CN116672570A - Low-pressure injection thrombolysis microcatheter - Google Patents
Low-pressure injection thrombolysis microcatheter Download PDFInfo
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- CN116672570A CN116672570A CN202310967917.8A CN202310967917A CN116672570A CN 116672570 A CN116672570 A CN 116672570A CN 202310967917 A CN202310967917 A CN 202310967917A CN 116672570 A CN116672570 A CN 116672570A
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- tube body
- guide wire
- structural layer
- perforation
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
- A61M25/0075—Valve means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
- A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/09—Guide wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
- A61M25/0074—Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
- A61M2025/0079—Separate user-activated means, e.g. guidewires, guide tubes, balloon catheters or sheaths, for sealing off an orifice, e.g. a lumen or side holes, of a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/12—Blood circulatory system
Abstract
The application relates to the technical field of medical appliances and discloses a low-pressure injection thrombolysis micro-catheter which comprises a catheter body, a guide wire and a valve body, wherein the catheter body is suitable for being introduced into a blood vessel, the catheter body is provided with a first channel and a perforation, the first channel is suitable for storing medicines, the perforation is positioned on the peripheral wall of one end of the catheter body, the perforation is communicated with the first channel, when the pressure value in the first channel is smaller than or equal to a preset pressure value, the perforation can be opened, so that medicines in the first channel can flow out through the perforation, the guide wire can be introduced into the first channel, and one end of the guide wire can pass through the end of the catheter body to provide a guiding effect for the movement of the catheter body. The valve body is arranged at the end part of the pipe body, one end of the guide wire can penetrate through the valve body, the guide wire can be pulled out from the pipe body, and when the guide wire is separated from the end part of the pipe body, the valve body can be closed to prevent the medicine in the first channel from flowing out. The low-pressure injection thrombolysis microcatheter provided by the embodiment of the application not only can realize end closure of the tube body, but also can expand the treatment range.
Description
Technical Field
The application relates to the technical field of medical instruments, in particular to a low-pressure injection thrombolysis microcatheter.
Background
Acute ischemic cerebral apoplexy is a common clinical disease and frequently-occurring disease of neurology, is one of three main diseases which endanger human life and health and cause human death in the world, and has the characteristics of high morbidity, high recurrence rate, high mortality rate and high disability rate. Before a stroke reverts to cerebral perfusion, 190 ten thousand neurons and 140 hundred million nerve synapses die every minute, so must be said to be a minute and a second. Reperfusion therapy is currently a well-accepted worldwide effective means of reducing patient disability and mortality for acute ischemic stroke. While intravenous thrombolysis is currently the most important measure for restoring cerebral blood flow, the worldwide therapeutic guidelines state thrombolysis as the first recommended means in the treatment of acute ischemic stroke patients.
In the related art, the solutions of thrombolytic catheters are mainly double-cavity thrombolytic catheters, and the inner cavity of the catheter is inserted with a plugging guide wire/balloon type thrombolytic catheter, so that the size of the catheter is usually larger and can not reach the distal artery and vein of a blood vessel due to the limitation of the plugging mode of the solutions, the treatment effect and the operation difficulty are greatly limited, and the dosage is relatively larger.
Disclosure of Invention
The present application aims to solve at least one of the technical problems in the related art to some extent. Therefore, the embodiment of the application provides the low-pressure injection thrombolysis microcatheter which not only can realize end closure of the tube body, but also can enlarge the treatment range.
The low-pressure injection thrombolytic microcatheter of the embodiment of the application comprises:
the tube body is suitable for being introduced into a blood vessel, the tube body is provided with a first channel and a perforation, the first channel extends along the extending direction of the tube body, the first channel is internally suitable for storing medicines, the perforation is positioned on the peripheral wall of one end of the tube body, the perforation is communicated with the first channel, and when the pressure value in the first channel is smaller than or equal to a preset pressure value, the perforation can be opened, so that the medicines in the first channel can flow out through the perforation;
a guide wire, which can be led into the first channel, one end of the guide wire can pass through the end part of the pipe body to provide a guiding function for the movement of the pipe body;
the valve body is arranged at the end part of the pipe body, one end of the guide wire can penetrate through the valve body, the guide wire can be pulled out of the pipe body, and when the guide wire is separated from the end part of the pipe body, the valve body can be closed to prevent the medicine in the first channel from flowing out.
