CN116672488A - Bismuth-containing burn dressing and preparation method thereof - Google Patents
Bismuth-containing burn dressing and preparation method thereof Download PDFInfo
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- CN116672488A CN116672488A CN202310878367.2A CN202310878367A CN116672488A CN 116672488 A CN116672488 A CN 116672488A CN 202310878367 A CN202310878367 A CN 202310878367A CN 116672488 A CN116672488 A CN 116672488A
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides a bismuth-containing burn dressing and a preparation method thereof, and relates to the technical field of medical dressings, comprising a back adhesive layer, an antibacterial matrix layer and a release layer which are sequentially laminated; wherein the antibacterial matrix layer comprises a bismuth-containing polyurethane sponge layer; the raw materials of the bismuth-containing polyurethane sponge layer comprise bismuth-containing compounds; the bismuth-containing compound is introduced into the bismuth-containing polyurethane sponge layer by a first-in-last foaming mode. The bismuth-containing burn dressing provided by the invention is introduced with the bismuth-containing polyurethane sponge layer prepared by the first adding-then foaming mode, so that the bismuth-containing compound is embedded into the sponge matrix, thereby avoiding a great amount of bismuth-containing compound from falling off and gathering at a wound surface in a short time while guaranteeing the antibacterial effect of the dressing, improving the safety, prolonging the release time of the bismuth-containing compound and being beneficial to realizing long-acting antibacterial effect.
Description
Technical Field
The invention relates to the technical field of medical dressing, in particular to a bismuth-containing burn dressing and a preparation method thereof.
Background
Burn is generally a tissue injury caused by heat, electric current, chemicals, laser, radiation, etc., and is a common accidental injury in life and production. If the wound on the burn position is improperly treated, the burn position is not only life-threatening, but also is easy to leave scars and disabilities.
Worldwide, burns are a significant cause of rising mortality and morbidity. With the development and improvement of the medical science and technology level, and at the same time, in order to reduce the treatment cost, many dressing materials for treating or caring burn wounds are gradually developed and widely used, wherein calcium alginate dressing materials, polyvinyl acetal medical sponge, polyurethane medical sponge and the like having high absorptivity are commonly used as post-burn care and protection dressing materials, and by means of these dressing materials, seepage can be effectively absorbed, impregnation of wounds can be prevented, and comfortable and moist healing environment can be provided for the wounds.
With the diversification of the needs, antibacterial burn wound dressings have attracted increasing attention, and particularly, bismuth tribromophenol Vaseline dressings have been widely used for decades for the treatment of II degree burns, as well as for the care after skin grafting. The low cost, ease of use and low infection rate of bismuth tribromophenol Vaseline dressing have been widely studied to demonstrate that it is effective in inhibiting bacterial proliferation and accelerating wound healing. The existing tribromophenol bismuth Vaseline dressing is obtained by coating Vaseline containing tribromophenol bismuth on a base material such as non-woven fabric, and has good antibacterial and therapeutic effects, but bismuth compounds are easy to burst, largely fall off and gather in skin tissues to further enter blood, accumulate in human tissues or organs, are difficult to metabolize and excrete, and easily generate great risks.
Disclosure of Invention
The invention aims to solve the technical problems that: in order to solve the problem that bismuth compounds of the tribromophenol bismuth vaseline dressing in the prior art are easy to burst, the invention provides the bismuth-containing burn dressing, and the bismuth compounds are firmly embedded into a polyurethane sponge matrix by introducing the polyurethane sponge containing the bismuth compounds, so that stable and long-acting antibacterial effect of the dressing is realized while burst of the bismuth compounds is avoided, and the problem that the bismuth compounds of the tribromophenol bismuth vaseline dressing in the prior art are easy to burst is solved.
The technical scheme adopted for solving the technical problems is as follows:
a bismuth-containing burn dressing comprises a back adhesive layer, an antibacterial matrix layer and a release layer which are sequentially laminated; wherein, the liquid crystal display device comprises a liquid crystal display device,
the antibacterial matrix layer comprises a bismuth-containing polyurethane sponge layer;
the raw materials of the bismuth-containing polyurethane sponge layer comprise bismuth-containing compounds;
the bismuth-containing compound is introduced into the bismuth-containing polyurethane sponge layer by a first-in-last foaming mode.
Optionally, the raw materials of the bismuth-containing polyurethane sponge layer comprise the following components in parts by weight:
optionally, the bismuth-containing compound is selected from at least one of bismuth nitrate, bismuth citrate, bismuth tribromophenol, bismuth subsalicylate, bismuth-thiol composition.
Optionally, the antibacterial substrate layer further comprises a permeation layer coated on the bismuth-containing polyurethane sponge layer; the permeable layer is positioned on one side of the bismuth-containing polyurethane sponge layer, which is close to the release layer.
Optionally, the permeable layer is a honey layer.
Optionally, an absorbent layer is also included between the release layer and the antimicrobial matrix layer.
Optionally, the absorbing layer is a hydrocolloid layer.
Optionally, the hydrocolloid layer comprises the following raw materials in parts by weight:
optionally, the thickness of the antibacterial substrate layer is 0.1-5mm; the thickness of the absorption layer is 0.5-0.8mm.
