CN116942575B - Mild anti-dandruff composition, and preparation method and application thereof - Google Patents

Mild anti-dandruff composition, and preparation method and application thereof Download PDF

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CN116942575B
CN116942575B CN202310735157.8A CN202310735157A CN116942575B CN 116942575 B CN116942575 B CN 116942575B CN 202310735157 A CN202310735157 A CN 202310735157A CN 116942575 B CN116942575 B CN 116942575B
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dandruff
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CN116942575A (en
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张飞
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Guangdong Juxintang Pharmaceutical Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention relates to the technical field of washing and caring products, and particularly discloses a mild anti-dandruff composition, a preparation method and application thereof. A mild antidandruff composition is prepared from fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract. The invention has the advantage of prolonged duration of the anti-dandruff effect.

Description

Mild anti-dandruff composition, and preparation method and application thereof
Technical Field
The invention relates to the field of washing and caring products, in particular to a mild anti-dandruff composition, a preparation method and application thereof.
Background
The dandruff is a normal product of metabolism of a human body, and trace dandruff does not bring about obvious influence, but excessive dandruff can greatly reduce the attractiveness of the hair, seriously influence the attractiveness and increase the dandruff, and most of the dandruff is caused by excessive propagation of malassezia furfur in the scalp, so that the normal metabolism of the scalp is damaged, the horny layer is abnormally shed, and the dandruff is increased, so that the hair is quite unclean, and the hair is quite unsightly.
With the pursuit of beauty by consumers, the beauty of hair is increasingly emphasized, and consumers with more dandruff usually use anti-dandruff washing products to remove the dandruff to expect the hair to be more beautiful, but the existing anti-dandruff products can remove the dandruff after washing the hair, but inhibit the durability of the dandruff to be poor, so that the consumers with more dandruff need frequent washing of the hair to keep the hair clean and beautiful, which is very inconvenient, and therefore, there is room for improvement.
Disclosure of Invention
In order to prolong the durability of inhibiting dandruff, the application provides a mild anti-dandruff composition, and a preparation method and application thereof.
In a first aspect, the present application provides a mild anti-dandruff composition, which adopts the following technical scheme:
a mild anti-dandruff composition is prepared from fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract.
By adopting the technical scheme, the mild anti-dandruff composition prepared by compounding the haw extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract is added into the washing and caring product, can effectively kill the malassezia furfur, can be well absorbed by skin cells after being compounded, enables the scalp to have the effect of permanently inhibiting malassezia furfur, enables the scalp not to be easy to grow the malassezia furfur in a large amount, enables the scalp to gradually recover health, enables the metabolism of the scalp to recover to be normal, radically treats scalp diseases, reduces the phenomenon of increasing dandruff caused by scalp cell metabolism disorder, achieves the effect of permanently inhibiting the dandruff, enables consumers with lower shampoo frequency to permanently keep hair clean, and enables the hair to permanently keep attractive.
Preferably, the mass ratio of the haw extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract is 5-7:7-9:4-6:8-10:3-5.
By adopting the technical scheme, the anti-dandruff composition has better and more durable effect of inhibiting dandruff by specifically selecting the mass ratio of the hawthorn extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract, and the prepared washing and caring product can better and permanently inhibit dandruff and better keep hair beautiful.
Preferably, the preparation method of the haw extract comprises the following steps:
cutting fructus crataegi, freezing to below 0deg.C to obtain frozen fructus crataegi, adding into water, heating to boil, condensing and refluxing, extracting for 6-8 hr, filtering, collecting filtrate, concentrating, and drying to obtain fructus crataegi extract.
By adopting the technical scheme, the frozen extract is utilized to puncture the cells of the hawthorn fruits, so that the effective components are better released, the extraction effect is better, the active components are more abundant, the condition that the efficacy of a compound system is affected due to poor extraction effect of part of the active components is reduced, and the effect of better lasting anti-dandruff effect can be achieved after the compound composition is compounded with other compositions.
Preferably, the preparation method of the kiwi fruit extract comprises the following steps:
crushing fructus Actinidiae chinensis into fructus Actinidiae chinensis pulp by wall breaking machine, adding fructus Actinidiae chinensis pulp into water, inoculating yeast, fermenting for 2-3d, heating to boiling, condensing and refluxing, extracting for 1-2h, filtering, collecting filtrate, concentrating the filtrate, and drying to obtain fructus Actinidiae chinensis extract.
By adopting the technical scheme, fermentation is carried out after the fruit pulp is formed through wall breaking, then extraction is carried out, the effect of compounding the extracted active ingredient with other compositions is better, special metabolites can be produced through fermentation, the structure of the active ingredient is changed, the active ingredient is easier to be absorbed by skin, the effect of durably inhibiting malassezia furfur is better, and the effect of durably inhibiting dandruff is better realized.
