the slow injection speed is 0.10mL/s-0.15mL/s, and the slow injection time is 60s-10min; or alternatively
The rapid injection volume is 6.0mL-7.5mL, the rapid injection speed is 1.0mL/s-2.5mL/s or 2.0mL/s-2.5mL/s, the slow injection speed is 0.10mL/s-0.15mL/s, and the slow injection volume is 6.0mL-90.0mL or 6.0mL-24.0mL; or alternatively
The rapid injection volume is 6.0mL-7.5mL, the rapid injection speed is 5000mL/h, the slow injection speed is 250mL/h, and the slow injection time is 60s-10min, and the device is suitable for a GE ultrasonic development instrument; or alternatively
The quick injection volume is 6.0mL-7.5mL, the quick injection speed is 5000mL/h, the slow injection speed is 350mL/h, and the slow injection time is 60s-10min, and the method is suitable for PHILIPS ultrasonic developing instruments.
5. The control method according to any one of claims 1 to 4, comprising using a rechargeable battery as a power source; and/or
The control method comprises the steps of adopting alternating current or direct current as a power supply; and/or
The control method comprises the steps of adopting alternating current or direct current as a power supply, and automatically switching the direct current power supply to supply power when the alternating current is suddenly powered off, so that the current and subsequent execution operations are not affected.
6. A micropump control system for gas microspheres or contrast agents, characterized in that the micropump control system is according to any one of claims 1-7.
7. A micropump for gas microspheres or contrast agents comprising a control according to any one of claims 1-5 or comprising a micropump control system for gas microspheres or contrast agents according to claim 6.
8. The micropump for gas microspheres or contrast agents of claim 7 further comprising a data storage module, a result analysis module, and a result derivation module; and/or
The micro pump for the gas microsphere or the contrast agent further comprises an alarm system, wherein the alarm system comprises at least one of an alarm when the micro pump is not operated according to set parameters, an alarm when the bolus is blocked, an alarm when the operation end time is abnormal, an alarm when the rotation speed of the pump is abnormal, an alarm when an internal power supply is low, an alarm when the injection is completed, an alarm when the injector is identified to be abnormal, an alarm when the injector falls off, an alarm when the liquid medicine is about to be exhausted and an alarm when the liquid medicine is exhausted.
9. Use of a control method according to any one of claims 1 to 5, a micropump control system for gas microspheres or contrast agents according to claim 6 or a micropump for gas microspheres or contrast agents according to any one of claims 7 to 8 for improving the development effect of ultrasound contrast;
optionally, the ultrasound contrast is cardiac ultrasound enhanced visualization.
10. A method of ultrasound imaging comprising performing ultrasound imaging using the control method of any one of claims 1 to 5, the micropump control system for gas microspheres or contrast agents of claim 6, or the micropump for gas microspheres or contrast agents of any one of claims 7 to 8;
Optionally, the ultrasound contrast is a cardiac ultrasound enhanced visualization, a uterotubal ultrasound enhanced visualization or a thyro-ultrasound enhanced visualization;
Optionally, the ultrasound imaging method comprises diluting the gas microsphere or the contrast agent, injecting the gas microsphere or the contrast agent by using the control method of any one of claims 1 to 5, the micropump control system of claim 6 or the gas microsphere or the contrast agent of any one of claims 7 to 8, and performing ultrasound imaging;
Optionally, the ultrasound imaging method comprises performing ultrasound imaging after diluting the gas microsphere or the contrast agent to 15mL to 30mL, using the control method according to any one of claims 1 to 5, the micropump control system according to claim 6, or the gas microsphere or the contrast agent according to any one of claims 7 to 8.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202410109165.6A CN117899291A (en) | 2024-01-25 | 2024-01-25 | Control method, control system and application of micro pump for gas microsphere or contrast agent |
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| CN202410109165.6A CN117899291A (en) | 2024-01-25 | 2024-01-25 | Control method, control system and application of micro pump for gas microsphere or contrast agent |
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| CN202410109165.6A Pending CN117899291A (en) | 2024-01-25 | 2024-01-25 | Control method, control system and application of micro pump for gas microsphere or contrast agent |
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| CN (1) | CN117899291A (en) |
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