CN117327580A - Metal organ chip for biomedical research - Google Patents
Metal organ chip for biomedical research Download PDFInfo
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- CN117327580A CN117327580A CN202311314427.4A CN202311314427A CN117327580A CN 117327580 A CN117327580 A CN 117327580A CN 202311314427 A CN202311314427 A CN 202311314427A CN 117327580 A CN117327580 A CN 117327580A
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- 229910052751 metal Inorganic materials 0.000 title claims abstract description 32
- 239000002184 metal Substances 0.000 title claims abstract description 32
- 210000000056 organ Anatomy 0.000 title claims abstract description 30
- 238000011160 research Methods 0.000 title claims abstract description 19
- 150000002739 metals Chemical class 0.000 claims abstract description 13
- 239000012530 fluid Substances 0.000 claims description 8
- 229910000861 Mg alloy Inorganic materials 0.000 claims description 5
- 239000000788 chromium alloy Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 4
- 230000006854 communication Effects 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 3
- 238000010146 3D printing Methods 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 229910001256 stainless steel alloy Inorganic materials 0.000 claims 1
- 239000007943 implant Substances 0.000 abstract description 31
- 210000002346 musculoskeletal system Anatomy 0.000 abstract description 10
- 230000004044 response Effects 0.000 abstract description 5
- 230000014509 gene expression Effects 0.000 abstract description 4
- 230000001225 therapeutic effect Effects 0.000 abstract description 4
- 230000006870 function Effects 0.000 abstract description 3
- 238000001727 in vivo Methods 0.000 abstract description 3
- 108090000623 proteins and genes Proteins 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 239000006177 biological buffer Substances 0.000 abstract description 2
- 230000032823 cell division Effects 0.000 abstract description 2
- 238000000576 coating method Methods 0.000 abstract description 2
- 230000004069 differentiation Effects 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 238000002474 experimental method Methods 0.000 abstract description 2
- 238000000338 in vitro Methods 0.000 abstract description 2
- 230000008611 intercellular interaction Effects 0.000 abstract description 2
- 238000005259 measurement Methods 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 230000035755 proliferation Effects 0.000 abstract description 2
- 102000004169 proteins and genes Human genes 0.000 abstract description 2
- 238000012216 screening Methods 0.000 abstract description 2
- 230000004083 survival effect Effects 0.000 abstract description 2
- 230000002110 toxicologic effect Effects 0.000 abstract description 2
- 231100000027 toxicology Toxicity 0.000 abstract description 2
- 239000002028 Biomass Substances 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 18
- 239000000463 material Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 230000001413 cellular effect Effects 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- 230000003993 interaction Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 230000012292 cell migration Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 230000035790 physiological processes and functions Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001185 bone marrow Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000008614 cellular interaction Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/02—Form or structure of the vessel
- C12M23/16—Microfluidic devices; Capillary tubes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
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Abstract
The metal organ chip for biomedical research at least comprises an organ chip unit; organ-chip said unit comprising at least one set of microfluidic channels for the flow of biomass or culture medium therein; and a viewing window disposed along the microfluidic channel; the organ-chip unit is fabricated from biocompatible metals. An organ chip for mimicking medical implants in the human musculoskeletal system incorporating living cells cultured in a microfluidic device mimicking tissue-implant interface, mechanical and chemical ring, electric and magnetic stimuli and organ level functions of the living organ, and allowing cells to be cultured in vitro under pharmacological conditions similar to those in vivo for studying conditions including cell-cell interactions, cell division, proliferation, differentiation, survival, liquation , cell substitution, shear force response, gene expression, protein expression, and the like. By covering the organ-in-chip with a biological or therapeutic coating, either immersed in a biological buffer, or containing drug release microstructures, the natural state of the cells under the action of the metal is simulated, providing predictive value for screening, toxicological experiments, and efficacy measurements.
Description
Technical Field
The invention relates to a metal organ chip for biomedical research.
Background
Drug discovery and development are complex procedures requiring complex experimentation to evaluate efficacy and safety through preclinical studies.
