CN116672597A - Ventricular assist device for cardiac surgery - Google Patents
Ventricular assist device for cardiac surgery Download PDFInfo
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- CN116672597A CN116672597A CN202310790274.4A CN202310790274A CN116672597A CN 116672597 A CN116672597 A CN 116672597A CN 202310790274 A CN202310790274 A CN 202310790274A CN 116672597 A CN116672597 A CN 116672597A
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- swing rod
- assist device
- ventricular assist
- adjusting cavity
- microspheres
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
- A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
- A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
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- Mechanical Engineering (AREA)
- Hematology (AREA)
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- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
Abstract
The invention discloses a heart chamber auxiliary device for cardiac surgery, which comprises: the detection support comprises a support body and an adjusting cavity arranged in the support body, a semipermeable membrane is arranged on the end face of the support body, microspheres are arranged in the adjusting cavity and can move in the adjusting cavity, and the microspheres are used for driving the embolism processing mechanism; the embolism treatment mechanism comprises a plurality of swinging rods, one ends of the swinging rods extend into the adjusting cavity, and the other free ends face to the inner ring position of the detection bracket; according to the invention, the annular detection support is arranged on the blood channel of the ventricular assist device, and the osmotic pressure change is converted into the change of the liquid flow rate and the internal pressure in the detection support through the influence of blood clot and thrombus formation on blood osmotic pressure and the arrangement of the semipermeable membrane, so that the microspheres in the adjusting cavity can perform targeted movement impact under different conditions to drive the swing rod to perform radial swing, thereby influencing the thrombus formation.
Description
Technical Field
The invention relates to the field of medical instruments or cardiac surgery, in particular to a ventricular assist device for cardiac surgery.
Background
The ventricular assist device is composed of a connecting pipeline, a one-way valve or a prosthetic heart valve and a blood flow driving device. When in use, the heart chamber of a patient is reserved, the patient is inserted into the heart and/or a large blood vessel by a pipeline, and the auxiliary circulation is carried out by replacing the heart by a blood flow driving device arranged in the body and/or the body, and the device is mainly used for patients with left heart, right heart or double-ventricle functional failure after open-heart surgery or myocardial infarction and patients waiting for heart transplantation.
When current ventricular assist devices are implanted and used, blood clots may appear as blood passes through the VAD, which may slow or obstruct blood flow, causing strokes, heart attacks, or problems with the device; in addition, proliferation of a site such as a vessel, which is referred to as "endothelial cell proliferation" or "intimal hyperplasia", may lead to thrombus formation, by which is meant proliferation of cells in the vessel wall to form a thin film, covering the vessel or other components, which may lead to clotting of blood in the vessel and thrombus formation.
To reduce proliferation, drug therapy is commonly used to prevent and maintain vascular patency, including the use of anticoagulants and antiplatelet drugs, such as aspirin and heparin, to reduce thrombosis; in addition, the method for removing thrombus also comprises the following steps depending on factors such as the position, size and form of thrombus: anticoagulation treatment: this is a non-surgical treatment that prevents thrombosis and expansion by taking medications to dilute blood. This treatment is very effective in the early stages of thrombosis; mechanical lithotripsy (Thrombolysis): this method is a mechanical method that helps to restore blood flow to normal by using instruments or drugs to break down or break up the thrombus, and is applicable to smaller thrombi and shallower venous thrombi; thrombi aspiration and mechanical thrombolysis (Thrombectomy): this procedure is a surgical treatment that removes the thrombus from the vessel by using some aspiration or mechanical means. This method is applicable to larger thrombi and deeper venous thrombi.
In order to prevent and reduce thrombosis, other long-acting and stable measures are required to promote blood flow and prevent blood stasis, so that the risk of thrombosis is reduced, and frequent drug injection treatment of doctors and patients is avoided.
Disclosure of Invention
The invention overcomes the defects of the prior art, and provides a heart chamber auxiliary device for cardiac surgery, which converts osmotic pressure change into change of liquid flow velocity and internal pressure in a detection bracket through the influence of blood clot and thrombus formation on blood osmotic pressure and the arrangement of a semipermeable membrane, so that microspheres in an adjusting cavity can perform targeted movement impact under different conditions to drive a swing rod to perform radial swing, thereby influencing thrombus formation.
