CN116999395A - Method for preparing flavored dark plum pill into extract and granule - Google Patents
Method for preparing flavored dark plum pill into extract and granule Download PDFInfo
- Publication number
- CN116999395A CN116999395A CN202310153208.6A CN202310153208A CN116999395A CN 116999395 A CN116999395 A CN 116999395A CN 202310153208 A CN202310153208 A CN 202310153208A CN 116999395 A CN116999395 A CN 116999395A
- Authority
- CN
- China
- Prior art keywords
- extract
- filtrate
- dark plum
- water
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006187 pill Substances 0.000 title claims abstract description 36
- 239000000284 extract Substances 0.000 title claims abstract description 20
- 239000008187 granular material Substances 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title description 7
- 239000000843 powder Substances 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- 239000000706 filtrate Substances 0.000 claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 20
- 241000173529 Aconitum napellus Species 0.000 claims abstract description 16
- 229940023019 aconite Drugs 0.000 claims abstract description 16
- 241000758794 Asarum Species 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims abstract description 11
- 238000004140 cleaning Methods 0.000 claims abstract description 10
- 238000001914 filtration Methods 0.000 claims abstract description 10
- 238000004806 packaging method and process Methods 0.000 claims abstract description 10
- 239000007779 soft material Substances 0.000 claims abstract description 10
- 229910001220 stainless steel Inorganic materials 0.000 claims abstract description 10
- 239000010935 stainless steel Substances 0.000 claims abstract description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims abstract description 9
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 9
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 9
- 239000008103 glucose Substances 0.000 claims abstract description 9
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 9
- 238000000643 oven drying Methods 0.000 claims abstract description 5
- 238000003825 pressing Methods 0.000 claims abstract description 5
- 238000010298 pulverizing process Methods 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims abstract description 5
- 235000013399 edible fruits Nutrition 0.000 claims description 17
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- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 6
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- 210000002784 stomach Anatomy 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
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- 241000234314 Zingiber Species 0.000 description 10
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- 241000037740 Coptis chinensis Species 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 2
- 244000131316 Panax pseudoginseng Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 235000017965 Asarum canadense Nutrition 0.000 description 1
- 235000000385 Costus speciosus Nutrition 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 241000606265 Valeriana jatamansi Species 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 235000014687 Zingiber zerumbet Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
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Classifications
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- A61K9/1605—Excipients; Inactive ingredients
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Abstract
The invention belongs to the technical field of research and development of traditional Chinese medicines. The invention relates to a preparation method for changing flavored dark plum pills into extract and granules. Cleaning radix Aconiti lateralis Preparata and herba asari respectively, oven drying, and pulverizing into powder; cleaning other materials in the formula, oven drying, and pulverizing into powder; putting the aconite powder into a stainless steel container, and decocting the aconite for 2 hours and the asarum for 1 hour; placing other medicinal materials in the formula into a stainless steel container filled with radix Aconiti lateralis Preparata and herba asari solution, mixing, decocting with water for 1 hr, and filtering to obtain filtrate and residue; repeatedly decocting for 1 time, and filtering to obtain filtrate and residue; filter-pressing the residues, and combining the filtrates; concentrating the filtrate under reduced pressure to obtain extract, bottling, and packaging; adding appropriate amount of maltodextrin and glucose into the extract, stirring, and making into soft material; granulating the soft material, oven drying, grading, and packaging. The product has the effects of relieving liver and regulating middle warmer, clearing heat and warming the stomach, nourishing yin and yin, supplementing qi and nourishing blood, invigorating stomach and nourishing spleen, moistening lung and clearing heart fire, and calming the heart and soothing the nerves.
Description
Technical Field
The invention belongs to the technical field of research and development of traditional Chinese medicines. The invention relates to a preparation method for changing flavored dark plum pills into extract and granules. The product has the effects of relieving liver and regulating middle warmer, clearing heat and warming the stomach, nourishing yin and yin, supplementing qi and nourishing blood, invigorating stomach and nourishing spleen, moistening lung and clearing heart fire, and calming the heart and soothing the nerves.
Background
The dark plum pill is prepared from ten medicines of dark plum flesh, coptis chinensis, phellodendron bark, aconite (processed), dried ginger, cassia twig, asarum, pricklyash peel, ginseng and angelica.
The existing preparation of mume fructus pill is watered pill or honeyed pill.