Further, the valve body includes a first portion and a second portion having a gap therebetween, one end of the guide wire being insertable through the gap, the gap being closed when the guide wire is withdrawn from the tube.
Further, the low-pressure injection thrombolysis microcatheter further comprises a developing part, wherein the developing part is arranged at one end of the tube body, the developing part is arranged around the outer wall surface of the tube body for a circle, the developing part and the perforation are arranged at intervals in the extending direction of the tube body, and the developing part is used for displaying the outflow position of the medicine.
Further, the developing parts are at least two, the developing parts are arranged at one end of the tube body, the developing parts are arranged at intervals along the extending direction of the tube body, and the perforation is positioned between the developing parts.
Further, the perforations are plural, the plural perforations are divided into plural groups, the plural groups of the perforations are arranged between at least two of the developing members at intervals along the extending direction of the tube body, each group of the perforations includes plural perforations, and plural perforations in each group of the perforations are arranged at intervals around the circumference of the outer wall surface of the tube body.
Further, the low-pressure injection thrombolysis micro-catheter also comprises a catheter seat, wherein the catheter seat is arranged at the other end of the catheter body, the catheter seat is suitable for being provided with a device for storing medicines, the catheter seat is provided with a second channel, the second channel is communicated with the first channel, and the device for storing medicines is communicated into the first channel through the second channel.
Further, the low-pressure injection thrombolysis micro-catheter further comprises a stress release device, wherein the stress release device is connected with the catheter seat and the other end of the catheter body, the stress release device is provided with a third channel, the third channel is communicated with the first channel and the second channel, and the stress release device is used for reinforcing the structural strength of the catheter seat and the catheter body.
Further, the outer circumference profile of the cross section of the pipe body is circular, the outer diameter of the other end of the pipe body is larger than the outer diameter of one end of the pipe body, and the outer diameter from the outer diameter of the other end of the pipe body to the outer diameter of one end of the pipe body gradually decreases along the extending direction of the pipe body.
Further, the tube body comprises a first structural layer, a second structural layer and a third structural layer which are sequentially arranged from inside to outside, and the developing piece is positioned between the second structural layer and the third structural layer.
Further, the first structural layer has a lubricating effect, so that the guide wire can conveniently pass through the channel, the second structural layer is arranged around the outer wall surface of the first structural layer, the second structural layer has a reinforcing structure effect, and the third structural layer is arranged around the outer wall surface of the second structural layer, so that the second structural layer is prevented from damaging the inner wall of a blood vessel.
The beneficial effects of the application are as follows:
according to the low-pressure injection thrombolysis microcatheter, one end of the guide wire penetrates through the valve body at the end part of the tube body to guide the tube body to move in a blood vessel, when the tube body moves to a designated position, the guide wire is guided to draw out the first channel, the valve body is in a closed state to prevent medicine in the first channel from flowing out and blood in the blood vessel from flowing into the first channel, and the medicine in the first channel flows out through the perforation.
Drawings
Fig. 1 is a schematic view of a low pressure injection thrombolytic microcatheter according to an embodiment of the application.
Fig. 2 is a partial schematic view of a low pressure injection thrombolytic microcatheter according to an embodiment of the application.
Fig. 3 is a schematic view of a guide wire of a low pressure injection thrombolytic microcatheter in a first channel according to an embodiment of the application.
Fig. 4 is a schematic closure diagram of a valve body of a low pressure injection thrombolytic microcatheter according to an embodiment of the application.
Fig. 5 is an open schematic view of a valve body of a low pressure injection thrombolytic microcatheter according to an embodiment of the application.
Fig. 6 is a schematic view of a low pressure injection thrombolytic microcatheter in a blood vessel according to an embodiment of the application.