Preferably, the preparation method of the bunge cherry seed extract comprises the following steps:
cutting semen Pruni, adding into water, inoculating Aspergillus niger and Penicillium chrysogenum, soaking and extracting for 6-7d, heating to boil, condensing and refluxing, extracting for 2-3h, filtering, collecting filtrate, concentrating, and drying to obtain semen Pruni extract.
By adopting the technical scheme, the semen pruni is extracted by matching the aspergillus niger and the penicillium chrysogenum, so that the active ingredients in the semen pruni are better extracted, the types of the active ingredients are more abundant, the irritation can be reduced, and the effect of inhibiting dandruff is better after the semen pruni is matched with other compositions.
Preferably, the Yang Zaoshu skin extract is prepared by the following steps:
cutting Yang Zaoshu skin, adding into water, inoculating Bacillus subtilis and Fusarium graminearum, soaking and extracting for 6-7d, heating to boil, condensing and refluxing, extracting for 2-3 hr, filtering, collecting filtrate, concentrating the filtrate, and drying to obtain Yang Zaoshu skin extract.
Through adopting above-mentioned technical scheme, through bacillus subtilis, cereal fusarium cooperation extraction Yang Zao bark for the extraction effect is better, and the active ingredient content of extracting is higher, and the kind is richer, and the pungency is lower, cooperates with other components better, thereby makes the effect of lasting restraint dandruff better.
Preferably, the preparation method of the willow herb extract comprises the following steps:
adding herba Salicis Babylonicae into 60-70% ethanol solution, heating to boiling, condensing and refluxing, extracting for 6-8 hr, recovering ethanol, filtering, collecting filtrate, concentrating the filtrate, and drying to obtain herba Salicis Babylonicae extract.
By adopting the technical scheme, the active ingredients in the willow herb are more fully extracted by adopting high-concentration ethanol for extraction, the types of the active ingredients are more abundant, the effect of matching with other components is better, and the effect of more durable dandruff inhibition is realized.
In a second aspect, the present application provides a method for preparing a mild anti-dandruff composition, which adopts the following technical scheme:
the preparation method of the mild anti-dandruff composition is characterized by comprising the following steps of: the preparation method of the mild anti-dandruff composition comprises the following steps: adding fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract into water, homogenizing for 5-8min, stirring for 30-40min, concentrating, and drying to obtain mild anti-dandruff composition.
By adopting the technical scheme, the extracts are dissolved in water and then homogenized and stirred, so that the active ingredients are uniformly dispersed, the proportion of each active ingredient can be better kept stable, better synergistic effect is generated, and the effect of durably inhibiting dandruff is better.
In a third aspect, the present application provides an application of a mild anti-dandruff composition, which adopts the following technical scheme:
use of a mild anti-dandruff composition as described above, added to a laundry product, for the preparation of a laundry product having a mild anti-dandruff effect.
By adopting the technical scheme, the washing and caring product has good anti-dandruff effect, and the anti-dandruff effect is very durable and is deeply favored by consumers.
Preferably, the mild anti-dandruff composition is added to the cleaning product in an amount of 2.7-3.7%.
By adopting the technical scheme, the anti-dandruff composition can play a good role in permanently inhibiting dandruff by specifically selecting the adding amount of the anti-dandruff composition, and can also control the cost well, so that the prepared washing and caring product has higher economic value.
In summary, the present application has the following beneficial effects:
1. the mild anti-dandruff composition compounded by the haw extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract can effectively kill malassezia furfur after being added into the washing and caring product, and the haw extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract can be well absorbed by skin cells after being compounded, so that the scalp has the effect of permanently inhibiting malassezia furfur, the scalp is not easy to grow a large amount of malassezia furfur, the scalp can gradually recover health, scalp metabolism is restored to be normal, scalp diseases are radically cured, the phenomenon of increasing dandruff caused by scalp cell metabolic disorder is reduced, the effect of permanently inhibiting the dandruff is realized, consumers with low shampoo frequency can permanently keep hair clean, and the hair can permanently keep attractive.
2. The mass ratio of the hawthorn extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract is preferably selected in the application, so that the anti-dandruff composition has better and longer-lasting anti-dandruff effect, and the prepared washing and caring product can better and longer-lasting inhibit dandruff and better maintain the attractive appearance of hair.
3. In the application, the preparation method of the hawthorn extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract is preferably selected in particular, so that the mutual matching effect of active ingredients in the components is better, and the better effect of durably inhibiting dandruff is achieved.
Detailed Description
The present application is described in further detail below with reference to examples.
Example 1
A mild anti-dandruff composition, which is prepared from the following components:
fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract.
Wherein the haw extract is self-made, and the preparation method of the haw extract is as follows:
step 1), cutting haw into fruit granules, and freezing the fruit granules to-10 ℃ in a refrigerator to form frozen haw fruit granules.
