CN117717704B - Pump blood flow estimation system and method based on ventricular catheter pump - Google Patents

Abstract

The embodiment of the application provides a pump blood flow estimation system and method based on a ventricular catheter pump, which relate to the technical field of medical equipment, wherein the control controller comprises an information acquisition module, an interference determination module, a differential pressure adjustment module and a flow determination module, wherein: the information acquisition module is used for acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in the current cardiac cycle; the interference determination module is used for determining association characteristics representing association characteristics between the left ventricle pressure and the aortic pressure, and determining target interference characteristics representing interference characteristics of interference suffered by the optical fiber pressure sensor based on the association characteristics; the differential pressure adjusting module is used for determining a differential pressure deviation value based on the target interference characteristic and adjusting the differential pressure based on the differential pressure value; the flow determination module is used for determining the pump blood flow of the ventricular catheter pump based on the adjusted pressure difference. By applying the scheme provided by the embodiment, the accurate estimation of the pump blood flow can be realized.

Description

Pump blood flow estimation system and method based on ventricular catheter pump

Technical Field

The application relates to the technical field of medical equipment, in particular to a pump blood flow estimation system and method based on a ventricular catheter pump.

Background

Ventricular catheter pumps are devices that provide support or assist functions for patients suffering from heart related diseases, such as heart failure, to assist the heart in pumping blood to other parts of the body.

When the ventricular catheter pump is operated, the pump blood flow of the ventricular catheter pump needs to be accurately detected, and the pump blood flow of the ventricular catheter pump is used for measuring the contribution of auxiliary pump blood of the ventricular catheter pump. Based on the pump blood flow, the current operation of the ventricular catheter pump can be determined, thereby better controlling the operation of the ventricular catheter pump.

Disclosure of Invention

The embodiment of the application aims to provide a pump blood flow estimation system and method based on a ventricular catheter pump, so as to realize accurate detection of the pump blood flow. The specific technical scheme is as follows:

In a first aspect, embodiments of the present application provide a pump blood flow estimation system based on a ventricular catheter pump, the system comprising: a ventricular catheter pump, a controller, a pressure sensor, the ventricular catheter pump comprising: the device comprises a driving assembly, a pumping assembly, a blood inlet cage, a blood outlet cage and an optical fiber pressure sensor; wherein:

When the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient;

The pressure sensor is arranged outside the patient and is used for detecting the aortic pressure of the patient;

the controller comprises an information acquisition module, an interference determination module, a differential pressure adjustment module and a flow determination module, wherein:

The information acquisition module is used for acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in the current cardiac cycle;

a disturbance determining module for determining a correlation characteristic characterizing a correlation characteristic between left ventricular pressure and aortic pressure, and determining a target disturbance characteristic characterizing a disturbance characteristic to which the optical fiber pressure sensor is disturbed based on the correlation characteristic;

a differential pressure adjustment module for calculating a differential pressure between the aortic pressure and the left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

and the flow determining module is used for determining the pump blood flow of the ventricular catheter pump based on the adjusted pressure difference.

In one embodiment of the present application, the flow determining module is specifically configured to obtain a first state parameter indicating a vascular resistance state and a second state parameter indicating a vascular inertia state; calculating a pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted pressure differential.

In one embodiment of the present application, the flow determination module is specifically configured to calculate a pump blood flow of the ventricular catheter pump according to the following expression:

；

Wherein, Representing the flow of pump blood,/>Representing differential pressure,/>For the preset coefficient,/>Representing the first state parameter,/>Representing a second state parameter.

In one embodiment of the present application, the interference determining module includes:

The first characteristic determining submodule is used for determining the association characteristic representing the association characteristic between the left ventricular pressure and the aortic pressure, determining target phases representing different movement conditions of the heart contained in the current cardiac cycle, and determining the target characteristic representing the phase characteristic of each target phase based on the corresponding relation between the pre-constructed heart movement phases and the movement phase characteristic;

a second feature determining sub-module, configured to calculate, for each target stage, a degree of matching between target features corresponding to the target stage, from among features included in the associated feature, and determine, based on the calculated degree of matching, a feature for the target stage, from among the associated features, as a first feature;

And the interference determination submodule is used for determining a fluctuation characteristic of the first characteristic corresponding to each target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the optical fiber pressure sensor in each target stage.

In an embodiment of the present application, the above-mentioned interference determining module further includes a third feature determining sub-module:

the third feature determining submodule is configured to calculate, for each target stage, a matching degree between a target feature corresponding to the target stage and a target feature corresponding to another target stage, and determine, as a second feature corresponding to the target stage, a first feature corresponding to the other target stage with the highest matching degree, before the interference determining submodule;

The interference determination submodule is specifically configured to, for each target stage, fuse a first feature and a second feature corresponding to the target stage to obtain a fused feature, determine a fluctuation feature of the fused feature corresponding to the target stage compared with a target feature corresponding to the target stage, and use the fluctuation feature as a target interference feature for representing interference characteristics of the optical fiber pressure sensor in each target stage.

In a second aspect, an embodiment of the present application provides a method for estimating a pump blood flow based on a ventricular catheter pump, which is applied to a controller in a pump blood flow estimating system, where the pump blood flow estimating system further includes a ventricular catheter pump and a pressure sensor; the optical fiber pressure sensor is integrated on the blood inlet cage side; a pressure sensor, disposed outside the patient, for detecting aortic pressure of the patient; the method comprises the following steps:

acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

Determining an associated feature characterizing an associated characteristic between left ventricular pressure and aortic pressure, determining a target interference feature characterizing an interference characteristic of interference suffered by the fiber optic pressure sensor based on the associated feature;

calculating a differential pressure between the aortic pressure and left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

Based on the adjusted differential pressure, a pump blood flow of the ventricular catheter pump is determined.

In one embodiment of the present application, determining the pump blood flow of the ventricular catheter pump based on the adjusted pressure difference includes:

Acquiring a first state parameter representing a vascular resistance state and a second state parameter representing a vascular inertia state;

calculating a pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted pressure differential.

