CN117224816A - Pressure guide wire based on flexible piezoelectric sensor - Google Patents
Pressure guide wire based on flexible piezoelectric sensor Download PDFInfo
- Publication number
- CN117224816A CN117224816A CN202310817337.0A CN202310817337A CN117224816A CN 117224816 A CN117224816 A CN 117224816A CN 202310817337 A CN202310817337 A CN 202310817337A CN 117224816 A CN117224816 A CN 117224816A
- Authority
- CN
- China
- Prior art keywords
- guide wire
- sensor
- piezoelectric
- circuit
- piezoelectric sensor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002033 PVDF binder Substances 0.000 claims abstract description 31
- 229920002981 polyvinylidene fluoride Polymers 0.000 claims abstract description 31
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 15
- 239000007787 solid Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 5
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- 229910001220 stainless steel Inorganic materials 0.000 claims description 8
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 6
- 239000010935 stainless steel Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 239000000741 silica gel Substances 0.000 claims description 4
- 229910002027 silica gel Inorganic materials 0.000 claims description 4
- 239000011248 coating agent Substances 0.000 claims description 3
- 238000000576 coating method Methods 0.000 claims description 3
- 238000009713 electroplating Methods 0.000 claims description 3
- 239000000499 gel Substances 0.000 claims description 2
- 238000003466 welding Methods 0.000 claims description 2
- 238000004804 winding Methods 0.000 claims description 2
- 239000010410 layer Substances 0.000 claims 18
- 229910004353 Ti-Cu Inorganic materials 0.000 claims 3
- 239000007772 electrode material Substances 0.000 claims 2
- 238000003491 array Methods 0.000 claims 1
- 238000001755 magnetron sputter deposition Methods 0.000 claims 1
- 229920002120 photoresistant polymer Polymers 0.000 claims 1
- 229920001296 polysiloxane Polymers 0.000 claims 1
- 239000011241 protective layer Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 238000005259 measurement Methods 0.000 abstract description 11
- 230000017531 blood circulation Effects 0.000 abstract description 6
- 230000036772 blood pressure Effects 0.000 abstract description 3
- 201000000057 Coronary Stenosis Diseases 0.000 description 7
- 206010011089 Coronary artery stenosis Diseases 0.000 description 6
- 210000004351 coronary vessel Anatomy 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 4
- 229910052709 silver Inorganic materials 0.000 description 4
- 239000004332 silver Substances 0.000 description 4
- IUYOGGFTLHZHEG-UHFFFAOYSA-N copper titanium Chemical compound [Ti].[Cu] IUYOGGFTLHZHEG-UHFFFAOYSA-N 0.000 description 3
- 230000003902 lesion Effects 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000035762 Disorder of lipid metabolism Diseases 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 238000012995 silicone-based technology Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
Landscapes
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
Abstract
The invention provides a pressure guide wire based on a flexible piezoelectric sensor, wherein the main body of the pressure guide wire is of a solid structure, a film type PVDF piezoelectric sensor array with a large length-width ratio characteristic is spirally wound on the main body of the guide wire to form the pressure guide wire, the head of the pressure guide wire is of a spring-shaped spiral structure with one end welded with a smooth semi-solid ball head, 6 piezoelectric sensor electrodes and electrode circuits are arranged on the surface of the pressure guide wire, the electrode circuits on the surface of the pressure guide wire are directly prepared on the upper surface of a piezoelectric film, and all the electrode circuits on the surface of the pressure guide wire can be connected with an external acquisition circuit, so that blood flow pressure signals of 6 positions in a blood vessel, which are measured by 6 piezoelectric sensors, can be acquired in real time. The invention solves the problems that the traditional pressure guide wire has insufficient softness and only has one pressure sensor, and the pressure guide wire is pushed and pulled back and forth in a blood vessel in the measurement process to finish the measurement of the multipoint blood pressure, thereby greatly increasing the risk of the operation and simultaneously reducing the measurement accuracy.
