CN116920063A - 一种改善皮肤痤疮及色素沉积的中药组合物及其制备方法 - Google Patents
一种改善皮肤痤疮及色素沉积的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种改善皮肤痤疮及色素沉积的中药组合物,它是由下述重量配比的原料药制备而成的制剂:知母20‑30份、黄柏15‑25份、柴胡18‑22份、郁金15‑25份、桃仁10‑18份、红花12‑18份、川芎10‑20份、当归15‑25份、杜仲8‑12份、鳖甲20‑30份、覆盆子10‑20份、丹参15‑25份、荆芥15‑25份、蝉衣8‑12份、虎杖15‑25份、黄芩20‑30份,并公开其制备方法,本发明能清肺凉血,滋阴降火,兼活血化瘀,调理冲任,共同治疗痤疮,效果显著。
Description
技术领域
本发明涉及一种改善皮肤痤疮及色素沉积的中药组合物及其制备方法,属于医药领域。
背景技术
痤疮俗称“青春痘”,是青少年常见的一种毛囊皮脂腺慢性炎症性皮肤病,易反复发作,严重影响颜面美观,对青少年的心理健康和生活质量造成较大影响。***痤疮原因,主要有:1、生理因素:人体的内分泌腺激素可以保持生理处于平衡,但这些生长调节剂一般会随年龄增长而失调,这也就是为什么年纪越小,内分泌越少成为困扰我们的话题,可随着年龄增长,就需要给它更多关注。有些人的内分泌失调来自于遗传。2、营养因素:人体维持正常的生理功能,就必须有足够的、适当的营养,否则,内分泌等问题就会一一出现。3、情绪因素:心理也是导致内分泌失调的原因。我们要承受来自各个方面的压力,哪一种压力都需要打起十二分的精神来应对,难以彻底放松下来。这种紧张状态和情绪改变反射到神经***,会造成激素分泌的紊乱,即通常所说的内分泌失调。4、环境因素:严重的环境污染对女性内分泌失调罪责难逃。空气中的一些化学物质,在通过各种渠道进入人体后,经过一系列的化学反应,导致内分泌失调,使女性出现***、子宫内膜增生等诸多问题。
中医将痤疮分为3个证型,分为肺热火旺证、肠胃湿热证还有痰湿郁滞证。肺经风热证的主要症状是面部红色丘疹,有些丘疹有瘙痒、疼痛感,偶尔有脓疱伴有口渴、小便发黄,这种痤疮的治疗主要是疏风清肺,常用的方剂是枇杷清肺饮,主要成分有石膏、枇杷、连翘等。肠胃湿热证的主要症状是面部及胸背部皮肤油腻,痤疮红肿、疼痛伴有口臭、便秘,治疗以清热、利湿、解毒为主,常用的处方是茵陈蒿汤,主要成分有茵陈、栀子、大黄等。痰湿瘀滞证的痤疮主要表现是皮疹颜色暗红,以结节、囊肿和瘢痕为主,病情缠绵难治愈,治疗以除湿化痰、活血散结为主,常用的方剂是二陈汤加上桃红四物汤,主要成分有半夏、桃仁、茯苓等。其中肺热火旺证最为常见。
因此,提供一种防治皮肤痤疮及色素沉积药效明确、成本低廉的中药,成为了一个亟待解决的问题。
发明内容
本发明的目的在于提供一种改善皮肤痤疮及色素沉积的中药组合物及其制备方法。
本发明提供了一种改善皮肤痤疮及色素沉积的中药组合物,它是由下述重量配比的原料药制备而成的制剂:知母20-30份、黄柏15-25份、柴胡18-22份、郁金15-25份、桃仁10-18份、红花12-18份、川芎10-20份、当归15-25份、杜仲8-12份、鳖甲20-30份、覆盆子10-20份、丹参15-25份、荆芥15-25份、蝉衣8-12份、虎杖15-25份、黄芩20-30份。
一种改善皮肤痤疮及色素沉积的中药组合物,它是由下述重量配比的原料药制备而成的制剂:知母25份、黄柏20份、柴胡20份、郁金20份、桃仁14份、红花15份、川芎15份、当归20份、杜仲10份、鳖甲25份、覆盆子15份、丹参20份、荆芥20份、蝉衣10份、虎杖20份、黄芩25份。
一种改善皮肤痤疮及色素沉积的中药组合物,它是由下述重量配比的原料药制备而成的制剂:知母20份、黄柏25份、柴胡18份、郁金25份、桃仁10份、红花18份、川芎10份、当归25份、杜仲8份、鳖甲30份、覆盆子10份、丹参25份、荆芥15份、蝉衣12份、虎杖15份、黄芩30份。
一种改善皮肤痤疮及色素沉积的中药组合物,它是由下述重量配比的原料药制备而成的制剂:知母30份、黄柏15份、柴胡22份、郁金15份、桃仁18份、红花12份、川芎20份、当归15份、杜仲12份、鳖甲20份、覆盆子20份、丹参15份、荆芥25份、蝉衣8份、虎杖25份、黄芩20份。
所述的中药组合物,它是由各重量配比原料药的原生药粉、水或有机溶剂的提取物,加入药学上可接受的辅料或者辅助性成分制备而成的制剂。
所述的中药组合物,所述的制剂为口服制剂。
所述的中药组合物,所述的制剂为散剂、颗粒剂、胶囊剂、片剂或口服液中的一种。
所述中药组合物的制备方法,包括如下步骤:取各重量配比的原料药,直接打粉,或加入水或有机溶剂提取,再加入药学上可接受的辅料或者辅助性成分,即得。
所述的制备方法,所述加水提取包括如下步骤:a、称取各重量配比的柴胡、郁金、桃仁、红花、川芎、当归、荆芥,水蒸气蒸馏法提取挥发油,备用;b、提取挥发油后药渣再加入其他药材,加水提取,收集提取液,浓缩;c、向浓缩液中加入乙醇,静置,过滤,收集醇沉液;d、将醇沉液与挥发油混合均匀,即得。
所述的制备方法:a步骤水蒸气蒸馏法提取挥发油时间为4小时;b步骤水提条件为:加入药材6倍量水,回流提取2次,每次提取时间0.5h,将所得提取液浓缩至密度为1.20g/ml;c步骤向浓缩液中加入95%v/v乙醇水溶液,至乙醇浓度为85%v/v。
所述中药组合物在制备改善皮肤痤疮及色素沉积的药物中的用途。
所述的用途,所述的药物是改善皮肤痤疮及色素沉积的药物。
所述的用途,所述皮肤痤疮及色素沉积属于肺热火旺型。
《医宗金鉴·外科心法要诀·肺风粉刺》说:“此证由肺经血热而成。每发于面鼻,起碎疙瘩,形如黍屑,色赤肿痛,破出白粉汁。日久皆成白屑,形如黍米白屑”。以有粉刺、丘疹、脓疱、囊肿等多种损害为特征。本病多因肾阴不足、相火过旺,加之饮食不节,过食肥甘厚味和冲任不调,肺胃火热上蒸头面,血热郁滞而成。其中肺热火旺型最为常见,常常青少年期发病,皮疹以红色丘疹和粉刺为主,伴有脓疱、红色结节和疼痛,口干心烦,遗精耳鸣,多梦,大便秘结,小便黄。舌红苔黄,脉数或弦数。常规方法使用清肺凉血,滋阴降火,但并未取得良好效果。究其原因,由于痤疮久治不愈,颜面等部位皮损经年不消退,色红或暗红,如果一味清肺凉血,滋阴降火,只能清肺火,此时已经冲任失调,痰凝瘀结,需要同时疏肝活血才能达到治疗目的,故本发明采用知母、黄柏清肺凉血、滋阴降火,柴胡、郁金滋阴疏肝,知母、黄柏、柴胡、郁金共为君药;肺热火旺常伴痰凝瘀结和冲任失调,故采用桃仁、红花、川芎、当归活血化瘀,杜仲、鳖甲、覆盆子、丹参,分别补冲脉之气、冲脉之血、任脉之气、任脉之血,共同调理冲任,桃仁、红花、川芎、当归、杜仲、鳖甲、覆盆子、丹参共为臣药;痤疮常伴瘙痒,故采用荆芥、蝉衣疏风散热,透诊止痒,利咽开音,退翳明目,解痉消肿,为佐药;还因为大便秘结,采用虎杖、黄芩化湿通腑,为使药,全方知母、黄柏、柴胡、郁金、桃仁、红花、川芎、当归、杜仲、鳖甲、覆盆子、丹参、荆芥、蝉衣、虎杖、黄芩,清肺凉血,滋阴降火,兼活血化瘀,调理冲任,共同治疗痤疮,效果显著。