Reference numerals: 1. a tube body; 11. a first channel; 12. perforating; 13. a first structural layer; 14. a second structural layer; 15. a third structural layer; 2. a guide wire; 3. a valve body; 31. a first portion; 32. a second portion; 33. a slit; 4. a developing member; 5. a catheter holder; 6. a stress relief means; 7. a blood vessel; 71. thrombus.
Detailed Description
Reference will now be made in detail to embodiments of the present application, examples of which are illustrated in the accompanying drawings. The embodiments described below by referring to the drawings are illustrative and intended to explain the present application and should not be construed as limiting the application.
As shown in fig. 1 to 6, the low-pressure injection thrombolysis microcatheter according to the embodiment of the present application comprises a tube body 1, a guide wire 2 and a valve body 3. The tube body 1 is suitable for being introduced into the blood vessel 7, the tube body 1 is provided with a first channel 11 and a perforation 12, the first channel 11 extends along the extending direction of the tube body 1, the first channel 11 is suitable for storing medicines, the perforation 12 is positioned on the peripheral wall of one end (the right end of the tube body 1 shown in fig. 1) of the tube body 1, the perforation 12 is communicated with the first channel 11, and when the pressure value in the first channel 11 is less than or equal to a preset pressure value, the perforation 12 can be opened, so that medicines in the first channel 11 can flow out through the perforation 12.
Specifically, the perforation 12 is formed by laser perforation, and the diameter of the perforation 12 is 20 nm-100 nm, when the pressure value in the first channel 11 is less than or equal to the preset pressure value, the medicine in the first channel 11 flows out in a drip through the perforation 12.
In some embodiments, the low-pressure injection thrombolytic microcatheter according to the present application further comprises a constant pressure device (not shown) in communication with the first channel 11 to continuously introduce atmospheric pressure into the first channel 11 through the constant pressure device such that the rate of introducing atmospheric pressure into the first channel 11 through the constant pressure device is substantially greater than the rate of escape of the atmospheric pressure in the first channel 11 from the perforation 12, thereby maintaining the atmospheric pressure in the first channel 11 at a predetermined pressure value or less. The preset pressure value is a value of 3 standard atmospheres, which is noted as 3atm. When the pressure preset value in the first passage 11 is 3atm or less, the medicine in the first passage 11 can flow out through the perforation 12 to treat the thrombus 71 in the blood vessel 7.
In some embodiments, the perforations 12 and cross-section are circular, with the perforations 12 having a diameter of 40-200um.
The guide wire 2 may be passed into the first channel 11 and one end of the guide wire 2 (the right end of the guide wire 2 as shown in fig. 3) may be passed through the end of the tube 1 to provide a guiding effect for the movement of the tube 1. The valve body 3 is arranged at the end part of the pipe body 1, one end of the guide wire 2 can penetrate through the valve body 3, the guide wire 2 can be pulled out from the pipe body 1, and when the guide wire 2 is separated from the end part of the pipe body 1, the valve body 3 can be closed to prevent the medicine in the first channel 11 from flowing out. Specifically, the valve body 3 is provided at an end of the right end of the pipe body 1, and the right end of the guide wire 2 may pass through the valve body 3 to guide the pipe body 1.
Specifically, the valve body 3 is provided at the end of the tube body 1, and also allows the overall size of the tube body 1 to be reduced so that the tube body 1 reaches further to the blood vessel 7 under the guidance of the guide wire 2.
According to the low-pressure injection thrombolysis micro-catheter disclosed by the embodiment of the application, the right end of the guide wire 2 passes through the valve body 3at the right end part of the catheter body 1 so as to guide the catheter body 1 to move in the blood vessel 7, when the catheter body 1 moves to a designated position, the guide wire 2 is pulled out of the first channel 11, and the valve body 3 is in a closed state so as to prevent the medicine in the first channel 11 from flowing out and the blood in the blood vessel 7 from flowing into the first channel 11, so that the medicine in the first channel 11 flows out through the perforation 12.