In one embodiment of the present application, calculating the pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted pressure difference includes:

The pump blood flow of the ventricular catheter pump is calculated according to the following expression:

；

Wherein, Representing the flow of pump blood,/>Representing differential pressure,/>For the preset coefficient,/>Representing the first state parameter,/>Representing a second state parameter.

In one embodiment of the present application, determining the target interference characteristic characterizing the interference characteristic of the interference suffered by the optical fiber pressure sensor based on the correlation characteristic includes:

Determining target phases which are contained in the current cardiac cycle and represent different movement conditions of the heart, and determining target features representing phase characteristics of each target phase based on a corresponding relation between a pre-constructed heart movement phase and movement phase characteristic features;

For each target stage, calculating the matching degree between target features corresponding to the target stage in the features contained in the associated features, and determining the features for the target stage in the associated features as first features based on the calculated matching degree;

for each target stage, determining a fluctuation characteristic of a first characteristic corresponding to the target stage compared with a target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage.

In an embodiment of the present application, before determining, for each target stage, a fluctuation characteristic of the first characteristic corresponding to the target stage compared to the target characteristic corresponding to the target stage as the target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage, the method further includes:

For each target stage, calculating the matching degree between the target feature corresponding to the target stage and the target features corresponding to other target stages, and determining the first features corresponding to other target stages with the highest matching degree as the second features corresponding to the target stage;

For each target stage, determining the fluctuation characteristic of the first characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage comprises the following steps:

and aiming at each target stage, fusing the first characteristic and the second characteristic corresponding to the target stage to obtain a fused characteristic, and determining the fluctuation characteristic of the fused characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic for representing the interference characteristic of the optical fiber pressure sensor in each target stage.

In a third aspect, an embodiment of the present application provides a ventricular catheter pump, including a drive assembly, a pumping assembly, a blood inlet cage, a blood outlet cage, and an optical fiber pressure sensor; when the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient.

From the above, it can be seen that, by applying the system provided by the embodiment of the present application, the controller included in the system determines the interference characteristics of the interference suffered by the optical fiber pressure sensor by using the correlation characteristics of the correlation characteristics between the left ventricle pressure and the aortic pressure, determines the deviation value of the differential pressure based on the interference characteristics, and adjusts the differential pressure, thereby determining the pump blood flow based on the adjusted differential pressure. Because the correlation characteristic between the left ventricular pressure and the aortic pressure is related to the left ventricular pressure, the characteristic of the interference of the optical fiber pressure sensor can be accurately determined based on the correlation characteristic, so that the accuracy of the determined differential pressure is higher, the differential pressure is adjusted based on the differential pressure, the accuracy of the calculated differential pressure is improved, and the pump blood flow is determined based on the adjusted differential pressure, thereby realizing accurate detection of the pump blood flow of the ventricular catheter pump.

Of course, it is not necessary for any one product or method of practicing the application to achieve all of the advantages set forth above at the same time.

Drawings

In order to more clearly illustrate the embodiments of the application or the technical solutions in the prior art, the drawings used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the application, and other embodiments may be obtained according to these drawings to those skilled in the art.

Fig. 1 is a schematic diagram of a pump blood flow estimating system based on a ventricular catheter pump according to an embodiment of the present application;

FIG. 2 is a schematic diagram of a pump for ventricular catheters according to an embodiment of the application;

Fig. 3 is a schematic structural diagram of a first controller according to an embodiment of the present application;

fig. 4 is a schematic structural diagram of a second controller according to an embodiment of the present application;

Fig. 5 is a schematic structural diagram of a third controller according to an embodiment of the present application;

FIG. 6 is a flow chart of a first method for estimating pump blood flow based on a ventricular catheter pump according to an embodiment of the present application;

FIG. 7 is a flow chart of a second method for estimating pump blood flow based on a ventricular catheter pump according to an embodiment of the present application;

Fig. 8 is a flowchart of a third pump blood flow estimating method based on a ventricular catheter pump according to an embodiment of the present application.

Detailed Description

The following description of the embodiments of the present application will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present application, but not all embodiments. Based on the embodiments of the present application, all other embodiments obtained by the person skilled in the art based on the present application are included in the scope of protection of the present application.

The application provides a pump blood flow estimation system based on a ventricular catheter pump, which is shown in fig. 1, and comprises a ventricular catheter pump 101, a controller 102 and a pressure sensor 103, wherein the system structure shown in fig. 1 is a sketch.

Wherein the ventricular catheter pump 101 is used to assist the heart in pumping blood. The ventricular catheter pump 101 may be an axial flow pump, and the ventricular catheter pump 101 may be attached to the apex of the left ventricle, the right ventricle, or both ventricles of the heart.

The pressure sensor 103 is placed outside the patient's body for detecting the aortic pressure of the patient. The pressure sensor 103 may be an invasive pressure sensor or a non-invasive pressure sensor;

The controller 102 is connected to the ventricular catheter pump 101 and the pressure sensor 103. The controller 102 is used to detect parameter data of the ventricular catheter pump/patient and to control the operation of the ventricular catheter pump 101.

Fig. 2 shows a schematic diagram of a ventricular catheter pump, comprising a drive assembly 201, a pumping assembly 202, a blood inlet cage 203, a blood outlet cage 204, and an optical fiber pressure sensor 205, which are connected in sequence, and the structure of the ventricular catheter pump shown in fig. 2 is a schematic diagram.

After the ventricular catheter pump is implanted at a preset position of the heart, the blood inlet cage 203 is positioned in the left ventricle, the blood outlet cage 204 is positioned in the aorta, and the driving assembly 201 and the pumping assembly 202 are also positioned in the aorta.

