CN117618496A - Myopia debugging paste - Google Patents
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- CN117618496A CN117618496A CN202311699120.0A CN202311699120A CN117618496A CN 117618496 A CN117618496 A CN 117618496A CN 202311699120 A CN202311699120 A CN 202311699120A CN 117618496 A CN117618496 A CN 117618496A
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- borneol
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- 230000004379 myopia Effects 0.000 title claims abstract description 29
- 208000001491 myopia Diseases 0.000 title claims abstract description 29
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 12
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940116229 borneol Drugs 0.000 claims abstract description 11
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 11
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 11
- 241000205585 Aquilegia canadensis Species 0.000 claims abstract description 8
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 8
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 8
- 235000007516 Chrysanthemum Nutrition 0.000 claims abstract description 8
- 244000189548 Chrysanthemum x morifolium Species 0.000 claims abstract description 8
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 8
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 8
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 8
- 240000000233 Melia azedarach Species 0.000 claims abstract description 8
- 235000017784 Mespilus germanica Nutrition 0.000 claims abstract description 8
- 244000182216 Mimusops elengi Species 0.000 claims abstract description 8
- 235000000560 Mimusops elengi Nutrition 0.000 claims abstract description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 8
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 8
- 235000007837 Vangueria infausta Nutrition 0.000 claims abstract description 8
- 235000008434 ginseng Nutrition 0.000 claims abstract description 8
- MUKYLHIZBOASDM-UHFFFAOYSA-N 2-[carbamimidoyl(methyl)amino]acetic acid 2,3,4,5,6-pentahydroxyhexanoic acid Chemical compound NC(=N)N(C)CC(O)=O.OCC(O)C(O)C(O)C(O)C(O)=O MUKYLHIZBOASDM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 7
- 241000212322 Levisticum officinale Species 0.000 claims abstract description 7
- 241001633106 Lithocarpus Species 0.000 claims abstract description 7
- 241000159213 Zygophyllaceae Species 0.000 claims abstract description 7
- 239000001645 levisticum officinale Substances 0.000 claims abstract description 7
- 235000009165 saligot Nutrition 0.000 claims abstract description 7
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 6
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940041616 menthol Drugs 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 235000005412 red sage Nutrition 0.000 claims abstract description 4
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 14
- 239000006071 cream Substances 0.000 claims description 8
- 240000004371 Panax ginseng Species 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- 244000246386 Mentha pulegium Species 0.000 claims description 5
- 235000016257 Mentha pulegium Nutrition 0.000 claims description 5
- 235000004357 Mentha x piperita Nutrition 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 235000001050 hortel pimenta Nutrition 0.000 claims description 5
- 235000017276 Salvia Nutrition 0.000 claims description 4
- 230000003750 conditioning effect Effects 0.000 claims description 4
- 235000012716 cod liver oil Nutrition 0.000 claims description 3
- 239000003026 cod liver oil Substances 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 239000000341 volatile oil Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 244000061520 Angelica archangelica Species 0.000 claims 1
- 241000510667 Conioselinum Species 0.000 claims 1
- 235000001287 Guettarda speciosa Nutrition 0.000 claims 1
- 102000004407 Lactalbumin Human genes 0.000 claims 1
- 108090000942 Lactalbumin Proteins 0.000 claims 1
- 230000004438 eyesight Effects 0.000 abstract description 10
- 238000000034 method Methods 0.000 abstract description 10
- 239000002674 ointment Substances 0.000 abstract description 10
- 238000001467 acupuncture Methods 0.000 abstract description 4
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- 210000004185 liver Anatomy 0.000 abstract description 4
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- 231100000331 toxic Toxicity 0.000 abstract description 2
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- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 230000004304 visual acuity Effects 0.000 description 9
- 238000003745 diagnosis Methods 0.000 description 3
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- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- SZGZILRQIYNODJ-UHFFFAOYSA-L disodium;7,12-dihydroquinoxalino[3,2-b]phenazine-2,9-disulfonate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)C1=CC=C2N=C(C=C3C(NC4=CC=C(C=C4N3)S(=O)(=O)[O-])=C3)C3=NC2=C1 SZGZILRQIYNODJ-UHFFFAOYSA-L 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 208000006550 Mydriasis Diseases 0.000 description 1
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Abstract
The invention discloses myopia debugging paste which comprises the following raw materials in parts by weight: 25-35 parts of safflower, 15-25 parts of szechuan lovage rhizome, 12-20 parts of Chinese angelica, 12-20 parts of cassia seed, 12-20 parts of chrysanthemum, 12-20 parts of medlar, 12-20 parts of ginseng, 15-25 parts of red sage root, 9-15 parts of caltrop, 9-15 parts of lithocarpus, 9-15 parts of cape jasmine, 9-15 parts of szechwan chinaberry fruit, 9-15 parts of pearl, 15-25 parts of honeysuckle, 1-3 parts of menthol and 1-3 parts of borneol. Compared with the prior art, the invention has the advantages that: the external ointment for preventing and treating teenager myopia is prepared from 16 pure natural Chinese herbal medicines with the functions of aromatic resuscitation, blood circulation activating, collateral dredging, liver nourishing and eyesight improving, has the advantages of simple, convenient, cheap and tested dosage forms, overcomes the defects of poor patient compliance and the like when the teenager myopia is treated by the traditional methods of oral administration, acupuncture, excimer laser operation and the like, and reduces the toxic and side effects of oral administration.
Description
Technical Field
The invention relates to the technical field of medical care, in particular to a myopic eye debugging paste.
Background
The vision screening result of students in China shows that 32.5% of pupil, 59.4% of junior middle school students, 77.3% of senior high school students and 80% of college students are the focus of social attention, and 6 days of China is defined as loving one's eyes every 6 months. In recent years, many methods for treating myopia have been reported in various countries around the world, such as: acupuncture, oral granule, patch, etc., but practice shows that these methods have the defects of slow onset of action and easy rebound, while oral administration of the medicine is required for a long period of time, and patients suffer from injury of liver, kidney and spleen and stomach caused by taking the medicine in a large amount for a long period of time. Although advanced and rapid treatment methods such as excimer laser surgery and cornea are introduced in recent years, the methods are difficult to popularize and apply because of the high charge, the danger of surgery and the age limit of the method above eighteen years. Therefore, searching for a new method which is scientific, safe and free of side effects is a very urgent problem at present.
Disclosure of Invention
The invention aims to solve the problems in the prior art, and further provides the myopia debugging paste which has the advantages of simple, convenient, cheap and tested dosage forms and overcomes the defects of the traditional methods of oral administration, acupuncture, excimer laser surgery and the like for treating teenager myopia, poor patient compliance and the like.
The invention aims at realizing the following technical scheme:
the myopia debugging paste comprises the following raw materials in parts by weight: 25-35 parts of safflower, 15-25 parts of szechuan lovage rhizome, 12-20 parts of Chinese angelica, 12-20 parts of cassia seed, 12-20 parts of chrysanthemum, 12-20 parts of medlar, 12-20 parts of ginseng, 15-25 parts of red sage root, 9-15 parts of caltrop, 9-15 parts of lithocarpus, 9-15 parts of cape jasmine, 9-15 parts of szechwan chinaberry fruit, 9-15 parts of pearl, 15-25 parts of honeysuckle, 1-3 parts of menthol and 1-3 parts of borneol.
Further, the material comprises the following raw materials in parts by weight; 30 parts of safflower, 20 parts of szechuan lovage rhizome, 15 parts of Chinese angelica, 15 parts of cassia seed, 15 parts of chrysanthemum, 15 parts of medlar, 15 parts of ginseng, 20 parts of red-rooted salvia root, 10 parts of caltrop, 10 parts of lithocarpus fruit, 10 parts of gardenia, 10 parts of szechwan chinaberry fruit, 10 parts of pearl, 20 parts of honeysuckle, 2 parts of menthol and 2 parts of borneol.
The preparation method of the myopia debugging paste comprises the steps of mixing safflower, szechuan lovage rhizome, chinese angelica, cassia seed, chrysanthemum, medlar, ginseng, red-rooted salvia root, tribulus terrestris, corktree seed, gardenia, szechwan chinaberry fruit, pearl and honeysuckle according to parts by weight, adding water to extract volatile oil, decocting medicinal residues, concentrating, adding opalescent cod liver oil, peppermint and borneol, stirring in sequence, and preparing into paste; packaging, sterilizing, wherein the concentration of the preparation is 2.5g of crude drug per g of the conditioning cream, wherein the peppermint and the borneol are respectively prepared by 0.05g.
Compared with the prior art, the invention has the advantages that:
a plurality of pure natural Chinese herbal medicines with the functions of aromatic resuscitation, blood circulation activating, vein relaxing, liver nourishing and eyesight improving are selected as raw materials, and the external ointment for preventing and treating teenager myopia is prepared. The ointment has the advantages of simple, convenient, cheap and tested dosage forms, overcomes the defects of poor patient compliance and the like when the traditional oral administration, acupuncture, excimer laser surgery and other methods are used for treating teenager myopia, and reduces the toxic and side effects of the oral administration.
Detailed Description
The external ointment for preventing and treating teenager myopia has the functions of inducing resuscitation with aromatics, promoting blood circulation to remove meridian obstruction and nourishing liver
Improving eyesight. Clinical application proves that 0.5g of ointment is applied to the four white points, including the eye periphery, jingming, zanzhu, fish waist, yuzhu, chengqi, and the temple is applied, the patient is instructed to knead the above points to assist in medicine absorption after applying the ointment, the patient is relaxed after applying the ointment, and the ointment is wiped clean by clean soft paper after closing the eyes for 30 minutes. The Chinese medicinal ointment for external use for preventing and treating teenager myopia has the advantages that the Chinese medicinal ointment is used for treating teenager myopia, and can effectively prevent the development of teenager myopia by taking one course of treatment once every day and twice a day in noon and at night, and generally using 1-3 courses of treatment, and has an effective rate of 86.7 percent for preventing and treating teenager myopia in the early stage, and is ideal for preventing and treating teenager myopia.
The paste for regulating myopia is prepared by weighing 16 Chinese herbal medicines meeting the quality regulation of Chinese pharmacopoeia: 150g of safflower, 100g of szechuan lovage rhizome, 75g of Chinese angelica, 75g of cassia seed, 75g of chrysanthemum, 75g of medlar, 75g of ginseng, 100g of red-rooted salvia root, 50g of caltrop, 50g of lithocarpus fruit, 50g of gardenia, 50g of szechwan chinaberry fruit, 50g of pearl, 100g of honeysuckle, 10g of menthol and 10g of borneol.
Mixing with herba Menthae and Borneolum Syntheticum, extracting volatile oil with water, decocting the residue, concentrating, adding cod liver oil, herba Menthae and Borneolum Syntheticum, stirring, and concocting into paste; encapsulating and sterilizing. The concentration of the preparation is 2.5g of crude drug per g of the conditioning cream, wherein, each 0.05g of peppermint and borneol.
According to the traditional Chinese medicine diagnosis standard of myopia: the Chinese medicine preparation is formulated according to the teaching materials of higher medical institutions, namely 'traditional Chinese medicine ophthalmology', published in 2002 by Chinese traditional medicine publishing society. 1. Clear near objects, blurred far objects; 2. mydriasis is a myopic person.
Inclusion of case criteria: 1. meets the myopia diagnosis standard; 2. the whole body condition is good, and the daily treatment can be adhered to; 3. the age is more than or equal to 6 years old and less than or equal to 16 years old.
Patients meeting the diagnosis standard are randomly divided into 30 treatment groups (treatment group patients adopt the vision regulating cream, control group patients adopt the eye care myopia therapeutic apparatus for treatment) according to the treatment sequence, wherein the treatment groups comprise 12 men, 24 eyes, 18 women and 36 eyes, the average age is 12 years, and the course of disease is half a year to 3 years. 30 cases of control group, 14 cases of men, 28 eyes, 16 cases of women, 32 eyes, average age 13 years, half a year to 3 years of disease course.
The general case is as follows:
standard of efficacy: the normal logarithmic visual acuity chart is used as a standard, the visual acuity chart is recovered (the naked eye visual acuity after a treatment course is improved by more than or equal to 1.0), the visual acuity is obvious (the naked eye visual acuity after a treatment course is improved by more than three lines), the visual acuity is effective (the naked eye visual acuity after a treatment course is improved by more than two lines), and the visual acuity is ineffective (the naked eye visual acuity after a treatment course is unchanged or is up and down). The above methods all take 30 days as a treatment course, and the treatment effect is observed after one treatment course.
