CN116712158B - Multi-mode physical field tumor ablation treatment system - Google Patents
Multi-mode physical field tumor ablation treatment system Download PDFInfo
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Abstract
The invention provides a multimode physical field tumor ablation treatment system, which comprises: the device comprises a microwave energy module, a radio frequency energy module, a pulse energy module, a freezing energy module, an interface management module and a composite accessory interface; the interface management module is connected with the composite accessory interface, the composite accessory interface is connected with a single accessory or a composite accessory, the single accessory comprises a single accessory corresponding to any one of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module, and the composite accessory comprises composite accessories corresponding to more than two of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module. The invention realizes the fusion and integration technology of the multi-energy platform and realizes the output of multiple energies through the same accessory.
Description
Technical Field
The invention relates to the technical field of tumor ablation, in particular to a multi-mode physical field tumor ablation treatment system.
Background
The idea of Ablation is Ablation, the concept of Ablation is introduced mainly to distinguish from surgical Ablation. Tumor ablation (tumor ablation) is an accurate, minimally invasive interventional technique that is guided by modern imaging techniques (e.g., ultrasound, CT, MRI, etc.), applied to focal solid tumor(s) using chemical or physical methods, to directly eradicate or destroy tumor tissue, and to achieve the effect of "ablating" the tumor, including chemical ablation (chemical ablation) and energy ablation (ablation-based ablation).
When the current radio frequency ablation equipment, the microwave ablation equipment, the cryoablation equipment and the pulse ablation equipment are relatively independent, and are used by clinical users, different treatment equipment is required to be selected according to treatment requirements. While the independent treatment equipment of a plurality of different technologies is arranged in an operating room, the complexity is increased for the originally compact operating room; the clinical users cannot realize unified coordination when using the medical device to exert the respective technical treatment advantages; the synergistic composite ablation can not be effectively performed so as to achieve the synergistic therapeutic effect of the composite ablation.
Disclosure of Invention
The invention aims at the problems and provides a multi-mode physical field tumor ablation treatment system.
The multi-modal physical field tumor ablation treatment system of the present invention comprises: the device comprises a microwave energy module, a radio frequency energy module, a pulse energy module, a freezing energy module, an interface management module and a composite accessory interface for connecting the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module;
the interface management module is connected with the composite accessory interface, the composite accessory interface is connected with a single accessory or a composite accessory, the single accessory comprises a single accessory corresponding to any one of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module, and the composite accessory comprises composite accessories corresponding to more than two of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module.
In some implementations, the interface management module includes:
the first isolation module is connected between the microwave energy module and the composite accessory interface and is used for enabling microwave energy signals sent by the microwave energy module to pass through and blocking radio frequency energy signals sent by the radio frequency energy module and/or pulse energy signals sent by the pulse energy module;
The first impedance/interface converter is connected between the radio frequency energy module and the composite accessory interface and is used for converting the impedance of the pulse energy signal sent by the radio frequency energy module into the same impedance as the microwave energy signal sent by the microwave energy module;
the second impedance/interface converter is connected between the pulse energy module and the composite accessory interface and is used for converting the impedance of the pulse energy signal sent by the pulse energy module into the same impedance as the impedance of the microwave energy signal sent by the microwave energy module;
the refrigerant/heating regulation and control assembly is connected between the freezing energy module and the composite accessory interface and is used for regulating and controlling freezing operation and rewarming operation.
In some implementations, the system of the present invention further comprises: the independent accessory interface comprises a microwave interface, a radio frequency interface, a pulse interface and a freezing interface, and is used for being connected with a single accessory to realize the output of corresponding single energy or connected with a composite accessory to realize the output of single energy.
In some implementations, the system of the present invention further comprises:
the first radio frequency energy module switch is connected between the radio frequency energy module and the first impedance/interface converter and used for switching radio frequency energy to the first impedance/interface converter;
The first pulse energy module switch is connected between the pulse energy module and the second impedance/interface converter and used for switching pulse energy to the second impedance/interface converter;
the first refrigeration medium/heating medium switch is connected between the refrigeration energy module and the refrigerant/heating regulation and control assembly and is used for controlling the refrigeration medium or the heating medium to the refrigerant/heating regulation and control assembly.
In some implementations, the system of the present invention further comprises:
the microwave module switch is connected between the isolation module and the composite accessory interface and is positioned between the isolation module and the microwave interface and used for distributing microwave energy to the composite accessory interface or the independent accessory interface;
the second radio frequency energy module switch is connected between the radio frequency energy module and the radio frequency interface and used for distributing radio frequency energy to the radio frequency interface of the independent accessory interface;
the second pulse energy module switch is connected between the pulse energy module and the pulse interface and used for distributing pulse energy to the pulse interface of the independent accessory interface;
the second refrigeration medium/heating medium switch is connected between the refrigeration energy module and the refrigerant/heating regulation and control assembly and is used for controlling the connection of the refrigeration medium or the heating medium to the refrigeration interface of the refrigerant/heating regulation and control assembly and the independent accessory interface.
In some implementations, the system of the present invention further comprises: the multi-channel switcher is connected to the front end of the composite accessory interface and is used for realizing the coupling connection between the energy signals output by the energy modules and the composite accessory interface, and one energy signal is selected to be output to the composite accessory interface at any moment.
In some implementations, the first impedance/interface converter or the second impedance/interface converter employs an impedance conversion circuit or an impedance conversion structure.
In some implementations, the impedance transformation circuit is in the form of a microstrip circuit, and the impedance transformation structure is in the form of a coaxial structure; under the condition that the radio frequency energy signal or the pulse energy signal works in a set low-frequency state, the first impedance/interface converter or the second impedance/interface converter adopts a microstrip circuit form or a coaxial structure form;
the first impedance/interface converter or the second impedance/interface converter comprises an impedance converter and an impedance interface 320, the impedance converter comprises a first outer insulator, a first conductor, a first medium and a second conductor, and the impedance interface comprises a second outer insulator, a third conductor, a second medium and a fourth conductor;
the first conductor is arranged outside the second conductor, the first medium is arranged between the first conductor and the second conductor, and the first outer insulator is arranged outside the first conductor; the third conductor is arranged outside the fourth conductor, the second medium is arranged between the third conductor and the fourth conductor, and the second outer insulator is arranged at the joint of the impedance converter and the impedance interface and is integrated with the first outer insulator; the second medium ring completely wraps the fourth conductor, the length of the front end of the second medium exceeds that of the fourth conductor, and the set length or the set width is kept, so that enough electric gap and creepage distance between the fourth conductor and the third conductor are ensured.