Step 2), weighing 10kg of frozen hawthorn fruit pieces, putting into a reaction kettle, injecting 50kg of water, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 6 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the hawthorn extract.
Wherein, the kiwi fruit extract is self-made, and the preparation method of the kiwi fruit extract is as follows:
step 1), crushing kiwi fruits into kiwi fruit pulp through a wall breaking machine.
Step 2), weighing 10kg of kiwi fruit pulp and 30kg of water, putting into a container, stirring at a rotating speed of 120r/min for 5min, inoculating 4g of saccharomycetes, fermenting for 2d, heating to boiling, keeping boiling for extraction, condensing and refluxing, extracting for 1h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the kiwi fruit extract.
Wherein the bunge cherry seed extract is self-made, and the preparation method of the bunge cherry seed extract is as follows:
step 1), cutting the bunge cherry seeds into particles to form bunge cherry seed particles.
Step 2), weighing 10kg of bunge cherry seed particles and 40kg of water, putting into a container, soaking for 2 hours, inoculating 2g of aspergillus niger and 3g of penicillium chrysogenum, soaking and extracting for 6 days at a constant temperature of 36 ℃, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 2 hours, filtering by a 200 filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the bunge cherry seed extract.
Wherein the Yang Zaoshu skin extract is prepared by home-made, and the Yang Zaoshu skin extract is prepared by the following steps:
step 1), the Yang Zaoshu skin is chopped into particles to form Yang Zaoshu skin particles.
Step 2), weighing 10kg Yang Zaoshu skin particles and 40kg water, putting into a container, soaking for 4 hours, inoculating 2g of bacillus subtilis and 3g of fusarium graminearum, soaking and extracting for 6 days, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 2 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the Yang Zaoshu skin extract.
The willow herb extract is self-made, and the preparation method of the willow herb extract is as follows:
step 1), weighing 10kg of willow herb, adding 30kg of 60% ethanol solution, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 6 hours, keeping the temperature at 81+/-0.5 ℃, distilling out ethanol to recover ethanol, and filtering by a 200-mesh filter screen after no ethanol is distilled out, thereby obtaining filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the willow extract.
The mild antidandruff composition is prepared as follows:
step 1), weighing 500g of haw extract, 700g of kiwi fruit extract, 400g of bunge cherry seed extract, 800g of Yang Zaoshu skin extract, 300g of willow herb extract and 5000g of water, putting into a stirring kettle, homogenizing for 5-8min at 2500r/min, stopping homogenizing at 120r/min, and stirring for 30-40min to obtain a compound extract.
And 2) concentrating the composite extracting solution by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 60 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the mild anti-dandruff composition.
Wherein, the saccharomycete is purchased from Whan Ke Mike biological medicine technology Co., ltd, specification: 200 billion/g of Saccharomyces boulardii.
Wherein Aspergillus niger is purchased from Hubei Xingjun science and technology Co., ltd, and has the specification of 50 hundred million/g.
Wherein, penicillium chrysogenum is purchased in Shanghai preservation biotechnology center, strain number: SHBCC D24885.
Wherein, the bacillus subtilis is purchased from Jinan Qianjin chemical industry Co., ltd, and the specification is 1000 hundred million/g.
Wherein Fusarium graminearum is purchased from Beijing Bai Ou Bo Wei biotechnology Co., ltd., strain number: ATCC 44344.
Example 2
A mild anti-dandruff composition, which is prepared from the following components:
fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract.
Wherein the haw extract is self-made, and the preparation method of the haw extract is as follows:
step 1), cutting haw into fruit granules, and freezing the fruit granules to-10 ℃ in a refrigerator to form frozen haw fruit granules.
Step 2), weighing 10kg of frozen hawthorn fruit pieces, putting into a reaction kettle, injecting 50kg of water, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 7h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the hawthorn extract.
Wherein, the kiwi fruit extract is self-made, and the preparation method of the kiwi fruit extract is as follows:
step 1), crushing kiwi fruits into kiwi fruit pulp through a wall breaking machine.
Step 2), weighing 10kg of kiwi fruit pulp and 30kg of water, putting into a container, stirring at a rotating speed of 120r/min for 5min, inoculating 4g of saccharomycetes, fermenting for 2.5d, heating to boiling, keeping boiling for extraction, condensing and refluxing, extracting for 1.5h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the kiwi fruit extract.
Wherein the bunge cherry seed extract is self-made, and the preparation method of the bunge cherry seed extract is as follows:
step 1), cutting the bunge cherry seeds into particles to form bunge cherry seed particles.
Step 2), weighing 10kg of bunge cherry seed particles and 40kg of water, putting into a container, soaking for 2 hours, inoculating 2g of aspergillus niger and 3g of penicillium chrysogenum, soaking and extracting for 6.5 days at a constant temperature of 36 ℃, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 2.5 hours, filtering by a 200 filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the bunge cherry seed extract.
