CN116874359A - Synthesis method of naphthalenone compound - Google Patents

Synthesis method of naphthalenone compound Download PDF

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CN116874359A
CN116874359A CN202310749367.2A CN202310749367A CN116874359A CN 116874359 A CN116874359 A CN 116874359A CN 202310749367 A CN202310749367 A CN 202310749367A CN 116874359 A CN116874359 A CN 116874359A
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naphthalenone
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开永平
文兆峰
鲁刚
柴宝红
范银彬
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Beijing Lambert Technology Co ltd
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Abstract

The invention discloses a synthesis method of naphthalenone compounds, and relates to the technical field of organic synthesis. According to the invention, aromatic aldehyde and the wittig reagent prepared by the method are reacted to obtain an olefin compound, and then the olefin compound is utilized to perform a reduction reaction and a ring closure reaction to prepare a naphthalenone compound. The invention has the advantages of easily obtained raw materials and mild overall reaction condition, and has no limitation on the type and position of substituent groups on aromatic rings, and the wittig reagent can be adopted for reaction to prepare the synthetic naphthalenone. The synthesis method has wide application range and is easy for industrial production.

Description

Synthesis method of naphthalenone compound
Technical Field
The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of naphthalenone compounds.
Background
The synthesis of new chemical drugs is an important component in the field of fine chemical engineering, and becomes the focus direction of development and competition in the last decade, and along with the progress of scientific technology, a plurality of new chemical drugs are continuously developed, thereby benefiting mankind. The synthesis of these chemical agents relies on the production of novel high technology content pharmaceutical intermediates, which are therefore also patented. Tetrahydronaphthalenone compounds are important intermediates, are widely used in the fields of medicines, chemical engineering, new materials and macromolecules, for example, tetrahydronaphthalenone is an important precursor for synthesizing antidepressant sertraline, 6-methoxy-1-naphthalenone is an important intermediate for synthesizing steroid medicines such as 18-methyl norethindrone, levonorgestrel and the like, 5, 8-dimethoxy-2-tetralone is a key intermediate for synthesizing antitumor medicine amrubicin, and 4- (3, 4-dichlorophenyl) -1-tetralone is an intermediate for synthesizing antidepressant sertraline, and 6-isopropyl-5-methoxy-2-tetralone is a raw material for synthesizing triptolide. Among them, halogenated tetralone is a very useful raw material because it is easily linked to various nucleophiles by halogen as a good leaving group.
Most of the existing tetralone compounds come from reduction and oxidation of naphthalene compounds, such as 5-methoxy-2-tetralone, which is obtained by reducing 1, 6-dimethoxy naphthalene in Na/EtOH. However, naphthalene derivatives with halogens cannot be prepared by reduction of halogenated naphthalene compounds under Na/EtOH reduction conditions due to side reactions such as metal reduction dehalogenation and nucleophilic substitution of halogen with sodium ethoxide. Therefore, the development of the synthesis method with wider adaptability and higher efficiency has very important significance for the development and application of tetralone and related compounds thereof.
At present, the traditional methods for synthesizing the naphthalenone are as follows:
1. and performing Friedel-crafts acylation reaction on the aromatic hydrocarbon compound and succinic anhydride, and performing reduction and ring closure reaction to obtain a naphthalenone product.
The method has the defects that Fu Kefan has stronger functional group positioning selectivity, friedel-crafts acylation position is limited, most of the obtained products are mixtures, the reduction reaction conditions relate to unit reactions such as yellow cron, claimen, noble metal hydrogenation and the like which are difficult to industrialize, and the separation difficulty is high, and the process cost is high.
2. Metal catalytic coupling reaction of bromobenzene compound and ethyl 4-iodobutyrate, and then hydrolyzing and closing ring to obtain naphthalenone;
the method needs noble metal catalyst, has high cost, and the starting material can only be halogenated aromatic hydrocarbon (bromobenzene or iodobenzene), so that the method has great limitation.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a synthesis method of a naphthalenone compound, which provides a novel wittig reagent (shown in a formula 1 or a formula 2). The wittig reagent is utilized to react with an initial raw material aromatic aldehyde, a double bond compound is formed through wittig reaction, and then a naphthalenone compound is obtained through hydrogenation reduction, ring closure or reduction, oxidation and ring closure.
The invention is realized by adopting the following technical scheme:
the synthesis process of naphthalenone compound includes the reaction of aromatic aldehyde and wittig reagent to obtain olefin compound, reduction reaction and ring closing reaction of the olefin compound to obtain naphthalenone compound, and the wittig reagent has one of the following structures:
preferably, when the wittig reagent of formula 1 is used, the naphthalenone compound is synthesized as follows:
further preferably, the synthesis method of the naphthalenone compound comprises the following steps:
(1) 3-bromopropionic acid and triphenylphosphine are reacted in acetonitrile solution to obtain a compound shown in a formula 1;
(2) Reacting aromatic aldehyde with a compound shown in a formula 1 under alkaline conditions to obtain an olefin compound;
wherein the alkali used in the reaction can be selected from potassium tert-butoxide, sodium hydride, sodium methoxide, sodium ethoxide, lithium bis (trimethylsilyl) amide (LiHMDS) and sodium bis (trimethylsilyl) amide (NaHMDS), and more preferably potassium tert-butoxide; the solvent used is selected from tetrahydrofuran THF, dioxane, methyl tert-butyl ether MTBE, dichloromethane DCM, preferably dichloromethane; the reaction temperature is controlled at-25 to 25 ℃, preferably-10 to 10 ℃.
