CN117028619B - Switching valve for analysis device, exhaust method, and analysis device - Google Patents
Switching valve for analysis device, exhaust method, and analysis device Download PDFInfo
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- CN117028619B CN117028619B CN202311282457.1A CN202311282457A CN117028619B CN 117028619 B CN117028619 B CN 117028619B CN 202311282457 A CN202311282457 A CN 202311282457A CN 117028619 B CN117028619 B CN 117028619B
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- 238000004458 analytical method Methods 0.000 title claims abstract description 60
- 238000000034 method Methods 0.000 title claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 38
- 238000002347 injection Methods 0.000 claims abstract description 36
- 239000007924 injection Substances 0.000 claims abstract description 36
- 238000005070 sampling Methods 0.000 claims description 8
- 238000012544 monitoring process Methods 0.000 claims description 6
- 238000012742 biochemical analysis Methods 0.000 abstract description 2
- 239000003550 marker Substances 0.000 description 18
- 238000010586 diagram Methods 0.000 description 5
- 238000004811 liquid chromatography Methods 0.000 description 3
- 238000004891 communication Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
- F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
- F16K11/072—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members
- F16K11/074—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with pivoted closure members with flat sealing faces
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/02—Actuating devices; Operating means; Releasing devices electric; magnetic
- F16K31/04—Actuating devices; Operating means; Releasing devices electric; magnetic using a motor
- F16K31/041—Actuating devices; Operating means; Releasing devices electric; magnetic using a motor for rotating valves
- F16K31/042—Actuating devices; Operating means; Releasing devices electric; magnetic using a motor for rotating valves with electric means, e.g. for controlling the motor or a clutch between the valve and the motor
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K37/00—Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
- F16K37/0008—Mechanical means
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K37/00—Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
- F16K37/0075—For recording or indicating the functioning of a valve in combination with test equipment
- F16K37/0091—For recording or indicating the functioning of a valve in combination with test equipment by measuring fluid parameters
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/201—Injection using a sampling valve multiport valves, i.e. having more than two ports
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/202—Injection using a sampling valve rotary valves
Landscapes
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Multiple-Way Valves (AREA)
Abstract
The application relates to a switching valve for analysis equipment, an exhaust method and analysis equipment, and belongs to the technical field of biochemical analysis equipment, wherein the switching valve comprises a stator and a rotor, a plurality of grooves are formed in the end face of the rotor, which faces the stator, a plurality of through holes are formed in the stator, and the switching valve is switched among a loading state, a sample injection state and an exhaust state according to the rotation position of the rotor; when the switching valve is in the exhaust state, the groove and the through hole are at least formed with an exhaust liquid path. According to the switching valve, the exhaust method and the analysis equipment for the analysis equipment, the switching valve does not need to be externally connected with an exhaust valve, loading, sample introduction and exhaust functions can be achieved through the switching valve, the liquid path pressure is monitored in real time through the externally connected pressure sensor, the fact that the pressure is low indicates that bubbles exist, after the control system judges that the bubbles exist, the switching valve is controlled to be in an exhaust state to exhaust the bubbles, the exhaust difficulty of the switching valve is reduced, and the working efficiency of the analysis equipment is improved.
Description
Technical Field
The present application relates to the field of biochemical analysis equipment, and in particular, to a switching valve for an analysis apparatus, an exhaust method, and an analysis apparatus.
Background
The switching valve belongs to rotary flow channel switching, and the connecting piece is driven to switch the flow channel through motor rotation, so that the flow channels are positioned to different channels to realize communication. In the prior art, liquid chromatography equipment adopts a pump to carry out transfusion, bubbles possibly occur in liquid conveyed by the pump, in order to avoid the bubbles entering into a switching valve, the liquid chromatography equipment generally adds a manually-controlled two-position one-way high-pressure exhaust switching valve on the switching valve, when bubbles occur in a liquid path, a system can send out warning errors after detecting pressure changes, at the moment, an exhaust valve needs to be opened manually, and the system is closed after the bubbles are exhausted. The exhaust method of the switching valve has the advantages of complex structure, complicated exhaust operation and high cost, increases the operation difficulty of the switching valve, and reduces the working efficiency of the liquid chromatography analysis equipment.
