CN116710065A - Oral composition - Google Patents

Abstract

The present invention aims to provide a non-aqueous oral composition with suppressed unpleasant taste. Disclosed is an oral composition which contains (A) a component having an unpleasant taste and (B) a plant extract and has a water content of 2 mass% or less. (B) The component preferably contains at least one selected from the group consisting of a radix et rhizoma Rhei extract, radix Paeoniae extract, radix Angelicae sinensis extract, herba Sidae Rhombifoliae extract, flos Matricariae Chamomillae extract and fructus Sapindi Mukouossi extract. (A) The component (c) preferably contains at least one selected from the group consisting of inorganic powders and surfactants. The oral composition preferably further comprises (C) a polyol having a melting point of 25 ℃ or lower.

Description

Oral composition

Technical Field

The present invention relates to an oral composition.

Background

If a polyhydric alcohol solvent such as glycerin or polyethylene glycol is used instead in order to impart a warm sensation to the dentifrice, the heat of hydration of the solvent generated by contact of the formulation with saliva during brushing can impart a warm sensation to the oral cavity.

Patent document 1 describes a nonaqueous oral care composition containing a specific organic polyol such as glycerin, a particulate abrasive such as anhydrous silicic acid, a surfactant, and xanthan gum. Patent document 2 describes a nonaqueous dentifrice composition containing a carboxyvinyl polymer, an anhydrous humectant such as glycerin, a polishing agent such as polyethylene glycol, silica, and calcium carbonate, and optionally a surfactant.

On the other hand, plant extracts may be incorporated into oral compositions for the purpose of imparting various physiological activities (for example, patent document 3).

Prior art literature

Patent literature

Patent document 1: japanese patent application laid-open No. 2016-507578

Patent document 2: japanese patent Kokai publication Hei-10-503189

Patent document 3: japanese patent No. 5285203

Disclosure of Invention

Problems to be solved by the invention

However, in nonaqueous, particularly, polyol-based dentifrices, unpleasant tastes such as bitter taste of matrix components (polyols, surfactants, inorganic powders, etc.) having unpleasant tastes such as bitter taste and astringent taste tend to be strongly exhibited as compared with aqueous systems. Therefore, especially for users who are sensitive to taste, the users cannot enjoy the temperature sensation of the nonaqueous system to the maximum extent and brush their teeth carefully.

The present invention aims to provide a nonaqueous oral composition with suppressed unpleasant taste.

Means for solving the problems

The present invention provides the following [1] to [8].

[1] An oral composition contains (A) an unpleasant-tasting component and (B) a plant extract, and has a water content of 2 mass% or less.

[2] The oral composition according to [1], wherein the component (B) contains at least one selected from the group consisting of a Yuehao extract, a Paeonia lactiflora extract, a Angelica sinensis extract, a calendula extract, a Matricaria chamomilla extract and a Sapindus mukurossi extract.

[3] The oral composition according to [1] or [2], wherein the content of the component (B) is 0.00001 to 0.1% by mass.

[4] The composition for oral cavity according to any one of [1] to [3], wherein the content of the component (B) is 0.00005 to 0.05 mass%.

[5] The composition for oral cavity according to any one of [1] to [4], wherein the component (A) contains at least one selected from the group consisting of inorganic powders and surfactants.

[6] The oral composition according to any one of [1] to [5], further comprising (C) a polyol having a melting point of 25 ℃ or lower.

[7] The composition for oral cavity according to [6], wherein the content of the component (C) is 20 to 85% by mass.

[8] The oral composition according to any one of [1] to [7], which is a dentifrice.

Effects of the invention

According to the present invention, unpleasant taste in a nonaqueous oral composition can be suppressed.

Detailed Description

[1] oral composition

[ (A) component having unpleasant taste ]

The oral composition comprises (A) component: ingredients with unpleasant taste are preferably contained with ingredients having bitter taste. (A) The component (c) is usually a component other than a nonaqueous organic solvent, and preferably an inorganic powder or surfactant having an unpleasant taste.

Inorganic powder

The inorganic powder is usually mixed as a tooth cleaner or thickener in an oral composition such as a dentifrice. Examples of the inorganic powder having an unpleasant taste include a silica-based material and a calcium-based material. Examples of the silica-based material include silica (precipitated silica, titanium-bonded silica, silica gel, aluminum silicate, and zirconium silicate). Examples of the calcium-based material include calcium carbonate (light weight and heavy weight); calcium phosphate-based materials such as dicalcium phosphate dihydrate or dicalcium phosphate anhydrous, monocalcium phosphate, tricalcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, tricalcium phosphate, tetracalcium phosphate, octacalcium phosphate, and the like; calcium hydroxide; inorganic substances such as calcium sulfate. Among them, silica is preferable. As the silica, silica having an RDA (Radioactive Dentin Abrasion, radioactive dentin polishing force) of 50 to 250 is preferably used. RDA can be determined according to the Hefferren method (Hefferren (1976) Journal of Dental Research (J. Dent. Study), july-August (7-8 months), 563-573). The size of the inorganic powder may be appropriately selected depending on the kind of the inorganic material constituting each powder, and is usually in the range of 0.1 to 40 μm, preferably 1 to 30 μm, in average particle diameter (D50 by volume basis, measurement value by laser diffraction/scattering method). The average particle diameter can be measured by adjusting the turbidity (dV value) of the sample to 0.5 using a particle size distribution measuring apparatus (for example, a microphone (Microtrac) particle size distribution measuring apparatus (model 117995-10, model SRA, manufactured by daily nectar corporation), and the average particle diameter shown in the examples below is a measured value by this method.

Content of inorganic powder

(A) The content of the inorganic powder component is preferably 8 mass% or more, more preferably 10 mass% or more. This can provide a moderate viscosity and a clean feel at the time of use. The upper limit is preferably 40 mass% or less, more preferably 30 mass% or less. Thus, the viscosity of the composition does not become excessively high, and good physical properties can be obtained. Therefore, the content of the inorganic powder is preferably 8 to 40 mass%, more preferably 10 to 30 mass%.

Surfactant-containing compositions

Examples of the surfactant having an unpleasant taste include amphoteric surfactants and anionic surfactants.

Examples of the amphoteric surfactant include betaine type amphoteric surfactants such as alkyl dimethylaminoacetic acid betaine (e.g., lauryl dimethylaminoacetic acid betaine) and fatty acid amidopropyl betaine (e.g., cocamidopropyl betaine, fatty acid amidopropyl dimethylaminoacetic acid betaine, and lauric acid amidopropyl betaine); n-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salt (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine); imidazoline type amphoteric surfactants such as coconut fatty acid imidazolinium betaine and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine. The number of carbon atoms of the alkyl group or the acyl group is preferably 8 to 18. Among them, betaine type amphoteric surfactants are preferable, fatty acid amidopropyl betaines are more preferable, and cocamidopropyl betaine and lauramidopropyl betaine are more preferable.

Examples of the anionic surfactant include alkyl sulfate, acyl amino acid salt, acyl taurate, alpha-olefin sulfonate, hydrogenated coconut oil fatty acid monoglyceride monosulfate, and lauryl sulfoacetate. The alkyl group and the acyl group may be either a straight chain or a branched chain, or may be either saturated or unsaturated, and the number of carbon atoms thereof is usually 10 to 20, preferably 12 to 18, more preferably 12 to 14. The salt may be selected from pharmacologically acceptable salts. Examples of the pharmacologically acceptable salts include inorganic basic salts such as sodium salt, potassium salt, calcium salt, magnesium salt, and ammonium salt; organic base salts such as triethylammonium salt, triethanolammonium salt, pyridinium salt, diisopropylammonium salt, and the like; arginine salts, lysine salts, histidine salts, and the like. Among them, inorganic alkali salts are preferable, alkali metal salts (e.g., sodium salt, potassium salt) or ammonium salt are more preferable, and sodium salt is still more preferable.

Examples of the alkyl sulfate include lauryl sulfate and myristyl sulfate. Examples of the acyl amino acid salt include acyl sarcosinates such as lauroyl sarcosinate and myristoyl sarcosinate; lauroyl glutamate; acyl glutamates such as myristoyl glutamate, palmitoyl glutamate, and the like; acyl glycinates such as N-lauroyl-N-methylglycinate and cocoyl glycinate; alanine salts such as N-lauroyl- β -alanine salt, N-myristoyl- β -alanine salt, N-cocoyl- β -alanine salt, N-lauroyl-N-methyl- β -alanine salt, N-myristoyl-N-methyl- β -alanine salt, and N-methyl-N-acyl alanine salt; acyl aspartate such as lauroyl aspartate. Examples of the acyl taurates include lauroyl methyl taurate, N-methyl-N-acyl taurate, and N-cocoyl methyl taurate. Examples of the α -olefin sulfonate include 12 to 18 carbon atoms such as tetradecene sulfonate. Other examples of the anionic surfactant include sodium hydrogenated coconut oil fatty acid monoglyceride monosulfate and sodium lauryl sulfoacetate. As the anionic surfactant, α -olefin sulfonic acid is preferable, and tetradecene sulfonate is more preferable.

