CN117085066A - Traditional Chinese medicine composition for treating peripheral facial paralysis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating peripheral facial paralysis and preparation method thereof Download PDFInfo
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- CN117085066A CN117085066A CN202311237386.3A CN202311237386A CN117085066A CN 117085066 A CN117085066 A CN 117085066A CN 202311237386 A CN202311237386 A CN 202311237386A CN 117085066 A CN117085066 A CN 117085066A
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Abstract
The invention discloses a traditional Chinese medicine composition for treating peripheral facial paralysis and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 15-25 parts of honeysuckle, 7-15 parts of weeping forsythiae capsule, 8-15 parts of wild chrysanthemum flower, 7-15 parts of radix isatidis, 8-18 parts of cicada slough, 10-18 parts of scorpion, 8-16 parts of stiff silkworm, 10-18 parts of centipede, 8-15 parts of large-leaf gentian root, 4-12 parts of radix bupleuri, 4-12 parts of notopterygium root, 4-12 parts of radix angelicae pubescentis, 15-25 parts of kudzuvine root, 5-10 parts of divaricate saposhnikovia root, 5-10 parts of dahurian angelica root, 10-20 parts of stir-fried white paeony root, 4-12 parts of cassia twig, 5-15 parts of Chinese angelica, 4-12 parts of szechuan lovage rhizome, 2-10 parts of asarum, 8-15 parts of white atractylodes rhizome, 15-25 parts of astragalus root, 10-20 parts of Indian buead and 3-10 parts of liquorice. The traditional Chinese medicine composition provided by the invention has the effects of clearing heat and detoxicating, detumescence and resolving masses, dispelling wind and resolving phlegm, and dredging collaterals and relieving spasm, and has obvious curative effect on treating peripheral facial paralysis.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating peripheral facial paralysis and a preparation method thereof.
Background
Facial paralysis, also known as facial neuritis, commonly called as "facial paralysis", is a common disease characterized by dyskinesia of facial expression muscle groups, and is a clinically frequently occurring disease, a serious disease, improper treatment or delay, which can lead to paralysis sequelae of different degrees. The disease can occur at any age, the male is more than the female, the disease is rapid, the facial paralysis reaches a peak within a few hours to 1-2 days, the physical and mental health and the quality of life of patients are seriously affected, and the severity is only inferior to that of the schizophrenia.
Facial paralysis is generally considered to be caused by deficiency of body healthy qi, empty venation, loose defensive qi, deficiency of pathogenic wind-cold, obstruction of meridians, unsmooth qi and blood circulation, malnutrition of the meridians and tendons of the face due to pathogenic wind in the venation, and muscle relaxation and non-recovery; or excessive yang of the body, or invasion of pathogenic wind-heat; or prolonged illness; or impairment of qi and blood due to consumption. Modern medicine considers that facial paralysis is spasm caused by local nutritional nerve blood vessel subjected to wind-cold, and causes ischemia and edema of nerve tissue; or the facial nerve is swollen and pressed due to inflammation, and acute facial nerve dysfunction is caused. At present, the incidence rate of facial paralysis in China accounts for the sixth of the whole nervous system diseases, and about 300 thousands of new cases exist each year.
Although a plurality of treatment means (plaster, acupuncture, oral traditional Chinese medicine conditioning, oral administration, western medicine injection and the like) for peripheral facial paralysis exist at the present stage, medicines aiming at the acute stage of peripheral facial paralysis are relatively few, and the curative effect of the medicines is not satisfactory, so that the development of new medicines is imperative.
The traditional Chinese medicine composition is a common composition for treating facial paralysis (peripheral facial paralysis), and is modified on the basis of the proved recipe of facial paralysis traction particles, so that side effects are reduced, the curative effect is more definite, and the safety and effectiveness of facial paralysis administration are further laid.
Disclosure of Invention
The invention aims to overcome the defects of lack of medicines, unsatisfactory effects and the like in the prior art for treating facial paralysis (peripheral facial paralysis), and provides a traditional Chinese medicine composition for treating the peripheral facial paralysis, which takes honeysuckle and weeping forsythiae capsule as monarch drugs, and wild chrysanthemum flower, isatis root, scorpion, cicada slough, stiff silkworm and centipede as ministerial drugs, and the scorpion, the cicada slough, the stiff silkworm and the centipede are used together to extinguish wind and stop spasm, unblock collaterals and relieve pain; the gentiana macrophylla is pungent, bitter and flat in nature, has the effects of dispelling wind and removing dampness, clearing heat and removing arthralgia, dredging collaterals and relieving pain, is combined with the notopterygium root, the radix angelicae pubescentis, the radix sileris and the radix angelicae dahuricae Xin Wenzhi, can dispel wind and release exterior, and can dispel pathogenic factors by virtue of the channeling force of asarum; radix bupleuri and radix puerariae are used for dispelling wind and dissipating heat; chinese angelica and szechuan lovage rhizome have the effects of promoting blood circulation, removing blood stasis, promoting qi circulation and relieving pain; ramulus Cinnamomi and radix Paeoniae alba are pungent and dispersed to remove meridian obstruction and harmonize nutrient and defensive qi; the bighead atractylodes rhizome, the astragalus root, the poria cocos and the liquorice have the effects of strengthening the spleen, tonifying qi, reducing phlegm and dehumidifying, so that the traditional Chinese medicine composition has the effects of clearing heat and detoxicating, relieving swelling and resolving masses, dispelling wind and resolving phlegm, and dredging collaterals and relieving spasm.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
a traditional Chinese medicine composition for treating peripheral facial paralysis comprises the following raw materials in parts by weight: 15-25 parts of honeysuckle, 7-15 parts of weeping forsythiae capsule, 8-15 parts of wild chrysanthemum flower, 7-15 parts of radix isatidis, 8-18 parts of cicada slough, 10-18 parts of scorpion, 8-16 parts of stiff silkworm, 10-18 parts of centipede, 8-15 parts of large-leaf gentian root, 4-12 parts of radix bupleuri, 4-12 parts of notopterygium root, 4-12 parts of radix angelicae pubescentis, 15-25 parts of kudzuvine root, 5-10 parts of divaricate saposhnikovia root, 5-10 parts of dahurian angelica root, 10-20 parts of stir-fried white paeony root, 4-12 parts of cassia twig, 5-15 parts of Chinese angelica, 4-12 parts of szechuan lovage rhizome, 2-10 parts of asarum, 8-15 parts of white atractylodes rhizome, 15-25 parts of astragalus root, 10-20 parts of Indian buead and 3-10 parts of liquorice.
