CN117687461B - Environment regulation and control system of animal laboratory - Google Patents
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Abstract
The invention discloses an environment regulation and control system of an animal laboratory, which relates to the technical field of monitoring and control of laboratory environment, and comprises an environment signal acquisition module: respectively acquiring environmental parameter information of an animal laboratory through a sensor group and an electromagnetic radiation instrument, and counting measurement results changing along with time to generate dynamic data related to time; and a data processing module: receiving dynamic data transmitted by an environment signal acquisition module, and carrying out correction optimization calculation on the dynamic data by adopting a data correction algorithm to obtain dynamic correction data; according to the invention, through correcting and optimizing the dynamic data collected by the animal laboratory, the interference of communication and data transmission between the sensor and the processing controller equipment in the laboratory caused by electromagnetic radiation and magnetic field changes is avoided, the accuracy of environment monitoring data is improved, a linear fitting model is established, and the functions of accurately evaluating and regulating strategies of the laboratory environment are realized.
Description
Technical Field
The invention relates to the technical field of laboratory environment monitoring and control, in particular to an environment regulation and control system of an animal laboratory.
Background
The animal laboratory is a building suitable for raising and breeding experimental animals, and has specific environmental requirements and experimental means so as to ensure the quality of the animals and the accuracy and reliability of experimental study. In general, animal laboratories consider to be far away from noise, pollution sources, ventilation and greening isolation in site selection, so that the building is constructed in places with clean and quiet environment, high topography, good drainage and ventilation and guaranteed water and electricity supply. The environmental regulation and control system of the animal laboratory generally comprises an environmental information acquisition module, an environmental monitoring module, an environmental regulation module and an alarm module, but only monitors the environmental information of the temperature, the humidity, the gas concentration, the illumination intensity and the noise level in the laboratory at present, and the magnetic field signals of the operation of the laboratory electrical equipment can have abnormal fluctuation signals to influence the environmental data, which can lead to the inaccuracy of the environmental monitoring data and influence the evaluation and regulation strategy of the laboratory environment.
For example, in the application number CN201910007296.2, an intelligent environmental condition monitoring system is disclosed, environmental parameters of an environment where a laboratory is located are collected through an information collecting module, the environmental monitoring module judges whether the environment where the laboratory is located meets standards according to the collected environmental parameters and a preset environmental parameter interval, and when the environment where the laboratory is located does not meet standards, an environmental regulating module regulates the environmental parameters of the environment where the laboratory is located into the preset environmental parameter interval for effectively integrating the existing environmental parameter monitoring, so that the safety of the experimental process and the accuracy of the result are improved, but the behavior and vital sign disorder of experimental animals also affect the environment of the laboratory, and the defect of error or deviation of laboratory regulation strategy exists.
The prior art has the following defects: in an environment regulation system of an animal laboratory, because experimental electrical equipment or instruments such as a centrifugal machine, an oscillator and the like in the laboratory can generate a magnetic field in the working operation, electromagnetic radiation is caused, the problems of damage to a nervous system, poor immune system, behavior change, genital organ change and the like of the experimental animal are possibly caused, and the physical characteristics of the experimental animal change, the stability and the accuracy of monitoring data of the laboratory environment are generated, so that threshold regulation measures are adopted for the environment monitoring data, the life safety of the experimental animal is greatly threatened, and the problem of environmental pollution is caused; and high intensity electromagnetic radiation and magnetic field variations can interfere with communications and data transmission between sensors and process controller equipment in the laboratory, thereby causing the sensors to be unable to accurately sense environmental parameters, data transmission errors or losses, and thereby affecting control and monitoring functions of the system.
The above information disclosed in the background section is only for enhancement of understanding of the background of the disclosure and therefore it may include information that does not form the prior art that is already known to a person of ordinary skill in the art.
Disclosure of Invention
The invention aims to provide an environment regulation and control system of an animal laboratory, which is characterized in that dynamic data collected by the animal laboratory are corrected and optimized, a linear fitting model is built, a relevant influence coefficient is obtained according to the influence degree of electromagnetic radiation on temperature, humidity, gas particulate matter concentration, illumination intensity, frequency and noise level, and then data comprehensive analysis is carried out, so that an environment parameter strategy is accurately regulated and controlled to regulate the stability of the laboratory environment system, and the problems in the background technology are solved.