Content of surfactant-

(A) When the component contains a surfactant, the content of each of the anionic surfactant and the amphoteric surfactant is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, relative to the composition. Thus, sufficient foaming performance can be obtained. The upper limit is preferably 3 mass% or less, more preferably 2.5 mass% or less. Thus, the bitterness in the composition can be sufficiently suppressed. Therefore, the content of the surfactant is preferably 0.1 to 3% by mass, more preferably 0.3 to 2.5% by mass.

In the present specification, the content of each component is an amount based on the amount of each component added when producing the oral composition.

(A) The component (c) may be 1 component having an unpleasant taste, or may be a combination of 2 or more components. (A) The component (c) preferably contains an inorganic powder and a surfactant, and more preferably contains an inorganic powder, an amphoteric surfactant and an anionic surfactant.

[ (B) plant extract ]

The oral composition comprises (B) component: plant extracts. By containing the component (B), the bitterness peculiar to the nonaqueous composition due to the component (A) can be reduced.

Raw material plant-

The plant extract may be any extract obtained by extracting at least a part of the raw plant. Examples of the plant material include a peach, a peony, a angelica, a calendula, a chamomile, and a soapberry. Examples of the extraction site include leaves, stems, roots, flowers, pericarps, and combinations thereof, and may be appropriately selected according to the plant type and/or extraction method.

Extraction of

Examples of the extraction solvent include water, a polar solvent, a nonpolar solvent, and a mixed solvent thereof. Examples of the polar solvent include diethyl ether, vinyl chloride, dioxane, acetone, alcohols (for example, lower 1-membered alcohols having 1 to 5 carbon atoms such as ethanol, methanol, propanol and isopropanol), glycols (for example, propylene glycol and butylene glycol), ethyl acetate and glycerin. Examples of the nonpolar solvent include n-hexane, petroleum ether, volatile oil (ligroin), cyclohexane, carbon tetrachloride, chloroform, methylene chloride, 1, 2-dichloroethane, toluene, and benzene. Among them, hydrophilic solvents are preferable, water, lower monohydric alcohol having 1 to 5 carbon atoms, glycol, and a mixed solvent of 2 or more selected from them are preferable, water, ethanol, propylene glycol, butylene glycol, and a mixed solvent of 2 or more selected from them are more preferable, and water is more preferable. The mixed solvent is preferably a mixed solvent of water and a lower monohydric alcohol or glycol, and more preferably a mixed ratio of water to a lower monohydric alcohol or glycol of 10: 90-90: 10 (mass ratio) of the mixed solvent.

Examples of the extraction method include a method of collecting a sample from an extraction site of a plant, pulverizing the sample as needed, and then performing extraction treatment using an extraction solvent; the extraction residue obtained after the extraction is used as a raw material, and the solvent is used for extraction treatment. After the extraction treatment, post-treatments such as concentration, dilution, powdering (for example, powdering by a shaping treatment with dextrin), and pulverization may be performed as needed. Examples of the form of the extract include liquid, powder, and solid, but are not particularly limited.

Examples of plant extracts

The component (a) may be a plant extract obtained from the above-mentioned plants, and may be purified to a single component or a combination of components contained in each plant, or may be a commercially available product. Preferred examples are as follows.

The extract of the radix seu fructus Alpiniae Officinarum: for example, an extract obtained by extracting a leaf of Alpinia speciosa (Alpinia speciosa) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (for example, ethanol), a glycol (for example, 1, 3-butanediol), or a mixed solvent of 2 or more selected from them; the yueqiao extract typically contains flavonoids, saccharides, 7, 8-dihydro-5, 6-dehydrokava-piperin (alpha-pyrones), eucalyptol, pinene and borneol (born), methyl cinnamate.

Paeonia lactiflora extract: for example, an extract obtained by extracting root of Paeonia lactiflora (Paeonia lactiflora) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (e.g., ethanol), a glycol (e.g., 1, 3-butanediol), or a mixed solvent of 2 or more selected from them; paeonia lactiflora extract usually contains monoterpene glycosides such as Peoniflorin (Peoniflorin) and tannins.