In order to achieve the above purpose, the invention adopts the following technical scheme: a ventricular assist device for cardiac surgery, comprising: detect the support and set up embolic processing mechanism on the detection support, its characterized in that:
the detection support adopts a radial airtight annular structure, can be replaced or added on a blood passage of an existing ventricular assist device, comprises a support body, an adjusting cavity and microspheres, wherein the adjusting cavity and the microspheres are arranged in the support body, a semipermeable membrane is arranged on the end face of the support body, the adjusting cavity is communicated with an external space through the semipermeable membrane, the microspheres are arranged in the adjusting cavity and can move in the adjusting cavity, and the microspheres are used for driving the embolism treatment mechanism; according to the invention, by utilizing the change of blood osmotic pressure during thrombus formation, the liquid flowing into the cavity plays a role in changing the driving force on the microspheres, and when the osmotic pressure outside the cavity is regulated to be improved, the flow speed and the flow rate of the liquid passing through the semipermeable membrane are increased, so that the microspheres are accelerated to move; when osmotic pressure decreases, the flow rate and flow of fluid through the semipermeable membrane decreases, and the amplitude and frequency of microsphere movement decreases.
The embolism treatment mechanism comprises a plurality of swinging rods, the swinging rods are in semi-movable connection with the bracket body, the tail ends of the swinging rods extend into the adjusting cavity, and the other free ends of the swinging rods face to the inner ring position of the detection bracket; the swing rod stretches into one end of the adjusting cavity to be in contact with the microspheres, the microspheres can be driven by liquid penetrating through the semipermeable membrane to swing, and after the microspheres are in contact with the swing rod, the swing rod is pushed to swing in the radial direction of the swing rod, so that the blood flow rate is enhanced, thrombus formation is avoided through acceleration of local blood flow, and the thrombus formation is started to form a part block which is not completely plugged, the part block can be pushed through swing, further deterioration is avoided, and even the part block is broken up and decomposed under a better condition.
In a preferred embodiment of the present invention, the detection support is disposed at a position of a body or a valve of the ventricular assist device, and is close to the ventricular assist device, so as to effectively target to blood clots and accelerate blood flow; and the annular structure is arranged on the body or the valve, so that the additional structure is avoided, and the blocking influence exceeding the existing ventricular assist device is avoided.
In a preferred embodiment of the present invention, the swing rod extends out of the middle section of the rod body of the support body, and is provided with at least one elastic section, and the swing rod can be folded along the direction of the blood flow direction through the free end of the elastic section, so that the formed blood clot which cannot be broken or digested passes through, and the blood clot is prevented from further expanding by slow release of the medicine, and the elastic section can also provide a rebound effect, so that the swing rod returns to the original position.
In a preferred embodiment of the present invention, the elastic section is made of rubber.
In a preferred embodiment of the present invention, a placing groove is formed at one end of the swing rod extending into the adjusting cavity, and is used for carrying the microsphere, the microsphere is limited to move in the placing groove, the placing groove preferably adopts a semi-cladding mode, that is, the microsphere can be influenced by the liquid flow rate of the semipermeable membrane, and is ensured to be kept in the placing groove, the swing rod is enabled to swing through high-frequency impact of the placing groove, so that the local blood flow rate of the swing rod is improved, in some embodiments, the swing rod can also be matched and limited through the placing groove and the inner wall of the adjusting cavity, the distance between the placing groove and the inner wall of the adjusting cavity is smaller than the radius of the microsphere, so as to limit the microsphere, preferably, the microsphere corresponds to the swing rod one by one, and the swing rod can be distributed at equal intervals in the radial direction of the annular structure.
In a preferred embodiment of the invention, the microsphere is made of silica gel or rubber, so that a certain rebound resilience can be provided, and the most important function is to utilize the deformation of the microsphere to perform force unloading buffering, so that collision and vibration between the hard microsphere and the hard swing rod are avoided, and the service life of the device is reduced or the tightness is influenced.
In a preferred embodiment of the present invention, the interior of the microsphere is hollow for weight reduction, and in other embodiments, the surface of the microsphere is provided with through holes to further enhance the elastic buffering capacity.