In some implementations, the impedance conversion circuit is in the form of a microstrip circuit with impedance steps or impedance gradients, and the impedance conversion structure is in the form of a coaxial structure with impedance steps or impedance gradients; under the condition that the radio frequency energy signal or the pulse energy signal works in a set high-frequency state, the first impedance/interface converter or the second impedance/interface converter adopts a microstrip circuit form with impedance steps or impedance gradual changes or a microstrip circuit form with impedance steps or impedance gradual changes;
the first impedance/interface converter or the second impedance/interface converter comprises an impedance converter and an impedance interface, the impedance converter comprises a first outer insulator, a first conductor, a first medium and a second conductor, and the impedance interface comprises a second outer insulator, a third conductor, a second medium and a fourth conductor;
the first conductor is arranged outside the second conductor, the first medium is arranged between the first conductor and the second conductor, and the first outer insulator is arranged outside the first conductor; the third conductor is arranged outside the fourth conductor, the second medium is arranged between the third conductor and the fourth conductor, and the second outer insulator is arranged at the joint of the impedance converter and the impedance interface and is integrated with the first outer insulator;
The second conductor adopts a multi-section or multi-section structure, so that the impedance of the radio frequency energy signal or the impedance of the pulse energy signal is gradually converted into the same impedance as the impedance of the microwave energy signal sent by the microwave energy module, and the inner diameter or width of the first conductor and the size of the first medium are changed along with the outer diameter or width of the second conductor; the second medium ring completely wraps the fourth conductor, the length of the front end of the second medium exceeds the length of the fourth conductor, and the set length or the set width is kept, so that enough electric gap and creepage distance between the fourth conductor and the third conductor are ensured.
In some implementations, the refrigerant/heating regulation assembly includes an electrical heating assembly, first and second switches, a first safety valve, a second safety valve, a first pressure gauge, a second pressure gauge, a first regulating valve, and a second regulating valve;
the first safety valve, the first pressure gauge and the first regulating valve are sequentially connected, the second safety valve, the second pressure gauge and the second regulating valve are sequentially connected, and the first switch, the electric heating component and the second switch are sequentially connected;
the heating medium is heated by adopting an electric heating mode or a fluid/gas medium heating mode;
in the case of adopting an electric heating mode, the first switch and the second switch are used for isolating and controlling the input and output of the electric heating component in the electric heating mode, and the electric heating component is used as an electric heating energy and control component;
Under the condition of adopting a fluid/gas medium heating mode, the heating medium is output through a first safety valve, a first pressure valve and a first regulating valve, wherein the first safety valve is used for controlling the maximum pressure of the input heating medium, the first pressure gauge is used for monitoring the pressure value of the heating channel, and the first regulating valve is used for regulating the flow or the pressure of the output heating medium; the refrigerating medium is output through a second safety valve, a second pressure gauge and a second regulating valve, wherein the second safety valve is used for controlling the maximum pressure of the input refrigerating medium, the second pressure gauge is used for monitoring the pressure value of the cooling passage, and the second regulating valve is used for regulating the flow or the pressure of the output cooling medium.
In some implementations, the microwave energy signal, the radio frequency energy signal, the pulse energy signal, and the freeze energy signal can be connected to the composite accessory interface through the same electrical path, and the multi-channel switch is configured to select one of the microwave energy signal, the radio frequency energy signal, the pulse energy signal, and the freeze energy signal at any time and output the selected one of the microwave energy signal, the radio frequency energy signal, the pulse energy signal, and the freeze energy signal to the composite accessory interface through the electrical path, and the multi-channel switch includes:
the second isolation module is used for enabling the microwave energy signal sent by the microwave energy module to pass through and blocking the radio frequency energy signal sent by the radio frequency energy module and/or the pulse energy signal sent by the pulse energy module;
The radio frequency energy switch and the pulse energy switch are respectively used for controlling the passing of the radio frequency energy signal and the pulse energy signal;
the heating energy switch is turned off and the refrigerating and heating energy switch is turned on when the heating medium is a fluid medium or a gas medium; when the heating medium is an electric medium, the heating energy switch is turned on, and the refrigerating and heating energy switch is turned off, so that the selection of different heating modes is realized.
In some implementations, the system of the present invention further includes a cooling module for providing a flowing liquid for cooling having a preset pressure to an attachment of at least one of the microwave energy module, the radio frequency energy module, and the pulse energy module.
In some implementations, the system of the present invention further includes a thermometry module for measuring a temperature of an attachment of at least one of the microwave energy module, the radio frequency energy module, the pulse energy module, or for measuring a temperature of a target tissue for ablation treatment with the at least one of the microwave energy module, the radio frequency energy module, the pulse energy module.
In some implementations, the system of the present invention further comprises:
The man-machine interaction module is used as a man-machine interaction interface to realize the input and display of user instructions and related parameters;
the main control module is connected with the man-machine interaction module, the microwave energy module, the radio frequency energy module, the pulse energy module, the freezing energy module, the interface management module and the composite accessory interface and used for processing related data of the man-machine interaction module and monitoring and controlling states of all the modules.
In some implementations, the system of the present invention further includes an ECG module, coupled to the master control module, for acquiring and transmitting human electrocardiogram signals.
The invention has at least the following beneficial effects:
the multi-mode physical field tumor ablation treatment system realizes the fusion and integration technology of the multi-energy platform, the energy required by the multi-mode physical field tumor ablation technology is realized in the same equipment, the connection of the composite accessory can be realized, the output of various energies through the same accessory can be realized, the independent accessory can be also connected, the output of corresponding energy is realized, and the energy output can be freely configured. The multiple ablation technologies are integrated on the same system platform, the occupied space is small, the utilization rate of compact space of an operating room is obviously improved, in addition, users do not need to use products of different brands or different platforms, the identity is good, the user acceptability is good, and learning curves can be reduced.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be considered as limiting the scope.
FIG. 1 is a block diagram of a multi-modal physical field tumor ablation therapy system provided by an embodiment of the present invention;
FIG. 2 is a block diagram of an interface management module provided by an embodiment of the present invention;
fig. 3 is a schematic diagram of an impedance/interface converter structure and an equivalent circuit according to an embodiment of the present invention;
FIG. 4 is a schematic diagram of another impedance/interface converter structure and equivalent circuit according to an embodiment of the present invention;
FIG. 5 is a block diagram of a refrigerant/heating control assembly according to an embodiment of the present invention;
fig. 6 is a block diagram of a multi-channel switch according to an embodiment of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. The components of the embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the invention, as presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be made by a person skilled in the art without making any inventive effort, are intended to be within the scope of the present invention.
Chemical ablation refers to a treatment method for penetrating tumor through skin by adopting a special needle under the guidance of ultrasound or CT, directly injecting chemical drugs, protein coagulants and the like into the tumor, inactivating tumor cells in situ, and naturally melting and absorbing tumor tissues. In the process, the medicine directly contacts tumor tissue cells, influences the living environment of the tumor cells or interferes the metabolism of the tumor tissue, thereby achieving the purpose of inhibiting the growth of the tumor, and even directly coagulates tumor cell protein and damages the tumor tissue.