The traditional preparation method of the Chinese medicinal water pill is also called water-spraying pill, which is a small spherical pill prepared by taking cold boiled water, medicinal juice or other liquid as adhesive (wetting) agent. The watered pill is developed on the basis of decoction. The decoction of one part of the medicines and the fine powder of the other part of the medicines in the prescription are prepared into decoction pills by a dripping pill method, then gradually evolve, and all or part of the fine powder of the medicines in the prescription are prepared into pellets by a general method by taking various water-soluble liquids as adhesives. The pill diameter is generally that Between them.
The preparation method is a traditional watered pill preparation method in China, and is also a unique traditional Chinese medicine preparation method in China. The initial process of manual pill making includes: preparing raw material powder, drawing, forming, capping, drying, sieving, coating and polishing, quality inspection and the like. The drawing die is the basis of pill forming, is a key link for preparing water pills, and the shape of the die directly influences the roundness of a finished product, the granularity difference and the number of the die, and the screening times in the process, the specification of the pills and the uniformity of the drug content. At present, the manual pill making has the advantages of high labor intensity, low yield and serious pollution, and is basically replaced by mechanical pill making. The principle of mechanical pill making is the same as that of manual pill making, and the operation method and steps are generally consistent with those of manual pill making except that the mechanical pill making reduces the labor intensity of workers, shortens the production time, reduces the pollution opportunity and the like.
Pulverizing ten medicinal materials of mume fructus, coptidis rhizoma, cortex Phellodendri, radix Aconiti lateralis Preparata, zingiberis rhizoma, ramulus Cinnamomi, herba asari, fructus Zanthoxyli, ginseng radix and radix Angelicae sinensis into fine powder, and mixing. Making into watered pill, drying, and making into watered pill; or 100g of powder is added with 120-130g of refined honey to prepare big honeyed pills.
Has effects of relieving liver and regulating middle energizer, and clearing heat. It is commonly used in traditional Chinese medicine to treat chronic dysentery, and symptoms of jueyin headache, such as abdominal pain, diarrhea, top headache, dysphoria, emesis, etc.
The flavored dark plum pill comprises dark plum flesh, aconite root, asarum, dried ginger, cassia twig, pricklyash peel, dangshen, angelica, coptis, phellodendron bark, dwarf lilyturf tuber, largehead atractylodes rhizome, astragalus root, glossy privet fruit, eclipta alba, shizandra berry, lily bulb, chinese date and liquorice.
The flavored dark plum pill is changed into extract and granule, which is favorable for the full absorption and utilization of the effective components in the medicinal materials by human bodies.
The product has the effects of relieving liver and regulating middle warmer, clearing heat and warming the stomach, nourishing yin and yin, supplementing qi and nourishing blood, invigorating stomach and nourishing spleen, moistening lung and clearing away heart-fire, and calming the heart and soothing the nerves.
Disclosure of Invention
1. A preparation method for changing flavored dark plum pills into extract and granules is characterized by comprising the following steps:
(1) The raw materials and auxiliary materials comprise dark plum, aconite, asarum, dried ginger, cassia twig, pricklyash peel, dangshen, angelica, coptis, phellodendron, dwarf lilyturf tuber, largehead atractylodes rhizome, astragalus root, glossy privet fruit, eclipta alba, shizandra berry, lily, chinese date, liquorice, maltodextrin and glucose;
(2) Cleaning radix Aconiti lateralis Preparata and herba asari in (1), oven drying, and pulverizing into 20-40 mesh powder;
(3) Cleaning dark plum, dried ginger, cassia twig, pricklyash peel, dangshen, chinese angelica, coptis, amur corktree bark, dwarf lilyturf tuber, largehead atractylodes rhizome, membranous milkvetch root, glossy privet fruit, eclipta alba, chinese magnoliavine fruit, lily, chinese date and liquoric root in the step (1), drying and crushing into powder of 20-40 meshes;
(4) Placing the aconite 20-40 mesh powder in the step (2) into a stainless steel container, adding water to decoct for 1h-1.2h, then placing the asarum 20-40 mesh powder, and continuing to decoct for 1h-1.2h; the water adding amount is 5-6 times of the total weight of the medicinal materials, and the temperature is 100 ℃.
(5) Placing 20-40 mesh powder of mume fructus, zingiberis rhizoma, ramulus Cinnamomi, fructus Zanthoxyli, radix Codonopsis, radix Angelicae sinensis, coptidis rhizoma, cortex Phellodendri, radix Ophiopogonis, atractylodis rhizoma, radix astragali, fructus Ligustri Lucidi, ecliptae herba, fructus Schisandrae chinensis, bulbus Lilii, fructus Jujubae, glycyrrhrizae radix in (4) stainless steel container filled with radix Aconiti lateralis Preparata and herba asari solution, decocting with water for 1-1.2 hr, adding water 5-6 times of the total weight of the materials, filtering at 95-98deg.C to obtain filtrate and residue;
(6) Decocting the residue in step (5) with water for 1-1.2 hr, wherein the water content is 4-5 times of the total weight of the medicinal materials, the temperature is 80-95deg.C, and filtering to obtain filtrate and residue;
(7) Filter-pressing residues in the steps (5) and (6), and combining filtrate with filtrate in the steps (5) and (6);
(8) Concentrating the filtrate in step (7) under reduced pressure to obtain an extract, bottling and packaging;
(9) Adding appropriate amount of maltodextrin and glucose into the extract in step (8), stirring uniformly, and preparing soft material;
(10) Granulating the soft material in the step (9), drying, finishing and packaging.
Detailed Description
The invention relates to a method for preparing flavored dark plum pills into extracts and granules, which comprises the following examples, which are further illustrative of the invention but are not in any way limiting.
Example 1:
1. a preparation method for changing flavored dark plum pills into extract and granules is characterized by comprising the following steps:
(1) The raw materials and auxiliary materials comprise dark plum, aconite, asarum, dried ginger, cassia twig, pricklyash peel, dangshen, angelica, coptis, phellodendron, dwarf lilyturf tuber, largehead atractylodes rhizome, astragalus root, glossy privet fruit, eclipta alba, shizandra berry, lily, chinese date, liquorice, maltodextrin and glucose;
(2) Cleaning, drying and crushing the aconite and the asarum in the step (1) into 20-mesh powder respectively;
(3) Cleaning dark plum, dried ginger, cassia twig, pricklyash peel, dangshen, chinese angelica, coptis, amur corktree bark, dwarf lilyturf tuber, largehead atractylodes rhizome, membranous milkvetch root, glossy privet fruit, eclipta alba, chinese magnoliavine fruit, lily, chinese date and liquoric root in the step (1), drying and crushing into 20-mesh powder;
(4) Placing the aconite 20 mesh powder in the step (2) into a stainless steel container, adding water for decoction for 1h, then placing the asarum 20 mesh powder, and continuously decocting for 1h; the water adding amount is 5 times of the total weight of the medicinal materials, and the temperature is 100 ℃;
(5) Placing 20 mesh powder of dark plum, dried ginger, cassia twig, pricklyash peel, dangshen, angelica, coptis chinensis, amur corktree bark, dwarf lilyturf tuber, largehead atractylodes rhizome, membranous milkvetch root, glossy privet fruit, eclipta alba, chinese magnoliavine fruit, lily bulb, chinese date and liquoric root in the step (3) into a stainless steel container filled with a solution of aconite and manchurian wildginger, adding water, continuously decocting for 1h, wherein the water adding amount is 5 times of the total weight of medicinal materials, the temperature is 95 ℃, and filtering to obtain filtrate and residues;
(6) Decocting the residue in step (5) in water for 1 hr, wherein the water content is 4 times of the total weight of the medicinal materials, the temperature is 80deg.C, and filtering to obtain filtrate and residue;
(7) Filter-pressing residues in the steps (5) and (6), and combining filtrate with filtrate in the steps (5) and (6);
(8) Concentrating the filtrate in step (7) under reduced pressure to obtain an extract, bottling and packaging;
(9) Adding appropriate amount of maltodextrin and glucose into the extract in step (8), stirring uniformly, and preparing soft material;
(10) Granulating the soft material in the step (9), drying, finishing and packaging.