In a preferred embodiment of the present invention, the semipermeable membrane is fixedly connected with the support body, the semipermeable membrane is obliquely arranged, and the oblique extending direction and the blood flow direction are acute angles, so that impurities or blood clots can be prevented from accumulating at the semipermeable membrane, and the osmotic pressure difference can be ensured to be directly and accurately fed back to the inside of the regulating cavity and the action of the microsphere.
In addition, also be provided with the semipermeable membrane in one side of blood flow direction back way position, its inclination is parallel with wanting the front way semipermeable membrane, can reduce the blood backward flow infiltration of back way position, reduces the impact of hedging.
In a preferred embodiment of the present invention, two protrusions are disposed on the surface of the swing rod, and are respectively located at two sides of the inner wall of the support body, so as to axially limit the swing rod, and simultaneously ensure radial swinging of the swing rod, and limit the swing rod through the disposition of the protrusions at two sides, and further, a sealing structure, such as a rubber sheet, is disposed between the protrusions and the support body.
In a preferred embodiment of the invention, the surface of the swing rod is provided with spiral convex lines, so that the swing rod has better breaking-up capability when colliding with blood clots through a surface structure.
In a preferred embodiment of the invention, a slow-release drug is arranged in the swing rod, and the surface of the swing rod is hollowed out and is used for providing a drug release window.
In a preferred embodiment of the invention, the diameter of the slow-release drug is smaller than the inner diameter of the swing rod, the slow-release drug can collide with the inner wall of the swing rod so as to accelerate the release of the slow-release drug, and under the influence of high osmotic pressure in the process of thrombus formation or to be formed, the accelerated swing of the microsphere can release the drug more quickly so as to form targeted control of the drug release amount.
The invention solves the defects existing in the background technology, and has the following beneficial effects:
(1) According to the invention, the annular detection support is arranged on the blood channel of the ventricular assist device, and through the influence of blood clot and thrombus formation on blood osmotic pressure and the arrangement of the semipermeable membrane, osmotic pressure change is converted into change of liquid flow velocity and internal pressure in the detection support, so that microspheres in the adjusting cavity are subjected to targeted moving impact under different conditions, the swing rod is driven to swing radially, on one hand, the local blood flow velocity can be accelerated through the swing of the part of the swing rod extending out of the support body, thereby further thrombus formation is avoided through the acceleration of the flow velocity, on the other hand, medicine in the swing rod is diffused and released through the swing, and the release speed can be increased along with the swing amplitude and frequency, namely, more medicine release can be carried out in the face of more serious blood clot conditions.
(2) The microsphere is preferably of a hollow structure, not only can receive thrust from liquid through the surface of the microsphere, but also the liquid passing through the semipermeable membrane flows from a high osmotic pressure position formed by thrombus to an inner low osmotic pressure position, and the osmotic pressure difference is larger, so that the osmotic speed is larger, the microsphere is prepared from an elastic material after collision so as to avoid vibration, and the buffer capacity of the microsphere is increased to avoid excessive vibration by the arrangement of the hollow structure, and the weight reduction effect is achieved, so that the influence of external thrust is more direct and effective, and the sensitivity to the change of the flow speed of the inner liquid is ensured.
(3) According to the invention, the limit structure is arranged at one end of the swing rod in the adjusting cavity, and the microspheres can act on the swing rod in a one-to-one correspondence manner through limiting the microspheres, so that the confusing condition of mutual collision is avoided, and in a limited space, the microspheres can also apply force to the swing rod more efficiently at high frequency, so that the swing rod can swing efficiently; the upper segment structure of the oscillating bar outside the adjusting cavity is connected with a plurality of segments through elastic materials, so that the oscillating bar outside the adjusting cavity can be bent, and the situation that blood clots which cannot be decomposed and scattered are blocked at the position of the oscillating bar and more serious embolism is caused is avoided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required to be used in the embodiments or the description of the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments described in the present invention, and other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art;
FIG. 1 is a perspective view of a preferred embodiment of the present invention;
FIG. 2 is a partial cross-sectional view of a preferred embodiment of the present invention;
in the figure: 1. detecting a bracket; 2. a plug processing mechanism; 20. adjusting the cavity; 21. a semipermeable membrane; 22. a microsphere; 23. swing rod; 231. a placement groove; 232. and a bump.