When the ventricular catheter pump is implanted in the heart, the drive assembly 201 drives the pumping assembly 202 in rotation, such that blood is drawn from the blood inlet cage 203 and pumped up to the blood outlet cage 204, through the blood outlet cage 204 and into the aorta. Due to the function of the ventricular catheter pump, the auxiliary cardiac pumping is realized, and the left ventricular load is unloaded.

In the ventricular catheter pump provided by the present application, a fiber optic pressure sensor 205 is also integrated. The fiber optic pressure sensor 205 is integrated into the blood inlet cage 203 side of the ventricular catheter pump. After the ventricular catheter pump is implanted at a preset position of the heart, the blood inlet cage 203 is positioned in the left ventricle, and the optical fiber pressure sensor 205 detects the pressure of the left ventricle.

In the present application, the configuration shown in fig. 2, the drive assembly is positioned within the heart when the ventricular catheter pump is placed in the patient. In addition to this configuration, the drive assembly may be coupled to the pumping assembly via a flexible drive shaft such that the drive assembly may be located outside the patient when the ventricular catheter pump device is placed in the patient.

Fig. 3 shows a schematic diagram of a controller, and in the schematic diagram shown in fig. 3, the controller includes an information acquisition module 301, an interference determination module 302, a differential pressure adjustment module 303, and a flow determination module 304. The above modules are specifically described below.

The information acquisition module 301 is configured to acquire left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle.

The left ventricular pressure and the aortic pressure may be obtained by the controller from the two sensors in real time, or the two sensors may store pressure information of each detected cardiac cycle into a memory, and the controller may read the left ventricular pressure and the aortic pressure of the current cardiac cycle from the memory.

The disturbance determination module 302 is configured to determine a correlation characteristic that characterizes a correlation characteristic between the left ventricular pressure and the aortic pressure, and determine a target disturbance characteristic that characterizes a disturbance characteristic to which the fiber pressure sensor is subjected based on the correlation characteristic.

The above-mentioned correlation features are used to characterize the correlation between left ventricular pressure and aortic pressure. The correlation between the left ventricular pressure and the aortic pressure can be represented by various dimensional data, such as the correlation between the pressure change directions of the left ventricular pressure and the aortic pressure, the time sequence pressure difference between the left ventricular pressure and the aortic pressure, and the like.

In determining the correlation characteristic, in one embodiment, the pressure characteristics of the left ventricle pressure and the aortic pressure can be extracted respectively, and a preset characteristic correlation analysis algorithm is adopted to perform characteristic correlation analysis on the left ventricle pressure characteristic and the aortic pressure characteristic, so as to obtain the correlation characteristic.

The target disturbance characteristic is used to characterize the disturbance characteristics of the disturbance experienced by the fiber optic pressure sensor.

Fiber optic pressure sensors are susceptible to a variety of factors within the blood environment, such as pressure changes within the left ventricle, blood within the left ventricle, and the like. These factors can severely impact the accuracy of the fiber optic pressure sensor, resulting in greater ingress and egress of the measured left ventricular pressure from the fiber optic pressure sensor to the actual value.

The pressure sensor for measuring the aortic pressure is arranged outside the body, and the optical fiber pressure sensor is arranged in the body, so that the complexity of the environment in the body is far higher than that in the external environment. Therefore, the pressure sensor arranged outside the body is disturbed far less than the optical fiber sensor arranged in the left ventricle, and then the pressure value detected by the pressure sensor is close to the actual value, and the detection precision is far higher than that of the optical fiber sensor. This conclusion was also verified in a number of simulation test experiments and animal test experiments.

Because the correlation characteristic between the left ventricular pressure and the aortic pressure is related to the left ventricular pressure, the characteristic of the interference suffered by the optical fiber pressure sensor can be accurately determined based on the correlation characteristic.

When determining the target interference feature, in one embodiment, an interference prediction model may be trained in advance, and the relevant feature is input into the interference prediction model to obtain the interference feature output by the interference prediction model as the target interference feature. The interference prediction model can be obtained by training an initial neural network model by taking a sample correlation characteristic as a training sample and taking a sample interference characteristic representing interference characteristics of interference suffered by the sample optical fiber pressure sensor as a training reference, and is used for predicting the interference characteristics of the interference suffered by the optical fiber pressure sensor. The sample association features are as follows: the characteristic of the correlation between the left ventricular pressure detected by the optical fiber pressure sensor integrated with the sample ventricular catheter pump and the aortic pressure detected by the pressure sensor placed outside the sample patient.

In determining the target interference characteristic, in another embodiment, the target interference characteristic may be calculated according to the following expression:

；

Wherein t represents the moment corresponding to the currently calculated feature, For the first preset moment threshold,/>For the second preset moment threshold,/>Representing associated features,/>Representing aortic pressure,/>Representing the pressure of the left ventricle of the heart,Representing the pressure difference between the aortic pressure and the left ventricular pressure,/>、/>、/>、/>、/>、/>All represent preset coefficients.

The differential pressure adjustment module 303 is configured to calculate a differential pressure between the aortic pressure and the left ventricular pressure, determine a deviation value of the differential pressure based on the target disturbance characteristic, and adjust the differential pressure based on the deviation value.

The target disturbance characteristic is used for reflecting the disturbance characteristic of the disturbance of the optical fiber pressure sensor, the disturbance characteristic influences the accuracy of the pressure measurement value of the optical fiber pressure sensor, and the differential pressure value is calculated based on the left ventricle pressure measured by the optical fiber pressure sensor, so that the differential pressure deviation value can be accurately determined based on the target disturbance characteristic.

When determining the differential pressure deviation value, in one implementation manner, the target interference feature may be converted into an interference degree by using a first mapping relationship constructed in advance, where each preset interference feature and a corresponding interference degree are recorded in the first mapping relationship, and the interference degree reflects the interference degree of the interference of the optical fiber pressure sensor in a quantization manner. After the interference degree is obtained, a second mapping relation which is built in advance is utilized to convert the interference degree into a differential pressure deviation value, and the interference degree and the corresponding pressure deviation value are recorded in the second mapping relation.

