CN1167358C - 治疗压迫溃疡的营养组合物 - Google Patents

治疗压迫溃疡的营养组合物 Download PDF

Info

Publication number
CN1167358C
CN1167358C CNB998008508A CN99800850A CN1167358C CN 1167358 C CN1167358 C CN 1167358C CN B998008508 A CNB998008508 A CN B998008508A CN 99800850 A CN99800850 A CN 99800850A CN 1167358 C CN1167358 C CN 1167358C
Authority
CN
China
Prior art keywords
milligram
composition
equivalent
daily dose
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB998008508A
Other languages
English (en)
Other versions
CN1272043A (zh
Inventor
�����ǡ����ǡ��Ѷ�������-����
玛丽亚·安那·费尔霍伊尔－科特
�����տˡ���������
昌塔尔·内勒克·克洛伊尔
����� ��Լ����Լɪ�
罗伯特·约翰·约瑟夫·哈格曼
�����ҡ���������
鲁洛夫·安德烈·博克
莫尔德·格塔尔斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nutricia NV
Original Assignee
Nutricia NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8233719&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1167358(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nutricia NV filed Critical Nutricia NV
Publication of CN1272043A publication Critical patent/CN1272043A/zh
Application granted granted Critical
Publication of CN1167358C publication Critical patent/CN1167358C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pediatric Medicine (AREA)
  • Botany (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Invalid Beds And Related Equipment (AREA)
  • Massaging Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

本发明公开了一种适用于治疗压迫溃疡的营养辅助组合物，其含有蛋白质、碳水化合物和脂肪，且其日剂量中含有：3-15克精氨酸或其等同物，180-840毫克抗坏血酸等同物，50-400毫克α-生育酚等同物，且还含有：0.8-16毫克类胡萝卜素、无机物和/或8-40毫克黄酮类化合物，所述无机物添加量为：钠120-2400毫克、氯化物180-2000毫克、钾200-2000毫克、钙300-1500毫克、磷200-1400毫克以及镁80-600毫克。该组合物日剂量中还可含有8-80毫克锌，以及一些其它化合物。