Angelica sinensis extract: for example, an extract obtained by extracting a root of Angelica sinensis (Angelica acutiloba) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (for example, ethanol), a glycol (for example, 1, 3-butanediol), or a mixed solvent of 2 or more selected from them; angelica sinensis extract usually contains essential oils, fatty acids, coumarin derivatives, phthalides (phthalides) and polyacetylene compounds.

Calendula extract: for example, an extract obtained by extracting a flower of calendula (Calendula officinalis) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (for example, ethanol), a glycol (for example, 1, 3-butanediol), or a mixed solvent of 2 or more selected from them; calendula extract usually contains tannins, triterpenoids (calendula) a.

Matricaria chamomilla extract: for example, an extract obtained by extracting flowers of Matricaria chamomilla (Matricaria chamomilla, chamomilla recutita (matricaria)) with water, a lower monohydric alcohol having 1 to 5 carbon atoms (for example, ethanol), a glycol (for example, 1, 3-butanediol), or a mixed solvent of 2 or more kinds selected from them; the chamomile extract typically contains tannins, flavonoids, coumarin derivatives (phetamine, umbelliferone), essential oil components (Azulene).

Soapberry extract: for example, from the pericarp of soapberry (Sapindus mukorossi), water, a lower monohydric alcohol having 1 to 5 carbon atoms (for example, ethanol), a glycol (for example, 1, 3-butanediol), or a mixed solvent of 2 or more selected from them is used; soapberry extract typically contains saponins (Saponin glycoside).

(B) The components may be 1 plant extract alone or 2 or more.

Content of the component (B)

(B) The content of the component (extract purity) is usually 0.00001 mass% or more, preferably 0.00003 mass% or more, and more preferably 0.00005 mass% or more, relative to the total amount of the composition. This can fully exert the bitterness-improving effect. The upper limit is usually 0.3 mass% or less, preferably 0.1 mass% or less, and more preferably 0.05 mass% or less. This can suppress deterioration of the feel and appearance of the component (B) due to the generation of bitter taste. Therefore, the content of the component (B) is usually 0.00001 to 0.1 mass% or 0.00001 to 0.3 mass%, preferably 0.00003 to 0.1 mass%, more preferably 0.00005 to 0.05 mass%.

[ (C) polyol having melting point of 25 ℃ or lower ]

The oral composition preferably contains (C): a polyol having a melting point of 25 ℃ or less is used as a liquid medium. By containing the component (C), the temperature sensation can be imparted to the oral composition by the heat of hydration of the solvent.

Examples of polyols having a melting point of 25℃or below

Examples of the polyhydric alcohol having a melting point of 25℃or lower include glycerin (melting point: 17.8 ℃), polyethylene glycol (e.g., polyethylene glycol having an average molecular weight of 190 to 650), propylene glycol (melting point: 59 ℃), dipropylene glycol (melting point: 39 ℃), butylene glycol (melting point: 77 ℃) and polypropylene glycol. Among them, glycerin, polyethylene glycol, and butylene glycol are preferable, and a combination of at least glycerin and polyethylene glycol is more preferable from the viewpoint of improving the sensation of temperature in the oral cavity. The number of these may be 1 alone or 2 or more.

The average molecular weight of the polyethylene glycol is generally 650 or less, preferably 630 or less, more preferably 600 or less. The lower limit is usually 150 or more, preferably 250 or more. Accordingly, it is usually 150 to 650, preferably 150 to 630, more preferably 250 to 600. As polyethylene glycol, polyethylene glycol 200 (average molecular weight 190 to 210, melting point: -50 ℃ C.), polyethylene glycol 400 (average molecular weight 380 to 420, melting point: 5 ℃ C.), polyethylene glycol 600 (average molecular weight 570 to 630, melting point: 22 ℃ C.) can be used, for example. In the present specification, the average molecular weight of polyethylene glycol is the average molecular weight described in the pharmaceutical unit external raw material specification 2006.

Content of the component (C)

(C) The content of the component (a) is usually 20% by mass or more, preferably 40% by mass or more, relative to the total amount of the composition. The upper limit is usually 85 mass% or less, preferably 80 mass% or less. By satisfying the above upper limit and/or lower limit, the appearance and viscosity of the oral composition can be improved. Therefore, the content of the component (C) is usually 20 to 85% by mass, preferably 40 to 80% by mass.