In order to achieve the above object, the present invention provides the following technical solutions: an environmental regulation and control system of animal laboratory includes environmental signal acquisition module: respectively acquiring environmental parameter information of an animal laboratory through a sensor group and an electromagnetic radiation instrument, and counting measurement results changing along with time to generate dynamic data related to time;
and a data processing module: receiving dynamic data transmitted by an environment signal acquisition module, carrying out correction optimization calculation on the dynamic data by adopting a data correction algorithm to obtain dynamic correction data, then establishing a linear fitting model according to the correction data, fitting the dynamic correction data to a linear relation to obtain prediction result data and actual influence data, and carrying out contrast analysis to solve the linear fitting model to obtain an associated influence coefficient of environment parameters;
And the data comprehensive analysis module: the method comprises the steps of establishing a comprehensive analysis model after collecting the environmental parameter data actually collected during the operation of a follow-up animal laboratory through obtaining the associated influence coefficient of the environmental parameter calculated in the data processing module, generating an early warning regulation signal, and transmitting the early warning regulation signal to an evaluation regulation module for evaluation calculation;
and (3) evaluating a regulation module: receiving an early warning regulation signal of the data comprehensive analysis module, evaluating according to a threshold range of a preset environmental parameter signal, regulating the environmental parameter data to a preset threshold by adopting a regulation strategy, and transmitting an evaluation result and regulation measures to an interface warning interaction module for human-computer interaction;
Interface warning interaction module: and receiving data and instructions of the system on environmental parameters in the animal laboratory from each module, providing warning, reporting and operating interfaces for staff, and controlling and monitoring the state and operation of the system in real time by an interactive mode and triggering an alarm mechanism.
Preferably, the sensor group comprises a temperature sensor, a humidity sensor, a gas sensor, an illuminance sensor and a sound sensor, and is used for monitoring and collecting parameter data signals of temperature, humidity, gas particulate matter concentration, illumination intensity, frequency and noise level in an animal laboratory in real time, and the parameter data signals are respectively calibrated as、/>、/>、/>、/>；
The electromagnetic radiation instrument is used for measuring radiation intensity data of electromagnetic field in animal laboratory, i.e. collecting electromagnetic radiation data of environmental parameter signal in animal laboratory, and is calibrated as；
The environmental parameter signal includes temperatureHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Is a data signal of (a);
the time change is measured by taking twenty-four hours a day as a period, sixty minutes a hour, respectively in each minute time interval Average value/>, of internal recording laboratory environmental parameter signalsMaximum/>And minimum valueDiscrete point data signals of (a);
Dynamic data is recorded in real time over time The change data of each environmental parameter signal in the changed animal laboratory is marked as/>Dynamic data/>And/>，，/>In the/>Expressed as time/>Function of varying environmental parameter signals, i.e. discrete time series,/>Expressed as time/>Average value of the varying environmental parameter signal,/>Expressed as time/>Maximum value of the varying environmental parameter signal,/>Expressed as time/>Minimum value of the varying environmental parameter signal,/>Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Average taken at change,/>Expressed as/>Average value in time interval; /(I)Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Maximum value taken during change,/>Expressed as/>The maximum value in the time interval is set,Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Minimum value taken during change,/>Expressed as/>Minimum value within the time interval.
Preferably, the logic of the data correction algorithm is as follows:
Environmental parameter signals obtained according to real-time monitoring in animal laboratories over time Mean value of the change/>Maximum/>And minimum/>Dynamic data/>Establishing a time sequence analysis prediction model and using the current timeAs input, the current time/>, is predictedEnvironmental parameter value of point/>And then the current time/>Real environmental parameter values/>, acquired in real time by pointsPerforming difference calculation to obtain correction factors, and calibrating as/>According to correction factor/>Carrying out correction optimization on the time sequence analysis prediction model, and carrying out next calculation by taking the corrected prediction value as new dynamic data;
The time sequence analysis prediction model is used for correcting data acquired by a sensor group and an electromagnetic radiometer in real time, is used for improving the monitoring acquisition precision of the sensor group and the electromagnetic radiometer and reducing the data transmission error, adopts an ARMA-like algorithm, and has a calculation formula of In the above, the ratio of/>Expressed as a constant,/>Expressed as/>Random error term of time instant,/>Expressed as/>Time series data of time instant,/>Expressed as time/>Average value of the varying environmental parameter signal,/>Expressed as time/>Maximum value of the varying environmental parameter signal,/>Expressed as time/>Minimum value of the varying environmental parameter signal,/>Represented as averages of laboratory environmental parameter signals in a time series analysis prediction model, respectivelyParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term; /(I)Expressed as maximum value/>, respectively, of laboratory environmental parameter signals in a time series analysis prediction modelParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term; /(I)Expressed as the minimum value/>, respectively, of laboratory environmental parameter signals in a time series analysis prediction modelParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term;
Comparing the predicted value calculated by the time sequence analysis prediction model with the actual observed value, and calculating a predicted error to obtain a correction factor I.e./>In/>For correction factor, dynamic data/>, is brought inObtaining dynamic data/>, of the environmental parameter values after correction and optimizationAnd/>。
Preferably, the step of linearly fitting the model is as follows:
Using modified dynamic data According to big data analysis, each parameter in the environmental parameter signal is known to be in time/>The maximum value in the interior affects the most, and electromagnetic radiation/>For temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Has an influence on the ambient parameter signal and therefore adopts the maximum value of the modified dynamic dataIn the above, the temperatureHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Establishing a linear fitting model, and judging electromagnetic radiation/>And temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>The relationship between them;
The linear regression algorithm is adopted, and the calculation formula is In the above, the ratio of/>Expressed as the intercept in a linear fitting model, and/>Expressed as temperature/>, respectively, in a linear fitting modelHumidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Weight coefficient of parameter,/>Expressed as electromagnetic radiation/>And temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Random error terms between.