Energy ablation requires the assistance of energy supplied by medical instruments to inactivate and melt tumor tissue. According to different working principles, energy ablation can be divided into radio frequency ablation, microwave ablation, cryoablation, pulse energy ablation, ultrasonic ablation, laser ablation and the like.
The radio frequency ablation is mainly characterized in that a radio frequency ablation needle is percutaneously penetrated into tumor tissue by guiding image equipment such as ultrasound, CT, magnetic resonance and the like, a negative plate is attached to the surface of skin, then a power supply is connected, a radio frequency power source sends out a frequency signal, an ablation electrode is connected through a high-frequency cable to be transmitted to a working end, so that a high-frequency electric field is formed in the tissue covered by the electrode, conductive ions and polarized molecules of tissue cells are caused to operate at a high speed to vibrate and rub to generate heat energy, a spherical or ellipsoidal hot area is generated at the front end of the ablation needle, and the generated heat can enable the local temperature of the center to reach 90-120 ℃, so that the tumor cells coagulate and necrose. The radio frequency has a single needle and a claw needle, and the claw needle has a good conformal ablation function.
Cryoablation is a method for inactivating solid tissues in situ by freezing pathological tissues through a low-temperature technology, and the action principle is that the pathological tissues are rapidly cooled by utilizing low temperature to cause ice crystal damage, solute damage and microvascular embolism to cells, so that cell necrosis or apoptosis is caused, and the aim of treatment is fulfilled. Because cryoablation adopts the physical method of energy exchange to achieve the aim of treatment, the injury and side effect of the cryoablation on human bodies are far lower than those of conventional radiotherapy and chemotherapy, and therefore, the cryoablation is known as green therapy by people.
Microwave ablation is a thermal ablation technique that can be applied to tumor treatment. The biological tissue is heated rapidly by microwaves, so that the tumor tissue is heated, denatured and necrotized, and the purpose of treating the tumor is achieved. The mechanism of microwave heating is mainly to make dipoles such as water molecules in tissues generate heat by friction through the action of electromagnetic fields, so that a large amount of heat energy can be rapidly generated in a short time, and the tissues reach high temperature. Compared with other thermal ablation technologies such as radio frequency ablation, laser ablation and the like, the microwave ablation has the characteristics of quick heating, strong blood vessel coagulation capability, small influence by blood flow factors, larger and stable normal coagulation range and the like, and is a technology with good application prospect in thermal ablation treatment technology.
Pulsed electric field (EP) electroporation therapy is divided into reversible electroporation and irreversible electroporation. Reversible electroporation (Reversible electroporation, IRE) is used mainly in electrochemical treatment of tumors, and hydrophilic micropores appear in biological cell membranes under the action of a pulsed electric field, so that the permeability of the cell membranes is enhanced, and when the pulsed electric field is removed, the micropores slowly recover and maintain the cell activity. Electroporation using a pulsed electric field facilitates the absorption of various anticancer drugs, genetic materials, proteins, other macromolecules and liposomes into cells, and thus a so-called electroporation therapy or electrochemical therapy has been developed.
Irreversible electroporation (Irreversible electroporation, IRE) is the only non-thermal minimally invasive tumor ablation technology at present, and a pair of ablation needles penetrating into the tumor through skin generate a short pulse high-voltage electric field, so that permanent nanoscale electroporation is generated on tumor cell membranes, the inside and outside environment of the cell membranes is destroyed, apoptosis necrosis is caused, a mononuclear-macrophage immune system is activated, apoptotic cells are phagocytosed and cleared, and other small lesions or metastatic lesions are also disappeared. Because different tissue cells need different electric field intensities to generate electric transmission holes, irreversible electroporation ablation has the characteristics of rapidness, selectivity, nonthermal property and the like, and has small damage to normal tissues around the disease.
When the current radio frequency ablation equipment, the microwave ablation equipment, the cryoablation equipment and the pulse ablation equipment are relatively independent, and are used by clinical users, different treatment equipment is required to be selected according to treatment requirements. While the independent treatment equipment of a plurality of different technologies is arranged in an operating room, the complexity is increased for the originally compact operating room; the clinical users cannot realize unified coordination when using the medical device to exert the respective technical treatment advantages; the synergistic composite ablation can not be effectively performed so as to achieve the synergistic therapeutic effect of the composite ablation.
In one embodiment of the present invention, there is provided a multi-modal physical field tumor ablation treatment system, as shown in fig. 1, comprising: the device comprises a microwave energy module, a radio frequency energy module, a pulse energy module, a freezing energy module, an interface management module and a composite accessory interface for connecting the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module;
the interface management module is connected with the composite accessory interface, the composite accessory interface is connected with a single accessory or a composite accessory, the single accessory comprises a single accessory corresponding to any one of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module, and the composite accessory comprises composite accessories corresponding to more than two of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module.
The multi-mode physical field tumor ablation treatment system realizes the fusion and integration technology of the multi-energy platform, the energy required by the multi-mode physical field tumor ablation is realized in the same equipment, the connection of the composite accessory can be realized, the output of the various energies through the same accessory can be realized, the independent accessory can also be connected, the output of the corresponding energy is realized, and the energy outputs can be freely configured. The multiple ablation technologies are integrated on the same system platform, the occupied space is small, the utilization rate of compact space of an operating room is obviously improved, in addition, users do not need to use products of different brands or different platforms, the identity is good, the user acceptability is good, and learning curves can be reduced.
It should be understood that the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module are used as energy sources required by ablation and are matched with corresponding accessories, so that corresponding tumor ablation operation can be realized, and cooperative composite ablation can be realized through connecting the composite accessories, so that the cooperative treatment purpose of composite ablation is achieved.
The interface management module can realize the tandem, distribution and interface control of each energy module.
Further, as shown in fig. 2, the interface management module may include:
The first isolation module is connected between the microwave energy module and the composite accessory interface, and is used for enabling the microwave energy signal sent by the microwave energy module to pass through and blocking the radio frequency energy signal sent by the radio frequency energy module and/or the pulse energy signal sent by the pulse energy module. Because the frequency of the microwave energy signal is often higher than that of the radio frequency energy signal and the pulse energy signal, the first isolation module is arranged in the line of the microwave energy signal connected to the composite accessory interface, so that the radio frequency energy signal or the pulse energy signal with low frequency can be effectively isolated from reversely channeling into the microwave energy source, and the high-voltage and low-frequency energy is prevented from damaging the microwave energy source device. The first isolation module may be LC or C isolation, may be in a coaxial manner, or may be in a microstrip manner, and the specific implementation manner of the first isolation module is not limited only in this embodiment.
