CN117705542B - Specimen pretreatment system - Google Patents

Abstract

The invention discloses a specimen pretreatment system, which comprises a frame, a specimen cup treatment device, a specimen cup storage device, a slide storage device and a triple sampling device, wherein the triple sampling device comprises three sampling devices, the specimen cup storage device, a specimen cup treatment turntable and the slide storage device are sequentially arranged around a rotating bracket, the three sampling devices are distributed in a triangular mode around the rotating center of the rotating bracket, the included angle between two adjacent sampling devices and the rotating center of the rotating bracket is 120 degrees, the rotating bracket drives the three sampling devices to rotate above the specimen cup storage device, the specimen cup treatment turntable and the slide storage device, and the three sampling devices can sequentially sleeve a sampling head on a specimen cup limiting groove, extract specimens on the specimen cup through the sampling head, coat the specimens on the sampling head on a slide and discard the sampling head. Every time the rotating bracket drives three sampling devices to synchronously rotate for 120 degrees, the processing work of one specimen can be completed, and the specimen processing efficiency is effectively improved.

Description

Specimen pretreatment system

Technical Field

The invention relates to the technical field of microbial treatment, in particular to a specimen pretreatment system.

Background

Both the cultivation and detection of microorganisms require the manipulation of microbial specimens, including sampling and transfer of specimens. At present, for the specimens with a small number, a manual operation mode is adopted, so that the efficiency is low, and the risks of cross contact of the specimens are influenced, and for the specimens with infectious properties, the risks of infection of operators are also influenced; for batch specimens with a large number, professional processing equipment is needed for processing, but the current processing equipment mostly adopts a sampling mechanism which moves back and forth for transferring specimens, so that the efficiency is low.

Disclosure of Invention

The present invention aims to solve at least one of the technical problems existing in the prior art. Therefore, the invention provides a specimen pretreatment system, which has higher specimen treatment efficiency.

The specimen pretreatment system comprises a frame, a specimen cup treatment device, a sampling head storage device, a slide storage device and a triple sampling device, wherein a workbench is arranged on the frame, and a rotating bracket is arranged on the workbench; the specimen cup processing device comprises a specimen cup processing rotary table which is rotatably arranged on the workbench, wherein a plurality of specimen cup limiting grooves which are annularly distributed are formed in the specimen cup processing rotary table and are used for limiting specimen cups; the sampling head storage device is arranged on the workbench, a plurality of sampling head limiting grooves are formed in the sampling head storage device, and the sampling head limiting grooves are used for limiting the sampling heads; the slide storage device is arranged on the workbench and is provided with a plurality of slide limiting grooves which are used for limiting slides; the triple sampling device comprises three sampling devices, wherein the sampling head storage devices, the sample cup processing turntables and the slide storage devices are sequentially arranged around the rotating support, the three sampling devices are all arranged on the rotating support in a lifting mode, the three sampling devices are distributed in a triangular mode around the rotating center of the rotating support, the included angles of the adjacent two sampling devices and the rotating center of the rotating support are 120 degrees, the rotating support drives the three sampling devices to rotate above the sampling head storage devices, the sample cup processing turntables and the slide storage devices, and the three sampling devices can sequentially sleeve sampling heads on the sampling head limiting grooves, extract samples on the sample cups through the sampling heads, coat the samples on the sampling heads on the slides and discard the sampling heads.

Has at least the following beneficial effects:

The three sampling devices can sequentially complete the three operation steps of assembling the sampling head, extracting the sample and coating the sample on the slide, and the three operation steps of assembling the sampling head, extracting the sample and coating the sample on the slide are completed, namely, the processing of one sample is completed. Every time the rotating bracket drives three sampling devices to synchronously rotate for 120 degrees, the processing work of one specimen can be completed, and the specimen processing efficiency is effectively improved.

According to some embodiments of the invention, the sampling device comprises a support frame, a first lifting driving mechanism, a lifting frame and an injection mechanism, wherein the support frame is connected with the rotating support frame, the lifting frame is connected with the support frame through a first vertical sliding mechanism, the first lifting driving mechanism is arranged on the support frame, the output end of the first lifting driving mechanism is connected with the lifting frame, the injection mechanism is arranged on the lifting frame, the injection mechanism comprises a needle cylinder connected with the lifting frame, and the lower end of the needle cylinder can be inserted into the upper port of the sampling head to be sleeved with the sampling head.

According to some embodiments of the invention, the sampling device further comprises a blanking plate and an elastic piece, the blanking plate is connected with the supporting frame through a second vertical sliding mechanism, one end of the blanking plate is provided with a U-shaped groove, one end of the blanking plate is sleeved on the needle cylinder through the U-shaped groove, two ends of the elastic piece are respectively connected with the supporting frame and the blanking plate, and one end of the blanking plate can be propped against the upper end face of the sampling head to fade the sampling head from the needle cylinder.

According to some embodiments of the invention, the injection mechanism further comprises a piston rod, a second lifting driving mechanism and a first rotation driving mechanism, wherein the second lifting driving mechanism and the first rotation driving mechanism are arranged on the lifting frame, the output end of the second lifting driving mechanism is connected with the upper end of the piston rod, the lower end of the piston rod is matched with the needle cylinder, and the output end of the first rotation driving mechanism is in transmission connection with the needle cylinder.

According to some embodiments of the invention, the sampling device further comprises a first horizontal linear driving mechanism arranged on the rotating support, the support frame is connected with the rotating support through a first horizontal sliding mechanism, the sliding direction of the first horizontal sliding mechanism passes through the rotating center of the rotating support, and the output end of the first horizontal linear driving mechanism is connected with the support frame.

According to some embodiments of the invention, there is further included a sample head collection cartridge, the sample head collection cartridge having a collection tube attached thereto, the collecting pipe is arranged on the workbench and is positioned between the slide storage device and the sampling head storage device.

According to some embodiments of the invention, the specimen cup processing apparatus further comprises a cover opening mechanism, a cover lifting mechanism and a cover closing mechanism, wherein the cover opening mechanism, the cover lifting mechanism and the cover closing mechanism are sequentially arranged around the specimen cup processing turntable, the cover opening mechanism is used for unscrewing a cup cover of the specimen cup, the cover lifting mechanism is used for lifting and closing the cup cover on the specimen cup, and the cover closing mechanism is used for screwing the cup cover.