Therefore, the low-pressure injection thrombolysis microcatheter not only realizes the function of closing the end part of the tube body 1, but also can reach the far position of the blood vessel 7 under the guidance of the guide wire 2, thereby expanding the treatment range and being simple to operate during use.
In some embodiments, the valve body 3 comprises a first portion 31 and a second portion 32, with a gap 33 between the first portion 31 and the second portion 32, through which gap 33 one end of the guide wire 2 can pass, the gap 33 closing when the guide wire 2 is withdrawn from the tube 1.
Specifically, as shown in fig. 4 and 5, the cross section of the valve body 3 is circular. The slit 33 is located at an intermediate position of the valve body 3, and the slit 33 extends in a first direction (as shown in fig. 4). The slit 33 divides the valve body 3 into a first portion 31 and a second portion 32 that are sequentially arranged in the up-down direction, and the first portion 31 is located above the second portion 32.
Specifically, the valve body 3 is made of silica gel, so that when the guide wire 2 is introduced into the first channel 11, the right end of the guide wire 2 can pass through the slit 33 to expand the first portion 31 and the second portion 32, so that at least part of the first portion 31 and at least part of the second portion 32 move away from each other, and the slit 33 is opened. Since the silicone itself has elasticity, the sides of the first portion 31 and the second portion 32 adjacent to the guide wire 2 are in close contact with the outer peripheral surface of the guide wire 2, so that the medicine in the first channel 11 is not easy to flow out from the slit 33. When the guide wire 2 is pulled out of the first channel 11, the right end of the guide wire 2 is pulled out of the gap 33, and at least part of the first portion 31 and at least part of the second portion 32 move towards each other due to the elasticity of the silica gel, so that the gap 33 is restored to a closed state, and the medicine in the first channel 11 is not easy to enter the blood vessel 7 through the gap 33. Therefore, the valve body 3 is simple in structure, easy to manufacture, cost-saving and simple to use.
In some embodiments, the low-pressure injection thrombolytic microcatheter further comprises a developing member 4, wherein the developing member 4 is arranged at one end of the tube body 1, the developing member 4 is arranged around the outer wall surface of the tube body 1, the developing member 4 and the perforation 12 are arranged at intervals in the extending direction of the tube body 1, and the developing member 4 is used for displaying the outflow position of the medicine.
Specifically, as shown in fig. 1, the developing member 4 is provided at the right end of the tube body 1 and provided around the outer wall surface of the tube body 1 by one turn. The developing member 4 is a developing mark which does not project light, and the developing member 4 facilitates a doctor to accurately push the tube body 1 to a designated position of the blood vessel 7 under X-rays. Further, the perforations 12 and the developing member 4 are arranged at intervals on the outer wall surface of the right end of the tube body 1 so that the developing member 4 can also show the position where the medicine flows out. Therefore, the accuracy of the low-pressure injection thrombolytic microcatheter is improved.
In some embodiments, there are at least two developing members 4, at least two developing members 4 are provided at one end of the tube body 1, and at least two developing members 4 are arranged at intervals along the extending direction of the tube body 1 with the perforation 12 being located between at least two developing members 4.
Specifically, as shown in fig. 1 to 3, there are two developing members 4, two developing members 4 are provided on the outer wall surface of the right end of the tube body 1, and the two developing members 4 are arranged at intervals in the left-right direction. The perforation 12 is located between the two developing members 4. The catheter body 1 is clearly distinguished under rays, so that a doctor can observe the position of the right end of the catheter body 1 in the operation process, the aim of accurately judging the position of a catheter by the doctor is effectively achieved, and the accurate treatment of thrombus 71 by the medicine flowing out of the perforation 12 is facilitated.
In some embodiments, the perforations 12 are plural, the plural perforations 12 are divided into plural groups, and the plural groups of perforations 12 are arranged at intervals between at least two developing members 4 along the extending direction of the tube body 1. Each group of perforations 12 includes a plurality of perforations 12, the plurality of perforations 12 in each group of perforations 12 being circumferentially spaced around the outer wall surface of the tube body 1.
Specifically, as shown in fig. 2 and 3, the perforations 12 are plural, so that the amount of the drug flowing from the first passage 11 into the blood vessel 7 through the perforations 12 is increased, and the therapeutic effect of the drug on the thrombus 71 can be further improved.
In some embodiments, the low pressure injection thrombolytic microcatheter further comprises a catheter hub 5, the catheter hub 5 being disposed at the other end of the catheter body 1, the catheter hub 5 being adapted to receive a drug-containing device, the catheter hub 5 having a second channel (not shown) in communication with the first channel 11, the drug-containing device being configured to pass the drug through the second channel into the first channel 11.
In particular, the catheter hub 5 is provided to facilitate connection to a device for storing a medicament. The medicine is injected into the second channel through the instrument for storing the medicine, and in the process, the medicine can flow into the first channel 11 from the second channel, and air in the second channel and the first channel 11 can be exhausted, so that the purity of the medicine in the first channel 11 is improved.
In particular, the device for storing the medicament is.
In some embodiments, the low pressure injection thrombolytic microcatheter further comprises a stress relief device 6, the stress relief device 6 connecting the catheter hub 5 and the other end of the catheter body 1, the stress relief device 6 having a third channel (not shown) in communication with the first channel 11 and the second channel, the stress relief device 6 serving to strengthen the structural strength of the catheter hub 5 and the catheter body 1.
Specifically, as shown in fig. 1, the stress releasing device 6 is connected to the left ends of the catheter seat 5 and the catheter body 1, so that the stress releasing device 6 can effectively avoid bending or breaking of the catheter seat 5 and the catheter body 1 under the action of external force, and the structural strength of the low-pressure injection thrombolytic micro catheter in the embodiment of the application is improved.
In some embodiments, the outer circumference of the cross section of the tube body 1 is circular, and the outer diameter of the other end of the tube body 1 (the left end of the tube body 1 as shown in fig. 1) is larger than the outer diameter of one end of the tube body 1, and the outer diameter of one end of the tube body 1 gradually decreases along the extending direction of the tube body 1. Specifically, the outer diameter of the left end of the tube body 1 is larger than the outer diameter of the right end of the tube body 1, and the outer diameter of the right end of the tube body 1 gradually decreases in the rightward direction.
Specifically, the tube body 1 has multiple specifications, and the diameter range of the multiple tube bodies 1 is 0.5mm-2mm, so that the tube bodies 1 with different specifications can be suitable for blood vessels 7 with different diameters, and the applicability of the low-pressure injection thrombolytic microcatheter according to the embodiment of the application is improved.
In some embodiments, the tube body 1 includes a first structural layer 13, a second structural layer 14, and a third structural layer 15 arranged in that order from the inside to the outside, with the development member 4 being located between the second structural layer 14 and the third structural layer 15. Specifically, as shown in fig. 2 and 3, the first structural layer 13, the second structural layer 14, and the third structural layer 15 are arranged in order from the inner wall surface of the first passage 11 to the outer wall surface of the first passage 11.
Specifically, the first structural layer 13 is composed of a PTFE material and a HDPE material, so that the wall surface of the first structural layer 13 has a smooth property, and the lubricity of the first structural layer 13 is improved to facilitate the passage of the guide wire 2 through the first passage 11.
The second structural layer 14 is disposed around the outer wall surface of the first structural layer 13, and the second structural layer 14 is formed of braided wires having shape memory super elasticity such as nitinol, 304 stainless steel, etc., and PPI is preferably 60-150. The second structural layer 14 has the function of a reinforcing structure.
The third structural layer 15 is arranged around the outer wall surface of the second structural layer 14 to avoid that the second structural layer 14 damages the inner wall of the blood vessel 7. Specifically, the third structural layer 15 is made of an outer layer material such as polyamide, polyether amide, polyurethane, and the like.
In some embodiments, a developing material such as barium sulfate or bismuth sulfate is also added to the third structural layer 15 to allow the physician to see the morphology of the entire tube 1 under X-rays.
In some embodiments, the third structural layer 15 is attached to the outer wall surface of the second structural layer 14 using a thermal compounding process.