The first impedance/interface converter is connected between the radio frequency energy module and the composite accessory interface and is used for converting the impedance of the pulse energy signal sent by the radio frequency energy module into the same impedance as the microwave energy signal sent by the microwave energy module;
the second impedance/interface converter is connected between the pulse energy module and the composite accessory interface and is used for converting the impedance of the pulse energy signal sent by the pulse energy module into the same impedance as the impedance of the microwave energy signal sent by the microwave energy module;
The refrigerant/heating regulation and control assembly is connected between the freezing energy module and the composite accessory interface and is used for regulating and controlling freezing operation and rewarming operation.
Further, the first impedance/interface converter and the second impedance/interface converter have the same structure, and the first impedance/interface converter or the second impedance/interface converter may employ an impedance conversion circuit or an impedance conversion structure. The impedance conversion circuit can be in a microstrip circuit form or a strip circuit form, and the impedance conversion structure can be in a coaxial structure form.
The impedance conversion circuit or the impedance conversion structure mainly realizes the most effective transmission of radio frequency energy signals or pulse energy signals and microwave energy signals in the same link, and outputs and finally multiplexes the same composite accessory interface. The interface impedance of the radio frequency energy signal or the pulse energy signal can be converted into a high frequency impedance interface by an impedance conversion circuit or structure.
In some cases, the rf energy signal or the pulse energy signal works in a set low-frequency (working frequency is lower), and at this time, impedance conversion is not needed to be considered, and the link impedance of the rf energy signal or the pulse energy signal is directly designed to be the same as the impedance of the microwave energy signal, i.e. the link is connected with the same impedance, so that the effective transmission of the rf energy signal or the pulse energy signal is not affected, and the most effective transmission of the microwave energy signal is ensured.
The first impedance/interface transformer and the second impedance/interface transformer may take the form of a microstrip circuit or a coaxial structure, as shown in the left diagram of fig. 3, and the first impedance/interface transformer or the second impedance/interface transformer includes an impedance transformer 310 and an impedance interface 320, further, the impedance transformer 310 includes a first outer insulator 311, a first conductor 312, a first medium 313 and a second conductor 314, and the impedance interface 320 includes a second outer insulator 321, a third conductor 322, a second medium 323 and a fourth conductor 324.
The first conductor 312 is disposed outside the second conductor 314, the first medium 313 is disposed between the first conductor 312 and the second conductor 314, and the first outer insulator 311 is disposed outside the first conductor 312; the third conductor 322 is disposed outside the fourth conductor 324, the second medium 323 is disposed between the third conductor 322 and the fourth conductor 324, and the second outer insulator 321 is disposed at the connection portion between the impedance transformer 310 and the impedance interface 320 and is integral with the first outer insulator 311.
In the case of a microstrip circuit, the first outer insulator 311 and the second outer insulator 321 are outer insulators of a reference ground plane, the first conductor 312 and the third conductor 322 are reference ground planes, the first medium 313 and the second medium 323 are microstrip filling mediums, and the second conductor 314 and the fourth conductor 324 are signal transmission lines.
In the case of the coaxial structure, the first outer insulator 311 and the second outer insulator 321 are outer insulators of outer conductors, the first conductor 312 and the third conductor 322 are outer conductors, the first medium 313 and the second medium 323 are intermediate mediums, and the second conductor 314 and the fourth conductor 324 are inner conductors.
The first medium 313 and the second medium 323 are made of, for example, PTFE, polytetrafluoroethylene, ceramics, plastics, PE, or the like, and other medium materials may be used. The present embodiment is not limited in any way.
The equivalent circuit of the impedance/interface converter at low frequency is shown in the right diagram of FIG. 3, and the transmission link of the RF energy signal or the pulse energy signal can be equivalent to a resistor R t And (5) a model.
In other cases, the RF energy signal or the pulse energy signal is operated at a set high frequency (higher frequency, such as above 100 k), and an instantaneous current I is generated between the signal line and the reference plane due to the establishment of an electric field at the place where the signal edge arrives during signal transmission, and if the output level of the signal is V, the signal transmission line is equivalent to a resistor with the voltage of V/I during signal transmission, and the equivalent resistor is called the impedance Z of the signal transmission line 0 In some examples, high frequency impedance interface Z 0 May be 50Ω or 75Ω.
When the rf energy signal or the pulse energy signal operates at a higher frequency, since the impedance of the rf energy signal or the pulse energy signal is considered to be different from the impedance of the microwave energy signal, an effective transition between the signal impedances needs to be considered to ensure that the rf energy signal or the pulse energy signal (the source-impedance transformer 310) and the microwave energy signal (the load-impedance interface 320) are both transmitted effectively. The source impedance of the rf energy signal or the source impedance of the pulsed energy signal is typically 30 Ω to 1000 Ω, while the impedance typically used for the microwave energy signal is 50 Ω or 75 Ω. In this embodiment, an impedance transformation is performed between the two impedances to transform the two to the same impedance, so that the transmission link of each energy signal transmits the signal to the impedance interface 320 more efficiently.
To ensure the source impedance R of the RF or pulse energy signal s And impedance Z of microwave energy signal 0 The wide impedance range between the two is in gentle transition, when the radio frequency energy signal or the pulse energy signal works in a set high frequency state, the impedance conversion circuit adopts a microstrip circuit form with impedance steps or impedance gradual change, and the impedance conversion structure adopts a coaxial structure form with impedance steps or impedance gradual change, namely: the first impedance/interface converter or the second impedance/interface converter takes the form of a microstrip circuit with impedance steps or impedance gradients or a microstrip circuit with impedance steps or impedance gradients.
Microstrip circuit form with impedance step or impedance gradient or microstrip circuit form with impedance step or impedance gradient, and circuit shown in left diagram of figure 3 +.Structurally, the second conductor 314 has a multi-segment or multi-segment structure, so that the impedance of the rf energy signal or the impedance of the pulse energy signal is gradually converted into the same impedance as the microwave energy signal emitted by the microwave energy module (the impedance is gradually changed to the desired target impedance Z) 0 ) The inner diameter or width of the first conductor 312, the size of the first medium 313, varies with the outer diameter or width of the second conductor 314, as shown in the left-hand diagram of fig. 4. In practice, the outer diameter or width of the second conductor 314 is in accordance with the source impedance R s The number of segments of the impedance is cooperatively set by the factors such as the inner diameter of the first conductor 312, the dielectric constant of the medium 313, and the like, and is not specifically exemplified in the present embodiment.