总之,本发明通过如下治法治则来治疗肺热火旺型皮肤痤疮及色素沉积:一、清肺凉血、滋阴降火;二:滋阴疏肝;三:活血化瘀;四:调理冲任;五:疏风散热、解痉消肿;六:化湿通腑。共同发挥作用产生效果。
具体实施方式
下面结合具体实施方式,进一步阐述本发明。应理解,这些实施例仅用于说明本发明而不用于限制本发明的范围。此外应理解,在阅读了本发明记载的内容之后,本领域技术人员可以对本发明作各种改动或修改,但这些等价形式同样落于本申请所附权利要求书所限定的范围。
本发明具体实施方式中使用的原料、设备均为已知产品,通过购买市售产品获得,均符合《中国药典》2010版一部项下的相关要求。
实施例1:
取知母25g、黄柏20g、柴胡20g、郁金20g、桃仁14g、红花15g、川芎15g、当归20g、杜仲10g、鳖甲25g、覆盆子15g、丹参20g、荆芥20g、蝉衣10g、虎杖20g、黄芩25g,制备方法为:
a、称取各重量配比的柴胡、郁金、桃仁、红花、川芎、当归、荆芥,水蒸气蒸馏法提取挥发油,时间为4小时,备用;
b、提取挥发油后药渣再加入其他药材,加入药材6倍量水,回流提取2次,每次提取时间0.5h,收集提取液,浓缩至密度为1.20g/ml;
c、向浓缩液中加入加入95%v/v乙醇水溶液,至乙醇浓度为85%v/v,静置,过滤,收集醇沉液;
d、将醇沉液与挥发油混合均匀,加辅料制备成颗粒剂,即得。
实施例2:
取知母20g、黄柏25g、柴胡18g、郁金25g、桃仁10g、红花18g、川芎10g、当归25g、杜仲8g、鳖甲30g、覆盆子10g、丹参25g、荆芥15g、蝉衣12g、虎杖15g、黄芩30g,制备方法为:
a、称取各重量配比的柴胡、郁金、桃仁、红花、川芎、当归、荆芥,水蒸气蒸馏法提取挥发油,时间为4小时,备用;
b、提取挥发油后药渣再加入其他药材,加入药材6倍量水,回流提取2次,每次提取时间0.5h,收集提取液,浓缩至密度为1.20g/ml;
c、向浓缩液中加入加入95%v/v乙醇水溶液,至乙醇浓度为85%v/v,静置,过滤,收集醇沉液;
d、将醇沉液与挥发油混合均匀,加辅料制备成片剂,即得。
实施例3:取知母30g、黄柏15g、柴胡22g、郁金15g、桃仁18g、红花12g、川芎20g、当归15g、杜仲12g、鳖甲20g、覆盆子20g、丹参15g、荆芥25g、蝉衣8g、虎杖25g、黄芩20g,制备方法为:
a、称取各重量配比的柴胡、郁金、桃仁、红花、川芎、当归、荆芥,水蒸气蒸馏法提取挥发油,时间为4小时,备用;
b、提取挥发油后药渣再加入其他药材,加入药材6倍量水,回流提取2次,每次提取时间0.5h,收集提取液,浓缩至密度为1.20g/ml;
c、向浓缩液中加入加入95%v/v乙醇水溶液,至乙醇浓度为85%v/v,静置,过滤,收集醇沉液;
d、将醇沉液与挥发油混合均匀,加辅料制备成口服液,即得。
实施例4:
