CN116688041A - 一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 - Google Patents
一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 Download PDFInfo
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Abstract
本发明涉及一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法,本发明中所述的清洗液由22‑33份滇白芷果、14‑20份五倍子、12‑16份水龙胆草、9‑13份侧柏叶、10‑14份黄柏、10‑13份地榆炭、4‑6份血竭、2‑4份冰片制成,可用于治疗溃疡性直肠炎,其治疗效果优良,安全性高。同时,本发明的清洗液制备工艺简单,成本低廉,易于推广应用。
Description
技术领域
本发明涉及一种中药清洗液,特别涉及一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法。
背景技术
直肠炎是指直肠部位发生炎症的疾病。溃疡性直肠炎主要发生在直肠黏膜及黏膜下层,其特点是肠黏膜屏障受损、肠道通透性增加以及溃疡形成。临床上常见的症状包括排便次数增多、腹泻、腹痛、伴有黏液脓血的大便、***疼痛和瘙痒等。该疾病的病程较长,易复发,给患者的生活和心理造成了极大的困扰。
传统中药治疗逐渐成为溃疡性直肠炎的替代治疗方法。多项临床研究表明,一些中药如当归、白术、栀子、黄柏等对溃疡性直肠炎有一定的治疗效果。然而,传统的中药治疗通常是通过口服或灌肠的方式进行,口服制剂对人体副作用较大,且中药的苦味不易被人们接受,灌肠给药方式也会给病人带来痛苦。因此,开发可直接外用的中药清洗液来治疗溃疡性直肠炎具有极其重要的临床意义。
发明内容
鉴于现有技术的不足,本发明提供一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法。具有方便易行、疗效显著、安全性高等优点,有望成为治疗直肠炎的新突破点。
本发明技术方案如下:
一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液,所述中药清洗液由以下重量份原料制成:22-33份滇白芷果、14-20份五倍子、12-16份水龙胆草、9-13份侧柏叶、10-14份黄柏、10-13份地榆炭、4-6份血竭、2-4份冰片。
优选的,所述中药清洗液由以下重量份原料制成:23份滇白芷果、20份五倍子、16份水龙胆草、10份侧柏叶、11份黄柏、12份地榆炭、5份血竭、3份冰片。
另一方面,本发明提供所述的中药清洗液的制备方法,包括以下步骤:将各原料混合,加水煎煮,过滤,弃滤渣,得清洗液。
优选的,原料与水按料液比100g/1000mL的比例混合。
优选的,煎煮至少120分钟。
进一步的说明:
各中药原料信息如下:
滇白芷果,中药名。为伞形科植物糙叶独活Heracleum scabridum Franch.的果实。
白芷,中药名。为伞形科当归属植物白芷Angelica dahurica(Fisch.ex Hoffm)Benth.et Hook.f.的根。
五倍子,中药名。为漆树科盐肤木属植物盐肤木Rhus chinensis Mill.叶上的虫瘿。
地榆炭,中药名。为蔷薇科地榆属植物地榆Sanguisorba officinalis L.的根的炮制加工品。
侧柏叶,中药名。为柏科侧柏属植物侧柏Platycladus orientalis(L.)franco的嫩枝叶。
黄柏,中药名。为芸香科黄檗属植物黄皮树Phellodendron chinense Schneid.的干燥树皮。
血竭,中药名。为棕榈科黄藤属植物麒麟竭Daemonorops draco Bl.的果实渗出的树脂经加工制成。
冰片,中药名。为龙脑香科龙脑香属植物龙脑香Dryobalanops aromaticaGaertn.f.树脂加工品。
水龙胆草,中药名。为唇形科植物腺花香茶菜Rabdosiaadenantha(Diels)Hara的茎叶。
白及,中药名。为兰科白及属植物白及Bletillastriata(Thunb.)Reichb.f.的块茎。
鸡冠花,中药名。为苋科青葙属植物鸡冠花Celosia cristata L.的干燥花序。
与现有技术相比,本发明的有益成果在于:
本发明提供了一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液,该清洗液由滇白芷果、五倍子、水龙胆草、侧柏叶、黄柏、地榆炭、血竭、冰片等中药煎煮制成,该中药清洗液可以加快直肠溃疡的愈合,修复直肠黏膜,改善直肠黏膜通透性,具有治疗溃疡性直肠炎的明显效果。
本发明所提供的中药清洗液为外用产品,无需口服,降低了中药的毒性风险。使用方法简便,仅需通过熏蒸坐浴的方式即可达到治疗溃疡性直肠炎的效果。
本发明中所述的清洗液对溃疡性直肠炎具有良好的治疗效果,治疗周期短,安全性高。同时,本发明的清洗液制备工艺简单,成本低廉,易于推广应用。
具体实施方式