According to some embodiments of the invention, the cover lifting mechanism comprises a fourth rotary driving mechanism, a swinging member, an L-shaped rod and a sucker, wherein the fourth rotary driving mechanism is arranged on the workbench, the swinging member is rotatably arranged on the workbench and is in transmission connection with the output end of the fourth rotary driving mechanism, the swinging member is connected with one end of the L-shaped rod, and the other end of the L-shaped rod is connected with the sucker.

According to some embodiments of the invention, the sample cup feeding device is arranged on the workbench and beside the sample cup processing turntable, and is used for transferring the sample cup to the sample cup limit groove and taking off the sample cup from the sample cup limit groove.

According to some embodiments of the invention, the sampling head storage device comprises a seventh horizontal linear driving mechanism, a sixth rotary driving mechanism and a sampling head turntable, wherein the seventh horizontal linear driving mechanism is arranged on the workbench, the output end of the seventh horizontal linear driving mechanism is connected with the sixth rotary driving mechanism, the output end of the sixth rotary driving mechanism is upwards arranged and is in transmission connection with the sampling head turntable, and the sampling head limiting groove is formed in the sampling head turntable.

Additional aspects and advantages of the invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention.

Drawings

The invention is further described with reference to the accompanying drawings and examples, in which:

FIG. 1 is a schematic view of a specimen pretreatment system according to an embodiment of the present invention after hiding a specimen cup feeding device;

FIG. 2 is a schematic top view of a specimen pretreatment system of FIG. 1;

FIG. 3 is a schematic view of a specimen pretreatment system according to an embodiment of the present invention after a slide storage device is hidden;

FIG. 4 is a schematic view of the partial structure at A in FIG. 3;

FIG. 5 is a schematic view showing the structure of a rotating rack and a sampling device in a specimen pretreatment system according to an embodiment of the present invention;

FIG. 6 is a schematic view of a cover lifting mechanism in a sample pretreatment system according to an embodiment of the present invention;

FIG. 7 is a schematic diagram of a sample head storage device in a sample pretreatment system according to an embodiment of the present invention;

Reference numerals:

A specimen cup 1, a sampling head 2, a slide 3, a rack 100, a table 110, a rotating rack 111, a specimen cup processing apparatus 200, a specimen cup processing turntable 210, a specimen cup limit groove 211, a cover opening mechanism 220, a first rack 221, a fourth lift driving mechanism 222, a second rotary driving mechanism 223, a first cover opening fastener 224, a first cup fixing mechanism 225, a cover lifting mechanism 230, a fourth rotary driving mechanism 231, a swinging member 232, an L-shaped rod 233, a suction cup 234, a cover closing mechanism 240, a sampling head storage apparatus 300, a sampling head limit groove 310, a seventh horizontal linear driving mechanism 320, a sixth rotary driving mechanism 330, a sampling head turntable 340, a slide storage apparatus 400, a slide limit groove 410, a sampling apparatus 500, a support frame 510, a first lift driving mechanism 520, a lift frame 530, an injection mechanism 540, a syringe 541, a piston rod 542, a second lift driving mechanism 543, a first rotary driving mechanism 544, a blanking plate 550, an elastic member 560, a first horizontal linear driving mechanism 570, a first vertical sliding mechanism 580, a first horizontal sliding mechanism 590, a sampling head collecting box 600, a collecting pipe 610, a collecting pipe position adjusting apparatus 700, a third linear driving mechanism 700, a fifth linear driving mechanism 820, a fifth linear driving mechanism 740, a specimen cup position adjusting apparatus 700, a fifth linear driving mechanism 840, a specimen cup holding apparatus 730, a fifth linear driving mechanism 840.

Detailed Description

Embodiments of the present invention are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the invention.

In the description of the present invention, it should be understood that references to orientation descriptions such as upper, lower, front, rear, left, right, etc. are based on the orientation or positional relationship shown in the drawings, are merely for convenience of description of the present invention and to simplify the description, and do not indicate or imply that the apparatus or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention.

In the description of the present invention, plural means two or more. The description of the first and second is for the purpose of distinguishing between technical features only and should not be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated or implicitly indicating the precedence of the technical features indicated.

In the description of the present invention, unless explicitly defined otherwise, terms such as arrangement, installation, connection, etc. should be construed broadly and the specific meaning of the terms in the present invention can be reasonably determined by a person skilled in the art in combination with the specific contents of the technical scheme.

Referring to fig. 1,2 and 6, it can be seen that the specimen cup 1 is a common component, and the specimen cup 1 includes a cup body and a cup cover. The sampling head 2 is a common consumable, the sampling head 2 is integrally tubular, and the sampling head 2 is provided with an upper port and a lower port. Slide 3 is a common component.

Referring to fig. 1 to 4, the invention discloses a specimen pretreatment system, which comprises a frame 100, a specimen cup treatment device 200, a sampling head storage device 300, a slide storage device 400 and a triple sampling device, wherein a workbench 110 is arranged on the frame 100, and a rotary bracket 111 is arranged on the workbench 110; the specimen cup processing device 200 comprises a specimen cup processing rotary table 210 rotatably arranged on the workbench 110, wherein a plurality of specimen cup limiting grooves 211 distributed annularly are arranged on the specimen cup processing rotary table 210, and the specimen cup limiting grooves 211 are used for limiting the specimen cup 1; the sampling head storage device 300 is arranged on the workbench 110, a plurality of sampling head limiting grooves 310 are formed in the sampling head storage device 300, and the sampling head limiting grooves 310 are used for limiting the sampling heads 2; the slide storage device 400 is arranged on the workbench 110, a plurality of slide limiting grooves 410 are arranged on the slide storage device 400, and the slide limiting grooves 410 are used for limiting the slide 3; the triple sampling device comprises three sampling devices 500, wherein the sampling head storage device 300, the sample cup processing turntable 210 and the slide storage device 400 are sequentially arranged around the rotating support 111, the three sampling devices 500 are all arranged on the rotating support 111 in a lifting mode, the three sampling devices 500 are distributed in a triangular mode around the rotating center of the rotating support 111, the included angles between two adjacent sampling devices 500 and the rotating center of the rotating support 111 are 120 degrees, the rotating support 111 drives the three sampling devices 500 to rotate above the sampling head storage device 300, the sample cup processing turntable 210 and the slide storage device 400, the three sampling devices 500 can sequentially sleeve the sampling head 2 on the sampling head limiting groove 310, extract samples on the sample cup 1 through the sampling head 2, coat the samples on the sampling head 2 on the slide 3 and discard the sampling head 2.

