CN116688041A - 一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 - Google Patents
一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 Download PDFInfo
- Publication number
- CN116688041A CN116688041A CN202310794962.8A CN202310794962A CN116688041A CN 116688041 A CN116688041 A CN 116688041A CN 202310794962 A CN202310794962 A CN 202310794962A CN 116688041 A CN116688041 A CN 116688041A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- traditional chinese
- water
- cleaning liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000004140 cleaning Methods 0.000 title claims abstract description 40
- 239000003814 drug Substances 0.000 title claims abstract description 37
- 206010036774 Proctitis Diseases 0.000 title claims abstract description 21
- 239000007788 liquid Substances 0.000 title claims abstract description 21
- 206010036783 Proctitis ulcerative Diseases 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 230000000740 bleeding effect Effects 0.000 title claims abstract description 9
- 238000005469 granulation Methods 0.000 title claims abstract description 9
- 230000003179 granulation Effects 0.000 title claims abstract description 9
- 230000001338 necrotic effect Effects 0.000 title claims abstract description 9
- 230000001737 promoting effect Effects 0.000 title claims abstract description 9
- 238000001035 drying Methods 0.000 title claims abstract description 8
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 15
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229940116229 borneol Drugs 0.000 claims abstract description 15
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 15
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 15
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 14
- 241000972673 Phellodendron amurense Species 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 13
- 235000008282 Sanguisorba officinalis Nutrition 0.000 claims abstract description 12
- 239000003610 charcoal Substances 0.000 claims abstract description 12
- 239000009136 dragon's blood Substances 0.000 claims abstract description 12
- 235000008291 Poterium sanguisorba Nutrition 0.000 claims abstract description 11
- 240000002924 Platycladus orientalis Species 0.000 claims abstract description 9
- 240000003152 Rhus chinensis Species 0.000 claims abstract description 8
- 235000014220 Rhus chinensis Nutrition 0.000 claims abstract description 8
- 240000004064 Poterium sanguisorba Species 0.000 claims abstract 3
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 241001071795 Gentiana Species 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 4
- 238000001914 filtration Methods 0.000 claims description 3
- 239000012530 fluid Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 12
- 241000700159 Rattus Species 0.000 description 12
- 244000186071 dragons blood palm Species 0.000 description 10
- 244000173853 Sanguisorba officinalis Species 0.000 description 9
- 210000000436 anus Anatomy 0.000 description 8
- 210000001519 tissue Anatomy 0.000 description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 5
- 229930195725 Mannitol Natural products 0.000 description 5