Wherein the Yang Zaoshu skin extract is prepared by home-made, and the Yang Zaoshu skin extract is prepared by the following steps:
step 1), the Yang Zaoshu skin is chopped into particles to form Yang Zaoshu skin particles.
Step 2), weighing 10kg Yang Zaoshu skin particles and 40kg water, putting into a container, soaking for 4 hours, inoculating 2g of bacillus subtilis and 3g of fusarium graminearum, soaking and extracting for 6.5 days, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 2.5 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the Yang Zaoshu skin extract.
The willow herb extract is self-made, and the preparation method of the willow herb extract is as follows:
step 1), weighing 10kg of willow herb, adding 30kg of ethanol solution with the concentration of 65%, heating to boiling, keeping boiling extraction, condensing reflux, extracting for 7h, keeping the temperature at 81+/-0.5 ℃, distilling out ethanol to recover ethanol, and filtering by a 200-mesh filter screen after no ethanol is distilled out, thereby obtaining filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the willow extract.
The mild antidandruff composition is prepared as follows:
step 1), weighing 600g of haw extract, 800g of kiwi fruit extract, 500g of bunge cherry seed extract, 900g of Yang Zaoshu skin extract, 400g of willow herb extract and 6000g of water, putting into a stirring kettle, homogenizing for 5-8min at 2500r/min, stopping homogenizing at 120r/min, and stirring for 30-40min to obtain a compound extract.
And 2) concentrating the composite extracting solution by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 60 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the mild anti-dandruff composition.
Wherein, the saccharomycete is purchased from Whan Ke Mike biological medicine technology Co., ltd, specification: 200 billion/g of Saccharomyces boulardii.
Wherein Aspergillus niger is purchased from Hubei Xingjun science and technology Co., ltd, and has the specification of 50 hundred million/g.
Wherein, penicillium chrysogenum is purchased in Shanghai preservation biotechnology center, strain number: SHBCC D24885.
Wherein, the bacillus subtilis is purchased from Jinan Qianjin chemical industry Co., ltd, and the specification is 1000 hundred million/g.
Wherein Fusarium graminearum is purchased from Beijing Bai Ou Bo Wei biotechnology Co., ltd., strain number: ATCC 44344.
Example 3
A mild anti-dandruff composition, which is prepared from the following components:
fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract.
Wherein the haw extract is self-made, and the preparation method of the haw extract is as follows:
step 1), cutting haw into fruit granules, and freezing the fruit granules to-10 ℃ in a refrigerator to form frozen haw fruit granules.
Step 2), weighing 10kg of frozen hawthorn fruit pieces, putting into a reaction kettle, injecting 50kg of water, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 8 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the hawthorn extract.
Wherein, the kiwi fruit extract is self-made, and the preparation method of the kiwi fruit extract is as follows:
step 1), crushing kiwi fruits into kiwi fruit pulp through a wall breaking machine.
Step 2), weighing 10kg of kiwi fruit pulp and 30kg of water, putting into a container, stirring at a rotating speed of 120r/min for 5min, inoculating 4g of saccharomycetes, fermenting for 3d, heating to boiling, keeping boiling for extraction, condensing and refluxing, extracting for 2h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the kiwi fruit extract.
Wherein the bunge cherry seed extract is self-made, and the preparation method of the bunge cherry seed extract is as follows:
step 1), cutting the bunge cherry seeds into particles to form bunge cherry seed particles.
Step 2), weighing 10kg of bunge cherry seed particles and 40kg of water, putting into a container, soaking for 2 hours, inoculating 2g of aspergillus niger and 3g of penicillium chrysogenum, soaking and extracting for 7 days at a constant temperature of 36 ℃, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 3 hours, filtering by a 200 filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the bunge cherry seed extract.
Wherein the Yang Zaoshu skin extract is prepared by home-made, and the Yang Zaoshu skin extract is prepared by the following steps:
step 1), the Yang Zaoshu skin is chopped into particles to form Yang Zaoshu skin particles.
Step 2), weighing 10kg Yang Zaoshu skin particles and 40kg water, putting into a container, soaking for 4 hours, inoculating 2g of bacillus subtilis and 3g of fusarium graminearum, soaking and extracting for 7 days, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 3 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the Yang Zaoshu skin extract.
The willow herb extract is self-made, and the preparation method of the willow herb extract is as follows:
step 1), weighing 10kg of willow herb, adding 30kg of 70% ethanol solution, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 8 hours, keeping the temperature at 81+/-0.5 ℃, distilling out ethanol to recover ethanol, and filtering by a 200-mesh filter screen after no ethanol is distilled out, thereby obtaining filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the willow extract.
The mild antidandruff composition is prepared as follows:
step 1), weighing 700g of haw extract, 900g of kiwi fruit extract, 600g of bunge cherry seed extract, 1000g of Yang Zaoshu skin extract, 500g of willow herb extract and 7000g of water, putting into a stirring kettle, homogenizing for 5-8min at 2500r/min, stopping homogenizing at 120r/min, and stirring for 30-40min to obtain a compound extract.
And 2) concentrating the composite extracting solution by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 60 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the mild anti-dandruff composition.
Wherein, the saccharomycete is purchased from Whan Ke Mike biological medicine technology Co., ltd, specification: 200 billion/g of Saccharomyces boulardii.
Wherein Aspergillus niger is purchased from Hubei Xingjun science and technology Co., ltd, and has the specification of 50 hundred million/g.
Wherein, penicillium chrysogenum is purchased in Shanghai preservation biotechnology center, strain number: SHBCC D24885.
Wherein, the bacillus subtilis is purchased from Jinan Qianjin chemical industry Co., ltd, and the specification is 1000 hundred million/g.
Wherein Fusarium graminearum is purchased from Beijing Bai Ou Bo Wei biotechnology Co., ltd., strain number: ATCC 44344.
Comparative example 1
A mild antidandruff composition which differs from example 2 only in that:
the centella asiatica extract is used for replacing the hawthorn extract in an equivalent way.
Wherein the centella extract is self-made, and the preparation method of the centella extract is as follows:
step 1), cutting centella asiatica into particles, and freezing the particles in a refrigerator to the temperature of minus 10 ℃ to form frozen centella asiatica.
Step 2), weighing 10kg of frozen centella asiatica, putting into a reaction kettle, injecting 50kg of water, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 7h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the centella asiatica extract.
Comparative example 2
A mild antidandruff composition which differs from example 2 only in that:
the purslane extract is adopted to replace the kiwi fruit extract in an equivalent way.
The purslane extract is self-made, and the preparation method of the purslane extract is as follows:
step 1), crushing purslane into purslane pulp through a wall breaking machine.
Step 2), weighing 10kg of purslane pulp and 30kg of water, putting into a container, stirring at a rotating speed of 120r/min for 5min, inoculating 4g of microzyme, fermenting for 2.5d, heating to boiling, keeping boiling for extraction, condensing and refluxing, extracting for 1.5h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the purslane extract.
Wherein, the saccharomycete is purchased from Whan Ke Mike biological medicine technology Co., ltd, specification: 200 billion/g of Saccharomyces boulardii.
Comparative example 3
A mild antidandruff composition which differs from example 2 only in that:
the cassia twig extract is used for replacing the bunge cherry seed extract in an equivalent way.
Wherein the cassia twig extract is self-made, and the preparation method of the cassia twig extract comprises the following steps:
step 1), cutting cassia twig into particles to form cassia twig particles.
Step 2), weighing 10kg of cassia twig particles and 40kg of water, putting into a container, soaking for 2 hours, inoculating 2g of aspergillus niger and 3g of penicillium chrysogenum, soaking and extracting for 6.5 days at a constant temperature of 36 ℃, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 2.5 hours, filtering by a 200 filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the cassia twig extract.
Wherein Aspergillus niger is purchased from Hubei Xingjun science and technology Co., ltd, and has the specification of 50 hundred million/g.
Wherein, penicillium chrysogenum is purchased in Shanghai preservation biotechnology center, strain number: SHBCC D24885.
Comparative example 4
A mild antidandruff composition which differs from example 2 only in that:
the extract of the Yang Zaoshu skin is replaced by the extract of the scutellaria baicalensis in equal quantity.
Wherein the radix Scutellariae extract is prepared by the following steps:
step 1), cutting the baikal skullcap root into particles to form the baikal skullcap root particles.
Step 2), weighing 10kg of baical skullcap root particles and 40kg of water, putting into a container, soaking for 4 hours, inoculating 2g of bacillus subtilis and 3g of fusarium graminearum, soaking and extracting for 6.5 days, heating to boiling, keeping boiling and extracting, condensing and refluxing, extracting for 2.5 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
And 3) concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the baical skullcap root extract.
Wherein, the bacillus subtilis is purchased from Jinan Qianjin chemical industry Co., ltd, and the specification is 1000 hundred million/g.
Wherein Fusarium graminearum is purchased from Beijing Bai Ou Bo Wei biotechnology Co., ltd., strain number: ATCC 44344.
Comparative example 5
A mild antidandruff composition which differs from example 2 only in that:
the dandelion extract is used for replacing the willow herb extract in an equivalent way.
Wherein the dandelion extract is self-made, and the preparation method of the dandelion extract is as follows:
step 1), weighing 10kg of dandelion, putting into 30kg of 65% ethanol solution, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 7h, keeping the temperature at 81+/-0.5 ℃, distilling out ethanol to recover ethanol, and filtering by a 200-mesh filter screen after no ethanol is distilled out, thereby obtaining filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the dandelion extract.
Comparative example 6
A mild antidandruff composition which differs from example 2 only in that:
the centella asiatica extract is used for replacing the hawthorn extract in an equivalent way.
The purslane extract is adopted to replace the kiwi fruit extract in an equivalent way.
The cassia twig extract is used for replacing the bunge cherry seed extract in an equivalent way.
The extract of the Yang Zaoshu skin is replaced by the extract of the scutellaria baicalensis in equal quantity.
The dandelion extract is used for replacing the willow herb extract in an equivalent way.
Wherein the centella asiatica extract is self-made, and the centella asiatica extract is prepared by the centella asiatica preparation method of comparative example 1.
Wherein, the purslane extract is self-made, and the preparation method of the purslane extract adopts the preparation method of purslane of comparative example 2.
Wherein the cassia twig extract is self-made, and the preparation method of the cassia twig extract adopts the preparation method of the cassia twig of comparative example 3.
Wherein the radix Scutellariae extract is prepared by self-control, and the preparation method of the radix Scutellariae extract adopts the preparation method of radix Scutellariae of comparative example 4.
Wherein the dandelion extract is self-made, and the dandelion extract is prepared by the dandelion preparation method of comparative example 5.
Comparative example 7
A mild antidandruff composition which differs from example 2 only in that:
the preparation method of the haw extract comprises the following steps:
step 1), weighing 10kg of haw fruits, chopping the haw fruits into grains, injecting 50kg of water, heating to boiling, keeping boiling for extraction, condensing and refluxing, extracting for 7 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the hawthorn extract.
The preparation method of the kiwi fruit extract comprises the following steps:
step 1), weighing 10kg of kiwi fruits, chopping fruit granules, injecting 50kg of water, heating to boiling, keeping boiling for extraction, condensing and refluxing, extracting for 7 hours, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the kiwi fruit extract.
The preparation method of the bunge cherry seed extract comprises the following steps:
step 1), weighing 10kg of bunge cherry seeds, cutting into particles, injecting 50kg of water, heating to boiling, keeping boiling for extraction, condensing and refluxing, extracting for 7h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the bunge cherry seed extract.
Yang Zaoshu skin extract is prepared by the following steps:
step 1), weighing 10kg Yang Zao bark, cutting into particles, injecting 50kg of water, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 7h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder on the paste for drying to obtain the Yang Zaoshu skin extract.
The preparation method of the willow herb extract comprises the following steps:
step 1), weighing 10kg of willow herb, cutting into particles, injecting 50kg of water, heating to boil, keeping boiling for extraction, condensing and refluxing, extracting for 7h, cooling to below 80 ℃, filtering by a 200-mesh filter screen, and taking filtrate.
Step 2), concentrating the filtrate by rotary steaming, wherein the rotary steaming force is 0.01PMa, the rotary steaming temperature is 58 ℃, concentrating to obtain a paste, and spraying powder and drying the paste to obtain the willow extract.
Application example 1
A mild anti-dandruff shampoo is prepared from the following components:
water, sodium laureth sulfate, disodium EDTA, and mild antidandruff compositions.
The preparation method of the mild anti-dandruff shampoo comprises the following steps:
83.16kg of water, 12kg of sodium laureth sulfate and 2kg of sodium laureth sulfate are weighed, put into an emulsifying pot, heated to 85 ℃, stirred for 30min at the rotating speed of 60r/min, cooled to 45 ℃, added with 0.04kg of EDTA disodium and 2.8kg of mild anti-dandruff composition, homogenized for 2min at 2500r/min at the rotating speed of 60r/, stirred for 5min, and the mild anti-dandruff shampoo is obtained.
Wherein the water is deionized water.
Wherein, laureth sulfate sodium comes from the market, CAS number: 9004-82-4.
Wherein, lauryl sodium sulfate is commercially available and has CAS number: 151-21-3.
Among them, disodium EDTA is commercially available and CAS number: 139-33-3.
Wherein the mild anti-dandruff composition is the mild anti-dandruff composition of example 1.
Application example 2
A mild anti-dandruff shampoo is prepared from the following components:
water, sodium laureth sulfate, disodium EDTA, and mild antidandruff compositions.
The preparation method of the mild anti-dandruff shampoo comprises the following steps:
82.66kg of water, 12kg of sodium laureth sulfate and 2kg of sodium laureth sulfate are weighed, put into an emulsifying pot, heated to 85 ℃, stirred for 30min at the rotating speed of 60r/min, cooled to 45 ℃, added with 0.04kg of disodium EDTA and 3.3kg of mild anti-dandruff composition, homogenized for 2min at 2500r/min at the rotating speed of 60r/, stirred for 5min, and the mild anti-dandruff shampoo is obtained.
Wherein the water is deionized water.
Wherein, laureth sulfate sodium comes from the market, CAS number: 9004-82-4.