Detailed Description
Reference to "an embodiment," "one embodiment," or "other embodiments" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least some, but not necessarily all embodiments, as may be apparent to those skilled in the art from consideration of the embodiments disclosed herein, and all other embodiments are intended to be within the scope of protection of the present invention.
In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. indicate orientations or positional relationships based on the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the scope of the present invention.
A ventricular assist device for cardiac surgery, comprising: the detection support 1 and the embolism processing mechanism 2 arranged on the detection support 1, wherein the detection support 1 adopts a radial closed annular structure, and can be replaced or added on a blood passage of an existing ventricular assist device, the detection support 1 comprises a support body, an adjusting cavity 20 and microspheres 22, the adjusting cavity 20 and the microspheres are arranged in the support body, a semipermeable membrane 21 is arranged on the end face of the support body, the adjusting cavity 20 is communicated with an external space through the semipermeable membrane 21, the microspheres 22 are arranged in the adjusting cavity 20, the microspheres 22 can move in the adjusting cavity 20, and the microspheres 22 are used for driving the embolism processing mechanism 2; the invention utilizes the change of blood osmotic pressure during thrombus formation to ensure that the liquid flowing into the cavity plays a role in changing the driving force of the microsphere 22; when the osmotic pressure outside the regulating cavity 20 increases, the flow rate and flow rate of the liquid passing through the semipermeable membrane 21 increases, so that the microspheres 22 are accelerated to move; as the osmotic pressure decreases, the flow rate and volume of fluid through the semipermeable membrane 21 decreases, and the amplitude and frequency of movement of the microspheres 22 decreases.
It should be noted that the semipermeable membrane 21 is selected because during the process of thrombosis, vascular endothelial cells are damaged, platelets and other blood components accumulate there to form a thrombus, these processes result in an increase in intravascular pressure, because the composition of thrombus and blood components itself has a higher osmotic pressure, and because of fibrin accumulation and platelet activation, a new local environment is formed inside the blood vessel, which environment has a much higher protein concentration than that of whole blood, and which local high osmotic pressure environment will help to maintain the steady state of thrombosis, and may also cause more cells and components to participate in the process of thrombosis, in which case, thrombus formation will change the local osmotic pressure inside the blood vessel and will cause the local high osmotic pressure environment formed there to help to maintain thrombus stability.
Thus, the semipermeable membrane 21 of the present invention may be selected from polymeric semipermeable membranes 21: the dialysis membrane is made of polyurethane, polyoxymethylene, polyamide, polyvinylidene fluoride and other materials, the specific material selection can be determined through the position and the blood flow rate, the polyurethane material is commonly used for the dialysis membrane of an artificial kidney, the polyoxymethylene material is used for the dialysis membrane of an artificial liver, and the polyvinylidene fluoride is used for high-flow-rate dialysis.
Nanofiltration membranes, which are semipermeable membranes 21 made of nanofiltration materials, are also used, which are capable of separating macromolecular substances such as proteins and cells, and are capable of protein purification, cell culture, etc.
The ceramic semipermeable membrane 21 can also be selected: the semipermeable membrane 21 made of a ceramic material has excellent filtration performance. The ceramic membrane has high stability, high temperature resistance, high pressure resistance, acid-base environment and the like, and can be used for unit operation and gas separation.
Also biological membranes: the semipermeable membrane 21 made of animal or plant tissue has good biocompatibility and high permeability, such as artificial blood vessel and artificial cornea.
The embolism processing mechanism 2 comprises a plurality of swinging rods 23, the swinging rods 23 are in semi-movable connection with the bracket body, the tail ends of the swinging rods extend into the adjusting cavity 20, and the other free ends face to the ring position of the detection bracket 1; one end of the swing rod 23 extending into the adjusting cavity 20 is contacted with the microsphere 22, the microsphere 22 can be driven by the liquid penetrating through the semipermeable membrane 21 to swing, after the microsphere 22 contacts the swing rod 23, the swing rod 23 is pushed to swing in the radial direction, so that the blood flow rate is enhanced, thrombus formation is avoided through acceleration of local blood flow, and a part which begins to form thrombus and is not completely plugged can be pushed through swing, so that further deterioration is avoided, and even the part is broken up and decomposed under a preferred condition.
Preferably, the detection bracket 1 is arranged at the position of the body or the valve of the ventricular assist device, and is close to the position of the ventricular assist device, so that blood clot can be effectively aimed at, and blood flow can be accelerated; and the annular structure is arranged on the body or the valve, so that the additional structure is avoided, and the blocking influence exceeding the existing ventricular assist device is avoided.
It should be noted that, the ventricular assist device is a mechanical device placed in the chest of a patient, and by connecting the left ventricle of the heart with the aorta, the heart is assisted to supply blood, so as to improve the heart failure symptoms of the patient, and the structure of the ventricular assist device in the body at least includes: infusion pipeline: the infusion pipeline connecting the pump body and the aorta is usually made of special flexible materials, so that the internal pressure change can be effectively resisted, and valves and devices, such as a regulator and a battery for controlling blood pressure, are arranged at the joint of the infusion pipeline; ventricular assist devices LVAD increase the risk of thrombosis due to long term use. The thrombus may form in the pump or tubing of the ventricular assist device or may occur in a blood vessel surrounding the ventricular assist device. Thrombosis may lead to the following conditions:
blocking pipes or pumps: thrombus may restrict the flow of ventricular assist devices, resulting in exacerbations of deficiency blood or heart failure.
Micro-embolism: small pieces of thrombus can fall off or break up, along the blood stream to organs or tissues, occluding arterioles or capillaries, resulting in organ damage or ischemic stroke.
Arterial embolism: thrombus may migrate to other parts of the body, such as cerebral vessels, kidneys, limbs, etc., causing ischemia, necrosis, dysfunction, etc. of the tissue.
The invention is preferably of a ring structure, can replace any section of the infusion pipeline, replaces the replaced section as a vascular access, is especially close to the connecting position of other parts such as a valve, is more likely to occur, has the outer wall flush with the outer wall of the pipeline, does not cause extra damage to the inner wall of the blood vessel, and has the semipermeable membrane 21 positioned on the inner side of the pipeline to realize the embolism prevention effect aiming at the inner part of the infusion pipeline.
Can also be arranged near the pump body: the pump body comprises a pump shaft, a magnetic bearing, a motor and the like, and is made of materials such as titanium metal, polymer and the like, so that the volume of the pump body is small. In a preferred embodiment of the present invention, the swing rod 23 extends out of the middle section of the rod body of the bracket body, at least one elastic section is provided, and the swing rod 23 can be folded along the direction of the blood flow through the elastic section, so that the formed blood clot which cannot be broken up or digested can pass through, the blood clot can be prevented from further expansion by slow release of the medicine, and the elastic section can also provide a rebound effect to restore the swing rod 23.
In a preferred embodiment, the elastic section is made of rubber.
Preferably, the end of the swing rod 23 extending into the adjusting cavity 20 is provided with a placing groove 231 for bearing the microsphere 22, the microsphere 22 is limited to move in the placing groove 231, the placing groove 231 preferably adopts a semi-cladding mode, namely, the effect of the liquid flow rate of the microsphere 22 passing through the semipermeable membrane 21 is guaranteed, the microsphere is ensured to be kept in the placing groove 231, the swing rod 23 is enabled to swing through the high-frequency impact of the placing groove 231, so that the swing rod 23 can improve the local blood flow rate, in some embodiments, the distance between the placing groove 231 and the inner wall of the adjusting cavity 20 is smaller than the radius of the microsphere 22 by matching and limiting the microsphere 22, preferably, the microsphere 22 corresponds to the swing rod 23 one by one, and the swing rod 23 can be distributed at equal intervals in the radial direction of the annular structure.
Preferably, the microsphere 22 is made of silica gel or rubber, so that a certain rebound resilience can be provided, and the most important function is to utilize self deformation to perform force unloading buffering, so that collision and vibration between the hard microsphere 22 and the hard swing rod 23 are avoided, and the service life of the device is reduced or the tightness is influenced.
Further, the interior of the microsphere 22 is hollow for weight reduction, and in other embodiments, the surface of the microsphere 22 is provided with holes therethrough to further enhance the elastic buffer capability.
Preferably, the semipermeable membrane 21 is fixedly connected with the support body, the semipermeable membrane 21 is obliquely arranged, and the oblique extending direction and the blood flow direction are acute angles, so that impurities or blood clots can be prevented from accumulating at the position of the semipermeable membrane 21, and the osmotic pressure difference can be directly and accurately fed back to the inside of the regulating cavity 20 and the action of the microspheres 22.
