CN116930475A - 中和抗体检测方法 - Google Patents
中和抗体检测方法 Download PDFInfo
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- CN116930475A CN116930475A CN202210346390.2A CN202210346390A CN116930475A CN 116930475 A CN116930475 A CN 116930475A CN 202210346390 A CN202210346390 A CN 202210346390A CN 116930475 A CN116930475 A CN 116930475A
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
项目 | 阳性率 | 1:2 | 1:6 | 1:18 | 1:54 |
终产品制剂阳性率 | 32.7% | 32.7% | 32.7% | 32.7% | 32.7% |
Day 0阳性率 | / | 34.3% | 36.7% | / | / |
Day 28阳性率 | / | 26.3% | 33.3% | 37.3% | 38.0% |
中和抗体中和效率 | / | 23.3% | 9.26% | / | / |
项目 | 阳性率 | 1:2 | 1:6 | 1:18 | 1:54 |
终产品制剂阳性率 | 96.8% | 96.8% | 96.8% | 96.8% | 96.8% |
Day 0阳性率 | / | 97.0% | 97.1% | / | / |
Day 21阳性率 | / | 53.6% | 76.0% | 88.4% | 93.2% |
中和抗体中和效率 | / | 44.7% | 21.7% | 8.9% | / |
项目 | 阳性率 | 1:2 | 1:6 | 1:18 | 1:54 |
终产品制剂阳性率 | 96.8% | / | / | / | / |
Day 0阳性率 | / | 96.0% | 96.9% | / | / |
Day 21阳性率 | / | 93.2% | 95.4% | 96.8% | 96.9% |
中和抗体中和效率 | / | 2.9% | 1.5% | / | / |
Claims (10)
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CN202210346390.2A CN116930475A (zh) | 2022-03-31 | 2022-03-31 | 中和抗体检测方法 |
PCT/CN2023/085530 WO2023186106A1 (zh) | 2022-03-31 | 2023-03-31 | 中和抗体检测方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN202210346390.2A CN116930475A (zh) | 2022-03-31 | 2022-03-31 | 中和抗体检测方法 |
Publications (1)
Publication Number | Publication Date |
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CN116930475A true CN116930475A (zh) | 2023-10-24 |
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CN202210346390.2A Pending CN116930475A (zh) | 2022-03-31 | 2022-03-31 | 中和抗体检测方法 |
Country Status (2)
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CN (1) | CN116930475A (zh) |
WO (1) | WO2023186106A1 (zh) |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9416671D0 (en) * | 1994-08-17 | 1994-10-12 | Biocine Spa | Assay |
CN1444044A (zh) * | 2002-06-18 | 2003-09-24 | 帕弗瑞生物技术(北京)有限公司 | 以酶联免疫测定为基础的hla补体依赖性细胞毒性抗体检测方法和试剂盒 |
WO2009111572A2 (en) * | 2008-03-04 | 2009-09-11 | Le Centre Nationale De La Recherche Scientifique | Cell, method and kit for conducting an assay for neutralizing antibodies |
MX2016005686A (es) * | 2013-10-31 | 2016-08-11 | Regeneron Pharma | Ensayo de union competitiva al ligando para detectar anticuerpos neutralizantes. |
WO2017079729A1 (en) * | 2015-11-06 | 2017-05-11 | Biomarin Pharmaceutical Inc. | Cell-based assays for detection of antibodies or other factors that neutralize uptake of lysosomal enzymes |
CN111100199B (zh) * | 2018-12-29 | 2021-02-12 | 北京百普赛斯生物科技股份有限公司 | 一种荧光素标记的蛋白四聚体及其制备方法与应用 |
CN112394179B (zh) * | 2021-01-18 | 2021-04-09 | 北京百普赛斯生物科技股份有限公司 | Fmc63 car-t细胞免疫原性elisa检测试剂盒 |
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2022
- 2022-03-31 CN CN202210346390.2A patent/CN116930475A/zh active Pending
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2023
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