In another embodiment, the target interference feature may be input into a pre-trained pressure deviation prediction model to obtain a pressure deviation value output by the compensated pressure prediction model, as a deviation value of the differential pressure.

The pressure deviation model is obtained by training an initial neural network model by taking a sample interference characteristic as a training sample and taking an actual deviation value of a sample pressure difference as a training reference, and is used for predicting the compensation pressure of the left ventricle pressure.

The sample interference characteristic is a target interference characteristic of interference suffered by a sample optical fiber pressure sensor integrated in the sample ventricular catheter pump; the sample left ventricular pressure is the left ventricular pressure detected by the sample optical fiber pressure sensor, and the actual compensation pressure of the sample left ventricular pressure is as follows: the pressure difference between the left ventricular pressure detected by the sample optical fiber pressure sensor and the actual left ventricular pressure.

The flow determining module 304 is configured to determine the pump blood flow corresponding to the adjusted pressure difference based on a corresponding relationship between the preset pressure difference and the pump blood flow.

In determining the pump blood flow, in one embodiment, a correspondence between the differential pressure corresponding to the current rotational speed level and the pump blood flow may be determined, and the pump blood flow corresponding to the adjusted differential pressure may be determined as the pump blood flow of the ventricular catheter pump.

In determining the pump blood flow, in another embodiment, a first state parameter indicative of a state of vascular resistance and a second state parameter indicative of a state of vascular inertia may be obtained; based on the first state parameter, the second state parameter, and the adjusted differential pressure, a pump blood flow of the ventricular catheter pump is calculated.

The first state parameter represents the vascular resistance state, the second state parameter represents the vascular inertia state, and the first state parameter and the second state parameter reflect the vascular state from different aspects.

The blood flow rate of the pump is calculated based on the two state parameters and the pressure difference, wherein the two state parameters reflect the blood vessel state from two different aspects, and the pressure difference reflects the blood pressure, so that the calculated blood flow rate of the pump considers the blood pressure condition and the blood vessel state, and the accuracy of calculating the blood flow rate of the pump is improved.

In calculating the pump blood flow rate using the above data, the pump blood flow rate may be calculated according to the following expression:

；

Wherein, Representing the flow of pump blood,/>Representing differential pressure,/>For a preset coefficient, R represents a first state parameter and L represents a second state parameter.

From the above, it can be seen that, with the system provided in this embodiment, the controller included in the system determines the interference characteristic of the interference of the optical fiber pressure sensor by using the correlation characteristic of the correlation characteristic between the left ventricle pressure and the aortic pressure, determines the deviation value of the differential pressure based on the interference characteristic, and adjusts the differential pressure, thereby determining the pump blood flow based on the adjusted differential pressure. Because the correlation characteristic between the left ventricular pressure and the aortic pressure is related to the left ventricular pressure, the characteristic of the interference of the optical fiber pressure sensor can be accurately determined based on the correlation characteristic, so that the accuracy of the determined differential pressure is higher, the differential pressure is adjusted based on the differential pressure, the accuracy of the calculated differential pressure is improved, and the pump blood flow is determined based on the adjusted differential pressure, thereby realizing accurate detection of the pump blood flow of the ventricular catheter pump.

Referring to fig. 4, fig. 4 is a schematic structural diagram of a second controller according to an embodiment of the present application. The interference determination module 302 may include the following feature determination sub-module 402 and the interference determination sub-module 403, based on the embodiment corresponding to fig. 3.

The information acquisition module 401 is configured to acquire left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle.

The information obtaining module 401 is the same as the information obtaining module 301 in the embodiment corresponding to fig. 3, and will not be described herein.

A first feature determining sub-module 402, configured to determine a correlation feature that characterizes a correlation between the left ventricular pressure and the aortic pressure, determine target phases that characterize different motion situations of the heart and are included in a current cardiac cycle, and determine target features that characterize phase characteristics of each target phase based on a correspondence between pre-constructed cardiac motion phases and motion phase feature features.

The above-described target phases are used to characterize different operating conditions of the heart. Within a cardiac cycle, there are phases of systole and diastole, wherein the phases of systole and diastole can be subdivided into different phases, such as isovolumetric contraction, fast ejection, slow ejection, isovolumetric diastole and filling. The heart movement conditions in each stage are different, such as the left ventricle is fast tightened in the systole until the left ventricle pressure is higher than the aortic pressure, the aortic valve is opened, the left ventricle starts to shoot, the early-stage shooting speed is fast, and the later-stage shooting speed is gradually slowed down; when the aortic valve closes, the heart enters diastole until the next systole begins.

In determining the target phase, in one embodiment, a differential pressure between the left ventricular pressure and the aortic pressure may be calculated, and the target phase included in the current cardiac cycle may be determined based on the differential pressure change feature, the corresponding relationship between the time sequence information corresponding to each differential pressure and the cardiac motion phase, which are constructed in advance, and the calculated differential pressure and the time sequence information corresponding to each differential pressure.

In determining the target phase, in another embodiment, the current cardiac cycle may be divided according to each preset duration and the sequence of each preset duration, and the phase obtained by the division is determined as the target phase, where each preset duration corresponds to a different phase.

The target features are used to characterize the phase characteristics of each target phase, which reflect the uniqueness of each target phase. Since the heart motion reflected by each phase is different, each phase is unique from the other phases.

The phase characteristic may be a pressure difference between the left ventricular pressure and the aortic pressure and/or a pressure difference time sequence variation, a correlation between the left ventricular pressure time sequence variation and the aortic pressure time sequence variation, a correlation between the left ventricular pressure time sequence variation and the pressure difference time sequence variation, and a correlation between the aortic pressure time sequence variation and the pressure difference time sequence variation.

When the target characteristics of each target stage are determined based on a pre-established corresponding relationship, the corresponding relationship is a corresponding relationship between the heart motion stage and the motion stage characteristic characteristics, and the motion stage characteristic characteristics corresponding to each heart motion stage reflect the stage characteristics of the motion stage.