In addition, the semipermeable membrane 21 is also provided on the side of the blood flowing to the posterior position, and the inclination angle thereof is parallel to the semipermeable membrane 21 of the desired anterior channel, so that the blood reflux permeation at the posterior position can be reduced, and the impact of the opposite impact can be reduced.
In an embodiment, two protruding blocks 232 are disposed on the surface of the swing rod 23 and are respectively located at two sides of the inner wall of the bracket body, and are used for axially limiting the swing rod 23, meanwhile, radial shaking of the swing rod 23 is guaranteed, the swing rod 23 is limited through the arrangement of the protruding blocks 232 at two sides, and further, a sealing structure, such as a rubber sheet, is disposed between the protruding blocks 232 and the bracket body.
It should be noted that, the present invention can also adopt other hole shaft connection structures, and only needs to cover the sealing glue surface on the outer side, such as a pin shaft connection structure, a taper connection structure, etc.
In a preferred embodiment, the surface of the swing rod 23 is provided with spiral convex lines, and the surface structure is used for enabling the blood clot to be better decomposed and broken up when the blood clot is collided.
In some embodiments, the swing rod 23 is internally provided with a slow-release drug, and the surface of the swing rod 23 is hollowed out to provide a drug release window.
The drug that can be granulated and then put into the swing rod 23 to be slowly released by collision includes: antiplatelet drugs such as aspirin and clopidogrel can reduce thrombosis and prevent occurrence and development of cardiovascular and cerebrovascular diseases by inhibiting aggregation and aggregation of platelets.
Anticoagulation medicine: such as heparin, warfarin, enoxaparin, low molecular heparin, etc., can inhibit blood coagulation, reduce thrombosis, and prevent arterial and venous thrombosis.
Fibrinolytic drugs such as urokinase, recombinant tissue type plasminogen activator (rt-PA) and the like can promote vascular endothelial cells to release the plasminogen activator and promote thrombolysis, thereby playing a role in thrombolysis.
Further, the diameter of the slow-release drug is smaller than the inner diameter of the swing rod 23, the slow-release drug can collide with the inner wall of the swing rod 23, so that the release of the slow-release drug is accelerated, and under the influence of high osmotic pressure in the process of thrombus formation or to be formed, the accelerated swing of the microsphere 22 can release the drug more quickly, so that the targeted control of the drug release amount is formed.
In summary, the annular detecting bracket 1 is arranged on the blood channel of the ventricular assist device, and the osmotic pressure change is converted into the change of the liquid flow rate and the internal pressure in the detecting bracket 1 through the influence of blood clot and thrombus formation and the arrangement of the semipermeable membrane 21, so that the microspheres 22 in the adjusting cavity body can perform targeted moving impact under different conditions to drive the swinging rod 23 to swing radially, on one hand, the swinging of the part of the swinging rod 23 extending out of the bracket body can be realized, the local blood flow rate can be accelerated, further thrombus formation can be avoided through accelerating the flow rate, on the other hand, the medicine in the swinging rod 23 can be diffused and released through swinging, and the release speed can be increased along with the swing amplitude and frequency, namely, more medicine release can be performed in the face of more serious blood clot conditions.
In addition, the microsphere 22 in the invention is preferably a hollow structure, not only can receive the thrust from the liquid through the surface of the microsphere, but also the liquid passing through the semipermeable membrane 21 flows from a high osmotic pressure position formed by thrombus to an inner low osmotic pressure position, and the osmotic pressure difference is larger, so that the osmotic speed is larger, the microsphere 22 is prepared by adopting an elastic material after collision so as to avoid vibration, and the buffer capacity of the microsphere 22 is increased by the arrangement of the hollow structure, so that excessive vibration is avoided, and the weight reduction effect can be achieved, and the influence of external thrust is more direct and effective, so that the sensitivity to the change of the flow rate of the inner liquid is ensured.