Further, the traditional Chinese medicine composition is any pharmaceutically acceptable dosage form.
Further, the pharmaceutically acceptable dosage forms are granules, oral solutions, tablets, capsules or pills.
Further, the Chinese medicinal composition is used for treating facial paralysis (peripheral facial paralysis).
Further, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
17-25 parts of honeysuckle, 10-15 parts of weeping forsythiae capsule, 10-15 parts of wild chrysanthemum flower, 9-15 parts of radix isatidis, 10-16 parts of cicada slough, 10-16 parts of scorpion, 10-15 parts of stiff silkworm, 10-16 parts of centipede, 10-14 parts of large-leaf gentian root, 7-10 parts of radix bupleuri, 7-10 parts of notopterygium root, 7-10 parts of radix angelicae pubescentis, 17-25 parts of kudzuvine root, 7-10 parts of divaricate saposhnikovia root, 7-10 parts of dahurian angelica root, 10-15 parts of stir-fried white paeony root, 5-10 parts of cassia twig, 5-10 parts of Chinese angelica, 5-10 parts of szechuan lovage rhizome, 3-5 parts of manchurian wildginger, 10-14 parts of largehead atractylodes rhizome, 16-20 parts of astragalus root, 11-15 parts of Indian buead and 5-9 parts of liquorice.
Preferably, in one or more embodiments of the present invention, the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus, 13 parts of poria cocos and 5 parts of liquorice;
or 17 parts of honeysuckle, 10 parts of weeping forsythia, 10 parts of wild chrysanthemum flower, 9 parts of radix isatidis, 10 parts of cicada slough, 10 parts of scorpion, 10 parts of stiff silkworm, 10 parts of centipede, 10 parts of large-leaf gentian root, 8 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 17 parts of kudzuvine root, 8 parts of radix sileris, 8 parts of angelica dahurica, 10 parts of stir-fried white paeony root, 5 parts of cassia twig, 5 parts of angelica sinensis, 5 parts of szechuan lovage rhizome, 3 parts of asarum, 10 parts of bighead atractylodes rhizome, 16 parts of astragalus root, 11 parts of poria cocos and 5 parts of liquorice;
or 20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 10 parts of gentiana macrophylla, 9 parts of radix bupleuri, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 12 parts of stir-fried white paeony root, 6 parts of cassia twig, 6 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 12 parts of Indian buead and 5 parts of liquorice;
or 22 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 11 parts of radix isatidis, 13 parts of cicada slough, 13 parts of scorpion, 13 parts of stiff silkworm, 13 parts of centipede, 10 parts of large-leaf gentian root, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 7 parts of radix sileris, 7 parts of angelica dahurica, 10 parts of stir-fried white paeony root, 7 parts of cassia twig, 7 parts of angelica, 7 parts of szechuan lovage rhizome, 3 parts of asarum, 10 parts of bighead atractylodes rhizome, 16 parts of astragalus root, 11 parts of poria cocos and 5 parts of liquorice;
or 25 parts of honeysuckle, 15 parts of weeping forsythia, 15 parts of wild chrysanthemum flower, 15 parts of radix isatidis, 16 parts of cicada slough, 16 parts of scorpion, 15 parts of stiff silkworm, 16 parts of centipede, 14 parts of gentiana macrophylla, 10 parts of radix bupleuri, 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 25 parts of kudzuvine root, 10 parts of radix sileris, 10 parts of angelica dahurica, 15 parts of stir-fried white peony root, 10 parts of cassia twig, 10 parts of angelica, 10 parts of szechuan lovage rhizome, 5 parts of asarum, 14 parts of bighead atractylodes rhizome, 20 parts of astragalus, 15 parts of poria cocos and 9 parts of liquorice.
The invention further provides a preparation method of the traditional Chinese medicine composition according to any one of the previous claims, which comprises the following steps:
a) Soaking flos Lonicerae, fructus forsythiae, notopterygii rhizoma, radix Angelicae Pubescentis, ramulus Cinnamomi, radix Saposhnikoviae, radix Gentianae Marcrophyllae, bupleuri radix, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, herba asari, and Atractylodis rhizoma in water for 1-3 hr, extracting volatile oil by steam distillation, and collecting volatile oil; collecting distilled water solution in another container; the temperature of the warm dip is preferably 50 ℃.
B) Mixing the residue after extracting volatile oil with the rest materials, decocting with water for 1-3 times, each for 1-3 hr, mixing filtrates, filtering, and mixing the filtrate with the above water solution to obtain extractive solution;
c) Concentrating the extracting solution to obtain a concentrated solution; the relative density of the concentrated solution at 60 ℃ is 1.10-1.20;
d) Mixing the concentrated solution in the step C with ethanol until the alcohol content is 60% -70%, and performing alcohol precipitation to obtain an alcohol precipitation supernatant;
e) Concentrating the supernatant at 40-60deg.C to obtain fluid extract with relative density of 1.10-1.30;
f) E, placing the clear paste obtained in the step E at the temperature of-80 ℃ to-60 ℃ for freeze drying to obtain dry paste;
g) Clathrating the volatile oil collected in the step A by adopting a saturated aqueous solution method to obtain a volatile oil clathrate;
h) And D, crushing the dry paste obtained in the step F, and then uniformly mixing the dry paste with the volatile oil inclusion compound obtained in the step G and a proper amount of auxiliary materials to obtain a target product, namely the traditional Chinese medicine composition.
Further, the time for extracting the volatile oil in the step A) is 4-6 hours, preferably 5 hours.
Further, in the step B), the mass ratio of water to the total amount of each raw material medicine is 6-15.