The equivalent circuit of the impedance/interface converter at high frequency is shown in the right diagram of fig. 4, and the transmission link of the radio frequency or pulse energy signal can be equivalent to innumerableR t 、L t 、G t 、C t In a series combination, wherein equivalentR t 、L t AndG t 、C t the position of (c) is not limited, and may be equivalent to any combination of the front and rear positions. By the equivalent distribution parameters, the impedance of each section can be obtained Z t 。
Wherein:R t is equivalent resistance,L t Equivalent inductance,G t Equivalent electrical conductivity,C t The equivalent capacitance of the capacitor is used to determine,jrepresenting the units of an imaginary number,wrepresenting an imaginary number.
Equivalent distribution parameters of the impedance transformer 310, i.e. impedanceZ t Is affected by the inner diameter of the first conductor 312, the dielectric constant of the first medium 313, the outer diameter of the second conductor 314, etc. The first conductor 312 and the second conductor 314 are isolated by a first medium 313 and maintain sufficient electrical clearance and creepage distance, dielectric strength requirements. The outer conductor 312 may be longer than the first medium 313 or shorter than the first medium 313.
Impedance interface 320 is used for implementation and multiplexingThe connection of the accessory interface is different from the conventional radio frequency connector in that the voltage requirement is not high (generally V rms And not exceeding 200V), the second medium 323 of the impedance interface 320 of the present embodiment surrounds and completely wraps the fourth conductor 324, and the length of the front end of the second medium 323 exceeds the fourth conductor 324, and maintains a set length to a set width, for example, the set length is set to a value within the range of 0.5 mm-20 mm, so as to ensure a sufficient electrical gap and creepage distance between the fourth conductor 324 and the third conductor 322, so as to meet the requirement of dielectric strength during radio frequency or steep pulse high voltage composite operation. The third conductor 322 may be longer than the plane of the second medium 323 or shorter than the plane of the second medium 323. The impedance at the interface is consistent with the impedance of the impedance transformer 310. In the case where impedance transformer 310 is in a coaxial configuration, interface 320 may be a coaxial connector, where Z 0 The inner and outer conductor dimensions, the dielectric constant of the filled medium satisfy the following requirements:
Ω
wherein, the liquid crystal display device comprises a liquid crystal display device,indicating the equivalent dielectric constant of the dielectric insulating material,Dindicating the inner diameter of the outer conductor,dindicating the outer diameter of the inner conductor.
Through the design of the impedance converter, the low-frequency signal and the high-frequency signal can be fused with the same transmission link and interface, the same consumable can be supported, different tumor ablation technologies can be completed, and the treatment of different ablation technologies can be realized by one-time puncture, so that the synergistic effect of compound ablation is achieved, the puncture frequency is reduced, and the puncture wound is reduced; by the impedance/interface converter, the channel composite transmission of microwave, radio frequency and pulse energy and the compatibility of different grade voltages are realized.
In some implementations, as shown in fig. 2, the present embodiment further includes: an independent accessory interface;
the independent accessory interface comprises a microwave interface, a radio frequency interface, a pulse interface and a freezing interface, and is used for being connected with a single accessory to realize the output of corresponding single energy or connected with a composite accessory to realize the output of single energy. The energy signals corresponding to the independent accessory interfaces can be independently output in the same period, or at least two groups of energy signals can be simultaneously output for use. The unused energy signals in the composite accessory interface or the independent accessory interface can be used in the respective external interfaces. By configuring the composite accessory interface and the independent accessory interface, the user can conveniently select the composite accessory interface according to clinical treatment requirements, and the multi-technology cooperative treatment is realized; individual treatment techniques may also be selected to achieve the desired treatment.
The multimode physical field tumor ablation treatment system of the embodiment may further include:
the first radio frequency energy module switch S1 is connected between the radio frequency energy module and the first impedance/interface converter and is used for switching radio frequency energy to the first impedance/interface converter;
a first pulse energy module switch S2 connected between the pulse energy module and the second impedance/interface converter for switching pulse energy to the second impedance/interface converter;
the first refrigeration medium/heating medium switch S3 is connected between the refrigeration energy module and the refrigerant/heating regulation and control assembly, and is used for controlling the refrigeration medium or the heating medium to the refrigerant/heating regulation and control assembly.
The multimode physical field tumor ablation treatment system of the embodiment may further include:
the microwave switch is connected between the isolation module and the composite accessory interface and is positioned between the isolation module and the microwave interface and used for distributing microwave energy to the composite accessory interface or the independent accessory interface;
the second radio frequency energy module switch S4 is connected between the radio frequency energy module and the radio frequency interface and used for distributing radio frequency energy to the radio frequency interface;
the second pulse energy module switch S5 is connected between the pulse energy module and the pulse interface and used for distributing pulse energy to the pulse interface;
And the second refrigeration medium/heating medium switch S6 is connected between the refrigeration energy module and the refrigerant/heating regulation and control assembly and is used for controlling the refrigeration medium or the heating medium to the refrigerant/heating regulation and control assembly.
In this embodiment, the microwave switch is configured to distribute microwave energy to the composite accessory interface or the independent accessory interface, with either being selectively gated to achieve either composite accessory interface signaling or independent accessory interface signaling of microwave energy. S1 is used for switching the radio frequency energy signal to a first impedance/interface converter at the rear end of the radio frequency energy signal, S4 is used for distributing the radio frequency energy signal to the independent accessory interface, and the radio frequency energy signal and the independent accessory interface are selected to realize the signal transmission of the radio frequency energy composite accessory interface or the signal transmission of the independent accessory interface. S2 is used for switching the pulse energy signal to the second impedance/interface converter, S5 is used for distributing the pulse energy signal to the independent accessory interface, and the pulse energy signal and the independent accessory interface are alternatively gated so as to realize the composite accessory interface signal transmission or the independent accessory interface signal transmission of the pulse energy. Signal isolation and voltage-resistant isolation among all energy platforms are realized through a multi-switch configuration technology. The switches S1 and S4 may be mechanical relays or solid state isolation switches. The switches S2 and S5 may be high voltage mechanical relays or solid state relays.
As shown in fig. 5, the refrigerant/heating regulation and control assembly includes an electric heating assembly, a first switch S31 and a second switch S32, a first safety valve, a second safety valve, a first pressure gauge, a second pressure gauge, a first regulating valve and a second regulating valve; the first safety valve, the first pressure gauge and the first regulating valve are sequentially connected, the second safety valve, the second pressure gauge and the second regulating valve are sequentially connected, and the first switch S31, the electric heating assembly and the second switch S32 are sequentially connected. The heating medium is heated by an electric heating mode or a fluid/gas medium heating mode.
In the case of adopting the electric heating mode, the paths of the electric heating assembly, the first switch S31 and the second switch S32 are used for isolation and control of the input and output of the electric heating assembly in the electric heating mode, and the electric heating assembly is used as the electric heating energy and control assembly. Wherein the switches S31 and S32 may be mechanical relays or solid-state isolation switches. The pressure gauge can be a pointer pressure gauge or a digital pressure gauge and has a remote transmission function. The regulating valve can be a proportional valve or a flow valve.