Description

治疗压迫溃疡的营养组合物
技术领域
本发明涉及一种适于治疗及防止压迫溃疡的营养组合物。
背景技术
压迫溃疡(褥疮)较经常发生，特别是在那些不得不长期卧床的外科病人和不能运动的人，如部分老年人中。人体的一些部位，例如肘、足跟、髋部、尾骨、肩胛骨会受到身体重量的压力作用。严重的压迫溃疡可分为几个阶段：第一阶段，压力和剪切力引起了皮下组织的收缩、毛细管和***的闭塞以及在深组织层形成较差的血管分布。长期的压力引起皮肤表层组织的损伤，从而减少了表皮细胞的生成并使皮肤变薄，皮肤的血管受到损害并使皮肤发红；第二阶段，基膜从表皮脱落，引起水肿和水疱；第三阶段，表皮损坏更严重，并影响了皮肤表层；下一阶段，在皮肤表面可观察到深组织层的坏死。由于外科手术后的营养不充分、营养不良、伤口组分的损失、不能运动、体质虚弱或其它障碍，通常导致褥疮病人的营养条件差。
防止和治愈压迫溃疡首先需要改善伤口面的外部因素，如减少压力、摩擦和剪切力、湿度和温度。
EP-A-564804中公开了一种通过使用锌、维生素A和C、硒、β-胡萝卜素和硫胺素促进伤口愈合的方法。可使用含62.5克/升(25能量％)蛋白质、34克/升(30能量％)脂肪和113克/升(45能量％)碳水化合物的液体组合物。该组合物也可含有其它维生素和痕量元素。在这种改善伤口愈合所需条件下提及了压迫溃疡。
EP-A-367724公开了每单位剂量(1.5升)中含3-40克(18.75克)精氨酸、0.1-4克(1.9克)RNA、0.1-20克(3克)ω-3多不饱和脂肪酸(pufa’s)的免疫刺激组合物，其中ω-3多不饱和脂肪酸含1-2克EPA、0.25-1克DHA和0.1-20克(3.6克)ω-6不饱和脂肪酸(亚油酸)。该组合物含22能量％的蛋白质、28能量％的脂肪和53能量％的碳水化合物。在这种免疫刺激组合物的适用情况中并没有提及压迫溃疡。
US5,053,387公开了一种治疗外伤的组合物，该组合物含有精氨酸(1-3能量％)、完整蛋白质(20-30能量％)、脂肪(7-15能量％，含ω-6/ω-3比率约1.5的EPA和亚油酸)和碳水化合物(65-70能量％)，还含有锌、维生素A和维生素C。
在WO 93/16595中公开了一种含精氨酸的液体营养组合物，可用于外伤和外科病人，但不包括压迫溃疡病人。该组合物含有20能量％的蛋白质、24能量％脂肪和56能量％的碳水化合物。精氨酸提供了能量的1-3能量％。亚油酸与α-亚油酸的比率介于3.5-5.5。热量密度为1.2-1.5千卡/毫升，卡(路里)对氮的比率介于112-145。组合物还含有1-2倍于推荐日用量的维生素和痕量元素。
WO 96/08966公开了一种通过一氧化氮(NO)型化合物加速伤口愈合的方法，该方法包括摄入NO型加速化合物如亚硝基化胺、有机抗氧剂如维生素C和E以及其它组分如止痛剂。在该文献中并未提到压迫溃疡和营养组合物。
发明内容
现已发现能有效抗压迫溃疡的组合物应含有一组营养素，这些营养素不仅可促进伤口愈合，还能在前述阶段中改善血液循环并控制炎症。这种有效组合物，当以液体形式存在时，应含有精氨酸(3-15克/升，优选5-10克/升)、维生素C(3-14倍于推荐日剂量，RDA)、维生素E(5-40倍于RDA)，并优选含有至少8毫克/升或/天的锌，并具有适当锌/铜比率。进一步改进的组合物还含有增加剂量的类胡萝卜素、无机物(Na、K、Cl)和/或黄酮类化合物(8-40毫克/升)。具体地说，本发明提供一种适用于治疗压迫溃疡的营养辅助组合物，其含有蛋白质、碳水化合物和脂肪，且其日剂量中含有：3-15克精氨酸或其等同物，180-840毫克抗坏血酸等同物，50-400毫克α-生育酚等同物，且还含有：0.8-16毫克类胡萝卜素、无机物和/或8-40毫克黄酮类化合物，所述无机物添加量为：钠120-2400毫克、氯化物180-2000毫克、钾200-2000毫克、钙300-1500毫克、磷200-1400毫克以及镁80-600毫克。
具体实施方式
本发明组合物中所用的精氨酸可为游离氨基酸形式，或为富含精氨酸的肽或蛋白质如豌豆蛋白质，或为精氨酸的代谢物等同物如鸟尿酸或瓜氨酸形式。精氨酸的用量为3-15克/天，优选5-10克/天。
此处所述的维生素C的级别为抗坏血酸等同物，可含有维生素C(抗坏血酸)和可在体内转化为抗坏血酸的化合物，如脱氢抗坏血酸、坏血酸棕榈酸酯和其它抗坏血酸酯。抗坏血酸等同物的用量从180毫克/天或200毫克/天高达至840毫克/天或更多。优选的范围为300-780毫克/天，更优选350-700毫克/天。