Glycerol content-

(C) When the component (C) contains glycerin, the content thereof is usually 20% by mass or more, preferably 40% by mass or more, and more preferably 50% by mass or more, relative to the total amount of the component (C). This can suppress bitterness caused by non-aqueous liquid components other than glycerin (e.g., polyethylene glycol and propylene glycol). The upper limit is usually 90 mass% or less, preferably 80 mass% or less, but is not particularly limited. Therefore, the content of glycerin is usually 20 to 100% by mass, preferably 40 to 90% by mass, more preferably 50 to 80% by mass.

Content of polyethylene glycol

(C) When the component (C) contains polyethylene glycol (for example, polyethylene glycol having an average molecular weight of 190 to 630), the content thereof is usually 10% by mass or more, preferably 15% by mass or more, relative to the total amount of the component (C). This can give a good temperature sensation. The upper limit is usually 30 mass% or less. Thus, the product has a good flavor without bitter taste. Therefore, the content of polyethylene glycol is usually 10% by mass or more, preferably 15 to 30% by mass.

[ moisture content ]

The oral composition is a nonaqueous composition containing substantially no moisture. Thus, when the composition is used, moisture contacts with each component (mainly component (C)) of the composition in the oral cavity, and hydration heat can be generated, and a temperature sensation can be exhibited in the oral cavity. The water content is usually 2% by mass or less, preferably 1% by mass or less, and more preferably 0.5% by mass or less. The moisture content may be calculated as a ratio (%) of the total moisture content of the raw materials (e.g., component (B)) before mixing to the total raw materials, or as a ratio (%) of the difference between the weight of the oral composition after drying and the weight before drying to the weight before drying. The moisture amount in the following examples is a value calculated by the former method.

[ optional ingredients ]

The oral composition may contain other components than the components (a) to (C) within a range that does not impair the effects of the present invention. Examples of the other ingredients include, but are not limited to, surfactants, sweeteners, flavors, abrasives, humectants, binders, organic abrasives, pH adjusters, preservatives, pharmaceutically effective ingredients, oily ingredients, colorants (pigments), and the like, which can be mixed in the oral composition.

Surfactant (other than component A)

Examples of the surfactant other than the component (a) include nonionic surfactants and cationic surfactants.

Examples of the cationic surfactant include alkylammonium salts and alkylbenzylammonium salts.

Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester (for example, polyoxyethylene sorbitan monostearate), alkyl alcohol amide, polyoxyethylene fatty acid ester, polyoxyethylene alkenyl ether, glycerin fatty acid ester, sucrose fatty acid ester (for example, maltitol fatty acid ester), sugar alcohol fatty acid ester (for example, maltitol fatty acid ester, lactitol fatty acid ester), fatty acid diethanolamide (for example, lauric acid monoethanolamide or lauric acid diethanolamide), polyoxyethylene polyoxypropylene copolymer, and polyoxyethylene polyoxypropylene fatty acid ester. The number of carbon atoms of the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average molar number of addition of ethylene oxide is usually 15 to 30. The average molar number of ethylene oxide addition of the polyoxyethylene hydrogenated castor oil is usually 20 to 100 mol, preferably 20 to 60 mol. The fatty acid of the sorbitan fatty acid ester has usually 12 to 18 carbon atoms. The fatty acid of the polyoxyethylene sorbitan fatty acid ester has usually 16 to 18 carbon atoms, and the average molar number of ethylene oxide addition is usually 10 to 40 moles. The number of carbon atoms in the alkyl chain of the alkyl alcohol amide is usually 12 to 14. As the nonionic surfactant, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene alkyl ethers are preferable.

When the anionic surfactant and the cationic surfactant are contained, the content of each is usually 0.01 to 10% by mass, preferably 0.1 to 5% by mass, more preferably 0.2 to 3% by mass of the entire composition.

Sweetener-

The use feeling can be further improved by including a sweetener in the composition. Examples of the sweetener include xylitol, erythritol, maltitol, saccharin sodium, aspartame, stevioside extract, p-methoxycinnamaldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, aspartame, and the like. The sweetener may be used alone or in combination of 1 or more than 2.