The second feature determining submodule 403 is configured to calculate, for each target stage, a degree of matching between target features corresponding to the target stage among features included in the associated features, and determine, as the first feature, a feature for the target stage among the associated features based on the calculated degree of matching.

The matching degree reflects the matching relation between each feature in the associated features and the corresponding target feature of each target stage; the higher the degree of matching, the more matching between the two features is indicated. Because the associated features comprise features with multiple dimensions, and the target features reflect unique stage characteristics of each target stage, the features most suitable for the target stages can be screened and obtained by utilizing the matching relation between each feature contained in the associated features and the target features corresponding to the target stages, and the interference information corresponding to each stage can be determined more specifically.

When calculating the matching degree, the correlation degree between each feature in the correlation features and the target feature corresponding to the target stage can be calculated according to a preset correlation degree algorithm, and the calculated correlation degree is determined to be the matching degree.

When determining the first feature, the feature with the highest matching degree may be determined as the first feature, or the feature with the matching degree larger than the preset matching degree threshold may be determined as the first feature.

The interference determination submodule 404 is configured to determine, for each target stage, a fluctuation characteristic of a first characteristic corresponding to the target stage compared to a fluctuation characteristic of a target characteristic corresponding to the target stage, as a target interference characteristic representing an interference characteristic of the optical fiber pressure sensor in each target stage.

Since the target feature reflects the feature of the stage characteristic of the target stage, the target feature reflects the characteristic of the stage from the own characteristic of the target stage; the first characteristic is a phase characteristic reflecting a target phase based on a relation between the detected left ventricular pressure and the aortic pressure, and the determined fluctuation characteristic is a fluctuation condition reflecting the first characteristic with respect to the target characteristic. Thus, the determined fluctuation feature can accurately reflect the disturbed characteristic in the pressure detection process.

In determining the fluctuation feature, in one embodiment, with the target feature as the reference feature, a feature difference between the first feature and the reference feature may be determined, and the feature difference may be determined as the fluctuation feature.

A differential pressure adjustment module 405 for calculating a differential pressure between the aortic pressure and the left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

The flow determination module 406 is configured to determine a pump blood flow of the ventricular catheter pump based on the adjusted differential pressure.

The 405-406 are the same as the 304-305 in the embodiment corresponding to fig. 3, and are not described here again.

As can be seen from the above, in the present embodiment, since the target feature reflects the feature of the stage characteristic of the target stage, the target feature reflects the characteristic of the stage from the own characteristic of the target stage; the first characteristic is a phase characteristic reflecting a target phase based on a relation between the detected left ventricular pressure and the aortic pressure, and the determined fluctuation characteristic is a fluctuation condition reflecting the first characteristic with respect to the target characteristic. Thus, the determined fluctuation feature can accurately reflect the disturbed characteristic in the pressure detection process.

In the foregoing embodiment corresponding to fig. 4, a third feature determination submodule may be further included before the interference determination submodule. Based on this, referring to fig. 5, fig. 5 is a schematic structural diagram of a third controller according to an embodiment of the present application. The controller includes:

The information acquisition module 501 is configured to acquire left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

a first feature determining sub-module 502, configured to determine a correlation feature that characterizes a correlation characteristic between the left ventricular pressure and the aortic pressure, determine target phases that characterize different motion situations of the heart and are included in a current cardiac cycle, and determine target features that characterize phase characteristics of each target phase based on a correspondence between pre-constructed cardiac motion phases and motion phase feature features.

A second feature determining sub-module 503, configured to calculate, for each target stage, a degree of matching between target features corresponding to the target stage, among features included in the associated features, and determine, as the first feature, a feature for the target stage, among the associated features, based on the calculated degree of matching.

The above 501-503 are the same as 401-403 in the corresponding embodiment of fig. 4, and will not be described again here.

The third feature determining sub-module 504 is configured to calculate, for each target stage, a matching degree between a target feature corresponding to the target stage and a target feature corresponding to another target stage, and determine a first feature corresponding to the other target stage with the highest matching degree as a second feature corresponding to the target stage.

The other target phases mentioned above refer to target phases other than the target phase currently targeted among the determined target phases.

The matching degree reflects the association relation between the target stages, and when the matching degree is highest, the relationship between the two stages is the closest. When calculating the matching degree, the correlation degree between the two features can be calculated according to a preset correlation degree algorithm, and the calculated correlation degree is determined as the matching degree.

The interference determination submodule 505 is specifically configured to, for each target stage, fuse the first feature and the second feature corresponding to the target stage to obtain a fused feature, determine a fluctuation feature of the fused feature corresponding to the target stage compared with the target feature corresponding to the target stage, and use the fluctuation feature as a target interference feature for characterizing an interference characteristic of interference suffered by the optical fiber pressure sensor in each target stage.

Because the target interference feature is determined based on the fused feature in comparison to the fluctuating feature of the target feature, the fused feature fuses the first feature and the second feature corresponding to the target stage, the first feature being for the target stage and the second feature being for the other target stage that is the closest match to the target stage. Therefore, in the application, the two phases of the current target phase and the other target phases which are matched with the current target phase are combined, so that the determined fusion characteristic can reflect the pressure change condition from the whole continuity of the heart motion, and the target interference characteristic can be further accurately determined based on the fusion characteristic.

When the first feature and the second feature are fused, feature stitching can be performed on the first feature and the second feature to serve as fusion features;

When the first feature and the second feature are fused, an intersection feature between the first feature and the second feature can be determined, the first feature and the second feature are updated respectively based on the intersection feature, and the updated first feature and the updated second feature are fused to obtain a fusion feature.

The intersection feature reflects a feature in which a coincidence occurs between the first feature and the second feature. The intersection characteristic can more accurately reflect the detection characteristic of the current target stage because the intersection characteristic is the characteristic appearing between the first characteristic and the second characteristic. And updating the first characteristic and the second characteristic by using the intersection characteristic, so that the accuracy of the updated first characteristic and second characteristic is higher.

