CN117414364A - Anti-aging composition and related application thereof - Google Patents
Anti-aging composition and related application thereof Download PDFInfo
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- CN117414364A CN117414364A CN202311633965.XA CN202311633965A CN117414364A CN 117414364 A CN117414364 A CN 117414364A CN 202311633965 A CN202311633965 A CN 202311633965A CN 117414364 A CN117414364 A CN 117414364A
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- composition
- inositol
- capsule
- composition according
- preparation
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- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract description 44
- 230000003712 anti-aging effect Effects 0.000 title claims abstract description 10
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 23
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims abstract description 22
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims abstract description 12
- 229960000367 inositol Drugs 0.000 claims abstract description 12
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 11
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 claims abstract description 10
- 229930002877 anthocyanin Natural products 0.000 claims abstract description 10
- 239000004410 anthocyanin Substances 0.000 claims abstract description 10
- 235000010208 anthocyanin Nutrition 0.000 claims abstract description 10
- 150000004636 anthocyanins Chemical class 0.000 claims abstract description 10
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 9
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 9
- 239000002775 capsule Substances 0.000 claims description 26
- 241000196324 Embryophyta Species 0.000 claims description 9
- 238000009472 formulation Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 240000008042 Zea mays Species 0.000 claims description 5
- 229930003270 Vitamin B Natural products 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 4
- 230000036039 immunity Effects 0.000 claims description 4
- 235000019156 vitamin B Nutrition 0.000 claims description 4
- 239000011720 vitamin B Substances 0.000 claims description 4
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 3
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 3
- 230000003266 anti-allergic effect Effects 0.000 claims description 3
- 230000003078 antioxidant effect Effects 0.000 claims description 3
- 235000005822 corn Nutrition 0.000 claims description 3
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 235000006708 antioxidants Nutrition 0.000 claims description 2
- 230000002708 enhancing effect Effects 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 abstract description 4
- 230000032683 aging Effects 0.000 abstract description 4
- 230000036506 anxiety Effects 0.000 abstract description 4
- 230000004630 mental health Effects 0.000 abstract description 3
- 230000003647 oxidation Effects 0.000 abstract description 3
- 238000007254 oxidation reaction Methods 0.000 abstract description 3
- 230000005855 radiation Effects 0.000 abstract description 2
- 230000036541 health Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 4
- 241000282414 Homo sapiens Species 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- NSEWTSAADLNHNH-LSBOWGMISA-N proanthocyanidin A2 Chemical group C1([C@H]2OC3=C4[C@H]5C6=C(O)C=C(O)C=C6O[C@]([C@@H]5O)(OC4=CC(O)=C3C[C@H]2O)C=2C=C(O)C(O)=CC=2)=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-LSBOWGMISA-N 0.000 description 2
- 235000008160 pyridoxine Nutrition 0.000 description 2
- 239000011677 pyridoxine Substances 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 229920002982 Procyanidin A2 Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000009169 immunotherapy Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000011785 micronutrient Substances 0.000 description 1
- 235000013369 micronutrients Nutrition 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- NSEWTSAADLNHNH-UHFFFAOYSA-N pavetannin A-2 Natural products OC1CC2=C(O)C=C3OC(C4O)(C=5C=C(O)C(O)=CC=5)OC5=CC(O)=CC(O)=C5C4C3=C2OC1C1=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 238000011158 quantitative evaluation Methods 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
Abstract
The invention belongs to the field of health-care product preparation, and particularly relates to an anti-aging composition and related application thereof. The composition comprises anthocyanin, vitamin B6, myo-inositol and D-chiro-inositol. The components can effectively delay aging caused by oxidation and radiation, enhance pleasure, satisfy and relax feeling, improve acuity and energy, eliminate depression and anxiety feeling, criminal and failure feeling, and show the importance of the formula on mental health.
Description
Technical Field
The invention belongs to the field of health-care product preparation, and particularly relates to an anti-aging composition and related application thereof.
Background
The prior art provides an anti-aging health care product which has the defect of excessively complex ingredients, has an undefined health care effect due to complicated compatibility, and further contains a large amount of plants with indistinct ingredients or compounds which are unfavorable for large-scale intake. Meanwhile, in order to ensure long-time preservation and easy-to-take taste of the health care product, a large amount of auxiliary materials irrelevant to the health care function are mixed in the health care product, so that the health care product and the propaganda effect thereof are in a rare situation. The other health care products have unreasonable dosage forms, such as instant granules which are convenient to carry but have the problem that the temperature is difficult to control during brewing, so that the effective substances have defects in absorption, and the instant granules are inconvenient to take because of the need of preparing other appliances during taking; some tablets require the addition of extraneous excipients such as shaping agents for shaping purposes.