Fragrance-mixing

The composition contains a perfume, so that the feeling of use can be further improved. Examples of the perfume include natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamon oil, rosemary oil, marjoram oil, lemon oil, orange oil, nutmeg oil, lavender oil, jambolan (Paracres) oil, cinnamon oil, multi-fragrant citrus fruit oil, cinnamon leaf oil, and perilla oil; perfume components contained in the above natural essential oils such as menthol, carvone, cinnamaldehyde, anethole, 1, 8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol (spilanthol), n-decanol, citronellol, alpha-terpineol, citronellol acetate, eucalyptol, ethyl linalool, and vanillin; perfume components such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furanone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, and ethylene glycol-l-menthyl carbonate; and various blended flavors such as peppermint, fruit, and vanilla, which are composed of a plurality of flavor components and/or a plurality of natural essential oils. The perfume may be used alone or in combination of at least 2 kinds.

Pharmaceutical compositions

Examples of the pharmaceutical ingredient include antibacterial or antifungal agents such as cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, isopropyl methylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; glucanase, glucan allosteric hydrolase, amylase, protease, leTech enzyme, and the like; fluoride such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; anti-inflammatory agents such as epsilon-aminocaproic acid, allantoin, tranexamic acid, glycyrrhetate (e.g., potassium salt of glycyrrhizic acid 2), glycyrrhetinic acid, stearyl glycyrrhetinate, aluminum cloxas, azulene, and dihydrocholesterols; metal salts such as zinc, copper salts, and tin salts; dental prophylaxis agents such as condensed phosphates and ethane hydroxy diphosphonates; blood flow promoters such as vitamin E (e.g., tocopheryl acetate); sensitive inhibitors such as potassium nitrate, aluminum lactate, strontium chloride, etc.; coating agents such as hydroxyethylcellulose dimethyl diallyl ammonium chloride; astringents such as vitamin C (e.g., ascorbic acid or its salt), lysozyme chloride, sodium chloride, etc.; water-soluble copper compounds such as copper chlorophyll and copper gluconate; a dental stone preventive agent such as zeolite, and an amino acid such as alanine, glycine, proline; fur seal peptide and polyvinylpyrrolidone. The pharmaceutical ingredients may be used alone or in combination of 1 or more than 2. The content of the other active ingredient may be appropriately set to an effective amount.

Oily component-

Examples of the oily component include hydrocarbons such as squalane, liquid paraffin, vaseline, and microcrystalline paraffin; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, isostearyl alcohol, etc.); higher fatty acids (for example, fatty acids having 8 to 22 carbon atoms such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; fatty acid esters such as isopropyl myristate.

Abrasive ((A) other than)

Examples of the polishing agent include inorganic polishing agents and organic polishing agents other than the component (a). Examples of the inorganic abrasive include aluminum-based materials such as aluminum oxide, aluminum hydroxide, and alumina (aluminum); silicic acid-based materials such as anhydrous silicic acid, zeolite, and zirconium silicate; magnesium materials such as magnesium carbonate and magnesium tribasic phosphate; apatite materials such as hydroxyapatite, fluorapatite and calcium-deficient apatite; titanium-based materials such as titanium dioxide, titanium mica, and titanium oxide; crystalline zirconium silicate; bentonite, and other minerals. Examples of the organic polishing agent include polymethyl methacrylate and synthetic resin polishing agents. The content of the abrasive is preferably 0 to 10 mass%. The total amount of the component (a) is preferably 50% by mass or less, more preferably 8 to 50% by mass, based on the entire composition.

Preservative-

By the composition containing a preservative, the preservative power of the formulation can be ensured. Examples of the preservative include parahydroxybenzoates (e.g., methyl parahydroxybenzoate, ethyl parahydroxybenzoate, butyl parahydroxybenzoate), sodium benzoate, and the like. The preservative may be used alone or in combination of at least 2.

Wetting agent-

The composition may further improve the feel in use by containing any humectant. As the wetting agent, polyhydric alcohols other than the component (C) are preferable, and examples thereof include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, xylitol and the like; diols such as propylene glycol and ethylene glycol; reducing the starch saccharification. The content of the wetting agent is usually 0 to 20% by mass, preferably 1 to 10% by mass.

Adhesive agent

Examples of the optional binder include known organic binders, such as cellulose-based binders (e.g., carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl methylcellulose, methyl cellulose, and cationized cellulose), carrageenan, xanthan gum, carboxyvinyl polymer, guar gum, tragacanth gum, karaya gum, acacia gum, locust bean gum, sodium alginate, montmorillonite, sodium polyacrylate, polyvinylpyrrolidone, polyvinyl alcohol, and propylene glycol alginate. The content of any binder is preferably 0 to 1.0 mass%, more preferably 0.1 to 0.8 mass%.

pH regulator-

By the composition containing a pH adjuster, the pH stability of the formulation can be ensured. Examples of the pH adjuster include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, and salts thereof; inorganic acids such as phosphoric acid (orthophosphoric acid) or salts thereof (for example, potassium salt, sodium salt and ammonium salt); hydroxide such as sodium hydroxide and potassium hydroxide. Examples of the inorganic acid salt include disodium hydrogen phosphate and sodium dihydrogen phosphate. The content of the pH adjustor is usually such an amount that the pH of the composition after addition becomes 5 to 9, preferably 6 to 8.5. In the present specification, the pH is usually a value from the start of measurement to 25℃for 3 minutes, and can be measured by using a pH meter (model Hm-30S) manufactured by Toyama electric wave industry Co.

Other optional ingredients

Examples of any component other than the above include waxes such as carnauba wax, rosin, rice bran wax, microcrystalline wax, beeswax, and paraffin wax; higher alcohols such as cetyl alcohol and stearyl alcohol; polyisobutylene, polybutadiene, polyurethane, silicone (コ), natural rubber. The content of these components may be appropriately set within a range that does not hinder the effects of the present invention.

The oral compositions of the present invention may be formulated into any suitable dosage form by any suitable method according to conventional methods. Examples of the dosage form include liquids (solutions, emulsions, suspensions, syrups, etc.), semisolids (gels, ointments, pastes, etc.), solids (tablets, granules, capsules, films, kneaded materials, melted solids, waxy solids, elastic solids, soft capsules, etc.). The dosage form of the oral composition is preferably a liquid, semi-solid.

The oral composition of the present invention can be widely used for oral application. Examples of the use of the solid dosage form include a dentifrice such as a lozenge (troche), a soft candy (gum), a gum (gum), a powder or a tablet. Examples of the use of the semisolid formulation include toothpaste and gel dentifrice. Examples of the use of the liquid formulation include mouthwashes, liquid dentifrices, and in-mouth coolants (sprays and the like). The oral composition of the present invention is preferably a dentifrice (toothpaste, gel dentifrice).

[2] Process for producing composition ]

The method for producing the oral composition is not particularly limited, and the oral composition can be produced by a usual method depending on the dosage form. For example, when the toothpaste is used, there is a method of preparing a component dissolved in a solvent, mixing the other insoluble components, and if necessary, defoaming (for example, depressurizing or the like). The obtained toothpaste can be stored in a container to make into product. The shape and material of the container are not particularly limited, and a container used in a usual toothpaste composition may be used, and examples thereof include plastic containers such as polyethylene, polypropylene, polyethylene terephthalate and nylon.

Examples (example)

Hereinafter, the present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to the examples. Unless otherwise specified, the% in the table represents% by mass.

[ Main raw materials used in examples and comparative examples ]

The main materials used in examples and comparative examples are summarized below.

(A) The components are as follows:

silica: tixosil (registered trademark) 73 (average particle diameter 9 μm) manufactured by Solvay company

Coconut oil fatty acid amidopropyl betaine: TEGO Betrain CK D, manufactured by Evonik Co

Sodium tetradecene sulfonate: lion Specialty Chemicals, K LIPOLAN PJ-400CJ

(B) The components are as follows: as shown in Table 1

TABLE 1

Table 1 example B component

(C) The components are as follows:

glycerol: concentrated glycerin for cosmetics manufactured by sakazakii pharmaceutical industry (ltd)

Polyethylene glycol: polyethylene glycol 400 manufactured by Sanyo chemical industry Co., ltd

Butanediol: 1,3-BG (Cosmetic Quality) manufactured by Chang-Kagaku Kogyo Co., ltd

Propylene glycol: propylene glycol manufactured by ADEKA

Other components:

carrageenan: GENUVISCO PJ-JPE manufactured by Sanzhi Co., ltd

Sodium carboxymethyl cellulose: cellophane fine chemical industry, CMC1260

Polyoxyethylene hydrogenated castor oil: nikkol HCO-20, manufactured by Nikkol Corp

Other components are used in accordance with the pharmaceutical portion external raw material specification 2006.

Examples 1 to 14 and comparative example 1 (dentifrice)

Dentifrice compositions having the formulation compositions (parts by mass) shown in tables 2 to 3 were prepared by the following preparation methods using the above components.

[ method for producing dentifrice composition ]

The raw materials shown in tables 2 to 3 (the amounts of component (B) in the tables are the amounts of the purity of the extract) were mixed by a usual method, and mixed at normal temperature using a 1.5L kneader (manufactured by Shishan Kagaku Co., ltd.) to perform deaeration under reduced pressure (pressure: 4 kPa) to obtain dentifrice compositions.

The resulting dentifrice composition was evaluated according to the following procedure. The evaluation results are shown in tables 2 to 3.

Evaluation method > evaluation of unpleasant taste (bitterness) in oral cavity during tooth brushing

1g of the dentifrice composition was placed on a toothbrush (toothbrush of 4 rows of compact general, manufactured by lion king corporation), and the presence or absence of unpleasant bitter taste remaining on the tongue peculiar to a nonaqueous base in the oral cavity when brushing teeth in a usual manner was evaluated on a 5-step scale according to the following evaluation. Average scores of 10 subjects sensitive to taste were calculated and expressed in the table as++, ++, +, -according to the following evaluation criteria. Taste sensitive testers were selected in a questionnaire from those having experience of "use was discontinued or brand changed due to the taste of the dentifrice in the past".

(evaluation criterion)

5, the method comprises the following steps: no bitter taste is felt at all

4, the following steps: slightly bitter taste

3, the method comprises the following steps: feel bitter taste

2, the method comprises the following steps: strongly feel bitter

1, the method comprises the following steps: very strongly feel bitter

(scoring)

+++: average more than 4.5 minutes

++: average 4.0 min or more and less than 4.5 min

+: an average of 3.0 minutes or more and less than 4.0 minutes

-: average 1.0 point or more and less than 3.0 points

Evaluation method > evaluation of temperature sensation during tooth brushing

1g of the dentifrice composition was placed on a toothbrush (toothbrush of Advantage, 4-column compact general, manufactured by lion king Co., ltd.) and the temperature sensation in the oral cavity when brushing teeth by a usual method was evaluated on 5 grades according to the following evaluation criteria. Average scores of 10 subjects sensitive to taste were calculated and represented in the table as++, ++, +, -according to the following evaluation criteria. The "temperature sensation" herein means that the oral mucosa is provided with a warm sensation. The taste sensitive experimenter selected from those having experience of "use was discontinued or brand changed due to the taste of the dentifrice" by questionnaire.

(evaluation criterion)

5, the method comprises the following steps: has very high temperature sense immediately after tooth brushing

4, the following steps: temperature sensing sense with distinguishable degree immediately after tooth brushing

3, the method comprises the following steps: has a temperature sense with a distinguishable degree in the tooth brushing process

2, the method comprises the following steps: hardly feel the temperature sense during the tooth brushing process

1, the method comprises the following steps: no temperature sense

(scoring)

+++: average 4.0 to 5.0 minutes

++: an average of 3.0 minutes or more and less than 4.0 minutes

+: average 2.5 min or more and less than 3.0 min

-: average 1.0 min to less than 2.5 min

TABLE 2

TABLE 3

TABLE 3 Table 3

In comparative example 1 containing only the component (a), bitterness during brushing was strongly perceived, whereas in each of examples containing the components (a) and (B), bitterness was suppressed, and in examples 1 to 6, 9 to 11, and 13, bitterness was not perceived at all. In addition, as shown in examples 1 to 14, the effect of the temperature sensation was also good. These results indicate that the present invention suppresses unpleasant tastes such as bitterness and provides an oral composition excellent in use feeling.

Claims (8)

1. An oral composition contains (A) an unpleasant-tasting component and (B) a plant extract, and has a water content of 2 mass% or less.

2. The oral composition according to claim 1, wherein the component (B) contains at least one selected from the group consisting of a yuetao extract, a peony extract, an angelica extract, a calendula extract, a chamomile extract and a soapberry extract.

3. The oral composition according to claim 1 or 2, wherein the content of the component (B) is 0.00001 to 0.1 mass%.

4. The composition according to any one of claims 1 to 3, wherein the content of the component (B) is 0.00005 to 0.05 mass%.

5. The oral composition according to any one of claims 1 to 4, wherein component (a) contains at least one selected from inorganic powders and surfactants.

6. The oral composition according to any one of claims 1 to 5, further comprising (C) a polyol having a melting point of 25 ℃ or less.

7. The oral composition according to claim 6, wherein the content of the component (C) is 20 to 85% by mass.

8. The oral composition of any one of claims 1-7, which is a dentifrice.