Example 2:
1. a preparation method for changing flavored dark plum pills into extract and granules is characterized by comprising the following steps:
(1) The raw materials and auxiliary materials comprise dark plum, aconite, asarum, dried ginger, cassia twig, pricklyash peel, dangshen, angelica, coptis, phellodendron, dwarf lilyturf tuber, largehead atractylodes rhizome, astragalus root, glossy privet fruit, eclipta alba, shizandra berry, lily, chinese date, liquorice, maltodextrin and glucose;
(2) Cleaning, drying and crushing the aconite and the asarum in the step (1) into 40-mesh powder respectively;
(3) Cleaning dark plum, dried ginger, cassia twig, pricklyash peel, dangshen, chinese angelica, coptis, amur corktree bark, dwarf lilyturf tuber, largehead atractylodes rhizome, membranous milkvetch root, glossy privet fruit, eclipta alba, chinese magnoliavine fruit, lily, chinese date and liquoric root in the step (1), drying and crushing into 40 mesh powder;
(4) Placing the aconite 20-40 mesh powder in the step (2) into a stainless steel container, adding water to decoct for 1.2h, then placing the asarum 40 mesh powder, and continuing to decoct for 1.2h; the water adding amount is 6 times of the total weight of the medicinal materials, and the temperature is 100 ℃;
(5) Placing 20-40 mesh powder of dark plum, dried ginger, cassia twig, pricklyash peel, dangshen, angelica, coptis chinensis, phellodendron bark, dwarf lilyturf tuber, largehead atractylodes rhizome, astragalus root, glossy privet fruit, eclipta alba, chinese magnoliavine fruit, lily bulb, chinese date and liquorice in the step (3) into a stainless steel container filled with a solution of aconite and asarum, adding water, continuously decocting for 1.2 hours, wherein the water adding amount is 6 times of the total weight of the medicinal materials, the temperature is 98 ℃, and filtering to obtain filtrate and residues;
(6) Decocting the residue in step (5) in water for 1.2 hr, wherein the water content is 5 times of the total weight of the medicinal materials, the temperature is 95deg.C, and filtering to obtain filtrate and residue;
(7) Filter-pressing residues in the steps (5) and (6), and combining filtrate with filtrate in the steps (5) and (6);
(8) Concentrating the filtrate in step (7) under reduced pressure to obtain an extract, bottling and packaging;
(9) Adding appropriate amount of maltodextrin and glucose into the extract in step (8), stirring uniformly, and preparing soft material;
(10) Granulating the soft material in the step (9), drying, finishing and packaging.
Claims (1)
1. A preparation method for changing flavored dark plum pills into extract and granules is characterized by comprising the following steps:
(1) The raw materials and auxiliary materials comprise dark plum, aconite, asarum, dried ginger, cassia twig, pricklyash peel, dangshen, angelica, coptis, phellodendron, dwarf lilyturf tuber, largehead atractylodes rhizome, astragalus root, glossy privet fruit, eclipta alba, shizandra berry, lily, chinese date, liquorice, maltodextrin and glucose;
(2) Cleaning radix Aconiti lateralis Preparata and herba asari in (1), oven drying, and pulverizing into 20-40 mesh powder;
(3) Cleaning dark plum, dried ginger, cassia twig, pricklyash peel, dangshen, chinese angelica, coptis, amur corktree bark, dwarf lilyturf tuber, largehead atractylodes rhizome, membranous milkvetch root, glossy privet fruit, eclipta alba, chinese magnoliavine fruit, lily, chinese date and liquoric root in the step (1), drying and crushing into powder of 20-40 meshes;
(4) Placing the aconite 20-40 mesh powder in the step (2) into a stainless steel container, adding water to decoct for 1h-1.2h, then placing the asarum 20-40 mesh powder, and continuing to decoct for 1h-1.2h; the water adding amount is 5-6 times of the total weight of the medicinal materials, and the temperature is 100 ℃;
(5) Placing 20-40 mesh powder of mume fructus, zingiberis rhizoma, ramulus Cinnamomi, fructus Zanthoxyli, radix Codonopsis, radix Angelicae sinensis, coptidis rhizoma, cortex Phellodendri, radix Ophiopogonis, atractylodis rhizoma, radix astragali, fructus Ligustri Lucidi, ecliptae herba, fructus Schisandrae chinensis, bulbus Lilii, fructus Jujubae, glycyrrhrizae radix in (4) stainless steel container filled with radix Aconiti lateralis Preparata and herba asari solution, decocting with water for 1-1.2 hr, adding water 5-6 times of the total weight of the materials, filtering at 95-98deg.C to obtain filtrate and residue;
(6) Decocting the residue in step (5) with water for 1-1.2 hr, wherein the water content is 4-5 times of the total weight of the medicinal materials, the temperature is 80-95deg.C, and filtering to obtain filtrate and residue;
(7) Filter-pressing residues in the steps (5) and (6), and combining filtrate with filtrate in the steps (5) and (6);
(8) Concentrating the filtrate in step (7) under reduced pressure to obtain an extract, bottling and packaging;
(9) Adding appropriate amount of maltodextrin and glucose into the extract in step (8), stirring uniformly, and preparing soft material;
(10) Granulating the soft material in the step (9), drying, finishing and packaging.
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