取知母25g、黄柏20g、柴胡20g、郁金20g、桃仁14g、红花15g、川芎15g、当归20g、杜仲10g、鳖甲25g、覆盆子15g、丹参20g、荆芥20g、蝉衣10g、虎杖20g、黄芩25g,制备方法为:
a、称取各重量配比的柴胡、郁金、桃仁、红花、川芎、当归、荆芥,水蒸气蒸馏法提取挥发油,时间为4小时,备用;
b、提取挥发油后药渣再加入其他药材,加入药材6倍量水,回流提取2次,每次提取时间0.5h,收集提取液,浓缩至密度为1.20g/ml;
c、向浓缩液中加入加入95%v/v乙醇水溶液,至乙醇浓度为85%v/v,静置,过滤,收集醇沉液;
d、将醇沉液与挥发油混合均匀,加辅料制备成胶囊剂,即得。
实施例5:
取知母20g、黄柏25g、柴胡18g、郁金25g、桃仁10g、红花18g、川芎10g、当归25g、杜仲8g、鳖甲30g、覆盆子10g、丹参25g、荆芥15g、蝉衣12g、虎杖15g、黄芩30g,制备方法为:
a、称取各重量配比的柴胡、郁金、桃仁、红花、川芎、当归、荆芥,水蒸气蒸馏法提取挥发油,时间为4小时,备用;
b、提取挥发油后药渣再加入其他药材,加入药材6倍量水,回流提取2次,每次提取时间0.5h,收集提取液,浓缩至密度为1.20g/ml;
c、向浓缩液中加入加入95%v/v乙醇水溶液,至乙醇浓度为85%v/v,静置,过滤,收集醇沉液;
d、将醇沉液与挥发油混合均匀,加辅料制备成散剂,即得。
实施例6:
临床实验:参照中华医学美学与美容学分会皮肤美容学组寻常痤疮分级和疗效准初步制定,皮损主要为累及颜面部的散在性黑头粉刺、炎性丘疹、脓包、结节、囊肿,确诊为痤疮者。选择面部痤疮患者100例(面部散在或密集分布红色或淡红色丘疹,或红热肿痛,或有脓疮,状如粟米,有的可挤出白色油性物,或有大小不一的结节和囊肿),中医诊断为肺热火旺型,皮疹以红色丘疹和粉刺为主,伴有脓疱、红色结节和疼痛,口干心烦,遗精耳鸣,多梦,大便秘结,小便黄。舌红苔黄,脉数或弦数。
排除病例标准:半个月内曾***使用抗生素、或患者患有肝肾疾病的患者;或者处于妊娠期或者哺乳期的妇女或者依从性较差不能定期复诊的患者。
疗效标准:痊愈:皮疹消退90%以上,或仅遗留少许色素沉着,症状消失;显效:皮疹消退60%-89%,症状明显减轻;有效:皮损消退30%-59%,症状显著改善;无效:皮疹消退不足30%,或临床症状反见恶化。
治疗方法:服用本发明(实施例1)制得的颗粒剂(每日用量:知母25g、黄柏20g、柴胡20g、郁金20g、桃仁14g、红花15g、川芎15g、当归20g、杜仲10g、鳖甲25g、覆盆子15g、丹参20g、荆芥20g、蝉衣10g、虎杖20g、黄芩25g),每日分早晚两次水冲服服用。治疗疗程:四周为一疗程。治疗期间生活规律,不熬夜;忌食辛辣、油腻和腥发之物;忌烟酒,并且调节好情志,保持情绪稳定。
治疗效果:临床实验100例中痊愈56例,显效25例,有效14例,无效5例,痊愈率为56%,总有效率为95%,通过上述实验可得知,本发明制得的药物能够安全有效的治疗痤疮,具有较好的医学推广价值。
具体病例:
1.王某,男,22岁,学生,面部两颊处红肿明显,丘疹,伴疼痛略瘙痒。服用本发明(实施例1)制得的颗粒剂(每日用量:知母25g、黄柏20g、柴胡20g、郁金20g、桃仁14g、红花15g、川芎15g、当归20g、杜仲10g、鳖甲25g、覆盆子15g、丹参20g、荆芥20g、蝉衣10g、虎杖20g、黄芩25g),每日分早晚两次水冲服服用。4周后,面部青春痘红肿基本消退、疼痛、瘙痒均消失,痊愈。