Wherein, lauryl sodium sulfate is commercially available and has CAS number: 151-21-3.
Among them, disodium EDTA is commercially available and CAS number: 139-33-3.
Wherein the mild anti-dandruff composition is the mild anti-dandruff composition of example 2.
Application example 3
A mild anti-dandruff shampoo is prepared from the following components:
water, sodium laureth sulfate, disodium EDTA, and mild antidandruff compositions.
The preparation method of the mild anti-dandruff shampoo comprises the following steps:
82.16kg of water, 12kg of sodium laureth sulfate and 2kg of sodium laureth sulfate are weighed, put into an emulsifying pot, heated to 85 ℃ at a rotating speed of 60r/min, stirred for 30min, cooled to 45 ℃, added with 0.04kg of disodium EDTA and 3.8kg of mild anti-dandruff composition, homogenized for 2min at 2500r/min at a rotating speed of 60r/, stirred for 5min, and the mild anti-dandruff shampoo is obtained.
Wherein the water is deionized water.
Wherein, laureth sulfate sodium comes from the market, CAS number: 9004-82-4.
Wherein, lauryl sodium sulfate is commercially available and has CAS number: 151-21-3.
Among them, disodium EDTA is commercially available and CAS number: 139-33-3.
Wherein the mild anti-dandruff composition is the mild anti-dandruff composition of example 3.
Application example 4
A mild anti-dandruff shampoo which differs from application example 2 only in that:
wherein the mild anti-dandruff composition is the mild anti-dandruff composition of comparative example 1.
Application example 5
A mild anti-dandruff shampoo which differs from application example 2 only in that:
wherein the mild anti-dandruff composition is the mild anti-dandruff composition of comparative example 2.
Application example 6
A mild anti-dandruff shampoo which differs from application example 2 only in that:
wherein the mild anti-dandruff composition is the mild anti-dandruff composition of comparative example 3.
Application example 7
A mild anti-dandruff shampoo which differs from application example 2 only in that:
wherein the mild anti-dandruff composition is the mild anti-dandruff composition of comparative example 4.
Application example 8
A mild anti-dandruff shampoo which differs from application example 2 only in that:
wherein the mild anti-dandruff composition is the mild anti-dandruff composition of comparative example 5.
Application example 9
A mild anti-dandruff shampoo which differs from application example 2 only in that:
wherein the mild anti-dandruff composition is the mild anti-dandruff composition of comparative example 6.
Application example 10
A mild anti-dandruff shampoo which differs from application example 2 only in that:
wherein the mild anti-dandruff composition is the mild anti-dandruff composition of comparative example 7.
Experiment 1
According to the method of QB/T2738-2012 (evaluation method of antibacterial and bacteriostatic effects of daily chemical products) 7.5, the antibacterial effects of the mild anti-dandruff shampoo prepared by each application example are detected, and the antibacterial effects are evaluated according to the diameter of the antibacterial ring, and the larger the diameter of the antibacterial ring is, the better the antibacterial effects are.
Test strain: malassezia furfur, strain number: ATCC 44344.
When testing the antibacterial effect of mild anti-dandruff shampoo, the concentration of the bacterial suspension for test is 7.9x10 5 。
Experiment 2
The volunteers were summoned for several, the mild anti-dandruff shampoo of each application example was used in groups, every ten people were one group, the volunteers were shampooed with the mild anti-dandruff shampoo every two days, after 15 th use, no more hair was laundered, and the number of dandruff was tested at 1d, 3d, 7d after the hair washing.
When the dandruff test card is used for testing the number of the dandruff, the hairs are separated along the vertex center line to two sides to form a hair parting line, the dandruff test card is stuck to the hair parting line for 5s, the dandruff test card is taken down, the number of the dandruff adhered on the test card is recorded, and the average value of all groups of experimental data is obtained.
The specific detection data of experiments 1 and 2 are shown in Table 1.
TABLE 1
According to the comparison of the data in Table 1, the shampoo prepared from the anti-dandruff composition prepared by compounding the haw extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract has better antibacterial effect, the diameter of the antibacterial ring is larger, the inhibition effect on malassezia furfur is more obvious, the anti-dandruff effect is better, after the shampoo containing the anti-dandruff composition of each embodiment is used for washing hair for one month, the scalp is healthier, only a small amount of dandruff is generated after the shampoo is not used for washing hair for seven days, the hair appearance is not affected basically, the hair can be kept clean under lower washing frequency, and the hair is more attractive.
When any one of the hawthorn extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract is replaced by other extracts or is replaced by all the extracts, the antibacterial effect is slightly reduced, the effect of durably inhibiting dandruff is obviously reduced, more dandruff appears without washing hair for 3 days, the number of dandruff is obviously increased without washing hair for 7 days, the hair attractiveness is seriously influenced, and the hair attractiveness is difficult to maintain by consumers under lower hair washing frequency.