Disclosure of Invention
The invention aims to provide an anti-aging composition and related application thereof. The components of the anti-aging composition provided by the invention are obtained through repeated experiments, verification and selection by clinical experience in immunotherapy practice, have simple proportion and obvious effect, are not added with any assistance, and have excellent functions of improving immunity, resisting aging, resisting oxidation and the like.
The invention provides an anti-aging composition which comprises the following components: anthocyanin, vitamin B6, myo-inositol and D-chiro-inositol.
In the invention, the composition consists of the following components in parts by mass; 285-315 parts of anthocyanin, 628.5-31.5 parts of vitamin B, 1900-2100 parts of myo-inositol and 47.5-52.5 parts of D-chiro-inositol.
In the present invention, the dosage form of the composition includes a capsule.
In the present invention, when the formulation of the composition is a capsule, the capsule in the capsule is a plant capsule made of corn.
In the present invention, when the formulation of the composition is a capsule, each capsule contains 0.5 to 0.6g of the composition.
In the present invention, when the dosage form of the composition is a capsule, the frequency of taking the composition is twice a day, two granules at a time.
The invention also provides application of the composition in preparation of a preparation with the effect of improving immunity.
The invention also provides application of the composition in preparation of a preparation with an anti-allergic effect.
The invention also provides application of the composition in preparation of a preparation with an antioxidant effect.
The invention also provides application of the composition in preparation of a preparation for improving metabolism efficiency.
The raw materials and the auxiliary materials used in the invention are homologous to each other, all natural extracts and simple substances purified by the natural extracts are adopted, and the adopted plant capsule shells are pure corn products. The effective components only comprise four kinds of anthocyanin, vitamin B6, myo-inositol and D-chiro-inositol, and the auxiliary materials only select plant capsules, and no other auxiliary materials are added. The active ingredients and auxiliary materials have no toxic or side effect under the condition of safe dosage. And the experiment shows that the components have no adverse chemical reaction.
The main application of the anthocyanin in the invention is as follows: antioxidant, antiallergic, and radioprotective. Vitamin B6, myo-inositol and D-chiro-inositol in the formula of the invention all belong to vitamin B group elements. The vitamin B group is effective in alleviating anxiety. They not only participate in metabolism, provide energy, protect nerve cells, but also help to tranquilize nerves and relieve anxiety. The micronutrient in the formula has close relation with human aging and mental health, can delay aging caused by oxidation and radiation, can enhance pleasure, satisfy and relax feelings, improve acuity and vigor, eliminate depression and anxiety feelings, criminal and failure feelings, and shows importance for the mental health of human beings.
The above substances cannot be stored in vivo and need to be frequently supplemented, and the supplementing method is preferably small and multiple times. The capsule mode is adopted, so that accurate proportioning can be ensured. Unnecessary additional substances in the tablet mode are avoided, and the absorption defect of the granule caused by personal difference is also avoided. The plant capsule used in the invention is convenient for centralized delivery and slow release, and does not generate peculiar smell and discomfort in taking. Is convenient for assisting in taking and taking for a small amount of times.
Detailed Description
In the invention, the purchase information of anthocyanin is as follows (the following information is subjected to coding avoidance processing, and if related information needs to be further verified, the inventor can be contacted to obtain specific information):
the product name is Procyanidin A2; PHL83223; brand: supelco; CASNo.41743-41-3; manufacturer or supplier name Sigma-Aldrich (Shanghai) tracking Co.Ltd.509Renqing Road Zhangjiang High Tech East Park, pudong SHANGHIAI 201201 SHANGHIAI CHINA Sigma Aldrich (Shanghai) trade company, shanghai, new Pudong district Renshiku Jie No. 509 merck company, 64271 damm Shi Da, ttd country Phone: +49 (0) 61-2440.
In the present invention, purchasing information of vitamin B6 is as follows:
product name: vitamin B6, also known as pyridoxine, pyridoxine Empirical Formula (Hill Notification) C8H11NO3; product number P5669; brand: sigma; CAS No. 65-23-6; manufacturer or supplier name Sigma-Aldrich (Shanghai) tracking Co.Ltd.509Renqing RoadZhangjiang High Tech East Park, pudongSHANGHIAI 201201SHANGHAICHINA Sigma Aldrich (Shanghai) trade company, shanghai, pudong New zone Renshiu 509 merck company, 64271 damm Shi Da Ted country Phone: +49 (0) 61-2440.
In the present invention, the purchase information of myo-inositol is as follows:
product name: myo-Inositol; product number I5125; brand Sigma CAS No. 87-89-81.2; manufacturer or supplier name Sigma-Aldrich (Shanghai) tracking Co.Ltd.509Renqing Road Zhangjiang High Tech East Park, pudong SHANGHIAI 201201 SHANGHIAI CHINA Sigma Aldrich (Shanghai) trade company, shanghai, new Pudong district Renshiku Jie No. 509 merck company, 64271 damm Shi Da, ttd country Phone: +49 (0) 61-2440.
In the present invention, the purchase information of D-chiro-inositol is as follows:
product name: chiral Inositol D-chiro-inolitol; product number 74137; brand: sigma; CAS No. 643-12-91.2; manufacturer or supplier name Sigma-Aldrich (Shanghai) tracking Co.Ltd.509Renqing RoadZhangjiang High Tech East Park, pudongSHANGHIAI 201201SHANGHAICHINA Sigma Aldrich (Shanghai) trade company, shanghai, pudong New zone of Shanghai, calif. No. 509 merck stock company 64271 damm Shi Da Ted country Phone: +49 (0) 61-2440
In the present invention, purchase information of the plant capsule is as follows:
brand: kernel and heart craftsman; trade name: plant corn empty capsule shells; commodity number: 10070882808832; cargo number: q3.15142753; the production place: zhejiang Jinhua.
Examples
Main and auxiliary materials used for preparing the anti-aging composition capsule are as follows: anthocyanin, vitamin B6, myo-inositol, D-chiro-inositol and plant capsule (No. 0 plant corn empty capsule shell).
Anthocyanin, vitamin B6, myo-inositol and D-chiro-inositol are prepared according to the following mass ratio: 300:30:2000:50, and loading into No. 0 plant capsule each containing 595+ -30 mg of effective component.
The volunteer subjects (40 to 80 years old) were dosed twice daily, 2 granules each, for 30 days. The immunization quantitative evaluation was performed on 10 ml blood collected from 35 subjects on the baseline day. The 28 volunteers complete the test as required, and 10 ml of blood is collected again for quantitative immunization evaluation within one week after the end of taking. Immune quantification assessment commission Hangzhou Pu Luo Ting medical test Co., ltd (sample numbers: 161125006730 to 161125006793). Test results: the 19 human immunity quantitative index is obviously increased, which is about 67.8 percent. 9 people did not change significantly. Preliminary experiments prove that the formula is safe and effective.
Although the foregoing embodiments have been described in some, but not all, embodiments of the invention, it should be understood that other embodiments may be devised in accordance with the present embodiments without departing from the spirit and scope of the invention.
Claims (10)
1. An anti-aging composition, characterized in that the composition consists of: anthocyanin, vitamin B6, myo-inositol and D-chiro-inositol.
2. The composition according to claim 1, wherein the composition consists of the following components in parts by mass; 285-315 parts of anthocyanin, 628.5-31.5 parts of vitamin B, 1900-2100 parts of myo-inositol and 47.5-52.5 parts of D-chiro-inositol.
3. The composition of claim 1, wherein the dosage form of the composition comprises a capsule.
4. A composition according to claim 3, wherein when the composition is in the form of a capsule, the capsules in the capsule are corn-based plant capsules.
5. A composition according to claim 3, wherein when the composition is in the form of a capsule, each capsule contains 0.5 to 0.6g of the composition.
6. A composition according to claim 3, wherein when the composition is in the form of a capsule, the composition is taken twice daily, two granules at a time.
7. Use of a composition according to any one of claims 1 to 6 for the preparation of a formulation having an efficacy of enhancing immunity.
8. Use of a composition according to any one of claims 1 to 6 for the preparation of a formulation having anti-allergic efficacy.
9. Use of a composition according to any one of claims 1 to 6 for the preparation of a formulation having antioxidant efficacy.
10. Use of a composition according to any one of claims 1 to 6 for the preparation of a formulation having an increased metabolic efficiency.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202311633965.XA CN117414364A (en) | 2023-12-01 | 2023-12-01 | Anti-aging composition and related application thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202311633965.XA CN117414364A (en) | 2023-12-01 | 2023-12-01 | Anti-aging composition and related application thereof |
Publications (1)
Publication Number | Publication Date |
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CN117414364A true CN117414364A (en) | 2024-01-19 |
Family
ID=89525015
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN202311633965.XA Pending CN117414364A (en) | 2023-12-01 | 2023-12-01 | Anti-aging composition and related application thereof |
Country Status (1)
Country | Link |
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CN (1) | CN117414364A (en) |
-
2023
- 2023-12-01 CN CN202311633965.XA patent/CN117414364A/en active Pending
Non-Patent Citations (1)
Title |
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徐雅,杜庆红主编: "中西医结合执业医师资格考试医学综合通关全攻略 西综、人文分册", vol. 1, 31 December 2021, 中国中医药出版社, pages: 1369 - 1370 * |
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