A differential pressure adjustment module 506 for calculating a differential pressure between the aortic pressure and the left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

The flow determination module 507 is configured to determine a pump blood flow of the ventricular catheter pump based on the adjusted pressure differential.

The above 506-507 are the same as the above 405-406 in the embodiment corresponding to fig. 4, and are not described here again.

As can be seen from the above, in the present embodiment, since the target interference feature is determined based on the fluctuation feature of the fusion feature compared with the target feature, the fusion feature fuses the first feature and the second feature corresponding to the target stage, the first feature being for the target stage, and the second feature being for the other target stage that is the best match of the target stage. Therefore, in the application, the two phases of the current target phase and the other target phases which are matched with the current target phase are combined, so that the determined fusion characteristic can reflect the pressure change condition from the whole continuity of the heart motion, and the target interference characteristic can be further accurately determined based on the fusion characteristic.

Corresponding to the pump blood flow estimation system based on the ventricular catheter pump, the embodiment of the application also provides a pump blood flow estimation method based on the ventricular catheter pump.

Referring to fig. 6, fig. 6 is a flowchart of a first method for estimating a pump blood flow based on a ventricular catheter pump according to an embodiment of the present application, wherein the method includes steps S601 to S604.

The method provided by the embodiment is applied to a controller in a pump blood flow estimation system, and the pump blood flow estimation system further comprises a ventricular catheter pump and a pressure sensor; the optical fiber pressure sensor is integrated on the blood inlet cage side; and the pressure sensor is arranged outside the patient and is used for detecting the aortic pressure of the patient.

Step S601: and acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in the current cardiac cycle.

Step S602: an associated characteristic that characterizes an associated characteristic between left ventricular pressure and aortic pressure is determined, and a target interference characteristic that characterizes an interference characteristic to which the fiber optic pressure sensor is subject is determined based on the associated characteristic.

Step S603: the differential pressure between the aortic pressure and the left ventricular pressure is calculated, a deviation value of the differential pressure is determined based on the target disturbance characteristic, and the differential pressure is adjusted based on the deviation value.

Step S604: based on the adjusted differential pressure, a pump blood flow of the ventricular catheter pump is determined.

From the above, it can be seen that, with the system provided in this embodiment, the controller included in the system determines the interference characteristic of the interference of the optical fiber pressure sensor by using the correlation characteristic of the correlation characteristic between the left ventricle pressure and the aortic pressure, determines the deviation value of the differential pressure based on the interference characteristic, and adjusts the differential pressure, thereby determining the pump blood flow based on the adjusted differential pressure. Because the correlation characteristic between the left ventricular pressure and the aortic pressure is related to the left ventricular pressure, the characteristic of the interference of the optical fiber pressure sensor can be accurately determined based on the correlation characteristic, so that the accuracy of the determined differential pressure is higher, the differential pressure is adjusted based on the differential pressure, the accuracy of the calculated differential pressure is improved, and the pump blood flow is determined based on the adjusted differential pressure, thereby realizing accurate detection of the pump blood flow of the ventricular catheter pump.

In one embodiment of the present application, determining the pump blood flow of the ventricular catheter pump based on the adjusted pressure difference in step S604 includes:

acquiring a first state parameter representing a vascular resistance state and a second state parameter representing a vascular inertia state; calculating a pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted pressure differential.

The blood flow rate of the pump is calculated based on the two state parameters and the pressure difference, wherein the two state parameters reflect the blood vessel state from two different aspects, and the pressure difference reflects the blood pressure, so that the calculated blood flow rate of the pump considers the blood pressure condition and the blood vessel state, and the accuracy of calculating the blood flow rate of the pump is improved.

In one embodiment of the present application, calculating the pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted pressure difference includes:

The pump blood flow of the ventricular catheter pump is calculated according to the following expression:

；

Wherein, Representing the flow of pump blood,/>Representing differential pressure,/>For a preset coefficient, R represents a first state parameter and L represents a second state parameter.

Referring to fig. 7, fig. 7 is a flowchart of a second method for estimating a pump blood flow based on a ventricular catheter pump according to an embodiment of the present application, wherein the method includes steps S701 to S706.

Step S701: acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

Step S702: determining the association characteristic representing the association characteristic between the left ventricular pressure and the aortic pressure, determining the target phases representing different motion conditions of the heart contained in the current cardiac cycle, and determining the target characteristic representing the phase characteristic of each target phase based on the corresponding relation between the pre-constructed cardiac motion phases and the motion phase characteristic;

Step S703: for each target stage, calculating the matching degree between target features corresponding to the target stage in the features contained in the associated features, and determining the features for the target stage in the associated features as first features based on the calculated matching degree;

step S704: for each target stage, determining a fluctuation characteristic of a first characteristic corresponding to the target stage compared with a target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage.

Step S705: calculating a differential pressure between the aortic pressure and left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

Step S706: based on the adjusted differential pressure, a pump blood flow of the ventricular catheter pump is determined.

As can be seen from the above, in the present embodiment, since the target feature reflects the feature of the stage characteristic of the target stage, the target feature reflects the characteristic of the stage from the own characteristic of the target stage; the first characteristic is a phase characteristic reflecting a target phase based on a relation between the detected left ventricular pressure and the aortic pressure, and the determined fluctuation characteristic is a fluctuation condition reflecting the first characteristic with respect to the target characteristic. Thus, the determined fluctuation feature can accurately reflect the disturbed characteristic in the pressure detection process.

Referring to fig. 8, fig. 8 is a flowchart of a third method for estimating a pump blood flow based on a ventricular catheter pump according to an embodiment of the present application, wherein the method includes the following steps S801 to S807.

