CN117191642A - Detection device for monitoring blood viscoelasticity change - Google Patents
Detection device for monitoring blood viscoelasticity change Download PDFInfo
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- CN117191642A CN117191642A CN202311180968.2A CN202311180968A CN117191642A CN 117191642 A CN117191642 A CN 117191642A CN 202311180968 A CN202311180968 A CN 202311180968A CN 117191642 A CN117191642 A CN 117191642A
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- 239000008280 blood Substances 0.000 title claims abstract description 65
- 210000004369 blood Anatomy 0.000 title claims abstract description 65
- 238000001514 detection method Methods 0.000 title claims abstract description 31
- 230000008859 change Effects 0.000 title claims abstract description 20
- 238000012544 monitoring process Methods 0.000 title claims abstract description 20
- 239000007788 liquid Substances 0.000 claims abstract description 93
- 230000006835 compression Effects 0.000 claims abstract description 17
- 238000007906 compression Methods 0.000 claims abstract description 17
- 238000009736 wetting Methods 0.000 claims abstract description 16
- 230000009471 action Effects 0.000 claims description 18
- 239000000758 substrate Substances 0.000 claims description 5
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 11
- 238000000034 method Methods 0.000 description 21
- 230000008569 process Effects 0.000 description 15
- 238000010586 diagram Methods 0.000 description 12
- 230000005284 excitation Effects 0.000 description 8
- 238000001125 extrusion Methods 0.000 description 5
- 230000005484 gravity Effects 0.000 description 5
- 230000000694 effects Effects 0.000 description 2
- 230000036632 reaction speed Effects 0.000 description 2
- 238000003491 array Methods 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000005489 elastic deformation Effects 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
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Abstract
The invention discloses a detection device for monitoring viscoelasticity change of blood, which relates to the field of medical equipment, wherein liquid drops to be detected are extruded from a first end of a through hole to a vibration area through a compression device, and the vibration of the liquid drops to be detected in the vibration area is controlled through a driving plate; meanwhile, the blood sample and related reagents can be added on a forward platform, and after the blood sample and the related reagents are mixed by a dielectric wetting technology, the liquid drop to be measured is transferred to the first end of the through hole by the driving plate, so that the operation of operators is facilitated.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a detection device for monitoring blood viscoelasticity change.
Background
The blood viscoelasticity change can reflect the dynamic change of blood coagulation, and further can analyze and evaluate the coagulation state of the blood sample to be tested. Currently, in order to monitor the viscoelastic change of blood, a blood sample to be measured is generally contacted with an upward-placed detecting device, and vibration of the blood sample to be measured in the detecting device can be controlled by a dielectric wetting technology: in the process of controlling vibration of a blood sample to be tested, firstly increasing the contact angle of the blood sample to be tested and the contact surface to a high-amplitude state with a larger contact angle, then reducing the contact angle of the blood sample to be tested and the contact surface, then canceling the electric excitation of dielectric wetting, so that the blood sample to be tested is rebounded to a natural state by virtue of self elasticity, and then increasing the contact angle of the blood sample to be tested and the contact surface to the high-amplitude state with a larger contact angle, namely completing one-time vibration, thereby determining the viscoelasticity change of the blood according to vibration data of the blood sample to be tested.
However, in the method, in the vibration process, the blood sample to be measured is subjected to the action force of the dielectric wetting technology and the action of gravity, so that the contact angle of the blood sample to be measured is reduced, the blood sample to be measured spreads too far, the resonance amplitude of the blood sample to be measured is affected, and the amplitude observation of the blood sample to be measured is not obvious.
Disclosure of Invention
The invention aims to provide a detection device for monitoring the viscoelasticity change of blood, which increases the contact angle of a liquid drop to be detected and a contact surface, reduces the influence of the gravity of the liquid drop on the amplitude of the liquid drop, ensures that the vibration of the observed liquid drop is more obvious, and the vibration amplitude of the liquid drop is easier to observe.
In order to solve the technical problems, the invention provides a detection device for monitoring the viscoelasticity change of blood, which comprises a driving plate and a compression device;
the driving plate is provided with a through hole, and is provided with a vibrating area which is arranged downwards, and the first end of the through hole faces upwards and is used for moving liquid drops to be tested to the first end of the through hole;
the compression device is arranged above the through hole of the driving plate and is used for extruding the liquid drop to be detected at the first end of the through hole to the vibration area;
the driving plate is used for electrically exciting the liquid drop to be tested in the vibration area when the liquid drop to be tested moves to the vibration area, so that the liquid drop to be tested vibrates at a preset frequency.