Description
Technical Field
The invention relates to a pressure guide wire, in particular to a flexible piezoelectric sensor-based pressure guide wire which is inserted into a coronary artery of a patient and used for measuring blood flow pressure at different points in a lesion blood vessel.
Technical Field
The aging of the population has become more serious since the 21 st century, and cardiovascular system type diseases plagued the middle aged and the elderly of the current generation, and as a common cardiovascular chronic disease, coronary arteries have become narrower and narrower (hereinafter abbreviated as coronary artery stenosis) with the increase of time due to disorder of lipid metabolism in the body and adhesion of lipid to the vessel wall. The main clinical method for diagnosing coronary artery stenosis is to carry out coronary artery radiography, but the angiography technology can not carry out effective detection on long lesion blood vessels, so the main current coronary artery stenosis detection method is to insert a flexible guide wire (hereinafter referred to as a pressure guide wire) integrated with a pressure sensor into the blood vessel of the coronary artery stenosis, and the position formed by the coronary artery stenosis is judged by measuring blood flow pressure values at different positions in the blood vessel, so that a doctor can conveniently and accurately grasp the internal condition of the blood vessel.
The diameter of a pressure guide wire for measuring coronary artery stenosis, which is clinically used at present, is 0.73mm, the length is about 28cm, a sensor above the pressure guide wire is mainly prepared by adopting a silicon-based technology, and the pressure guide wire has the following defects:
1. only a single pressure sensor is arranged on the guide wire, and the guide wire needs to be moved back and forth when blood pressure is measured, so that the operation risk is increased;
2. the rigid substrate of the pressure sensor on the guide wire is such that when it is integrated in an array on the guide wire, the guide wire will not meet the softness requirement for movement within the coronary artery.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a pressure guide wire based on a flexible piezoelectric sensor, which solves the problems of insufficient measurement points and insufficient softness of the conventional pressure guide wire.
The invention provides a pressure guide wire based on a flexible piezoelectric sensor, wherein the pressure guide wire main body is of a solid structure, a wire guiding head part is of a spring-shaped spiral structure, one end of the spring-shaped spiral structure is welded with a smooth semi-solid ball head, 6 piezoelectric sensors are arranged on the surface of the guide wire, and blood pressure measurement of different positions in a blood vessel can be realized by inserting the pressure guide wire into the blood vessel and matching with an external circuit; the piezoelectric sensor electrode and the electrode circuit on the surface of the pressure guide wire are directly prepared on the piezoelectric film, the lower surface circuit is the guide wire, the upper surface circuit and the lower surface circuit are connected with an external acquisition circuit, and the PVDF piezoelectric film after the sensor electrode and the circuit are prepared has a larger length-width ratio, so that the PVDF piezoelectric film can be better spirally wound on the guide wire main body.
The piezoelectric film has the characteristic of full flexibility, so that the flexible piezoelectric sensor prepared based on the piezoelectric film is spirally wound on the surface of the guide wire, and the fixed connection between the guide wire and the flexible piezoelectric sensor is realized through the conductive silver adhesive, so that the integration of a plurality of flexible piezoelectric sensors on the surface of the guide wire is realized, the problem that the size of the flexible piezoelectric sensor cannot be too large due to the too thin guide wire is avoided, the number and the size of the piezoelectric sensors are increased, the measurement point positions are increased, and the problem of insufficient measurement point positions is solved. The manufacturing difficulty and the manufacturing cost are reduced.
In the invention, the pressure sensor sensitive layer adopts a commercial flexible PVDF piezoelectric film, piezoelectric sensor electrodes and wires are directly manufactured on the upper surface of the PVDF piezoelectric film to be used as an upper circuit of a piezoelectric sensor array, the electrodes and wires are made of titanium copper metal layers, and the pressure sensor sensitive layer is prepared by adopting a magnetron sputtering-photoetching-electroplating process; the lower electrode of the piezoelectric sensor array is a guide wire, a medical grade stainless steel wire with the diameter of 0.73mm is adopted, silver colloid is used for bonding the lower electrode with the lower surface of the PVDF piezoelectric film after the electrode is prepared, and the guide wire body is packaged by adopting medical grade transparent silica gel after the sensor is integrated.