Preferably, the logic for obtaining the association influence coefficient is as follows:
Electromagnetic radiation fitted according to a linear regression algorithm And temperature/>Humidity/>Concentration of gas particulate matterLight intensity and frequency/>And noise level/>The linear relation is obtained by adopting a least square method, and the correlation influence coefficient is calibrated as/>The calculation formula is/>In the above, the ratio of/>Represents a summation calculation, and/>，/>Expressed as a natural number of 1-5,Expressed as temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Respectively with electromagnetic radiation/>Is a sum of squares of the residuals of the (c) signal,Independent variable matrix,/>Is a dependent variable vector,/>Expressed as a transpose of the argument matrix,/>Represented as the inverse of the argument matrix.
Preferably, the data comprehensive analysis model is dynamic data of relevant environmental parameters in an animal laboratory, which are obtained after being processed by the data processing moduleCombining the correlation influence coefficient/>, obtained in the linear fitting modelTo determine the influence degree of electromagnetic field generated by the electrical equipment of animal laboratory in the running state on the laboratory environment parameters, namely generating an early warning regulation signal, and calibrating as/>The calculation formula is/>In the above, the ratio of/>Represented as the sum of dynamic data of modified optimized environmental parameter values, i.e。
Preferably, the evaluation logic of the early warning regulation signal is as follows:
According to the early warning regulation and control signal The deviation degree is compared with a preset threshold value of the environmental parameter signal, and then the early warning grade corresponding to different deviation degrees is determined;
According to the early warning grade corresponding to the early warning regulation signal, the laboratory manager and related personnel are informed of abnormal conditions in the form of sound, light signals and text prompt, and the numerical value of each environmental parameter in the laboratory is regulated and controlled, namely corresponding regulation measures are taken.
Preferably, the content of the threshold range of the preset environmental parameter signal is as follows:
temperature in environmental parameter signals in animal laboratory The threshold range of (2) is/>In which, in the process,Expressed as minimum and maximum values of adjustable temperature constants in animal laboratory that do not affect vital signs and neurological states of experimental animals,/>Expressed as open interval, i.e. temperature/>The value range of (2) is/>Between, but does not include/>And/>Is a self-contained feature of (a).
Preferably, the regulation and control measure is that the environmental regulation and control system of the animal laboratory comprises equipment of a fresh air conditioner, an intelligent humidifier, an intelligent control lamp, a silencer and a demagnetizer, the threshold value of a preset environmental parameter signal is compared and evaluated by evaluating an early warning regulation and control signal generated by the prediction of dynamic data and associated influence coefficients in a regulation and control module, and the regulation and control module can accurately regulate and control temperature, humidity, gas particle concentration, illumination intensity and frequency, noise and electromagnetic radiation.
Preferably, the environmental control method of the animal laboratory is as follows;
a sensor group and an electromagnetic radiation instrument are adopted to monitor environmental parameter signals of an animal laboratory in real time, and discrete data variables are counted along with time change to generate dynamic data related to time;
Carrying out correction optimization processing on the dynamic data to obtain predicted dynamic data, carrying out linear fitting on environmental parameter semaphores, and obtaining associated influence coefficients after comparing calculation with actual data;
according to the associated influence coefficient, a comprehensive analysis model is established, and an early warning regulation signal is generated;
And comparing and evaluating a threshold value of a preset environmental parameter signal according to the early warning regulation signal, accurately regulating and controlling the environmental parameter of the laboratory, and interacting with a human-computer interface to monitor the environmental state of the laboratory in real time.
In the technical scheme, the invention has the technical effects and advantages that:
according to the invention, through correcting and optimizing the dynamic data collected by the animal laboratory, the interference between communication and data transmission between the sensor and the processing controller equipment in the laboratory caused by electromagnetic radiation and magnetic field change is avoided, and the accuracy of environment monitoring data is improved;
The linear fitting model is built, the influence degree of electromagnetic radiation on temperature, humidity, gas particulate matter concentration, illumination intensity, frequency and noise level is obtained, namely, a correlation influence coefficient is generated, the stirring change of magnetic field signals and environmental parameters generated in the operation process of electrical equipment in an animal laboratory is found, the functions of accurate assessment and regulation strategy of the laboratory environment are realized, and the accuracy and stability of the environment of the control animal laboratory are further improved;
And the comprehensive data analysis is carried out through the data comprehensive analysis module, an early warning regulation signal is generated, and the early warning regulation signal is evaluated with a threshold range of a preset environmental parameter signal so as to adopt a corresponding regulation strategy, and then workers are reminded in a warning interaction mode, so that the control and monitoring functions of the environmental regulation of the animal laboratory are enhanced.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments described in the present application, and other drawings may be obtained according to these drawings for those skilled in the art.
FIG. 1 is a block diagram of an environmental control system of an animal laboratory of the present invention.
FIG. 2 is a flow chart of the environmental control method in the animal laboratory of the present invention.
