CN117084252A - 一种含丙硫菌唑和福美双的杀菌组合物及其应用 - Google Patents
一种含丙硫菌唑和福美双的杀菌组合物及其应用 Download PDFInfo
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
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- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/26—Oxidation products of dithiocarbamic acid derivatives, e.g. thiuram sulfides
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
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Abstract
本发明提供了一种含丙硫菌唑和福美双的杀菌组合物,包含活性成分和增效剂,其中活性成分由丙硫菌唑和福美双组成,丙硫菌唑和福美双的质量配比为1:5‑5:1;增效剂为水杨酸、草酸或柠檬酸中的一种或多种。本发明的杀菌组合物具有显著的增效作用,并且组合物中添加增效剂(水杨酸、草酸、柠檬酸)可以显著提升药剂对小麦赤霉病和小麦白粉病的防治效果,有效降低活性成分的使用剂量,减缓病菌抗药性的产生,降低环境污染、保证食品安全。
Description
技术领域
本发明涉及农药技术领域,尤其是涉及一种含丙硫菌唑和福美双的杀菌组合物及其应用。
背景技术
长期以来,化学农药的不合理使用带来了农产品中农药残留超标、生态环境污染、有害生物抗药性发生和人类健康受到威胁等一系列难以解决的问题。同时,由于新农药的合成耗资多,风险大,周期长,难以在短期内满足人们对高效、安全农药的需求。农药增效组合物和农药剂型的研究,是农药发展的重要方面,增效组合物能降低农药用量,适宜的农药制剂能方便农药的使用,减少对于环境的影响。
丙硫菌唑为***硫酮类杀菌剂,属甾醇脱甲基化(麦角甾醇的生物合成)抑制剂。具有选择性、保护性、治疗性和持效性等特点。福美双是一种硫代氨基甲酸酯类杀菌剂,保护与治疗双重功效合二为一,有效成分随载体运转,深入病组织及菌体内部,起到良好的杀菌作用。广东中迅农科股份有限公司(201210119920.6)公开了一种含有丙硫菌唑和福美双的农药组合物,丙硫菌唑和福美双的重量份数比例为1:30-20:1,可用于防治黄瓜炭疽病的防治;并没有公开对于其他作物病害,特别是小麦赤霉病、白粉病的防治效果。
发明内容
本发明的目的在于提供一种具有显著增效作用的杀菌组合物,本发明另一目的在于组合物中通过添加适宜增效剂提升药剂防效。
本发明提供如下技术方案:
一种含丙硫菌唑和福美双的杀菌组合物,其特征在于,包含活性成分和增效剂,其中活性成分由丙硫菌唑和福美双组成,丙硫菌唑和福美双的质量配比为1:5-5:1;增效剂为水杨酸、草酸或柠檬酸中的一种或多种。
优选的,丙硫菌唑和福美双的质量配比为4:1-2:1。特别优选的,丙硫菌唑和福美双的质量配比为3:1。
优选的,增效剂由草酸和柠檬酸组成,草酸和柠檬酸的质量配比为1:3-3:1。特别优选的,草酸和柠檬酸的质量配比为1:1。
所述杀菌组合物的制剂为悬浮剂,还包含农业上辅料成分。
优选为:40%丙·福悬浮剂,包含如下重量百分含量的成分:丙硫菌唑25%、福美双15%、草酸1.5%、柠檬酸1.5%、十二烷基苯磺酸钠2%、Ethylan NS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
所述的杀菌组合物用于小麦赤霉病和小麦白粉病防治的用途。
采用上述技术方案,本发明具有如下有益效果:
本发明的杀菌组合物具有显著的增效作用,并且组合物中添加增效剂(水杨酸、草酸、柠檬酸)可以显著提升药剂对小麦赤霉病和小麦白粉病的防治效果,有效降低活性成分的使用剂量,减缓病菌抗药性的产生,降低环境污染、保证食品安全。
具体实施方式
基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
下面结合具体的实施方式对本发明做进一步的解释说明。