- 240000000905 Nymphoides indica Species 0.000 description 5
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 5
- 229960000511 lactulose Drugs 0.000 description 5
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 5
- 235000010355 mannitol Nutrition 0.000 description 5
- 239000000594 mannitol Substances 0.000 description 5
- 210000004347 intestinal mucosa Anatomy 0.000 description 4
- 230000003870 intestinal permeability Effects 0.000 description 4
- 241000561734 Celosia cristata Species 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
- 241000125175 Angelica Species 0.000 description 2
- 241000208173 Apiaceae Species 0.000 description 2
- 241001313857 Bletilla striata Species 0.000 description 2
- 235000001287 Guettarda speciosa Nutrition 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 210000001520 comb Anatomy 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 230000004673 intestinal mucosal barrier function Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- HNSDLXPSAYFUHK-UHFFFAOYSA-N 1,4-bis(2-ethylhexyl) sulfosuccinate Chemical compound CCCCC(CC)COC(=O)CC(S(O)(=O)=O)C(=O)OCC(CC)CCCC HNSDLXPSAYFUHK-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 241001254604 Angelica pubescens Species 0.000 description 1
- 241000233788 Arecaceae Species 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 241001313855 Bletilla Species 0.000 description 1
- 244000247747 Coptis groenlandica Species 0.000 description 1
- 235000002991 Coptis groenlandica Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000218691 Cupressaceae Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 240000005636 Dryobalanops aromatica Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000006464 Fibraurea tinctoria Species 0.000 description 1
- 244000111489 Gardenia augusta Species 0.000 description 1
- 241000594394 Hedyotis Species 0.000 description 1
- 241000554714 Heracleum scabridum Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241001646826 Isodon rubescens Species 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 241000972672 Phellodendron Species 0.000 description 1
- 241001079007 Phellodendron chinense Species 0.000 description 1
- 241000736211 Platycladus Species 0.000 description 1
- 206010036772 Proctalgia Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010072587 Rectal injury Diseases 0.000 description 1
- 241000208225 Rhus Species 0.000 description 1
- 235000004789 Rosa xanthina Nutrition 0.000 description 1
- 241000220222 Rosaceae Species 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 240000003243 Thuja occidentalis Species 0.000 description 1
- 235000008109 Thuja occidentalis Nutrition 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000012362 glacial acetic acid Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 210000005027 intestinal barrier Anatomy 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 239000009286 sanguis draxonis Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/739—Sanguisorba (burnet)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Insects & Arthropods (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明涉及一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法，本发明中所述的清洗液由22‑33份滇白芷果、14‑20份五倍子、12‑16份水龙胆草、9‑13份侧柏叶、10‑14份黄柏、10‑13份地榆炭、4‑6份血竭、2‑4份冰片制成，可用于治疗溃疡性直肠炎，其治疗效果优良，安全性高。同时，本发明的清洗液制备工艺简单，成本低廉，易于推广应用。