Compared with the prior art, the invention has the following beneficial effects:
the traditional Chinese medicine composition provided by the invention is prepared from the selected raw materials according with the compatibility principle of monarch, minister, assistant and guide, and in the formula, honeysuckle and weeping forsythiae are taken as monarch drugs, so that the traditional Chinese medicine composition has the effects of clearing heat, detoxicating and dispelling wind and heat; honeysuckle flower, sweet in flavor, cold in nature, has the efficacy of dispelling wind and heat, is mainly used for treating common cold fever, epidemic febrile disease fever and other symptoms. Fructus forsythiae, bitter in flavor and slightly cold in nature, has the effects of relieving swelling, resolving hard mass, clearing heat and detoxicating, and is mainly used for treating diseases such as warm-heat nutrient, high-heat polydipsia, wind-heat cold and the like. The two components cooperate to have the effects of clearing away heat and toxic materials, detumescence, resolving hard mass and dispelling wind and heat.
The wild chrysanthemum flower, the isatis root, the cicada slough, the stiff silkworm, the scorpion and the centipede are used as ministerial drugs, the wild chrysanthemum flower is bitter and pungent in taste and slightly cold in nature, has the effects of clearing heat and detoxicating, purging fire and calming liver, and is mainly used for treating furuncle and carbuncle swelling, conjunctival congestion and swelling and other symptoms; radix Isatidis has bitter taste and cold nature, has effects of clearing heat and detoxicating, cooling blood and relieving sore throat, and can be used for treating fever and pharyngalgia, carbuncle and swelling etc., both of which can enhance the effects of flos Lonicerae, fructus forsythiae, removing toxic substance and eliminating pathogenic factor. The stiff silkworm has salty and pungent taste and mild nature, and has the effects of dispelling wind, relieving pain, reducing phlegm and resolving masses; the periostracum cicadae is sweet and salty in taste and cool in nature, has the effects of dispelling wind and heat, calming endogenous wind and relieving spasm, and has the effects of clearing heat and dispelling wind, relieving exterior syndrome and eliminating stagnation; scorpio Xin Ping has effects in calming endogenous wind, relieving spasm, dredging collaterals, and relieving pain; wu Gong is pungent and warm in nature and toxic, good at moving, stopping wind and relieving convulsion, and is the key herb for dispelling wind and relieving spasm, so it is combined with quan Xie to have more remarkable effect of relieving spasm.
Gentiana macrophylla, bupleurum, notopterygium root, radix angelicae pubescentis, kudzuvine root, radix sileris, angelica dahurica, fried white peony root, cassia twig, szechuan lovage rhizome and asarum are used as adjuvant drugs. The gentiana macrophylla is pungent, bitter and flat in nature, has the effects of dispelling wind and removing dampness, clearing heat and removing arthralgia, dredging collaterals and relieving pain, is combined with the notopterygium root, the radix angelicae pubescentis, the radix sileris and the radix angelicae dahuricae Xin Wenzhi, can dispel wind and release exterior, and can dispel pathogenic factors by virtue of the channeling force of asarum; radix bupleuri lifts yang qi, soothes liver, relieves depression, dissipates heat, relieves muscular exterior syndrome, and is combined with wind dispelling and heat dissipating effects; chuan Xiong is spicy and fragrant, moves upward toward the head and eyes, reaches the blood sea, moves qi and activates blood, dispels wind and relieves pain, is a blood medicine in qi, and is combined with Dang Gui to strengthen the actions of activating blood and removing stasis, and moving qi and relieving pain; ramulus Cinnamomi can induce sweat to relieve muscle, wen Tongjin pulse, radix Paeoniae alba can nourish blood and regulate nutrient, and liver and relieve urgency, and both are combined with pungent and dispersed collaterals to regulate nutrient and defensive qi. The bighead atractylodes rhizome has the effects of strengthening spleen and replenishing qi, the astragalus root has the effects of invigorating qi and raising yang, the poria cocos has the effects of promoting diuresis and excreting dampness, the liquorice root has the effects of invigorating spleen and replenishing qi, the four are combined with each other as guiding drugs, so they can strengthen the spleen, replenish qi, resolve phlegm and dehumidify, and the licorice root can play a role in harmonizing the drugs. The medicines in the whole formula have special effects on the aspects, supplement each other, cooperate to be used, and have multiplied efficacy.
The traditional Chinese medicine composition provided by the invention has the effects of clearing heat and detoxicating, detumescence and resolving masses, dispelling wind and resolving phlegm, dredging collaterals and relieving spasm. On the basis, the dosage of the medicinal materials is flexibly adjusted according to the addition and subtraction of the medicinal materials of the clinical symptoms of the patients, so that the disease progression can be more effectively controlled. Thus, the Chinese medicinal composition improves symptoms such as facial distortion of patients and has obvious curative effect on peripheral facial paralysis.
Drawings
FIG. 1 is a graph showing lip blood perfusion of rats in blank, model, positive and example 3, 7 days and 14 days of gavage with the Chinese medicinal composition;
FIG. 2 is a diagram showing perfusion of lip blood of high, medium and low dose groups of rats in example 3;
FIG. 3 is a graph showing perfusion of lips of rats with the Chinese medicinal composition of comparative examples 13-18 for 7 days and 14 days.