(3) Carrying out reduction reaction on the olefin compound obtained in the step (2) to obtain aromatic carboxylic acid;
wherein the reagent used in the reduction reaction is selected from Pd/C hydrogen system, ruthenium trichloride (RuCl) 3 ) And a sodium borohydride system; the solvent used in Pd/C hydrogen system is selected from tetrahydrofuran, methanol, dioxane, ethyl acetate, preferably tetrahydrofuran;
ruthenium trichloride (RuCl) 3 ) And the solvent used in the sodium borohydride system is a mixed system of tetrahydrofuran and water, and the volume ratio of the tetrahydrofuran to the water is 4:1.
Experiments show that when the benzene butyric acid intermediate of aromatic hydrocarbon can be successfully obtained by reaction with wittig reagent, if the structure contains halogen such as bromine, chlorine, etc., the reduction reaction system of Pd/C and hydrogen can not be used for reducing double bond in the structure, and the bromine, chlorine, etc. can be reduced and dehalogenated in the reaction, the invention provides a mild reduction reaction condition, which can retain halogen and only reduce olefin double bond, namely ruthenium trichloride (RuCl) 3 ) And sodium borohydride systems.
(4) And (3) performing ring closure reaction on the aromatic carboxylic acid obtained in the step (3) to obtain a naphthalenone compound.
Wherein the ring-closing reaction system is selected from: polyphosphoric acid PPA, concentrated sulfuric acid H 2 SO 4 Methanesulfonic acid/phosphorus pentoxide.
The aromatic carboxylic acid is reacted with oxalyl chloride or thionyl chloride to obtain intermediate, and then the target compound naphthalenone is obtained under the action of Lewis acid. Wherein the Lewis acid is preferably: anhydrous aluminum trichloride or anhydrous stannous chloride.
When the wittig reagent shown in the formula 1 is adopted, the synthetic route of the naphthalenone compound is as follows:
further preferably, the synthesis method of the naphthalenone compound comprises the following steps:
s1, reacting 3-bromo-1-propanol with tert-butyldimethyl chlorosilane under alkaline conditions;
the solvent used in the reaction is selected from dichloromethane, methyl tertiary butyl ether, tetrahydrofuran and the like, preferably dichloromethane; the base used is selected from imidazole, triethylamine, N-diisopropylethylamine, preferably imidazole.
S2, carrying out reflux reaction on the reaction product of the step S1 and triphenylphosphine in a benzene solvent to obtain a compound shown in a formula 2;
s3, reacting aromatic aldehyde with the compound shown in the formula 2 under alkaline conditions to obtain an olefin compound;
the solvent used in this reaction is selected from: dioxane, tetrahydrofuran, N-dimethylformamide, preferably tetrahydrofuran; the base is selected from potassium tert-butoxide, sodium hydride, sodium methoxide, sodium ethoxide, lithium bis (trimethylsilyl) amide (LiHMDS), sodium bis (trimethylsilyl) amide (NaHMDS), etc., preferably sodium hydride.
S4, carrying out desilication reaction on the olefin compound and tetrabutylammonium fluoride;
s5, carrying out reduction reaction on the desilicated product;
the reagent used in the reduction reaction is selected from Pd/C hydrogen system, ruthenium trichloride (RuCl) 3 ) And a sodium borohydride system; the Pd/C hydrogen system solvent is selected from the group consisting of tetrahydrochyseneFuran, methanol, dioxane, ethyl acetate, preferably tetrahydrofuran;
experiments show that when the benzene butyric acid intermediate of aromatic hydrocarbon can be successfully obtained by reacting with wittig reagent, if the structure contains halogen such as bromine, chlorine, etc., the reduction reaction system of Pd/C and hydrogen can not be adopted to reduce double bonds in the structure, and bromine, chlorine, etc. can be reduced and dehalogenated in the reaction, the invention provides a mild reduction reaction condition, which can keep halogen and reduce only olefin double bonds, namely ruthenium trichloride (RuCl 3) and sodium borohydride system, and the solvent is a mixed system of tetrahydrofuran and water, and the preferable ratio is 4:1.
S6, carrying out oxidation reaction on the reduced product to obtain aromatic carboxylic acid;
the oxidation reaction system is selected from Jones reagent, potassium permanganate and Tempo/NaClO 2 The system is preferably Tempo/NaClO 2 A system.
S7, carrying out ring closure reaction on the aromatic carboxylic acid to obtain the naphthalenone compound. Refer to the step (4).
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a synthesis method of a naphthalenone compound, which has the advantages of easily available raw materials, mild overall reaction conditions and no limitation on the type and position of substituent groups on aromatic rings, and can be used for preparing the naphthalenone compound by adopting the wittig reagent for reaction. The synthesis method has wide application range and is easy for industrial production.
Drawings
FIG. 1 is a drawing of a naphthalenone of formula 13H 1 -NMR charts;
FIG. 2 is a drawing of a naphthalenone of formula 17H 1 -NMR charts;
FIG. 3 is a drawing of a naphthalenone of formula 21H 1 -NMR charts;
FIG. 4 is a drawing of H of a naphthalenone of formula 33 1 -NMR charts;
FIG. 5 is a drawing of a naphthalenone of formula 38H 1 -NMR charts;
FIG. 6 is a naphthalene 39H of ketones 1 -NMR charts;
FIG. 7 is a drawing of a naphthalenone of formula 40H 1 -NMR charts;
FIG. 8 is a drawing of a naphthalenone of formula 41H 1 -NMR charts;
FIG. 9 is a drawing of a naphthalenone of formula 42H 1 -NMR charts;
FIG. 10 is a drawing of H of a naphthalenone of formula 43 1 -NMR charts;
FIG. 11 is a drawing of a naphthalenone of formula 44H 1 -NMR charts;
FIG. 12 is a drawing of a naphthalenone of formula 46H 1 -NMR charts;
FIG. 13 is a drawing of a naphthalenone of formula 47H 1 -NMR chart.
Detailed Description
The invention will be further illustrated with reference to specific examples.
Example 1
A synthesis method of a wittig (formula 1) reagent comprises the following specific steps:
5kg of 3-bromopropionic acid and 8.99kg of triphenylphosphine are dissolved in 50L of acetonitrile, reflux reaction is carried out for 10 hours at the temperature of 85 ℃, after detection reaction is finished, the solution is concentrated under reduced pressure, 50L of petroleum ether is added into the reaction solution, solids are separated out and filtered, the solids are respectively stirred and washed for 2 times by 25L of petroleum ether, and 11.6kg of white-like solid compound of the formula 1 is obtained after drying, and the yield is 85.5%.
Example 2
A synthesis method of a wittig (formula 2) reagent comprises the following specific steps:
(1) In a washed and dried reaction bottle, 139g of 3-bromo-1-propanol and 102g of imidazole are dissolved in 1.4L of dichloromethane, under the protection of nitrogen, 150.7g of tert-butyldimethylsilyl chloride TBSCl is slowly added into the reaction liquid under the protection of nitrogen, after the addition is finished, the reaction liquid is stirred for 3 hours at room temperature, 1.4L of methyl tert-butyl ether and 1.4L of water are added into the reaction liquid for quenching reaction after the detection reaction is finished, layering, an organic phase is washed with 1L of water, 1L of saturated salt water, anhydrous sodium sulfate is dried overnight, and 240.5g of a compound of a formula 7 is obtained through concentration, and the yield is 95.1%.
(2) 25.3g of the compound of formula 7 and 26.2g of triphenylphosphine are dissolved in 500mL of benzene, the mixture is heated and refluxed for 6 to 8 hours, and after the reaction is completed, the mixture is concentrated under reduced pressure. 500mL of petroleum ether was added, stirred and filtered, and the solid was stirred with 500mL of petroleum ether 2 times to give 44.3g of the compound of formula 2 in 86.0% yield.
Example 3
A synthetic method of naphthalenone compounds comprises the following specific steps:
(1) In a 20L reaction bottle, 250g of m-bromobenzaldehyde and 673g of wittig reagent shown in formula 1 are dissolved in 8.0L of dichloromethane solution, the temperature is reduced to 0 ℃ under the protection of nitrogen, 379g of potassium tert-butoxide is slowly added into the reaction solution in batches, the reaction temperature is controlled below 0 ℃, the reaction solution is heated to room temperature after the addition, stirring is continued for 1.5h, and the reaction is detected to be completed. The reaction solution was quenched with 8.0L of water, stirred for 2 hours, adjusted to ph=14 with 1N aqueous sodium hydroxide solution, separated into layers, and the aqueous phase was extracted 2 times with 4L of dichloromethane, respectively. The aqueous phase was adjusted to ph=2 with 10% aqueous phosphoric acid solution, extracted 2 times with 5L methyl tert-butyl ether, the organic phases were combined, the organic phases were washed with 2L saturated brine, dried over anhydrous sodium sulfate, and concentrated to give 380g of the crude compound of formula 11, which was used directly in the next reaction.
(2) In a 5L three-necked flask, 380g of the compound of formula 11 obtained in the above reaction (1) was dissolved in a mixed solution of 2L tetrahydrofuran and 500mL of water, 25g of ruthenium trichloride was added, the reaction temperature was controlled at 15 ℃, 102.7g of sodium borohydride was added to the reaction solution, after the completion of the detection reaction, 2L of water quenching reaction was added, stirring was carried out for 2 to 3 hours, 2L of methyl tert-butyl ether was added, stirring was carried out for 1 hour, and the mixture was layered. The aqueous phase was adjusted to ph=2 with 10% strength by mass aqueous phosphoric acid and extracted 2 times with 2L of ethyl acetate, respectively. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 400g of the compound of formula 12, which was used directly in the next reaction.
(3) 400g of the above-described materials were charged into a dry reaction flask12 compound and 5KG polyphosphoric acid, heating to 100 ℃, reacting for 3 hours, pouring the reaction solution into ice water for quenching after detecting the completion of the reaction, adding 2.5L of ethyl acetate, stirring for 1 hour, layering the reaction solution, and extracting the water phase twice with 1.25L of ethyl acetate respectively. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give crude product, which was chromatographed on a silica gel column to give 238.9 g of the compound of formula 13, with a total yield of 78.6% in 3 steps. The chemical purity of the compound of formula 13 is 98.6%, H 1 -NMR(400MHz,CDCl 3 )δ:7.877-7.899(m,1H)7.436-7.457(m,2H)2.934-2.964(m,2H)2.638-2.671(m,2H)2.111-2.174(m,2H)。
Example 4
A synthetic method of naphthalenone compounds comprises the following specific steps:
(1) In a 5L dry reaction bottle, 50g of m-methoxybenzaldehyde and 183.1g of wittig reagent shown in formula 1 are dissolved in 2L of dichloromethane solution, the temperature is reduced to 0 ℃ under the protection of nitrogen, 102.9g of potassium tert-butoxide is slowly added into the reaction solution in batches, the reaction temperature is controlled below 0 ℃, the reaction solution is heated to room temperature after the addition is finished, stirring is continued for 2 hours, and the reaction is detected to be finished. The reaction was quenched with 2L of water, ph=14 adjusted with 1N aqueous sodium hydroxide, the layers separated and the aqueous phase extracted 2 more times with 1L of dichloromethane, respectively. The aqueous phase was adjusted to ph=2 with 10% strength by mass phosphoric acid aqueous solution, 1L of methyl tert-butyl ether was added, and stirred for 1 hour, followed by separation. The aqueous phase was extracted 2 more times with 500mL of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated to give 82.0g of the crude compound of formula 14, which was used directly in the next reaction.
(2) 82.0g of the compound of formula 14, 8.2g of Pd on charcoal and 500ml of tetrahydrofuran were added to a reaction flask, heated to 50℃and hydrogenated for 5 hours, and the completion of the reaction was detected. The reaction solution was filtered, and the filtrate was concentrated to give 80.0g of the compound of formula 15 in 95.1% yield.
(3) Into a 2L dry reaction flask were charged 80.0g of the compound of formula 15 and 1000g of polyphosphoric acid, heated to 90℃and stirred for 2.5 hours to detect completion of the reaction. The reaction solution was poured into 1L of ice water,methyl tert-butyl ether 1L was added, stirred for 1h, the layers were separated, the aqueous phase was extracted 2 times with 500mL of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give crude product, and column chromatography gave 38.0g (off-white solid, purity 98.5%, yield 58.7%) of the compound of formula 16 and 7.3g (oily liquid, purity 98.2%, yield 11.3%) of the compound of formula 17. Compound H of formula 16 1 -NMR(400MHz,CDCl 3 ) Delta 7.99-8.01 (d, 1H) 6.80-6.83 (m, 1) 6.69-6.70 (d, 1H) 3.84 (s, 3H) 2.90-2.93 (m, 2H) 2.58-2.60 (m, 2H) 2.07-2.14 (m, 2H). Compound H of formula 17 1 -NMR(400MHz,CDCl 3 )δ:7.358-7.398(m,1H)6.814-6.846(m,2H)3.854-3.902(s,3H)2.903-2.933(m,2H)2.614-2.647(m,2H)2.202-2.089(m,2H)。
Example 5
A synthetic method of naphthalenone compounds comprises the following specific steps:
(1) In a 5L dry reaction bottle, 40g of m-chlorobenzaldehyde and 144.3g of wittig reagent shown in formula 1 are dissolved in 1.8L of dichloromethane solution, the temperature is reduced to 0 ℃ under the protection of nitrogen, 78.9g of potassium tert-butoxide is slowly added into the reaction solution in batches, the reaction temperature is controlled below 0 ℃, the reaction solution is heated to room temperature after the addition is finished, stirring is continued for 2 hours, and the reaction is detected to be finished. The reaction was quenched by addition of 1.8L water, ph=14 with 1N aqueous sodium hydroxide, the layers separated and the aqueous phase extracted twice more with 900ml dichloromethane. The aqueous phase was adjusted to ph=2 with 10% aqueous phosphoric acid, 500ml of methyl tert-butyl ether was added and stirred for 1 hour, the layers were separated, the aqueous phase was extracted twice more with 250ml of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated to give 51.9g of crude compound of formula 18, which was directly used in the next reaction.
(2) In a 3L three-necked flask, 51.9g of the compound of formula 18 obtained in the above reaction was dissolved in a mixed solution of 400mL of tetrahydrofuran and 100mL of water, 5.2g of ruthenium trichloride was added, the reaction temperature was controlled at 10 ℃, 20.1g of sodium borohydride was added to the reaction solution, after completion of the detection reaction, 400mL of water was added for quenching reaction, 400mL of methyl tert-butyl ether was added and stirring was carried out for 1 hour, and the mixture was layered. The aqueous phase was adjusted to ph=2 with 10% strength by mass aqueous phosphoric acid, extracted 2 times with 400ml of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 52.5g of crude compound of formula 19, which was used directly in the next reaction.
(3) In a cleaned and dried reaction flask, 52.5g of the compound of formula 19 was dissolved in 525mL of methylene chloride under the protection of nitrogen, 0.1mL of LN, N-dimethylformamide was added thereto, 67.3g of oxalyl chloride was slowly added dropwise thereto, and the reaction was stirred at room temperature for 2 hours, to thereby complete the reaction. The reaction solution is directly concentrated to obtain the compound of the formula 20, the compound of the formula 20 is dissolved in 550mL of dichloromethane, the temperature is controlled to 15 ℃, 52.9g of anhydrous aluminum trichloride is added in batches, the mixture is stirred for 1.5h at room temperature after the addition is finished, and the completion of the reaction is detected. The reaction solution was poured into 1L of ice water, stirred for 2 hours, and separated. The aqueous phase was extracted twice with 500ml of dichloromethane, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give crude product. Petroleum ether/ethyl acetate crystallization yields 38.7g of the compound of formula 21, which has a total yield of 75.3% and a purity of 98.6% in three steps. H 1 -NMR(400MHz,CDCl 3 )δ:7.886-7.907(d,1H)7.188-7.213(m,2H)2.856-2.885(m,2H)2.561-2.592m,2H)2.037-2.096(m,2H)。
Example 6
A synthetic method of naphthalenone compounds comprises the following specific steps:
(1) Under the protection of nitrogen, 236.3g of wittig reagent shown in formula 2 and 1.2L of tetrahydrofuran are added into a 5L dry three-port bottle, the temperature is controlled to be 10 ℃, 20.0g of sodium hydride is added, stirring is continued for 30min, 50.0g of o-methylbenzaldehyde tetrahydrofuran solution (50 g of o-methylbenzaldehyde is dissolved in 250mL of tetrahydrofuran) is dripped into the reaction bottle, the reaction temperature is controlled to be 10 ℃, stirring is carried out for 1.5 hours, and the reaction is detected to be completed. Adding 1.0L of 10% phosphoric acid water solution, quenching reaction, stirring for 30min, and layering. The aqueous phase was extracted twice with 500mL of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 220g of crude compound of formula 22, which was used in the next reaction without further purification.
(2) In a 5L dry reaction flask, 220g of the compound of formula 22 was dissolved in 1100mL of tetrahydrofuran, 196.9g of tetrabutylammonium fluoride trihydrate was added, heated to 50℃and stirred for 4 hours to detect completion of the reaction. 500mL of water was added to quench the reaction, stirred for 30min, 1100mL of methyl tert-butyl ether was added, and the mixture was stirred for delamination. The aqueous phase was re-extracted twice with 550mL of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 105g of crude product, which was chromatographed on silica gel to give 50.5g of compound of formula 23, 96.8% chemical purity, and the total yield of the two combined steps was 74.8%.
(3) 50.5g of the compound of formula 23 and 5.1g of Pd/C on palladium on charcoal were dissolved in 250mL of tetrahydrofuran, heated to 50℃and hydrogenated for 5 hours, and the reaction was checked for completion. The reaction solution was filtered and the filtrate was concentrated to give 49.2g of the compound of formula 24 with an HPLC purity of 96.5% and a yield of 96.3%.
(4) 93.6g of sodium dihydrogen phosphate and 214.8.0g of disodium hydrogen phosphate were dissolved in 895.5mL of water to prepare a phosphate buffer solution; 49.2g of the compound of formula 24, 492mL of acetonitrile and the phosphate buffer solution prepared above are added into a three-necked flask, 3.4g of 2, 6-tetramethylpiperidine oxide Tempo is added, the mixture is stirred at room temperature for 10min, 84.6g of sodium chlorite saturated aqueous solution and 85mL of sodium hypochlorite aqueous solution with mass concentration of 1% are slowly added dropwise into the reaction solution, the reaction temperature is controlled to be not higher than 40 ℃, the detection reaction is completed, 1000mL of ethyl acetate is added, the saturated aqueous solution of sodium thiosulfate is added under stirring to quench the reaction, the pH=4 is regulated by the 10% phosphoric acid aqueous solution with mass concentration, the mixture is layered, and the organic phase is concentrated to obtain a crude product. The crude product is dissolved in 500mL of methyl tertiary butyl ether, the pH=12 is regulated by 10% sodium hydroxide aqueous solution with mass concentration, the layers are separated, the aqueous phase is respectively extracted and washed twice by 250mL of methyl tertiary butyl ether, the pH=2 is regulated by 10% phosphoric acid aqueous solution with mass concentration, 500mL of methyl tertiary butyl ether is added, the layers are stirred and separated, the aqueous phase is respectively extracted twice by 250mL of methyl tertiary butyl ether, the organic phases are combined, the anhydrous sodium sulfate is dried and concentrated to obtain 45.6g of compound with the formula 25, the white solid is similar, the chemical purity HPLC=97.1%, and the yield is 85.4%.
(5) In a clean and oven-dried reaction flask, 45.6g of the compound of formula 25 was dissolved in 456mL of methylene chloride under nitrogen protection, 0.1mL of LN, N-dimethylformamide was added thereto, and the mixture was slowly dropped65.1g of oxalyl chloride was stirred at room temperature for 2h and the reaction was checked to be complete. The reaction solution is concentrated to obtain the compound of the formula 26, the compound of the formula 26 is dissolved in 600mL of dichloromethane, 51.1g of anhydrous aluminum trichloride is added in batches at the temperature of 0-25 ℃, and after the addition is finished, the mixture is stirred for 4 hours at room temperature, and the completion of the reaction is detected. The reaction solution was poured into 600mL of ice water, stirred for 2h, and the layers were separated. Extracting the water phase with 300mL dichloromethane twice, mixing the organic phases, drying with anhydrous sodium sulfate, concentrating to obtain crude product, crystallizing with petroleum ether ethyl acetate to obtain 34.9g of compound of formula 27, yield 85.1%, chemical purity 98.5%, H 1 -NMR(400MHz,CDCl 3 )δ:7.93-7.96(m,1H)7.36-7.38(d,1H)7.21-7.28(m,1H)2.87-2.90(m,2H)2.64-2.67(m,2H)2.34(s,1H)2.14-2.21(m,2H)。
Example 7
A synthetic method of naphthalenone compounds comprises the following specific steps:
(1) Under the protection of nitrogen, 16.9g of sodium hydride is dissolved in 500mL of tetrahydrofuran in a 2L dry three-mouth bottle, 199.5g of compound of formula 2 is slowly added into the solution, the reaction temperature is controlled between 0 ℃ and 25 ℃, stirring is continued for 30min after the addition is finished, 50g of tetrahydrofuran solution of 2, 3-difluorobenzaldehyde (50 g of 2, 3-difluorobenzaldehyde is dissolved in 250mL of tetrahydrofuran) is dripped into the reaction bottle, the reaction temperature is controlled between 40 ℃, stirring is carried out for 2 to 3h, and the reaction is detected. 500mL of 10% phosphoric acid aqueous solution by mass concentration is added to quench the reaction, 1000mL of methyl tert-butyl ether is added, and the mixture is stirred for 30min and layered. The aqueous phase was extracted twice more with 500mL of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate, and concentrated 205g of crude compound of formula 28 was used in the next reaction without further purification.
(2) In a 3L dry reaction flask, 205g of the compound of formula 28 was dissolved in 1000mL of tetrahydrofuran, 166.4g of tetrabutylammonium fluoride trihydrate was added, heated to 50℃and stirred for 2 hours to detect completion of the reaction. Adding 500mL of water for quenching reaction, adding 1000mL of methyl tertiary butyl ether, stirring for 30min, layering, extracting water phase twice with 500mL of methyl tertiary butyl ether respectively, combining organic phases, drying and concentrating with anhydrous sodium sulfate to obtain 108g of crude product, obtaining 50.2g of pure compound of formula 29 by silica gel column chromatography, having the purity of 97.3%, and combining the total yield of the two steps of reaction of 77.5%.
(3) 50.2g of the compound of formula 29 and 5.0g of Pd/C on palladium on charcoal were dissolved in 251mL of methanol, heated to 50℃and hydrogenated for 6 hours, and the reaction was checked for completion. The reaction solution was filtered, and the filtrate was concentrated to give 49.6g of the compound of formula 30, 97.5% in liquid phase purity and 97.8% in yield.
(4) 83.2g of sodium dihydrogen phosphate and 190.9g of disodium hydrogen phosphate were dissolved in 796mL of water to prepare a phosphate buffer solution; 49.6g of the compound of formula 30, 496mL of acetonitrile and the phosphate buffer prepared above were added to a three-necked flask, 3.5g of 2, 6-tetramethylpiperidine oxide Tempo was added, and after stirring at room temperature for 10 minutes, 75.2g of a saturated aqueous solution of sodium chlorite and 75.2mL of an aqueous solution of sodium hypochlorite with a mass concentration of 1% were slowly added dropwise to the reaction solution, the reaction temperature was controlled to not exceed 40 ℃, and the completion of the reaction was detected. 1000mL of ethyl acetate was added, the reaction was quenched by adding saturated aqueous solution of sodium thiosulfate with stirring, and the ph=4 was adjusted with 10% by mass of aqueous phosphoric acid solution, and the layers were separated. The organic phase is concentrated to obtain a crude product, the crude product is dissolved in 250mL of methyl tertiary butyl ether, the pH value is regulated to be 12 by using a 10% sodium hydroxide aqueous solution, the layers are separated, the aqueous phase is respectively washed for 2 times by using 125 mM TBE, the pH value is regulated to be 2 by using a 10% phosphoric acid aqueous solution, 500mL of methyl tertiary butyl ether is added, and the layers are stirred and separated. The aqueous phase was extracted 2 times with 250mL of methyl tert-butyl ether, and the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 45.9g of the compound of formula 31, 97.5% chemical purity, 86.1% yield.
(5) In a cleaned and dried reaction flask, 45.9g of the compound of formula 31 was dissolved in 460mL of methylene chloride under the protection of nitrogen, 0.1mL of LN, N-dimethylformamide was added thereto, 58.3g of oxalyl chloride was slowly added dropwise thereto, and the reaction was stirred at room temperature for 4 hours, to thereby complete the reaction. The reaction solution is directly concentrated to obtain the compound of the formula 32. The compound of formula 32 was dissolved in 500mL of methylene chloride, the temperature was controlled at 5℃and 45.8g of anhydrous aluminum trichloride was added in portions, and after the addition was completed, the mixture was stirred at room temperature for 2 hours, and the completion of the reaction was detected. The reaction solution was poured into 500mL of ice water, stirred for 1h, and separated. The aqueous phase was extracted 2 more times with 250mL of dichloromethane, the organic phases were combined, dried over anhydrous sodium sulfate,concentrating to obtain crude product, subjecting to silica gel column chromatography to obtain compound of formula 33 31.1g, yield 74.6%, chemical purity 98.5%, and H 1 -NMR(400MHz,CDCl 3 )δ:7.822-7.856(m,1H)7.071-7.136(d,1H)2.971-3.001(m,2H)2.631-2.663(m,2H)
2.134-2.197(m,2H)。
Example 8
A synthetic method of naphthalenone compounds comprises the following specific steps:
(1) Under the protection of nitrogen, 13.0g of sodium hydride is dissolved in 500mL of tetrahydrofuran in a 2L dry three-mouth bottle, the temperature is controlled at 0 ℃, 153.0g of the compound of formula 2 is slowly added into the solution, the reaction temperature is controlled at 0 ℃, and stirring is continued for 30min after the addition is finished. 47g of o-trifluoromethylbenzaldehyde in tetrahydrofuran (47 g of o-trifluoromethylbenzaldehyde is dissolved in 235mL of tetrahydrofuran) was dropped into the above reaction flask, the reaction temperature was controlled below 40℃and stirred for 2 to 3 hours, and the completion of the reaction was detected. The reaction mixture was quenched by adding 500mL of 10% strength by mass aqueous phosphoric acid, 1000mL of methyl tert-butyl ether was added, and the mixture was stirred for 30min, followed by delamination. The aqueous phase was extracted 2 more times with 500mL of methyl tert-butyl ether, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 185g of crude compound of formula 34, which was used in the next reaction without further purification.
(2) In a 2L dry reaction flask, 185g of the compound of formula 34 was dissolved in 925mL of tetrahydrofuran, 127.6g of tetrabutylammonium fluoride trihydrate was added, the mixture was heated to 50℃and stirred for 3 to 4 hours to detect the completion of the reaction. The reaction mixture was quenched with 500mL of water, 1000mL of methyl tert-butyl ether was added and the layers were separated with stirring, and the aqueous phase was extracted 2 more times with 500mL of methyl tert-butyl ether, respectively. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated to give 105g of crude product, which was chromatographed on silica gel to give 47.0g of compound of formula 35, 97.5% purity, combined with a total yield of 80.6% in the two steps.
(3) 47.0g of the compound of formula 35 and 4.7g of Pd/C on palladium carbon were dissolved in 235mL of methanol, heated to 50℃and hydrogenated for 6 hours, and the completion of the reaction was detected. The reaction solution was filtered, and the filtrate was concentrated to give 45.1g of the compound of formula 36 in 95.1% yield.
(4) A phosphate buffer solution was prepared by dissolving 64.5g of sodium dihydrogen phosphate and 148.1g of disodium hydrogen phosphate in 618mL of water. 45.1g of the compound of formula 36, 451mL of acetonitrile and the phosphate buffer prepared above were added to a three-necked flask, 3.2g of 2, 6-tetramethylpiperidine oxide Tempo was added, and after stirring at room temperature for 30 minutes, 58.3g of a saturated aqueous solution of sodium chlorite and 58.3mL of an aqueous solution of sodium hypochlorite having a mass concentration of 1% were slowly added dropwise to the reaction solution, the reaction temperature was controlled to not exceed 40℃and the completion of the reaction was detected. 500mL of ethyl acetate is added, saturated aqueous solution of sodium thiosulfate is added for quenching reaction, pH=4 is adjusted by using 10% phosphoric acid aqueous solution with mass concentration, layers are separated, and the organic phase is concentrated to obtain crude products. The crude product is dissolved in 500mL of methyl tertiary butyl ether, pH=12 is regulated by 10% sodium hydroxide aqueous solution with mass concentration, layering is carried out, water phases are respectively washed by 250 mM TBE for 2 times, pH=2 is regulated by 10% phosphoric acid aqueous solution with mass concentration, 500mL of methyl tertiary butyl ether is added, stirring layering is carried out, 250mL of methyl tertiary butyl ether is respectively used for extracting water phases for two times, organic phases are combined, anhydrous sodium sulfate is dried and concentrated to obtain 41.1g of compound with the formula 37, the chemical purity HPLC=97.6%, and the yield is 85.6%.
(5) And (3) adding 205.5mL of methanesulfonic acid and 50.3g of phosphorus pentoxide into a cleaned and dried reaction bottle under the protection of nitrogen, heating to 70 ℃, stirring for 30min, adding 41.1g of a compound of formula 37 in batches, controlling the reaction temperature to 70 ℃, continuing stirring for 4h after the addition is finished, and detecting the completion of the reaction. 1000mL of ice water was added to quench the reaction, 1000mL of methyl tert-butyl ether was added and stirred for 1 hour, and the layers were separated. Extracting the water phase with 500mL methyl tert-butyl ether for 2 times respectively, mixing the organic phases, drying with anhydrous sodium sulfate, concentrating to obtain 65g of crude compound of formula 38, and subjecting to silica gel column chromatography to obtain 35.6g of pure product with yield of 80.4%, purity HPLC=98.5% and H 1 -NMR(400MHz,CDCl 3 )δ:8.277-8.296(d,1H)7.839-7.859(d,1H)7.425-7.464(m,1H)3.14-3.178(m,2H)2.707-2.740(m,2H)2.168-2.232(m,2H)。
Example 9
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total synthesis yield of the compound of formula 39 is 65.5%, and the total synthesis yield of the compound of formula 40 is 10.5%. The chemical purity of the compound of formula 39 is 98.3%, H 1 -NMR(400MHz,CDCl 3 )δ:7.955-7.935(d,1H)
7.068-7.132(m,2H)2.913-2.943(m,2H)2.622-2.654(m,2H)2.385(s,3H)
2.095-2.158 (m, 2H); chemical purity of the compound of formula 40 is 98.4%, H 1 -NMR(400MHz,CDCl 3 )δ:7.284-7.347(m,1H)7.103-7.134(m,2H)2.965-2.995(m,2H)2.655-2.688(m,5H)
2.074-2.138(m,2H)。
Example 10
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total reaction yield of the compound of formula 41 is 74.3%, the chemical purity is 98.5%, H 1 -NMR(400MHz,CDCl 3 )δ:8.140-8.160(d,1H)7.553-7.579(m,2H)3.037-3.067(m,2H)2.707-2.740(m,2H)
2.169-2.232(m,2H)。
EXAMPLE 11
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total reaction yield of the compound of formula 42 is 73.8%, the chemical purity is 98.8%, H 1 -NMR(400MHz,CDCl 3 )δ:8.058-8.095(m,1H)6.933-7.025(m,2H)2.961-2.992(m,2H)2.645-2.678(m,2H)2.127-2.190(m,2H)。
Example 12
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total reaction yield of the compound shown in the formula 43 is 68.8%, the chemical purity is 98.6%, and H 1 -NMR(400MHz,CDCl 3 )δ:8.250-8.268(d,1H)7.020-7.042(d,1H)2.925-2.955(m,2H)2.645-2.678(m,2H)2.130-2.194(m,2H)。
Example 13
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total yield of the synthesis reaction of the compound of the formula 44 is 72.3 percent, the chemical purity is 98.3 percent, and H 1 -NMR(400MHz,CDCl 3 )δ:7.695-7.728(m,1H)6.921-6.970(m,1H)3.012-3.043(m,2H)2.663-2.696(m,2H)2.142-2.206(m,2H)。
Example 14
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total reaction yield of the compound of formula 45 is 65.6%, the chemical purity is 98.1%, H 1 -NMR(400MHz,CDCl 3 )δ:8.17(s,1H)7.14(s,1H)2.86-2.90(m,2H)2.61-2.65(m,2H)2.08-2.17(m,2H)。
Example 14
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total synthetic yield of the compound of formula 46 is 75.2%, the chemical purity is 98.1%, H 1 -NMR(400MHz,CDCl 3 )δ:7.993-8.015(d,1H)6.788-6.816(m,1H)6.689-6.694(d,1H)4.622-4.683(m,1H)2.904-2.934(m,2H)2.594-2.627(m,2H)2.088-2.152(m,2H)。
Example 15
A synthetic method of naphthalenone compounds comprises the following specific steps:
the total synthetic yield of the compound of formula 47 is 73.8%, the chemical purity is 98.6%, H 1 -NMR(400MHz,CDCl 3 )δ:7.842-7.855(d,1H)7.220-7.310(m,2H)2.957-2.977(m,2H)2.663-2.685(m,2H)2.146-2.189(m,2H)。
It should be noted that the above-mentioned embodiments are only a few specific embodiments of the present invention, and it is obvious that the present invention is not limited to the above embodiments, but other modifications are possible. All modifications directly or indirectly derived from the disclosure of the present invention will be considered to be within the scope of the present invention.

Claims (3)

1. A synthesis method of a naphthalenone compound is characterized in that aromatic aldehyde and a wittig reagent are reacted to obtain an olefin compound, then the olefin compound is utilized to carry out reduction reaction and ring closure reaction to prepare the naphthalenone compound, and the wittig reagent has the following structure:
2. the method for synthesizing the naphthalenone compound according to claim 1, wherein the synthetic route is as follows:
3. the method for synthesizing the naphthalenone compound according to claim 2, wherein the method for synthesizing comprises the following steps:
(1) Reacting 3-bromopropionic acid with triphenylphosphine to obtain a compound shown in a formula 1;
(2) Reacting aromatic aldehyde with a compound shown in a formula 1 under alkaline conditions to obtain an olefin compound;
(3) Carrying out reduction reaction on the olefin compound obtained in the step (2) to obtain aromatic carboxylic acid;
(4) And (3) performing ring closure reaction on the aromatic carboxylic acid obtained in the step (3) to obtain a naphthalenone compound.
CN202310749367.2A 2023-06-25 2023-06-25 Synthesis method of naphthalenone compound Pending CN116874359A (en)

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