为使本领域技术人员更好的理解本发明技术内容,下面结合具体实施例对本发明做进一步的说明。
以下实施例仅仅是本发明的一种具体实施方式,不应当被视为对本发明的限制。
实施例1:
中药清洗液的制备:将22克滇白芷果、18克五倍子、16克水龙胆草、9克侧柏叶、14克黄柏、13克地榆炭、6克血竭、2克冰片加入1000毫升水中,煎煮120分钟,滤去渣即可得到清洗液。
将清洗液应用于治疗溃疡性直肠炎,每天使用两次,将中药清洗液加热至40-50℃左右,熏蒸坐浴,连续使用两周,治疗效果显著。在使用过程中,需注意用清水冲洗***及周围部位,保持干燥清洁。
实施例2:
中药清洗液的制备:将33克滇白芷果、14克五倍子、12克水龙胆草、13克侧柏叶、10克黄柏、10克地榆炭、4克血竭、4克冰片加入1000毫升水中,煎煮120分钟,滤去渣即可得到清洗液。
将清洗液应用于治疗溃疡性直肠炎,每天使用两次,将中药清洗液加热至40-50℃左右,熏蒸坐浴,连续使用两周,治疗效果显著。在使用过程中,需注意用清水冲洗***及周围部位,保持干燥清洁。
实施例3:
中药清洗液的制备:将23克滇白芷果、20克五倍子、16克水龙胆草、10克侧柏叶、11克黄柏、12克地榆炭、5克血竭、3克冰片加入1000毫升水中,煎煮120分钟,滤去渣即可得到清洗液。
将清洗液应用于治疗溃疡性直肠炎,每天使用两次,将中药清洗液加热至40-50℃左右,熏蒸坐浴30分钟左右,连续使用两周,治疗效果显著。在使用过程中,需注意用清水冲洗***及周围部位,保持干燥清洁。
对比例1:
此例中,选择其它具有去腐生肌、收敛止血、清热燥湿功效的中药。
清洗液由23克白芷、20克鸡冠花、16克黄连、10克白及、11克黄柏、12克地榆炭、5克血竭、3克冰片制成。制备方法是将这些药材混合后,加入1000毫升水中,煎煮120分钟,滤去渣,得到清洗液。
其使用方法与其他实施例相同。
对比例2:
此例中清洗液中药成分与实施例3相同,区别是各成分的主次关系有所调整。
中药清洗液的制备:将15克滇白芷果、24克五倍子、12克水龙胆草、18克侧柏叶、11克黄柏、12克地榆炭、5克血竭、3克冰片加入1000毫升水中,煎煮120分钟,滤去渣即可得到清洗液。
其使用方法与其他实施例相同。
产品使用效果:
1.实验对象:选取实验室大鼠,体重230-250g;
2.构建动物病理模型:大鼠禁食24h后,麻醉并肠腔清粪,将浸沾10%冰醋酸的棉花纸由***送入直肠内,3-5分钟后取出。大鼠苏醒后喂食饮水。间隔2d重复处理一次,连续3次。术后1周观察大便性状,随机处死2只大鼠观察直肠形态及组织学炎症改变,符合溃疡性直肠炎表现说明建模成功。
3.将建模成功的大鼠分为实验组和模型组,实验组给药处理,模型组不给药正常喂食饮水。同时设置空白对照组,即未建模的正常小鼠,正常喂食饮水,不给药。
给药方式:将药液加热至40℃,对准大鼠***处熏蒸20分钟,每天早晚各1次,连续7天;
4.检测方法:
肠黏膜通透性测定:禁食8h,取2ml乳果糖和甘露醇混合液(含乳果糖120mg+甘露醇80mg),用灌胃器***大鼠食管上端缓慢灌注。收集12h内的尿液标本。
高效液相色谱法检测其尿液中的乳果糖、甘露醇。色谱柱:Dionex CarbonPacPA1。测定大鼠尿液中乳果糖(L)与甘露醇(M)***率(L/M)比值,反映肠黏膜屏障的变化情况,评估大鼠肠道通透性的变化,以评估清洗液的治疗效果。
5.实验结果:见表1。
表1
肠道通透性增加的程度提示肠黏膜屏障功能损伤的轻重。肠道通透性可以通过乳果糖/甘露醇比值L/M来评估。与空白对照组相比,模型组L/M值显著增加,说明其肠道黏膜通透性增加,肠黏膜受损,其他各组的L/M值也高于空白对照组但显著低于模型组,说明实验组给药处理后,直肠损伤情况有所缓解。与给药对比例样品相比,给药实施例3的样品时,L/M值显著降低,提示本发明产品治疗效果良好。各组L/M值之间均达到极显著差异(P<0.01)。
以上所述仅为本发明的部分实施例而已,并不用限制本发明,凡在本发明的精神和原则之内,所做的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (5)
1.一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液,其特征在于,所述中药清洗液由以下重量份原料制成:22-33份滇白芷果、14-20份五倍子、12-16份水龙胆草、9-13份侧柏叶、10-14份黄柏、10-13份地榆炭、4-6份血竭、2-4份冰片。
2.根据权利要求1所述的中药清洗液,其特征在于,所述中药清洗液由以下重量份原料制成:23份滇白芷果、20份五倍子、16份水龙胆草、10份侧柏叶、11份黄柏、12份地榆炭、5份血竭、3份冰片。
3.权利要求1所述的中药清洗液的制备方法,其特征在于,包括以下步骤:将各原料混合,加水煎煮,过滤,弃滤渣,得清洗液。
4.根据权利要求3所述的制备方法,其特征在于,原料与水按料液比100g/1000mL的比例混合。
5.根据权利要求3所述的制备方法,其特征在于,煎煮至少120分钟。
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