In some embodiments, the third structural layer 15 includes a plurality of third sub-structural layers (not shown) that are sequentially arranged along the extension direction of the second structural layer 14, and adjacent third sub-structural layers are connected with each other by a thermal butt joint direction. Therefore, the third structure layer 15 has simple structure, easy manufacture, mass production and simplified process.
In some embodiments, the outer wall surface of the third structural layer 15 is further provided with a coating (not shown) which is polyvinylpyrrolidone, so that the lubricity of the tube body 1 in the blood vessel 7 can be significantly improved, and the tube body 1 can be smoother when moving in the blood vessel 7.
In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.
Furthermore, the terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In the description of the present application, the meaning of "plurality" means at least two, for example, two, three, etc., unless specifically defined otherwise.
In the present application, unless explicitly specified and limited otherwise, the terms "mounted," "connected," "secured," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally formed; may be mechanically connected, may be electrically connected or may be in communication with each other; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art according to the specific circumstances.
In the present application, unless expressly stated or limited otherwise, a first feature "up" or "down" a second feature may be the first and second features in direct contact, or the first and second features in indirect contact via an intervening medium. Moreover, a first feature being "above," "over" and "on" a second feature may be a first feature being directly above or obliquely above the second feature, or simply indicating that the first feature is level higher than the second feature. The first feature being "under", "below" and "beneath" the second feature may be the first feature being directly under or obliquely below the second feature, or merely indicating that the first feature level is less than or equal to the second feature.
For purposes of this disclosure, the terms "one embodiment," "some embodiments," "example," "a particular example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
While the above embodiments have been shown and described, it should be understood that the above embodiments are illustrative and not to be construed as limiting the application, and that variations, modifications, alternatives, and variations of the above embodiments may be made by those of ordinary skill in the art without departing from the scope of the application.
Claims (10)
1. A low pressure injection thrombolytic microcatheter comprising:
a tube body (1), wherein the tube body (1) is suitable for being introduced into a blood vessel (7), the tube body (1) is provided with a first channel (11) and a perforation (12), the first channel (11) extends along the extending direction of the tube body (1), medicines are suitable for being stored in the first channel (11), the perforation (12) is positioned on the peripheral wall of one end of the tube body (1), the perforation (12) is communicated with the first channel (11), and when the pressure value in the first channel (11) is smaller than or equal to a preset pressure value, the perforation (12) can be opened, so that the medicines in the first channel (11) can flow out through the perforation (12);
-a guide wire (2), which guide wire (2) can be passed into the first channel (11), one end of the guide wire (2) being passed through the end of the tube body (1) to provide a guiding action for the movement of the tube body (1);
valve body (3), valve body (3) are established the tip of body (1), the one end of guide wire (2) can pass valve body (3), guide wire (2) can follow body (1) are taken out, just when guide wire (2) break away from the tip of body (1), valve body (3) can be closed in order to prevent in first passageway (11) the medicine flows out.
2. The low pressure injection thrombolytic microcatheter of claim 1, wherein the valve body (3) comprises a first portion (31) and a second portion (32), wherein a gap (33) is provided between the first portion (31) and the second portion (32), wherein one end of the guide wire (2) is passed through the gap (33), and wherein the gap (33) is closed when the guide wire (2) is withdrawn from the tube body (1).
3. The low-pressure injection thrombolytic microcatheter according to claim 1, further comprising a developing member (4), wherein the developing member (4) is provided at one end of the tube body (1), and the developing member (4) is provided around an outer wall surface of the tube body (1) for one week, the developing member (4) and the perforation (12) are arranged at intervals in an extending direction of the tube body (1), and the developing member (4) is used for displaying a position where the medicine flows out.
4. A low pressure injection thrombolytic microcatheter according to claim 3, wherein the number of developing members (4) is at least two, at least two developing members (4) are provided at one end of the tube body (1), and at least two developing members (4) are arranged at intervals along the extending direction of the tube body (1), and the perforation (12) is located between at least two developing members (4).
