CN117771296A - Composition for preventing allergic rhinitis - Google Patents
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Abstract
The invention relates to the technical field of traditional Chinese medicines, and discloses a composition for preventing allergic rhinitis, which is prepared by extracting pure natural herbal medicines such as astragalus, angelica dahurica, fructus xanthil, magnolia flower, asarum, peppermint, centipeda minima and the like, can obviously exert a synergistic effect under a certain dosage proportion, has a good treatment effect on allergic rhinitis, does not need to add any chemical agent for the second time, can be directly applied to corresponding acupuncture points, does not need to be taken, does not pass through viscera and channels, is safe, healthy and has no toxic or side effect; the patch uses sodium polyacrylate as matrix, sodium carboxymethylcellulose as adhesive, glycerol and polyethylene glycol as humectant, aluminum glycollate as crosslinking agent, and water thorn cloth as matrix material, and uses the prepared traditional Chinese medicine for dispelling pathogenic wind, dispelling cold, inducing resuscitation and relieving pain, and can be applied on acupoints such as Yingxiang acupoint on nose to treat internal diseases, and relieve pain.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a composition for preventing allergic rhinitis.
Background
Allergic rhinitis is a chronic nasal mucosa inflammation mainly characterized by itching, sneezing and nasal discharge, can continuously induce asthma, conjunctivitis, chronic nasosinusitis and other diseases to occur simultaneously for a long time, has serious influence on the physical health of people and has adverse effects on work and study, most of common medicines are western medicines such as antihistamines, glucocorticoids, leukotriene resisting medicines and the like, but the medicines have certain toxic and side effects on human bodies, still cannot be thoroughly treated, and easily generate drug resistance after repeated use and the like; in contrast, the traditional Chinese medicine can treat the allergic rhinitis based on syndrome differentiation, has no side effect or little side effect, has better curative effect in recent years by applying the traditional Chinese medicine to treat the allergic rhinitis, and becomes a research hot spot.
At present, more traditional Chinese medicine decoction is used for treatment, and according to the syndrome differentiation and treatment of the whole body symptoms of patients, five internal organs can be regulated internally and pathogenic factors can be removed externally, but because the traditional Chinese medicine is bitter in taste and troublesome to decoct, many patients cannot keep taking medicines or give up taking at first time, and the aim of good treatment cannot be achieved; in addition, due to the specificity that allergic rhinitis is difficult to radically cure, the protective articles which are simple and easy to use are developed, and the protective articles have certain advantages in the aspects of preventing and relieving symptoms of the allergic rhinitis. The invention extracts the components in the Chinese herbal medicines, simultaneously makes the Chinese herbal medicine components put on the spunlaced cloth, acts on the Yingxiang acupoint of the nose, can be absorbed through the nasal mucosa, can prevent and treat allergic rhinitis, has simple operation and is easy to carry.
Disclosure of Invention
(one) solving the technical problems
Aiming at the defects of the prior art, the invention provides a composition for preventing allergic rhinitis, which has the advantages of relieving symptoms of allergic rhinitis and being convenient to use.
(II) technical scheme
In order to achieve the above purpose, the present invention provides the following technical solutions: a composition for preventing allergic rhinitis, which is prepared by the following steps:
(1) Preparing filter residues of centipeda minima and an aqueous extract of centipeda minima: weighing herba Centipedae, pulverizing, sieving, drying, soaking in distilled water for 20-40min, reflux extracting by water extraction, centrifuging, and filtering to obtain herba Centipedae residue and herba Centipedae water extract.
(2) Preparing a centipeda minima extract: mashing 100 parts of centipeda minima filter residues in the step (1), drying at 50-70 ℃ for 8-16h, placing into a high-pressure reaction kettle, adding 800-1500mL of entrainer ethanol solution, and performing supercritical CO 2 Extracting, regulating pH of the extract to 6-8, concentrating under reduced pressure, and drying to obtain herba Centipedae extract.
(3) Preparing a centipeda minima extract: uniformly mixing the water extract of the centipeda minima, which is obtained in the step (1), and the extract of the centipeda minima, which is obtained in the step (2), and drying in vacuum to remove the solvent, thereby obtaining the extract of the centipeda minima.