In one aspect, the compression device includes:
a fixed housing disposed on the driving plate;
the piston rod is arranged above the through hole of the driving plate through the fixed shell, the lower end of the piston rod is connected with the flexible piston cover and used for pushing the flexible piston cover to elastically deform so that liquid drops to be detected at the first end of the through hole are extruded to the vibration area;
the flexible piston cover is arranged above the through hole.
In one aspect, the compression device further comprises:
and the resetting device is arranged on the fixed shell and is used for driving the piston rod and the flexible piston cover to reset.
On the one hand, the resetting device is an elastic piece, and two ends of the elastic piece are respectively connected with the fixed shell and the piston rod.
On the one hand, when the upper end of the piston rod is provided with the outwards extending fixed block, two ends of the elastic piece are respectively connected with the fixed shell and the fixed block, and the elastic piece is sleeved on the piston rod.
In one aspect, the fixed housing is covered on the driving plate, and a gap with a preset distance is formed between the fixed housing and the driving plate, so that the liquid drop to be measured moves in the gap.
In one aspect, the stationary housing has a piston cavity disposed above the through bore, the piston rod and the flexible piston housing being movably disposed within the piston cavity.
In one aspect, the driving plate includes:
the positive driving layer is upwards arranged and is used for moving the liquid drop to be detected to the first end of the through hole;
a base layer disposed under the forward driving layer;
the inversion vibration layer is arranged below the substrate layer and is provided with a downward vibration area, and the inversion vibration layer is used for electrically exciting the liquid drop to be tested in the vibration area when the liquid drop to be tested moves to the vibration area so as to enable the liquid drop to be tested to vibrate at a preset frequency;
the through hole penetrates through the forward driving layer, the base layer and the inverted vibration layer.
In one aspect, the forward driving layer includes:
and the first electrode layer is arranged on the substrate layer and is used for moving the liquid drop to be tested to the first end of the through hole according to dielectric wetting action.
In one aspect, the inverted vibration layer includes:
the second electrode layer is arranged below the basal layer and is used for electrically exciting the liquid drop to be measured in the vibration area when the liquid drop to be measured moves to the vibration area so as to enable the liquid drop to be measured to vibrate at a preset frequency.
The invention provides a detection device for monitoring the viscoelasticity change of blood, which is characterized in that a liquid drop to be detected is extruded from a first end of a through hole to a vibration area through a compression device, and the vibration of the liquid drop to be detected in the vibration area is controlled through a driving plate; meanwhile, the blood sample and related reagents can be added on a forward platform, and after the blood sample and the related reagents are mixed by a dielectric wetting technology, the liquid drop to be measured is transferred to the first end of the through hole by the driving plate, so that the operation of operators is facilitated.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required in the prior art and the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a detecting device for monitoring viscoelastic change of blood according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a detection device provided by an embodiment of the present invention when a droplet to be detected moves to a first end of a through hole;
FIG. 3 is a schematic structural diagram of a detecting device when a compressing device is forced to move downwards according to an embodiment of the present invention;
fig. 4 is a schematic structural diagram of a detection device provided by an embodiment of the present invention when a flexible piston cover is compressed by a piston rod and elastically deformed;
fig. 5 is a schematic structural diagram of a detection device for moving a droplet to be detected to a vibration area according to an embodiment of the present invention;
fig. 6 is a schematic diagram of vibration of a droplet to be tested according to an embodiment of the present invention.
Detailed Description
The invention has the core of providing a detection device for monitoring the viscoelasticity change of blood, increasing the contact angle of a liquid drop to be detected and a contact surface, reducing the influence of the gravity of the blood drop on the amplitude of the blood drop, leading the vibration of the observed blood drop to be more obvious and the vibration amplitude of the blood drop to be more easily observed, simultaneously realizing the addition of blood samples and related reagents on a forward platform, mixing the blood samples and the related reagents through a dielectric wetting technology, and being convenient for operators to operate.
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments of the present invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a detection device for monitoring blood viscoelasticity change, where the detection device includes a driving plate 101 and a compression device 102;
the driving plate 101 is provided with a through hole, the driving plate 101 is provided with a vibrating area which is arranged downwards, and the first end of the through hole faces upwards and is used for moving liquid drops to be tested to the first end of the through hole;
the compression device 102 is arranged above the through hole of the driving plate 101 and is used for extruding the liquid drop to be tested at the first end of the through hole to the vibration area;
the driving plate 101 is used for electrically exciting the droplet to be measured in the vibration area when the droplet to be measured moves to the vibration area, so that the droplet to be measured vibrates at a preset frequency.