When the specimen pretreatment system works, firstly, a specimen cup 1 bearing a specimen is placed in a specimen cup limit groove 211 on a specimen cup processing rotary table 210, a sampling head 2 is placed in a sampling head limit groove 310 of a sampling head storage device 300, and an empty slide 3 is placed in a slide limit groove 410 on a slide storage device 400.

When the specimen cup processing turntable 210 rotates, the specimen cup 1 from which the specimen is to be extracted can be transferred to the extraction station, so that the sampling device 500 lifts the specimen away, then the specimen cup processing turntable 210 continues to rotate, the specimen cup 1 from which the specimen has been lifted away is transferred, and then a new specimen cup 1 from which the specimen is to be extracted is transferred to the extraction station.

The rotating rack 111 drives the three sampling devices 500 to rotate, and the three sampling devices 500 rotate above the sampling head storage device 300, the specimen cup processing turntable 210 and the slide storage device 400, so that each sampling device 500 passes above the sampling head storage device 300, the specimen cup processing turntable 210 and the slide storage device 400 in sequence.

It will be appreciated that for convenience in describing the operation of the sampling devices, three sampling devices 500 will be referred to as a first sampling device, a second sampling device, and a third sampling device in that order. Initially, the first sampling device, the second sampling device, and the third sampling device are above the sample head magazine 300, the specimen cup handling carousel 210, and the slide magazine 400, respectively.

The first sampling device is sleeved with a sampling head 2 on a sampling head limiting groove 310; then, the rotating bracket 111 drives the first sampling device, the second sampling device and the third sampling device to synchronously rotate for 120 degrees, so that the first sampling device carries the sampling head 2 to be transferred to the upper part of the specimen cup processing turntable 210, namely to an extraction station, the first sampling device extracts the specimen in the specimen cup 1 through the sampling head 2, the second sampling device is transferred to the upper part of the sampling head storage device 300, the second sampling device is sleeved with the sampling head 2 on the sampling head limiting groove 310, and the third sampling device is transferred to the upper part of the slide storage device 400; then, the rotating bracket 111 drives the first sampling device, the second sampling device and the third sampling device to synchronously rotate again by 120 degrees, the first sampling device carries the sampling head 2 and the sample to be transferred to the upper side of the slide storage device 400, namely to the smear station, the first sampling device coats the sample on the slide 3 on the slide storage device 400 through the sampling head 2, so that the processing work of one sample is completed, the second sampling device carries the sampling head 2 to be transferred to the extraction station, the second sampling device extracts the sample in the sample cup 1 through the sampling head 2, the third sampling device is transferred to the upper side of the sampling head storage device 300, and the third sampling device also sleeves the sampling head 2 on the sampling head limiting groove 310.

Next, the rotating bracket 111 drives the first sampling device, the second sampling device and the third sampling device synchronously rotate for 120 degrees again, so that the first sampling device resets, the first sampling device discards the sampling head 2 which finishes the smear work for the glass slide 3 in the process of transferring the first sampling device from the upper side of the glass slide storage device 400 to the upper side of the sampling head storage device 300, so that a new sampling head 2 can be sleeved again for carrying out the next round of sample processing work, and the like.

Referring to fig. 5, in some embodiments thereof, a sampling device 500 includes a support frame 510, a first lift drive mechanism 520, a lift frame 530, and an injection mechanism 540. The support frame 510 is connected with the runing rest 111, and the runing rest 111 supports support frame 510 and drives support frame 510 and rotate, and the crane 530 is connected with support frame 510 through first vertical sliding mechanism 580, and first lift actuating mechanism 520 is located on support frame 510, and the output of first lift actuating mechanism 520 is connected with crane 530, and injection mechanism 540 is located on crane 530, and injection mechanism 540 includes the cylinder 541 of being connected with crane 530, and the upper port that can insert sampling head 2 of lower extreme of cylinder 541 is in order to cup joint sampling head 2.

The first lifting driving mechanism 520 drives the lifting frame 530 to lift on the supporting frame 510, the lifting frame 530 drives the syringe 541 to lift, and the first vertical sliding mechanism 580 plays a role in guiding the lifting frame 530 to lift, so as to avoid the horizontal deviation between the lifting frame 530 and the syringe 541. When the rotary support 111 drives the sampling device 500 to rotate, the needle cylinder 541 faces the sampling head 2 in one sampling head limiting slot 310 of the sampling head storage device 300, the needle cylinder 541 descends to insert the sampling head 2 into the upper port of the needle cylinder 541, and then the needle cylinder 541 ascends to lift the sampling head 2 from the sampling head limiting slot 310.

The first vertical sliding mechanism 580 includes a first sliding rail and a first sliding block that are matched with each other, the first sliding rail is vertically arranged, one of the first sliding rail and the first sliding block is connected with the supporting frame 510, and the other is connected with the lifting frame 530.

Referring to fig. 5, the first lift driving mechanism 520 is a screw pair mechanism. The screw pair mechanism comprises a guide sliding mechanism, a first motor, a first screw rod connected with the first screw rod in a transmission manner and a first screw rod nut arranged on the first screw rod, wherein the first screw rod nut is connected with the guide sliding mechanism, and the sliding direction of the guide sliding mechanism is parallel to the length direction of the first screw rod. In this embodiment, the guiding sliding mechanism is a first vertical sliding mechanism 580, the first motor is disposed on the support frame 510, the first screw nut is connected with the lifting frame 530, the first motor drives the first screw to rotate, and the first screw forces the first screw nut and the lifting frame 530 to perform lifting motion. Specifically, the first slide rail and the first slider are respectively connected with the support frame 510 and the first lead screw nut/lifter 530.