Disclosure of Invention
Based on this, it is necessary to provide a switching valve for an analysis device, an exhaust method and an analysis device, so as to solve the technical problems of complex structure, complicated exhaust operation and high cost of the exhaust method of the switching valve in the prior art.
To this end, according to an aspect of the present application, there is provided a switching valve for an analysis apparatus, the switching valve including a stator and a rotor rotatable relative to the stator, a plurality of grooves being provided on an end face of the rotor facing the stator, a plurality of through holes being provided on the stator corresponding to the plurality of grooves, the switching valve switching between a loading state, a sampling state, and an exhaust state according to a rotational position of the rotor;
when the switching valve is in a loading state, the groove and the through hole are at least provided with a loading liquid path;
when the switching valve is in a sample injection state, at least a sample injection liquid path is formed between the groove and the through hole;
when the switching valve is in the exhaust state, the groove and the through hole are at least formed with an exhaust liquid path.
Optionally, a first circular contour line is arranged on the end face of the rotor, facing the stator, the first circular contour line is provided with a first circle center, a first identification point, a second identification point, a third identification point, a fourth identification point, a fifth identification point and a sixth identification point which are used for equally dividing the first circular contour line are sequentially arranged on the first circular contour line, a linear groove, a first arc groove and a second arc groove are arranged on the rotor, two ends of the linear groove respectively correspond to the first circle center and the first identification point of the first circular contour line, two ends of the first arc groove respectively correspond to the second identification point and the third identification point, and two ends of the second arc groove respectively correspond to the fourth identification point and the fifth identification point.
Optionally, a second circular contour line is arranged on the end face, facing the rotor, of the stator, corresponding to the first circular contour line, the second circular contour line is provided with a second circle center, a first mark point, a second mark point, a third mark point, a fourth mark point, a fifth mark point and a sixth mark point which are used for equally dividing the second circular contour line are sequentially arranged on the second circular contour line, and a first through hole pointing to the first mark point, a second through hole pointing to the second mark point, a third through hole pointing to the third mark point, a fourth through hole pointing to the fourth mark point, a fifth through hole pointing to the fifth mark point, a sixth through hole pointing to the sixth mark point and a seventh through hole pointing to the second circle center are arranged on the stator.
Optionally, the switching valve is externally connected with a sample injection ring, and two ends of the sample injection ring are respectively connected with the first through hole and the fourth through hole;
the switching valve is externally connected with a pump body which is connected with the second through hole;
the switching valve is externally connected with a column tube which is connected with the third through hole;
the switching valve is externally connected with a sampling tube which is connected with the fifth through hole;
the switching valve is externally connected with a discharge pipe which is connected with the seventh through hole.
Optionally, when the switching valve is in the loading state, the linear groove is communicated with the first through hole and the seventh through hole, the first arc-shaped groove is communicated with the second through hole and the third through hole, and the second arc-shaped groove is communicated with the fourth through hole and the fifth through hole.
Optionally, when the switching valve is in the sample injection state, the linear groove is communicated with the sixth through hole and the seventh through hole, the first arc-shaped groove is communicated with the first through hole and the second through hole, and the second arc-shaped groove is communicated with the third through hole and the fourth through hole.
Optionally, when the switching valve is in the exhaust state, the linear groove is communicated with the second through hole and the seventh through hole, the first arc-shaped groove is communicated with the third through hole and the fourth through hole, and the second arc-shaped groove is communicated with the fifth through hole and the sixth through hole.
Optionally, the second through hole connected with the pump body is at a high pressure position, and the seventh through hole connected with the discharge pipe is at a low pressure position.
According to another aspect of the present application, there is provided a switching valve exhausting method for an analysis apparatus, which is applied to a switching valve for an analysis apparatus as described above, the exhausting method comprising the steps of:
monitoring whether bubbles appear in a liquid path of the switching valve in real time, monitoring the pressure of the sample injection liquid path by the switching valve through an external pressure sensor in real time, and indicating that the bubbles appear in the sample injection liquid path if the pressure is lower;
when the occurrence of bubbles in the liquid path is monitored, the switching valve is switched to an exhaust state, and an exhaust liquid path is formed in the switching valve in the exhaust state;
the bubbles are discharged out of the switching valve through the exhaust liquid path;
when the bubbles are detected to be completely discharged out of the switching valve, the switching valve is sequentially switched to a loading state and a sample injection state.