When the hawthorn extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract are extracted by adopting a special extraction method, the prepared shampoo has better lasting anti-dandruff effect, and when the shampoo is extracted by adopting a traditional water extraction method, the prepared shampoo is not obviously increased in the period of 3 days of stopping use, but the number of the dandruff is obviously increased in the period of 7 days of stopping use, and the durability of the dandruff is inhibited from being reduced.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.

Claims (4)

1. A mild anti-dandruff composition, characterized in that: is prepared from fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract by compounding;
the mass ratio of the haw extract, the kiwi fruit extract, the bunge cherry seed extract, the Yang Zaoshu skin extract and the willow herb extract is 5-7:7-9:4-6:8-10:3-5;
the preparation method of the haw extract comprises the following steps:
cutting fructus crataegi, freezing to below 0deg.C to obtain frozen fructus crataegi, adding into water, heating to boil, condensing and refluxing, extracting for 6-8 hr, filtering, collecting filtrate, concentrating, and drying to obtain fructus crataegi extract;
the preparation method of the kiwi fruit extract comprises the following steps:
crushing fructus Actinidiae chinensis into fructus Actinidiae chinensis pulp by wall breaking machine, adding fructus Actinidiae chinensis pulp into water, inoculating yeast, fermenting for 2-3d, heating to boiling, condensing and refluxing, extracting for 1-2h, filtering, collecting filtrate, concentrating the filtrate, and drying to obtain fructus Actinidiae chinensis extract;
the preparation method of the bunge cherry seed extract comprises the following steps:
cutting semen Pruni, adding into water, inoculating Aspergillus niger and Penicillium chrysogenum, soaking and extracting for 6-7d, heating to boil, condensing and refluxing, extracting for 2-3h, filtering, collecting filtrate, concentrating, and drying to obtain semen Pruni extract;
the preparation method of the Yang Zaoshu skin extract comprises the following steps:
cutting Yang Zaoshu skin, adding into water, inoculating Bacillus subtilis and Fusarium graminearum, soaking and extracting for 6-7d, heating to boil, condensing and refluxing, extracting for 2-3 hr, filtering, collecting filtrate, concentrating the filtrate, and drying to obtain Yang Zaoshu skin extract;
the preparation method of the willow herb extract comprises the following steps:
adding herba Salicis Babylonicae into 60-70% ethanol solution, heating to boiling, condensing and refluxing, extracting for 6-8 hr, recovering ethanol, filtering, collecting filtrate, concentrating the filtrate, and drying to obtain herba Salicis Babylonicae extract.
2. A process for the preparation of a mild anti-dandruff composition according to claim 1, wherein: the preparation method of the mild anti-dandruff composition comprises the following steps:
adding fructus crataegi extract, fructus Actinidiae chinensis extract, semen Pruni extract, yang Zaoshu skin extract, and herba Lipuidambaris extract into water, homogenizing for 5-8min, stirring for 30-40min, concentrating, and drying to obtain mild anti-dandruff composition.
3. Use of a mild anti-dandruff composition according to claim 1, characterized in that: the mild anti-dandruff composition is added into a washing and caring product for preparing the washing and caring product with mild anti-dandruff effect.
4. Use of a mild anti-dandruff composition according to claim 3, wherein: the addition mass percentage of the mild anti-dandruff composition in the washing and caring products is 2.7-3.7%.
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Citations (4)

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Publication number Priority date Publication date Assignee Title
KR20100029807A (en) * 2010-02-25 2010-03-17 주명신 Natural herbal composition for the prevention of depilation and improvement of hair growth and method for preparing the same
CN104146929A (en) * 2014-08-29 2014-11-19 宋鸟生 Dandruff-eliminating and itching-stopping liquid shampoo
CN105338991A (en) * 2013-08-22 2016-02-17 卢卡斯迈耶化妆品加拿大公司 Anti-dandruff compositions, and methods of use thereof
CN108670910A (en) * 2018-08-13 2018-10-19 花安堂生物科技集团有限公司 A kind of profit hair composition and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100029807A (en) * 2010-02-25 2010-03-17 주명신 Natural herbal composition for the prevention of depilation and improvement of hair growth and method for preparing the same
CN105338991A (en) * 2013-08-22 2016-02-17 卢卡斯迈耶化妆品加拿大公司 Anti-dandruff compositions, and methods of use thereof
CN111973641A (en) * 2013-08-22 2020-11-24 卢卡斯迈耶化妆品加拿大公司 Antidandruff compositions and methods of use thereof
CN104146929A (en) * 2014-08-29 2014-11-19 宋鸟生 Dandruff-eliminating and itching-stopping liquid shampoo
CN108670910A (en) * 2018-08-13 2018-10-19 花安堂生物科技集团有限公司 A kind of profit hair composition and preparation method thereof

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