CN116930527A - Sample analyzer and control method thereof - Google Patents
Sample analyzer and control method thereof Download PDFInfo
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- CN116930527A CN116930527A CN202210336397.6A CN202210336397A CN116930527A CN 116930527 A CN116930527 A CN 116930527A CN 202210336397 A CN202210336397 A CN 202210336397A CN 116930527 A CN116930527 A CN 116930527A
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- 238000000034 method Methods 0.000 title claims abstract description 18
- 238000001514 detection method Methods 0.000 claims abstract description 149
- 239000003153 chemical reaction reagent Substances 0.000 claims description 188
- 239000007788 liquid Substances 0.000 claims description 42
- 239000003792 electrolyte Substances 0.000 claims description 14
- 238000004891 communication Methods 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims description 2
- 230000000149 penetrating effect Effects 0.000 claims description 2
- 230000004308 accommodation Effects 0.000 claims 2
- 239000000523 sample Substances 0.000 description 230
- 238000006243 chemical reaction Methods 0.000 description 19
- 150000002500 ions Chemical class 0.000 description 19
- 230000007246 mechanism Effects 0.000 description 16
- 238000010586 diagram Methods 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 8
- 238000011068 loading method Methods 0.000 description 7
- 238000002156 mixing Methods 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 239000012086 standard solution Substances 0.000 description 5
- 239000012295 chemical reaction liquid Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 239000012470 diluted sample Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 230000007704 transition Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 238000005353 urine analysis Methods 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 238000009535 clinical urine test Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229910001414 potassium ion Inorganic materials 0.000 description 1
- -1 potassium ions Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000012088 reference solution Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910001415 sodium ion Inorganic materials 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/4166—Systems measuring a particular property of an electrolyte
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/025—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having a carousel or turntable for reaction cells or cuvettes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
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- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
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Abstract
The embodiment of the application provides a sample analyzer and a control method of the sample analyzer, wherein the sample analyzer comprises a control component, a containing device, a sample adding component for adding a sample into the containing device, a first power piece and a detection component; the first power piece is connected with the first interface through a connecting pipeline, and the detection assembly is connected with the second interface; the control component is used for controlling the sample adding component to add samples into the accommodating device, controlling the first power piece to absorb part of the samples in the accommodating device from the first interface and obtaining a detection result obtained by detecting the residual samples in the accommodating device by the detection component; the air bubbles in the sample are reduced by sucking part of the sample from the holding device, so that the sample discharged to the detection assembly contains no air bubbles or fewer air bubbles, and the interference of the air bubbles on detection is reduced or eliminated.
Description
Technical Field
The application relates to the technical field of medical equipment, in particular to a sample analyzer and a control method of the sample analyzer.
Background
Sample analyzers for detecting samples, such as electrolyte analyzers for detecting and maintaining the concentration of ions (mainly including na+, k+, cl-ions) in human blood, are essential in clinical tests.
The sample cup is used as a container for carrying the sample, and when the sample is added into the sample cup, bubbles can be generated in the sample due to phenomena such as turbulence, and the existence of the bubbles can interfere with the detection of the sample, so that the detection result is inaccurate.
Disclosure of Invention
The application provides a sample analyzer, which aims to solve the technical problems that a sample in a sample cup has bubble interference, so that a detection result is inaccurate and the like.
In a first aspect, an embodiment of the present application provides a sample analyzer, including:
the sample adding component is used for adding a sample into the accommodating device;
the accommodating device is provided with a first interface and a second interface, and the height of the second interface on the accommodating device is lower than or equal to that of the first interface;
the first power piece is connected with the first interface through a connecting pipeline;
the detection component is connected with the second interface and is used for detecting a sample in the accommodating device;
The control component is used for controlling the sample adding component to add samples into the accommodating device, controlling the first power piece to absorb part of the samples in the accommodating device from the first interface and obtaining detection results obtained by detecting the residual samples in the accommodating device by the detection component.
In a second aspect, an embodiment of the present application provides a method for controlling a sample analyzer, including:
adding a sample to the holding device;
sucking part of the sample in the accommodating device from a first interface, close to the bottom, of the accommodating device;
and detecting the residual sample in the accommodating device to obtain a detection result.
The embodiment of the application provides a sample analyzer and a control method of the sample analyzer, wherein the sample analyzer comprises a control component, a containing device, a sample adding component for adding a sample into the containing device, a first power piece and a detection component; the first power piece is connected with the first interface through a connecting pipeline, and the detection assembly is connected with the second interface; the control component is used for controlling the sample adding component to add samples into the accommodating device, controlling the first power piece to absorb part of the samples in the accommodating device from the first interface and obtaining a detection result obtained by detecting the residual samples in the accommodating device by the detection component; the suction of a portion of the sample in the receiving device from the first interface by the first power member reduces the air bubbles in the sample such that the sample contains no or less air bubbles when the sample is discharged to the detection assembly through the second interface, thereby reducing or eliminating the interference of the air bubbles to the detection.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the disclosure of embodiments of the application.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for the description of the embodiments will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present application, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic diagram of a sample analyzer according to an embodiment of the present application;
FIG. 2 is a schematic block diagram of a sample analyzer in one embodiment;
FIG. 3 is a schematic block diagram of a sample analyzer in another embodiment;
FIG. 4 is a schematic diagram of a sample analyzer in one embodiment;
FIG. 5 is a schematic diagram of a sample analyzer in another embodiment;
FIG. 6 is a schematic diagram of an embodiment of the loading assembly loading a sample into a receiving device;
FIG. 7 is a schematic view of another embodiment of the loading assembly loading a sample into a receiving device;
FIG. 8 is a schematic diagram of the operation of the sample analyzer in one embodiment;
Fig. 9 is a flowchart of a control method of a sample analyzer according to another embodiment of the present application.