Description
技术领域
本发明涉及一种中药清洗液，特别涉及一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法。
背景技术
直肠炎是指直肠部位发生炎症的疾病。溃疡性直肠炎主要发生在直肠黏膜及黏膜下层，其特点是肠黏膜屏障受损、肠道通透性增加以及溃疡形成。临床上常见的症状包括排便次数增多、腹泻、腹痛、伴有黏液脓血的大便、***疼痛和瘙痒等。该疾病的病程较长，易复发，给患者的生活和心理造成了极大的困扰。
传统中药治疗逐渐成为溃疡性直肠炎的替代治疗方法。多项临床研究表明，一些中药如当归、白术、栀子、黄柏等对溃疡性直肠炎有一定的治疗效果。然而，传统的中药治疗通常是通过口服或灌肠的方式进行，口服制剂对人体副作用较大，且中药的苦味不易被人们接受，灌肠给药方式也会给病人带来痛苦。因此，开发可直接外用的中药清洗液来治疗溃疡性直肠炎具有极其重要的临床意义。
发明内容
鉴于现有技术的不足，本发明提供一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法。具有方便易行、疗效显著、安全性高等优点，有望成为治疗直肠炎的新突破点。
本发明技术方案如下：
一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液，所述中药清洗液由以下重量份原料制成：22-33份滇白芷果、14-20份五倍子、12-16份水龙胆草、9-13份侧柏叶、10-14份黄柏、10-13份地榆炭、4-6份血竭、2-4份冰片。
优选的，所述中药清洗液由以下重量份原料制成：23份滇白芷果、20份五倍子、16份水龙胆草、10份侧柏叶、11份黄柏、12份地榆炭、5份血竭、3份冰片。
另一方面，本发明提供所述的中药清洗液的制备方法，包括以下步骤：将各原料混合，加水煎煮，过滤，弃滤渣，得清洗液。
优选的，原料与水按料液比100g/1000mL的比例混合。
优选的，煎煮至少120分钟。
进一步的说明：
各中药原料信息如下：
滇白芷果，中药名。为伞形科植物糙叶独活Heracleum scabridum Franch.的果实。
白芷，中药名。为伞形科当归属植物白芷Angelica dahurica(Fisch.ex Hoffm)Benth.et Hook.f.的根。
五倍子，中药名。为漆树科盐肤木属植物盐肤木Rhus chinensis Mill.叶上的虫瘿。
地榆炭，中药名。为蔷薇科地榆属植物地榆Sanguisorba officinalis L.的根的炮制加工品。
侧柏叶，中药名。为柏科侧柏属植物侧柏Platycladus orientalis(L.)franco的嫩枝叶。
黄柏，中药名。为芸香科黄檗属植物黄皮树Phellodendron chinense Schneid.的干燥树皮。
血竭，中药名。为棕榈科黄藤属植物麒麟竭Daemonorops draco Bl.的果实渗出的树脂经加工制成。
冰片，中药名。为龙脑香科龙脑香属植物龙脑香Dryobalanops aromaticaGaertn.f.树脂加工品。
水龙胆草，中药名。为唇形科植物腺花香茶菜Rabdosiaadenantha(Diels)Hara的茎叶。
白及，中药名。为兰科白及属植物白及Bletillastriata(Thunb.)Reichb.f.的块茎。
鸡冠花，中药名。为苋科青葙属植物鸡冠花Celosia cristata L.的干燥花序。
与现有技术相比，本发明的有益成果在于：
本发明提供了一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液，该清洗液由滇白芷果、五倍子、水龙胆草、侧柏叶、黄柏、地榆炭、血竭、冰片等中药煎煮制成，该中药清洗液可以加快直肠溃疡的愈合，修复直肠黏膜，改善直肠黏膜通透性，具有治疗溃疡性直肠炎的明显效果。
本发明所提供的中药清洗液为外用产品，无需口服，降低了中药的毒性风险。使用方法简便，仅需通过熏蒸坐浴的方式即可达到治疗溃疡性直肠炎的效果。
本发明中所述的清洗液对溃疡性直肠炎具有良好的治疗效果，治疗周期短，安全性高。同时，本发明的清洗液制备工艺简单，成本低廉，易于推广应用。
具体实施方式
为使本领域技术人员更好的理解本发明技术内容，下面结合具体实施例对本发明做进一步的说明。
以下实施例仅仅是本发明的一种具体实施方式，不应当被视为对本发明的限制。
实施例1：
中药清洗液的制备：将22克滇白芷果、18克五倍子、16克水龙胆草、9克侧柏叶、14克黄柏、13克地榆炭、6克血竭、2克冰片加入1000毫升水中，煎煮120分钟，滤去渣即可得到清洗液。
将清洗液应用于治疗溃疡性直肠炎，每天使用两次，将中药清洗液加热至40-50℃左右，熏蒸坐浴，连续使用两周，治疗效果显著。在使用过程中，需注意用清水冲洗***及周围部位，保持干燥清洁。
实施例2：
中药清洗液的制备：将33克滇白芷果、14克五倍子、12克水龙胆草、13克侧柏叶、10克黄柏、10克地榆炭、4克血竭、4克冰片加入1000毫升水中，煎煮120分钟，滤去渣即可得到清洗液。
将清洗液应用于治疗溃疡性直肠炎，每天使用两次，将中药清洗液加热至40-50℃左右，熏蒸坐浴，连续使用两周，治疗效果显著。在使用过程中，需注意用清水冲洗***及周围部位，保持干燥清洁。
实施例3：
中药清洗液的制备：将23克滇白芷果、20克五倍子、16克水龙胆草、10克侧柏叶、11克黄柏、12克地榆炭、5克血竭、3克冰片加入1000毫升水中，煎煮120分钟，滤去渣即可得到清洗液。
将清洗液应用于治疗溃疡性直肠炎，每天使用两次，将中药清洗液加热至40-50℃左右，熏蒸坐浴30分钟左右，连续使用两周，治疗效果显著。在使用过程中，需注意用清水冲洗***及周围部位，保持干燥清洁。
对比例1：
此例中，选择其它具有去腐生肌、收敛止血、清热燥湿功效的中药。
清洗液由23克白芷、20克鸡冠花、16克黄连、10克白及、11克黄柏、12克地榆炭、5克血竭、3克冰片制成。制备方法是将这些药材混合后，加入1000毫升水中，煎煮120分钟，滤去渣，得到清洗液。
其使用方法与其他实施例相同。
对比例2：
此例中清洗液中药成分与实施例3相同，区别是各成分的主次关系有所调整。
中药清洗液的制备：将15克滇白芷果、24克五倍子、12克水龙胆草、18克侧柏叶、11克黄柏、12克地榆炭、5克血竭、3克冰片加入1000毫升水中，煎煮120分钟，滤去渣即可得到清洗液。
其使用方法与其他实施例相同。
产品使用效果：
1.实验对象：选取实验室大鼠，体重230-250g；
2.构建动物病理模型：大鼠禁食24h后，麻醉并肠腔清粪，将浸沾10％冰醋酸的棉花纸由***送入直肠内，3-5分钟后取出。大鼠苏醒后喂食饮水。间隔2d重复处理一次，连续3次。术后1周观察大便性状，随机处死2只大鼠观察直肠形态及组织学炎症改变，符合溃疡性直肠炎表现说明建模成功。