5. The low-pressure injection thrombolytic microcatheter according to claim 4, wherein the perforations (12) are plural, the perforations (12) are divided into plural groups, the plural groups of the perforations (12) are arranged between at least two of the developing members (4) at intervals along the extending direction of the tube body (1), each group of the perforations (12) includes plural perforations (12), and plural perforations (12) in each group of the perforations (12) are arranged at intervals around the circumference of the outer wall surface of the tube body (1).
6. The low pressure injection thrombolytic microcatheter of claim 1 further comprising a catheter hub (5), said catheter hub (5) being provided at the other end of said tube (1), said catheter hub (5) being adapted for receiving a drug-storing device, said catheter hub (5) having a second channel, said second channel being in communication with said first channel (11), said drug-storing device being adapted for introducing said drug into said first channel (11) through said second channel.
7. The low pressure injection thrombolytic microcatheter of claim 6 further comprising a stress relief device (6), said stress relief device (6) connecting said catheter hub (5) and the other end of said tube (1), said stress relief device (6) having a third channel in communication with said first channel (11) and said second channel, said stress relief device (6) for reinforcing the structural strength of said catheter hub (5) and said tube (1).
8. The low-pressure injection thrombolytic microcatheter according to claim 1, wherein the outer peripheral contour of the cross section of the tube body (1) is circular, the outer diameter of the other end of the tube body (1) is larger than the outer diameter of one end of the tube body (1), and the outer diameter from the outer diameter of the other end of the tube body (1) to the outer diameter of one end of the tube body (1) gradually decreases along the extending direction of the tube body (1).
9. A low pressure injection thrombolytic microcatheter according to claim 3, characterized in that the tube body (1) comprises a first structural layer (13), a second structural layer (14) and a third structural layer (15) arranged in sequence from inside to outside, the developing member (4) being located between the second structural layer (14) and the third structural layer (15).
10. The low pressure injection thrombolytic microcatheter of claim 9, wherein the first structural layer (13) has a lubrication effect to facilitate the passage of the guide wire (2) through the channel, the second structural layer (14) is arranged around the outer wall surface of the first structural layer (13), the second structural layer (14) has a reinforcement structure effect, and the third structural layer (15) is arranged around the outer wall surface of the second structural layer (14) to avoid the second structural layer (14) damaging the inner wall of the blood vessel (7).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310967917.8A CN116672570A (en) | 2023-08-03 | 2023-08-03 | Low-pressure injection thrombolysis microcatheter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310967917.8A CN116672570A (en) | 2023-08-03 | 2023-08-03 | Low-pressure injection thrombolysis microcatheter |
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| Publication Number | Publication Date |
|---|---|
| CN116672570A true CN116672570A (en) | 2023-09-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310967917.8A Pending CN116672570A (en) | 2023-08-03 | 2023-08-03 | Low-pressure injection thrombolysis microcatheter |
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| CN (1) | CN116672570A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117426833A (en) * | 2023-12-20 | 2024-01-23 | 北京华脉泰科医疗器械股份有限公司 | Thrombolysis catheter inner core and thrombolysis catheter |
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| CN107073246A (en) * | 2014-09-30 | 2017-08-18 | 百乐仕医疗器械有限公司 | Foley's tube |
| CN219110581U (en) * | 2022-12-12 | 2023-06-02 | 微创神通医疗科技（上海）有限公司 | Drug delivery device |
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| US20020077594A1 (en) * | 2000-12-19 | 2002-06-20 | Scimed Life Systems, Inc. | Drug delivery catheter having a highly compliant balloon with infusion holes |
| US20050059931A1 (en) * | 2003-09-16 | 2005-03-17 | Venomatrix | Methods and apparatus for localized and semi-localized drug delivery |
| CN105007973A (en) * | 2013-01-15 | 2015-10-28 | A.V.医疗科技有限公司 | Infusion catheter with guidewire valving |
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| CN117426833B (en) * | 2023-12-20 | 2024-03-08 | 北京华脉泰科医疗器械股份有限公司 | Thrombolysis catheter inner core and thrombolysis catheter |
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