Detailed Description
Example embodiments will now be described more fully with reference to the accompanying drawings. However, the exemplary embodiments may be embodied in many forms and should not be construed as limited to the examples set forth herein; rather, these example embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the concept of the example embodiments to those skilled in the art.
Example 1
As shown in fig. 1, the invention provides an environment regulation system of an animal laboratory, which comprises an environment signal acquisition module: respectively acquiring environmental parameter information of an animal laboratory through a sensor group and an electromagnetic radiation instrument, and counting measurement results changing along with time to generate dynamic data related to time;
The sensor group comprises a temperature sensor, a humidity sensor, a gas sensor, an illuminance sensor and a sound sensor, and is used for monitoring and collecting parameter data signals of temperature, humidity, gas particulate matter concentration, illumination intensity, frequency and noise level in an animal laboratory in real time, and the parameter data signals are respectively calibrated as follows 、/>、/>、/>、/>；
The electromagnetic radiation instrument is used for measuring radiation intensity data of electromagnetic field in animal laboratory, i.e. collecting electromagnetic radiation data of environmental parameter signal in animal laboratory, and is calibrated as；
The environmental parameter signal includes temperatureHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Is a data signal of (a).
The time change is measured by taking twenty-four hours a day as a period, sixty minutes a hour, respectively in each minute time intervalAverage value/>, of internal recording laboratory environmental parameter signalsMaximum/>And minimum valueDiscrete point data signals of (a);
Dynamic data is recorded in real time over time The change data of each environmental parameter signal in the changed animal laboratory is marked as/>Dynamic data/>And/>，，/>In the/>Expressed as time/>Function of varying environmental parameter signals, i.e. discrete time series,/>Expressed as time/>Average value of the varying environmental parameter signal,/>Expressed as time/>Maximum value of the varying environmental parameter signal,/>Expressed as time/>Minimum value of the varying environmental parameter signal,/>Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Average taken at change,/>Expressed as/>Average value in time interval; /(I)Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Maximum value taken during change,/>Expressed as/>The maximum value in the time interval is set,Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Minimum value taken during change,/>Expressed as/>Minimum value within the time interval.
And a data processing module: receiving dynamic data transmitted by an environment signal acquisition module, carrying out correction optimization calculation on the dynamic data by adopting a data correction algorithm to obtain dynamic correction data, then establishing a linear fitting model according to the correction data, fitting the dynamic correction data to a linear relation to obtain prediction result data and actual influence data, and carrying out contrast analysis to solve the linear fitting model to obtain an associated influence coefficient of environment parameters;
The logic of the data correction algorithm is as follows:
Environmental parameter signals obtained according to real-time monitoring in animal laboratories over time Mean value of the change/>Maximum/>And minimum/>Dynamic data/>Establishing a time sequence analysis prediction model and using the current timeAs input, the current time/>, is predictedEnvironmental parameter value of point/>And then the current time/>Real environmental parameter values/>, acquired in real time by pointsPerforming difference calculation to obtain correction factors, and calibrating as/>According to correction factor/>Carrying out correction optimization on the time sequence analysis prediction model, and carrying out next calculation by taking the corrected prediction value as new dynamic data;
The time sequence analysis prediction model is used for correcting data acquired by a sensor group and an electromagnetic radiometer in real time, is used for improving the monitoring acquisition precision of the sensor group and the electromagnetic radiometer and reducing the data transmission error, adopts an ARMA-like algorithm, and has a calculation formula of In the above, the ratio of/>Expressed as a constant,/>Expressed as/>Random error term of time instant,/>Expressed as/>Time series data of time instant,/>Expressed as time/>Average value of the varying environmental parameter signal,/>Expressed as time/>Maximum value of the varying environmental parameter signal,/>Expressed as time/>Minimum value of the varying environmental parameter signal,/>Represented as averages of laboratory environmental parameter signals in a time series analysis prediction model, respectivelyParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term; /(I)Expressed as maximum value/>, respectively, of laboratory environmental parameter signals in a time series analysis prediction modelParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term; /(I)Expressed as the minimum value/>, respectively, of laboratory environmental parameter signals in a time series analysis prediction modelParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term;
Comparing the predicted value calculated by the time sequence analysis prediction model with the actual observed value, and calculating a predicted error to obtain a correction factor I.e./>In/>For correction factor, dynamic data/>, is brought inObtaining dynamic data/>, of the environmental parameter values after correction and optimizationAnd/>。
It should be noted that the steps of the linear fitting model are as follows:
Using modified dynamic data According to big data analysis, each parameter in the environmental parameter signal is known to be in time/>The maximum value in the interior affects the most, and electromagnetic radiation/>For temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Has an influence on the ambient parameter signal and therefore adopts the maximum value of the modified dynamic dataIn the above, the temperatureHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Establishing a linear fitting model, and judging electromagnetic radiation/>And temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>The relationship between them;
The linear regression algorithm is adopted, and the calculation formula is In the above, the ratio of/>Expressed as the intercept in a linear fitting model, and/>Expressed as temperature/>, respectively, in a linear fitting modelHumidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Weight coefficient of parameter,/>Expressed as electromagnetic radiation/>And temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Random error terms between.
It should be noted that, the logic for acquiring the association influence coefficient is as follows:
Electromagnetic radiation fitted according to a linear regression algorithm And temperature/>Humidity/>Concentration of gas particulate matterLight intensity and frequency/>And noise level/>The linear relation is obtained by adopting a least square method, and the correlation influence coefficient is calibrated as/>The calculation formula is/>In the above, the ratio of/>Represents a summation calculation, and/>，/>Expressed as a natural number of 1-5,Expressed as temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>And noise level/>Respectively with electromagnetic radiation/>Is a sum of squares of the residuals of the (c) signal,Independent variable matrix,/>Is a dependent variable vector,/>Expressed as a transpose of the argument matrix,/>Represented as the inverse of the argument matrix.
And the data comprehensive analysis module: the method comprises the steps of establishing a comprehensive analysis model after collecting the environmental parameter data actually collected during the operation of a follow-up animal laboratory through obtaining the associated influence coefficient of the environmental parameter calculated in the data processing module, generating an early warning regulation signal, and transmitting the early warning regulation signal to an evaluation regulation module for evaluation calculation;
it should be noted that the building steps of the comprehensive analysis model are as follows:
the comprehensive analysis model comprehensively considers electromagnetic radiation according to environmental parameter data and associated influence coefficients For temperature/>Humidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>The influence degree of the environmental parameters of the experimental animal is comprehensively analyzed through the influence of the environmental parameter signals on the running state of the electrical equipment of the animal laboratory, so that electromagnetic radiation which influences the nervous system damage, the bad immune system, the behavior change and the genital organ change of the experimental animal in the running state of the animal laboratory is avoided, an early warning regulation signal is generated to predict potential problems, and relevant decision instructions are issued and optimized;
dynamic data of relevant environmental parameters in animal laboratory obtained after processing by data processing module Combining the correlation influence coefficient/>, obtained in the linear fitting modelTo determine the influence degree of electromagnetic field generated by the electrical equipment of animal laboratory in the running state on the laboratory environment parameters, namely generating an early warning regulation signal, and calibrating as/>The calculation formula is/>In the above, the ratio of/>Represented as the sum of the dynamic data of the modified optimized environmental parameter values, i.e./>；
The accuracy and the reliability of the comprehensive analysis model are further verified and evaluated by comparing the early warning regulation and control signals obtained through calculation in the comprehensive analysis model with actual running states, the result of the early warning regulation and control signals is explained, the influence degree of electromagnetic fields generated by electric equipment of an animal laboratory in the running states on laboratory environment parameters is analyzed, and decision support and optimization suggestions are provided for laboratory managers.
It should be noted that, the evaluation logic of the early warning regulation signal is as follows:
According to the early warning regulation and control signal The value of the pre-warning signal is compared with a preset threshold value of the environmental parameter signal in degree of deviation, and then the pre-warning grade corresponding to different degree of deviation is determined, wherein different magnitude of difference is defined according to specific pre-warning grade setting and animal laboratory set requirements, so that the emergency degree of the pre-warning signal and the adopted regulation and control measures are judged, and therefore, the environmental regulation and control system of the animal laboratory intelligently monitors the actual running state and timely adopts the treatment measures, and is used for ensuring that the normal running of the electrical equipment and the experimental environment of the animal laboratory are maintained normal without affecting the accuracy of experimental results of experimental animals.
According to the early warning grade corresponding to the early warning regulation signal, the laboratory manager and related personnel are informed of abnormal conditions in the form of sound, light signals and text prompt, and the numerical value of each environmental parameter in the laboratory is regulated and controlled, namely corresponding regulation measures are taken.
And (3) evaluating a regulation module: receiving an early warning regulation signal of the data comprehensive analysis module, evaluating according to a threshold range of a preset environmental parameter signal, regulating the environmental parameter data to a preset threshold by adopting a regulation strategy, and transmitting an evaluation result and regulation measures to an interface warning interaction module for human-computer interaction;
the content of the threshold range of the preset environmental parameter signal is as follows:
temperature in environmental parameter signals in animal laboratory The threshold range of (2) is/>In which, in the process,Expressed as minimum and maximum values of adjustable temperature constants in animal laboratory that do not affect vital signs and neurological states of experimental animals,/>Expressed as open interval, i.e. temperature/>The value range of (2) is/>Between, but does not include/>And/>Is a self-body of (2);
Humidity of the water The threshold range of (2) is/>In the above, the ratio of/>Expressed as minimum and maximum values of regulatable humidity constants in animal laboratory, respectively, which do not affect vital signs and neurological states of experimental animals,/>Expressed as open space, i.e. humidity/>The value range of (2) is/>Between, but does not include/>And/>Is a self-body of (2);
concentration of gaseous particulate matter The threshold range of (2) is/>In which, in the process,Expressed as minimum and maximum values of concentration constants of adjustable gas particles in animal laboratory without influencing vital signs and nerve states of experimental animal,/>Expressed as open space, i.e. gas particulate concentration/>The value range of (2) is/>Between, but does not include/>And/>Is a self-body of (2);
Intensity and frequency of illumination The threshold range of (2) is/>In the above, the ratio of/>Expressed as minimum and maximum values of adjustable illumination intensity and frequency constant in animal laboratory without affecting vital sign and nerve state of experimental animalExpressed as the on-interval, i.e. illumination intensity and frequency/>The value range of (2) is/>Between, but does not include/>And/>Is a self-body of (2);
noise level The threshold range of (2) is/>In the above, the ratio of/>Expressed as minimum and maximum values, respectively, of a regulatable noise level constant in an animal laboratory that does not affect vital signs and neurological states of the experimental animal,/>Expressed as left-closed right-open section, i.e. noise level/>The value range of (2) is/>Between, make/>Can be equal to 0, but is less than/>；
Electromagnetic radiationThe threshold range of (2) is/>In the above, the ratio of/>Expressed as minimum and maximum values of regulatable electromagnetic radiation constants in animal laboratory, respectively, which do not affect vital signs and neurological states of experimental animals,/>Expressed as left-closed right-open section, i.e. electromagnetic radiation/>The value range of (2) is/>Between, make/>Can be equal to 0, but is less than/>。
It should be noted that, the regulation and control measure is that the environmental regulation and control system of animal laboratory includes fresh air conditioner, intelligent humidifier, intelligent control lamp, muffler and the equipment of demagnetizer, through the early warning regulation and control signal that the prediction of dynamic data and associated influence coefficient produced in the evaluation regulation and control module, carry out the contrast evaluation to the threshold value of preset environmental parameter signal, the evaluation regulation and control module can carry out accurate regulation control to temperature, humidity, gas particle concentration, illumination intensity and frequency, noise and electromagnetic radiation, in order to realize the accurate regulation and control of animal laboratory environmental parameter, avoid regulation and control strategy to have the mistake or deviation, reduce animal laboratory because of the magnetic field that electrical equipment produced influences the change of environmental parameter when running, further reduce experimental animal's life safety, improve animal experiment data's accuracy.
Interface warning interaction module: the system adopts a man-machine interaction interface and an alarm device, receives data and instructions of all modules of the system on environmental parameters in an animal laboratory, provides warning, reporting and operation interfaces for staff, and controls and monitors the state and operation of the system in real time by an interaction mode and triggering an alarm mechanism.
It should be noted that the alarm mechanism includes the following steps:
The reverse regulation and control of the environmental parameters by the evaluation regulation and control module is carried out, so that the laboratory environment is kept in a state of not influencing vital signs of experimental animals, and an alarm mechanism is triggered when the regulation and control are improper or the power-off condition occurs;
Setting alarm conditions: setting the temperature, humidity, gas particle concentration, illumination intensity and frequency, noise and electromagnetic radiation in an animal laboratory to be threshold, and carrying out comprehensive data analysis when the abnormality exceeds the threshold in the monitoring time in the actual monitoring process, judging and comparing the data according to the set alarm condition to judge whether an alarm event occurs or not;
Triggering an alarm: if an alarm event occurs, triggering a corresponding alarm signal or personnel interaction to perform the operation of the strategy adjustment instruction according to a set alarm mechanism;
And (3) processing and alarming: processing the triggered alarm, and manually checking laboratory conditions, removing faults or taking countermeasures that environmental parameter data are regulated and controlled to be within a threshold range;
Recording and feedback: and recording and feeding back alarm events, and providing basis for subsequent management and improvement.
Example 2
As shown in fig. 2, the invention provides an environmental control method for an animal laboratory, further discloses a control step of an environmental control system for the animal laboratory in embodiment 1, and comprises the following steps of;
a sensor group and an electromagnetic radiation instrument are adopted to monitor environmental parameter signals of an animal laboratory in real time, and discrete data variables are counted along with time change to generate dynamic data related to time;
Carrying out correction optimization processing on the dynamic data to obtain predicted dynamic data, carrying out linear fitting on environmental parameter semaphores, and obtaining associated influence coefficients after comparing calculation with actual data;
according to the associated influence coefficient, a comprehensive analysis model is established, and an early warning regulation signal is generated;
And comparing and evaluating a threshold value of a preset environmental parameter signal according to the early warning regulation signal, accurately regulating and controlling the environmental parameter of the laboratory, and interacting with a human-computer interface to monitor the environmental state of the laboratory in real time.
The specific method and flow of the environmental control system of the animal laboratory provided by the embodiment of the invention are detailed in the embodiment of the environmental control system of the animal laboratory, and are not repeated here.
The above formulas are all formulas with dimensions removed and numerical values calculated, the formulas are formulas with a large amount of data collected for software simulation to obtain the latest real situation, and preset parameters in the formulas are set by those skilled in the art according to the actual situation.
The above embodiments may be implemented in whole or in part by software, hardware, firmware, or any other combination. When implemented in software, the above-described embodiments may be implemented in whole or in part in the form of a computer program product. The computer program product comprises one or more computer instructions or computer programs. When the computer instructions or computer program are loaded or executed on a computer, the processes or functions described in accordance with embodiments of the present application are produced in whole or in part. The computer may be a general purpose computer, a special purpose computer, a computer network, or other programmable apparatus. The computer instructions may be stored in a computer-readable storage medium or transmitted from one computer-readable storage medium to another computer-readable storage medium, for example, the computer instructions may be transmitted from one website site, computer, server, or data center to another website site, computer, server, or data center by wired or wireless means (e.g., infrared, wireless, microwave, etc.). The computer readable storage medium may be any available medium that can be accessed by a computer or a data storage device such as a server, data center, etc. that contains one or more sets of available media. The usable medium may be a magnetic medium (e.g., floppy disk, hard disk, magnetic tape), an optical medium (e.g., DVD), or a semiconductor medium. The semiconductor medium may be a solid state disk.
It should be understood that, in various embodiments of the present application, the sequence numbers of the foregoing processes do not mean the order of execution, and the order of execution of the processes should be determined by the functions and internal logic thereof, and should not constitute any limitation on the implementation process of the embodiments of the present application.
Those of ordinary skill in the art will appreciate that the various illustrative elements and algorithm steps described in connection with the embodiments disclosed herein may be implemented as electronic hardware, or combinations of computer software and electronic hardware. Whether such functionality is implemented as hardware or software depends upon the particular application and design constraints imposed on the solution. Skilled artisans may implement the described functionality in varying ways for each particular application, but such implementation decisions should not be interpreted as causing a departure from the scope of the present application.
The foregoing is merely illustrative of the present application, and the present application is not limited thereto, and any person skilled in the art will readily recognize that variations or substitutions are within the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (8)
1. An environmental regulation and control system in animal laboratory, which is characterized by comprising an environmental signal acquisition module: respectively acquiring environmental parameter information of an animal laboratory through a sensor group and an electromagnetic radiation instrument, and counting measurement results changing along with time to generate dynamic data related to time;
and a data processing module: receiving dynamic data transmitted by an environment signal acquisition module, carrying out correction optimization calculation on the dynamic data by adopting a data correction algorithm to obtain dynamic correction data, then establishing a linear fitting model according to the correction data, fitting the dynamic correction data to a linear relation to obtain prediction result data and actual influence data, and carrying out contrast analysis to solve the linear fitting model to obtain an associated influence coefficient of environment parameters;
And the data comprehensive analysis module: the method comprises the steps of establishing a comprehensive analysis model after collecting the environmental parameter data actually collected during the operation of a follow-up animal laboratory through obtaining the associated influence coefficient of the environmental parameter calculated in the data processing module, generating an early warning regulation signal, and transmitting the early warning regulation signal to an evaluation regulation module for evaluation calculation;
and (3) evaluating a regulation module: receiving an early warning regulation signal of the data comprehensive analysis module, evaluating according to a threshold range of a preset environmental parameter signal, regulating the environmental parameter data to a preset threshold by adopting a regulation strategy, and transmitting an evaluation result and regulation measures to an interface warning interaction module for human-computer interaction;
Interface warning interaction module: and receiving data and instructions of the system on environmental parameters in the animal laboratory from each module, providing warning, reporting and operating interfaces for staff, and controlling and monitoring the state and operation of the system in real time by an interactive mode and triggering an alarm mechanism.
2. The environmental conditioning system of claim 1, wherein the sensor group comprises a temperature sensor, a humidity sensor, a gas sensor, an illuminance sensor, and a sound sensor for real-time monitoring and collecting parameter data signals of temperature, humidity, gas particulate matter concentration, illumination intensity and frequency, and noise level in the animal laboratory, and calibrated as、/>、/>、/>、/>；
The electromagnetic radiation instrument is used for measuring radiation intensity data of electromagnetic field in animal laboratory, i.e. collecting electromagnetic radiation data of environmental parameter signal in animal laboratory, and is calibrated as；
The environmental parameter signal includes temperatureHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Is a data signal of (a);
the time change is measured by taking twenty-four hours a day as a period, sixty minutes a hour, respectively in each minute time interval Average value/>, of internal recording laboratory environmental parameter signalsMaximum/>And minimum/>Discrete point data signals of (a);
Dynamic data is recorded in real time over time The change data of each environmental parameter signal in the changed animal laboratory is marked as/>Dynamic data/>And/>，，/>In the/>Expressed as time/>Function of varying environmental parameter signals, i.e. discrete time series,/>Expressed as time/>Average value of the varying environmental parameter signal,/>Expressed as time/>Maximum value of the varying environmental parameter signal,/>Expressed as time/>Minimum value of the varying environmental parameter signal,/>Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Average taken at change,/>Expressed as/>Average value in time interval; /(I)Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Maximum value taken during change,/>Expressed as/>The maximum value in the time interval is set,Expressed as temperature/>, respectivelyHumidity/>Gas particulate concentration/>Light intensity and frequency/>Noise level/>And electromagnetic radiation/>Over time/>Minimum value taken during change,/>Expressed as/>Minimum value within the time interval.
3. An environmental conditioning system of an animal laboratory according to claim 2 wherein the logic of the data correction algorithm is as follows:
Environmental parameter signals obtained according to real-time monitoring in animal laboratories over time Mean value of the change/>Maximum valueAnd minimum/>Dynamic data/>Establishing a time series analysis prediction model and using the current time/>As input, the current time/>, is predictedEnvironmental parameter value of point/>And then the current time/>Real environmental parameter values/>, acquired in real time by pointsPerforming difference calculation to obtain correction factors, and calibrating as/>According to correction factor/>Carrying out correction optimization on the time sequence analysis prediction model, and carrying out next calculation by taking the corrected prediction value as new dynamic data;
The time sequence analysis prediction model is used for correcting data acquired by a sensor group and an electromagnetic radiometer in real time, is used for improving the monitoring acquisition precision of the sensor group and the electromagnetic radiometer and reducing the data transmission error, adopts an ARMA-like algorithm, and has a calculation formula of In the above, the ratio of/>Expressed as a constant,/>Expressed as/>Random error term of time instant,/>Expressed as/>Time series data of time instant,/>Expressed as time/>Average value of the varying environmental parameter signal,/>Expressed as time/>Maximum value of the varying environmental parameter signal,/>Expressed as time/>Minimum value of the varying environmental parameter signal,/>Represented as averages of laboratory environmental parameter signals in a time series analysis prediction model, respectivelyParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term; /(I)Expressed as maximum value/>, respectively, of laboratory environmental parameter signals in a time series analysis prediction modelParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term; /(I)Expressed as the minimum value/>, respectively, of laboratory environmental parameter signals in a time series analysis prediction modelParameters of (1)/(1)Expressed as/>Last time/>Random error term vs. current/>Influence weight of time of day,/>Expressed as/>In the past/>Random error versus current/>, for each time pointInfluence degree of time point,/>Expressed as/>At/>Influence coefficients of the moment absolute error term;
Comparing the predicted value calculated by the time sequence analysis prediction model with the actual observed value, and calculating a predicted error to obtain a correction factor I.e./>In/>For correction factor, dynamic data/>, is brought inObtaining dynamic data/>, of the environmental parameter values after correction and optimizationAnd/>。
4. The environmental control system of an animal laboratory according to claim 1, wherein the comprehensive analysis model is dynamic data of relevant environmental parameters in the animal laboratory obtained after processing by the data processing moduleCombining the correlation influence coefficient/>, obtained in the linear fitting modelTo determine the influence degree of electromagnetic field generated by the electrical equipment of animal laboratory in the running state on the laboratory environment parameters, namely generating an early warning regulation signal, and calibrating as/>The calculation formula is/>In the above, the ratio of/>Represented as the sum of the dynamic data of the modified optimized environmental parameter values, i.e./>。
5. The environmental conditioning system of claim 4, wherein the evaluation logic of the early warning conditioning signal is as follows:
According to the early warning regulation and control signal The deviation degree is compared with a preset threshold value of the environmental parameter signal, and then the early warning grade corresponding to different deviation degrees is determined;
According to the early warning grade corresponding to the early warning regulation signal, the laboratory manager and related personnel are informed of abnormal conditions in the form of sound, light signals and text prompt, and the numerical value of each environmental parameter in the laboratory is regulated and controlled, namely corresponding regulation measures are taken.
6. The environmental conditioning system of claim 5, wherein the threshold range of the preset environmental parameter signal is as follows:
temperature in environmental parameter signals in animal laboratory The threshold range of (2) is/>In which, in the process,Expressed as minimum and maximum values of adjustable temperature constants in animal laboratory that do not affect vital signs and neurological states of experimental animals,/>Expressed as open interval, i.e. temperature/>The value range of (2) is/>Between, but does not include/>And/>Is a self-contained feature of (a).
7. The environmental control system of an animal laboratory according to claim 5, wherein the control measures are equipment of a fresh air conditioner, an intelligent humidifier, a intelligent control lamp, a silencer and a demagnetizer, and the evaluation control module can accurately regulate and control temperature, humidity, gas particle concentration, illumination intensity and frequency, noise and electromagnetic radiation by evaluating pre-warning control signals generated by prediction of dynamic data and associated influence coefficients in the control module and comparing and evaluating threshold values of preset environmental parameter signals.
8. An environmental conditioning system of an animal laboratory according to claim 7, characterized in that the environmental conditioning method of the animal laboratory comprises the steps of;
a sensor group and an electromagnetic radiation instrument are adopted to monitor environmental parameter signals of an animal laboratory in real time, and discrete data variables are counted along with time change to generate dynamic data related to time;
Carrying out correction optimization processing on the dynamic data to obtain predicted dynamic data, carrying out linear fitting on environmental parameter semaphores, and obtaining associated influence coefficients after comparing calculation with actual data;
according to the associated influence coefficient, a comprehensive analysis model is established, and an early warning regulation signal is generated;
And comparing and evaluating a threshold value of a preset environmental parameter signal according to the early warning regulation signal, accurately regulating and controlling the environmental parameter of the laboratory, and interacting with a human-computer interface to monitor the environmental state of the laboratory in real time.
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