In some embodiments, the sampling device 500 further includes a blanking plate 550, one end of the blanking plate 550 is provided with a U-shaped groove, one end of the blanking plate 550 is sleeved on the syringe 541 through the U-shaped groove, one end of the blanking plate 550 can abut against the upper end face of the sampling head 2, and when the syringe 541 rises relative to the blanking plate 550, one end of the blanking plate 550 abuts against the upper end face of the sampling head 2, so that the sampling head 2 is removed from the syringe 541, and the sampling device 500 finishes discarding the sampling head 2.

In order to avoid interference between the blanking plate 550 and the sampling head storage device 300, the specimen cup processing turntable 210 and the slide storage device 400, the position of the blanking plate 550 cannot be too low, but it is conceivable that the lower end of the syringe 541 is located below the lifting frame 530 to ensure that the lower end of the syringe 541 can be inserted into the upper port of the sampling head 2, and one end of the blanking plate 550 is sleeved on the syringe 541 through a U-shaped groove, if the height of the blanking plate 550 is too high, the situation that the lifting frame 530 impacts the blanking plate 550 may occur, or even the situation that the lower end of the syringe 541 cannot be inserted into the upper port of the sampling head 2 because of too small descending height of the syringe 541 may occur.

Referring to fig. 5, the sampling device 500 further includes an elastic member 560, where the blanking plate 550 is connected to the supporting frame 510 through a second vertical sliding mechanism, so that the blanking plate 550 can perform lifting movement on the supporting frame 510, two ends of the elastic member 560 are respectively connected to the supporting frame 510 and the blanking plate 550, the blanking plate 550 is in floating connection with the supporting frame 510, and when the elastic member 560 is in a natural state, the blanking plate 550 is in an initial position.

It is conceivable that the elastic member 560 is a tension spring. The elevating frame 530 is provided on a side of the support frame 510 away from the rotation center of the rotation bracket 111. The second vertical sliding mechanism comprises a second sliding rail and a second sliding block which are matched with each other, the second sliding rail is vertically arranged on the supporting frame 510 and beside the lifting frame 530, the second sliding block is connected with the other end of the blanking plate 550 through a side plate, and the blanking plate 550 is horizontally arranged.

The sampling device 500 works as follows, the blanking plate 550 is in the initial position, when the sampling device 500 needs to take the sampling head 2, the first lifting driving mechanism 520 drives the lifting frame 530 and the syringe 541 to descend, the lifting frame 530 abuts against the blanking plate 550 and drives the blanking plate 550 to descend, the elastic piece 560 is stretched until the lower end of the syringe 541 is inserted into the upper port of the sampling head 2, then the first lifting driving mechanism 520 drives the lifting frame 530 and the syringe 541 to ascend, the syringe 541 lifts the sampling head 2, the lifting frame 530 does not descend the blanking plate 550 any more, at this time, the elastic piece 560 is restored, and the blanking plate 550 is lifted to the initial position.

When the sampling device 500 needs to discard the sampling head 2, the first lifting driving mechanism 520 drives the lifting frame 530 and the needle cylinder 541 to lift, the needle cylinder 541 carries the sampling head 2 to lift, so that the upper end surface of the sampling head 2 abuts against the lower surface of the blanking plate 550, the blanking plate 550 is not lifted greatly after being in the initial position, the needle cylinder 541 and the sampling head 2 lift relatively to the blanking plate 550, and the blanking plate 550 can fade the sampling head 2 from the needle cylinder 541.

Compared with the scheme of fixing the height of the blanking plate 550, the blanking plate 550 is arranged in a floating mode, so that the initial position of the blanking plate 550 is higher, interference of the blanking plate 550 with other components is avoided, the blanking plate 550 can descend along with the lifting frame 530 and the injection mechanism 540, the length of the needle cylinder 541 is not required to be set longer, and the strokes of the lifting frame 530 and the injection mechanism 540 are long enough to enable the needle cylinder 541 to be sleeved and fade the sampling head 2.

Referring to fig. 5, in some embodiments, the injection mechanism 540 further includes a piston rod 542, a second lifting driving mechanism 543 and a first rotation driving mechanism 544, both of which are disposed on the lifting frame 530, the second lifting driving mechanism 543 and the first rotation driving mechanism 544 lift synchronously with the lifting frame 530 and the syringe 541, an output end of the second lifting driving mechanism 543 is connected to an upper end of the piston rod 542, a lower end of the piston rod 542 cooperates with the syringe 541, the piston rod 542 and the syringe 541 form a pump structure, when the second lifting driving mechanism 543 drives the piston rod 542 to rise, a negative pressure is formed in the syringe 541 and the sampling head 2, thereby sucking the specimen in the specimen cup 1 into the sampling head 2, and when the second lifting driving mechanism 543 drives the piston rod 542 to descend, pushing the specimen in the sampling head 2 out of a lower port of the sampling head 2, thereby enabling the specimen to be coated on the slide 3. The output end of the first rotary driving mechanism 544 is in transmission connection with the syringe 541, and the first rotary driving mechanism 544 can drive the syringe 541 and the sampling head 2 sleeved on the syringe 541 to rotate, so that the rotation of the sampling head 2 is beneficial to uniformly coating the specimen on the slide 3.

It can be understood that the second lifting driving mechanism 543 is a first linear motor, and an output end of the first linear motor is connected to an upper end of the piston rod 542 through a floating joint. The first rotary driving mechanism 544 is a first hollow shaft motor, an output shaft of the first hollow shaft motor is connected with the upper end of the needle cylinder 541, the output shaft of the first hollow shaft motor drives the needle cylinder 541 to rotate, and the piston rod 542 penetrates through a center hole of the output shaft of the first hollow shaft motor.

Referring to fig. 5, in some embodiments, the sampling device 500 further includes a first horizontal linear driving mechanism 570 disposed on the rotating frame 111, the support frame 510 is connected to the rotating frame 111 through a first horizontal sliding mechanism 590, the sliding direction of the first horizontal sliding mechanism 590 passes through the rotation center of the rotating frame 111, the first horizontal sliding mechanism 590 functions to guide the moving direction of the support frame 510, the output end of the first horizontal linear driving mechanism 570 is connected to the support frame 510, and the first horizontal linear driving mechanism 570 drives the support frame 510 to move so as to separate the support frame 510 and the whole sampling device 500 from or near the rotating frame 111, and further to separate the sampling device 500 from or near the sampling head storage device 300/the specimen cup processing turntable 210/the slide storage device 400.

It is conceivable that the first horizontal sliding mechanism 590 includes a third slide rail and a third slider that are mutually matched, the third slide rail is horizontally disposed, a length direction of the third slide rail intersects with a rotation center of the rotation bracket 111, one of the third slide rail and the third slider is connected with the rotation bracket 111, and the other is connected with the support frame 510. The first horizontal linear driving mechanism 570 is a second linear motor, a housing of the second linear motor is connected to the rotating bracket 111, and an output shaft of the second linear motor is connected to the supporting frame 510.

It is conceivable that the rotating bracket 111 includes a column rotatably disposed on the table 110, and three horizontal support plates are disposed at the upper ends of the column, and the included angle between two adjacent support plates is 120 °, and the support frame 510 is connected to the support plates through a first horizontal sliding mechanism 590.

The stand column is tubular, and a pipe cavity of the stand column can be penetrated by cables connected with the first motor, the first linear motor, the first hollow shaft motor and the second linear motor.

Referring to fig. 1-3, in some embodiments of the specimen pretreatment system further comprises a sample head collection cassette 600, the sample head collection cassette 600 is connected with a collection tube 610, the collection tube 610 is disposed on the workbench 110, the collection tube 610 is disposed between the slide storage device 400 and the sample head storage device 300, the sample head 2 on the sample device 500 needs to be discarded when the sample head 2 on the sample device 500 has coated a specimen on the slide 3 during the process of transferring the sample device 500 from above the slide storage device 400 to above the sample head storage device 300, and the sample head 2 is removed from the sample device 500 when the sample head 2 on the sample device 500 is directly above the collection tube 610, and the sample head 2 drops into the collection tube 610.

It is known that the collecting box 600 is disposed below the workbench 110, the workbench 110 is provided with a through hole, the collecting pipe 610 vertically penetrates through the through hole and is connected with the workbench 110, and the collecting pipe 610 is communicated with the collecting box 600.

In some embodiments, the specimen cup processing apparatus 200 further includes a cap opening mechanism 220, a cap opening mechanism 230, and a cap closing mechanism 240, wherein the cap opening mechanism 220, the cap opening mechanism 230, and the cap closing mechanism 240 are sequentially disposed around the specimen cup processing turntable 210, the cap opening mechanism 220 is used for unscrewing the cap of the specimen cup 1, the cap opening mechanism 230 is used for opening and closing the cap on the specimen cup 1, and the cap closing mechanism 240 is used for screwing the cap.

When the specimen cup processing turntable 210 rotates with the specimen cup 1, the specimen cup processing turntable 210 rotates with the specimen cup 1 to a position corresponding to the cover opening mechanism 220, the cover opening mechanism 220 unscrews the cover of the specimen cup 1 so that the cover is placed on the cup body, then the specimen cup processing turntable 210 rotates with the specimen cup 1 to a position corresponding to the cover opening mechanism 230, the cover opening mechanism 230 lifts the cover on the cup body to expose the specimen in the cup body, and after the sampling device 500 takes the specimen from the cup body, the cover opening mechanism 230 places the lifted cover on the cup body, then the specimen cup processing turntable 210 rotates with the specimen cup 1 to a position corresponding to the cover closing mechanism 240, and the cover closing mechanism 240 tightens the cover on the cup body.

It is conceivable that the position corresponding to the cover lifting mechanism 230 is set as the extraction station, and the extraction station, the rotating bracket 111, and the collection pipe 610 are on the same line. When one of the sampling devices 500 is transferred to the position corresponding to the collection tube 610, the other two sampling devices 500 are not positioned at the position corresponding to the extraction station, so that the cover lifting mechanism 230 can lift the cup cover from the cup body or cover the cup body from the cup cover.

Referring to fig. 4, the cover opening mechanism 220 includes a first support 221, a fourth lifting driving mechanism 222, a second rotary driving mechanism 223, a first cover opening fastener 224 and a first cup fixing mechanism 225, where the first support 221 is disposed on the workbench 110 and beside the specimen cup processing turntable 210, the fourth lifting driving mechanism 222 is disposed on the first support 221, an output end of the fourth lifting driving mechanism 222 is rotatably connected with the first cover opening fastener 224, an output end of the second rotary driving mechanism 223 is in transmission connection with the first cover opening fastener 224, the first cover opening fastener 224 is disposed above the specimen cup processing turntable 210 and can be opposite to any specimen cup limiting groove 211, and the first cup fixing mechanism 225 is disposed on the first support 221 or the specimen cup processing turntable 210 or the workbench 110.

When the specimen cup processing turntable 210 carries the specimen cup 1 and transfers the specimen cup 1 to the corresponding cover opening mechanism 220, the first cover opening mechanism 225 fixes the position of the specimen cup 1, the fourth lifting driving mechanism 222 drives the first cover opening fastener 224 to descend, the first cover opening fastener 224 is buckled on the cup cover of the specimen cup 1 and locks the cup cover, then the second rotary driving mechanism 223 drives the first cover opening fastener 224 to rotate, and the first cover opening fastener 224 drives the cup cover to rotate, so that the cup cover is unscrewed.

The structure of the lid closing mechanism 240 is the same as or similar to that of the lid opening mechanism 220. The cover closing mechanism 240 comprises a second bracket, a fifth lifting driving mechanism, a third rotary driving mechanism, a second cover opening fastener and a second cup fixing mechanism, wherein the direction of the third rotary driving mechanism driving the second cover opening fastener to rotate is opposite to the direction of the second rotary driving mechanism 223 driving the first cover opening fastener 224 to rotate, and the third rotary driving mechanism drives the second cover opening fastener to rotate so as to screw the cup cover.