Reference numerals illustrate:
110. a sample application assembly; 111. a sample needle; 120. a receiving device; 121. a first interface; 122. a second interface; 1201. a connecting pipeline; 123. a third interface; 124. a liquid outlet; 125. a liquid discharge channel; 130. a first power member; 140. a detection assembly; 150. a control assembly; 160. a second power member; 170. a third power member; 101. a gas column; 200. a reagent container;
10. a functional module; 11. a sample member; 12. a sample dispensing mechanism; 13. a reagent component; 14. a reagent dispensing mechanism; 15. a mixing mechanism; 16. a reaction member; 17. a light measurement unit; 20. an input module; 30. a display module; 40. a memory; 50. a processor; 60. and an alarm module.
Detailed Description
The following description of the embodiments of the present application will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are some, but not all embodiments of the application. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
The flow diagrams depicted in the figures are merely illustrative and not necessarily all of the elements and operations/steps are included or performed in the order described. For example, some operations/steps may be further divided, combined, or partially combined, so that the order of actual execution may be changed according to actual situations.
Some embodiments of the present application are described in detail below with reference to the accompanying drawings. The following embodiments and features of the embodiments may be combined with each other without conflict.
Referring to fig. 1, fig. 1 is a schematic structural diagram of a sample analyzer according to an embodiment of the application.
In some embodiments, the sample analyzer includes, but is not limited to, at least one of: electrolyte analyzer, biochemical analyzer, immunoassay analyzer, coagulation analyzer, urine analyzer. The electrolyte analyzer is, for example, an ISE (Ion Selective Electrode, ionic electrode) analyzer.
Illustratively, the sample analyzer is an ISE analysis module in a biochemical analyzer, which may further include at least one of an immunoassay module, a coagulation analysis module, a urine analysis module, and the like.
Before explaining the present application in detail, a description will be given of the structure of a sample analyzer in some embodiments.
Referring to fig. 2, an embodiment discloses a sample analyzer, which includes at least one functional module 10 (or one or more functional modules 10), an input module 20, a display module 30, a memory 40, a processor 50, and an alarm module 60, which are described below.
Each functional module 10 is used for performing at least one function required in the sample analysis process, and the functional modules 10 cooperate together to perform the sample analysis to obtain a sample analysis result. Referring to fig. 3, a sample analyzer according to an embodiment is shown, in which some examples of the functional module 10 are provided. For example, the functional module 10 may include a sample block 11, a sample dispensing mechanism 12, a reagent block 13, a reagent dispensing mechanism 14, a mixing mechanism 15, a reaction block 16, a photometric block 17, and the like.
The sample part 11 is used for carrying a sample. Sample assembly 11 may include sample distribution modules (SDM, sample Delivery Module) and front end rails in some examples; in other examples, the sample portion 10 may be a sample tray that includes a plurality of sample locations where samples, such as sample tubes, may be placed, and the sample tray may be rotated to dispense samples to corresponding locations, such as where the sample dispensing mechanism 12 draws samples.
The sample dispensing mechanism 12 is used to aspirate and discharge a sample into a reaction cup to be loaded. For example, the sample dispensing mechanism 12 may comprise a sample needle that is moved in two or three dimensions spatially by a two or three dimensional drive mechanism so that the sample needle can be moved to aspirate the sample carried by the sample part 11 and to move to the cuvette to be loaded and discharge the sample to the cuvette.
The reagent component 13 is for carrying a reagent. In one embodiment, the reagent component 13 may be a reagent disk, where the reagent disk is configured in a disk-shaped structure and has a plurality of positions for carrying reagent containers, and the reagent component 13 can rotate and drive the reagent containers carried by the reagent component to rotate to a specific position, for example, a position where the reagent is sucked by the reagent dispensing mechanism 14. The number of reagent parts 13 may be one or more.
The reagent dispensing mechanism 14 is used to aspirate and discharge the reagent into the cuvette to be filled with the reagent. In one embodiment, the reagent dispensing mechanism 14 may comprise a reagent needle that is moved in two or three dimensions spatially by a two or three dimensional drive mechanism so that the reagent needle can be moved to aspirate the reagent carried by the reagent component 13 and to move to and discharge the reagent to the cuvette to be filled with the reagent.
The mixing mechanism 15 is used for mixing the reaction liquid to be mixed in the reaction cup. The number of mixing mechanisms 15 may be one or more.
The reaction part 16 has at least one place for placing a reaction cup and incubating the reaction liquid in the reaction cup. For example, the reaction component 16 may be a reaction disk, which is arranged in a disk-like structure, and has one or more placement sites for placing reaction cups, and the reaction disk can rotate and drive the reaction cups in the placement sites to rotate, so as to schedule the reaction cups in the reaction disk and incubate the reaction liquid in the reaction cups.