In a specific embodiment, the process of moving the droplet to be measured to the first end of the through hole by the driving plate 101 is the process of moving the droplet to be measured to the direction of the compressing device 102 until the droplet to be measured is opposite to the compressing device 102. Further, the blood sample is added to the sample storage area through the liquid suction tool, and the blood sample and the reagent are mixed in the sample storage area to obtain liquid drops to be detected, so that the addition of the blood sample and the mixing of the blood sample and the reagent can be realized on a forward platform, and the operation of operators is facilitated; then, the driving plate 101 drives the droplet to be measured in the sample storage area to the first end of the through hole through dielectric wetting action, namely, the droplet to be measured moves to a position opposite to the compressing device 102, at this time, the driving plate 101 releases the electric attraction force of the droplet to be measured, the compressing device 102 extrudes the droplet to be measured at the first end of the through hole to the vibration area, namely, extrudes the droplet to be measured at the first end of the through hole of the driving plate 101 to the second end of the through hole, at this time, the vibration area is electrified, so that the droplet to be measured is adsorbed in the vibration area, and vibrates in an inverted state under the action of electric excitation.
Furthermore, only one driving plate 101 can drive the liquid drop to be tested in a forward state, and the electric excitation vibration detection is performed in an inverted state; meanwhile, according to different detection projects, different channel arrays are adopted for detection at the same time.
According to the detection device for monitoring the viscoelasticity change of the blood, the liquid drop to be detected is extruded to the vibration area from the first end of the through hole through the compression device 102, and the vibration of the liquid drop to be detected in the vibration area is controlled through the driving plate 101, as the vibration area on the driving plate 101 is arranged downwards, the liquid drop to be detected is inverted in the vibration process, so that the self gravity of the liquid drop to be detected and the received dielectric wetting force act on the liquid drop to be detected, and the contact angle between the liquid drop to be detected and the contact surface is increased in the process that the blood sample to be detected is rebounded to a natural state by means of the self elasticity, the influence of the self gravity of the blood drop on the vibration amplitude of the blood drop is reduced, the vibration of the observed blood drop is more obvious, and the vibration amplitude of the blood drop is easier to observe; meanwhile, the blood sample and the related reagents can be added on a forward platform, and after the blood sample and the related reagents are mixed by a dielectric wetting technology, the to-be-measured liquid drop is transferred to the first end of the through hole by the driving plate 101, so that the operation of operators is facilitated.
Based on the above embodiments:
in some embodiments, compression device 102 includes:
a fixed housing provided on the driving plate 101;
the piston rod is arranged above the through hole of the driving plate 101 through the fixed shell, the lower end of the piston rod is connected with the flexible piston cover and is used for pushing the flexible piston cover to elastically deform so that liquid drops to be detected at the first end of the through hole are extruded to the vibration area;
and the flexible piston cover is arranged above the through hole.
In a specific embodiment, the piston rod is fixed above the through hole of the driving plate 101 through the fixed casing, and the flexible piston cover is elastically deformed by moving the piston rod, specifically, when the droplet to be detected is driven to the first end of the through hole, the piston rod moves downwards, the flexible piston cover is compressed by the piston rod to be elastically deformed, the droplet to be detected is wrapped in the flexible piston cover, then the droplet to be detected is extruded to the vibration area along with the continuous downward movement of the piston rod, namely, the droplet to be detected passes through the through hole, and is adsorbed to the vibration area in an inverted state under the electric excitation action of the vibration area.
According to the embodiment, the liquid drop to be detected at the first end of the through hole is extruded to the vibration area through the piston rod and the flexible piston cover connected with the lower end of the piston rod, and the flexible piston cover is arranged above the liquid drop to be detected and is compressed by the piston rod to elastically deform, so that the liquid drop to be detected is wrapped on the liquid drop to be detected in the flexible piston cover, the flexible piston cover can cover the liquid drop to be detected, the liquid drop to be detected can not be dispersed and split in the extrusion process, the internal air pressure is changed by the flexible piston cover in an elastic deformation mode, the extrusion force of the liquid drop to be detected is generated, the total amount of the liquid drop to be detected is reduced due to the extrusion force of the compression device 102 in the extrusion process, and the reliability of a detection result is guaranteed.
In some embodiments, the compression device 102 further comprises:
and the resetting device is arranged on the fixed shell and is used for driving the piston rod and the flexible piston cover to reset.
According to the embodiment, through the reset device arranged on the fixed shell, after the liquid drop to be detected is extruded to the vibration area, the piston rod and the flexible piston cover are driven to recover to the original positions, namely, the flexible piston cover is recovered to be not elastically deformed, the distance between the flexible piston cover and the first end of the through hole ensures that the liquid drop to be detected can move to the first end of the through hole under the control of the driving plate 101, and the detection device for monitoring the viscoelasticity change of blood is convenient to control.
In some embodiments, the resetting device is an elastic piece, and two ends of the elastic piece are respectively connected with the fixed shell and the piston rod.
The elastic part is a mechanical part which works by utilizing elasticity, is made of elastic materials, deforms under the action of external force, and returns to the original state after the external force is removed. The elastic member is mainly a disc-shaped elastic member, an annular elastic member, a plate elastic member, a spiral elastic member, a truncated cone scroll elastic member, a torsion bar elastic member and the like, wherein the common cylindrical elastic member is simple to manufacture, can be manufactured into various types according to loading conditions, has a simple structure, is most widely applied, and can be selected from any one of the elastic members in the embodiment.
According to the embodiment, the reset function of the reset device is realized through the elastic piece, meanwhile, when the piston rod is pressed down, a certain resistance is given to the piston rod, the situation that the piston rod is pressed down too quickly to influence the flexible piston cover to compress liquid drops to be detected is prevented, and the reliability of the detection result is further improved.
In some embodiments, when the upper end of the piston rod is provided with the fixing block extending outwards, two ends of the elastic piece are respectively connected with the fixing shell and the fixing block, and the elastic piece is sleeved on the piston rod.
In the specific embodiment, the upper end of the piston rod is provided with an outwardly extending fixed block, namely the cross section of the piston rod is T-shaped, the elastic piece is sleeved on the columnar part of the piston rod, one end of the elastic piece is connected with the fixed block at the upper end of the piston rod, and the other end of the elastic piece is connected with the fixed shell.
According to the embodiment, the elastic piece is sleeved on the piston rod, and due to the limiting effect of the piston rod, the elastic piece sleeved outside the piston rod is not easy to generate displacement in the horizontal direction, so that the elastic piece can stably move up and down in the resetting process, the form stability of the elastic piece is kept, and the service life of the elastic piece is prolonged.
In some embodiments, a fixed housing is disposed on the driving plate 101, and a gap is formed between the fixed housing and the driving plate 101 at a predetermined distance, so that the droplet to be measured moves in the gap.
In this embodiment, the fixed housing is covered on the driving board 101, so that the elastic device can be firmly fixed on the driving board 101, and meanwhile, a gap with a preset distance is formed between the fixed housing and the driving board 101, and the gap can ensure that the droplet to be detected smoothly moves under the dielectric wetting action of the driving board 101, so that the droplet to be detected is not interfered by the outside in the moving process, and the reliability of the detection result is further improved.
In some embodiments, the stationary housing has a piston cavity disposed above the through bore, the piston rod and the flexible piston cap being movably disposed within the piston cavity.
According to the embodiment, through the piston cavity which is arranged on the fixed shell and is opposite to the through hole, the movement of the piston rod is limited, the piston rod is fixed, the piston rod and the flexible piston cover are kept in a state opposite to the through hole, the piston rod and the flexible piston cover are prevented from being displaced in the front-back left-right direction when moving, the extrusion force for extruding the liquid drop to be detected is perpendicular to the liquid drop to be detected and the through hole, and the reliability of the detection result is guaranteed.
In some embodiments, the drive plate 101 includes:
the positive driving layer is upwards arranged and is used for moving the liquid drop to be tested to the first end of the through hole;
a base layer disposed under the forward driving layer;
the inversion vibration layer is arranged below the basal layer and is provided with a downward vibration area, and the inversion vibration layer is used for electrically exciting the liquid drop to be tested in the vibration area when the liquid drop to be tested moves to the vibration area so as to enable the liquid drop to be tested to vibrate at a preset frequency;
the through hole penetrates through the forward driving layer, the basal layer and the inverted vibration layer.