Step S801: acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

step S802: determining the association characteristic representing the association characteristic between the left ventricular pressure and the aortic pressure, determining the target phases representing different motion conditions of the heart contained in the current cardiac cycle, and determining the target characteristic representing the phase characteristic of each target phase based on the corresponding relation between the pre-constructed cardiac motion phases and the motion phase characteristic;

Step S803: for each target stage, calculating the matching degree between target features corresponding to the target stage in the features contained in the associated features, and determining the features for the target stage in the associated features as first features based on the calculated matching degree;

Step S804: for each target stage, calculating the matching degree between the target feature corresponding to the target stage and the target features corresponding to other target stages, and determining the first features corresponding to other target stages with the highest matching degree as the second features corresponding to the target stage;

Step S805: and aiming at each target stage, fusing the first characteristic and the second characteristic corresponding to the target stage to obtain a fused characteristic, and determining the fluctuation characteristic of the fused characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic for representing the interference characteristic of the optical fiber pressure sensor in each target stage.

Step S806: calculating a differential pressure between the aortic pressure and left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

step S807: based on the adjusted differential pressure, a pump blood flow of the ventricular catheter pump is determined.

As can be seen from the above, in the present embodiment, since the target interference feature is determined based on the fluctuation feature of the fusion feature compared with the target feature, the fusion feature fuses the first feature and the second feature corresponding to the target stage, the first feature being for the target stage, and the second feature being for the other target stage that is the best match of the target stage. Therefore, in the application, the two phases of the current target phase and the other target phases which are matched with the current target phase are combined, so that the determined fusion characteristic can reflect the pressure change condition from the whole continuity of the heart motion, and the target interference characteristic can be further accurately determined based on the fusion characteristic.

In an embodiment of the present application, for each target stage, fusing a first feature and a second feature corresponding to the target stage to obtain a fused feature, including:

For each target stage, determining an intersection characteristic between a first characteristic corresponding to the target stage and a second characteristic corresponding to the target stage, and fusing the updated first characteristic and second characteristic based on the first characteristic and the second characteristic corresponding to the intersection characteristic respectively to serve as fusion characteristics.

The intersection feature reflects a feature in which a coincidence occurs between the first feature and the second feature. The intersection characteristic can more accurately reflect the detection characteristic of the current target stage because the intersection characteristic is the characteristic appearing between the first characteristic and the second characteristic. And updating the first characteristic and the second characteristic by using the intersection characteristic, so that the accuracy of the updated first characteristic and second characteristic is higher.

Corresponding to the pump blood flow estimation system based on the ventricular catheter pump, the embodiment of the application also provides the ventricular catheter pump.

The ventricular catheter pump comprises a driving assembly, a pumping assembly, a blood inlet cage, a blood outlet cage and an optical fiber pressure sensor; when the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient.

In yet another embodiment of the present application, a computer readable storage medium is provided, in which a computer program is stored, which when executed by a processor, implements the pump blood flow estimation method provided by the embodiment of the present application.

In yet another embodiment of the present application, a computer program product comprising instructions which, when run on a computer, cause the computer to perform the method of estimating pump blood flow provided by the embodiments of the present application is also provided.

From the above, it can be seen that, with the system provided in this embodiment, the controller included in the system determines the interference characteristic of the interference of the optical fiber pressure sensor by using the correlation characteristic of the correlation characteristic between the left ventricle pressure and the aortic pressure, determines the deviation value of the differential pressure based on the interference characteristic, and adjusts the differential pressure, thereby determining the pump blood flow based on the adjusted differential pressure. Because the correlation characteristic between the left ventricular pressure and the aortic pressure is related to the left ventricular pressure, the characteristic of the interference of the optical fiber pressure sensor can be accurately determined based on the correlation characteristic, so that the accuracy of the determined differential pressure is higher, the differential pressure is adjusted based on the differential pressure, the accuracy of the calculated differential pressure is improved, and the pump blood flow is determined based on the adjusted differential pressure, thereby realizing accurate detection of the pump blood flow of the ventricular catheter pump.

In the above embodiments, it may be implemented in whole or in part by software, hardware, firmware, or any combination thereof. When implemented in software, may be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When loaded and executed on a computer, produces a flow or function in accordance with embodiments of the present application, in whole or in part. The computer may be a general purpose computer, a special purpose computer, a computer network, or other programmable apparatus. The computer instructions may be stored in or transmitted from one computer-readable storage medium to another, for example, by wired (e.g., coaxial cable, optical fiber, digital Subscriber Line (DSL)), or wireless (e.g., infrared, wireless, microwave, etc.). The computer readable storage medium may be any available medium that can be accessed by a computer or a data storage device such as a server, data center, etc. that contains an integration of one or more available media. The usable medium may be a magnetic medium (e.g., floppy disk, hard disk, tape), an optical medium (e.g., DVD), or a semiconductor medium (e.g., solid state disk Solid STATE DISK (SSD)), etc.

It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.

In this specification, each embodiment is described in a related manner, and identical and similar parts of each embodiment are all referred to each other, and each embodiment mainly describes differences from other embodiments. In particular, for the method, ventricular catheter pump, controller, computer readable storage medium embodiments, since they are substantially similar to the method embodiments, the description is relatively simple, as relevant to see the partial description of the method embodiments.

The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the scope of the present application. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application are included in the protection scope of the present application.