According to another aspect of the present application, there is provided an analysis apparatus comprising a switching valve for an analysis apparatus as described above.
Compared with the prior art, the switching valve has the beneficial effects that the switching valve does not need an external exhaust valve, the loading, sample introduction and exhaust functions can be realized through the switching valve, whether bubbles appear in a liquid path can be monitored in real time, and the switching valve can be automatically switched to an exhaust state to exhaust the bubbles after the bubbles appear, so that the exhaust difficulty of the switching valve is reduced; meanwhile, the automatic valve control system with high efficiency, reliability, stability and simplicity and convenience in operation is provided for the analysis equipment, the problems of complex structure, complex exhaust operation and low analysis efficiency of the analysis equipment are solved, and the working efficiency of the analysis equipment is improved.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described below, it being obvious that the drawings in the following description are only some embodiments of the present application, and that other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of an explosion structure of a switching valve for an analysis device according to an embodiment of the present disclosure;
fig. 2 is a schematic top view of a rotor of a switching valve for an analysis apparatus according to an embodiment of the present disclosure;
fig. 3 is a schematic bottom view of a stator of a switching valve for an analysis device according to an embodiment of the present disclosure;
FIG. 4 is a schematic diagram of a switching valve for an analysis device according to an embodiment of the present disclosure in a loading state;
fig. 5 is a schematic diagram of a switching valve for an analysis device in a sample injection state according to an embodiment of the present disclosure;
FIG. 6 is a schematic diagram of a switching valve for an analysis device according to an embodiment of the present disclosure in an exhaust state;
FIG. 7 is a schematic flow chart of a method for exhausting a switching valve for an analytical device according to an embodiment of the present disclosure;
fig. 8 is a schematic workflow diagram of an analysis device according to an embodiment of the present application.
Reference numerals illustrate:
1. a rotor; 101. a first circular contour; 102. a first center of a circle; 103. a first identification point; 104. a second identification point; 105. a third identification point; 106. a fourth identification point; 107. a fifth identification point; 108. a sixth identification point; 109. a linear groove; 110. a first arc-shaped groove; 111. a second arc-shaped groove;
2. a stator; 201. a second circular contour; 202. a second center of circle; 203. a first marker point; 204. a second marker point; 205. a third marker point; 206. a fourth marker point; 207. a fifth marker point; 208. a sixth marker point; 209. a first through hole; 210. a second through hole; 211. a third through hole; 212. a fourth through hole; 213. a fifth through hole; 214. a sixth through hole; 215. a seventh through hole;
3. a sample injection ring; 4. a pump body; 5. a column tube; 6. a sample delivery tube; 7. a discharge pipe;
8. a housing; 801. a receiving chamber.
Detailed Description
In order to make the above objects, features and advantages of the present application more comprehensible, embodiments accompanied with figures are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present application. This application is, however, susceptible of embodiment in many other forms than those described herein and similar modifications can be made by those skilled in the art without departing from the spirit of the application, and therefore the application is not to be limited to the specific embodiments disclosed below.
In the description of the present application, it should be understood that the terms "center," "longitudinal," "transverse," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," etc. indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be configured and operated in a particular orientation, and therefore should not be construed as limiting the present application.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" is at least two, such as two, three, etc., unless explicitly defined otherwise.
In this application, unless specifically stated and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the terms in this application will be understood by those of ordinary skill in the art as the case may be.
In this application, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or simply indicating that the first feature is less level than the second feature.
It will be understood that when an element is referred to as being "fixed" or "disposed" on another element, it can be directly on the other element or intervening elements may also be present. When an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and the like are used herein for illustrative purposes only and are not meant to be the only embodiment.
According to an aspect of the present application, referring to fig. 1 to 6 together, an embodiment of the present application provides a switching valve for an analysis apparatus, the switching valve includes a stator 2 and a rotor 1 capable of rotating relative to the stator 2, a plurality of grooves are disposed on an end surface of the rotor 1 facing the stator 2, a plurality of through holes are disposed on the stator 2 corresponding to the plurality of grooves, and the switching valve switches between a loading state, a sampling state and an exhaust state according to a rotation position of the rotor 1; when the switching valve is in a loading state, the groove and the through hole are at least provided with a loading liquid path; when the switching valve is in a sample injection state, at least a sample injection liquid path is formed between the groove and the through hole; when the switching valve is in the exhaust state, the groove and the through hole are at least formed with an exhaust liquid path.
In this application embodiment, the diverter valve of this application need not external discharge valve, can realize loading, advance appearance and exhaust function through self, and the diverter valve can whether have the bubble to appear in the real-time supervision liquid way, can automatic switch to the exhaust state after the bubble appears and come the bubble discharge, has reduced the exhaust degree of difficulty of diverter valve.
Meanwhile, the analysis equipment of the application provides an automatic valve control system which is high in efficiency, reliable and stable and simple and convenient to operate, solves the problems of complex structure, complex exhaust operation and low analysis efficiency of the analysis equipment, and improves the working efficiency of the analysis equipment.
Meanwhile, compared with manual valve control operation of experimenters, the full-automatic valve control program is integrated in the control software of the original analysis equipment, so that the accuracy and reliability of the analysis equipment are obviously improved; and the integrated software is simple and convenient to operate, no extra hardware is needed, and the analysis equipment can work even if not on duty, so that the workload of experiment operators is greatly reduced.
Specifically, referring to fig. 1, the switching valve further includes a housing 8, a housing 8 is provided with a housing cavity 801 having an opening at the top, and the rotor 1 is connected to a rotating shaft of the rotating electric machine, and the rotating electric machine drives the rotor 1 to rotate. The rotor 1 and the rotating electric machine are mounted together in the housing cavity 801, and the stator 2 is covered at the top opening of the housing 8 and fixed to the housing 8 by screws.
In one embodiment, referring to fig. 2, a first circular contour line 101 is disposed on an end surface of the rotor 1 facing the stator 2, the first circular contour line 101 has a first center 102, a first identification point 103, a second identification point 104, a third identification point 105, a fourth identification point 106, a fifth identification point 107 and a sixth identification point 108 which are formed by dividing the first circular contour line 101 into six equal parts are sequentially disposed on the first circular contour line 101, a linear groove 109, a first arc groove 110 and a second arc groove 111 are disposed on the rotor 1, two ends of the linear groove 109 respectively correspond to the first center 102 and the first identification point 103 of the first circular contour line 101, two ends of the first arc groove 110 respectively correspond to the second identification point 104 and the third identification point 105, and two ends of the second arc groove 111 respectively correspond to the fourth identification point 106 and the fifth identification point 107.
For example, referring to fig. 2, fig. 2 is a schematic top view of the rotor 1, and the first identification point 103, the second identification point 104, the third identification point 105, the fourth identification point 106, the fifth identification point 107, and the sixth identification point 108 are arranged on the first circular contour 101 in a clockwise direction.
In a specific embodiment, referring to fig. 3, a second circular contour 201 is disposed on an end surface of the stator 2 facing the rotor 1 corresponding to the first circular contour 101, the second circular contour 201 has a second center 202, a first mark point 203, a second mark point 204, a third mark point 205, a fourth mark point 206, a fifth mark point 207 and a sixth mark point 208 which are formed by dividing the second circular contour 201 into six equal parts are sequentially disposed on the second circular contour 201, and a first through hole 209, a second through hole 210, a third through hole 211, a fourth through hole 212, a fifth through hole 213, a sixth through hole 214 and a seventh through hole 215 which are formed by pointing to the first mark point 203, the second mark point 204, the third through hole 211, the fourth through hole 212, the fifth through hole 213, the sixth through hole 214 and the seventh through hole 215 are formed by pointing to the second center 202 are disposed on the stator 2.
Specifically, disposing the second circular contour 201 corresponding to the first circular contour 101 herein means that the first circular contour 101 and the second circular contour 201 are disposed coaxially. More specifically, the axis of the first circular contour line 101 and the axis of the second circular contour line 201 coincide with the axis of the rotating shaft of the rotating electrical machine.
For example, referring to fig. 3, fig. 3 is a schematic bottom view of the stator 2, where the first marker 203, the second marker 204, the third marker 205, the fourth marker 206, the fifth marker 207 and the sixth marker 208 are arranged along the second circular outline 201 in a counterclockwise direction, so that the first marker 203 corresponds to the first marker 103, the second marker 204 corresponds to the second marker 104, and the sixth marker 208 corresponds to the sixth marker 108.
Further, when the switching valve is set to be in any one of the loading state, the sample feeding state or the exhaust state, the first marking point 203 and the first marking point 103 are aligned, so that the control system can clearly and clearly determine which through holes on the stator 2 each groove on the rotor 1 is aligned with when the switching valve is in each state.
In one embodiment, referring to fig. 4 to fig. 6, the switching valve is externally connected with a sample ring 3, and two ends of the sample ring 3 are respectively connected to the first through hole 209 and the fourth through hole 212; the switching valve is externally connected with a pump body 4, and the pump body 4 is connected to the second through hole 210; the switching valve is externally connected with a column tube 5, and the column tube 5 is connected with a third through hole 211; the switching valve is externally connected with a sampling tube 6, and the sampling tube 6 is connected with a fifth through hole 213; the switching valve is externally connected with a discharge pipe 7, and the discharge pipe 7 is connected to the seventh through hole 215.
Wherein, the delivery pipe 6 and the discharge pipe 7 are both in a low-pressure environment, and the pump body 4 and the column pipe 5 are in a high-pressure environment.
In one embodiment, referring to fig. 4, when the switching valve is in the loading state, the linear groove 109 communicates with the first through hole 209 and the seventh through hole 215, the first arc groove 110 communicates with the second through hole 210 and the third through hole 211, and the second arc groove 111 communicates with the fourth through hole 212 and the fifth through hole 213.
Specifically, referring to fig. 4, the sample is injected into the fifth through hole 213 through the sample tube 6, and the sample further flows to the fourth through hole 212 because the second arc-shaped groove 111 communicates with the fourth through hole 212 and the fifth through hole 213; since both ends of the sample injection ring 3 are connected to the first through hole 209 and the fourth through hole 212, respectively, the sample further flows from the fourth through hole 212 to the first through hole 209 through the sample injection ring 3; since the linear groove 109 communicates the first through hole 209 and the seventh through hole 215, the sample may further flow to the seventh through hole 215; since the discharge pipe 7 is connected to the seventh through hole 215, the sample is further discharged from the seventh through hole 215 through the discharge pipe 7. In summary, when the discharge tube 7 is discharged with the sample, it is verified that the linear groove 109, the sample injection ring 3 and the second arc groove 111 are filled with the sample.
In one embodiment, referring to fig. 5, when the switching valve is in the sample injection state, the linear groove 109 communicates with the sixth through hole 214 and the seventh through hole 215, the first arc groove 110 communicates with the first through hole 209 and the second through hole 210, and the second arc groove 111 communicates with the third through hole 211 and the fourth through hole 212.
Referring to fig. 4 and 5, the rotor 1 of the switching valve in fig. 4 rotates clockwise by 60 ° to switch the switching valve from the loading state of fig. 4 to the sample feeding state of fig. 5.
Specifically, referring to fig. 5, the pump body 4 delivers high-pressure liquid to the second through hole 210; since the first arc-shaped slot 110 is communicated with the first through hole 209 and the second through hole 210, and both ends of the sample injection ring 3 are respectively connected with the first through hole 209 and the fourth through hole 212, and the second arc-shaped slot 111 is communicated with the third through hole 211 and the fourth through hole 212, a sample can flow from the second through hole 210 to the first through hole 209 through the first arc-shaped slot 110, then flow from the first through hole 209 to the fourth through hole 212 through the sample injection ring 3, and then flow from the fourth through hole 212 to the third through hole 211 through the second arc-shaped slot 111; since the vial 5 is connected to the third through-hole 211, the sample eventually enters the vial 5. In summary, after the switching valve is switched to the sample injection state, the pump body 4 will convey the sample in the sample injection ring 3 to the column tube 5 for detection.
It should be noted that the volume of the sample loop 3 is fixed, and the volume of the sample loop 3 is determined according to the concentration and the response value of the sample, so as to ensure that the sampling and the sample feeding amount are consistent each time, and further improve the accuracy of sample detection.
In one embodiment, referring to fig. 6, when the switching valve is in the exhaust state, the linear groove 109 communicates with the second through hole 210 and the seventh through hole 215, the first arc groove 110 communicates with the third through hole 211 and the fourth through hole 212, and the second arc groove 111 communicates with the fifth through hole 213 and the sixth through hole 214.
Referring to fig. 4 and 6 together, the rotor 1 of the switching valve in fig. 4 rotates counterclockwise by 60 °, so that the switching valve is switched from the loading state of fig. 4 to the exhaust state of fig. 6.
When bubbles appear in the liquid path of the pump body 4, the switching valve is in a venting state to vent the bubbles out of the switching valve. Specifically, since the linear groove 109 communicates the second through hole 210 and the seventh through hole 215, the pump body 4 is connected to the second through hole 210, and the discharge pipe 7 is connected to the seventh through hole 215, the bubbles are accompanied by the liquid from the second through hole 210 to the seventh through hole 215 through the linear groove 109, and then discharged out of the switching valve through the discharge pipe 7.
To sum up, the switching valve of this application need not external discharge valve, can realize loading, advance appearance and exhaust function through self, after the bubble appears in the liquid way, rotate rotor 1 and can make pump body 4 and discharge tube 7 intercommunication, just can conveniently, swiftly discharge the bubble, reduce the exhaust degree of difficulty of switching valve.
In one embodiment, the second through hole 210 connected with the pump body 4 is at a high pressure position, and the seventh through hole 215 connected with the discharge pipe 7 is at a low pressure position, so that bubbles can smoothly reach the discharge pipe 7 from the pump body 4, and the difficulty of air discharge is reduced.
In accordance with another aspect of the present application, referring to fig. 7, an embodiment of the present application further provides a method for exhausting a switching valve for an analysis apparatus, which is applied to the switching valve for an analysis apparatus as described above, the method comprising the steps of:
step S1: monitoring whether bubbles appear in a liquid path of the switching valve in real time, monitoring the pressure of the sample injection liquid path by the switching valve through an external pressure sensor in real time, and indicating that the bubbles appear in the sample injection liquid path if the pressure is lower;
step S2: when the occurrence of bubbles in the liquid path is monitored, the switching valve is switched to an exhaust state, and an exhaust liquid path is formed in the switching valve in the exhaust state;
step S3: the bubbles are discharged out of the switching valve through the exhaust liquid path;
step S4: when the bubbles are detected to be completely discharged out of the switching valve, the switching valve is sequentially switched to a loading state and a sample injection state.
According to another aspect of the present application, embodiments of the present application also provide an analysis apparatus including a switching valve for an analysis apparatus as described above.
Further, referring to fig. 8, when the analysis device is specifically used, after the whole workflow starts, the system is reset, and then the system determines whether the switching valve needs to be exhausted. If the system judges that the switching valve does not need to exhaust, the loading step and the sample injection step are sequentially carried out, and the sample is input into the column tube 5 for analysis. If the system judges that the switching valve needs to exhaust, the switching valve is firstly switched to an exhaust state to completely exhaust bubbles, and then the loading step and the sample injection step are sequentially carried out.
In the above embodiments of the present application, the switching valve does not need an external exhaust valve, and can realize loading, sample injection and exhaust functions by itself, the switching valve can monitor the liquid pressure in real time through an external pressure sensor, if the pressure is low, it indicates that there is a bubble, and after the control system determines that there is a bubble, the switching valve is controlled to an exhaust state to exhaust the bubble, so that the difficulty of exhausting the switching valve is reduced; meanwhile, the automatic valve control system with high efficiency, reliability, stability and simplicity and convenience in operation is provided for the analysis equipment, the problems of complex structure, complex exhaust operation and low analysis efficiency of the analysis equipment are solved, and the working efficiency of the analysis equipment is improved.
The automatic valve control system with high efficiency, reliability, stability and simple operation is provided for the analysis equipment, the problems of complex structure, complex exhaust operation and low analysis efficiency of the analysis equipment are solved, and the working efficiency of the analysis equipment is improved.
Compared with manual valve control operation of an experimenter, the full-automatic valve control program is integrated in the control software of the original analysis equipment, so that the accuracy and reliability of the analysis equipment are obviously improved; and the integrated software is simple and convenient to operate, no extra hardware is needed, and the analysis equipment can work even if not on duty, so that the workload of experiment operators is greatly reduced.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features in the above-described embodiments are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples only represent a few embodiments of the present application, which are described in more detail and are not to be construed as limiting the scope of the claims. It should be noted that it would be apparent to those skilled in the art that various modifications and improvements could be made without departing from the spirit of the present application, which would be within the scope of the present application. Accordingly, the scope of protection of the present application is to be determined by the claims appended hereto.
Claims (4)
1. The switching valve for the analysis equipment is characterized by comprising a stator and a rotor capable of rotating relative to the stator, wherein a plurality of grooves are formed in the end face of the rotor facing the stator, a plurality of through holes are formed in the stator corresponding to the grooves, and the switching valve is switched among a loading state, a sample injection state and an exhaust state according to the rotating position of the rotor;
when the switching valve is in the loading state, at least a loading liquid path is formed between the groove and the through hole;
when the switching valve is in the sample injection state, at least a sample injection liquid path is formed between the groove and the through hole;
when the switching valve is in the exhaust state, at least an exhaust liquid path is formed between the groove and the through hole;
a first circular contour line is arranged on the end face, facing the stator, of the rotor, the first circular contour line is provided with a first circle center, a first identification point, a second identification point, a third identification point, a fourth identification point, a fifth identification point and a sixth identification point which are used for equally dividing the first circular contour line into six parts are sequentially arranged on the first circular contour line, a linear groove, a first arc groove and a second arc groove are arranged on the rotor, two ends of the linear groove correspond to the first circle center and the first identification point of the first circular contour line respectively, two ends of the first arc groove correspond to the second identification point and the third identification point respectively, and two ends of the second arc groove correspond to the fourth identification point and the fifth identification point respectively;
a second circular contour line is arranged on the end face, facing the rotor, of the stator, corresponding to the first circular contour line, the second circular contour line is provided with a second circle center, a first mark point, a second mark point, a third mark point, a fourth mark point, a fifth mark point and a sixth mark point which are used for dividing the second circular contour line into six equal parts are sequentially arranged on the second circular contour line, a first through hole pointing to the first mark point, a second through hole pointing to the second mark point, a third through hole pointing to the third mark point, a fourth through hole pointing to the fourth mark point, a fifth through hole pointing to the fifth mark point, a sixth through hole pointing to the sixth mark point and a seventh through hole pointing to the second circle center are arranged on the stator;
the switching valve is externally connected with a sample injection ring, and two ends of the sample injection ring are respectively connected with the first through hole and the fourth through hole; the switching valve is externally connected with a pump body, and the pump body is connected with the second through hole; the switching valve is externally connected with a column tube, and the column tube is connected with the third through hole; the switching valve is externally connected with a sampling tube, and the sampling tube is connected to the fifth through hole; the switching valve is externally connected with a discharge pipe, and the discharge pipe is connected with the seventh through hole;
when the switching valve is in the loading state, the linear groove is communicated with the first through hole and the seventh through hole, the first arc-shaped groove is communicated with the second through hole and the third through hole, and the second arc-shaped groove is communicated with the fourth through hole and the fifth through hole;
when the switching valve is in the sample injection state, the linear groove is communicated with the sixth through hole and the seventh through hole, the first arc-shaped groove is communicated with the first through hole and the second through hole, and the second arc-shaped groove is communicated with the third through hole and the fourth through hole;
when the switching valve is in the exhaust state, the linear groove is communicated with the second through hole and the seventh through hole, the first arc-shaped groove is communicated with the third through hole and the fourth through hole, and the second arc-shaped groove is communicated with the fifth through hole and the sixth through hole.
2. The switching valve for an analytical device according to claim 1, wherein the second through hole to which the pump body is connected is in a high pressure position, and the seventh through hole to which the discharge pipe is connected is in a low pressure position.
3. A switching valve exhaust method for an analysis apparatus, applied to the switching valve for an analysis apparatus according to any one of claims 1 to 2, characterized by comprising the steps of:
monitoring whether bubbles appear in a liquid path of the switching valve in real time, monitoring the pressure of the sample injection liquid path by the switching valve through an external pressure sensor in real time, and indicating that the bubbles appear in the sample injection liquid path if the pressure is lower;
when the occurrence of bubbles in the liquid path is monitored, the switching valve is switched to an exhaust state, and an exhaust liquid path is formed in the switching valve in the exhaust state;
the bubbles are discharged out of the switching valve through the exhaust liquid path;
when the bubbles are detected to be completely discharged out of the switching valve, the switching valve is sequentially switched to a loading state and a sample injection state.
4. An analysis device comprising a switching valve for an analysis device according to any one of claims 1-2.
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| CN202311282457.1A CN117028619B (en) | 2023-10-07 | 2023-10-07 | Switching valve for analysis device, exhaust method, and analysis device |
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| CN202311282457.1A CN117028619B (en) | 2023-10-07 | 2023-10-07 | Switching valve for analysis device, exhaust method, and analysis device |
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Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101675329A (en) * | 2007-09-28 | 2010-03-17 | 株式会社岛津制作所 | Sample introduction device |
| CN203772701U (en) * | 2014-03-03 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Miniaturized flow cytometry liquid path system |
| CN104458953A (en) * | 2014-12-05 | 2015-03-25 | 北京佰纯润宇生物科技有限公司 | Chromatographic system for realizing forward and reverse flow and bypass functions of chromatographic column based on three-position seven-way valve |
| CN105158357A (en) * | 2015-08-18 | 2015-12-16 | 苏州赛谱仪器有限公司 | Chromatographic device adopting column level valve |
| CN105987975A (en) * | 2015-03-16 | 2016-10-05 | 株式会社岛津制作所 | Autosampler and liquid chromatograph |
| CN109541094A (en) * | 2018-12-11 | 2019-03-29 | 苏州英赛斯智能科技有限公司 | A kind of selector valve and liquid-chromatography apparatus |
| CN209198399U (en) * | 2018-11-09 | 2019-08-02 | 苏州赛谱仪器有限公司 | A kind of sampling valve and column selector valve are combined chromatographic apparatus |
| CN114518426A (en) * | 2022-03-03 | 2022-05-20 | 宁波艾纯生物科技有限公司 | Sample injection valve |
| CN116480811A (en) * | 2023-04-23 | 2023-07-25 | 觅一科技(北京)有限公司 | Rotary valve and sample injection system for sample injection |
-
2023
- 2023-10-07 CN CN202311282457.1A patent/CN117028619B/en active Active
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101675329A (en) * | 2007-09-28 | 2010-03-17 | 株式会社岛津制作所 | Sample introduction device |
| CN203772701U (en) * | 2014-03-03 | 2014-08-13 | 中国科学院苏州生物医学工程技术研究所 | Miniaturized flow cytometry liquid path system |
| CN104458953A (en) * | 2014-12-05 | 2015-03-25 | 北京佰纯润宇生物科技有限公司 | Chromatographic system for realizing forward and reverse flow and bypass functions of chromatographic column based on three-position seven-way valve |
| CN105987975A (en) * | 2015-03-16 | 2016-10-05 | 株式会社岛津制作所 | Autosampler and liquid chromatograph |
| CN105158357A (en) * | 2015-08-18 | 2015-12-16 | 苏州赛谱仪器有限公司 | Chromatographic device adopting column level valve |
| CN209198399U (en) * | 2018-11-09 | 2019-08-02 | 苏州赛谱仪器有限公司 | A kind of sampling valve and column selector valve are combined chromatographic apparatus |
| CN109541094A (en) * | 2018-12-11 | 2019-03-29 | 苏州英赛斯智能科技有限公司 | A kind of selector valve and liquid-chromatography apparatus |
| CN114518426A (en) * | 2022-03-03 | 2022-05-20 | 宁波艾纯生物科技有限公司 | Sample injection valve |
| CN116480811A (en) * | 2023-04-23 | 2023-07-25 | 觅一科技(北京)有限公司 | Rotary valve and sample injection system for sample injection |
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| CN117028619A (en) | 2023-11-10 |
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