2.张某,女,23岁,学生,反复发作面部青春痘有2年多的时间,红肿明显,丘疹、脓包较严重,白色脓胞,伴疼痛和瘙痒。服用本发明(实施例1)制得的颗粒剂(每日用量:知母25g、黄柏20g、柴胡20g、郁金20g、桃仁14g、红花15g、川芎15g、当归20g、杜仲10g、鳖甲25g、覆盆子15g、丹参20g、荆芥20g、蝉衣10g、虎杖20g、黄芩25g),每日分早晚两次水冲服服用。8周后,面部痤疮明显好转,白头消失,疼痛、瘙痒均消失,疗效十分显著。
尽管已经示出和描述了本发明的实施例,对于本领域的普通技术人员而言,可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型,本发明的范围由所附权利要求及其等同物限定。
Claims (10)
1.一种改善皮肤痤疮及色素沉积的中药组合物,其特征是:它是由下述重量配比的原料药制备而成的制剂:知母20-30份、黄柏15-25份、柴胡18-22份、郁金15-25份、桃仁10-18份、红花12-18份、川芎10-20份、当归15-25份、杜仲8-12份、鳖甲20-30份、覆盆子10-20份、丹参15-25份、荆芥15-25份、蝉衣8-12份、虎杖15-25份、黄芩20-30份。
2.如权利要求1所述的中药组合物,其特征是:它是由各重量配比原料药的原生药粉、水或有机溶剂的提取物,加入药学上可接受的辅料或者辅助性成分制备而成的制剂。
3.如权利要求2所述的中药组合物,其特征是:所述的制剂为口服制剂。
4.如权利要求3所述的中药组合物,其特征是:所述的制剂为散剂、颗粒剂、胶囊剂、片剂或口服液中的一种。
5.一种权利要求1~4任意一项所述中药组合物的制备方法,其特征是:包括如下步骤:取各重量配比的原料药,直接打粉,或加入水或有机溶剂提取,再加入药学上可接受的辅料或者辅助性成分,即得。
6.如权利要求5所述的制备方法,其特征是:所述加水提取包括如下步骤:a、称取各重量配比的柴胡、郁金、桃仁、红花、川芎、当归、荆芥,水蒸气蒸馏法提取挥发油,备用;b、提取挥发油后的药渣再加入其他药材,加水提取,收集提取液,浓缩;c、向浓缩液中加入乙醇,静置,过滤,收集醇沉液;d、将醇沉液与挥发油混合均匀,即得。
7.如权利要求6所述的制备方法,其特征是:a步骤水蒸气蒸馏法提取挥发油时间为4小时;b步骤水提条件为:加入药材6倍量水,回流提取2次,每次提取时间0.5h,将所得提取液浓缩至密度为1.20g/ml;c步骤向浓缩液中加入95%v/v乙醇水溶液,至乙醇浓度为85%v/v。
8.权利要求1~4任意一项所述中药组合物在制备改善皮肤痤疮及色素沉积药物中的用途。
9.如权利要求8所述的用途,其特征是:所述的药物是改善皮肤痤疮及色素沉积的药物。
10.如权利要求8所述的用途,其特征是:所述皮肤痤疮及色素沉积属于肺热火旺型。
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CN109481602A (zh) * | 2018-12-21 | 2019-03-19 | 河南大学 | 一种有效治疗痤疮的中药组合物及其制备方法 |
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