Claims (6)

1. A ventricular catheter pump-based pump blood flow estimation system, the system comprising: a ventricular catheter pump, a controller, a pressure sensor, the ventricular catheter pump comprising: the device comprises a driving assembly, a pumping assembly, a blood inlet cage, a blood outlet cage and an optical fiber pressure sensor; wherein:

When the ventricular catheter pump is implanted into the heart to run, the driving assembly drives the pumping assembly to rotate, blood in the left ventricle is pumped from a blood inlet cage positioned in the left ventricle to a blood outlet cage positioned in the aorta, and the blood outlet cage is arranged in the main artery, and the optical fiber pressure sensor is integrated on the side of the blood inlet cage and is used for detecting the pressure of the left ventricle of a patient;

The pressure sensor is arranged outside the patient and is used for detecting the aortic pressure of the patient;

the controller comprises an information acquisition module, an interference determination module, a differential pressure adjustment module and a flow determination module, wherein:

The information acquisition module is used for acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in the current cardiac cycle;

a disturbance determining module for determining a correlation characteristic characterizing a correlation characteristic between left ventricular pressure and aortic pressure, and determining a target disturbance characteristic characterizing a disturbance characteristic to which the optical fiber pressure sensor is disturbed based on the correlation characteristic;

a differential pressure adjustment module for calculating a differential pressure between the aortic pressure and the left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

a flow determination module for determining a pump blood flow of the ventricular catheter pump based on the adjusted differential pressure;

The flow determination module is specifically used for acquiring a first state parameter representing a vascular resistance state and a second state parameter representing a vascular inertia state; calculating a pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted differential pressure;

The interference determination module includes:

The first characteristic determining submodule is used for determining the association characteristic representing the association characteristic between the left ventricular pressure and the aortic pressure, determining target phases representing different movement conditions of the heart contained in the current cardiac cycle, and determining the target characteristic representing the phase characteristic of each target phase based on the corresponding relation between the pre-constructed heart movement phases and the movement phase characteristic;

a second feature determining sub-module, configured to calculate, for each target stage, a degree of matching between target features corresponding to the target stage, from among features included in the associated feature, and determine, based on the calculated degree of matching, a feature for the target stage, from among the associated features, as a first feature;

And the interference determination submodule is used for determining a fluctuation characteristic of the first characteristic corresponding to each target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the optical fiber pressure sensor in each target stage.

2. The system according to claim 1, wherein the flow determination module is configured to calculate a pump blood flow of the ventricular catheter pump according to the following expression:

；

Wherein, Representing the flow of pump blood,/>Representing differential pressure,/>For the preset coefficient,/>A first state parameter is indicated and a first state parameter is indicated,Representing a second state parameter.

3. The system of claim 1, wherein the system further comprises a controller configured to control the controller,

The interference determination module further includes a third feature determination sub-module:

the third feature determining submodule is configured to calculate, for each target stage, a matching degree between a target feature corresponding to the target stage and a target feature corresponding to another target stage, and determine, as a second feature corresponding to the target stage, a first feature corresponding to the other target stage with the highest matching degree, before the interference determining submodule;

The interference determination submodule is specifically configured to, for each target stage, fuse a first feature and a second feature corresponding to the target stage to obtain a fused feature, determine a fluctuation feature of the fused feature corresponding to the target stage compared with a target feature corresponding to the target stage, and use the fluctuation feature as a target interference feature for representing interference characteristics of the optical fiber pressure sensor in each target stage.

4. The pump blood flow estimation method based on the ventricular catheter pump is characterized by being applied to a controller in a pump blood flow estimation system, wherein the pump blood flow estimation system further comprises a ventricular catheter pump and a pressure sensor; the optical fiber pressure sensor is integrated on the blood inlet cage side; a pressure sensor, disposed outside the patient, for detecting aortic pressure of the patient; the method comprises the following steps:

acquiring left ventricular pressure detected by the optical fiber pressure sensor and aortic pressure detected by the pressure sensor in a current cardiac cycle;

Determining an associated feature characterizing an associated characteristic between left ventricular pressure and aortic pressure, determining a target interference feature characterizing an interference characteristic of interference suffered by the fiber optic pressure sensor based on the associated feature;

calculating a differential pressure between the aortic pressure and left ventricular pressure, determining a deviation value of the differential pressure based on the target disturbance characteristic, and adjusting the differential pressure based on the deviation value;

Determining a pump blood flow of the ventricular catheter pump based on the adjusted differential pressure;

the determining the pump blood flow of the ventricular catheter pump based on the adjusted differential pressure comprises:

Acquiring a first state parameter representing a vascular resistance state and a second state parameter representing a vascular inertia state;

Calculating a pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted differential pressure;

the determining, based on the correlation characteristic, a target interference characteristic characterizing an interference characteristic of the interference experienced by the fiber optic pressure sensor, comprising:

Determining target phases which are contained in the current cardiac cycle and represent different movement conditions of the heart, and determining target features representing phase characteristics of each target phase based on a corresponding relation between a pre-constructed heart movement phase and movement phase characteristic features;

For each target stage, calculating the matching degree between target features corresponding to the target stage in the features contained in the associated features, and determining the features for the target stage in the associated features as first features based on the calculated matching degree;

for each target stage, determining a fluctuation characteristic of a first characteristic corresponding to the target stage compared with a target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage.

5. The method of claim 4, wherein calculating the pump blood flow of the ventricular catheter pump based on the first state parameter, the second state parameter, and the adjusted pressure differential comprises:

The pump blood flow of the ventricular catheter pump is calculated according to the following expression:

；

Wherein, Representing the flow of pump blood,/>Representing differential pressure,/>For the preset coefficient,/>Representing the first state parameter,/>Representing a second state parameter.

6. The method of claim 4, wherein the step of determining the position of the first electrode is performed,

Before determining, for each target stage, the fluctuation characteristic of the first characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as the target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage, the method further includes:

For each target stage, calculating the matching degree between the target feature corresponding to the target stage and the target features corresponding to other target stages, and determining the first features corresponding to other target stages with the highest matching degree as the second features corresponding to the target stage;

For each target stage, determining the fluctuation characteristic of the first characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic representing the interference characteristic of the interference suffered by the optical fiber pressure sensor in each target stage comprises the following steps:

and aiming at each target stage, fusing the first characteristic and the second characteristic corresponding to the target stage to obtain a fused characteristic, and determining the fluctuation characteristic of the fused characteristic corresponding to the target stage compared with the target characteristic corresponding to the target stage as a target interference characteristic for representing the interference characteristic of the optical fiber pressure sensor in each target stage.