3.将建模成功的大鼠分为实验组和模型组，实验组给药处理，模型组不给药正常喂食饮水。同时设置空白对照组，即未建模的正常小鼠，正常喂食饮水，不给药。
给药方式：将药液加热至40℃，对准大鼠***处熏蒸20分钟，每天早晚各1次，连续7天；
4.检测方法：
肠黏膜通透性测定：禁食8h，取2ml乳果糖和甘露醇混合液(含乳果糖120mg+甘露醇80mg)，用灌胃器***大鼠食管上端缓慢灌注。收集12h内的尿液标本。
高效液相色谱法检测其尿液中的乳果糖、甘露醇。色谱柱:Dionex CarbonPacPA1。测定大鼠尿液中乳果糖(L)与甘露醇(M)***率(L/M)比值，反映肠黏膜屏障的变化情况，评估大鼠肠道通透性的变化，以评估清洗液的治疗效果。
5.实验结果：见表1。
表1
肠道通透性增加的程度提示肠黏膜屏障功能损伤的轻重。肠道通透性可以通过乳果糖/甘露醇比值L/M来评估。与空白对照组相比，模型组L/M值显著增加，说明其肠道黏膜通透性增加，肠黏膜受损，其他各组的L/M值也高于空白对照组但显著低于模型组，说明实验组给药处理后，直肠损伤情况有所缓解。与给药对比例样品相比，给药实施例3的样品时，L/M值显著降低，提示本发明产品治疗效果良好。各组L/M值之间均达到极显著差异(P＜0.01)。
以上所述仅为本发明的部分实施例而已，并不用限制本发明，凡在本发明的精神和原则之内，所做的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (5)
1.一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液，其特征在于，所述中药清洗液由以下重量份原料制成：22-33份滇白芷果、14-20份五倍子、12-16份水龙胆草、9-13份侧柏叶、10-14份黄柏、10-13份地榆炭、4-6份血竭、2-4份冰片。
2.根据权利要求1所述的中药清洗液，其特征在于，所述中药清洗液由以下重量份原料制成：23份滇白芷果、20份五倍子、16份水龙胆草、10份侧柏叶、11份黄柏、12份地榆炭、5份血竭、3份冰片。
3.权利要求1所述的中药清洗液的制备方法，其特征在于，包括以下步骤：将各原料混合，加水煎煮，过滤，弃滤渣，得清洗液。
4.根据权利要求3所述的制备方法，其特征在于，原料与水按料液比100g/1000mL的比例混合。
5.根据权利要求3所述的制备方法，其特征在于，煎煮至少120分钟。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310794962.8A CN116688041A (zh) | 2023-06-30 | 2023-06-30 | 一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310794962.8A CN116688041A (zh) | 2023-06-30 | 2023-06-30 | 一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116688041A true CN116688041A (zh) | 2023-09-05 |
Family
ID=87831145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310794962.8A Pending CN116688041A (zh) | 2023-06-30 | 2023-06-30 | 一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116688041A (zh) |
-
2023
- 2023-06-30 CN CN202310794962.8A patent/CN116688041A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP4147708A1 (en) | Traditional chinese medicine composition for treating novel coronavirus pneumonia, preparation method, detection method, and use thereof | |
| CN1621082A (zh) | 治疗痤疮的中药组合物 | |
| WO2015010498A1 (zh) | 快速清理身体代谢毒素的天然草本组合物 | |
| CN101584759B (zh) | 一种纯植物来源的药物组合物及其应用 | |
| CN102048910A (zh) | 金银花口服液 | |
| CN113876688A (zh) | 抑菌养护洗液及其制备方法 | |
| JP2535559B2 (ja) | 魚類のせっそう病の予防及び治療剤 | |
| CN101496850A (zh) | 一种用于治疗便秘的药物组合及其制备方法 | |
| WO2003075937A1 (fr) | Preparation chinoise servant a traiter l'enterocolite ulcereuse et son procede de preparation | |
| CN116688041A (zh) | 一种用于去腐生肌、收敛止血、清热燥湿治疗溃疡性直肠炎的中药清洗液及其制备方法 | |
| CN101919919B (zh) | 腹可安分散片及其制备方法 | |
| CN101167843B (zh) | 兽用茵栀黄注射液的制备方法 | |
| Sharma | MEDICAL ETHNOBOTANY IN THE svALIK RANGE OF THE HIMALAYAs | |
| CN100417410C (zh) | 治疗胃肠型暑湿感冒的药物及其制备方法 | |
| CN104491456A (zh) | 风湿性膝关节炎除痹通络膏及制备 | |
| CN101549140B (zh) | 治疗艾滋病的中药组合物及其制备方法 | |
| CN110772623A (zh) | 治疗***的中药 | |
| CN104474430A (zh) | 一种治疗肝肾阴虚型霉菌性***炎的中药及制备方法 | |
| CN110870894A (zh) | 一种治疗腹泻的中药组合物 | |
| CN104547462B (zh) | 一种润肠通便的中药组合物及其制备方法 | |
| CN1170559C (zh) | 清肝解毒胶囊及其制备方法 | |
| CN115645508B (zh) | 一种用于宫颈疾病的外用中药组合物和外用制剂及其制备方法 | |
| CN110251564B (zh) | 一种治疗痛风关节炎的外用药及其制备方法 | |
| CN108904649B (zh) | 一种治疗***的中药及其制备方法 | |
| CN114533835B (zh) | 一种具有芳香、祛风利湿功效的药物及其制备方法 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |