CN117619456A - Resin elution device for preparing heparin sodium crude product and process method thereof - Google Patents
Resin elution device for preparing heparin sodium crude product and process method thereof Download PDFInfo
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- CN117619456A CN117619456A CN202410111377.8A CN202410111377A CN117619456A CN 117619456 A CN117619456 A CN 117619456A CN 202410111377 A CN202410111377 A CN 202410111377A CN 117619456 A CN117619456 A CN 117619456A
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- groove
- filter frame
- heparin sodium
- barrel body
- fixedly connected
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- 229920000669 heparin Polymers 0.000 title claims abstract description 76
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title claims abstract description 76
- 229960001008 heparin sodium Drugs 0.000 title claims abstract description 76
- 229920005989 resin Polymers 0.000 title claims abstract description 75
- 239000011347 resin Substances 0.000 title claims abstract description 75
- 238000010828 elution Methods 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000008569 process Effects 0.000 title claims abstract description 11
- 239000012043 crude product Substances 0.000 title claims description 8
- 238000007599 discharging Methods 0.000 claims abstract description 13
- 238000001914 filtration Methods 0.000 claims description 33
- 239000000047 product Substances 0.000 claims description 32
- 239000007788 liquid Substances 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 14
- 238000005342 ion exchange Methods 0.000 claims description 8
- 238000007789 sealing Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 5
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 150000002500 ions Chemical class 0.000 claims description 2
- 238000000926 separation method Methods 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 6
- 238000004064 recycling Methods 0.000 description 6
- 230000008929 regeneration Effects 0.000 description 5
- 238000011069 regeneration method Methods 0.000 description 5
- 239000002245 particle Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 239000003480 eluent Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/10—Ion-exchange processes in general; Apparatus therefor with moving ion-exchange material; with ion-exchange material in suspension or in fluidised-bed form
- B01J47/11—Ion-exchange processes in general; Apparatus therefor with moving ion-exchange material; with ion-exchange material in suspension or in fluidised-bed form in rotating beds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
- B01J49/60—Cleaning or rinsing ion-exchange beds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Filtration Of Liquid (AREA)
Abstract
The invention belongs to the technical field of elution, in particular to a resin elution device for preparing a crude heparin sodium product and a process method thereof, comprising a barrel body; a servo motor is fixedly connected to the top of the barrel body; the output end of the servo motor is fixedly connected with a gear; the top of the barrel body is rotatably connected with a rotating rod, and one end of the rotating rod extends into the barrel body; the other end of the rotating rod is fixedly connected with a toothed ring; the toothed ring is meshed with the gear; the outer circumferential wall of the rotating rod is provided with a first filter frame, a second filter frame and a third filter frame respectively, the outer surfaces of the first filter frame, the second filter frame and the third filter frame are provided with collecting nets, and the top of the barrel body is provided with a feeding pipe; a discharging pipe is arranged at the bottom of the barrel body; the outer circular wall of discharging pipe is equipped with the valve, through rotatory mode, can make heparin sodium crude and resin more evenly mix, and heparin sodium and resin's area of contact is bigger, improves separation purity, optimizes separation effect.
Description
Technical Field
The invention relates to the technical field of elution, in particular to a resin elution device for preparing a crude heparin sodium product and a process method thereof.
Background
The heparin sodium crude product is a preparation form of heparin sodium, and usually contains heparin sodium active ingredients with higher purity and also contains some impurities, the heparin sodium crude product is usually required to be further processed and treated to improve the purity and remove the impurities, and finally a pure heparin sodium preparation is obtained, and when the heparin sodium crude product is eluted, resin is required to be selected to be soaked in a solution, washed and dried, then the resin is filled into a chromatographic column, then the heparin sodium crude product solution is eluted through the chromatographic column, and the collected heparin sodium solution is dried, so that the heparin sodium crude product is obtained.
In a chromatographic column filled with resin, the crude heparin sodium is put into the chromatographic column from the upper part, however, due to the nature of the crude heparin sodium, the flow rate is generally slow, so that the treatment time is increased, the crude heparin sodium is blocked in a resin layer, once the blocking occurs, the contact area of the heparin sodium and the resin is greatly reduced, the adsorption effect and the extraction efficiency of the heparin sodium are affected, the contact area of the heparin sodium and the resin is increased by stirring the resin in the prior art, the contact of the heparin sodium and the resin can be quickened briefly, so that the mixing is more uniform, but the stirring operation can bring irreversible physical damage to the resin, such as particle breakage, structural deformation and the like, the service life of the resin is shortened, the chromatographic performance of the resin is affected, and the separation purity of the heparin sodium is affected; therefore, a resin elution device for preparing a crude heparin sodium product and a process method thereof are provided for solving the problems.
Disclosure of Invention
In order to make up the defects of the prior art, the invention provides a resin elution device for preparing a crude heparin sodium product and a process method thereof.
The technical scheme adopted for solving the technical problems is as follows: the invention relates to a resin elution device for preparing a crude heparin sodium product, which comprises a barrel body; a servo motor is fixedly connected to the top of the barrel body; the output end of the servo motor is fixedly connected with a gear; the top of the barrel body is rotatably connected with a rotating rod, and one end of the rotating rod extends into the barrel body; the other end of the rotating rod is fixedly connected with a toothed ring; the toothed ring is meshed with the gear; the outer circumferential wall of the rotating rod is provided with a first filter frame, a second filter frame and a third filter frame respectively, the outer surfaces of the first filter frame, the second filter frame and the third filter frame are provided with collecting nets, and the top of the barrel body is provided with a feeding pipe; a discharging pipe is arranged at the bottom of the barrel body; and a valve is arranged on the outer circular wall of the discharging pipe.
Preferably, a return groove is formed in each frame of the first filter frame, the second filter frame and the third filter frame; the top and the bottom of the first filter frame, the second filter frame and the third filter frame are respectively provided with a group of through holes which are communicated with the return grooves; a group of first connecting pipes are fixedly connected to the top of the first filtering frame; the lower end of the first connecting pipe is communicated with a return groove in the first filter frame; the top end of the first connecting pipe extends into the return groove of the second filter frame, and the first connecting pipe is connected with the second filter frame in a sliding way; a group of second connecting pipes are fixedly connected to the top of the second filtering frame; the lower end of the second connecting pipe is communicated with a return groove in the second filter frame; the top end of the second connecting pipe extends into the return groove of the third filter frame, and the second connecting pipe is connected with the third filter frame in a sliding manner; the top of the third filter frame is connected with a third connecting pipe in a sliding manner, and the lower end of the third connecting pipe extends into a return groove of the third filter frame; and a material conveying unit is arranged at the end part of the third connecting pipe.
Preferably, the return groove consists of a first vertical groove, a second vertical groove, a first transverse groove and a second transverse groove; the first vertical groove is positioned on the frame, close to the inner side wall of the barrel body, of the first filtering frame; the vertical groove is positioned on the frame, close to the rotating rod, of the first filtering frame; the first transverse groove is positioned above the second transverse groove; the transverse groove is inclined to one side of the first vertical groove; one side of the transverse groove II is inclined to one side of the vertical groove II; the top end of the first connecting pipe is in sealed sliding connection with the bottom end of the second vertical groove of the second filter frame; the top end of the second connecting pipe is in sealing sliding connection with the bottom end of the second vertical groove of the third filter frame.
Preferably, the material conveying unit comprises an air pump; the bottom of the third connecting pipe is in sealed sliding connection with the top end of the second vertical groove of the third filter frame; the top end of the third connecting pipe is fixedly connected with a first annular shell; the edges of the two sides of the first annular shell are connected with a second annular shell in a sealing and rotating manner; the side wall of the second annular shell is fixedly connected to the top wall of the interior of the barrel body; the side wall of the second annular shell is fixedly connected with an air outlet pipe and a liquid outlet pipe respectively, and one ends of the air outlet pipe and the liquid outlet pipe extend out of the barrel body; an air pump is arranged on the outer circular wall of the air outlet pipe, and the side wall of the air pump is fixedly connected to the top of the barrel body; the outer circular wall of drain pipe is equipped with the water pump, the lateral wall rigid coupling of water pump is on the top of staving.
Preferably, a group of sliding grooves are formed in the side wall of the rotating rod; the wall of each chute is connected with a first sliding block in a sliding way; the first sliding block is fixedly connected to the inner circular walls of the first filtering frame, the second filtering frame and the third filtering frame respectively; the inner circular wall of the barrel body is provided with a first groove group, a second groove group and a third groove group from bottom to top in sequence; the outer circular walls of the first filter frame, the second filter frame and the third filter frame are fixedly connected with second sliding blocks; the second sliding blocks are respectively connected in the first groove group, the second groove group and the third groove group in a sliding manner.
Preferably, the first groove group comprises an upper annular groove, a lower annular groove and a chute; an upper annular groove and a lower annular groove are arranged in the barrel body, and the upper annular groove is connected with the lower annular groove through a chute; the second groove group and the third groove group have the same internal structure as the first groove group; the space between the upper annular groove and the lower annular groove in the second groove group is larger than the space between the upper annular groove and the lower annular groove in the first groove group, and the space between the upper annular groove and the lower annular groove in the second groove group is smaller than the space between the upper annular groove and the lower annular groove in the third groove group; the side wall of the chute is provided with a guide piece.
Preferably, the guide comprises a slide; the groove wall of the chute is provided with a groove; the side wall of the groove is connected with a sliding strip in a sealing sliding manner; a placing groove is formed in the bottom of the groove; the groove wall of the placing groove is connected with a magnetic block in a sliding way; the side wall of the magnetic block is fixedly connected to the bottom of the sliding strip; a spring is fixedly connected between the magnetic block and the placing groove; the slot wall of the placing slot is fixedly connected with an electromagnet.
Preferably, the chute is provided with an arc-shaped groove at the top of the chute wall far away from the slide bar; the groove wall of the arc-shaped groove is rotationally connected with a stop block; a torsion spring is fixedly connected between the stop block and the inner wall of the arc-shaped groove.
Preferably, a set of tooth-shaped grooves are arranged at the bottom of the upper annular groove and the bottom of the lower annular groove.
The process method of the resin elution device for preparing the crude heparin sodium product adopts the resin elution device for preparing the crude heparin sodium product, and comprises the following steps of:
s1: inputting the crude heparin sodium product into a barrel body from a feeding pipe, and starting a servo motor to drive a rotating rod to drive a first filter frame, a second filter frame and a third filter frame to rotate, so that the resin in the first filter frame, the second filter frame and the third filter frame is subjected to ion exchange with the crude heparin sodium product;
s2: the gas is input into the return grooves of the first filter frame, the second filter frame and the third filter frame through the material conveying unit, and is discharged into the barrel body through the through holes in the return grooves, so that the ion exchange efficiency of the resin and the crude heparin sodium product is improved;
s3: after ion exchange is completed between the resin and the crude heparin sodium, the crude heparin sodium is input into an eluent barrel body through a discharging pipe, the crude heparin sodium is separated from the resin by the eluent, impurities are removed to complete elution, and the eluted heparin sodium liquid is discharged from the discharging pipe and is collected.
The invention has the advantages that:
1. in the process that the servo motor operates to drive the first filter frame, the second filter frame and the third filter frame to rotate, the impact force borne by the resin particles is relatively small, the physical damage to the resin can be reduced, the service life of the resin can be prolonged, the crude heparin sodium product and the resin can be more uniformly mixed in a rotating mode, the contact area of the heparin sodium and the resin is larger, the separation purity is improved, and the separation effect is optimized;
2. when the air is released into the barrel, an upward air flow is formed, the air flow can push the crude heparin sodium to pass through the resin layer faster, the contact area between resin and heparin sodium is increased, residual liquid in the vertical groove I, the vertical groove II, the horizontal groove I and the horizontal groove II can flow out of the bottom through hole of the horizontal groove II, residual liquid is prevented from flowing in the return groove during subsequent use, and when the rotating rod rotates, the regeneration liquid flows and diffuses better in the gaps among the first filter frame, the second filter frame and the third filter frame, so that the regeneration liquid is distributed more uniformly in the resin layer, and the resin regeneration effect is improved.
Drawings
In order to more clearly illustrate the embodiments of the invention or the technical solutions of the prior art, the drawings which are used in the description of the embodiments or the prior art will be briefly described, it being obvious that the drawings in the description below are only some embodiments of the invention, and that other drawings can be obtained from these drawings without inventive faculty for a person skilled in the art.
FIG. 1 is a perspective view of the structure of the present invention;
FIG. 2 is an enlarged view of FIG. 1 at A;
FIG. 3 is a partial cross-sectional view of the present invention;
FIG. 4 is an enlarged view of FIG. 3 at B;
FIG. 5 is an enlarged view of FIG. 3 at C;
FIG. 6 is a schematic view of the internal partial structure of the tub;
FIG. 7 is an enlarged view of FIG. 6 at D;
FIG. 8 is a partial block diagram of a first filter frame;
FIG. 9 is a partial cross-sectional view of a first filter frame;
FIG. 10 is a partial cross-sectional view of a tub;
FIG. 11 is an enlarged view of FIG. 10 at E;
FIG. 12 is a partial cross-sectional view of a placement slot;
fig. 13 is a partial schematic view of a tooth-like groove.
In the figure: 1. a tub body; 2. a servo motor; 3. a gear; 4. a rotating lever; 5. a toothed ring; 6. a first filter frame; 7. a second filter frame; 8. a third filter frame; 9. a collection net; 10. a feed pipe; 11. a discharge pipe; 12. a return groove; 13. a through hole; 14. a first connection pipe; 15. a second connection pipe; 16. a third connection pipe; 17. a first vertical groove; 18. a second vertical groove; 19. a transverse groove I; 20. a transverse groove II; 21. an air pump; 22. a first annular shell; 23. a second annular shell; 24. an air outlet pipe; 25. a liquid outlet pipe; 26. a water pump; 27. a chute; 28. a first slider; 29. a first groove group; 30. a second groove group; 31. a third groove group; 32. a second slider; 33. an upper annular groove; 34. a lower annular groove; 35. a chute; 36. a slide bar; 37. a placement groove; 38. a magnetic block; 39. an electromagnet; 40. a stop block; 41. tooth-shaped grooves.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-13, a resin elution device for preparing a crude heparin sodium product comprises a barrel body 1; a servo motor 2 is fixedly connected to the top of the barrel body 1; the output end of the servo motor 2 is fixedly connected with a gear 3; the top of the barrel body 1 is rotatably connected with a rotating rod 4, and one end of the rotating rod 4 extends into the barrel body; the other end of the rotating rod 4 is fixedly connected with a toothed ring 5; the toothed ring 5 is meshed with the gear 3; the outer circular wall of the rotating rod 4 is respectively provided with a first filtering frame 6, a second filtering frame 7 and a third filtering frame 8, the outer surfaces of the first filtering frame 6, the second filtering frame 7 and the third filtering frame 8 are respectively provided with a collecting net 9, and the top of the barrel body 1 is provided with a feeding pipe 10; the bottom of the barrel body 1 is provided with a discharging pipe 11; the outer circular wall of the discharging pipe 11 is provided with a valve.
A return groove 12 is formed in each frame of the first filter frame 6, the second filter frame 7 and the third filter frame 8; the top and the bottom of the first filtering frame 6, the second filtering frame 7 and the third filtering frame 8 are respectively provided with a group of through holes 13, and the through holes 13 are communicated with the return grooves 12; a group of first connecting pipes 14 are fixedly connected to the top of the first filter frame 6; the lower end of the first connecting pipe 14 is communicated with the return groove 12 in the first filter frame 6; the top end of the first connecting pipe 14 extends into the return groove 12 of the second filter frame 7, and the first connecting pipe 14 is in sliding connection with the second filter frame 7; a group of second connecting pipes 15 are fixedly connected to the top of the second filter frame 7; the lower end of the second connecting pipe 15 is communicated with a return groove 12 in the second filtering frame 7; the top end of the second connecting pipe 15 extends into the return groove 12 of the third filter frame 8, and the second connecting pipe 15 is in sliding connection with the third filter frame 8; the top of the third filter frame 8 is slidably connected with a third connecting pipe 16, and the lower end of the third connecting pipe 16 extends into the return groove 12 of the third filter frame 8; the end of the third connecting pipe 16 is provided with a material conveying unit.
The return groove 12 consists of a first vertical groove 17, a second vertical groove 18, a first transverse groove 19 and a second transverse groove 20; the first vertical groove 17 is positioned on the frame of the first filter frame 6 close to the inner side wall of the barrel body 1; the second vertical groove 18 is positioned on the frame of the first filter frame 6 close to the rotating rod 4; the first transverse groove 19 is positioned above the second transverse groove 20; the transverse groove I19 is inclined to one side of the vertical groove I17; the second transverse groove 20 is inclined to one side of the second vertical groove 18; the top end of the first connecting pipe 14 is in sealed sliding connection with the bottom end of the second vertical groove 18 of the second filter frame 7; the top end of the second connecting pipe 15 is in sealed sliding connection with the bottom end of a second vertical groove 18 of the third filter frame 8; when the recycling device works, the first transverse groove 19 inclines to one side of the first vertical groove 17, the second transverse groove 20 inclines to one side of the second vertical groove 18, residual recycling liquid exists in the recycling groove 12 when the recycling liquid is input into the barrel body 1 by the material conveying unit, the residual liquid in the first transverse groove 17, the second vertical groove 18, the first transverse groove 19 and the second transverse groove 20 flows out from the bottom through hole 13 of the second transverse groove 20 through the oblique distribution of the first transverse groove 19 and the second transverse groove 20, and the residual liquid in the recycling groove 12 is prevented from being left in the subsequent use.
The material conveying unit comprises an air pump 21; the bottom of the third connecting pipe 16 is in sealed sliding connection with the top end of a second vertical groove 18 of the third filter frame 8; the top end of the third connecting pipe 16 is fixedly connected with a first annular shell 22; the two side edges of the first annular shell 22 are connected with a second annular shell 23 in a sealing and rotating manner; the side wall of the second annular shell 23 is fixedly connected to the top wall of the interior of the barrel body 1; the side wall of the second annular shell 23 is fixedly connected with an air outlet pipe 24 and a liquid outlet pipe 25 respectively, and one ends of the air outlet pipe 24 and the liquid outlet pipe 25 extend out of the barrel body 1; an air pump 21 is arranged on the outer circular wall of the air outlet pipe 24, and the side wall of the air pump 21 is fixedly connected to the top of the barrel body 1; the outer circular wall of the liquid outlet pipe 25 is provided with a water pump 26, and the side wall of the water pump 26 is fixedly connected to the top of the barrel body 1; during operation, gas and liquid are respectively input into the second annular shell 23 from the gas outlet pipe 24 and the liquid outlet pipe 25 through the water pump 26 of the gas pump 21 and the liquid outlet pipe 25 on the gas outlet pipe 24, the gas and the liquid enter the third connecting pipe 16 from the first annular shell 22 under the sealed rotation connection between the second annular shell 23 and the first annular shell 22, and then the gas and the liquid are injected into the circular groove 12 of the third filter frame 8 through the third connecting pipe 16, so that the gas and the liquid are introduced into the barrel body 1 from the outside.
The side wall of the rotating rod 4 is provided with a group of sliding grooves 27; the wall of each chute 27 is slidably connected with a first sliding block 28; the first sliding blocks 28 are fixedly connected to the inner circular walls of the first filter frame 6, the second filter frame 7 and the third filter frame 8 respectively; the inner circular wall of the barrel body 1 is provided with a first groove group 29, a second groove group 30 and a third groove group 31 in sequence from bottom to top; the outer circular walls of the first filter frame 6, the second filter frame 7 and the third filter frame 8 are fixedly connected with second sliding blocks 32; a set of said second sliders 32 are slidably connected in the first groove set 29, the second groove set 30 and the third groove set 31, respectively.
The first groove set 29 includes an upper annular groove 33, a lower annular groove 34, and a chute 35; an upper annular groove 33 and a lower annular groove 34 are arranged in the barrel body 1, and the upper annular groove 33 is connected with the lower annular groove 34 through a chute 35; the second groove group 30 and the third groove group 31 have the same internal structure as the first groove group 29; the interval between the upper annular groove 33 and the lower annular groove 34 in the second groove group 30 is larger than the interval between the upper annular groove 33 and the lower annular groove 34 in the first groove group 29, and the interval between the upper annular groove 33 and the lower annular groove 34 in the second groove group 30 is smaller than the interval between the upper annular groove 33 and the lower annular groove 34 in the third groove group 31; the side walls of the chute 35 are provided with guides.
The guide includes a slide 36; the groove wall of the chute 35 is provided with a groove; the side wall of the groove is connected with a sliding strip 36 in a sealing sliding manner; a placing groove 37 is formed in the bottom of the groove; the groove wall of the placing groove 37 is connected with a magnetic block 38 in a sliding way; the side wall of the magnetic block 38 is fixedly connected to the bottom of the slide bar 36; a spring is fixedly connected between the magnetic block 38 and the placing groove 37; the wall of the placing groove 37 is fixedly connected with an electromagnet 39; when the servo motor 2 rotates reversely, the second sliding block 32 on the upper annular groove 33 returns to the lower annular groove 34 along the chute 35, so that the second sliding block 32 can switch between the upper annular groove 33 and the lower annular groove 34.
An arc-shaped groove is arranged at the top of the groove wall of the chute 35 far away from the sliding strip 36; the groove wall of the arc-shaped groove is rotatably connected with a stop block 40; a torsion spring is fixedly connected between the stop block 40 and the inner wall of the arc-shaped groove; in operation, through rotation of the stopper 40 in the arcuate slot, when the second slider 32 slides back to the lower annular slot 34 in the upper annular slot 33, the second slider 32 contacts the stopper 40 at the top end of the chute 35, the second slider 32 is diagonally pressed into the chute 35 by the stopper 40 and slides into the arcuate slot along the chute 35, and when the second slider 32 contacts the stopper 40 in the upper annular slot 33 during clockwise rotation, the stopper 40 is pressed down by the second slider 32 due to the action of the torsion spring, so that the second slider 32 passes through the stopper 40, and then the stopper 40 returns to the original position due to the action of the torsion spring, so that the second slider 32 returns to the lower annular slot 34 during counterclockwise rotation.
The bottom of the upper annular groove 33 and the bottom of the lower annular groove 34 are each provided with a set of toothed grooves 41.
The process method of the resin elution device for preparing the crude heparin sodium product adopts the resin elution device for preparing the crude heparin sodium product, and comprises the following steps of:
s1: the crude heparin sodium product is input into the barrel body 1 from the feed pipe 10, the servo motor 2 is started to drive the rotating rod 4 to drive the first filter frame 6, the second filter frame 7 and the third filter frame 8 to rotate, so that the resin in the first filter frame 6, the second filter frame 7 and the third filter frame 8 is subjected to ion exchange with the crude heparin sodium product;
s2: the gas is input into the return grooves 12 of the first filter frame 6, the second filter frame 7 and the third filter frame 8 through the material conveying unit, the gas is discharged into the barrel body 1 in the return grooves 12 through the through holes 13, and the ion exchange efficiency of the resin and the crude heparin sodium product is accelerated;
s3: after ion exchange is completed between the resin and the crude heparin sodium, the crude heparin sodium is input into the barrel body 1 through the discharge pipe 11, the crude heparin sodium is separated from the resin by the eluent, impurities are removed to complete elution, and the eluted heparin sodium liquid is discharged from the discharge pipe 11 and is collected.
According to the working principle, the gear 3 is driven to rotate through the output end of the servo motor 2, the gear 3 rotates to drive the toothed ring 5 to rotate, the toothed ring 5 rotates to drive the rotating rod 4 to rotate, then the rotating rod 4 rotates to drive the first filtering frame 6, the second filtering frame 7 and the third filtering frame 8 to rotate, when resins are stored in the first filtering frame 6, the second filtering frame 7 and the third filtering frame 8, the crude heparin sodium product is input into the barrel body 1 from the feed pipe 10, the resin is prevented from overflowing out of the frame through the collecting net 9, the crude heparin sodium product can enter the frame to exchange ions with the resin, the eluted heparin sodium product enters the barrel body 1 from the feed pipe 10 to elute the heparin sodium product on the resin, the eluted heparin sodium product is sent out from the discharge pipe 11 of the barrel body 1, compared with the traditional stirring mode that the resin is directly stirred by using the stirring blade, in the process of driving the first filter frame 6, the second filter frame 7 and the third filter frame 8 to rotate by the operation of the servo motor 2, the impact force to resin particles is relatively small, the physical damage to the resin can be reduced, the service life of the resin particles is prolonged, the crude heparin sodium and the resin can be more uniformly mixed in a rotating mode, the contact area between the heparin sodium and the resin is larger, the separation purity is improved, the separation effect is optimized, the gas is input into the return groove 12 of the third filter frame 8 from the third connecting pipe 16 through the material conveying unit, the gas is input into the return groove 12 of the second filter frame 7 from the second connecting pipe 15 in the third filter frame 8, then enters the return groove 12 of the first filter frame 6 from the first connecting pipe 14 of the second filter frame 7, the gas is discharged into the barrel body 1 through the through hole 13, when the air is released into the barrel, an upward air flow is formed, the air flow can push the crude heparin sodium to more quickly pass through the resin layer, the contact area of the resin and the heparin sodium is increased, and a certain gap is formed when air flows in the resin, so that the resin can be prevented from being blocked, the treatment time is shortened, and the production efficiency is improved; after the crude heparin sodium product is eluted, the regeneration liquid can be input into the barrel body 1 through the material conveying unit, so that the resin can be regenerated for convenient recycling; since the second slider 32 on the first filter frame 6, the second filter frame 7 and the third filter frame 8 slides in the first groove group 29, the second groove group 30 and the third groove group 31 respectively, when the first filter frame 6, the second filter frame 7 and the third filter frame 8 rotate on the rotating rod 4, the distance between the first filter frame 6, the second filter frame 7 and the third filter frame 8 can be enlarged, the first slider 28 slides in the sliding groove 27, the distance enlargement does not affect the rotation of the first filter frame 6, the second filter frame 7 and the third filter frame 8 along with the rotating rod 4, the better flow and diffusion of the regenerated liquid in the gaps among the first filter frame 6, the second filter frame 7 and the third filter frame 8 can be realized, the regenerated liquid can be distributed more uniformly in the resin layer, the resin regeneration effect can be improved, the efficiency can be improved by arranging a set of toothed grooves 41 at the bottom of the upper part and the lower part of the lower 34, and the annular groove 33, and the air can be conveniently discharged from the annular groove 32 when the second slider 33 and the annular groove 34 slide out of the annular groove 41 can also contact the resin.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing has shown and described the basic principles, principal features and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, and that the above embodiments and descriptions are merely illustrative of the principles of the present invention, and various changes and modifications may be made without departing from the spirit and scope of the invention, which is defined in the appended claims.
Claims (10)
1. The resin elution device for preparing the heparin sodium crude product is characterized in that: comprises a barrel body (1); a servo motor (2) is fixedly connected to the top of the barrel body (1); the output end of the servo motor (2) is fixedly connected with a gear (3); the top of the barrel body (1) is rotatably connected with a rotating rod (4), and one end of the rotating rod (4) extends into the barrel body; the other end of the rotating rod (4) is fixedly connected with a toothed ring (5); the toothed ring (5) is meshed with the gear (3); the outer circular wall of the rotating rod (4) is respectively provided with a first filtering frame (6), a second filtering frame (7) and a third filtering frame (8), the outer surfaces of the first filtering frame (6), the second filtering frame (7) and the third filtering frame (8) are respectively provided with a collecting net (9), and the top of the barrel body (1) is provided with a feeding pipe (10); a discharging pipe (11) is arranged at the bottom of the barrel body (1); the outer circular wall of the discharging pipe (11) is provided with a valve.
2. The resin elution device for preparing a crude heparin sodium product according to claim 1, wherein: a return groove (12) is formed in each frame of the first filter frame (6), the second filter frame (7) and the third filter frame (8); the top and the bottom of the first filter frame (6), the second filter frame (7) and the third filter frame (8) are respectively provided with a group of through holes (13), and the through holes (13) are communicated with the return grooves (12); a group of first connecting pipes (14) are fixedly connected to the top of the first filtering frame (6); the lower end of the first connecting pipe (14) is communicated with a return groove (12) in the first filter frame (6); the top end of the first connecting pipe (14) extends into the return groove (12) of the second filter frame (7), and the first connecting pipe (14) is in sliding connection with the second filter frame (7); a group of second connecting pipes (15) are fixedly connected to the top of the second filtering frame (7); the lower end of the second connecting pipe (15) is communicated with a return groove (12) in the second filtering frame (7); the top end of the second connecting pipe (15) extends into the return groove (12) of the third filter frame (8), and the second connecting pipe (15) is in sliding connection with the third filter frame (8); the top of the third filter frame (8) is connected with a third connecting pipe (16) in a sliding way, and the lower end of the third connecting pipe (16) extends into a return groove (12) of the third filter frame (8); the top end of the third connecting pipe (16) is provided with a material conveying unit.
3. The resin elution device for preparing a crude heparin sodium product according to claim 2, wherein: the return groove (12) consists of a first vertical groove (17), a second vertical groove (18), a first transverse groove (19) and a second transverse groove (20); the first vertical groove (17) is positioned on a frame, close to the inner side wall of the barrel body (1), of the first filtering frame (6); the second vertical groove (18) is positioned on the frame, close to the rotating rod (4), of the first filter frame (6); the transverse groove I (19) is positioned above the transverse groove II (20); the transverse groove I (19) is inclined to one side of the vertical groove I (17); the second transverse groove (20) is inclined to one side of the second vertical groove (18); the top end of the first connecting pipe (14) is in sealed sliding connection with the bottom end of a second vertical groove (18) of the second filter frame (7); the top end of the second connecting pipe (15) is in sealing sliding connection with the bottom end of a second vertical groove (18) of the third filter frame (8).
4. A resin elution device for preparing a crude heparin sodium product according to claim 3, wherein: the material conveying unit comprises an air pump (21); the bottom of the third connecting pipe (16) is in sealed sliding connection with the top end of a second vertical groove (18) of the third filter frame (8); the top end of the third connecting pipe (16) is fixedly connected with a first annular shell (22); the edges of the two sides of the first annular shell (22) are connected with a second annular shell (23) in a sealing and rotating manner; the side wall of the second annular shell (23) is fixedly connected to the top wall of the interior of the barrel body (1); the side wall of the second annular shell (23) is fixedly connected with an air outlet pipe (24) and a liquid outlet pipe (25) respectively, and one ends of the air outlet pipe (24) and the liquid outlet pipe (25) extend out of the barrel body (1); an air pump (21) is arranged on the outer circular wall of the air outlet pipe (24), and the side wall of the air pump (21) is fixedly connected to the top of the barrel body (1); the outer circular wall of drain pipe (25) is equipped with water pump (26), the lateral wall rigid coupling of water pump (26) is on the top of staving (1).
5. The resin elution device for preparing a crude heparin sodium product according to claim 4, wherein: the side wall of the rotating rod (4) is provided with a group of sliding grooves (27); the groove wall of each sliding groove (27) is connected with a first sliding block (28) in a sliding way; the first sliding blocks (28) are fixedly connected to the inner circular walls of the first filter frame (6), the second filter frame (7) and the third filter frame (8) respectively; the inner circular wall of the barrel body (1) is provided with a first groove group (29), a second groove group (30) and a third groove group (31) from bottom to top in sequence; the outer circular walls of the first filter frame (6), the second filter frame (7) and the third filter frame (8) are fixedly connected with second sliding blocks (32); a set of second sliding blocks (32) are respectively and slidably connected in the first groove set (29), the second groove set (30) and the third groove set (31).
6. The resin elution device for preparing a crude heparin sodium product according to claim 5, wherein: the first groove group (29) comprises an upper annular groove (33), a lower annular groove (34) and a chute (35); an upper annular groove (33) and a lower annular groove (34) are arranged in the barrel body (1), and the upper annular groove (33) is connected with the lower annular groove (34) through a chute (35); the second groove group (30) and the third groove group (31) have the same internal structure as the first groove group (29); the interval between the upper annular groove (33) and the lower annular groove (34) in the second groove group (30) is larger than the interval between the upper annular groove (33) and the lower annular groove (34) in the first groove group (29), and the interval between the upper annular groove (33) and the lower annular groove (34) in the second groove group (30) is smaller than the interval between the upper annular groove (33) and the lower annular groove (34) in the third groove group (31); the side wall of the chute (35) is provided with a guide.
7. The resin elution device for preparing a crude heparin sodium product according to claim 6, wherein: the guide comprises a slide (36); the groove wall of the chute (35) is provided with a groove; the side wall of the groove is connected with a sliding strip (36) in a sealing sliding manner; a placing groove (37) is formed in the bottom of the groove; the groove wall of the placing groove (37) is connected with a magnetic block (38) in a sliding way; the side wall of the magnetic block (38) is fixedly connected to the bottom of the slide bar (36); a spring is fixedly connected between the magnetic block (38) and the placing groove (37); an electromagnet (39) is fixedly connected to the groove wall of the placing groove (37).
8. The resin elution device for preparing a crude heparin sodium product according to claim 7, wherein: an arc-shaped groove is formed at the top of the groove wall of the chute (35) far away from the sliding strip (36); the groove wall of the arc-shaped groove is rotatably connected with a stop block (40); a torsion spring is fixedly connected between the stop block (40) and the inner wall of the arc-shaped groove.
9. The resin elution device for preparing a crude heparin sodium product according to claim 8, wherein: the bottoms of the upper annular groove (33) and the lower annular groove (34) are respectively provided with a group of tooth-shaped grooves (41).
10. A process method of a resin elution device for preparing a crude heparin sodium product, which adopts the resin elution device for preparing the crude heparin sodium product according to claim 9, and is characterized in that: comprises the following steps:
s1: inputting the crude heparin sodium into a barrel body (1) from a feed pipe (10), starting a servo motor (2) to drive a rotating rod (4) to drive a first filter frame (6), a second filter frame (7) and a third filter frame (8) to rotate, and enabling resins in the first filter frame (6), the second filter frame (7) and the third filter frame (8) to exchange ions with the crude heparin sodium;
s2: inputting gas into a return groove (12) of the first filter frame (6), the second filter frame (7) and the third filter frame (8) through a material conveying unit, and discharging the gas into a barrel body (1) through a through hole (13) in the return groove (12), so that the ion exchange efficiency of resin and crude heparin sodium is improved;
s3: after ion exchange is completed between the resin and the crude heparin sodium, the eluting solution is input into the barrel body (1) through the discharging pipe (11), the eluting solution separates the crude heparin sodium from the resin, impurities are removed to complete elution, and the eluted heparin sodium solution is discharged from the discharging pipe (11) and is collected.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410111377.8A CN117619456A (en) | 2024-01-26 | 2024-01-26 | Resin elution device for preparing heparin sodium crude product and process method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202410111377.8A CN117619456A (en) | 2024-01-26 | 2024-01-26 | Resin elution device for preparing heparin sodium crude product and process method thereof |
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| CN202410111377.8A Pending CN117619456A (en) | 2024-01-26 | 2024-01-26 | Resin elution device for preparing heparin sodium crude product and process method thereof |
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