The photodetection unit 17 is configured to photodetect the reaction solution after incubation, and obtain reaction data of the sample. For example, the photodetection means 17 detects the luminescence intensity of the reaction solution to be measured, and calculates the concentration of the component to be measured in the sample from the calibration curve. In one embodiment, the photodetection part 17 is separately provided outside the reaction part 16.
The foregoing is illustrative of some of the functional modules 10 and the following continues with a description of other components and structures in the sample analyzer.
The input module 20 is for receiving input from a user. Typically, the input module 20 may be a mouse, a keyboard, etc., and in some cases may also be a touch display screen, which brings about functions for a user to input and display content, so that in this example the input module 20 and the display module 30 are integrated. Of course, in some examples, the input module 20 may even be a voice input device or the like that brings up recognition voice.
The display module 30 may be used to display information. In some embodiments, the sample analyzer itself may incorporate a display module, and in some embodiments, the sample analyzer may be connected to a computer device (e.g., a computer) for displaying information via a display unit (e.g., a display screen) of the computer device, which falls within the scope of the display module 30 herein defined and protected.
For convenience of explanation, a sample analyzer is mainly used as an electrolyte analyzer, such as an ISE analyzer. Compared with other ion detection equipment, such as an atomic absorption spectrophotometer, an ICP (Inductively Coupled Plasma ) mass spectrometer, an ion chromatograph and the like, the electrolyte analysis instrument has the advantages of high precision, good accuracy, high speed, simplicity in operation and the like.
As shown in fig. 1, the sample analyzer includes a loading module 110, a receiving device 120, a first power member 130, a detection module 140, and a control module 150.
Wherein, the sample adding component 110 is used for adding a sample to the accommodating device 120. For example, the sample adding component 110 may be used to add a serum sample to the accommodating device 120, but is not limited thereto, and may be, for example, whole blood, plasma, urine, dialysate, hydration liquid, or the like.
Specifically, the accommodating device 120 is provided with a first interface 121 and a second interface 122, and the height of the second interface 122 on the accommodating device 120 is lower than or equal to the first interface 121.
The second interface 122 is connected to the detection component 140, and the detection component 140 is configured to detect a sample in the accommodating device 120. Specifically, the control component 150 is configured to control the sample adding component 110 to add a sample to the accommodating device 120, control the first power component 130 to draw a portion of the sample in the accommodating device 120 from the first interface 121, and obtain a detection result obtained by detecting the remaining sample in the accommodating device 120 by the detection component 140.
In some embodiments, as shown in fig. 4, the sample analyzer further includes a second power member 160, where the second power member 160 is in communication with the second interface 122 and the detection assembly 140, so that the liquid in the accommodating device 120 is discharged by the second interface 122 under the action of the second power member 160 to flow through the detection assembly 140 for detection. Illustratively, the sample analyzer is an ase analysis module in a biochemical analyzer, which may further include at least one of an immunoassay module, a coagulation analysis module, a urine analysis module, and the like.
Illustratively, the control component 150 obtains the detection result obtained by the detection component 140 detecting the remaining samples in the accommodating device 120: the second power member 160 is controlled to operate, so that the remaining sample in the accommodating device 120 is discharged through the second interface 122 to flow through the detecting component 140 for detection, and a detection result obtained by the detecting component 140 is obtained.
Illustratively, the sensing component 140 is an electrolyte sensing component 140, e.g., the sensing component 140 includes sensing electrodes, such as an indicator electrode and a reference electrode. When the liquid in the accommodating device 120 is an electrolyte containing ions, such as a serum sample, when flowing through the detecting component 140, an electrode potential difference, i.e. an electric potential, is formed between the indicating electrode and the reference electrode of the detecting component 140, and the ion concentration of the sample can be determined according to the detected electric potential of the sample. Alternatively, the ion concentration of the sample may be determined from the potential of the sample being detected and the potential of the reagent of known ion concentration, which may be referred to as a direct method; or the sample is a diluted sample of the diluent, and the ion concentration of the sample before dilution is determined according to the potential of the diluted sample and the potential of the diluent, which can be called an indirect method.
Alternatively, the indicator electrode is an ion selective electrode, and the concentration of different ions, such as potassium ions, sodium ions, chloride ions, can be measured by different ion selective electrodes.
Referring to fig. 4, when the sample loading assembly 110 loads a sample into the accommodating device 120, there is a probability that the sample in the accommodating device 120 will have bubbles, and the sample mixed with bubbles flows through the detecting assembly 140 to be detected, so that the detection result obtained by the detection is inaccurate. Based on the finding of this technical problem, the inventor of the present application improves the accommodating device 120, specifically, the accommodating device 120 is provided with the first interface 121, and the sample mixed with the air bubbles can be discharged through the first interface 121, so that when the sample is discharged to the detecting component 140 through the second interface 122, the sample contains no air bubbles or contains fewer air bubbles, so as to reduce or eliminate the interference of the air bubbles on the detection.
As shown in fig. 1 and 4, the first port 121 is connected to the first power member 130 through a connecting pipe 1201. The first power member 130 may, for example, comprise a liquid pump, and a portion of the sample in the receiving device 120 may be drawn from the first interface 121 by the first power member 130. Referring to fig. 4, the surface of the sample in the accommodating device 120 contains some bubbles, the height of the first interface 121 on the accommodating device 120 is higher than or equal to the height of the second interface 122 on the accommodating device 120, so that the liquid containing bubbles at the upper part of the sample can be sucked, and the sample at the lower part of the accommodating device is discharged to the detecting component 140 through the second interface 122, wherein the sample at the lower part contains no bubbles or only fewer bubbles.
In some embodiments, referring to fig. 4, the first power member 130 is further configured to inject the first reagent in the reagent container 200 into the accommodating device 120 through the first interface 121.
Illustratively, the first reagent can be used to clean the containment device 120, the detection assembly 140, and/or to scale the detection assembly 140. For example, the first reagent includes an internal standard solution, a cleaning solution, a dilution solution, a reference solution, and the like, but is not limited thereto.
In some embodiments, the control assembly 150 is further configured to, prior to controlling the loading assembly 110 to load the sample into the holding device 120: the first power member 130 is controlled to draw air from the first port 121 to form the air column 101. That is, after the first power member 130 is controlled to draw air from the first interface 121 to form the air column 101, the sample adding assembly 110 is controlled to add a sample into the accommodating device 120, and the first power member 130 is controlled to draw a part of the sample in the accommodating device 120 from the first interface 121. Referring to fig. 4, the gas column 101 may form a separation between the first reagent provided by the reagent container 200 and the sample sucked from the container 120, preventing contamination of the first reagent by the sample.
In some embodiments, the control assembly 150 controls the operation of the second power member 160 to expel the remaining sample from the receiving device 120 through the second interface 122 for detection by the detection assembly 140: the first power member 130 is controlled to inject the sample sucked from the first interface 121 into the receiving device 120, and the second power member 160 is controlled to discharge the sample in the receiving device 120. After the sample is detected, the sample sucked from the first interface 121 is discharged, optionally, the sucked sample and air are discharged, and the first power member 130 can be controlled to discharge a quantity of the first reagent so as to clean the connecting pipeline 1201 and the first interface 121, and sample residues are removed.
In some implementations, the control assembly 150 may further control the first power member 130 to inject the first reagent in the reagent container 200 into the accommodating device 120 through the first interface 121, and control the second power member 160 to drain the first reagent in the accommodating device 120 through the detecting assembly 140, so as to obtain a detection result of the first reagent. The detection result of the first reagent may be used for reagent calibration, such as or may be used for calibration of the detection result of the sample. Alternatively, the sample analyzer is an electrolyte analyzer and/or the detection component 140 is an electrolyte detection component 140, and the first reagent may be referred to as an a-standard solution.
Illustratively, after controlling the second power member 160 to expel the first reagent in the accommodating device 120 through the detecting assembly 140, the detecting result of the first reagent is obtained: the control component 150 is further configured to determine a target result of the sample according to the detection result of the sample and the detection result of the first reagent. For example, the detection result of the sample is calibrated according to the detection result of the first reagent, so that the interference of the difference of the first reagent on the detection result of the sample is reduced or eliminated, and the accuracy of the detection result of the sample is improved.
In some embodiments, when the control component 150 obtains a detection result obtained by detecting the remaining sample in the accommodating device 120 by the detection component 140, a first potential of the sample detected by the detection component 140 is obtained; acquiring a second potential of the first reagent detected by the detection component 140 when the detection component 140 acquires a detection result of the first reagent; when a target result of the sample is determined based on the detection result of the sample and the detection result of the first reagent, electrolyte information of the sample is obtained based on the first potential and the second potential.
Illustratively, the ion concentration in the sample is determined from the ion concentration of the first reagent and the second potential of the first reagent, and the first potential of the sample.
Optionally, after controlling the first power member 130 to inject the sample sucked from the first interface 121 into the accommodating device 120 and controlling the second power member 160 to discharge the sample in the accommodating device 120, the control assembly 150 controls the first power member 130 to inject the first reagent in the reagent container 200 into the accommodating device 120 through the first interface 121 and controls the second power member 160 to discharge the first reagent in the accommodating device 120 through the detecting assembly 140, so as to obtain a detection result of the first reagent. The accuracy of the detection result of the first reagent can be improved by injecting the first reagent after the sample is discharged and detecting the first reagent.
In some embodiments, the control assembly 150 is further configured to control the operation of the first power member 130 to inject the first reagent in the reagent container 200 into the receiving device 120 through the first interface 121, and to control the operation of the second power member 160 to expel the first reagent in the receiving device 120. The first reagent washes the receiving means 120 while passing through the receiving means 120. Alternatively, the control assembly 150 may control the operation of the second power member 160 to expel the first reagent from the receptacle 120 and the detection assembly 140 for cleaning the receptacle 120 and the detection assembly 140.
For example, the control assembly 150 may control the first power member 130 to operate to inject the first reagent in the reagent container 200 into the receiving device 120 through the first interface 121 after controlling the second power member 160 to discharge the sample in the receiving device 120, and control the second power member 160 to operate to discharge the first reagent in the receiving device 120. After the sample is discharged, the accommodating device 120 and the detecting assembly 140 are cleaned, so that the cleaning efficiency can be improved, and the first reagent can be saved.
Optionally, after the first reagent washes the accommodating device 120, the control component 150 controls the first power component 130 to inject the first reagent in the reagent container 200 into the accommodating device 120 through the first interface 121, and controls the second power component 160 to drain the first reagent in the accommodating device 120 to flow through the detecting component 140, so as to obtain a detection result of the first reagent, which can reduce or eliminate the influence of the sample residue on the detection of the first reagent, and improve the accuracy of the detection result of the first reagent.