(4) Cutting folium Menthae into fine particles, sieving with 50-100 mesh sieve, adding into distilled water and ethanol solvent, stirring, extracting in 200-400W ultrasonic device, centrifuging, collecting supernatant, and distilling under reduced pressure to remove ethanol to obtain herba Menthae extractive solution.
(5) Preparing a traditional Chinese medicine mixed extract: ball milling radix astragali, radix Angelicae Dahuricae, fructus Xanthii, flos Magnoliae and herba asari by ball mill until passing 300-500 mesh sieve, dispersing the mixed powder in ethanol solvent, extracting by ethanol extraction method, centrifuging at 3000-4000r/min for 10-30min, distilling supernatant under reduced pressure, and vacuum drying to obtain mixed Chinese medicinal extract.
(6) Adding glycerol and polyethylene glycol into distilled water, stirring for swelling, adding sodium polyacrylate, aluminum glycollate, citric acid and sodium carboxymethylcellulose, dispersing uniformly, adding herba Centipedae extract, herba Menthae extract and mixed Chinese medicinal extract, stirring thoroughly at 40-60deg.C for 15-30min, spreading on water thorn cloth while it is hot, aging at 35-45deg.C for 1-2 hr, and drying at room temperature to obtain composition for preventing allergic rhinitis.
Further, in the step (1), the weight portion of the centipeda minima is 5-12, and the weight portion of the distilled water is 100.
Further, the water extraction temperature in the step (1) is 95-115 ℃ and the reflux time is 1-3h.
Further, the supercritical CO in the step (2) 2 The extraction temperature is 40-50deg.C, the extraction pressure is 30-40MPa, the extraction time is 40-60min, and CO 2 The flow rate of (2) is 30-60g/min.
Further, in the step (4), the mass portion of the mint leaves is 4-8, the portion of the distilled water is 100, and the portion of the ethanol is 20-40.
Further, in the step (4), the ultrasonic temperature is 30-50 ℃ and the ultrasonic time is 5-25min.
Further, in the step (5), the parts by weight of astragalus, angelica dahurica, fructus xanthil, magnolia flower, asarum and ethanol are 35-45 parts, 10-15 parts, 5-12 parts, 15-20 parts, 2-5 parts and 1200-2000 parts respectively.
Further, the extraction temperature in the step (5) is 75-90 ℃, and the reflux time is 4-8h.
Further, in the step (6), the mass parts of glycerin, polyethylene glycol, distilled water, sodium polyacrylate, aluminum glycollate, citric acid, sodium carboxymethylcellulose, centipeda minima extract, peppermint extract and mixed traditional Chinese medicine extract are respectively 20-30 parts, 0.5-1.5 parts, 30-60 parts, 0.8-1.2 parts, 0.4-0.6 parts, 0.1-0.3 parts, 0.5-1.0 parts, 0.2-0.8 parts, 0.05-0.2 parts and 0.5-1.5 parts.
(III) beneficial technical effects
Compared with the prior art, the invention has the following beneficial technical effects:
the invention firstly adopts a water extraction method and supercritical CO 2 Extracting effective components of herba Centipedae to obtain herba Centipedae extract, ultrasonically extracting folium Menthae to obtain herba Menthae extract, and extracting radix astragali and radix Angelicae DahuricaeExtracting fructus Xanthii, flos Magnoliae and herba asari with alcohol to obtain mixed Chinese medicinal extract, mixing with sodium polyacrylate as matrix, sodium carboxymethylcellulose as binder, glycerol and polyethylene glycol as humectant, aluminum glycollate as crosslinking agent, and water thorn cloth as matrix material, and aging to obtain the composition for preventing allergic rhinitis.