实施例1丙硫菌唑和福美双复配对小麦赤霉病的联合作用测试
供试菌株:小麦赤霉病病菌(Fusarium graminearum),田间采集,实验室鉴定培养保存备用。
供试药剂:丙硫菌唑原药和福美双原药
试验方法:采取菌丝生长速率法对小麦赤霉病的室内毒力测定。根据预试验结果选择7个药剂浓度梯度,将配制好的供试药剂按比例加入灭菌冷却至55℃的PDA培养基,充分摇匀后倒入9cm的灭菌培养皿中,待其凝固接入5mm菌饼,每处理设4次重复,封口后置于28℃恒温箱培养。5d后采用十字交叉法测定菌落直径,计算菌丝生长抑制率。
菌丝生长抑制率=(对照菌落生长直径-处理菌落生长直径)(/对照菌落生长直径-菌饼直径)×100%。
将菌落的生长抑制率换算成抑制几率作为因变量(y),各药剂浓度(mg/L)转为以10为底的对数值(x),并用DPS软件求出各供试药剂的有效抑制中浓度EC50。
依据孙云沛法,计算复配剂实际毒力指数(ATI)、理论毒力指数(TTI)和共毒系数(CTC),评价增效作用、确定最佳配比。
单剂毒力指数=(标准药剂的EC50/某单剂EC50)×100;
理论毒力指数(TTI)=A单剂的毒力指数×A单剂在混剂中所占比例+B单剂的毒力指数×B单剂在混剂中所占比例;
实测毒力指数(ATI)=(标准单剂的EC50值/混剂的EC50值)×100;
共毒系数(CTC)=(实测毒力指数/理论毒力指数)×100;
CTC大于120时混剂具有协同增效作用,CTC小于80时为拮抗,CTC在80-120之间为相加作用。
结果与分析:
由表1可知,丙硫菌唑和福美双对小麦赤霉病具有优异的防治效果,其EC50值分别为6.5618和13.4205mg/L。当丙硫菌唑和福美双质量配比为3:1时,复配组合物对对小麦赤霉病表现为显著的增效作用,CTC值为138.2。当组合物表现为协同增效作用时,可以有效降低活性成分的使用剂量,减缓病菌抗药性的产生。
表1丙硫菌唑和福美双复配对小麦赤霉病的联合作用
实施例2制剂配方
供试材料:丙硫菌唑原药、福美双原药、十二烷基苯磺酸钠、Ethylan NS 500LQ、Agrlian-700、乙二醇、苯甲酸钠、硅酸镁铝、黄原胶、有机膨润土、增效剂(水杨酸、草酸、柠檬酸)、二甲基硅油、去离子水。
主要实验仪器:电子天平、CX31型显微镜、JL-1156激光粒度分布测试仪、砂磨机等
制备方法:将原药,辅料按照一定的比例,以水为分散介质混合并进行湿法超细粉碎而制备的农药剂型。在进行研磨时,需向混合物中加入氧化锆珠,其比重为悬浮剂自身重量的2倍。在室温下以1200r/min的速率高速研磨,将悬浮剂平均粒径减小至小于5μm,可以在分离锆珠之后获得农药悬浮剂。
具体配方如下:
配方1:40%丙·福悬浮剂,包含如下重量百分含量的成分:
丙硫菌唑25%、福美双15%、增效剂(水杨酸)3%、十二烷基苯磺酸钠2%、EthylanNS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
配方2:40%丙·福悬浮剂,包含如下重量百分含量的成分:
丙硫菌唑25%、福美双15%、增效剂(草酸)3%、十二烷基苯磺酸钠2%、EthylanNS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
配方3:40%丙·福悬浮剂,包含如下重量百分含量的成分:
丙硫菌唑25%、福美双15%、增效剂(柠檬酸)3%、十二烷基苯磺酸钠2%、EthylanNS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
配方4:40%丙·福悬浮剂,包含如下重量百分含量的成分:
丙硫菌唑25%、福美双15%、增效剂(水杨酸+草酸质量比=1:1)3%、十二烷基苯磺酸钠2%、Ethylan NS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
配方5:40%丙·福悬浮剂,包含如下重量百分含量的成分:
丙硫菌唑25%、福美双15%、增效剂(水杨酸+柠檬酸质量比=1:1)3%、十二烷基苯磺酸钠2%、Ethylan NS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
配方6:40%丙·福悬浮剂,包含如下重量百分含量的成分:
丙硫菌唑25%、福美双15%、增效剂(草酸+柠檬酸质量比=1:1)3%、十二烷基苯磺酸钠2%、Ethylan NS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
配方740%丙·福悬浮剂,包含如下重量百分含量的成分:
丙硫菌唑25%、福美双15%、十二烷基苯磺酸钠2%、Ethylan NS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
实施例3 40%丙·福悬浮剂对小麦赤霉病的田间防效测试
测试作物:小麦
作物病害:赤霉病
测试药剂:配方1-7
测试方法:小麦赤霉病:参照中华人民共和国行业标准NY/T1464.15-2007《农药田间药效试验准则第15部分:杀菌剂防治小麦赤霉病》,在冬麦田进行,扬花初期首次施药,间隔7d第二次施药,共施药2次,用水量30L/亩,调查时间为第二次药后21d。
结果与分析
40%丙·福悬浮剂中添加增效剂(水杨酸、草酸、柠檬酸)可以显著提升丙硫菌唑和福美双复配悬浮剂对小麦赤霉病的防治效果;并且增效剂为草酸和柠檬酸组合后,在相同用量下,对小麦赤霉病的防效为96.54%,可以显著降低活性成分的田间用药量,降低环境污染、保证食品安全。
表2 40%丙·福悬浮剂对小麦赤霉病的田间防效
实施例440%丙·福悬浮剂对小麦白粉病的田间防效测试
测试作物:小麦
作物病害:白粉病
测试药剂:配方1-7
测试方法:选择大田小麦白粉病发病初期进行喷雾处理,进行2次喷雾,时间间隔为7d,施药时间约为4月下旬,用水量为30L/亩。
调查时间:分别于药前进行病情基数调查,2次药后14d,进行防效调查;调查方法:每小区5点取样,每点调查20株小麦,进行病害分级。
小麦白粉病发病情况分级:0级:无病;1级:病斑面积占整叶片面积的5%以下;3级:病斑面积占整叶片面积的6%-15%;5级:病斑面积占整叶片面积的16%-25%;7级:病斑面积占整叶片面积的26%-50%;9级:病斑面积占整叶片面积的50%以上。
计算公式:
式中:CK0为空白对照区施药前病情指数;CK1为空白对照区施药后病情指数;PT0为药剂处理区施药前病情指数;PT1为药剂处理区施药前病情指数。
结果与分析
40%丙·福悬浮剂中添加增效剂(水杨酸、草酸、柠檬酸)可以显著提升丙硫菌唑和福美双复配悬浮剂对小麦白粉病的防治效果;并且增效剂为草酸和柠檬酸组合后,在相同用量下,对小麦白粉病的防效为94.97%,可以显著降低活性成分的田间用药量,降低环境污染、保证食品安全。
表340%丙·福悬浮剂对小麦白粉病的田间防效
最后应说明的是:以上各实施例仅用以说明本发明的技术方案,而非对其限制。
Claims (9)
1.一种含丙硫菌唑和福美双的杀菌组合物,其特征在于,包含活性成分和增效剂,其中活性成分由丙硫菌唑和福美双组成,丙硫菌唑和福美双的质量配比为1:5-5:1;增效剂为水杨酸、草酸或柠檬酸中的一种或多种。
2.根据权利要求1所述的杀菌组合物,其特征在于,丙硫菌唑和福美双的质量配比为4:1-2:1。
3.根据权利要求2所述的杀菌组合物,其特征在于,丙硫菌唑和福美双的质量配比为3:1。
4.根据权利要求1所述的杀菌组合物,其特征在于,增效剂由草酸和柠檬酸组成,草酸和柠檬酸的质量配比为1:3-3:1。
5.根据权利要求4所述的杀菌组合物,其特征在于,草酸和柠檬酸的质量配比为1:1。
6.根据权利要求1-5任一项所述的杀菌组合物,其特征在于,杀菌组合物的制剂为悬浮剂。
7.根据权利要求6所述的杀菌组合物,其特征在于,还包含农业上辅料成分。
8.根据权利要求7所述的杀菌组合物,其特征在于,悬浮剂为40%丙·福悬浮剂,包含如下重量百分含量的成分:丙硫菌唑25%、福美双15%、草酸1.5%、柠檬酸1.5%、十二烷基苯磺酸钠2%、Ethylan NS 500LQ 3%、Agrlian-700 5%、乙二醇2%、苯甲酸钠0.5%、硅酸镁铝1%、黄原胶0.5%、有机膨润土1.5%、二甲基硅油0.5%、去离子水补足100%。
9.根据权利要求1-8任一项所述的杀菌组合物用于小麦赤霉病和小麦白粉病防治的用途。
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