For example, when the first power member 130 is controlled to operate to inject the first reagent in the reagent container 200 into the receiving device 120 through the first interface 121, and the second power member 160 is controlled to operate to discharge the first reagent in the receiving device 120, the rotation speed of the first power member 130 is less than or equal to the rotation speed of the second power member 160. When the flow rate of the first reagent in the second power part 160 discharged from the accommodating device 120 is greater than the flow rate of the first reagent injected into the accommodating device 120 by the first power part 130, the second power part 160 can absorb part of the air through the second interface 122 to form a gas-liquid mixture with the absorbed first reagent, and the gas-liquid mixture can quickly pass through the pipeline, the second power part 160 and the detection assembly 140 connected with the second interface 122, so that the pipeline, the second power part 160 and the detection assembly 140 can be flushed with higher efficiency to reduce the residue of the sample.
Optionally, when the first power member 130 is controlled to operate to inject the first reagent in the reagent container 200 into the accommodating device 120 through the first interface 121, and the second power member 160 is controlled to operate to discharge the first reagent in the accommodating device 120, the liquid level of the first reagent in the accommodating device 120 is set to Yu Xiangrong at least at one time to the liquid level of the sample when the sample is added to the accommodating device 120.
For example, the first power member 130 may be controlled to inject a predetermined volume of the first reagent into the accommodating device 120, where the predetermined volume is greater than the volume of the sample when the sample is added to the accommodating device 120, so that the liquid level of the first reagent is Yu Xiangrong higher than the liquid level of the sample when the sample is added to the accommodating device 120; the second power member 160 is then controlled to operate to expel the first reagent from the receiving means 120, or both the first power member 130 is controlled to inject the first reagent and the second power member 160 is controlled to expel the first reagent. Of course, the present invention is not limited thereto, and for example, the rotation speed of the first power member 130 may be controlled to be greater than the rotation speed of the second power member 160, so that the liquid level Yu Xiangrong of the first reagent in the accommodating device 120 is higher than the liquid level of the sample when the sample is added into the accommodating device 120, and the accommodating device 120 is cleaned sufficiently; and then the rotation speed of the first power piece 130 is controlled to be smaller than that of the second power piece 160, so that the second power piece 160 sucks part of air through the second interface 122 to form a gas-liquid mixture with the sucked first reagent, and the efficiency of flushing the pipeline, the second power piece 160 and the detection assembly 140 is improved.
In some embodiments, referring to fig. 5 and 6, the accommodating device 120 is further provided with a third interface 123. The third interface 123 is used for injecting a second reagent, which is different from the first reagent. Illustratively, the second reagent has a lower ion concentration than the first reagent; for example, the second reagent and the first reagent are standard solutions of known concentrations. Alternatively, the sample analyzer is an electrolyte analyzer and/or the detection assembly 140 is an electrolyte detection assembly 140, the first reagent may be referred to as an a-standard solution and the second reagent may be referred to as a B-standard solution.
Illustratively, as shown in fig. 5, the sample analyzer further includes a third power member 170, the third power member 170 being configured to inject a second reagent in the reagent container 200 into the receiving device 120 through the third interface 123.
In some embodiments, after controlling the second power member 160 to discharge the first reagent in the accommodating device 120 through the detection assembly 140 to obtain the detection result of the first reagent, the control assembly 150 is further configured to control the third power member 170 to inject the second reagent in the reagent container 200 into the accommodating device 120 through the third interface 123, and control the second power member 160 to discharge the second reagent in the accommodating device 120 through the detection assembly 140 to obtain the detection result of the second reagent; and the control component 150 is further configured to adjust an electrode slope of the detection component according to the detection result of the first reagent and the detection result of the second reagent.
Illustratively, the control component 150, when acquiring the detection result of the second reagent by the detection component 140, acquires the third potential of the second reagent detected by the detection component 140; the control component 150 is configured to adjust the electrode slope of the detection component 140, for example, adjust the slope of the curve of the ion concentration and the potential, according to the ion concentration of the first reagent and the second potential, and the ion concentration of the second reagent and the third potential, when adjusting the electrode slope of the detection component according to the detection result of the first reagent and the detection result of the second reagent; and based on the adjusted electrode slope, determining the ion concentration in the sample from the first potential of the sample.
In some embodiments, as shown in fig. 5 and 6, the third interface 123 is higher than or equal to the first interface 121 on the receiving device 120. Contamination of the third interface 123 during use of the first reagent can be prevented. Illustratively, the third interface 123 is at a height above the receptacle 120 that is greater than the liquid level of the first reagent when the first reagent is injected into the receptacle 120.
Illustratively, the first reagent is used more frequently than the second reagent, e.g., during testing, such as in a serum test or a urine test, where single point calibration would be used; by setting the height of the first interface 121 of the first reagent to be higher than the third interface 123 of the second reagent, cross-contamination of the third interface 123 during use of the first reagent can be prevented.
Optionally, before controlling the third power member 170 to inject the second reagent in the reagent container 200 into the accommodating device 120 through the third interface 123, the control assembly 150 is further configured to control the first power member 130 to draw air from the first interface 121 to form a gas column. That is, after the first power member 130 is controlled to draw air from the first interface 121 to form an air column, the third power member 170 is controlled to add the second reagent into the accommodating device 120, and the second power member 160 is controlled to discharge the second reagent in the accommodating device 120 to flow through the detecting component 140, so as to obtain a detection result of the second reagent. The second reagent injected into the receiving means 120 through the third port 123 can be prevented from being contaminated by the first reagent while flowing through the first port 121.
In some embodiments, referring to fig. 6, the bottom wall of the accommodating cavity formed by the accommodating device 120 is provided with a liquid outlet 124, the sample analyzer further includes a liquid discharge channel 125 penetrating the bottom of the sample container and communicating with the liquid outlet 124, the first interface 121 is disposed on a sidewall of the liquid discharge channel 125, and the second interface 122 is disposed on a sidewall of the liquid discharge channel 125 or at the bottom end of the liquid discharge channel 125 as the second interface 122. When the sample is injected into the accommodating cavity formed by the accommodating device 120, bubbles are likely to be generated at the bottom wall of the accommodating cavity, the sample with the bubbles is sucked through the first interface 121 and the liquid discharge channel 125, and then the sucked sample is sucked from the second interface 122 by controlling the second power member 160, so that the sucked sample contains no bubbles or fewer bubbles, and the interference of the bubbles on the detection of the sample by the detection component 140 is reduced or eliminated.
As shown in fig. 6, the side wall of the accommodating device 120 is formed with a flow guiding surface, when the sample is added to the accommodating device 120 by the sample adding component 110, the added sample can flow along the flow guiding surface of the side wall to the bottom wall of the accommodating cavity, for example, the sample can flow through the conical flow guiding surface, so that bubbles are prevented from being generated due to turbulence when the liquid is directly injected into the bottom of the accommodating device 120.
Optionally, the volume of the accommodating device 120 corresponding to the flow guiding surface below the third interface 123 is greater than or equal to the maximum volume of the sample when the accommodating device 120 injects the sample, so as to prevent the sample from polluting the third interface 123.
Optionally, the volume of the accommodating device 120 corresponding to the flow guiding surface below the third interface 123 is greater than or equal to the maximum volume of the first reagent when the accommodating device 120 injects the first reagent, so as to prevent the first reagent from polluting the third interface 123.
Optionally, as shown in fig. 6, the diversion surface and the side wall of the liquid discharge channel 125 are in rounded transition, for example, the accommodating device 120 is in rounded transition of R3 at the junction of the taper angle wall surface and the vertical wall surface, so that the liquid on the diversion surface slides down to the liquid discharge channel 125, and air bubbles are prevented from being generated by collecting the liquid between the diversion surface and the side wall of the liquid discharge channel 125.
Optionally, the roughness of the diversion surface is less than or equal to Ra0.1, so as to reduce the residual quantity of the sample and reduce the cross contamination.
In some embodiments, referring to fig. 6 and 7, the sample addition assembly 110 includes a sample needle 111, the sample needle 111 for adding a sample to the receiving device 120 through the top opening of the receiving device 120; the liquid discharge axis of the sample needle 111 when filling the holding device 120 does not overlap with the projection of the center of the second port 122 on the horizontal plane. For example, when the sample needle 111 is discharged to the container 120, the sample needle 111 is deviated from the position directly above the second port 122 of the container 120. The sample discharged from the sample needle 111 to the accommodating device 120 is not directly dropped to the second interface 122, so that bubbles can be prevented from being generated at the second interface 122, and the sample does not contain bubbles or contains fewer bubbles when the sample is sucked from the second interface 122 to the detection assembly 140, so that the interference of the bubbles on the detection result is reduced.
For example, referring to fig. 6 and 7, a side wall of the accommodating device 120 is formed with a guide surface, and when the sample needle 111 deflects from a direction directly above the second port 122 to add the sample into the accommodating device 120, the sample flows along the guide surface toward the bottom of the accommodating device 120. The sample is guided by the guiding surface, so that bubbles generated due to turbulence can be prevented when the liquid is directly injected into the bottom of the accommodating device 120.
Alternatively, as shown in fig. 7, the lower edge of the guide surface extends to the bottom of the accommodating device 120. The liquid discharged from the sample application assembly 110 can slide to the bottom of the accommodating device 120 via the flow guiding surface, so as to prevent bubbles from being generated at the bottom of the accommodating device 120.
In some embodiments, the sample application assembly 110 communicates with the receiving chamber of the receiving device 120 via a fourth interface (not shown) provided on the receiving device 120, for example, the sample application line and the power member may be connected at the fourth interface, and the power member is controlled to operate so as to apply the sample into the receiving chamber via the fourth interface. Illustratively, the height of the fourth interface on the accommodating device 120 is lower than or equal to the upper edge of the guiding surface, so as to prevent bubbles from being generated during sample application.
In some implementations, referring to fig. 5 and 8, the workflow of the sample analyzer according to the embodiment of the present application includes the following steps S11 to S19.
S11, controlling the first power piece 130 to inject the first reagent into the accommodating device 120 and controlling the second power piece 160 to discharge the first reagent in the accommodating device 120 so as to wash the accommodating device 120;
s12, controlling the first power piece 130 to suck air from the first interface 121 to form an air column 101;
S13, controlling the sample adding component 110 to add a sample into the accommodating device 120;
s14, controlling the first power piece 130 to absorb part of the sample in the accommodating device 120 from the first interface 121;
s15, controlling the second power piece 160 to discharge the sample in the accommodating device 120 to flow through the detection assembly 140 for detection, and obtaining a detection result of the sample;
s16, controlling the first power piece 130 to inject the sample sucked from the first interface 121 into the accommodating device 120, and controlling the second power piece 160 to discharge the sample in the accommodating device 120;
s17, controlling the first power piece 130 to inject the first reagent into the accommodating device 120 and controlling the second power piece 160 to discharge the first reagent in the accommodating device 120 so as to wash the accommodating device 120;
s18, controlling the first power piece 130 to inject the first reagent into the accommodating device 120, and controlling the second power piece 160 to discharge the first reagent in the accommodating device 120 to flow through the detection assembly 140, so as to obtain a detection result of the first reagent;
s19, determining a target result of the sample according to the detection result of the sample and the detection result of the first reagent.
It should be noted that some steps in the workflow shown in fig. 8 may not be performed every time the sample is detected, as in step S18; alternatively, the workflow of the sample analyzer may further include steps other than those shown in fig. 8, for example, the third power member 170 may be controlled to inject the second reagent in the reagent container 200 into the accommodating device 120, and the second power member 160 may be controlled to discharge the second reagent in the accommodating device 120 through the detecting component 140, so as to obtain a detection result of the second reagent.
The sample analyzer provided by the embodiment of the application comprises a control component, a containing device, a sample adding component for adding a sample into the containing device, a first power piece and a detection component; the first power piece is connected with the first interface through a connecting pipeline, and the detection assembly is connected with the second interface; the control component is used for controlling the sample adding component to add samples into the accommodating device, controlling the first power piece to absorb part of the samples in the accommodating device from the first interface and obtaining a detection result obtained by detecting the residual samples in the accommodating device by the detection component; the suction of a portion of the sample in the receiving device from the first interface by the first power member reduces the air bubbles in the sample such that the sample contains no or less air bubbles when the sample is discharged to the detection assembly through the second interface, thereby reducing or eliminating the interference of the air bubbles to the detection.
Referring to fig. 9 in combination with the foregoing embodiments, fig. 9 is a flow chart of a control method of a sample analyzer according to an embodiment of the application.
As shown in fig. 9, the control method includes the following steps S110 to S130.
Step S110, adding a sample into the accommodating device;
step S120, sucking part of samples in the accommodating device from a first interface, close to the bottom, of the accommodating device;
step S130, detecting the remaining samples in the accommodating device to obtain a detection result.
Illustratively, the control method includes controlling the sample addition assembly to add a sample to the containment device; controlling a first power piece to absorb part of samples in the accommodating device from a first interface of the accommodating device; and obtaining a detection result obtained by detecting the residual sample in the accommodating device by the detection component.
In some embodiments, prior to adding the sample to the holding device, further comprising: air is sucked from the first interface to form an air column.
In some embodiments, the detection result obtained by detecting the remaining sample in the accommodating device includes:
and discharging the residual sample in the accommodating device from a second interface of the accommodating device to flow through a detection component of the sample analyzer for detection.
In some embodiments, before the controlling the sample addition assembly to add the sample to the holding device, further comprising:
controlling the first power piece to suck air from the first interface to form an air column.
In some embodiments, the obtaining a detection result obtained by the detection component through detecting the remaining samples in the accommodating device includes:
and controlling the second power piece to operate so as to discharge the residual sample in the accommodating device from the second interface of the accommodating device to flow through the detection assembly for detection.
In some embodiments, after the controlling the operation of the second power member to expel the remaining sample in the receptacle from the second interface of the receptacle for detection by flowing through the detection assembly, the control method further comprises:
controlling the first power member to inject the sample sucked from the first interface into the accommodating device, and controlling the second power member to discharge the sample in the accommodating device;
controlling the first power part to operate so as to inject a first reagent in a reagent container into the accommodating device through the first interface, and controlling the second power part to operate so as to discharge the first reagent in the accommodating device;
and controlling the first power piece to inject the first reagent in the reagent container into the accommodating device through the first interface, and controlling the second power piece to drain the first reagent in the accommodating device to flow through the detection assembly, so as to obtain a detection result of the first reagent.
The specific principle and implementation manner of the control method provided by the embodiment of the present application are similar to those of the sample analyzer in the foregoing embodiment, and are not repeated here.
It is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application.
It should also be understood that the term "and/or" as used in the present application and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.
While the application has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the application. Therefore, the protection scope of the application is subject to the protection scope of the claims.
Claims (16)
1. A sample analyzer, comprising:
the sample adding component is used for adding a sample into the accommodating device;
the accommodating device is provided with a first interface and a second interface, and the height of the second interface on the accommodating device is lower than or equal to that of the first interface;
The first power piece is connected with the first interface through a connecting pipeline;
the detection component is connected with the second interface and is used for detecting a sample in the accommodating device;
the control component is used for controlling the sample adding component to add samples into the accommodating device, controlling the first power piece to absorb part of the samples in the accommodating device from the first interface and obtaining detection results obtained by detecting the residual samples in the accommodating device by the detection component.
2. The sample analyzer of claim 1, wherein the first power member is further configured to inject a first reagent in a reagent container into the receiving device through the first interface.