此处所述的维生素E的级别为生育酚等同物，可含有α-生育酚及其等同物。因此，1毫克α-生育酚等同物(TE)(＝1.5IU的维生素E)对应于1毫克D-α-生育酚、2.0毫克D-β-生育酚、10毫克D-γ-生育酚、30毫克D-δ-生育酚、2毫克D-α-生育三烯酚或18.6毫克D-β-生育三烯酚。生育酚等同物的用量为50-400毫克/天。优选最小用量为100毫克/天，更优选为120毫克/天，特别优选为180毫克/天，优选的最高限度为320毫克/天，更优选250毫克/天。
上述组合物的效力还可通过添加黄酮类化合物而提高，例如8-40毫克/天，特别是10-30毫克/天。根据本发明，黄酮类化合物可理解为含有具有黄酮结构(2-苯基-色酮＝2-苯基-苯并吡喃酮)的羟基取代的化合物及其异构体，如异黄酮类(3-苯基色酮类)、查耳酮类(2-肉桂酰-苯酚类)和奥弄类(2-次苯甲基-苯并呋喃酮)。黄酮类化合物中也可含花色素(由于吡喃鎓部分代替了吡喃酮部分，因此其不同于黄酮)。在天然化合物中，如花色素类(＝糖基化花色素类)和糖基化黄酮醇类，黄酮类化合物的羟基官能团优选为部分烷基化或糖基化。这些黄酮类化合物中，优选黄酮醇，特别优选黄酮四醇和更高级羟基化的类似物，如山奈酚、栎精和杨梅酮(myrecitin)，并优选甲基化类似物，如华报春花苷(sinensetin)、柑桔黄酮和川皮苷，以及糖甙如芸香甙和杨梅甙。这些异黄酮类化合物中，黄豆甙原和金雀异黄素是优选的化合物。花色素类化合物中，优选芍药素、花色素、花葵素、翠雀次碱、3’-甲花翠素和缬胆碱(valvidin)。黄烷酮(＝2，3-二氢黄酮类)如橙皮素和柚皮甙是其它优选的黄酮类化合物。使用黄酮类的混合物，如天然植物的抽提物或植物(如柑橘属果树、茶叶、葡萄)抽提物的混合物是有利的。优选本发明的黄酮类化合物分别含有至少40％黄酮醇类和至少10％花色素类，更优选分别含有至少60％和至少15％。优选不含有如儿茶素、原花色素(proanthocyanidins)和其它鞣酸，即小于黄酮类化合物总量的3％。
本发明组合物的目的在于改善血液循环，加快愈合并增强免疫力，补偿疾病期间损失的营养组分。该组合物还稳定了细胞膜对抗意外的攻击。除了生育酚和抗坏血酸盐，谷胱甘肽和NADPH也可增强该功能，谷胱甘肽和NADPH可通过注入蛋氨酸、辅因子和能量(碳水化合物)而得到。
另外优选的化合物为维生素B6(吡哆醛)、B12(氰钴胺)和叶酸，每种含量均为约推荐的平均日摄入量(如RDA)的三倍。维生素B1(硫胺素)和B2(核黄素)、铜、锌和锰分别优选为两倍于RDA的量添加。锌和铜的比率优选为7-14，特别是8-11。铁、钴、碘、铬、硒、氟、钼和泛酸、维生素A(以维生素A等同物，RE)、维生素D、维生素K、烟酸(以烟酸等同物NE)、维生素H和肌醇分别优选以0.5-4倍于，特别是两倍于RDA值的量添加。无机物优选按下述数值添加(每日用量)：钠200-1200毫克、氯化物240-1400毫克、钾500-1800毫克、钙500-1000毫克、磷400-900毫克以及镁150-400毫克。
类胡萝卜素(为达到本发明的目的，包括植物黄质和叶黄素)优选以0.8-16毫克/天，优选1-6毫克/天添加。类胡萝卜素以天然形式使用较有利，如从植物如西红柿、胡椒、金盏花和油棕的果实的抽提物中得到的。优选将这种抽提物混合，且该混合物可含有如黄体素(20-60％)、番茄红素(1-30％)、α-胡萝卜素(5-25％)、β-胡萝卜素(5-40％)、隐黄质(1-15％)和玉米黄质(1-15％)。
胆碱或其代谢等同物如甜菜碱或磷脂酰胆碱优选以20-3000毫克/天添加，其可含有如1克或更多的磷脂酰胆碱。肉毒碱、肌酸和牛磺酸可分别以每天10-100毫克、100-1000毫克和10-100毫克存在。
作为本发明的组合物的一个具体例子，可以含有50-100克/升蛋白质，60-180克/升碳水化合物和20-40克/升脂肪，该脂肪含有0.05-0.5克/升DHA。ω-3系列的长链不饱和脂肪酸的，特别是EPA和DHA的存在也是有利的。EPA和DHA的总量介于0.1-1.0克/天是有利的。长链不饱和脂肪酸中ω-6/ω-3的比率介于1-6，优选介于2-5。也可含有亚油酸(ω-6)，优选为至少0.1克/天。
本发明组合物其它有利的组分为食用纤维质，其可包括可溶性非淀粉多糖如***胶或果胶；不溶性非淀粉多糖如纤维素、半纤维素和木素；低聚糖如菊粉或半乳低聚糖和/或稳定的淀粉。优选食用纤维质的用量为3-20克/天或3-120克/升。
碳水化合物、调味品和酵母抽提物还可增强所述组合物的营养和感官性。产物优选以避免氧气和光，特别是紫外线的形式，以100-1000毫升为单位进行封装。较小的剂量适用作食品添加剂，而较大的剂量适用作完全食物如肠内应用。
重要组分精氨酸、维生素C和维生素E的量也可以单位能量含量(1000千卡)或单位体积(1升)定义。相似的定义可给予优选的组分，如黄酮类化合物(16-60毫克/1000千卡，16-80毫克/升)，类胡萝卜素(1.6-20毫克/1000千卡，1.6-24毫克/升)、锌(18-60毫克/1000千卡，18-75毫克/升)和铜(2.5-10毫克/1000千卡，2.5-12毫克/升)。