Detailed Description
In order that the invention may be readily understood, a more particular description of the invention will be rendered by reference to specific embodiments that are illustrated below. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The invention provides a traditional Chinese medicine composition for treating peripheral facial paralysis, which comprises the following raw materials in parts by weight: 15-25 parts of honeysuckle, 7-15 parts of weeping forsythiae capsule, 8-15 parts of wild chrysanthemum flower, 7-15 parts of radix isatidis, 8-18 parts of cicada slough, 10-18 parts of scorpion, 8-16 parts of stiff silkworm, 10-18 parts of centipede, 8-15 parts of large-leaf gentian root, 4-12 parts of radix bupleuri, 4-12 parts of notopterygium root, 4-12 parts of radix angelicae pubescentis, 15-25 parts of kudzuvine root, 5-10 parts of divaricate saposhnikovia root, 5-10 parts of dahurian angelica root, 10-20 parts of stir-fried white paeony root, 4-12 parts of cassia twig, 5-15 parts of Chinese angelica, 4-12 parts of szechuan lovage rhizome, 2-10 parts of asarum, 8-15 parts of white atractylodes rhizome, 15-25 parts of astragalus root, 10-20 parts of Indian buead and 3-10 parts of liquorice.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
the raw materials are sequentially subjected to volatile oil extraction, water extraction, alcohol precipitation and one-step granulation, so that the effective components are extracted from the pharmaceutical composition to the maximum extent, and the pharmaceutical composition still has the same effect after being prepared into granules, oral solutions, tablets, capsules or pills. The preparation of the traditional Chinese medicine composition specifically comprises the following steps:
a) Soaking flos Lonicerae, fructus forsythiae, notopterygii rhizoma, radix Angelicae Pubescentis, ramulus Cinnamomi, radix Saposhnikoviae, radix Gentianae Marcrophyllae, bupleuri radix, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, herba asari, and Atractylodis rhizoma in water for 1-3 hr, extracting volatile oil by steam distillation for 4-6 hr, and collecting volatile oil; collecting distilled water solution in another container;
b) Mixing the residue after extracting volatile oil with the rest materials, decocting with water for 1-3 times, each for 1-3 hr, mixing filtrates, filtering, and mixing the filtrate with the above water solution to obtain extractive solution; preferably, the mass ratio of water to the total amount of the raw materials is 6-15;
c) Concentrating the extracting solution to obtain a concentrated solution; the relative density of the concentrated solution at 60 ℃ is 1.10-1.20;
d) Mixing the concentrated solution in the step C) with ethanol until the alcohol content is 60% -70%, and performing alcohol precipitation to obtain an alcohol precipitation supernatant;
e) Recovering ethanol from the supernatant, and concentrating at 40-60deg.C to obtain fluid extract with relative density of 1.10-1.30;
f) Freeze-drying the clear paste obtained in the step E) at the temperature of-80 ℃ to-60 ℃ to obtain dry paste;
g) Clathrating the collected volatile oil by saturated aqueous solution method to obtain volatile oil clathrate;
h) Pulverizing the dry paste obtained in the step F), and then uniformly mixing the dry paste with the volatile oil inclusion compound obtained in the step G) and a proper amount of auxiliary materials to obtain the traditional Chinese medicine composition.
The volatile oil inclusion compound can be prepared by adopting an inclusion mode conventional in the art without special limitation, and in the embodiment of the invention, the specific steps are as follows: embedding the volatile oil with beta-cyclodextrin to form inclusion compound, and drying for later use; the embedding method of the volatile oil comprises the following steps: volatile oil in weight ratio: beta-cyclodextrin: water = 1:10:18,2mm grinding gap, grinding for 15 min to form clathrate, drying, and pulverizing into coarse powder for use;
the traditional Chinese medicine composition can be prepared into corresponding dosage forms according to conventional technical means of the person skilled in the art after being dried and crushed, and specifically:
when the traditional Chinese medicine composition is granule, the dried solid is crushed, sieved and evenly mixed with auxiliary materials for granulation.
When the traditional Chinese medicine composition is a tablet, the dried solid is crushed, sieved, mixed with auxiliary materials, granulated and tableted.
When the traditional Chinese medicine composition is in the form of a capsule, the dried solid is crushed, sieved, and then mixed with auxiliary materials, granulated and filled into the capsule.
When the traditional Chinese medicine composition is decoction, the traditional Chinese medicine raw materials are subjected to water extraction and concentration to prepare the decoction.
The technical scheme of the invention is more fully described below with reference to specific embodiments.
EXAMPLE 1 preparation of a Chinese medicinal composition
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method comprises the following specific steps:
1) Soaking flos Lonicerae, fructus forsythiae, notopterygii rhizoma, radix Angelicae Pubescentis, ramulus Cinnamomi, radix Saposhnikoviae, radix Gentianae Marcrophyllae, bupleuri radix, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, herba asari and Atractylodis rhizoma in water at 50deg.C for 3 hr, extracting volatile oil by steam distillation, and collecting volatile oil; collecting distilled water solution in another container;
2) Mixing the residue after extracting volatile oil with the rest materials, decocting with water for 3 times, the first time for 3 hr, the second time for 2 hr, and the third time for 1 hr, mixing filtrates, filtering, and mixing the filtrate with the above water solution to obtain extractive solution;
3) Concentrating the extract to a relative density of 1.20 at 60 ℃ to obtain a concentrated solution;
4) Mixing the concentrated solution in the step 3) with ethanol until the ethanol content is 70%, and performing alcohol precipitation to obtain an alcohol precipitation supernatant;
5) Recovering ethanol from the supernatant, and concentrating at 60deg.C to obtain fluid extract with relative density of 1.30;
6) Freeze-drying the concentrated solution obtained in the step 5) at the temperature of minus 60 ℃ to obtain dry paste;
7) Clathrating the collected volatile oil by saturated aqueous solution method to obtain volatile oil clathrate;
8) And (3) crushing the dry paste obtained in the step (6), and uniformly stirring and mixing 700g of the volatile oil inclusion compound obtained in the step (7) and auxiliary material starch to obtain the traditional Chinese medicine composition.
Comparative example 1 Chinese medicinal compositionPreparation of the article(compared with example 1, 14 parts of Scorpio is missing)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum, 12 parts of radix isatidis, 14 parts of cicada slough, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus mongholicus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 2 preparation of Chinese medicinal composition(absence of 14 parts of Scolopendra compared with example 1)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 7 parts of divaricate saposhnikovia root, 7 parts of dahurian angelica root, 10 parts of stir-fried white paeony root, 7 parts of cassia twig, 7 parts of angelica, 7 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 12 parts of largehead atractylodes rhizome, 18 parts of astragalus root, 13 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 3 preparation of Chinese medicinal composition(As compared with example 1, there is no gentiana macrophylla 12 parts)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 4 preparation of Chinese medicinal composition(in comparison with example 1, 7 parts of bupleurum root is absent)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 7 parts of divaricate saposhnikovia root, 7 parts of dahurian angelica root, 10 parts of stir-fried white paeony root, 7 parts of cassia twig, 7 parts of angelica, 7 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 12 parts of largehead atractylodes rhizome, 18 parts of astragalus root, 13 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 5 preparation of Chinese medicinal composition(compared with example 1, 7 parts of radix Angelicae Pubescentis are missing)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 20 parts of kudzuvine root, 7 parts of radix sileris, 7 parts of dahurian angelica root, 10 parts of stir-fried white paeony root, 7 parts of cassia twig, 7 parts of angelica, 7 parts of szechuan lovage rhizome, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus root, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 6 preparation of Chinese medicinal composition(compared with example 1, 7 parts of Angelica dahurica are missing)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 10 parts of stir-fried white peony root, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 7 preparation of Chinese medicinal composition(compared with example 1, 7 parts of Angelica sinensis are absent)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus membranaceus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 8 preparation of Chinese medicinal composition(compared with example 1, 7 parts of Ligusticum wallichii is missing)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus membranaceus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 9 preparation of Chinese medicinal composition(As compared with example 1, 3 parts of asarum were absent)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus membranaceus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 10 preparation of Chinese medicinal composition(compared with example 1, 12 parts of Atractylodis rhizoma is missing)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 18 parts of astragalus membranaceus, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 11 preparation of Chinese medicinal composition(in comparison with example 1, there is a lack of 18 parts of Astragalus membranaceus)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 13 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 12 preparation of Chinese medicinal composition(compared to example 1, poria cocos 13 is absent)
The traditional Chinese medicine composition comprises the following raw materials: 18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus and 5 parts of liquorice;
the preparation method is the same as in example 1.
EXAMPLE 2 preparation of a Chinese medicinal composition
The traditional Chinese medicine composition comprises the following raw materials: 17 parts of honeysuckle, 10 parts of weeping forsythia, 10 parts of wild chrysanthemum flower, 9 parts of radix isatidis, 10 parts of cicada slough, 10 parts of scorpion, 10 parts of stiff silkworm, 10 parts of centipede, 10 parts of large-leaf gentian root, 8 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 17 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 8 parts of dahurian angelica root, 10 parts of stir-fried white paeony root, 5 parts of cassia twig, 5 parts of Chinese angelica, 5 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 11 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
EXAMPLE 3 preparation of a Chinese medicinal composition
The traditional Chinese medicine composition comprises the following raw materials: 20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 10 parts of large-leaf gentian root, 9 parts of bupleurum, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 12 parts of stir-fried white peony root, 6 parts of cassia twig, 6 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 12 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
EXAMPLE 4 preparation of a Chinese medicinal composition
The traditional Chinese medicine composition comprises the following raw materials: 22 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 11 parts of radix isatidis, 13 parts of cicada slough, 13 parts of scorpion, 13 parts of stiff silkworm, 13 parts of centipede, 10 parts of large-leaf gentian root, 7 parts of bupleurum root, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 7 parts of divaricate saposhnikovia root, 7 parts of dahurian angelica root, 10 parts of stir-fried white peony root, 7 parts of cassia twig, 7 parts of Chinese angelica, 7 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 11 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
EXAMPLE 5 preparation of a Chinese medicinal composition
The traditional Chinese medicine composition comprises the following raw materials: 25 parts of honeysuckle, 15 parts of weeping forsythia, 15 parts of wild chrysanthemum flower, 15 parts of radix isatidis, 16 parts of cicada slough, 16 parts of scorpion, 15 parts of stiff silkworm, 16 parts of centipede, 14 parts of large-leaf gentian root, 10 parts of bupleurum root, 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 25 parts of kudzuvine root, 10 parts of divaricate saposhnikovia root, 10 parts of dahurian angelica root, 15 parts of stir-fried white peony root, 10 parts of cassia twig, 10 parts of Chinese angelica, 10 parts of szechuan lovage rhizome, 5 parts of manchurian wildginger, 14 parts of largehead atractylodes rhizome, 20 parts of astragalus root, 15 parts of Indian buead and 9 parts of liquorice;
the preparation method is the same as in example 1.
Preparation of related prescription-dismantling traditional Chinese medicine composition
Comparative example 13
Compared with example 3, comparative example 13 lacks Scorpio and Scolopendra, and the Chinese medicinal composition comprises the following components:
20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of stiff silkworm, 10 parts of gentiana macrophylla, 9 parts of radix bupleuri, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 12 parts of stir-fried white peony root, 6 parts of cassia twig, 6 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 12 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 14
Compared with example 3, comparative example 14 lacks gentiana macrophylla and asarum herb, and the traditional Chinese medicine composition comprises the following components:
20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 9 parts of radix bupleuri, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 8 parts of radix sileris, 9 parts of radix angelicae, 12 parts of fried white peony root, 6 parts of cassia twig, 6 parts of angelica sinensis, 6 parts of ligusticum wallichii, 10 parts of bighead atractylodes rhizome, 16 parts of radix astragali, 12 parts of poria cocos and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 15
Compared with example 3, the bupleurum lack and the kudzuvine root in comparative example 15 are prepared from the following traditional Chinese medicine compositions:
20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 10 parts of large-leaf gentian root, 9 parts of notopterygium root, 9 parts of pubescent angelica root, 8 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 12 parts of stir-fried white peony root, 6 parts of cassia twig, 6 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 12 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 16
Compared with example 3, comparative example 16 lacks radix Angelicae sinensis and rhizoma Ligustici Chuanxiong, and the Chinese medicinal composition comprises the following components:
20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 10 parts of large-leaf gentian root, 9 parts of bupleurum, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 12 parts of stir-fried white peony root, 6 parts of cassia twig, 3 parts of asarum, 10 parts of bighead atractylodes rhizome, 16 parts of astragalus root, 12 parts of poria cocos and 5 parts of liquorice; the preparation method is the same as in example 1.
Comparative example 17
Compared with example 3, comparative example 17 lacks radix angelicae pubescentis and radix angelicae dahuricae, and the traditional Chinese medicine composition comprises the following components:
20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 10 parts of large-leaf gentian root, 9 parts of bupleurum, 9 parts of notopterygium root, 20 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 12 parts of stir-fried white paeony root, 6 parts of cassia twig, 6 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 12 parts of Indian buead and 5 parts of liquorice;
the preparation method is the same as in example 1.
Comparative example 18
Compared with example 3, comparative example 18 lacks bighead atractylodes rhizome, astragalus and poria cocos, and the traditional Chinese medicine composition comprises the following components:
20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 10 parts of large-leaf gentian root, 9 parts of bupleurum, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 12 parts of stir-fried white peony root, 6 parts of cassia twig, 6 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger and 5 parts of liquorice;
the preparation method is the same as in example 1.
Test case
1. Pharmacological tests are carried out to investigate the influence of the traditional Chinese medicine composition on the facial paralysis model of the male rat.
1. Sample preparation
(1) Taking the Chinese medicinal compositions of example 1 and example 3 respectively, and preparing the granule into high, medium and low dosage groups with concentration of 1.2g crude drug/kg, 0.6g crude drug/kg and 0.3g crude drug/kg by distilled water;
(2) Taking the granules prepared from the traditional Chinese medicine compositions in comparative examples 1-18, and preparing a solution with the concentration of 0.6g crude drug/kg by distilled water;
2. model preparation
The rats were fasted for 8 hours before surgery, and a facial nerve squeezing injury mode was selected to establish a model of peripheral facial paralysis of the rats. Anesthesia was given by intraperitoneal injection with 10% chloral hydrate (0.35 mL/100 g), and after the anesthesia was effected, the mice were fixed to the rat plates and the right cheek and chest abdomen were sheared to prepare skins. After skin preparation is completed, 75% alcohol is used for conventional disinfection, a towel is spread, a position which is about 1cm below a pupil and is connected with a mouth corner in front of a right ear screen is cut by a surgical knife at the cheek part (between the mouth corner and the ear screen) of a rat, and then a hemostatic forceps is used for slowly and passively separating subcutaneous tissues at the position and exposing facial nerve upper cheek branches; the facial nerve upper cheek branch is clamped by the mosquito hemostatic forceps, the clamping is carried out for 30 seconds, the skin is sewn layer by layer, and the surrounding skin is sterilized. Molding success standard: after the SD rat is molded, the symptoms of edema and thickened squeezing injury of the upper cheek expenditure of the right side nerve can be seen, and compared with the left side without injury, the blink reflex on the right side is disappeared, and the tentacle direction is changed from vertical to backward, so that tentacle movement is disappeared.
3. Grouping and administration
(1) Influence on blink reflection, tentacle direction and tentacle movement function of rats after facial paralysis
Several healthy male SD rats were taken, weighing 200g-250g, 10 per group, wherein:
group 1 is blank group, and is fed normally without treatment;
group 2 is a model control group, and no drug is given after the model is made;
the 3 groups are positive control groups, and the prednisone acetate is 0.004g/kg after molding;
4. after 20 sets of moulds, the stomach was irrigated respectively with example 1 and example 3 (0.6 g/kg);
5. and 6, respectively filling the stomach after the molding is performed on the components 6 and 7: the high, medium and low doses (1.2 g crude drug/kg, 0.6g crude drug/kg, 0.3g crude drug/kg) of the granules in example 1 of the present invention;
8-19 groups of the granule solutions (0.6 g crude drug/kg) in comparative examples 1-12 were respectively filled with stomach after molding;
21. and (2) respectively filling the stomach after 22 and 23 groups of moulds: the high, medium and low doses (1.2 g crude drug/kg, 0.6g crude drug/kg, 0.3g crude drug/kg) of the granules in example 3 of the present invention;
and (3) respectively carrying out gastric lavage treatment after 24-29 groups of moulds: 13-18 prescription of medicine (0.6 g crude drug/kg).
For a total of 14d, 1 time per day, the recovery of facial nerve function on the right side of the rats was compared to the left side of the rats, and observed and recorded for 14 days. Each rat was evaluated for blink reflex, tentacle movement, and tentacle direction recovery using a 3 point metric daily (1 point: no recovery; 2 points: partial recovery; 3 points: full recovery). The experimental method comprises the following steps: the movement of the rat eyelid, the closure state and the movement of the beard were observed and recorded and scored by instantaneous blowing 2mL with a 5mL syringe fitted with an 18 gauge needle 3cm from the eyes of the experimental animal. Complete recovery was determined when all facial nerve parameters reached 3 minutes per rat. The blink reflex, tentacle movement and tentacle direction conditions of rats after 1d, 7d, 14d of treatment are shown in tables 1-3.
Table 1 results of scoring blink reflex, tentacle movement and tentacle direction in rats 1 day after treatment (n=10)
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Table 2 results of blink reflex, tentacle movement and tentacle direction scoring of rats after 7 days of treatment (n=10)
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Table 3 results of blink reflex, tentacle movement and tentacle direction scoring of rats after 14 days of treatment (n=10)
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(note: compared to before molding, # p is less than 0.05; p <0.05 compared to model group<0.01)
As can be seen from the results in the table, as can be seen from the table 1, the difference of the behavioral score before and after molding is obvious (P < 0.01), and the difference has statistical significance, which indicates that the molding is successful. Compared with a model group, the medicinal composition particles can effectively treat peripheral facial paralysis and shorten the recovery time of symptoms after facial paralysis. After the molding of the rat is completed, peripheral facial paralysis is presented, including blink reflex loss, tentacle movement disappearance, tentacle direction change from vertical to backward, and the like. After 7 days of treatment, the three dosage groups of the low, medium and high particles of the pharmaceutical composition show the trend of promoting the recovery of the blink reflex function faster than the tentacle direction and the tentacle movement and the recovery of the functions of each treatment group faster than the model group, which suggests that the particles of the pharmaceutical composition of the invention can promote the recovery of the blink reflex faster than the tentacle direction and the tentacle movement in the aspect of improving the symptoms of the SD rats in the initial stage of treatment, and the recovery of the symptoms of the rats in the treatment group is better than that of the model group. After 14 days of treatment, the individual scores of blink reflex, tentacle direction and tentacle movement of each treatment group are superior to those of a model group, and in terms of the individual scores, blink reflex scores of the high-dose group and the positive drug group in the drug composition particles are remarkably higher than those of the model group, tentacle direction scores of the high-dose group and the positive drug group in the drug composition particles are remarkably higher than those of the model group, and tentacle movement scores of the high-dose group in the drug composition particles are remarkably higher than those of the model group. The three dosage groups of the medicine composition of the invention with low, medium and high particles have no statistical difference in blink reflex, tentacle direction and tentacle movement score compared with the positive medicine group. After rats are treated for 14 days, the total scores of the three low, medium and high dose groups and the positive drug group of the drug composition particles are obviously superior to those of a model group, and the scores of the medium and high dose groups of the drug composition particles are not obviously different from those of the positive drug group. The research result shows that the medicine composition particles have good effect of treating peripheral facial paralysis, and can obviously promote the recovery of blink reflection, tentacle direction and tentacle movement function of model rats after facial paralysis.
(2) Influence on lip microcirculation blood perfusion after facial paralysis of rats
The detection is carried out by a laser Doppler tissue blood flow instrument before molding and after administration treatment, namely 1, 7 and 14 d. The rats were anesthetized by 10% chloral hydrate 0.35mL/100g intraperitoneal injection, and after complete anesthesia and respiratory calm, were placed in a supine position, and maintained at a gentle temperature and with a steady body, and a Doppler probe was placed on the lip of the rat, and the average value of the blood flow velocity [ mL/min. Kg ] within 1min was measured, and the results are shown in Table 4.
TABLE 4 changes in blood flow velocity on the molding side of rats [ mL/(min. Kg) ] (X.+ -. S, n=10)
(note: compared to before molding, # p is less than 0.05; comparing with model group, P <0.05<0.01)
As can be seen from the results in the table, the difference in blood flow velocity between the lips on the molding side was remarkable (P < 0.05) as compared with the front and rear molding of each group of molds as seen from Table 2. With the progress of treatment, the drug treatment groups were reduced to different degrees after 1 and 2 weeks of treatment, and the reduction was significant (P < 0.05) compared to the model of the model group; after 2 weeks of treatment, there was no significant difference (P > 0.05) from before and after the modeling.
The results show that the medicine composition of the invention has different formulas and high, medium and low dosage of granule, and can obviously improve the effect of facial nerve injury, but the prescription removing effect is obviously inferior to the full prescription.
The blood flow velocity of the model side of the traditional Chinese medicine composition is obviously superior to that of the model group in the high, medium and low dose groups and the positive medicine group, and the composition has no significance (P > 0.05) in the medium and high dose groups compared with the positive medicine group.
The research result shows that the traditional Chinese medicine composition has good effect of treating peripheral facial paralysis, can promote blink reflection after facial paralysis occurs in a model rat, restore tentacle direction and tentacle movement function, and remarkably improve blood flow velocity.
The laser Doppler perfusion imager PeriScan PIM II system is adopted to observe the microcirculatory blood flow perfusion change of the right lip of the experimental rat, the result is shown in figures 1 to 3, the red area in the figure shows that the blood flow perfusion is rich, the yellow and green areas show that the blood flow perfusion is slightly worse, and the blue area shows that the blood flow perfusion is poor. FIG. 1 is a graph showing lip blood perfusion of rats in blank, model, positive and example 3, 7 days and 14 days of gavage with the Chinese medicinal composition; FIG. 2 is a diagram showing perfusion of lip blood of high, medium and low dose groups of rats in example 3; FIG. 3 is a graph showing perfusion of lips of rats with the Chinese medicinal composition of comparative examples 13-18 for 7 days and 14 days. Comparing fig. 1 to 3, it can be seen that the traditional Chinese medicine composition prepared by the invention has good effect of treating peripheral facial paralysis and positive improvement effect on blood perfusion of the lips of rats.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (9)
1. A traditional Chinese medicine composition for treating peripheral facial paralysis is characterized in that: the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
15-25 parts of honeysuckle, 7-15 parts of weeping forsythiae capsule, 8-15 parts of wild chrysanthemum flower, 7-15 parts of radix isatidis, 8-18 parts of cicada slough, 10-18 parts of scorpion, 8-16 parts of stiff silkworm, 10-18 parts of centipede, 8-15 parts of large-leaf gentian root, 4-12 parts of radix bupleuri, 4-12 parts of notopterygium root, 4-12 parts of radix angelicae pubescentis, 15-25 parts of kudzuvine root, 5-10 parts of divaricate saposhnikovia root, 5-10 parts of dahurian angelica root, 10-20 parts of stir-fried white paeony root, 4-12 parts of cassia twig, 5-15 parts of Chinese angelica, 4-12 parts of szechuan lovage rhizome, 2-10 parts of asarum, 8-15 parts of white atractylodes rhizome, 15-25 parts of astragalus root, 10-20 parts of Indian buead and 3-10 parts of liquorice.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
17-25 parts of honeysuckle, 10-15 parts of weeping forsythiae capsule, 10-15 parts of wild chrysanthemum flower, 9-15 parts of radix isatidis, 10-16 parts of cicada slough, 10-16 parts of scorpion, 10-15 parts of stiff silkworm, 10-16 parts of centipede, 10-14 parts of large-leaf gentian root, 7-10 parts of radix bupleuri, 7-10 parts of notopterygium root, 7-10 parts of radix angelicae pubescentis, 17-25 parts of kudzuvine root, 7-10 parts of divaricate saposhnikovia root, 7-10 parts of dahurian angelica root, 10-15 parts of stir-fried white paeony root, 5-10 parts of cassia twig, 5-10 parts of Chinese angelica, 5-10 parts of szechuan lovage rhizome, 3-5 parts of manchurian wildginger, 10-14 parts of largehead atractylodes rhizome, 16-20 parts of astragalus root, 11-15 parts of Indian buead and 5-9 parts of liquorice.
3. The traditional Chinese medicine composition according to claim 2, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight:
18 parts of honeysuckle, 10 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 12 parts of radix isatidis, 14 parts of cicada slough, 14 parts of scorpion, 13 parts of stiff silkworm, 14 parts of centipede, 12 parts of gentiana macrophylla, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of radix puerariae, 7 parts of radix sileris, 7 parts of radix angelicae, 10 parts of fried radix paeoniae alba, 7 parts of cassia twig, 7 parts of angelica sinensis, 7 parts of ligusticum wallichii, 3 parts of asarum, 12 parts of bighead atractylodes rhizome, 18 parts of astragalus, 13 parts of poria cocos and 5 parts of liquorice;
or 17 parts of honeysuckle, 10 parts of weeping forsythia, 10 parts of wild chrysanthemum flower, 9 parts of radix isatidis, 10 parts of cicada slough, 10 parts of scorpion, 10 parts of stiff silkworm, 10 parts of centipede, 10 parts of large-leaf gentian root, 8 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 17 parts of kudzuvine root, 8 parts of radix sileris, 8 parts of angelica dahurica, 10 parts of stir-fried white paeony root, 5 parts of cassia twig, 5 parts of angelica sinensis, 5 parts of szechuan lovage rhizome, 3 parts of asarum, 10 parts of bighead atractylodes rhizome, 16 parts of astragalus root, 11 parts of poria cocos and 5 parts of liquorice;
or 20 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 10 parts of radix isatidis, 12 parts of cicada slough, 12 parts of scorpion, 12 parts of stiff silkworm, 12 parts of centipede, 10 parts of gentiana macrophylla, 9 parts of radix bupleuri, 9 parts of notopterygium root, 9 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 8 parts of divaricate saposhnikovia root, 9 parts of dahurian angelica root, 12 parts of stir-fried white paeony root, 6 parts of cassia twig, 6 parts of Chinese angelica, 6 parts of szechuan lovage rhizome, 3 parts of manchurian wildginger, 10 parts of largehead atractylodes rhizome, 16 parts of astragalus root, 12 parts of Indian buead and 5 parts of liquorice;
or 22 parts of honeysuckle, 12 parts of weeping forsythia, 12 parts of wild chrysanthemum flower, 11 parts of radix isatidis, 13 parts of cicada slough, 13 parts of scorpion, 13 parts of stiff silkworm, 13 parts of centipede, 10 parts of large-leaf gentian root, 7 parts of radix bupleuri, 7 parts of notopterygium root, 7 parts of radix angelicae pubescentis, 20 parts of kudzuvine root, 7 parts of radix sileris, 7 parts of angelica dahurica, 10 parts of stir-fried white paeony root, 7 parts of cassia twig, 7 parts of angelica, 7 parts of szechuan lovage rhizome, 3 parts of asarum, 10 parts of bighead atractylodes rhizome, 16 parts of astragalus root, 11 parts of poria cocos and 5 parts of liquorice;
or 25 parts of honeysuckle, 15 parts of weeping forsythia, 15 parts of wild chrysanthemum flower, 15 parts of radix isatidis, 16 parts of cicada slough, 16 parts of scorpion, 15 parts of stiff silkworm, 16 parts of centipede, 14 parts of gentiana macrophylla, 10 parts of radix bupleuri, 10 parts of notopterygium root, 10 parts of radix angelicae pubescentis, 25 parts of kudzuvine root, 10 parts of radix sileris, 10 parts of angelica dahurica, 15 parts of stir-fried white peony root, 10 parts of cassia twig, 10 parts of angelica, 10 parts of szechuan lovage rhizome, 5 parts of asarum, 14 parts of bighead atractylodes rhizome, 20 parts of astragalus, 15 parts of poria cocos and 9 parts of liquorice.
4. A traditional Chinese medicine composition according to any one of claims 1 to 3, wherein said traditional Chinese medicine composition is in any pharmaceutically acceptable dosage form.
5. The pharmaceutical composition of claim 4, wherein the pharmaceutically acceptable dosage form is a granule, an oral solution, a tablet, a capsule, or a pill.
6. A method of preparing a Chinese medicinal composition according to any one of claims 1 to 5, comprising the steps of:
a) Soaking flos Lonicerae, fructus forsythiae, notopterygii rhizoma, radix Angelicae Pubescentis, ramulus Cinnamomi, radix Saposhnikoviae, radix Gentianae Marcrophyllae, bupleuri radix, radix Angelicae sinensis, rhizoma Ligustici Chuanxiong, herba asari, and Atractylodis rhizoma in water for 1-3 hr, extracting volatile oil by steam distillation, and collecting volatile oil; collecting distilled water solution in another container;
b) Mixing the residue after extracting volatile oil with the rest materials, decocting with water for 1-3 times, each for 1-3 hr, mixing filtrates, filtering, and mixing the filtrate with the water solution distilled in step A to obtain extractive solution;
c) Concentrating the extracting solution to obtain a concentrated solution; the relative density of the concentrated solution at 60 ℃ is 1.10-1.20;
d) Mixing the concentrated solution in the step C with ethanol until the alcohol content is 60% -70%, and performing alcohol precipitation to obtain an alcohol precipitation supernatant;
e) Concentrating the supernatant at 40-60deg.C to obtain fluid extract with relative density of 1.10-1.30;
f) E, freeze-drying the clear paste obtained in the step E to obtain dry paste;
g) Clathrating the volatile oil collected in the step A by adopting a saturated aqueous solution method to obtain a volatile oil clathrate;
h) And D, crushing the dry paste obtained in the step F, and then uniformly mixing the dry paste with the volatile oil inclusion compound obtained in the step G and a proper amount of auxiliary materials to obtain a target product, namely the traditional Chinese medicine composition.
7. The method of claim 6, wherein the time for extracting the volatile oil in the step A) is 4-6 hours.
8. The method for preparing a pharmaceutical composition according to claim 6, wherein the mass ratio of water to the total amount of each raw material in the step B) is 6-15.
9. The method for preparing a Chinese medicinal composition according to claim 6, wherein the freeze-drying temperature is-80 ℃ to-60 ℃.
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