3. The sample analyzer of claim 2, wherein the control assembly is further configured to, prior to controlling the sample addition assembly to add a sample to the receiving device:
controlling the first power piece to suck air from the first interface to form an air column.
4. The sample analyzer of claim 2, further comprising a second power element in communication with the second interface and the detection assembly for draining the liquid in the container device from the second interface for detection by the detection assembly, wherein the control assembly obtains a detection result obtained by detecting the remaining sample in the container device by the detection assembly:
And controlling the second power piece to operate so as to discharge the residual sample in the accommodating device from the second interface to flow through the detection assembly for detection.
5. The sample analyzer of claim 4, wherein the control assembly controls operation of the second power member to expel a remaining sample in the receiving device from the second interface for detection by the detection assembly after:
controlling the first power member to inject the sample sucked from the first interface into the accommodating device, and controlling the second power member to discharge the sample in the accommodating device;
controlling the first power part to inject a first reagent in the reagent container into the accommodating device through the first interface, and controlling the second power part to discharge the first reagent in the accommodating device to flow through the detection assembly, so as to obtain a detection result of the first reagent;
and determining a target result of the sample according to the detection result of the sample and the detection result of the first reagent.
6. The sample analyzer of claim 5, wherein the control assembly controls the second power member after expelling the sample from the receiving device and/or controls the first power member before injecting the first reagent from the reagent container into the receiving device through the first interface:
Controlling the first power part to operate so as to inject the first reagent in the reagent container into the accommodating device through the first interface, and
and controlling the second power piece to operate so as to discharge the first reagent in the accommodating device.
7. The sample analyzer of claim 6, wherein the first power member is controlled to operate to inject a first reagent in the reagent container into the receiving device through the first interface, and the second power member is controlled to operate to rotate at a speed less than or equal to a speed of the second power member when the first reagent in the receiving device is discharged.
8. The sample analyzer of claim 6, wherein the first power member is controlled to operate to inject a first reagent in the reagent container into the holding device through the first interface, and the second power member is controlled to operate to expel the first reagent in the holding device such that a level of the first reagent in the holding device is higher than a level of the sample when the sample is added to the holding device at least one time.
9. The sample analyzer of claim 5, wherein the sample analyzer is an electrolyte analyzer and/or the detection component is an electrolyte detection component, the detection component comprising a detection electrode, the housing device further provided with a third interface, the third interface being higher than or equal to the first interface in height on the housing device;
the sample analyzer further comprises a third power piece for injecting a second reagent in the reagent container into the accommodating device through the third interface;
the controller is further configured to:
controlling the first power part to operate so as to inject the first reagent in the reagent container into the accommodating device through the first interface, and
controlling the second power part to operate so as to discharge the first reagent in the accommodating device;
controlling the second power piece to discharge the first reagent in the accommodating device to flow through the detection assembly, so as to obtain a detection result of the first reagent;
controlling the third power part to inject a second reagent in the reagent container into the accommodating device through the third interface, and controlling the second power part to discharge the second reagent in the accommodating device to flow through the detection assembly to obtain a detection result of the second reagent, wherein the ion concentration of the second reagent is lower than that of the first reagent;
And adjusting the electrode slope of the detection component according to the detection result of the first reagent and the detection result of the second reagent.
10. The sample analyzer according to any one of claims 1 to 9, wherein a bottom wall of the accommodation chamber formed by the accommodation device is provided with a liquid outlet, the sample analyzer further comprises a liquid discharge channel penetrating through a bottom of the sample container and communicating with the liquid outlet, the first interface is provided on a side wall of the liquid discharge channel, and the second interface is provided on a side wall of the liquid discharge channel or a bottom end of the liquid discharge channel as the second interface.
11. The sample analyzer of any one of claims 1-9, wherein the sample application assembly comprises a sample needle for applying a sample to the containment device through a top opening of the containment device; the liquid discharge axis of the sample needle when the liquid is filled into the containing device is not overlapped with the projection of the center of the second interface on the horizontal plane.
12. The sample analyzer of claim 11, wherein the side wall of the housing means is formed with a flow guiding surface along which the sample flows toward the bottom of the housing means when the sample needle is introducing the sample into the housing means.
13. The sample analyzer of claim 12, wherein a lower edge of the flow guiding surface extends to a bottom of the receiving means.
14. A method for controlling a sample analyzer, comprising:
adding a sample to the holding device;
sucking part of the sample in the accommodating device from a first interface, close to the bottom, of the accommodating device;
and detecting the residual sample in the accommodating device to obtain a detection result.
15. The control method of claim 14, further comprising, prior to adding the sample to the receiving device:
air is sucked from the first interface to form an air column.
16. The control method according to claim 14, wherein the detection result obtained by detecting the remaining sample in the accommodating device includes:
and discharging the residual sample in the accommodating device from a second interface of the accommodating device to flow through a detection component of the sample analyzer for detection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210336397.6A CN116930527A (en) | 2022-03-31 | 2022-03-31 | Sample analyzer and control method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210336397.6A CN116930527A (en) | 2022-03-31 | 2022-03-31 | Sample analyzer and control method thereof |
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| CN116930527A true CN116930527A (en) | 2023-10-24 |
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| CN202210336397.6A Pending CN116930527A (en) | 2022-03-31 | 2022-03-31 | Sample analyzer and control method thereof |
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| CN (1) | CN116930527A (en) |
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