In the invention, piezoelectric sensors are designed into a 6 multiplied by 1 linear array structure, namely 6 piezoelectric sensing electrodes and leads are firstly prepared on the upper surface of a PVDF piezoelectric film, a lower circuit, namely a ground electrode circuit, is a guide wire, and the ground electrodes of each piezoelectric sensor are connected in series; the size of each piezoelectric sensor on the PVDF piezoelectric film depends on the electrode size of the upper circuit, so that the size of each piezoelectric sensor can be controlled only by controlling the electrode size of the upper circuit, thereby simplifying the preparation process; because of adopting a linear array structure, a plurality of piezoelectric sensors can be prepared, so that the pressure guide wire can simultaneously measure the blood flow pressure of multiple points in a blood vessel; the thickness of the circuit electrode on the piezoelectric sensor is only 6 mu m, so that the influence on the flexibility of the whole piezoelectric sensor array is negligible. The distance between circuit electrodes on the flexible piezoelectric sensor is 15mm.
According to the invention, the pressure guide wire is provided with the plurality of micro piezoelectric sensors in a winding way, the micro piezoelectric sensors are distributed along the surface of the guide wire in a multi-point way, the pressure values of the multi-point points can be measured simultaneously, the effect of measuring the multi-point pressure is exerted in the interventional treatment process, and the blood flow pressure at each point which is distributed in the coronary artery at equal intervals can be measured once, so that the operation risk caused by multiple times of measurement is avoided.
In the invention, the piezoelectric sensor array and the guide wire are wound and fixed by coating conductive silver gel, and the outer layer is coated with medical transparent silica gel to fill the gap and encapsulate the sensor.
In the invention, the pressure guide wire head is designed into a spiral spring structure, the inner diameter of the spring is slightly smaller than the diameter of the guide wire core, so that the pressure guide wire can be reliably fixed at the guide wire head, one section of the spring is welded with a semi-solid ball head, the resistance of the pressure guide wire when passing through a blood vessel is reduced, and the damage of the guide wire head to the inner wall of the blood vessel is reduced.
In the invention, the pressure guide wire core is made of medical grade stainless steel filaments, on one hand, the pressure guide wire core is used as a guide wire main body, on the other hand, the pressure guide wire core is used as a ground electrode circuit of a piezoelectric sensor, the total length of the pressure guide wire is 100mm, and the effective working area is 75mm; the total length of the spring structure of the pressure guide wire head is 1cm, and the fixedly connected length of the spring structure and the wire core is 5mm.
Compared with the prior art, the invention has the following beneficial effects:
the invention mainly solves the problems of insufficient flexibility, low measurement precision and need of multiple measurement of the existing pressure guide wire; by installing a plurality of piezoelectric sensors on the pressure guide wire, the blood flow pressure signals of a plurality of points in the axial direction of the blood vessel can be measured at one time, and measurement errors and operation risks caused by multiple times of measurement are avoided; the piezoelectric sensor array adopts the flexible piezoelectric film as the sensitive layer, so the piezoelectric sensor array can be well integrated with the guide wire, and the characteristic of sufficient surface area of the guide wire is effectively utilized, so the size of the integrated piezoelectric sensor is not too small, and the manufacturing difficulty and the production cost are reduced.
Drawings
Other features, objects, and advantages of the present invention will become more apparent upon reading the following detailed description of the device, taken in conjunction with the accompanying drawings.
Fig. 1 is a schematic overall structure of the present invention, and it is noted that, because the guide wire structure of the present invention is long, only a part of the drawing is cut out for illustration, and the rest of the non-cut-out parts will be illustrated in the specific embodiment, which is also within the protection scope of the present patent.
Detailed Description
The invention will now be described in detail with reference to the drawings and examples.