Referring to fig. 4, it is conceivable that the circumferential surface of the specimen cup processing turntable 210 is provided with notches at positions corresponding to the specimen cup limit grooves 211, and the notches are communicated with the specimen cup limit grooves 211. The first cup fixing mechanism 225 comprises a second horizontal linear driving mechanism and a pressing block arranged at the output end of the second horizontal linear driving mechanism, the direction in which the pressing block is driven by the second horizontal linear driving mechanism is intersected with the rotation center of the specimen cup processing turntable 210 and is mutually perpendicular, the pressing block enters the specimen cup limiting groove 211 through a notch, so that the cup body of the specimen cup 1 in the specimen cup limiting groove 211 is tightly propped against the inner wall of the specimen cup limiting groove 211, the rotation of the cup body of the specimen cup 1 is locked, and when the cup cover is driven by the first cover opening fastener 224 to rotate, the cup body does not rotate, and the cup cover is unscrewed.

The fifth lifting driving mechanism is also a screw pair mechanism, the third rotary driving mechanism is a second hollow shaft motor, and the second horizontal linear driving mechanism is a third linear motor.

The second cup-fixing mechanism is configured and arranged in the same or similar manner as the first cup-fixing mechanism 225.

Referring to fig. 4 and 6, in some embodiments, the cover lifting mechanism 230 includes a fourth rotary driving mechanism 231, a swinging member 232, an L-shaped rod 233 and a suction cup 234, where the fourth rotary driving mechanism 231 is disposed on the workbench 110, the swinging member 232 is rotatably disposed on the workbench 110 and is in transmission connection with an output end of the fourth rotary driving mechanism 231, the swinging member 232 is connected with one end of the L-shaped rod 233, the other end of the L-shaped rod 233 is connected with the suction cup 234, the fourth rotary driving mechanism 231 drives the swinging member 232 to rotate, and the swinging member 232 drives the L-shaped rod 233 to swing, so that the other end of the L-shaped rod 233 carries the suction cup 234 to realize downward buckling and upward lifting, and the suction cup 234 is ensured to drive the cup cover in an up-down direction.

The fourth rotation driving mechanism 231 is a second motor, the output end of the second motor is provided with a first gear, the swinging member 232 is a second gear, and the first gear and the second gear are meshed with each other.

The specimen cup processing turntable 210 is annular, the rotation center of the specimen cup processing turntable 210 is vertically arranged, the L-shaped rod 233 penetrates through the center hole of the specimen cup processing turntable 210, and the fourth rotary driving mechanism 231 is arranged below the specimen cup processing turntable 210.

Referring to fig. 1 and 4, the specimen pretreatment system further includes a specimen cup position adjustment device 700, the specimen cup position adjustment device 700 is disposed beside the specimen cup processing turntable 210, and the specimen cup position adjustment device 700 is used for driving the specimen cup 1 on the specimen cup processing turntable 210 to rotate.

The inner wall of the specimen cup limit groove 211 is provided with a plurality of rotatable rotating wheels, the rotating center of the rotating wheels is vertically arranged, and the outer circle surface of the rotating wheels can be propped against the outer wall of the specimen cup 1.

Referring to fig. 4, the specimen cup position adjusting device 700 includes a third horizontal linear driving mechanism 710, a fifth rotary driving mechanism 720, a rotary pressing ring 730 and a first sliding plate 740, where the first sliding plate 740 is connected with the workbench 110 through a second horizontal sliding mechanism, the guiding direction of the second horizontal sliding mechanism intersects with the rotation center of the specimen cup processing turntable 210 and is perpendicular to each other, the third horizontal linear driving mechanism 710 is connected with the workbench 110, the output end of the third horizontal linear driving mechanism 710 is connected with the first sliding plate 740, the fifth rotary driving mechanism 720 is disposed on the first sliding plate 740, the output end of the fifth rotary driving mechanism 720 is in transmission connection with the rotary pressing ring 730, the rotation center of the rotary pressing ring 730 is vertically disposed, the third horizontal linear driving mechanism 710 drives the first sliding plate 740 to move toward the specimen cup processing turntable 210 or away from the specimen cup processing turntable 210, so that the rotary pressing ring 730 abuts against the specimen cup 1, the fifth rotary driving mechanism 720 drives the specimen cup 1 to rotate in the cup limiting groove 211, and adjusts the position of the specimen cup 1, so that the specimen device 500 is convenient for extracting the specimen.

The third horizontal linear driving mechanism 710 is a fourth linear motor, and the fifth rotary driving mechanism 720 is a third motor. The structure of the second horizontal sliding mechanism is the same as that of the first horizontal sliding mechanism.

Referring to fig. 3, in some embodiments, the specimen pretreatment system further includes a specimen cup loading device 800, where the specimen cup loading device 800 is disposed on the workbench 110 and beside the specimen cup processing turntable 210, and the specimen cup loading device 800 is used to transfer the specimen cup 1 to the specimen cup limit slot 211 and remove the specimen cup 1 from the specimen cup limit slot 211 after the specimen has been removed.

It is conceivable that the specimen cup feeding device 800 includes a fourth horizontal linear driving mechanism 810, a fifth horizontal linear driving mechanism 820, a sixth elevating driving mechanism 830, and a suction nozzle 840, the driving directions of the fourth horizontal linear driving mechanism 810 and the fifth horizontal linear driving mechanism 820 are perpendicular to each other and are both horizontal directions, the fourth horizontal linear driving mechanism 810 and the fifth horizontal linear driving mechanism 820 are for driving the suction nozzle 840 to move in the horizontal direction, and the sixth elevating driving mechanism 830 drives the suction nozzle 840 to perform elevating movement.