In addition, one end of the swing rod 23 in the adjusting cavity 20 is provided with a limiting structure, and the microspheres 22 can act on the swing rod 23 in a one-to-one correspondence manner through limiting the microspheres 22, so that the confliction of mutual collision is avoided, and the microspheres 22 can apply force to the swing rod 23 more effectively at high frequency in a limited space, so that the swing rod can swing efficiently; the upper segment structure of the swing rod 23 outside the adjusting cavity 20 is characterized in that a plurality of segments are connected through elastic materials, so that the swing rod 23 outside the adjusting cavity 20 can be bent, and the situation that blood clots which cannot be decomposed and scattered are blocked at the position of the swing rod 23 and severe embolism is caused is avoided.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art in a specific case.
The above-described preferred embodiments according to the present invention are intended to suggest that, from the above description, various changes and modifications can be made by the person skilled in the art without departing from the scope of the technical idea of the present invention. The technical scope of the present invention is not limited to the description, but must be determined according to the scope of claims.
Claims (10)
1. A ventricular assist device for cardiac surgery, comprising: detect the support and set up embolic processing mechanism on the detection support, its characterized in that:
the detection support is of an annular structure and comprises a support body and an adjusting cavity arranged in the support body, a semi-permeable membrane is arranged on the end face of the support body, and the adjusting cavity is communicated with an external space through the semi-permeable membrane;
microspheres are arranged in the adjusting cavity and can move in the adjusting cavity, and the microspheres are used for driving the embolism treatment mechanism;
the embolism treatment mechanism comprises a plurality of swing rods, the swing rods are movably connected with the bracket body, one ends of the swing rods extend into the adjusting cavity, and the other free ends face to the inner ring position of the detection bracket;
one end of the swing rod extending into the adjusting cavity is contacted with the microsphere, and the microsphere can float and move under the drive of liquid penetrating through the semipermeable membrane;
when the osmotic pressure outside the regulating cavity is increased, the flow rate and flow rate of the liquid passing through the semipermeable membrane are increased, so that the microspheres are accelerated to move.
2. A cardiac ventricular assist device as claimed in claim 1, wherein: the detection support is arranged at the body or the valve position of the ventricular assist device.
3. A cardiac ventricular assist device as claimed in claim 1, wherein: and one end of the swing rod, which extends into the adjusting cavity, is provided with a placing groove for bearing the microspheres, the microspheres are limited to limited movement in the placing groove, and the microspheres are in one-to-one correspondence with the swing rod.
4. A cardiac ventricular assist device as claimed in claim 1, wherein: the microsphere is made of silica gel or rubber.
5. A cardiac ventricular assist device as claimed in claim 1, wherein: holes are formed in the surfaces and the interiors of the microspheres in a penetrating manner and are used for reducing weight and enhancing elastic buffer space.
6. A cardiac ventricular assist device as claimed in claim 1, wherein: the semipermeable membrane is fixedly connected with the support body, the semipermeable membrane is obliquely arranged, and the oblique extension direction and the blood flow direction are acute angles.
7. A cardiac ventricular assist device as claimed in claim 1, wherein: the surface of the swing rod is provided with two convex blocks which are respectively positioned at two sides of the inner wall of the bracket body and used for axially limiting the swing rod and simultaneously guaranteeing radial shaking of the swing rod.
8. A cardiac ventricular assist device as claimed in claim 1, wherein: the surface of the swing rod is provided with spiral convex lines.
9. A cardiac ventricular assist device as claimed in claim 1, wherein: the swing rod is internally provided with a slow-release drug, and the surface of the swing rod is hollowed out and is used for providing a drug release window.
10. A cardiac ventricular assist device as recited in claim 9 wherein: the diameter of the slow-release medicine is smaller than the inner diameter of the swing rod, and the slow-release medicine can collide with the inner wall of the swing rod.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310790274.4A CN116672597A (en) | 2023-06-30 | 2023-06-30 | Ventricular assist device for cardiac surgery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310790274.4A CN116672597A (en) | 2023-06-30 | 2023-06-30 | Ventricular assist device for cardiac surgery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116672597A true CN116672597A (en) | 2023-09-01 |
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ID=87780962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310790274.4A Withdrawn CN116672597A (en) | 2023-06-30 | 2023-06-30 | Ventricular assist device for cardiac surgery |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116672597A (en) |
-
2023
- 2023-06-30 CN CN202310790274.4A patent/CN116672597A/en not_active Withdrawn
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