The invention provides a flexible piezoelectric sensor-based pressure guide wire for diagnosing coronary stenosis, and the following detailed description of specific embodiments of the invention is provided:
a pressure guide wire based on a flexible piezoelectric sensor comprises a semi-solid ball head 1, a spring 2, a PVDF piezoelectric film 3, a guide wire main body 4, a sensor circuit 5, a sensor circuit 6, a sensor circuit 7, a terminal electrode 8 of the sensor circuit, a sensor circuit 9, a sensor circuit 10 and a sensor circuit 11, wherein the terminal of each sensor circuit is connected with a sensor electrode, and the shape of each sensor electrode is the same as that of the terminal electrode 8 of the sensor circuit.
As shown in the drawings, the invention provides a pressure guide wire based on flexible piezoelectric sensors, 6 piezoelectric sensors are arranged on the surface of a guide wire main body 4, and the guide wire is inserted into a lesion blood vessel to measure intravascular multipoint blood pressure. In the figure, a semi-solid ball head 1 is fixedly connected with a spring 2, the spring 2 is fixedly connected with a guide wire main body 4, a PVDF piezoelectric film 3 is spirally wound and clung to the guide wire main body 4, sensor circuits 5, 6, 7, 8, 9, 10 and 11 are respectively connected with sensor electrodes 5, 6, 7, 8, 9, 10 and 11, the sensor circuits and the sensor electrodes 5-11 are prepared on the PVDF piezoelectric film by adopting a flexible electronic preparation process, and the sensor circuits 5-11, the sensor electrodes 5-11, the PVDF piezoelectric film 3 and the guide wire main body 4 respectively form upper electrode circuits, sensitive layers and ground electrode electrodes of 6 independent piezoelectric sensors integrated on the guide wire.
The key part of the guide wire is a PVDF piezoelectric film 3 wound on the surface, 6 sensor electrodes and sensor circuits 5-11 are prepared on the surface of the film through a flexible electronic preparation process and other modes, the lower surface of the PVDF piezoelectric film 3 is spirally bound on a guide wire main body 4 by adopting conductive silver paste, and the 6 sensors on the surface of the guide wire are connected by a common ground electrode, wherein the guide wire main body 4 is the ground electrode of the 6 piezoelectric sensors.
The top of the guide wire main body 4 is fixedly provided with a spring 2, the inner diameter of the spring is slightly smaller than 0.73mm, so that the spring can be fastened at the top of the guide wire main body 4, the top of the spring 2 is fixedly provided with a semi-solid ball head 1, the lower part of the ball head slightly stretches out to be conveniently fixedly connected at the top of the spring, meanwhile, in order to ensure the connection reliability, the semi-solid ball head 1 is fixedly connected with the spring 2 and then is fixed in a welding mode, and the spring 2 is fixedly connected with the guide wire main body 4 and then is welded.
The semi-solid ball head 1, the spring 2 and the guide wire main body 4 are made of medical grade stainless steel materials, the sensor circuit and the sensor electrodes 5-11 are copper titanium metal thin layers, the thickness of the copper titanium thin layers is about 6 mu m, the PVDF piezoelectric film 3 is a commercial finished film, the thickness of the PVDF piezoelectric film is 25 mu m, and the specially-made conductive silver adhesive is uniformly smeared below the PVDF piezoelectric film 3 after the electrodes are prepared and spirally coated on the guide wire main body 4, wherein the spiral angle of the PVDF piezoelectric film is 15 degrees.
The diameter of the guide wire main body 4 is 0.73mm, the overall maximum diameter of the pressure guide wire after integrating the sensors is 0.792mm, the length of the working area is 75mm, and the distance between every two sensors is 15mm.
In order to ensure the use safety of the guide wire, medical transparent silica gel is attached to the surface of the guide wire after the spiral coating is completed so as to isolate the device from the working environment.
While the pressure guidewire of the present invention has been described in detail above, it should be noted that the shape of the piezoelectric sensor electrode employed in the present invention is not limited to the form presented in the drawings, and that various modifications or adaptations may be made by the inventors within the scope of the claims without affecting the essential content of the present invention.