The astragalus has sweet taste and mild nature, has the nourishing effect of tonifying qi and strengthening the surface, is beneficial to the outward discharge of toxin in the body and has curative effect on rhinitis; flos Magnoliae has effects of dispelling pathogenic wind, inducing resuscitation, treating headache, nasosinusitis, nasal obstruction, and relieving inflammation; herba asari has effects of dispelling pathogenic wind and cold, inducing resuscitation and relieving pain, warming lung and resolving fluid retention, and can also be used for sterilizing; radix Angelicae Dahuricae has effects of dispelling pathogenic wind, relieving exterior syndrome, dispelling cold, eliminating dampness, and can be used for treating common cold due to wind-cold, headache, cough, nasosinusitis, and pyocutaneous disease; fructus Xanthii can dispel wind and remove dampness, unblock orifices and relieve pain, dispel wind and relieve itching, and effectively relieve symptoms of nasosinusitis headache; centipeda minima has the effects of dispersing wind-cold, relieving stuffy nose, relieving cough and detoxifying; peppermint is fresh and refreshing, and can dispel wind and dissipate heat, and is easy to relieve stuffy nose. The components have synergistic effect, have the effects of dispelling wind-cold and relieving stuffy nose, can treat other inflammation symptoms, and comprehensively regulate and relieve drug properties.
The Chinese herbal medicine components are prepared into the application, act on acupoints such as Yingxiang acupoint of nose, can be absorbed through nasal mucosa, can prevent and treat allergic rhinitis, directly improve nose symptoms, does not need to be taken, does not pass through viscera and channels and collaterals, is quick to treat, is easy to operate, has no pain and is easy to carry, and can be accepted by patients; the application agent takes sodium polyacrylate as a matrix, sodium carboxymethylcellulose as an adhesive, glycerin and polyethylene glycol as a humectant, aluminum glycollate as a crosslinking agent and water thorn cloth as a matrix material, and the prepared traditional Chinese medicine has the characteristics of dispelling wind and cold, inducing resuscitation and relieving pain, and is applied on corresponding acupuncture points to achieve the effects of treating internal diseases externally and eliminating pathogenic factors and dispelling cold; the application is soft and comfortable, has lasting effect and no irritation to skin.
Detailed Description
The following description will clearly and fully describe the technical solutions of the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments.
Example 1
(1) Preparing filter residues of centipeda minima and an aqueous extract of centipeda minima: weighing 24g of centipeda minima, crushing, sieving, drying, adding 300g of distilled water, soaking for 35min, extracting at 105 ℃ for 2h by a water extraction method, centrifuging, and filtering to obtain centipeda minima filter residues and centipeda minima water extract.
(2) Preparing a centipeda minima extract: mashing 15g of centipeda minima filter residues in the step (1), drying at 65 ℃ for 12 hours, placing into a high-pressure reaction kettle, adding 180mL of entrainer ethanol solution, and carrying out supercritical CO 2 Extraction, supercritical CO 2 The extraction temperature is 45 ℃, the extraction pressure is 30MPa, the extraction time is 50min, and CO 2 The flow rate of the extract is 50g/min, the pH of the extract is regulated to 7, and the extract is dried to obtain the centipeda minima extract after decompression and concentration.
(3) Preparing a centipeda minima extract: uniformly mixing the water extract of the centipeda minima, which is obtained in the step (1), and the extract of the centipeda minima, which is obtained in the step (2), and drying in vacuum to remove the solvent, thereby obtaining the extract of the centipeda minima.
(4) 3g of mint leaves are cut into fine particles, sieved by a 80-mesh sieve, added into 50g of distilled water and 35g of ethanol solvent, stirred uniformly, extracted in a device with ultrasonic power of 350W and ultrasonic temperature of 40 ℃ and ultrasonic time of 15min, centrifuged to collect supernatant, and ethanol is removed by reduced pressure distillation to obtain mint extract.
(5) Preparing a traditional Chinese medicine mixed extract: ball milling 42g of astragalus, 13g of angelica dahurica, 8g of fructus xanthil, 17g of magnolia flower and 3g of asarum through a ball mill until the mixed powder passes through a 350-mesh sieve, uniformly dispersing the mixed powder into 850mL of ethanol solvent, carrying out reflux extraction for 5h through an alcohol extraction method at 80 ℃, carrying out centrifugal separation for 25min at the rotating speed of 3500r/min, carrying out reduced pressure distillation on the supernatant, and carrying out vacuum drying to obtain the mixed traditional Chinese medicine extract.
(6) Adding 25g of glycerol and 0.8g of polyethylene glycol into 55g of distilled water, stirring and swelling, adding 0.9g of sodium polyacrylate, 0.6g of sodium glycollate, 0.15g of citric acid and 0.7g of sodium carboxymethyl cellulose, uniformly dispersing, adding 0.2g of centipeda minima extract, 0.05g of peppermint extract and 0.5g of mixed traditional Chinese medicine extract, fully stirring at 55 ℃ for 25min, spreading on a spunlaced fabric while the mixture is hot, curing for 2h at 40 ℃, drying and forming at room temperature, and obtaining the composition for preventing allergic rhinitis.
Example 2
(1) Preparing filter residues of centipeda minima and an aqueous extract of centipeda minima: weighing 60g of centipeda minima, crushing, sieving, drying, adding 500g of distilled water, soaking for 40min, extracting at 110 ℃ for 3h by refluxing through a water extraction method, centrifuging, and filtering to obtain centipeda minima filter residues and centipeda minima water extract.
(2) Preparing a centipeda minima extract: mashing 50g of centipeda minima filter residues in the step (1), drying at 55 ℃ for 16h, placing into a high-pressure reaction kettle, adding 700mL of entrainer ethanol solution, and carrying out supercritical CO 2 Extraction, supercritical CO 2 The extraction temperature is 50deg.C, the extraction pressure is 40MPa, the extraction time is 50min, and CO 2 The flow rate of the extract is 60g/min, the pH of the extract is regulated to 8, and the extract is dried to obtain the centipeda minima extract after decompression and concentration.
(3) Preparing a centipeda minima extract: uniformly mixing the water extract of the centipeda minima, which is obtained in the step (1), and the extract of the centipeda minima, which is obtained in the step (2), and drying in vacuum to remove the solvent, thereby obtaining the extract of the centipeda minima.
(4) Cutting 6g of mint leaves into fine particles, sieving with a 60-mesh sieve, adding into 80g of distilled water and 35g of ethanol solvent, stirring uniformly, extracting in a device with ultrasonic power of 250W and ultrasonic temperature of 45 ℃ for 10min, centrifuging, collecting supernatant, and distilling under reduced pressure to remove ethanol to obtain mint extract.
(5) Preparing a traditional Chinese medicine mixed extract: ball milling 35g of astragalus, 15g of angelica dahurica, 9g of fructus xanthil, 18g of magnolia flower and 4g of asarum through a ball mill until the mixture passes through a 450-mesh sieve, uniformly dispersing the mixed powder into 1200mL of ethanol solvent, carrying out reflux extraction for 8h through an ethanol extraction method at 85 ℃, carrying out centrifugal separation for 150min at the rotating speed of 4000r/min, carrying out reduced pressure distillation on the supernatant, and carrying out vacuum drying to obtain the mixed traditional Chinese medicine extract.
(6) Adding 30g of glycerol and 0.9g of polyethylene glycol into 50g of distilled water, stirring and swelling, adding 1.1g of sodium polyacrylate, 0.5g of sodium glycollate, 0.25g of citric acid and 0.8g of sodium carboxymethyl cellulose, uniformly dispersing, adding 0.4g of centipeda minima extract, 0.1g of peppermint extract and 0.8g of mixed traditional Chinese medicine extract, fully stirring at 50 ℃ for 20min, spreading on a spunlaced fabric while the mixture is hot, curing for 1h at 40 ℃, drying and forming at room temperature, and obtaining the composition for preventing allergic rhinitis.
Example 3
(1) Preparing filter residues of centipeda minima and an aqueous extract of centipeda minima: 27g of centipeda minima is weighed, crushed, sieved and dried, 300g of distilled water is added for soaking for 20min, reflux extraction is carried out for 3h by a water extraction method at 95 ℃, centrifugal separation is carried out, and filter residues of the centipeda minima and an extraction liquid of the centipeda minima are obtained by filtering.