In the case of fluid/gaseous medium heating, the heating medium is output via a first relief valve, a first pressure valve and a first regulator valve, the first relief valve being used to control the maximum pressure of the input heating medium to prevent the input pressure from exceeding the maximum withstand pressure of the present assembly or system. The first pressure gauge is used for monitoring the pressure value of the heating passage, and the first regulating valve is used for regulating the flow or pressure of the output heating medium; the second safety valve is used for controlling the maximum pressure of the input refrigeration medium, the second pressure gauge is used for monitoring the pressure value of the cooling passage, and the second regulating valve is used for regulating the flow or the pressure of the output cooling medium.
The refrigeration medium can be carbon dioxide, argon and other gases which are refrigerated in a throttling way, or liquid nitrogen phase-change refrigeration; the heating medium may be a gas or liquid, such as helium or alcohol; and the electric heating mode can be also adopted, such as direct current heating, radio frequency electric heating and the like.
In some implementations, the system of the present embodiment further includes: the multi-channel switcher is connected to the front end of the composite accessory interface and is used for realizing the coupling connection between the energy signals output by the energy modules and the composite accessory interface, and one energy signal is selected to be output to the composite accessory interface at any moment.
The microwave energy signal, the radio frequency energy signal, the pulse energy signal and the freezing energy signal can be connected with the composite accessory interface through the same electrical path, and the multi-channel switcher is used for selecting one of the microwave energy signal, the radio frequency energy signal, the pulse energy signal and the freezing energy signal at any moment and outputting the selected energy signal to the composite accessory interface through the electrical path, as shown in fig. 6, the multi-channel switcher of the embodiment may further include:
the second isolation module is similar to the first isolation module in the interface management module in function, and is used for enabling microwave energy signals sent by the microwave energy module to pass through and blocking radio frequency energy signals sent by the radio frequency energy module and/or pulse energy signals sent by the pulse energy module, so that high-voltage and low-frequency energy is prevented from damaging a microwave energy source device, and the microwave energy source device is used as a multiple isolation part of the microwave energy signals;
The radio frequency energy switch S7 and the pulse energy switch S8 are respectively used for controlling the passing of radio frequency energy signals and pulse energy signals;
the heating energy switch S10 and the refrigerating and heating energy switch S11 are connected, and when the heating medium is a fluid medium or a gas medium, the heating energy switch S10 is connected and the refrigerating and heating energy switch S11 is disconnected; when the heating medium is an electric medium, the heating energy switch S10 is turned on, and the refrigerating and heating energy switch S11 is turned off, so that different heating modes are selected.
The radio frequency energy switch S7, the pulse energy switch S8, the refrigerating and heating energy switch S11 and the heating energy switch S10 can only be in an on state at the same time, and the on energy switch function is realized, and meanwhile, the off switch realizes isolation protection with other energy platforms, so that crosstalk among energy signals is prevented.
The electric path is used for realizing the interface recombination of microwave, radio frequency and electric pulse energy, and is connected with the refrigerating or heating medium path to the interface of the compound accessory so as to realize the compound connection of the electric paths, refrigerating and heating energy paths of different accessories. The switches S7, S8, S10 may be mechanical relays or solid state isolation switches. The switch S11 may be a solenoid valve.
The various combinations of the microwave switches and the switches S1-S11 realize the switching function and can further realize isolation among energy signals. In particular, isolation between the composite accessory interface and the stand-alone accessory interface is achieved.
In some embodiments, the system may further include a cooling module for providing flowing liquid for cooling with a preset pressure to an accessory of at least one of the microwave energy module, the radio frequency energy module, and the pulse energy module, so as to provide cooling operation to the accessory to be cooled in time, thereby ensuring smooth performance of the ablation procedure. The appendages herein include, but are not limited to, ablation needle shafts.
In some examples, the cooling module may employ peristaltic pumps or pressure pumps to deliver cooling fluid to the needle bar or like accessory that is to be cooled.
In some embodiments, the system may further include a temperature measurement module configured to measure a temperature of an attachment of at least one of the microwave energy module, the radio frequency energy module, and the pulse energy module, or to measure a temperature of a target tissue to be ablated using at least one of the microwave energy module, the radio frequency energy module, and the pulse energy module, to ensure successful ablation procedures.
In some embodiments, the above system may further comprise:
the man-machine interaction module is used as a man-machine interaction interface to realize the input and display of user instructions and related parameters; the man-machine interaction module can use a key input mode, can also use a touch screen input mode, can use an LED nixie tube for displaying, and can also use an LCD or an LED display screen for displaying.
The main control module is connected with the man-machine interaction module, the microwave energy module, the radio frequency energy module, the pulse energy module, the freezing energy module, the interface management module and the composite accessory interface and used for processing related data of the man-machine interaction module and monitoring and controlling states of all the modules. The main control module can realize the overall work control and coordination of each module. The main control module takes a microcontroller as a core, can be a computer, an industrial control computer or an MCU (micro control unit, microcontroller Unit) and is matched with an external circuit to realize the required functions.
In some application scenarios, the user command is, for example, start, pause, stop, reset, work combination, workflow of each module, etc. The relevant parameters are parameters such as power, time, temperature, impedance of microwave energy, parameters such as power, time, temperature, impedance of radio frequency, parameters such as pulse amplitude, waveform, frequency, gap time, pulse wave number, impedance of pulse energy, and parameters such as freezing energy, time, temperature of freezing operation. The related preset, real-time, state and other parameters can be displayed in digital, graphic, video and other modes. The man-machine interaction module receives the instruction of the user, and after analysis, the instruction can be transmitted to the main control module in a data packet or state mode; the main control module receives the data and the instructions of each module, and sends the data and the instructions to the man-machine interaction module, and the man-machine interaction module displays the data, the graphics, the video and the like.
In some application scenarios, the main control module receives and processes instructions such as starting, suspending, stopping, resetting and the like of the work of each module, and is used for controlling the work and stopping of each work module; receiving and processing a work combination mode to control single-module work or multi-module work; receiving and processing the work flow of each module to control the logic and sequence of the work of each module, and switching the switch of each module to the corresponding position in the corresponding stage; receiving and processing working parameters of each energy module, including parameters such as power, time, temperature, impedance and the like of microwave energy; parameters such as power, time, temperature, impedance and the like of the radio frequency energy; pulse amplitude, waveform, frequency, gap time, pulse wave number, impedance and other parameters of pulse energy; parameters such as freezing energy, time, temperature and the like of the freezing operation are transferred to each module, and are used for controlling the ablation range of each energy treatment mode and controlling or assisting in controlling the working logic of each energy module.
In some possible application examples, the circuits or structures shown in fig. 3 and fig. 4 may be simultaneously set in the above-mentioned system, and in specific use, the switching may be selected according to needs, for example, the selection of the circuits or structures of the impedance/interface converter may be implemented by a main control module, for example, the main control module controls the circuits or structures shown in fig. 3 or fig. 4 to be turned on by acquiring a radio frequency or pulse energy signal in a low frequency state or a high frequency state, so as to perform impedance transformation, and implement the most efficient transmission of the signal.
In other possible application examples, only the circuit or the structure shown in fig. 3 or fig. 4 may be provided in the above system, and accordingly, a system provided with different impedance/interface converters is selected according to the working requirements of the low-frequency or high-frequency state, and is put into use.
It should be understood that the above examples of possible applications are not meant to limit the invention, but merely to illustrate some of the possibilities in practical applications.
In some embodiments, the system of the present invention further comprises a ECG (Electrocardiogram) module, connected to the main control module, for acquiring and transmitting the electrocardiogram signals of the human body. Since the ECG module acts on the human heart, the ECG module needs to be electrically isolated from other parts to meet the requirements of the CF application part of the medical product. In some application examples, the ECG signal may be obtained by acquiring external electrocardiosignals for conditioning, or the system may acquire and condition the ECG signal through an acquisition chip and a circuit.
In some embodiments, the system of the present invention further comprises a power module for providing each module with an ac or dc voltage required for operation and for enabling energy detection and control of each voltage. In practical application, the power supply module can adopt an AC/DC analog power supply, and also can adopt a switch power supply, and the circuit is matched with various protection and monitoring circuits, so that the voltage, current and working state of the power supply can be monitored and fed back in real time in working.
The composite accessory interface is used as an interface for connecting the composite accessories, and the composite accessories can be at least two kinds of energy in microwave, radio frequency, pulse and freezing, and can also be connected with a single energy accessory.
The independent accessory interface is used for connecting a single energy accessory interface, and the independent accessory interface can be respectively or simultaneously connected with corresponding microwave, radio frequency, pulse and freezing energy accessories so as to realize corresponding energy output. The independent accessory interface can also be connected with a composite accessory, so that the corresponding single function can be realized. The energy signals corresponding to the independent accessory interfaces can be independently output within the same period, and at least two groups of energy signals can be simultaneously output for use.
The unused energy signals in the composite accessory interface or the independent accessory interface can be used in the respective external interfaces.
The microwave, radio frequency, pulse and freezing energy sources (energy modules) are at least one channel, and can also be a plurality of channels; each type of energy channel may be configured in a balanced manner or may be configured in an unbalanced manner. For example, the microwave, radio frequency, pulsed and chilled energy modules are all configured in one or more balanced configurations, or some are configured in one and some are configured in multiple unbalanced configurations throughout the system.
It should be noted that, in this document, the terms "first," "second," and the like in the description and the claims of the present application and the above drawings are used for distinguishing between similar objects and not necessarily for describing a particular sequential or chronological order. The terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising one … …" does not exclude the presence of other like elements in a process, method, article, or apparatus that comprises the element.
Although the embodiments of the present application are described above, the embodiments are only used for facilitating understanding of the present application, and are not intended to limit the present application. Any person skilled in the art can make any modification and variation in form and detail without departing from the spirit and scope of the present disclosure, but the scope of the present disclosure is still subject to the scope of the appended claims.
Claims (13)
1. A multi-modal physical field tumor ablation treatment system, comprising: the device comprises a microwave energy module, a radio frequency energy module, a pulse energy module, a freezing energy module, an interface management module and a composite accessory interface for connecting the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module;
the interface management module is connected with the composite accessory interface, the composite accessory interface is connected with a single accessory or a composite accessory, the single accessory comprises a single accessory corresponding to any one of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module, and the composite accessory comprises composite accessories corresponding to more than two of the microwave energy module, the radio frequency energy module, the pulse energy module and the freezing energy module;
the interface management module comprises:
the first impedance/interface converter is connected between the radio frequency energy module and the composite accessory interface and is used for converting the impedance of the pulse energy signal sent by the radio frequency energy module into the same impedance as the microwave energy signal sent by the microwave energy module;
The second impedance/interface converter is connected between the pulse energy module and the composite accessory interface and is used for converting the impedance of the pulse energy signal sent by the pulse energy module into the same impedance as the impedance of the microwave energy signal sent by the microwave energy module;
the first impedance/interface converter or the second impedance/interface converter adopts an impedance conversion circuit or an impedance conversion structure;
when the impedance conversion structure is in a coaxial structure, the first impedance/interface converter or the second impedance/interface converter adopts the microstrip circuit or the coaxial structure under the condition that the radio frequency energy signal or the pulse energy signal works in a set low-frequency state;
the first impedance/interface converter or the second impedance/interface converter comprises an impedance converter and an impedance interface, the impedance converter comprises a first outer insulator, a first conductor, a first medium and a second conductor, and the impedance interface comprises a second outer insulator, a third conductor, a second medium and a fourth conductor;
the first conductor is arranged outside the second conductor, the first medium is arranged between the first conductor and the second conductor, and the first outer insulator is arranged outside the first conductor; the third conductor is arranged outside the fourth conductor, the second medium is arranged between the third conductor and the fourth conductor, and the second outer insulator is arranged at the joint of the impedance converter and the impedance interface and is integrated with the first outer insulator; the second medium ring completely wraps the fourth conductor, the length of the front end of the second medium exceeds that of the fourth conductor, and the set length or the set width is kept, so that enough electric gap and creepage distance between the fourth conductor and the third conductor are ensured.
2. The multi-modality physical field tumor ablation treatment system of claim 1, wherein the interface management module further comprises:
the first isolation module is connected between the microwave energy module and the composite accessory interface and is used for enabling microwave energy signals sent by the microwave energy module to pass through and blocking radio frequency energy signals sent by the radio frequency energy module and/or pulse energy signals sent by the pulse energy module;
the refrigerant/heating regulation and control assembly is connected between the freezing energy module and the composite accessory interface and is used for regulating and controlling freezing operation and rewarming operation.
3. The multi-modality physical field tumor ablation treatment system of claim 2, further comprising: the independent accessory interface comprises a microwave interface, a radio frequency interface, a pulse interface and a freezing interface, and is used for being connected with a single accessory to realize the output of corresponding single energy or connected with a composite accessory to realize the output of single energy.
4. The multi-modality physical field tumor ablation treatment system of claim 2, further comprising:
the first radio frequency energy module switch is connected between the radio frequency energy module and the first impedance/interface converter and used for switching radio frequency energy to the first impedance/interface converter;
The first pulse energy module switch is connected between the pulse energy module and the second impedance/interface converter and used for switching pulse energy to the second impedance/interface converter;
the first refrigeration medium/heating medium switch is connected between the refrigeration energy module and the refrigerant/heating regulation and control assembly and is used for controlling the refrigeration medium or the heating medium to the refrigerant/heating regulation and control assembly.