Organ Chip (OoC) is also called micro-physiological system (MPS) and is a cell culture system simulating active physiological environment, reproducing tissue-tissue interface and simulating multiple biological reactions. Current organ-chips consist of microfluidic channels (microfluidic channels/microchannels) and micro-chambers (microcavities) allowing for the cultivation of one or more cell types with small amounts of solution. Due to their 3D nature and complex microfluidic structures, organ-chips are better than 2D in vitro experiments performed on petri dishes and are becoming increasingly popular in pharmaceutical and medical research to study interactions between natural tissues and cells and characterize preclinical studies of pharmaceutical chemistry. However, since current organ-chips are made of silicon or glass, thermosetting materials or other organic materials, their use in studying the effect of other therapeutic materials such as metals on cells is limited.
Disclosure of Invention
The embodiment of the invention aims to provide a metal organ chip for biomedical research, which provides an economic and efficient, ethical, reproducible and accurate platform for preclinical research and biotechnology research, and is particularly used for researching the interaction between a medical metal implant designed for a skeletal muscle system of a musculoskeletal system and somatic cells, biological tissues, biological reagents and the like.
The invention is realized by the following technical scheme:
a metal organ chip for biomedical research,
at least comprises an organ chip unit;
the organ-on-chip unit is formed from at least one set of microfluidic channels for the flow of biological cell fluids therein;
and a viewing window disposed along the microfluidic channel;
the organ-chip unit is fabricated from biocompatible metals.
Preferably, the microfluidic channel is provided with a plurality of branch channels, at least adjacent branch channels being in communication with each other.
Preferably, the microfluidic channel is composed of a plurality of parallel channels with the same or different inner diameters, and communication holes are formed in the side walls of the parallel channels.
Preferably, the observation window extends radially along the wall of the microfluidic channel, the observation window is provided with an observation hole communicated with the microfluidic channel, and the observation hole is provided with a light-transmitting cover plate or a film to cover and seal the observation hole.
Preferably, the organ-chip is connected by a plurality of organ-chip units in accordance with a microbial system structure, and microfluidic channels between the organ-chip units communicate.
Preferably, the compatible metals include titanium alloys, cobalt chromium alloys, stainless steel, magnesium alloys, and other metals useful in biomedical applications.
Preferably, the organ-chip unit is formed by three-dimensional printing using compatible metals.
Compared with the prior art, the invention has the beneficial effects that: organ chip for mimicking medical implants in the human musculoskeletal system, the device incorporating living cells cultured in a microfluidic device, mimicking tissue-implant interfaces, mechanical and chemical environment, electrical and magnetic stimuli, and organ level functions of living organs, such as static skeletal, movable and immovable joints, contracting muscles, self-renewing bone marrow. On the other hand, organ-chips allow cells to be cultured in vitro under pharmacological conditions similar to those in vivo for studies involving cell-cell interaction responses, cell division, proliferation, differentiation, survival status, cellular metabolic activity, shear stress, gene expression, gene and protein expression, and the like. The natural state of cells under the action of metal is simulated by covering biological or therapeutic coatings in an organ chip or immersing the organ chip in biological buffer, so that the predictive value is provided for screening, toxicological experiments and efficacy measurement.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings that are required to be used in the technical description of the embodiments will be described below.
FIG. 1 is a perspective view of a first embodiment of the present invention;
FIG. 2 is a schematic diagram of a first embodiment of a microfluidic channel according to the present invention;
FIG. 3 is a schematic diagram of a second embodiment of a microfluidic channel according to the present invention;
FIG. 4 is a schematic view of a third embodiment of a microfluidic channel according to the present invention;
FIG. 5 is a cross-sectional view of a second embodiment of the present invention;
FIG. 6 is a cross-sectional view of a third embodiment of the invention;
fig. 7 is a front view of a fourth embodiment of the present invention.
Description of the embodiments
Referring to fig. 1-3, the present invention includes multiple versions and may be used in a variety of applications. In one embodiment, the organ-chip is a simple chip composed of wells of different diameters, which enables cell migration based on various applications. The organ chip is intended to imitate the musculoskeletal system, and is mainly applied to research of body cells and non-body cells, and is mainly used for research of interactions between body cells in the musculoskeletal system and medical metal implants specially designed for the musculoskeletal system. It can also be used to study the behavior of cells in a controlled environment and to study the effect of different parameters on cell migration.
The metal organ chip at least comprises an organ chip unit (1); the organ-chip unit (1) is formed by at least one group of microfluidic channels (2) for the flow of biological cell fluids therein; and a viewing window (3) arranged along the microfluidic channel (2); the organ-chip unit (1) is manufactured from a biocompatible metal.
In another embodiment, the microfluidic channel (2) is composed of a plurality of parallel channels with the same or different inner diameters, and the side walls of the parallel channels are provided with communication holes so as to imitate different organs to form flow channels with different diameters, and fluid between the different channels can realize substance exchange through micropore permeation, and the flow channels refer to fig. 5 and 6.
In another embodiment, the invention is an organ-chip comprising at least one porous scaffold or chamber in the chip, one or more microfluidic inlets and one or more microfluidic outlets, wherein the outlets are connected to the scaffold. The geometry of the scaffold and chamber is designed to provide cellular interactions, fluid flow, pressure, and related physiological parameters related to those of the cells, tissues or organs in the respective body. The organ-chip includes a fluidic network of channels that are separated into discrete but interconnected chambers, allowing unidirectional or cyclic fluid flow.
The invention comprises a plurality of discrete but interconnected organ-chip units (1) which can be connected and separated by connection interfaces to form a complex network. The medium may be constituted by two or more connected chips and the biological cell fluid flows from one chip unit to the other. Different media may also be provided like individual cells, see fig. 7.
The micro-fluidic channels (2), chambers, scaffolds, valves, etc. form complex micro-channel networks, such as hexagonal networks, spiral helices, branched tubular networks, and triangular meshes, so that the direction of flow of the biological medium can be guided, or the morphology of the implant can be simulated, or the physiological structure can be simulated.
The biocompatible metals, including titanium, cobalt-chromium alloys, stainless steel, magnesium alloys, and the like, are common materials for medical implants. For example, pacemakers are mostly made of titanium alloys and contain traces of other metals such as manganese, nickel, iron, etc. Magnesium alloys, cobalt chromium alloys and stainless steel are widely used in orthopedic implants. Thus, the therapeutic efficacy and safety of these implants were investigated by in vivo animal tests. Nevertheless, animal research is expensive and time consuming due to the high maintenance costs and slow growth rate of animals, and ethical issues are often a concern. Furthermore, animal studies often suffer from inaccuracy due to fundamental physiological differences between model organisms and humans, as well as intra-species variability. Here, we provide a metal organ chip that provides a low cost, high efficiency, high throughput, ethical, reproducible and accurate platform for preclinical and biotechnology studies.
Metal organ-chip is not only a highly complex platform for studying complex physiological processes, but also provides significant cost savings for the development of biomedical implants and therapies. Compared with the traditional method, the device has lower manufacturing cost and higher experimental efficiency, thereby reducing the research and development cost of the orthopedic implant and the medicine.
The metal organ chip can imitate the micro-architecture and functions of living human organs and tissues such as musculoskeletal system, and has no ethical problems related to animal testing, which is a key advantage. The device can more accurately simulate the human musculoskeletal system, reduce the need for animal testing, and provide more reliable results.
The metal organ-a-chip is made of medical grade metals including CoCrMo alloys (ASTM F75), ti6AI4V (ASTM F136), SS316L (ASTM F138), magnesium alloys, and the like. These metals have been used in medical implants for decades and have proven to be biocompatible and safe for medical applications. It provides a highly innovative and cost-effective platform for studying complex physiological processes and developing safer, more effective biomedical implants and therapies. The device is capable of mimicking the musculoskeletal system without concern for ethical issues, and can replace animal testing to a large extent, which is a significant advantage, and the use of medical grade metals ensures the safety and reliability of the device in medical applications. The device can save the cost remarkably, and becomes a precious tool for developing the next generation biomedical implant and innovating medical instruments and therapies.
The present invention has many benefits in the biomedical implant industry, including but not limited to testing implant materials, studying implant-host interactions, developing personalized implants, and testing implant performance. The invention incorporates metallic components that can be used to test the biocompatibility of materials used in biomedical implants.