本发明的组合物在其日剂量中还可以含有选自于0.8-5克(优选1-3克)蛋氨酸，0.4-1.2毫克叶酸，4-10毫克维生素B6和2-20微克维生素B12中的至少一种。
本发明的组合物每1000毫升中还可以含有选自于0.2-1.5毫克维生素A1等同物，8-20毫克维生素D，2-5毫克维生素B1，1.7-5毫克维生素B2，80-200毫克胆碱等同物，6-24毫克泛酸，50-500微克维生素H，4-20毫克锰，5-20毫克铁和70-140微克硒中的至少一种。
本发明的组合物可以每1000千卡能量含有：6-18克精氨酸，400-1500毫克抗坏血酸等同物、100-500毫克α-生育酚等同物和18-60毫克锌。
本发明的组合物可以每升含有：6-20克精氨酸，400-1800毫克抗坏血酸等同物、100-600毫克α-生育酚等同物和18-75毫克锌。
本发明的组合物每毫升含有0.9-1.3千卡的能量，即含有0.9-1.3千卡/毫升的能量。
综上所述，表1列出了组合物的推荐和优选的范围，以及可以液体组合物形式使用的配方的实施例，该组合物可提供每天最小需求的营养物质的总量，并可用所需的能量进行补充。
                                    表1
营养素 单位 推荐日用量*  用量范围(每天) 优选用量范围(每天)   实施例II饮用辅助组合物(400毫升/天)     实施例I管饲法辅助组合物(1升/天)
    能量 千卡     300-1300     500     1000
   蛋白质碳水化合物脂肪  克克克     25-9040-1605-36     405614     6412627
   精氨酸蛋氨酸抗坏血酸生育酚(TE)黄酮类化合物  克克毫克毫克毫克 50-608-10  3-150.8-5180-84050-4008-40     5-101-3300-70080-25010-30     60.950020023 1.853020023
维生素A(RE)维生素B1维生素B2维生素B6维生素B12维生素D叶酸泛酸维生素H维生素K1烟酸(NE)肉碱肌醇月桂精胆碱(等同物)类胡萝卜素镁锌铁铜钴锰碘硒铬钼氟化物氯化物钠钾钙磷 微克毫克毫克毫克微克微克微克毫克微克微克毫克毫克毫克毫克毫克毫克毫克毫克毫克毫克微克毫克微克微克微克微克毫克毫克毫克毫克毫克毫克   800-10001.1-1.51.3-1.81.4-225-10150-2004-730-10045-8012-20270-40012-1510-151-32-515040-7050-20075-2501.5-4800-1200800-1200  200-15001-91-104-252-1001-40300-20004-4040-80020-2406-8010-10010-2504-10020-30000.8-1680-6008-805-601-120-101-3025-50035-30010-10035-3000.5-16180-2000120-2400200-2000300-1500200-1400     400-12002-51.7-55-102.5-208-20400-12006-2450-50050-12035-7510-4020-2508-4080-10001-8150-40014-455-202-101-62-2050-25050-25015-7540-2000.5-2.5240-1500200-1200500-1800500-1000400-900     5003.03.06.03.010600876565115501510041602283.038.010010033800.6350250800820720     9003.63.76.84.2136801013660641550151000436036143.939.8160126541602.0130010001500650500
*标准推荐日用量，如RDA
实施例I
在一罐中将表1中所列的成分混合，其用量为表1中最后一列所示量的1000倍。用本领域已知的方法均匀化，并使总体积达到1000升。混合物封装在500毫升瓶中，用作管饲法。
实施例II
在一罐中将表1中所列的成分混合，其用量为表1中第6列所示量的1000倍。用本领域已知的方法均匀化，并使总体积达到400升。将混合物封装在200毫升纸盒中。
实施例III
将下列成分：钠600克、氯化物900克、生育酚150克、胆碱800克，不加黄酮类化合物和类胡萝卜素，以及其它组分按表1中第6列所示量的1000倍进行混合，并如实施例II中所述进行封装。产物为白色的饮品，特别适用于在损失大量无机物后，如在慢性开口伤口的情况下治疗褥疮。