5. The multi-modality physical field tumor ablation treatment system of claim 4, further comprising:
the microwave module switch is connected between the isolation module and the composite accessory interface and is positioned between the isolation module and the microwave interface and used for distributing microwave energy to the composite accessory interface or the independent accessory interface;
the second radio frequency energy module switch is connected between the radio frequency energy module and the radio frequency interface of the independent accessory interface and used for distributing radio frequency energy to the radio frequency interface;
the second pulse energy module switch is connected between the pulse energy module and the pulse interface of the independent accessory interface and used for distributing pulse energy to the pulse interface;
the second refrigeration medium/heating medium switch is connected between the refrigeration energy module and the refrigerant/heating regulation and control assembly and is used for controlling the connection of the refrigeration medium or the heating medium to the refrigeration interface of the refrigerant/heating regulation and control assembly and the independent accessory interface.
6. The multi-modality physical field tumor ablation treatment system of claim 2, further comprising: the multi-channel switcher is connected to the front end of the composite accessory interface and is used for realizing the coupling connection between the energy signals output by the energy modules and the composite accessory interface, and one energy signal is selected to be output to the composite accessory interface at any moment.
7. The multi-mode physical field tumor ablation treatment system according to claim 1, wherein the impedance conversion circuit is in the form of an impedance stepped or impedance graded microstrip circuit, and when the impedance conversion structure is in the form of an impedance stepped or impedance graded coaxial structure, the first impedance/interface converter or the second impedance/interface converter adopts the impedance stepped or impedance graded microstrip circuit or the impedance stepped or impedance graded microstrip circuit when the radio frequency energy signal or the pulse energy signal operates in a set high frequency state;
the first impedance/interface converter or the second impedance/interface converter comprises an impedance converter and an impedance interface, the impedance converter comprises a first outer insulator, a first conductor, a first medium and a second conductor, and the impedance interface comprises a second outer insulator, a third conductor, a second medium and a fourth conductor;
The first conductor is arranged outside the second conductor, the first medium is arranged between the first conductor and the second conductor, and the first outer insulator is arranged outside the first conductor; the third conductor is arranged outside the fourth conductor, the second medium is arranged between the third conductor and the fourth conductor, and the second outer insulator is arranged at the joint of the impedance converter and the impedance interface and is integrated with the first outer insulator;
the second conductor adopts a multi-section or multi-section structure, so that the impedance of the radio frequency energy signal or the impedance of the pulse energy signal is gradually converted into the same impedance as the impedance of the microwave energy signal sent by the microwave energy module, and the inner diameter or width of the first conductor and the size of the first medium are changed along with the outer diameter or width of the second conductor; the second medium ring completely wraps the fourth conductor, the length of the front end of the second medium exceeds the length of the fourth conductor, and the set length or the set width is kept, so that enough electric gap and creepage distance between the fourth conductor and the third conductor are ensured.
8. The multi-modality physical field tumor ablation treatment system of claim 6, wherein the coolant/heating regulation assembly comprises an electrical heating assembly, a first switch and a second switch, a first safety valve, a second safety valve, a first pressure gauge, a second pressure gauge, a first regulation valve, and a second regulation valve;
The first safety valve, the first pressure gauge and the first regulating valve are sequentially connected, the second safety valve, the second pressure gauge and the second regulating valve are sequentially connected, and the first switch, the electric heating component and the second switch are sequentially connected;
the heating medium is heated by adopting an electric heating mode or a fluid/gas medium heating mode;
in the case of an electric heating mode, the first switch and the second switch are used for isolating and controlling the input and output of an electric heating component in the electric heating mode, and the electric heating component is used as an electric heating energy and control component;
under the condition of adopting a fluid/gas medium heating mode, the heating medium is output through a first safety valve, a first pressure valve and a first regulating valve, wherein the first safety valve is used for controlling the maximum pressure of the input heating medium, the first pressure gauge is used for monitoring the pressure value of the heating channel, and the first regulating valve is used for regulating the flow or the pressure of the output heating medium; the refrigerating medium is output through a second safety valve, a second pressure gauge and a second regulating valve, wherein the second safety valve is used for controlling the maximum pressure of the input refrigerating medium, the second pressure gauge is used for monitoring the pressure value of the cooling passage, and the second regulating valve is used for regulating the flow or the pressure of the output cooling medium.
9. The multi-modal physical field tumor ablation therapy system of claim 8, wherein the microwave energy signal, the radio frequency energy signal, the pulse energy signal, the freeze energy signal are capable of interfacing with the composite accessory through the same electrical pathway, the multi-channel switch is configured to select one of the microwave energy signal, the radio frequency energy signal, the pulse energy signal, the freeze energy signal to be output to the composite accessory interface through the electrical pathway at any one time, the multi-channel switch comprising:
the second isolation module is used for enabling the microwave energy signal sent by the microwave energy module to pass through and blocking the radio frequency energy signal sent by the radio frequency energy module and/or the pulse energy signal sent by the pulse energy module;
the radio frequency energy switch and the pulse energy switch are respectively used for controlling the passing of the radio frequency energy signal and the pulse energy signal;
the heating energy switch is turned off and the refrigerating and heating energy switch is turned on when the heating medium is a fluid medium or a gas medium; when the heating medium is an electric medium, the heating energy switch is turned on, and the refrigerating and heating energy switch is turned off, so that the selection of different heating modes is realized.
10. The multi-modal physical field tumor ablation therapy system of claim 1, further comprising a cooling module for providing a flowing liquid for cooling at a preset pressure to an attachment of at least one of the microwave energy module, the radio frequency energy module, the pulse energy module.
11. The multi-modal physical field tumor ablation therapy system of claim 1, further comprising a thermometry module for measuring a temperature of an attachment to at least one of the microwave energy module, the radio frequency energy module, the pulse energy module, or for measuring a temperature of a target tissue being ablated with at least one of the microwave energy module, the radio frequency energy module, the pulse energy module.
12. The multi-modality physical field tumor ablation treatment system of claim 1, further comprising:
the man-machine interaction module is used as a man-machine interaction interface to realize the input and display of user instructions and related parameters;
the main control module is connected with the man-machine interaction module, the microwave energy module, the radio frequency energy module, the pulse energy module, the freezing energy module, the interface management module and the composite accessory interface and used for processing related data of the man-machine interaction module and monitoring and controlling states of all the modules.
13. The multi-modality physical field tumor ablation treatment system of claim 12, further comprising an ECG module, coupled to the master control module, for acquiring and transmitting human electrocardiogram signals.
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