Treatment results: comparison of the efficacy of the two groups (see table below):
the treatment group showed significant differences in p < 0.05 compared to the control group, indicating that the treatment group was superior to the control group.
Case 1:
king was X, men, 12 years old, found myopia for more than two years, measured the naked eye's vision: left eye: 0.3; right eye: 0.5; taking 0.5g of myopia regulating cream, sequentially applying the cream to the eyes, jingming, zanzhu, fish waist, yuzhu, chengqi, sibai acupoints, applying the temple to the acupoints, ordering the patient to massage the acupoints to assist in drug absorption, loosening the patient after the medicine application, and wiping the cream with clean soft paper after closing the eyes for 30 minutes. The naked eye vision is measured twice a day, at noon and once at night and after one month: left eye: 0.9; right eye: 1.0; patients are ordered to adhere to the medicine for one year, and the eyesight of both eyes is kept above 1.0 along with the access.
Case 2
Dian x, female, age 10, find myopia one year, measure naked eye vision: left eye: 0.6; right eye: 0.7; the myopia conditioning cream is externally applied around eyes twice a day, at noon and once at night, and after one month, the vision of the naked eyes is measured: left eye: 1.5; right eye: 1.5; patients are ordered to adhere to the drug, and no recurrence is found in the follow-up visit for two years.
Claims (3)
1. The myopia debugging paste is characterized by comprising the following raw materials in parts by weight: 25-35 parts of safflower, 15-25 parts of szechuan lovage rhizome, 12-20 parts of Chinese angelica, 12-20 parts of cassia seed, 12-20 parts of chrysanthemum, 12-20 parts of medlar, 12-20 parts of ginseng, 15-25 parts of red sage root, 9-15 parts of caltrop, 9-15 parts of lithocarpus, 9-15 parts of cape jasmine, 9-15 parts of szechwan chinaberry fruit, 9-15 parts of pearl, 15-25 parts of honeysuckle, 1-3 parts of menthol and 1-3 parts of borneol.
2. The myopia debugging paste according to claim 1, wherein the paste comprises the following raw materials in parts by weight; 30 parts of safflower, 20 parts of szechuan lovage rhizome, 15 parts of Chinese angelica, 15 parts of cassia seed, 15 parts of chrysanthemum, 15 parts of medlar, 15 parts of ginseng, 20 parts of red-rooted salvia root, 10 parts of caltrop, 10 parts of lithocarpus fruit, 10 parts of gardenia, 10 parts of szechwan chinaberry fruit, 10 parts of pearl, 20 parts of honeysuckle, 2 parts of menthol and 2 parts of borneol.
3. The preparation method of the myopia debugging paste according to any one of claims 1-2, wherein the safflower, the hemlock parsley, the angelica, the cassia seed, the chrysanthemum, the medlar, the ginseng, the red sage root, the caltrop, the lithocarpus fruit, the gardenia, the szechwan chinaberry fruit, the pearl and the honeysuckle are mixed according to parts by weight, water is added to extract volatile oil, the decoction dregs are decocted, concentrated, the lactalbumin cod liver oil, the peppermint and the borneol are added, and stirring is sequentially carried out, so that the paste is prepared; packaging, sterilizing, wherein the concentration of the preparation is 2.5g of crude drug per g of the conditioning cream, wherein the peppermint and the borneol are respectively prepared by 0.05g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311699120.0A CN117618496A (en) | 2023-12-12 | 2023-12-12 | Myopia debugging paste |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311699120.0A CN117618496A (en) | 2023-12-12 | 2023-12-12 | Myopia debugging paste |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117618496A true CN117618496A (en) | 2024-03-01 |
Family
ID=90018181
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311699120.0A Pending CN117618496A (en) | 2023-12-12 | 2023-12-12 | Myopia debugging paste |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117618496A (en) |
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2023
- 2023-12-12 CN CN202311699120.0A patent/CN117618496A/en active Pending
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