Claims (10)
1. A flexible piezoelectric sensor-based pressure guidewire, comprising: a semi-solid ball head [1], a spring [2], a PVDF piezoelectric film [3], a guide wire body [4], a sensor circuit [5], a sensor circuit [6], a sensor circuit [7], a terminal electrode of the sensor circuit [8], a sensor circuit [9], a sensor circuit [10], a sensor circuit [11]; the piezoelectric sensor is characterized in that the flexible piezoelectric sensor sensitive layer is a flexible PVDF piezoelectric film, the piezoelectric sensor prepared based on the material has the characteristic of full flexibility, the piezoelectric sensor adopts an upper layer structure, a middle layer structure and a lower layer structure, the upper layer structure is a metal circuit layer, the middle layer structure is a PVDF piezoelectric film, the lower layer structure is a guide wire, the piezoelectric film has insulativity, charges are generated at a pressed part of the piezoelectric film, a sensor upper circuit can be formed by preparing a sensor electrode and a circuit on the upper surface of the piezoelectric film, and the size of each piezoelectric sensor integrated on the guide wire can be controlled by controlling the size of the electrode of the upper circuit. The flexible piezoelectric sensor includes: piezoelectric sensor electrode and circuit array, PVDF piezoelectric film, seal wire main part, piezoelectric sensor electrode and circuit array include piezoelectric sensor circuit and terminal electrode of 6×1 arrays, each sensor electrode mutual distance 15mm.
2. The pressure guide wire based on the flexible piezoelectric sensor according to claim 1, wherein the pressure guide wire main body is of a solid structure, the wire guiding head is of a spring-shaped spiral structure with one end welded with a semi-solid ball head, and 6 piezoelectric sensors are arranged on the surface of the guide wire; the piezoelectric sensor circuit and the terminal electrode on the surface of the pressure guide wire are directly prepared on the PVDF piezoelectric film, the lower surface circuit of the piezoelectric sensor is the guide wire, and the upper surface circuit and the lower surface circuit of the piezoelectric sensor can be connected with an external acquisition circuit.
3. The flexible piezoelectric sensor-based pressure guide wire according to claim 2, wherein the piezoelectric sensor upper circuit structure is manufactured on the PVDF piezoelectric film in a magnetron sputtering-photoetching-electroplating mode, a Ti-Cu metal layer is selected as a material, photoresist is used as a sacrificial layer, the Ti-Cu metal layer is patterned and then used as an upper electrode material of the piezoelectric sensor, and different sensitivities of the sensor are realized by controlling the size of the sensor electrode prepared by magnetron sputtering-photoetching-electroplating; the middle layer structure is made of commercial flexible PVDF piezoelectric film material; the lower structure is a guide wire, a medical grade stainless steel wire is selected as a lower electrode material of the piezoelectric sensor, medical grade transparent silica gel is adopted as a protective layer for protecting an upper electrode circuit of the piezoelectric sensor, and a PVDF piezoelectric film after electrode preparation is covered on the surface of the guide wire in a spiral winding mode.
4. The flexible piezoelectric sensor-based pressure guidewire of claim 2, wherein the PVDF piezoelectric film is a commercially available finished film having a thickness of 25 μm.
5. The flexible piezoelectric transducer-based pressure guide wire of claim 3, wherein the Ti-Cu metal layer is prepared by a magnetron sputtering process, wherein the Ti layer is about 50nm thick and the Cu layer is about 200nm thick, and the Ti metal layer is sputtered first and then the Cu metal layer is sputtered on the PVDF piezoelectric film.
6. The flexible piezoelectric transducer-based pressure guidewire of claim 1, wherein the piezoelectric transducer ground electrode circuit is the guidewire itself, and conductive silver paste is used as a conductive medium between the sensor lower surface and the guidewire when the transducer is spirally wound.
7. The flexible piezoelectric sensor-based pressure guidewire of claim 1, wherein the guidewire body is a medical grade stainless steel filament having a diameter of 0.73mm and a length of 10cm; the semi-solid ball head is 0.73mm in diameter and is made of medical grade stainless steel; the length of the spring is 1cm, the outer diameter of the spring is 0.73mm, the inner diameter of the spring is 0.7mm, and the spring is made of medical grade stainless steel.
8. The flexible piezoelectric transducer-based pressure guidewire of any one of claims 1-7, wherein the piezoelectric transducer array is spirally coated on the surface of the guidewire with a helix angle of 15 °, and the flexible piezoelectric transducer array is encapsulated with a medical grade transparent silicone gel after spiral coating.
9. The pressure guide wire based on the flexible piezoelectric sensor according to claim 1, wherein the flexible piezoelectric sensor sensitive layer is a PVDF piezoelectric film, sensor electrodes and circuits are directly prepared on the upper surface of the PVDF piezoelectric film through a flexible electronic preparation process, the PVDF piezoelectric film of the prepared electrodes is cut into single devices with large length-width ratio, and the single devices are spirally coated on the surface of the guide wire.
10. The pressure guide wire based on the flexible piezoelectric sensor according to claim 1, wherein the guide wire main body is made of medical grade stainless steel filaments, the guide wire head is sleeved with a spiral spring, the inner diameter of the spring is slightly smaller than the diameter of the metal wires, so that the spring can be reliably fixed and welded on the guide wire head, and the other end of the spiral spring is fixed with a semi-solid ball head in a welding mode so as to protect the inner wall of a blood vessel.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310817337.0A CN117224816A (en) | 2023-07-04 | 2023-07-04 | Pressure guide wire based on flexible piezoelectric sensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310817337.0A CN117224816A (en) | 2023-07-04 | 2023-07-04 | Pressure guide wire based on flexible piezoelectric sensor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117224816A true CN117224816A (en) | 2023-12-15 |
Family
ID=89097395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310817337.0A Pending CN117224816A (en) | 2023-07-04 | 2023-07-04 | Pressure guide wire based on flexible piezoelectric sensor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117224816A (en) |
-
2023
- 2023-07-04 CN CN202310817337.0A patent/CN117224816A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103720463B (en) | Based on intelligent pressure seal wire and the transducer production method of flexible MEMS sensor | |
| AU2009212972B2 (en) | Force-sensing catheter with bonded center strut | |
| US20190133462A1 (en) | Pressure-sensing intravascular devices, systems, and methods | |
| US10329145B2 (en) | Capacitive intravascular pressure-sensing devices and associated systems and methods | |
| US4497324A (en) | Temperature monitoring catheter | |
| US6926674B2 (en) | Combined pressure-volume sensor and guide wire assembly | |
| CN103997954A (en) | Apparatus, system and methods for measuring a blood pressure gradient | |
| US20070255145A1 (en) | Sensor and guide wire assembly | |
| CN117224816A (en) | Pressure guide wire based on flexible piezoelectric sensor | |
| JP3420632B2 (en) | Multi-electrode probe | |
| EP2934309B1 (en) | Pressure-sensing intravascular device | |
| CN112353484B (en) | Flexible microsensor system, extensible flexible device and preparation method | |
| EP2590552B1 (en) | Sensor element with an insulation layer | |
| CN215584120U (en) | Pressure sensor and pressure sensing catheter, detection catheter for measuring diaphragm signals | |
| US20220133235A1 (en) | Sensor having an adapted housing | |
| EP3921876B1 (en) | Sensor comprising an interconnect having a carrier film | |
| JPH06142031A (en) | Medical care tool to be inserted in body and provided with detecting function for amount of self deformation and tactile sense function | |
| Dong¹ et al. | Check for updates | |
| WO2014099769A1 (en) | Pressure-sensing intravascular devices, systems, and methods | |
| JPWO2020030776A5 (en) | ||
| WO2022258561A1 (en) | Sensor assembly with set acoustic matching layer thickness for intraluminal sensing device | |
| WO2019092490A1 (en) | Rapid exchange catheter system for fractional flow reserve measurement |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication |