CN116850114B - Composition for relieving and repairing and cream for relieving and repairing - Google Patents
Composition for relieving and repairing and cream for relieving and repairing Download PDFInfo
- Publication number
- CN116850114B CN116850114B CN202311056344.XA CN202311056344A CN116850114B CN 116850114 B CN116850114 B CN 116850114B CN 202311056344 A CN202311056344 A CN 202311056344A CN 116850114 B CN116850114 B CN 116850114B
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- Prior art keywords
- soothing
- skin
- repairing
- soothing repair
- repair composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HTJNEBVCZXHBNJ-XCTPRCOBSA-H trimagnesium;(2r)-2-[(1s)-1,2-dihydroxyethyl]-3,4-dihydroxy-2h-furan-5-one;diphosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.OC[C@H](O)[C@H]1OC(=O)C(O)=C1O HTJNEBVCZXHBNJ-XCTPRCOBSA-H 0.000 claims abstract description 19
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Classifications
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
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Abstract
The invention relates to the technical field of cosmetics, and particularly discloses a soothing and repairing composition, a soothing and repairing emulsion and a preparation method thereof. A soothing repair composition comprising the following components: 3% -8% of magnesium ascorbyl phosphate, 1% -5% of coastal cress callus culture filtrate, 1% -5% of roof growing grass extract, 1% -5% of ruscus aculeatus root extract and the balance of solvent. A soothing and repairing emulsion comprises humectant, thickener, chelating agent, emulsifier, emollient, p-hydroxyacetophenone, hexanediol, soothing and repairing composition, and water. A preparation method of the soothing and repairing emulsion comprises mixing the above components to obtain the soothing and repairing emulsion. The application has the effects of repairing the skin barrier of sensitive skin and improving the tolerance of sensitive skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a soothing and repairing composition, a soothing and repairing emulsion and a preparation method thereof.
Background
With the increasing level of living, many consumers are increasingly demanding their own external image, and these consumers are being wary of trying a wide variety of skin care methods in order to have better skin. Especially, some consumers have extremely high pursuit of beauty, and after blind use of sebum hormone or acid brushing products on the face, the skin becomes extremely fragile, namely sensitive skin which is often called as skin care product with little irritation, temperature change or environmental change, and various allergic symptoms such as redness, peeling, tightening, itching and the like are extremely easy to occur. In view of the above, a number of skin care products are currently on the market which are claimed to be suitable for sensitive skin. Most of skin care components used by the skin care products are mild and non-irritating, and are suitable for long-term use of sensitive muscles, but the skin care products generally only act on the epidermis layer of sensitive skin, and the epidermis layer has certain effects of relieving and diminishing inflammation.
It is well known that sensitive skin is susceptible because the skin barrier function is impaired, the skin barrier function depends on restoration of the epidermis layer of the skin and the thickness of the skin, and the thickness restoration of the skin depends on the restoration self-healing ability of cells of the dermis layer. If the skin care product only has certain relieving and anti-inflammatory effects on the epidermis, the skin care product probably has a certain skin barrier repairing effect after long-term use, and the improvement of the skin state is shown, but the skin care product can not improve the repairing self-healing capability of cells of the dermis layer, the skin barrier is still weak, the skin barrier is still lack of tolerance to external stimulus, and various allergic symptoms such as redness, skin lifting, tightening, itching and the like still easily occur when the skin is subjected to the external stimulus, so that the skin is always in a sensitive state and in a normal state in the continuous circulation process.
In view of the above-mentioned related art, the applicant has perceived the need to develop a skin care product for sensitive skin which is capable of completely repairing the skin barrier function and thereby improving skin tolerance.
Disclosure of Invention
In order to completely repair the barrier function of the skin and thereby improve the tolerance of the skin, the present application provides a soothing repair composition, a soothing repair milk and a preparation method thereof. The application surprisingly finds that the composition of the magnesium ascorbyl phosphate, the coastal cress callus culture filtrate, the rooftop grown grass extract and the ruscus aculeatus root extract has the unexpected technical effects of improving the repair self-healing capacity of the dermis cells and improving the activity of the dermis cells, and the long-term use of the soothing repair composition containing the composition of the magnesium ascorbyl phosphate, the coastal cress callus culture filtrate, the rooftop grown grass extract and the ruscus aculeatus root extract can promote the stratum corneum of sensitive skin to be obviously thickened, promote the dermis cells to be arranged more tightly, promote the boundary between the epidermis and the dermis to be clearer, and achieve the effects of obviously increasing the thickness of the sensitive skin, repairing the skin barrier of the sensitive skin and improving the tolerance of the sensitive skin.
In a first aspect, the present application provides a soothing repair composition, which adopts the following technical scheme:
the composition for relieving and repairing comprises the following components in percentage by mass: 3 to 8 percent of magnesium ascorbyl phosphate, 1 to 5 percent of coastal cress callus culture filtrate, 1 to 5 percent of roof growing grass extract, 1 to 5 percent of false leaf tree root extract and the balance of solvent.
In the technical scheme, the magnesium ascorbyl phosphate has good technical effects of eliminating free radicals and inhibiting tyrosinase activity, and the magnesium ascorbyl phosphate has good whitening, anti-inflammation and anti-aging effects. The coastal cress callus culture filtrate has strong antioxidant capacity, which endows the coastal cress callus culture filtrate with good skin barrier repairing effect. The extracts of the longhairy antenoron herb and the false leaf tree root have good moisturizing and soothing effects on sensitive skin.
The composition comprises magnesium ascorbyl phosphate, the coastal cress callus culture filtrate, the rooftop grown grass extract and the false leaf tree root extract, and the magnesium ascorbyl phosphate, the coastal cress callus culture filtrate, the rooftop grown grass extract and the false leaf tree root extract are mutually cooperated to jointly exert good anti-inflammatory effect from different mechanisms, meanwhile, the composition has the technical effects of remarkably improving the repair self-healing capacity of dermal cells, improving the activity of dermal cells, promoting the cell arrangement to be more compact, obviously increasing the skin thickness after long-term use, repairing the skin barrier, improving the skin tolerance, truly realizing the improvement of the skin state of sensitive skin from the root source, ensuring that the sensitive skin can not generate various allergic symptoms such as redness, skin lifting, tightening, itching and the like when facing non-strong stimulation, and ensuring that the sensitive skin can maintain normal and stable good skin state for a long time.
Preferably, the soothing repair composition comprises the following components in mass percent: 3 to 6 percent of magnesium ascorbyl phosphate, 1 to 3 percent of coastal cress callus culture filtrate, 1 to 3 percent of roof growing grass extract, 1 to 3 percent of false leaf tree root extract and the balance of solvent.
In the technical scheme, the dosage ranges of the magnesium ascorbyl phosphate, the coastal cress callus culture filtrate, the roof growing grass extract and the ruscus aculeatus root extract are further optimized, so that the technical effects of improving the repair self-healing capacity of the dermis layer cells, improving the activity of the dermis layer cells and promoting the secretion of protein of the soothing repair composition are further enhanced.
Preferably, the soothing repair composition further comprises the following components in mass percent: 0.4 to 0.8 percent of ceramide NP, 0.01 to 0.1 percent of recombinant III type collagen, 0.001 to 0.01 percent of decapeptide-4 and 0.001 to 0.01 percent of glycoprotein.
According to the technical scheme, the ceramide NP, the recombinant III type collagen, the decapeptide-4 and the glycoprotein are further added into the soothing and repairing composition, the good effect of repairing the sebum membrane by the ceramide NP, the decapeptide-4 and the glycoprotein is achieved, the good moisturizing effect of the recombinant III type collagen is achieved, the soothing effect of the soothing and repairing composition on the skin is further improved, and the repairing efficiency of the skin barrier is further accelerated by matching with magnesium ascorbate phosphate, the coastal cress callus culture filtrate, the roof grass extract and the ruscus aculeatus root extract, so that the skin can build tolerance more quickly, and the skin state of sensitive skin can be improved from root to root truly.
The application further discovers in the research that the combination of the littoral cress callus culture filtrate, the recombinant III type collagen and the glycoprotein can obviously promote the generation of FLG protein and LOR protein in skin, promote sensitive skin to quickly build a epidermis layer structure network at a skin injury part, better eliminate skin micro-wounds, enhance skin self-healing capacity, quickly eliminate sensitive skin facial injury, and further improve the skin barrier restoration speed of the composition for relieving and restoring and delay skin aging.
Preferably, the soothing repair composition further comprises the following components in mass percent: 0.4 to 0.5 percent of ceramide NP, 0.01 to 0.05 percent of recombinant III type collagen, 0.001 to 0.005 percent of decapeptide-4 and 0.001 to 0.005 percent of glycoprotein.
According to the technical scheme, the dosage range of the ceramide NP, the recombinant III type collagen, the decapeptide-4 and the glycoprotein is further optimized, so that the ceramide NP, the recombinant III type collagen, the decapeptide-4 and the glycoprotein can be better matched with other components in the soothing repair composition, the repair speed of the soothing repair composition to sensitive skin barriers is further accelerated, the sensitive skin can quickly build tolerance, the sensitive skin has better resisting effect on external stimulus, and the sensitive skin can maintain a stable good skin state for a long time.
Preferably, the solvent is butanediol.
According to the technical scheme, the butanediol is specifically selected as the solvent of the soothing and repairing composition, so that the components in the soothing and repairing composition can be fully dissolved and uniformly mixed, and the butanediol has certain moisturizing and antibacterial effects on the skin, so that other components in the soothing and repairing composition can be better cooperated, the soothing and repairing composition can be better used for repairing the skin barrier of sensitive skin, and the technical effects of improving the tolerance of the sensitive skin can be achieved.
In a second aspect, the present application provides a soothing repair emulsion adopting the following technical scheme:
the soothing repair emulsion comprises the following components in percentage by mass: 7 to 12 percent of humectant, 0.2 to 0.5 percent of thickener, 0.01 to 0.03 percent of chelating agent, 1.1 to 2.3 percent of emulsifier, 4.5 to 12 percent of emollient, 0.1 to 0.5 percent of p-hydroxyacetophenone, 0.1 to 0.5 percent of hexanediol, 2 to 5 percent of soothing repair composition and the balance of water.
According to the technical scheme, the soothing repair composition is added into the soothing repair emulsion, so that a good effect of repairing the skin barrier of the sensitive skin can be achieved, the establishment of good skin tolerance of the sensitive skin is promoted, and the sensitive skin is further promoted to maintain a stable good skin state for a long time.
Preferably, the emollients include cetostearyl alcohol, caprylic/capric triglyceride, shea butter and polydimethylsiloxane.
In the technical scheme, cetostearyl alcohol, caprylic/capric triglyceride, shea butter and polydimethylsiloxane are specifically selected as emollients of the soothing and repairing emulsion, so that the skin surface can be kept wet for a long time, the skin surface is not dry and tight and is not skinned, the soothing and repairing composition can be matched better, and the soothing and repairing emulsion is promoted to exert a better technical effect of repairing the skin barrier of sensitive skin.
In a third aspect, the present application provides a preparation method of a soothing repair emulsion, which adopts the following technical scheme:
a preparation method of a soothing repair emulsion comprises the following steps:
step 1: mixing water, humectant, p-hydroxyacetophenone, thickener and chelating agent, heating to 80-85 ℃, homogenizing and dispersing uniformly to obtain a first material; mixing an emulsifying agent and an emollient, heating to 80-85 ℃, homogenizing, dispersing and uniformly stirring to obtain a second material body;
step 2: mixing and homogenizing the first material body and the second material body for 5-8 min, vacuumizing, and stirring at a constant temperature of 80-85 ℃ for 15-20 min;
step 3: cooling to 35-40 ℃, adding hexanediol, and stirring uniformly to obtain the soothing and repairing emulsion.
According to the technical scheme, the components of the soothing repair emulsion prepared through the steps can be fully and uniformly mixed, and the technical effect of repairing sensitive skin can be better and synergistically exerted.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the preparation method comprises the steps of combining ascorbyl magnesium phosphate, coastal cress callus culture filtrate, a roof growing grass extract and a false leaf tree root extract to form a relieving repair composition, combining the ascorbyl magnesium phosphate, the coastal cress callus culture filtrate, the roof growing grass extract and the false leaf tree root extract to play a good relieving anti-inflammatory role from different mechanisms, and meanwhile, the preparation method has the technical effects of remarkably improving the repair self-healing capacity of dermal cells, improving the activity of dermal cells, promoting the cell arrangement to be more compact, obviously increasing the skin thickness after long-term use, repairing the skin barrier, improving the skin tolerance, truly realizing the effect of radically improving the skin state of sensitive skin, ensuring that the sensitive skin does not have various allergic symptoms such as redness, skin lifting, tightening, itching and the like when facing non-strong stimulation, and ensuring that the sensitive skin can maintain a normal and stable good skin state for a long time.
2. The preparation method remarkably promotes the generation of FLG protein and LOR protein in skin through the compounding of the littoral celery callus culture filtrate, the recombinant III type collagen protein and the glycoprotein, promotes sensitive skin to rapidly establish a epidermis layer structure network at a skin injury position, better eliminates fine wounds of the skin, enhances the self-healing capacity of the skin, can rapidly eliminate facial injury of the sensitive skin, and achieves the technical effects of further improving the repair speed of the skin barrier by the soothing repair composition and delaying skin aging.
3. According to the skin-care cream, cetostearyl alcohol, caprylic/capric triglyceride, shea butter and polydimethylsiloxane are specifically selected as the skin-care cream, so that the skin surface can be kept wet for a long time, the skin surface is not dry and tight and is not skinned, the skin-care composition can be matched with the skin-care cream better, and the skin-care cream is promoted to exert better technical effects of repairing the skin barrier of sensitive skin.
Drawings
FIG. 1 is the H & E staining pattern results of example 6 in experiment 1.
FIG. 2 is a photograph of the result of FLG immunofluorescence assay of example 6 in experiment 2.
FIG. 3 is a photograph of the result of LOR immunofluorescence assay of example 6 in experiment 2.
Detailed Description
For a better description of the objects, technical solutions and advantages of the present invention, the present invention will be further described with reference to the following specific examples.
Example 1
A soothing repair composition comprises 94kg butanediol, 3kg magnesium ascorbyl phosphate, 1kg littoral callus culture filtrate, 1kg herba Achilleae extract, 1kg Ruscus aculeatus root extract.
Among them, coastal cress callus culture filtrate was purchased from Ansai Bo (Chongqing) Biotechnology Co.
Wherein, the rooftop grass extract is purchased from qu city-exhibition macro biotechnology limited company.
Wherein the extract of the root of the Ruscus aculeatus is purchased from Quzhou market display macro biotechnology Co.
The preparation method of the soothing and repairing composition comprises the following steps: and uniformly mixing the components at normal temperature to obtain the relieving and repairing composition.
Example 2
A soothing repair composition differs from example 1 in that it comprises 77kg butanediol, 8kg magnesium ascorbyl phosphate, 5kg of a culture filtrate of a coastal parsley callus, 5kg of an extract of a plant of the Dioscorea nipponica, 5kg of an extract of a root of a Ruscus aculeatus.
Example 3
A soothing repair composition differs from example 1 in that it comprises 89kg butanediol, 5kg magnesium ascorbyl phosphate, 2kg of a culture filtrate of coastal parsley callus, 2kg of an extract of Dioscorea nipponica Makino, 2kg of an extract of Dioscorea pekinensis root.
Example 4
A soothing repair composition differs from example 3 in that it further comprises 0.4kg of ceramide NP, 0.01kg of recombinant type III collagen, 0.001kg of decapeptide-4, 0.001kg of glycoprotein, and the addition amount of butanediol is 88.588kg.
Wherein, the recombinant type III collagen TTA1-01 is purchased from Jiangsu Chuangjian medical science and technology Co.
Example 5
A soothing repair composition differs from example 3 in that it further comprises 0.8kg of ceramide NP, 0.1kg of recombinant type III collagen, 0.01kg of decapeptide-4, 0.01kg of glycoprotein, and the addition amount of butanediol is 88.08kg.
Example 6
A soothing repair composition differs from example 3 in that it further comprises 0.5kg of ceramide NP, 0.05kg of recombinant type III collagen, 0.005kg of decapeptide-4, 0.005kg of glycoprotein, and the addition amount of butanediol is 88.44kg.
Example 7
A soothing repair composition differs from example 6 in that the recombinant type III collagen, glycoprotein are replaced with butanediol in equal amounts.
Example 8
A soothing repair composition differs from example 6 in that the recombinant type III collagen is replaced by butanediol in equal amounts.
Example 9
A soothing repair composition differs from example 6 in that the glycoprotein is replaced by butanediol in equal amounts.
Comparative example 1
A soothing repair composition differs from example 3 in that magnesium ascorbyl phosphate is replaced by butanediol in equal amounts.
Comparative example 2
A soothing repair composition differs from example 3 in that the coastal cress callus culture filtrate is replaced by butanediol in equal amounts.
Comparative example 3
A soothing repair composition differs from example 3 in that the extract of Dilute grass is replaced by butanediol in equal amounts.
Comparative example 4
A soothing repair composition differs from example 3 in that the root extract of the Ruscus aculeatus is replaced by butanediol in equal amounts.
Comparative example 5
A soothing repair composition differs from example 6 in that the coastal cress callus culture filtrate is replaced by butanediol in equal amounts.
Application example 1
A soothing repair emulsion comprising 76.99kg water, 4kg glycerin, 8kg butylene glycol, 0.2kg ammonium acryloyldimethyl taurate/VP copolymer, 0.01kg disodium edetate, 1kg glyceryl stearate citrate, 0.1kg potassium cetyl phosphate, 0.5kg cetostearyl alcohol, 3kg caprylic/capric triglyceride, 0.5kg shea butter, 0.5kg dimethicone, 0.1kg p-hydroxyacetophenone, 0.1kg hexylene glycol, 5kg soothing repair composition.
Wherein the humectant is glycerin and butylene glycol.
Wherein the thickener is an ammonium acryloyldimethyl taurate/VP copolymer.
Wherein the chelating agent is disodium edetate.
Wherein the emulsifier is glyceryl stearate citrate, cetyl alcohol phosphate potassium.
Wherein the emollient is cetostearyl alcohol, caprylic/capric triglyceride, butter fruit, or polydimethylsiloxane.
Wherein the preservative is p-hydroxyacetophenone or hexanediol.
Wherein a soothing repair composition was prepared as in example 1.
The preparation method of the soothing repair emulsion comprises the following steps:
step 1: mixing water, humectant, p-hydroxyacetophenone, thickener and chelating agent, heating to 85deg.C, and homogenizing and dispersing for 15min at 2200r/min to obtain a first material; mixing the emulsifier and the emollient, heating to 85 ℃, and homogenizing and dispersing for 15min at 2200r/min to obtain a second material body.
Step 2: after the first material and the second material are mixed and 2200r/min are homogenized for 5min, the mixture is vacuumized and stirred at a constant temperature of 85 ℃ for 15min at 220 r/min.
Step 3: cooling to 40deg.C, adding hexanediol, stirring at 220r/min for 5min to obtain the final product.
Application example 2
A soothing repair emulsion, unlike application example 1, comprises 76.17kg of water, 2kg of glycerin, 4kg of butylene glycol, 0.5kg of ammonium acryloyldimethyl taurate/VP copolymer, 0.03kg of disodium ethylenediamine tetraacetate, 2kg of glyceryl stearate citrate, 0.3kg of potassium cetyl phosphate, 2kg of cetostearyl alcohol, 6kg of caprylic/capric triglyceride, 2kg of shea butter, 2kg of polydimethylsiloxane, 0.5kg of p-hydroxyacetophenone, 0.5kg of hexylene glycol, 2kg of a soothing repair composition.
Wherein a soothing repair composition was prepared as in example 1.
The preparation method of the soothing repair emulsion comprises the following steps:
step 1: mixing water, humectant, p-hydroxyacetophenone, thickener and chelating agent, heating to 80deg.C, homogenizing at 2000r/min for 20min to obtain a first material; mixing the emulsifier and the emollient, heating to 80 ℃, homogenizing and dispersing for 20min at 2000r/min to obtain a second material body.
Step 2: mixing the first material and the second material, homogenizing at 2000r/min for 8min, vacuumizing, and stirring at 200r/min at constant temperature of 80deg.C for 18min.
Step 3: cooling to 35deg.C, adding hexanediol, stirring at 200r/min for 8min to obtain the final product.
Application example 3
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 2.
Application example 4
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 3.
Application example 5
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 4.
Application example 6
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 5.
Application example 7
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 6.
Application example 8
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 7.
Application example 9
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 8.
Application example 10
A soothing repair emulsion differs from application example 1 in that a soothing repair composition is prepared in example 9.
Comparative application example 1
A soothing repair emulsion differs from application example 1 in that a soothing repair composition was prepared in comparative example 1.
Comparative application example 2
A soothing repair emulsion is different from application example 1 in that a soothing repair composition is prepared in comparative example 2.
Comparative application example 3
A soothing repair emulsion is different from application example 1 in that a soothing repair composition is prepared in comparative example 3.
Comparative application example 4
A soothing repair emulsion is different from application example 1 in that a soothing repair composition is prepared in comparative example 4.
Comparative application example 5
A soothing repair emulsion differs from application example 1 in that a soothing repair composition was prepared in comparative example 5.
Experiment 1 effect verification experiment principle of soothing repair composition: the experiment is based on the barrier principle, utilizes a 3D skin model (EpiKutis, lot number: ES 210202), adopts a surface administration mode (a mode of simulating human body exposure), and evaluates the effect of a sample to be tested on improving the skin barrier by detecting the change of the tissue morphology of the skin model and the change of the content of FLG and LOR proteins.
Sample to be measured: the soothing repair composition of each example and comparative example.
The experimental method comprises the following steps: the experiment is divided into 16 groups, wherein 1 group is a blank control group, 1 group is a positive control group, and 14 groups are sample groups to be detected. The 3D model was placed in 6-well plates (0.9 mL of model broth added in advance) and labeled according to experimental groupings.
The experimental group takes 25 mu L of a sample to be detected and adds the sample to be detected on the surface of a model, shakes the model lightly to ensure that the sample is uniformly distributed on the surface of the model, incubate the model for 24 hours in a carbon dioxide incubator at 37 ℃ and 5% carbon dioxide concentration, then wash the residual test object on the surface of the model by using a wash bottle filled with sterile PBS solution, and wipe the residual liquid inside and outside the model lightly by using a sterile cotton swab.
The blank control group is different from the experimental group in that 25 mu L of model culture solution is added on the surface of the model; the positive control group was different from the experimental group in that 25. Mu.L of positive control solution was applied to the surface of the model, and the positive control solution was prepared as follows: 10mg of WY14643 powder was weighed and dissolved in 1mL of DMSO to prepare 30mM WY14643 mother liquor, and 5. Mu.L of WY14643 mother liquor was added to 3mL of the model culture broth to prepare 3mL of 50. Mu.M positive control solution.
Verification 1: fixing the model with 4% paraformaldehyde for 24 hours, performing H & E dyeing treatment on the model, photographing and observing by a microscope (Olympus, CKX 41), and evaluating the effect, wherein 5 points represent that the skin is thickened obviously, the cells at the muscle base are arranged very tightly, and the boundaries of the four layers of skin structures are very clear; 4 points represent that the skin is obviously thickened, the arrangement of cells at the muscle base is compact, and the skin structure boundary is clear; 3 points represent skin thickening, the arrangement of myobasal cells is compact, and the skin structure boundary is clear; 2 points represent that the skin thickening effect is not obvious, the close arrangement effect of the cells at the muscle base is poor, and the definition of the skin structure boundary is poor; 1 is the fact that the skin thickening phenomenon is difficult to observe, the phenomenon that the cells at the muscle base are closely arranged is difficult to observe, and the skin structure boundary is unclear; the 0's point indicates that the skin has no thickening phenomenon, the myoblasts have no tight arrangement phenomenon, the skin structure boundary is not clear, and the experimental results are shown in Table 1.
Verification 2: the paraffin slice is placed in a slice baking machine at 70 ℃ for 4 hours, then the slice is placed in xylene for 10 minutes, the xylene is replaced and then soaked for 10 minutes, the slice is soaked in absolute ethyl alcohol for 5 minutes, the slice is soaked in 95% ethanol for 5 minutes, and PBS buffer solution is washed for 3 times, each time for 5 minutes. Then Gu Ang paraffin sections are put into a 0.01M sodium citrate antigen retrieval solution, high-pressure retrieval is adopted, the sections are taken out after cooling, and the sections are washed for 3 times with PBS buffer solution for 5min each time. Then, 1 drop of 3% hydrogen peroxide solution was added to each slice, incubated at room temperature for 30min, washed 3 times with PBS buffer for 5min each, and blocked for 60min at 37℃with serum homologous to the secondary antibody. Then, primary antibody incubation, secondary antibody incubation, nuclear staining (host 33342 working solution) were performed, photographs were taken (20×) with a fluorescence microscope (Leica, DM2500 LED), and the Integral Optical Density (IOD) of the blank control group was taken as 1, and FLG relative IOD value and LOR relative IOD value were counted, respectively, and the experimental results are shown in table 1.
Table 1:
by combining examples 1-9, comparative examples 1-5, table 1 and FIGS. 1-3, it can be seen that the soothing and repairing composition compounded by magnesium ascorbyl phosphate, a filtrate of a culture of coastal cress callus, an extract of Dioscorea nipponica Makino and an extract of Dioscorea nipponica Makino has the technical effects of remarkably promoting the cell arrangement to be more compact and increasing the skin thickness, the soothing and repairing composition compounded by magnesium ascorbyl phosphate, coastal cress callus culture filtrate, a housetop grass extract, a ruscus aculeatus root extract, ceramide NP, recombinant type III collagen, decapeptide-4 and glycoprotein has the technical effects of remarkably increasing skin thickness and promoting the generation of FLG protein and LOR protein.
By combining example 3, comparative examples 1 to 4 and Table 1, it can be obtained that the compounding of magnesium ascorbyl phosphate, the filtrate of the culture of coastal cress callus, the extract of roof grown grass and the extract of root of ruscus aculeatus has specificity, and only the compounding of the four has the technical effects of remarkably improving the repair self-healing capacity of dermis cells, improving the activity of dermis cells and promoting the cell arrangement to be more compact, and the skin barrier can be obviously increased, and the skin tolerance can be improved by using the soothing and repairing composition for a long time.
By combining examples 3, 4-6, 7-9, comparative example 5 and Table 1, it can be obtained that the compounding of the littoral cress callus culture filtrate, the recombinant III type collagen and the glycoprotein has specificity, can remarkably promote the generation of FLG protein and LOR protein in skin, promote sensitive skin to rapidly build up a epidermis layer structure network at a skin injury site, and further cooperate with magnesium ascorbate phosphate, a roof long grass extract and a ruscus aculeatus root extract, can further accelerate the repair efficiency of skin barriers, enable the skin to build tolerance more rapidly, and truly realize rapid root improvement of the skin state of the sensitive skin.
Experiment 2 test subjects verify the effect of soothing the repair milk: 150 sensitive skin volunteers aged 25-40 years old have normal endocrine, severe red blood streak and dry desquamation of facial skin, and are accompanied by symptoms of tightness, stinging, burning, etc.
The experimental method comprises the following steps: the test subjects were equally divided into 15 groups, and each group of test subjects used the above-mentioned application examples respectively in the morning and evening for 15 days in comparison with the modified milk in the application example, and no other skin care products or medicines containing antiallergic or hormonal components were used during the experiment.
Verification 1: evaluating skin allergy conditions on the 1 st day, the 5 th day, the 10 th day and the 15 th day after use, wherein severe allergy represents that the area of red blood filaments of the face exceeds 70%, and dry desquamation is generated; the moderate sensitization represents 50% -70% of the area of the red blood streak of the face, and has the phenomenon of dry desquamation; allergy represents 30% -50% of the area of facial red blood streaks, and has the phenomenon of partial dryness and desquamation; mild allergy represents facial red blood streak areas of less than 30%, with little or no dry desquamation; slight allergy represents a facial red blood streak area of less than 10% without dry desquamation; the normal face is free of allergy, and the experimental results are shown in Table 2.
Verification 2: the subjects were tested for lactic acid stimulation on day 15, and a filter paper (about 0.8cm in diameter) saturated with 50 μl of a 10% lactic acid solution was applied to the nasolabial folds (the nasolabial folds were more sensitive), and the subjects were asked for a burning sensation and scored, wherein 0=no sensation, 1=a slight sensation, 2=a moderate sensation, 3=a strong sensation, and if the burning sensation lasted more than 30s and scored for 3 hours, the lactic acid stimulation test was positive, otherwise negative, and the test results are shown in table 2.
Table 2:
by combining application examples 1 to 10, comparative examples 1 to 5 and table 2, it can be found that by adding the soothing repair composition prepared in the present application to the soothing repair milk, the effect of the soothing repair milk to repair the skin barrier of the sensitive skin well can be imparted, the establishment of good skin tolerance of the sensitive skin can be promoted, and further the maintenance of a stable good skin state of the sensitive skin can be promoted for a long period of time.
The present embodiment is merely illustrative of the present application and is not intended to be limiting, and those skilled in the art, after having read the present specification, may make modifications to the present embodiment without creative contribution as required, but is protected by patent laws within the scope of the claims of the present application.
Claims (7)
1. A soothing repair composition, characterized by comprising the following components in mass percent: 3% -8% of magnesium ascorbyl phosphate, 1% -5% of coastal cress callus culture filtrate, 1% -5% of roof growing grass extract, 1% -5% of ruscus aculeatus root extract and the balance of solvent.
2. A soothing repair composition according to claim 1, characterized in that it comprises the following components in mass percent of the soothing repair composition: 3% -6% of magnesium ascorbyl phosphate, 1% -3% of coastal cress callus culture filtrate, 1% -3% of roof growing grass extract, 1% -3% of ruscus aculeatus root extract and the balance of solvent.
3. A soothing repair composition according to claim 1, characterized in that it further comprises, in mass percent of the soothing repair composition: 0.4% -0.8% of ceramide NP, 0.01% -0.1% of recombinant III-type collagen, 0.001% -0.01% of decapeptide-4 and 0.001% -0.01% of glycoprotein.
4. A soothing repair composition according to claim 3, characterized in that it further comprises, in mass percent of the soothing repair composition: 0.4% -0.5% of ceramide NP, 0.01% -0.05% of recombinant III-type collagen, 0.001% -0.005% of decapeptide-4 and 0.001% -0.005% of glycoprotein.
5. A soothing repair composition according to claim 1 wherein the solvent is butylene glycol.
6. The soothing repair emulsion is characterized by comprising the following components in percentage by mass: 7% -12% of humectant, 0.2% -0.5% of thickener, 0.01% -0.03% of chelating agent, 1.1% -2.3% of emulsifier, 4.5% -12% of emollient, 0.1% -0.5% of p-hydroxyacetophenone, 0.1% -0.5% of hexanediol, 2% -5% of the soothing repair composition according to any one of claims 1-5, and the balance of water.
7. A soothing repair emulsion according to claim 6 wherein the emollient comprises cetostearyl alcohol, caprylic/capric triglyceride, shea butter and polydimethylsiloxane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3439743A2 (en) * | 2016-04-07 | 2019-02-13 | Botanica GmbH | Composition comprising houseleek (sempervivum tectorum l.) extract, preparation processes and uses thereof |
| CN112941010A (en) * | 2021-01-30 | 2021-06-11 | 湖北嘉弘福科技有限责任公司 | Plant callus efficacy filtrate and exosome extraction method |
| CN114762672A (en) * | 2021-05-31 | 2022-07-19 | 安婕妤化妆品科技股份有限公司 | Soothing composition, toning lotion and preparation method thereof |
| CN116115659A (en) * | 2022-11-25 | 2023-05-16 | 安赛搏(重庆)生物技术有限公司 | Extraction method and application of coastal cress callus extract |
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| US20040005342A1 (en) * | 2002-02-07 | 2004-01-08 | Societe L'oreal S.A. | Topical administration of ascorbic acid to reinforce the cohesion of the dermo-epidermal junction |
| US9801900B2 (en) * | 2013-11-22 | 2017-10-31 | Mary Kay Inc. | Compositions for sensitive skin |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3439743A2 (en) * | 2016-04-07 | 2019-02-13 | Botanica GmbH | Composition comprising houseleek (sempervivum tectorum l.) extract, preparation processes and uses thereof |
| CN112941010A (en) * | 2021-01-30 | 2021-06-11 | 湖北嘉弘福科技有限责任公司 | Plant callus efficacy filtrate and exosome extraction method |
| CN114762672A (en) * | 2021-05-31 | 2022-07-19 | 安婕妤化妆品科技股份有限公司 | Soothing composition, toning lotion and preparation method thereof |
| CN116115659A (en) * | 2022-11-25 | 2023-05-16 | 安赛搏(重庆)生物技术有限公司 | Extraction method and application of coastal cress callus extract |
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