By simulating the musculoskeletal system and the cellular environment surrounding the implant, researchers can study the effects of different materials on cellular behavior and determine the most appropriate material for the implant. Also, the device may be used to study interactions between implant materials and host tissue. By mimicking the cellular environment surrounding the implant, researchers can measure the response of host cells to the implant and identify potential problems such as inflammation or immune responses.
Furthermore, the integrated metal organ-chip device may be used to develop personalized implants tailored to individual specific physiological conditions. By simulating the cellular environment surrounding the implant and measuring the response of the cells, researchers can determine the most appropriate implant materials and designs, thereby minimizing adverse reactions and maximizing effectiveness.
The apparatus may also be used to test the performance of biomedical implants in a controlled environment. By simulating the cellular environment surrounding the implant and incorporating metal electrodes or sensors, researchers can measure the response of cells and tissues to the implant and identify potential problems such as mechanical failure or performance deficiencies.
Claims (7)
1. A metallic organ-chip for biomedical research, characterized by:
at least comprises an organ chip unit (1);
the organ-chip unit (1) is formed by at least one group of microfluidic channels (2) for the flow or culture of biological media therein;
and a viewing window (3) arranged along the microfluidic channel (2);
the organ-chip unit (1) is manufactured from a biocompatible metal.
2. The metal-made organ-chip for biomedical research of claim 1, wherein: the microfluidic channel (2) is provided with a plurality of branch channels, and at least two adjacent branch channels are communicated.
3. The metal-made organ-chip for biomedical research of claim 1, wherein: the microfluidic channel (2) is internally composed of a plurality of parallel channels with the same or different inner diameters, and communication holes are formed in the side walls of the parallel channels.
4. The metal-made organ-chip for biomedical research of claim 1, wherein: the observation window (3) radially extends along the wall of the micro-fluid channel (2), the observation window (3) is provided with an observation hole communicated with the micro-fluid channel (2), and the observation hole is provided with a light-transmitting cover plate or a film to cover and seal the observation hole.
5. The metal-made organ-chip for biomedical research of claim 1, wherein: the organ chip is connected by a plurality of organ chip units (1) according to a microbial system structure, and microfluidic channels (2) between the organ chip units (1) are communicated.
6. The metal-made organ-chip for biomedical research of claim 1, wherein: the compatible metals include titanium alloys, cobalt chromium alloys, stainless steel, and magnesium alloys.
7. The metal-made organ-chip for biomedical research of claim 1, wherein: the organ chip unit (1) is formed by three-dimensional printing by adopting compatible metals.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HK32022063794 | 2022-11-14 | ||
| HK32022063794.8 | 2022-11-14 |
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| Publication Number | Publication Date |
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| CN117327580A true CN117327580A (en) | 2024-01-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202311314427.4A Pending CN117327580A (en) | 2022-11-14 | 2023-10-11 | Metal organ chip for biomedical research |
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| Country | Link |
|---|---|
| CN (1) | CN117327580A (en) |
| WO (1) | WO2024105481A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024105481A1 (en) * | 2022-11-14 | 2024-05-23 | 香港科能有限公司 | Metal organ-on-a-chip for biomedical research |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN209123963U (en) * | 2018-10-10 | 2019-07-19 | 武汉介观生物科技有限责任公司 | A kind of fixture encapsulating micro-fluid chip |
| CN112280678B (en) * | 2020-12-25 | 2021-04-06 | 苏州大学 | Detachable and reusable hydrophobic or super-hydrophobic microfluidic organ chip |
| CN114939446A (en) * | 2022-05-05 | 2022-08-26 | 大连理工大学 | Microfluidic chip for co-culturing multiple cells by parallel channel micro-fences and application thereof |
| CN115109703A (en) * | 2022-08-04 | 2022-09-27 | 上海生物芯片有限公司 | Organ chip model |
| CN117327580A (en) * | 2022-11-14 | 2024-01-02 | 香港科能有限公司 | Metal organ chip for biomedical research |
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2023
- 2023-10-11 CN CN202311314427.4A patent/CN117327580A/en active Pending
- 2023-10-30 WO PCT/IB2023/060890 patent/WO2024105481A1/en unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024105481A1 (en) * | 2022-11-14 | 2024-05-23 | 香港科能有限公司 | Metal organ-on-a-chip for biomedical research |
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