Claims (15)

1、一种适用于治疗压迫溃疡的营养辅助组合物，其含有蛋白质、碳水化合物和脂肪，且其日剂量中含有：3-15克精氨酸或其等同物，180-840毫克抗坏血酸等同物，50-400毫克α-生育酚等同物，且还含有：0.8-16毫克类胡萝卜素、无机物和/或8-40毫克黄酮类化合物，所述无机物添加量为：钠120-2400毫克、氯化物180-2000毫克、钾200-2000毫克、钙300-1500毫克、磷200-1400毫克以及镁80-600毫克。
2、如权利要求1所述的组合物，其日剂量中含有5-10毫克精氨酸或其等同物。
3、如权利要求1所述的组合物，其日剂量中含有300-700毫克抗坏血酸等同物。
4、如权利要求1所述的组合物，其日剂量中含有80-250毫克生育酚等同物。
5、如权利要求1所述的组合物，其日剂量中还含有14-45毫克锌。
6、如权利要求1所述的组合物，其日剂量含有10-30毫克的黄酮类化合物。
7、如权利要求1所述的组合物，其日剂量中还含有14-45毫克锌，和2-10毫克铜，其中锌和铜的比率为7-14。
8、如权利要求1所述的组合物，其中类胡萝卜素含有20-60％的黄体素、1-30％的番茄红素、5-25％的α-胡萝卜素、5-40％的β-胡萝卜素、1-15％的隐黄质和1-15％的玉米黄质。
9、如权利要求1所述的组合物，其日剂量中还含有选自于0.8-5克蛋氨酸，0.3-2毫克叶酸，4-25毫克维生素B6和2-100微克维生素B12的至少一种。
10、如权利要求1所述的组合物，其每1000毫升中还含有选自于0.2-1.5毫克维生素A1等同物，8-20毫克维生素D，2-5毫克维生素B1，1.7-5毫克维生素B2，80-200毫克胆碱等同物，6-24毫克泛酸，50-500微克维生素H，4-20毫克锰，5-20毫克铁和70-140微克硒中的至少一种。
11、如权利要求1所述的组合物，其中所述无机物添加量为：钠200-1200毫克、氯化物240-1400毫克、钾500-1800毫克、钙500-1000毫克、磷400-900毫克以及镁150-400毫克。
12、如权利要求1所述的组合物，含有50-100克/升蛋白质，60-180克/升碳水化合物和20-40克/升脂肪，该脂肪含有0.05-0.5克/升DHA，且其ω-6/ω-3比率为2-5。
13、如权利要求1所述的组合物，其每1000千卡能量含有：6-18克精氨酸，400-1500毫克抗坏血酸等同物、100-500毫克α-生育酚等同物和18-60毫克锌。
14、如权利要求1所述的组合物，其每升含有：6-20克精氨酸、400-1800毫克抗坏血酸等同物、100-600毫克α-生育酚等同物和18-75毫克锌。
15、如权利要求1所述的组合物，其含有0.9-1.3千卡/毫升的能量。
CNB998008508A 1998-05-12 1999-05-12 治疗压迫溃疡的营养组合物 Expired - Lifetime CN1167358C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98201576.0 1998-05-12
EP98201576A EP0960572A1 (en) 1998-05-12 1998-05-12 Nutritional composition for the treatment of pressure ulcers

Publications (2)

Publication Number Publication Date
CN1272043A CN1272043A (zh) 2000-11-01
CN1167358C true CN1167358C (zh) 2004-09-22

Family

ID=8233719

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998008508A Expired - Lifetime CN1167358C (zh) 1998-05-12 1999-05-12 治疗压迫溃疡的营养组合物

Country Status (18)