The specimen cup feeding device 800 further comprises a sixth horizontal linear driving mechanism, a third horizontal sliding mechanism and a tray 850, wherein a plurality of specimen cup storage grooves 851 are formed in the tray 850, the specimen cup storage grooves 851 are used for temporarily storing the specimen cups 1, the tray 850 is connected with the workbench 110 through the third horizontal sliding mechanism, the output end of the sixth horizontal linear driving mechanism is connected with the tray 850, the sixth horizontal linear driving mechanism drives the tray 850 to move on the workbench 110, so that the position of the tray 850 is adjusted, the suction nozzle 840 is convenient for adsorbing and transferring the specimen cups 1 on the tray 850 to the specimen cup limiting grooves 211 of the specimen cup processing turntable 210, and adsorbing and transferring the specimen cups 1 in the specimen cup limiting grooves 211 to the specimen cup storage grooves 851.

The fourth horizontal linear driving mechanism 810, the fifth horizontal linear driving mechanism 820, the sixth elevating driving mechanism 830, and the sixth horizontal linear driving mechanism may be screw pair mechanisms. The suction nozzle 840 is connected with a negative pressure mechanism through an air pipe.

Referring to fig. 7, in some embodiments, the sampling head storage device 300 includes a seventh horizontal linear driving mechanism 320, a sixth rotary driving mechanism 330 and a sampling head turntable 340, the seventh horizontal linear driving mechanism 320 is disposed on the workbench 110, an output end of the seventh horizontal linear driving mechanism 320 is connected with the sixth rotary driving mechanism 330, an output end of the sixth rotary driving mechanism 330 is disposed upwards and is in transmission connection with the sampling head turntable 340, the sampling head limiting slot 310 is disposed on the sampling head turntable 340, the seventh horizontal linear driving mechanism 320 drives the sixth rotary driving mechanism 330 and the sampling head turntable 340 to move on the workbench 110, and the sixth rotary driving mechanism 330 drives the sampling head turntable 340 to rotate, thereby realizing adjustment of the position of the sampling head limiting slot 310, facilitating placement of the sampling heads 2 in the sampling head limiting slots 310, and facilitating removal of the respective sampling heads 2 on the sampling head turntable 340 one by the sampling device 500.

The sampling head storage device 300 further comprises a second sliding plate, the second sliding plate is arranged on the workbench 110 through a fourth horizontal sliding mechanism, the sixth rotary driving mechanism 330 is arranged on the second sliding plate, and the sampling head turntable 340 is rotatably arranged on the second sliding plate.

The seventh horizontal linear driving mechanism 320 includes a fourth motor, a driving pulley, a driven pulley, and a belt, the fourth motor is connected with the table 110, an output end of the fourth motor is in driving connection with the driving pulley, the driven pulley is rotatably connected with the table 110, the belt is wound around the driving pulley and the driven pulley, and the belt is connected with the second slip plate. The fourth motor drives the driving belt pulley to rotate, so that the driving belt is driven to rotate, and the belt drives the second sliding plate to move. The sixth rotary driving mechanism 330 is a fifth motor, and an output shaft of the fifth motor is in transmission connection with the sampling head turntable 340.

The rotary support 111 is connected with a seventh rotary driving mechanism, which is a sixth motor, and the sixth motor is connected with the workbench 110 and drives the rotary support 111 to rotate. An eighth rotary drive mechanism is connected to the specimen cup processing turntable 210. The eighth rotary driving mechanism is a seventh motor, the seventh motor is connected with the workbench 110, and the seventh motor drives the specimen cup processing turntable 210 to rotate.

The frame 100 is connected with a sealing shell, and the sealing shell is covered on the workbench 110, so that the frame 100, the specimen cup processing device 200, the sampling head storage device 300, the slide storage device 400, the three sampling devices 500, the sampling head collecting box 600, the specimen cup position adjusting device 700 and the specimen cup feeding device 800 are sealed on the frame 100. The sealing shell is provided with a bin gate, when the bin gate is opened, the sample cup 1 carrying a new sample and the sample cup 1 from which the sample has been taken on the taking tray 850 can be put into the sample cup accommodating groove 851, the slide 3 can be put into the slide storage device 400, and the sampling head 2 can be put into the sampling head limiting groove 310.

The technical features of the above embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.

Of course, the present application is not limited to the above-described embodiments, and those skilled in the art can make equivalent modifications or substitutions without departing from the spirit of the present application, and these equivalent modifications or substitutions are included in the scope of the present application as defined in the appended claims.

Claims (5)

1. A specimen pretreatment system, comprising:

the machine frame is provided with a workbench, and a rotary bracket is arranged on the workbench;

The specimen cup processing device comprises a specimen cup processing rotary table rotatably arranged on the workbench, wherein a plurality of specimen cup limiting grooves which are annularly distributed are formed in the specimen cup processing rotary table and are used for limiting specimen cups;

the sampling head storage device is arranged on the workbench and is provided with a plurality of sampling head limiting grooves used for limiting the sampling heads;

the slide storage device is arranged on the workbench and is provided with a plurality of slide limiting grooves which are used for limiting slides;

The triple sampling device comprises three sampling devices, wherein the sampling head storage devices, the sample cup processing turnplate and the slide storage devices are sequentially arranged around the rotating support, three sampling devices are respectively arranged on the rotating support in a lifting manner, three sampling devices are distributed in a triangular mode around the rotating center of the rotating support, the included angle between every two adjacent sampling devices and the rotating center of the rotating support is 120 degrees, the rotating support drives the three sampling devices to rotate above the sampling head storage devices, the sample cup processing turnplate and the slide storage devices, and the three sampling devices can sequentially sleeve the sampling heads on the sampling head limiting grooves, extract samples on the sample cups through the sampling heads, coat the samples on the sampling heads on the slides and discard the sampling heads;

The sampling device comprises a supporting frame, a first lifting driving mechanism, a lifting frame and an injection mechanism, wherein the rotating bracket comprises an upright post which is rotatably arranged on a workbench, three horizontal supporting plates are arranged at the upper end of the upright post, the included angle between every two adjacent supporting plates is 120 degrees, the supporting frame is connected with the supporting plates, the rotating bracket supports the supporting frame and drives the supporting frame to rotate, the lifting frame is connected with the supporting frame through a first vertical sliding mechanism, the first lifting driving mechanism is arranged on the supporting frame, the output end of the first lifting driving mechanism is connected with the lifting frame, the injection mechanism is arranged on the lifting frame, the injection mechanism comprises a needle cylinder connected with the lifting frame, and the lower end of the needle cylinder can be inserted into the upper port of the sampling head to be sleeved with the sampling head;

The sampling device further comprises a blanking plate and an elastic piece, the blanking plate is connected with the supporting frame through a second vertical sliding mechanism, so that the blanking plate can move up and down on the supporting frame, one end of the blanking plate is provided with a U-shaped groove, one end of the blanking plate is sleeved on the needle cylinder through the U-shaped groove, two ends of the elastic piece are respectively connected with the supporting frame and the blanking plate, the blanking plate is in floating connection with the supporting frame, when the elastic piece is in a natural state, the blanking plate is in an initial position, one end of the blanking plate can prop against the upper end face of the sampling head to fade down the sampling head from the needle cylinder, the second vertical sliding mechanism comprises a second sliding rail and a second sliding block which are matched with each other, the second sliding rail is vertically arranged on the supporting frame and beside the lifting frame, the second sliding block is connected with the other end of the blanking plate through the side plate, and the blanking plate is horizontally arranged;

The working process of the sampling device is as follows: when the sampling device needs to take the sampling head, the first lifting driving mechanism drives the lifting frame and the needle cylinder to descend, the lifting frame is propped against the blanking plate and drives the blanking plate to descend, the elastic piece is stretched until the lower end of the needle cylinder is inserted into the upper port of the sampling head, then the lifting frame and the needle cylinder are driven by the first lifting driving mechanism to ascend, the needle cylinder lifts the sampling head, the lifting frame does not lower the blanking plate any more, and at the moment, the elastic piece is restored to be in an original state, and then the blanking plate is lifted to the initial position; when the sampling device needs to discard the sampling head, the first lifting driving mechanism drives the lifting frame and the needle cylinder to ascend, the needle cylinder carries the sampling head to ascend, so that the upper end face of the sampling head abuts against the lower surface of the blanking plate, the blanking plate is not greatly ascended after being in an initial position, the needle cylinder and the sampling head ascend relative to the blanking plate, and the blanking plate fades the sampling head from the needle cylinder;

The injection mechanism further comprises a piston rod, a second lifting driving mechanism and a first rotary driving mechanism, wherein the second lifting driving mechanism and the first rotary driving mechanism are arranged on the lifting frame, the second lifting driving mechanism and the first rotary driving mechanism synchronously lift along with the lifting frame and the needle cylinder, the output end of the second lifting driving mechanism is connected with the upper end of the piston rod, the lower end of the piston rod is matched with the needle cylinder, the output end of the first rotary driving mechanism is in transmission connection with the needle cylinder, the first rotary driving mechanism is a first hollow shaft motor, the output shaft of the first hollow shaft motor is connected with the upper end of the needle cylinder, the output shaft of the first hollow shaft motor drives the needle cylinder to rotate, and the piston rod penetrates through the central hole of the output shaft of the first hollow shaft motor; when the second lifting driving mechanism drives the piston rod to ascend, negative pressure is formed in the needle cylinder and the sampling head, so that a sample in the sample cup is sucked into the sampling head, and when the second lifting driving mechanism drives the piston rod to descend, the sample in the sampling head is pushed out of a lower port of the sampling head, so that the sample is coated on a slide, the first rotary driving mechanism can drive the needle cylinder and the sampling head sleeved on the needle cylinder to rotate, and the rotation of the sampling head is favorable for uniformly coating the sample on the slide;

The sample cup processing device further comprises a sampling head collecting box, wherein the sampling head collecting box is connected with a collecting pipe, the collecting pipe is arranged on the workbench, and the collecting pipe is positioned between the slide storage device and the sampling head storage device; the specimen cup processing device further comprises a cover opening mechanism, a cover lifting mechanism and a cover closing mechanism, wherein the cover opening mechanism, the cover lifting mechanism and the cover closing mechanism are sequentially arranged around the specimen cup processing turntable, the cover opening mechanism is used for unscrewing a cup cover of the specimen cup, the cover lifting mechanism is used for lifting and closing the cup cover on the specimen cup, the cover closing mechanism is used for screwing the cup cover, the position corresponding to the cover lifting mechanism is set to be an extraction station, the rotating support and the collecting pipe are located on the same straight line, and when one sampling device is transferred to the position corresponding to the collecting pipe, the other two sampling devices are not located at positions corresponding to the extraction station, so that the cover lifting mechanism is convenient to lift the cup cover from the cup body or cover the cup cover on the cup body.

2. A specimen pretreatment system according to claim 1, wherein: the sampling device further comprises a first horizontal linear driving mechanism arranged on the rotary support, the support frame is connected with the rotary support through a first horizontal sliding mechanism, the sliding direction of the first horizontal sliding mechanism penetrates through the rotary center of the rotary support, and the output end of the first horizontal linear driving mechanism is connected with the support frame.

3. A specimen pretreatment system according to claim 1, wherein: the lifting mechanism comprises a fourth rotary driving mechanism, a swinging piece, an L-shaped rod and a sucker, wherein the fourth rotary driving mechanism is arranged on the workbench, the swinging piece is rotatably arranged on the workbench and is in transmission connection with the output end of the fourth rotary driving mechanism, the swinging piece is connected with one end of the L-shaped rod, and the other end of the L-shaped rod is connected with the sucker.

4. A specimen pretreatment system according to claim 1, wherein: still include sample cup loading attachment, sample cup loading attachment locates on the workstation and be in by sample cup processing carousel, sample cup loading attachment is used for with sample cup transfer to sample cup spacing groove and follow sample cup spacing groove is gone up and is taken down the sample cup that has been taken the sample.

5. A specimen pretreatment system according to claim 1, wherein: the sampling head storage device comprises a seventh horizontal linear driving mechanism, a sixth rotary driving mechanism and a sampling head turntable, wherein the seventh horizontal linear driving mechanism is arranged on the workbench, the output end of the seventh horizontal linear driving mechanism is connected with the sixth rotary driving mechanism, the output end of the sixth rotary driving mechanism is upwards arranged and is in transmission connection with the sampling head turntable, and the sampling head limiting groove is formed in the sampling head turntable.