In a specific embodiment, a blood sample is added to a sample storage area through a liquid suction tool, and the blood sample and a reagent are mixed in the sample storage area to obtain liquid drops to be detected; and then the forward driving layer drives the liquid drop to be detected in the sample storage area to the first end of the through hole through dielectric wetting action, at the moment, the electric attraction of the forward driving layer to the liquid drop to be detected at the first end of the through hole is relieved, when the liquid drop to be detected is extruded by the compression device 102, so that the liquid drop to be detected moves to the vibration area through the through holes penetrating the forward driving layer, the basal layer and the inverted vibration layer, the vibration area of the inverted vibration layer is electrified, the liquid drop to be detected is adsorbed in the vibration area through electric energy action, and the electric excitation action is carried out on the liquid drop to be detected, so that the liquid drop to be detected vibrates at a preset frequency.
In the embodiment, the driving plate 101 is formed by the forward driving layer, the basal layer and the inverted vibration layer together, so that layered control of the driving plate 101 is realized, the control of the electric excitation action of the liquid drop to be detected is accurate, and the reliability of the detection result is improved.
In some embodiments, the forward driving layer includes:
and the first electrode layer is arranged on the basal layer and is used for moving the liquid drop to be tested to the first end of the through hole according to dielectric wetting action.
According to the embodiment, through the design of the forward driving layer, the miniaturization of the detection device is easy to achieve, the reaction speed is high when the use amount of the sample is small, and the detection of the blood viscoelasticity change is convenient to achieve.
In some embodiments, inverting the vibration layer includes:
the second electrode layer is arranged below the substrate layer and is used for electrically exciting the liquid drop to be tested in the vibration area when the liquid drop to be tested moves to the vibration area so as to enable the liquid drop to be tested to vibrate at a preset frequency.
According to the embodiment, through the design of the inverted vibrating layer, the miniaturization of the detection device is easy to achieve, the reaction speed is high when the using amount of the sample is small, and the detection of the viscoelasticity change of blood is convenient to achieve.
In a specific embodiment, please refer to fig. 2, 3, 4 and 5, fig. 2 is a schematic structural diagram of a detection device provided in the embodiment of the present invention when a droplet to be detected moves to a first end of a through hole; FIG. 3 is a schematic structural diagram of a detecting device when a compressing device is forced to move downwards according to an embodiment of the present invention; fig. 4 is a schematic structural diagram of a detection device provided by an embodiment of the present invention when a flexible piston cover is compressed by a piston rod and elastically deformed; fig. 5 is a schematic structural diagram of a detection device for moving a droplet to be detected to a vibration area according to an embodiment of the present invention.
The upper end of the flexible piston cover 204 is sleeved on the lower end of the piston rod 201 with a T-shaped cross section, the piston rod 201 is connected with the flexible piston cover 204, the fixed shell 203 is provided with a piston cavity, the piston cavity is arranged above the through hole, and the piston rod 201 and the flexible piston cover 204 are movably arranged in the piston cavity. When the liquid drop to be measured moves to the first end of the through hole, a vertical downward pressure is applied to the fixed block on the piston rod 201, the piston rod 201 moves downwards against the resistance of the elastic piece 202, the flexible piston cover 204 is pushed to be tightly attached to the driving plate 101, the liquid drop to be measured at the first end of the through hole is wrapped in the flexible piston cover 204 by the flexible piston cover 204, at the moment, the vertical downward pressure is continuously applied to the piston rod 201, the volume of the flexible piston cover 204 is driven to shrink, the air pressure of a cavity where the liquid drop to be measured is located is increased, and the liquid drop to be measured is extruded to a vibration area which passes through the through hole and moves to the inversion direction of the driving plate 101; when there is no downward force on the fixed block on the piston rod 201, the elastic member 202 drives the piston rod 201 and the flexible piston cover 204 to reset.
Fig. 6 is a schematic diagram of vibration of a droplet to be tested according to an embodiment of the present invention, referring to fig. 6 in the process of vibration of a droplet to be tested:
the drop to be measured vibrates up and down under the action of electric excitation, so that the drop to be measured which just enters the vibration area of the driving plate 101 is observed to be in a high-amplitude state 1 of the drop to be measured, then the coplanar electrode is electrified, the drop to be measured generates a dielectric wetting effect, the contact angle between the drop to be measured and the surface of the coplanar electrode is reduced, the drop to be measured can be flattened integrally, and the vibration of the drop to be measured passes through a medium-amplitude state 2 and reaches a lowest-amplitude state 3 of the drop to be measured; the coplanar electrode is powered off, the dielectric wetting effect disappears, the liquid drop to be tested rebounds by the elastic force of the coplanar electrode, the liquid drop to be tested returns to the high-amplitude state 5 of the liquid drop to be tested after passing through the medium-amplitude state 4 of the vibration of the liquid drop to be tested, and the process completes one-time electric excitation of the vibration of the blood drop.
In the present specification, each embodiment is described in a progressive manner, and each embodiment is mainly described in a different point from other embodiments, and identical and similar parts between the embodiments are all enough to refer to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant points refer to the description of the method section.
It should also be noted that in this specification, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (10)
1. A detection device for monitoring the viscoelasticity change of blood, which is characterized by comprising a driving plate and a compression device;
the driving plate is provided with a through hole, and is provided with a vibrating area which is arranged downwards, and the first end of the through hole faces upwards and is used for moving liquid drops to be tested to the first end of the through hole;
the compression device is arranged above the through hole of the driving plate and is used for extruding the liquid drop to be detected at the first end of the through hole to the vibration area;
the driving plate is used for electrically exciting the liquid drop to be tested in the vibration area when the liquid drop to be tested moves to the vibration area, so that the liquid drop to be tested vibrates at a preset frequency.
2. The device for monitoring changes in viscoelasticity of blood according to claim 1, wherein said compression means comprises:
a fixed housing disposed on the driving plate;
the piston rod is arranged above the through hole of the driving plate through the fixed shell, the lower end of the piston rod is connected with the flexible piston cover and used for pushing the flexible piston cover to elastically deform so that liquid drops to be detected at the first end of the through hole are extruded to the vibration area;
the flexible piston cover is arranged above the through hole.
3. The device for monitoring changes in viscoelasticity of blood according to claim 2, wherein said compression device further comprises:
and the resetting device is arranged on the fixed shell and is used for driving the piston rod and the flexible piston cover to reset.
4. A device for monitoring a viscoelastic change of blood according to claim 3, wherein the resetting device is an elastic member, and both ends of the elastic member are respectively connected to the fixed housing and the piston rod.
5. The device for detecting changes in viscoelasticity of blood according to claim 4, wherein when the upper end of the piston rod is provided with a fixing block extending outward, both ends of the elastic member are respectively connected with the fixing housing and the fixing block, and the elastic member is sleeved on the piston rod.
6. The device for detecting changes in viscoelasticity of blood according to claim 2, wherein the stationary housing is covered on the driving plate, and a gap is provided between the stationary housing and the driving plate at a predetermined distance so that the droplet to be detected moves in the gap.
7. The device for monitoring changes in viscoelasticity of blood according to claim 6, wherein the stationary housing has a piston chamber disposed above the through bore, the piston rod and the flexible piston housing being movably disposed within the piston chamber.
8. A test device for monitoring changes in blood viscoelasticity according to any one of claims 1 to 7, wherein the drive plate comprises:
the positive driving layer is upwards arranged and is used for moving the liquid drop to be detected to the first end of the through hole;
a base layer disposed under the forward driving layer;
the inversion vibration layer is arranged below the substrate layer and is provided with a downward vibration area, and the inversion vibration layer is used for electrically exciting the liquid drop to be tested in the vibration area when the liquid drop to be tested moves to the vibration area so as to enable the liquid drop to be tested to vibrate at a preset frequency;
the through hole penetrates through the forward driving layer, the base layer and the inverted vibration layer.
9. The device for monitoring changes in blood viscoelasticity according to claim 8, wherein the forward driving layer comprises:
and the first electrode layer is arranged on the substrate layer and is used for moving the liquid drop to be tested to the first end of the through hole according to dielectric wetting action.
10. The device for monitoring changes in viscoelasticity of blood according to claim 8, wherein said inverted vibration layer comprises:
the second electrode layer is arranged below the basal layer and is used for electrically exciting the liquid drop to be measured in the vibration area when the liquid drop to be measured moves to the vibration area so as to enable the liquid drop to be measured to vibrate at a preset frequency.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311180968.2A CN117191642A (en) | 2023-09-13 | 2023-09-13 | Detection device for monitoring blood viscoelasticity change |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202311180968.2A CN117191642A (en) | 2023-09-13 | 2023-09-13 | Detection device for monitoring blood viscoelasticity change |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN117191642A true CN117191642A (en) | 2023-12-08 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202311180968.2A Pending CN117191642A (en) | 2023-09-13 | 2023-09-13 | Detection device for monitoring blood viscoelasticity change |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN117191642A (en) |
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2023
- 2023-09-13 CN CN202311180968.2A patent/CN117191642A/en active Pending
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