Country Link
US (3) US6846494B1 (zh)
EP (3) EP0960572A1 (zh)
JP (1) JP2002514574A (zh)
CN (1) CN1167358C (zh)
AT (1) ATE516715T1 (zh)
AU (1) AU753543B2 (zh)
BR (1) BR9906438A (zh)
CA (1) CA2296669C (zh)
CZ (1) CZ292240B6 (zh)
ES (1) ES2369970T3 (zh)
HU (1) HU229066B1 (zh)
ID (1) ID24710A (zh)
NO (1) NO318672B1 (zh)
NZ (1) NZ502235A (zh)
PL (1) PL194179B1 (zh)
PT (2) PT1018896E (zh)
TR (1) TR200000077T1 (zh)
WO (1) WO1999058000A1 (zh)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960572A1 (en) * 1998-05-12 1999-12-01 N.V. Nutricia Nutritional composition for the treatment of pressure ulcers
IT1302863B1 (it) * 1998-11-13 2000-10-10 Sigma Tau Healthscience Spa Composizione ad attivita' antiossidante e preventiva di alterazionitrombotiche e aterosclerotiche comprendente una carnitina ed un
GB0101459D0 (en) * 2001-01-19 2001-03-07 Uni Vite Exp Ltd Nutritional composition
GB2374514A (en) * 2001-04-20 2002-10-23 Nakajima Suisan Bio & Techno C Fish feed
NL1019368C2 (nl) * 2001-11-14 2003-05-20 Nutricia Nv Preparaat voor het verbeteren van receptorwerking.
WO2003075935A1 (fr) * 2002-03-11 2003-09-18 Eisai Co., Ltd. Medicaments contenant des composes du type riboflavine
US6562378B1 (en) * 2002-08-16 2003-05-13 Tsar Health Private Ltd. Nutritional supplement for adolescents
US6565891B1 (en) * 2002-08-23 2003-05-20 Tsar Health Private Ltd. Nutritional supplement for children
GB2396809A (en) * 2003-01-03 2004-07-07 Vitabiotics Ltd Composition for the treatment of HIV and AIDS
US20070042019A1 (en) * 2003-05-22 2007-02-22 N.V. Nutricia Method of treating or preventing chronic wounds and a complete nutritional composition comprising glycine and/or leucine for use therein
FR2858181B1 (fr) * 2003-07-30 2008-02-29 Christian Fenioux Preparation alimentaire hyperproteinee comportant au moins un polyphenol
ES2314485T3 (es) * 2003-12-24 2009-03-16 N.V. Nutricia Composiciones que comprenden acido pantotenico o derivados del mismo y su uso para estimular el apetito.
KR101075816B1 (ko) 2004-09-22 2011-10-25 아지노모토 가부시키가이샤 종합 경장 영양 조성물
DE102005001645A1 (de) * 2005-01-13 2006-07-20 Gerhard Dr. Sauermann Topisches Produkt zur Vorbeugung und Behandlung von Windeldermatitis
DE102005012060A1 (de) * 2005-03-16 2006-09-21 Gerhard Dr. Sauermann Orales Produkt zur Vorbeugung und Behandlung von Windeldermatitis
US7879374B2 (en) * 2005-07-22 2011-02-01 Cellutions, LLC Composition including superoxide dismutase and prickly-pear cactus for minimizing and preventing hangovers
EP2368442B1 (en) 2005-07-27 2014-12-17 Symrise AG Use of hesperetin for enhancing the sweet taste
WO2007089267A1 (en) 2006-02-03 2007-08-09 Jr Chem, Llc Anti-aging treatment using copper and zinc compositions
US7897800B2 (en) 2006-02-03 2011-03-01 Jr Chem, Llc Chemical compositions and methods of making them
US7687650B2 (en) 2006-02-03 2010-03-30 Jr Chem, Llc Chemical compositions and methods of making them
EP1986566B1 (en) * 2006-02-17 2011-11-30 Viridis Pharmaceutical Limited Accelerating agent of calcium absorption
US7867522B2 (en) 2006-09-28 2011-01-11 Jr Chem, Llc Method of wound/burn healing using copper-zinc compositions
JP2008253148A (ja) * 2007-03-30 2008-10-23 Naris Cosmetics Co Ltd 冷え性改善機能を有する食品組成物
US20090118228A1 (en) * 2007-11-07 2009-05-07 Bristol-Myers Squibb Company Carotenoid-containing compositions and methods
US8273791B2 (en) 2008-01-04 2012-09-25 Jr Chem, Llc Compositions, kits and regimens for the treatment of skin, especially décolletage
CN102847153B (zh) * 2008-01-10 2015-03-11 营养株式会社 用于改善高龄者的营养状态、降低发热次数和/或提高免疫能力的组合物
IT1392084B1 (it) * 2008-12-12 2012-02-09 Marzullo Composizione immuno-nutrizionale
CA2750636C (en) 2009-01-23 2017-07-25 Jr Chem, Llc Rosacea treatments and kits for performing them
ITBO20090070A1 (it) * 2009-02-12 2010-08-12 Monica Bonucci Farmaco per la stomatite aftosa
FR2963725B1 (fr) * 2010-08-16 2013-01-18 Holymark Composition alimentaire pour prevenir et limiter la perte de masse musculaire, la perte de densite minerale osseuse et le declin cognitif, en particulier chez les personnes agees de 50 ans et plus
CN102464897A (zh) * 2010-11-11 2012-05-23 卢卫红 一种具有抗辐射作用的玉米色素组分配方
US8952057B2 (en) 2011-01-11 2015-02-10 Jr Chem, Llc Compositions for anorectal use and methods for treating anorectal disorders
WO2014071176A1 (en) * 2012-11-02 2014-05-08 Disilvestro Robert Nutritional supplements including meal replacements and related methods
US10835543B2 (en) * 2013-05-31 2020-11-17 Sports Nutrition Research, Ltd. Method of increasing muscle mass and strength and compositions therefor
FR3031676B1 (fr) * 2015-01-16 2018-04-27 Nutricos Technologies Composition cosmetique pour administration par voie orale pour renforcer la barriere cutanee.
JP2018510129A (ja) * 2015-02-13 2018-04-12 ネステク ソシエテ アノニム 手術によって誘発される悪液質並びに／又は骨髄由来サプレッサー細胞及び炎症性サイトカインの発現の処置又は予防
JP6634397B2 (ja) * 2016-02-10 2020-01-22 花王株式会社 容器詰飲料
CA3051366A1 (en) * 2017-01-24 2018-08-02 Jesus LEAL N-acetyle cysteine based compositions
TWI761672B (zh) 2018-04-23 2022-04-21 日商阿爾卑斯藥品工業股份有限公司 O-醣苷基類黃酮之組成物
AU2019345982A1 (en) 2018-09-25 2021-05-06 Roquette Freres Food composition containing a mixture of leguminous proteins and casein
DE102018124227A1 (de) 2018-10-01 2020-04-02 sanaFactur GmbH Zubereitung zur Verbesserung körpereigener Wundheilung
US10918654B1 (en) * 2019-09-23 2021-02-16 Alps Pharmaceutical Ind. Co., Ltd. Rutin compositions

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5053387A (en) * 1987-02-20 1991-10-01 Shriners Hospitals For Crippled Children Omega-3 fatty acids in traumatic injury treatment
EP0367724B1 (en) * 1988-10-31 1993-02-10 Sandoz Nutrition Ltd. Improvements in or relating to organic compounds
CA2123678A1 (en) * 1991-11-26 1993-06-10 Alain Martin Wound healing compositions containing a pyruvate, an antioxidant and a mixture of fatty acids
US5221668A (en) * 1992-02-26 1993-06-22 Abbott Laboratories Nutritional product for trauma and surgery patients
AU3374593A (en) 1992-04-10 1994-04-14 Clintec Nutrition Company Improved high protein liquid nutrition for patients with elevated wound healing requirements
GB2274235B (en) * 1993-01-13 1996-06-26 Neo Life Company Of America Carotenoid food supplement
GB9318611D0 (en) * 1993-09-08 1993-10-27 Sandoz Nutrition Ltd Improvements in or relating to organic compounds
GB9403935D0 (en) * 1994-03-01 1994-04-20 Sandoz Nutrition Ltd Improvements in or relating to organic compounds
US5656588A (en) * 1994-07-19 1997-08-12 Wake Forest University Wound healing formula
US6190704B1 (en) 1994-09-23 2001-02-20 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Regulation of wound healing by nitric oxide
US5733884A (en) * 1995-11-07 1998-03-31 Nestec Ltd. Enteral formulation designed for optimized wound healing
US6139872A (en) * 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
DE69826253D1 (de) * 1997-03-20 2004-10-21 Coventry Group Ltd Nährungsergänzungsmittel für kardiovasküläre gesundheit
US5968896A (en) * 1998-01-16 1999-10-19 Beth Israel Deaconess Medical Center Nutritional supplement for preoperative feeding
EP0960572A1 (en) * 1998-05-12 1999-12-01 N.V. Nutricia Nutritional composition for the treatment of pressure ulcers

Also Published As

Publication number Publication date
PL194179B1 (pl) 2007-05-31
BR9906438A (pt) 2000-07-11
NO20000128D0 (no) 2000-01-10
EP0960572A1 (en) 1999-12-01
US8163303B2 (en) 2012-04-24
ES2369970T3 (es) 2011-12-09
US6846494B1 (en) 2005-01-25
CA2296669A1 (en) 1999-11-18
US20080020062A1 (en) 2008-01-24
WO1999058000A1 (en) 1999-11-18
US7695732B2 (en) 2010-04-13
TR200000077T1 (tr) 2000-11-21
CN1272043A (zh) 2000-11-01
EP2277394A1 (en) 2011-01-26
CZ2000108A3 (cs) 2000-12-13
CZ292240B6 (cs) 2003-08-13
AU753543B2 (en) 2002-10-24
EP1018896B1 (en) 2011-07-20
ATE516715T1 (de) 2011-08-15
EP1018896A1 (en) 2000-07-19
HU229066B1 (en) 2013-07-29
HUP0003265A3 (en) 2001-03-28
PL338034A1 (en) 2000-09-25
AU3960499A (en) 1999-11-29
CA2296669C (en) 2009-01-27
PT1018896E (pt) 2011-10-13
NO318672B1 (no) 2005-04-25
EP2277394B1 (en) 2014-04-23
NZ502235A (en) 2001-11-30
PT2277394E (pt) 2014-07-11
US20050136129A1 (en) 2005-06-23
JP2002514574A (ja) 2002-05-21
HUP0003265A2 (hu) 2001-02-28
NO20000128L (no) 2000-03-09
ID24710A (id) 2000-08-03

Similar Documents

Publication Publication Date Title
CN1167358C (zh) 治疗压迫溃疡的营养组合物
KR101464500B1 (ko) 흡수 및 생물학적 이용 증진을 위한 완전 천연 종합 비타민및 종합 미네랄 건강 보조제
US20080131561A1 (en) Formulation of supplemented carrageenan jelly and manufacturing process
WO2007076416A2 (en) Composition and methods for inhibiting the progression macular degeneration and promoting healthy vision
US20210353578A1 (en) Dietary macro/micronutritional supplement for patients undergoing kidney dialysis
WO2018039297A1 (en) Dietary macro/micronutritional supplement for patients undergoing kidney dialysis
JP2006104147A (ja) 経口・経腸栄養組成物
CN1739497A (zh) 儿茶素双层微胶囊制备方法
WO2023076572A1 (en) Nutritional composition for glucose support
BG4394U1 (bg) Енергизиращ плодов шейк с горски плодове
CN1559570A (zh) 天然营养液及其制备方法
CN1316243A (zh) 茶多酚及其氧化物治疗贫血症的新用途
CN1374104A (zh) 精制刺玫果营养胶囊

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
CI01 Publication of corrected invention patent application

Correction item: Inventor

Correct: Hoyle Maria Anna Phil Cote

False: Hoyle Maria Anna Phil Cote

Number: 38

Page: 410

Volume: 20

CI03 Correction of invention patent

Correction item: Inventor

Correct: Hoyle Maria Anna Phil Cote

False: Hoyle Maria Anna Phil Cote

Number: 38

Page: The title page

Volume: 20

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: MARIA ANNA VERHEUL-KOOT TO: QIAOKESI MATTHEW

ERR Gazette correction

Free format text: CORRECT: INVENTOR; FROM: MARIA ANNA VERHEUL-KOOT TO: QIAOKESI MATTHEW

CX01 Expiry of patent term

Granted publication date: 20040922

CX01 Expiry of patent term