(2) Preparing a centipeda minima extract: mashing 20g of centipeda minima filter residues in the step (1), drying at 70 ℃ for 8 hours, placing into a high-pressure reaction kettle, adding 240mL of entrainer ethanol solution, and carrying out supercritical CO 2 Extraction, supercritical CO 2 The extraction temperature is 50deg.C, the extraction pressure is 30MPa, the extraction time is 55min, and CO 2 The flow rate of the extract is 60g/min, the pH of the extract is regulated to 6, and the extract is dried to obtain the centipeda minima extract after decompression and concentration.
(3) Preparing a centipeda minima extract: uniformly mixing the water extract of the centipeda minima, which is obtained in the step (1), and the extract of the centipeda minima, which is obtained in the step (2), and drying in vacuum to remove the solvent, thereby obtaining the extract of the centipeda minima.
(4) Cutting 8g of mint leaves into fine particles, sieving with a 90-mesh sieve, adding into 100g of distilled water and 30g of ethanol solvent, stirring uniformly, extracting in a device with ultrasonic power of 330W and ultrasonic temperature of 35 ℃ and ultrasonic time of 25min, centrifuging, collecting supernatant, and distilling under reduced pressure to remove ethanol to obtain mint extract.
(5) Preparing a traditional Chinese medicine mixed extract: ball milling 45g of astragalus, 10g of angelica dahurica, 12g of fructus xanthil, 16g of magnolia flower and 3g of asarum through a ball mill until the mixture passes through a 400-mesh sieve, uniformly dispersing the mixed powder into 1000mL of ethanol solvent, carrying out reflux extraction for 5h through an ethanol extraction method at 90 ℃, carrying out centrifugal separation for 30min at a rotating speed of 3000r/min, carrying out reduced pressure distillation on the supernatant, and carrying out vacuum drying to obtain the mixed traditional Chinese medicine extract.
(6) Adding 20g of glycerol and 1.2g of polyethylene glycol into 45g of distilled water, stirring and swelling, adding 1.2g of sodium polyacrylate, 0.4g of sodium glycollate, 0.25g of citric acid and 0.8g of sodium carboxymethyl cellulose, uniformly dispersing, adding 0.6g of centipeda minima extract, 0.15g of peppermint extract and 1.2g of mixed traditional Chinese medicine extract, fully stirring at 60 ℃ for 25min, spreading on a spunlaced fabric while the mixture is hot, curing for 2h at 45 ℃, drying and forming at room temperature, and obtaining the composition for preventing allergic rhinitis.
Example 4
(1) Preparing filter residues of centipeda minima and an aqueous extract of centipeda minima: weighing 12g of centipeda minima, crushing, sieving, drying, adding 130g of distilled water, soaking for 40min, extracting by a water extraction method at 100 ℃ under reflux for 2h, centrifuging, and filtering to obtain centipeda minima filter residues and centipeda minima water extract.
(2) Preparing a centipeda minima extract: mashing 5g of centipeda minima filter residues in the step (1), drying at 70 ℃ for 10h, placing into a high-pressure reaction kettle, adding 60mL of entrainer ethanol solution, and performing supercritical CO 2 Extraction, supercritical CO 2 The extraction temperature is 50 ℃, the extraction pressure is 36MPa, the extraction time is 45min, and CO 2 The flow rate of the extract is 50g/min, the pH of the extract is regulated to 7, and the extract is dried to obtain the centipeda minima extract after decompression and concentration.
(3) Preparing a centipeda minima extract: uniformly mixing the water extract of the centipeda minima, which is obtained in the step (1), and the extract of the centipeda minima, which is obtained in the step (2), and drying in vacuum to remove the solvent, thereby obtaining the extract of the centipeda minima.
(4) Cutting 12g of mint leaves into fine particles, sieving with a 50-mesh sieve, adding into 250g of distilled water and 75g of ethanol solvent, stirring uniformly, extracting in a device with ultrasonic power of 400W and ultrasonic temperature of 50 ℃ and ultrasonic time of 20min, centrifuging, collecting supernatant, and distilling under reduced pressure to remove ethanol to obtain mint extract.
(5) Preparing a traditional Chinese medicine mixed extract: ball milling 36g of astragalus, 14g of angelica dahurica, 22g of fructus xanthil, 19g of magnolia flower and 5g of asarum through a ball mill until the mixture passes through a 500-mesh sieve, uniformly dispersing the mixed powder in 1300mL of ethanol solvent, carrying out reflux extraction for 8h through an ethanol extraction method at 80 ℃, carrying out centrifugal separation for 30min at the rotating speed of 3800r/min, carrying out reduced pressure distillation on the supernatant, and carrying out vacuum drying to obtain the mixed traditional Chinese medicine extract.
(6) Adding 28g of glycerol and 1.5g of polyethylene glycol into 55g of distilled water, stirring and swelling, adding 0.9g of sodium polyacrylate, 0.5g of sodium glycollate, 0.25g of citric acid and 0.9g of sodium carboxymethyl cellulose, uniformly dispersing, adding 0.8g of centipeda minima extract, 0.2g of peppermint extract and 1.5g of mixed traditional Chinese medicine extract, fully stirring at 55 ℃ for 25min, spreading on spunlaced cloth while the mixture is hot, curing for 2h at 40 ℃, drying and forming at room temperature, and obtaining the composition for preventing allergic rhinitis.
Comparative example 1
(1) Preparing filter residues of centipeda minima and an aqueous extract of centipeda minima: weighing 8g of centipeda minima, crushing, sieving, drying, adding 100g of distilled water, soaking for 40min, extracting at 115 ℃ for 1.5h by a water extraction method, centrifuging, and filtering to obtain centipeda minima filter residues and centipeda minima water extract.
(2) Preparing a centipeda minima extract: mashing 3g of centipeda minima filter residues in the step (1), drying at 70 ℃ for 16h, placing into a high-pressure reaction kettle, adding 40mL of entrainer ethanol solution, and performing supercritical CO 2 Extraction, supercritical CO 2 The extraction temperature is 50 ℃, the extraction pressure is 35MPa, the extraction time is 45min, and CO 2 The flow rate of the extract is 50g/min, the pH of the extract is regulated to 7, and the extract is dried to obtain the centipeda minima extract after decompression and concentration.
(3) Preparing a centipeda minima extract: uniformly mixing the water extract of the centipeda minima, which is obtained in the step (1), and the extract of the centipeda minima, which is obtained in the step (2), and drying in vacuum to remove the solvent, thereby obtaining the extract of the centipeda minima.
(4) Adding 30g of glycerol and 1.5g of polyethylene glycol into 40g of distilled water, stirring and swelling, adding 1.2g of sodium polyacrylate, 0.4g of sodium glycollate, 0.3g of citric acid and 0.8g of sodium carboxymethyl cellulose, uniformly dispersing, adding 0.2g of Centipeda minima extract, fully stirring at 50 ℃ for 20min, spreading on a spunlaced fabric while the mixture is hot, curing at 35 ℃ for 2h, and drying and molding at room temperature to obtain the composition for preventing rhinitis.
Comparative example 2
(1) Cutting 7g of mint leaves into fine particles, sieving with a 70-mesh sieve, adding into 100g of distilled water and 35g of ethanol solvent, stirring uniformly, extracting in a device with ultrasonic power of 400W and ultrasonic temperature of 45 ℃ for 20min, centrifuging, collecting supernatant, and distilling under reduced pressure to remove ethanol to obtain mint extract.
(2) Adding 25g of glycerol and 1.5g of polyethylene glycol into 55g of distilled water, stirring and swelling, adding 0.8g of sodium polyacrylate, 0.6g of aluminum glycollate, 0.2g of citric acid and 1.0g of sodium carboxymethyl cellulose, uniformly dispersing, adding 0.05g of peppermint extract, fully stirring at 50 ℃ for 30min, spreading on a spunlaced fabric while the mixture is hot, curing at 45 ℃ for 1h, and drying and molding at room temperature to obtain the composition for preventing rhinitis.
Comparative example 3
(1) Preparing a traditional Chinese medicine mixed extract: 45g of astragalus, 10g of angelica dahurica, 9g of cocklebur fruit, 20g of magnolia flower and 3g of asarum are ball-milled by a ball mill until passing through a 450-mesh sieve, the mixed powder is uniformly dispersed in 1300mL of ethanol solvent, reflux extraction is carried out for 8h by an alcohol extraction method at 85 ℃, centrifugal separation is carried out for 30min at the rotating speed of 4000r/min, and the supernatant is distilled under reduced pressure and dried in vacuum, thus obtaining the mixed traditional Chinese medicine extract.
(6) Adding 30g of glycerol and 0.6g of polyethylene glycol into 60g of distilled water, stirring and swelling, adding 0.9g of sodium polyacrylate, 0.6g of sodium glycollate, 0.25g of citric acid and 0.9g of sodium carboxymethyl cellulose, uniformly dispersing, adding 0.5g of mixed traditional Chinese medicine extract, fully stirring at 60 ℃ for 20min, spreading on a spunlaced fabric while the mixture is hot, curing at 40 ℃ for 2h, drying and molding at room temperature, and obtaining the composition for preventing rhinitis.
Case selection: 280 rhinitis patients are selected, wherein 140 men and women are aged 35 years on average and the average course of disease is 2-3 years, 7 groups of patients are randomly divided into examples 1-4 and comparative examples 1-3, 40 groups of patients have no significant difference in age, disease weight, disease course comparison and other data, and the patients have comparability.
Treatment protocol: the compositions obtained in examples 1-4 and comparative examples 1-3 were used for treating 7 cases, the prepared water-jet cloth containing 0.05g of Chinese herbal medicine was cut into a shape of 2cm×2cm, and applied to the Yingxiang acupoint of nose for 1 time each day, each time for 30min, and the treatment effect was checked after 2 months.
Standard of efficacy:
and (3) the effect standard: the symptoms of nasal itching, nasal obstruction, sneeze, clear nasal discharge, hyposmia and the like basically disappear.
The effective standard is as follows: the symptoms such as nasal itching, nasal obstruction, sneeze and the like are improved.
The effective standard is as follows: the symptoms such as nasal itching, nasal obstruction, sneeze and the like are persistent and not improved.
As can be seen from the table, the rhinitis preventing composition prepared by the invention has good treatment effect on allergic rhinitis, and as the content of the centipeda minima, the mint and the mixed traditional Chinese medicine extracts in the composition is increased, more than 90% of patients' symptoms are relieved, 39 patients in the example 4 are basically healed, and the total effective rate reaches 100%, because the composition adopts the pure natural herbal traditional Chinese medicines such as astragalus, angelica dahurica, fructus xanthil, magnolia flower, asarum, mint, centipeda minima and the like, has the effects of dispelling wind and cold, inducing resuscitation and relieving pain, and has the effects of refreshing mint and refreshing mind, dispelling wind and cooling, and is easy to induce nose, and the composition is directly applied to a nose and fragrance-welcoming acupoint for removal without taking, does not pass viscera and channels and collaterals, is safe, healthy and has no toxic or side effect, and has better treatment effect.
In comparative example 1, only the centipeda minima extract is added, and the total effective rate is 67.5%; in comparative example 2, only peppermint extract was added, the total effective rate was 45.0%, and in comparative example 3, only mixed Chinese medicinal extract was added, the total effective rate was 82.5%; therefore, the therapeutic effect of the composition of the example 1 on the allergic rhinitis is obviously better than that of the comparison groups 1-3 under the same dosage, which shows that the pharmaceutical composition of the invention can exert a synergistic effect and has obvious efficacy under a certain proportion.
It is worth noting that the rhinitis composition provided by the invention has the advantages of short coating time, small dosage, about one week of days for achieving symptom relief in the actual use process, capability of allowing traditional Chinese medicine components to permeate into veins through skin to exert medicine effect, small irritation, good patient compliance, more convenience than the traditional application, quick response and high cure rate.
The foregoing has shown and described the basic principles and main features of the present invention and the advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
1. The preparation method of the composition for preventing allergic rhinitis is as follows:
(1) Preparing filter residues of centipeda minima and an aqueous extract of centipeda minima: weighing herba Centipedae, pulverizing, sieving, drying, soaking in distilled water for 20-40min, reflux extracting by water extraction, centrifuging, and filtering to obtain herba Centipedae residue and herba Centipedae water extract;
(2) Preparing a centipeda minima extract: mashing 100 parts of centipeda minima filter residues in the step (1), drying at 50-70 ℃ for 8-16h, placing into a high-pressure reaction kettle, adding 800-1500mL of entrainer ethanol solution, and performing supercritical CO 2 Extracting, regulating pH of the extract to 6-8, concentrating under reduced pressure, and drying to obtain herba Centipedae extract;
(3) Preparing a centipeda minima extract: uniformly mixing the water extract of the centipeda minima, which is obtained in the step (1), and the extract of the centipeda minima, which is obtained in the step (2), and drying in vacuum to remove the solvent, thereby obtaining the extract of the centipeda minima;
(4) Cutting peppermint leaf into fine particles, sieving with a 50-100 mesh sieve, adding into distilled water and ethanol solvent, stirring uniformly, extracting in a device with ultrasonic power of 200-400W, centrifuging, collecting supernatant, and distilling under reduced pressure to remove ethanol to obtain peppermint extract;
(5) Preparing a traditional Chinese medicine mixed extract: ball milling radix astragali, radix Angelicae Dahuricae, fructus Xanthii, flos Magnoliae and herba asari by ball mill until passing 300-500 mesh sieve, dispersing the mixed powder in ethanol solvent, extracting by alcohol extraction method, centrifuging at 3000-4000r/min for 10-30min, distilling supernatant under reduced pressure, and vacuum drying to obtain mixed Chinese medicinal extract;
(6) Adding glycerol and polyethylene glycol into distilled water, stirring for swelling, adding sodium polyacrylate, aluminum glycollate, citric acid and sodium carboxymethylcellulose, dispersing uniformly, adding herba Centipedae extract, herba Menthae extract and mixed Chinese medicinal extract, stirring thoroughly at 40-60deg.C for 15-30min, spreading on water thorn cloth while it is hot, aging at 35-45deg.C for 1-2 hr, and drying at room temperature to obtain composition for preventing allergic rhinitis.
2. The composition for preventing allergic rhinitis according to claim 1, wherein the weight portion of the centipeda minima in the step (1) is 5-12, and the weight portion of the distilled water is 100.
3. The composition for preventing allergic rhinitis according to claim 1, wherein the water extraction temperature in step (1) is 95 to 115 ℃ and the reflux time is 1 to 3 hours.
4. The allergic rhinitis preventing composition according to claim 1, wherein supercritical CO in step (2) 2 The extraction temperature is 40-50deg.C, the extraction pressure is 30-40MPa, the extraction time is 40-60min, and CO 2 The flow rate of (2) is 30-60g/min.
5. The allergic rhinitis preventing composition according to claim 1, wherein in the step (4), the mass fraction of peppermint leaf is 4-8, the fraction of distilled water is 100, and the fraction of ethanol is 20-40.
6. The composition for preventing allergic rhinitis according to claim 1, wherein the ultrasound temperature in step (4) is 30 to 50 ℃ and the ultrasound time is 5 to 25min.
7. The composition for preventing allergic rhinitis according to claim 1, wherein in the step (5), the parts by mass of astragalus, dahurian angelica root, cocklebur fruit, magnolia flower, asarum and ethanol are 35-45 parts, 10-15 parts, 5-12 parts, 15-20 parts, 2-5 parts and 1200-2000 parts, respectively.
8. The composition for preventing allergic rhinitis according to claim 1, wherein the extraction temperature in step (5) is 75 to 90 ℃ and the reflux time is 4 to 8 hours.
9. The composition for preventing allergic rhinitis according to claim 1, wherein in the step (6), the parts by mass of glycerin, polyethylene glycol, distilled water, sodium polyacrylate, aluminum glycollate, citric acid, sodium carboxymethyl cellulose, centipeda minima extract, peppermint extract and mixed Chinese medicinal extract are respectively 20-30 parts, 0.5-1.5 parts, 30-60 parts, 0.8-1.2 parts, 0.4-0.6 parts, 0.1-0.3 parts g, 0.5-1.0 parts, 0.2-0.8 parts, 0.05-0.2 parts and 0.5-1.5 parts.
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