Another object of the present invention is to provide a method for preparing the bismuth-containing burn dressing as described above, comprising the steps of:
s1: according to the formula amount, the raw materials of the bismuth-containing polyurethane sponge layer are mixed and then the bismuth-containing polyurethane sponge layer is prepared by a one-step foaming method;
s2: coating a permeable layer on the bismuth-containing polyurethane sponge layer to obtain an antibacterial matrix layer;
s3: weighing raw materials of the absorption layer according to the formula amount, and preparing the absorption layer by a kneader;
s4: and compounding the back adhesive layer, the antibacterial matrix layer, the absorption layer and the release layer in sequence to obtain the bismuth-containing burn dressing.
The beneficial effects of the invention are as follows:
the bismuth-containing burn dressing provided by the invention is introduced with the bismuth-containing polyurethane sponge layer prepared by the first adding-then foaming mode, so that the bismuth-containing compound is embedded into the sponge matrix, thereby avoiding a great amount of bismuth-containing compound from falling off and gathering at a wound surface in a short time while guaranteeing the antibacterial effect of the dressing, improving the safety, prolonging the release time of the bismuth-containing compound and being beneficial to realizing long-acting antibacterial effect.
Drawings
The invention will be further described with reference to the drawings and examples.
Fig. 1 is a schematic view of the construction of a bismuth-containing burn dressing of the present invention.
In the figure: 1-a back-attaching layer; 2-an antimicrobial matrix layer; 3-releasing layer; 4-an absorbent layer.
Detailed Description
The present invention will now be described in further detail. The embodiments described below are exemplary and intended to illustrate the invention and should not be construed as limiting the invention, as all other embodiments, based on which a person of ordinary skill in the art would obtain without inventive faculty, are within the scope of the invention.
In order to solve the problem that bismuth compounds of tribromophenol bismuth Vaseline dressing in the prior art are easy to burst, the invention provides a bismuth-containing burn dressing, which is shown in fig. 1, and comprises a back adhesive layer 1, an antibacterial substrate layer 2 and a release layer 3 which are sequentially laminated; wherein the back-attaching layer 1 can be made of common materials such as polyurethane film; the release layer 3 can be release paper, and the bismuth-containing burn dressing can be self-adhesive dressing or non-self-adhesive dressing; in the use process, after the release layer 3 is uncovered, the dressing is applied to the wound so that the antibacterial substrate layer 2 is contacted with the wound; to promote wound healing, the preferred antimicrobial matrix layer 2 of the present invention comprises a bismuth-containing polyurethane sponge layer; the bismuth-containing polyurethane sponge layer comprises bismuth-containing compounds as raw materials, so that the bismuth-containing compounds can be used for resisting bacteria at wound surfaces; in order to avoid that a large amount of bismuth-containing compound falls off and gathers at the wound surface and enters blood, the bismuth-containing compound is preferably introduced into the bismuth-containing polyurethane sponge layer in a first-in-later-foaming mode.
Specifically, the mode of firstly adding and then foaming refers to firstly adding the bismuth-containing compound into the raw material for preparing the polyurethane sponge, and then performing foaming reaction to prepare the polyurethane sponge, so that the bismuth-containing compound is embedded into a porous sponge matrix with a three-dimensional network structure in the preparation process, and further a slow release effect is achieved, on one hand, the bismuth-containing compound can be prevented from falling off and gathering at a wound surface in a large amount in a short time, the safety is improved, and on the other hand, the release time of the bismuth-containing compound can be prolonged, and the service life of the bismuth-containing burn dressing is prolonged.
The bismuth-containing burn dressing provided by the invention is introduced with the bismuth-containing polyurethane sponge layer prepared by the first adding-then foaming mode, so that the bismuth-containing compound is embedded into the sponge matrix, thereby avoiding a great amount of bismuth-containing compound from falling off and gathering at a wound surface in a short time while guaranteeing the antibacterial effect of the dressing, improving the safety, prolonging the release time of the bismuth-containing compound and being beneficial to realizing long-acting antibacterial effect.
In order to ensure the antibacterial effect, the raw materials of the bismuth-containing polyurethane sponge layer preferably comprise the following components:
the preparation process of the bismuth-containing polyurethane sponge layer comprises the following steps:
according to the formula amount, the raw materials are placed in a container, uniformly stirred at a high speed, rapidly extruded into a polytetrafluoroethylene flat groove die with the depth of 0.1-10 mm, dried, demoulded and wound to obtain a bismuth-containing polyurethane sponge layer; according to the invention, the bismuth-containing compound is added into the raw material of the polyurethane sponge, and is effectively and uniformly distributed in the whole polyurethane sponge matrix through a one-step foaming process, and is firmly embedded into the three-dimensional network structure of the matrix, so that the bismuth-containing compound is prevented from falling off and gathering at wound surfaces in a large amount in a short time, and long-acting antibacterial effect is realized.
The bismuth-containing compound of the present invention is preferably at least one selected from bismuth nitrate, bismuth citrate, bismuth tribromophenol, bismuth subsalicylate, and bismuth-thiol composition.
In order to ensure the release rate of the bismuth-containing compound, the antibacterial substrate layer 2 of the present invention preferably further comprises a permeation layer coated on the bismuth-containing polyurethane sponge layer; the permeable layer is positioned on one side of the bismuth-containing polyurethane sponge layer, which is close to the release layer 3, so that in the use process, the permeable layer absorbs the seepage at the wound surface through the high permeability of the permeable layer, and the seepage is conveyed to the bismuth-containing polyurethane sponge layer to play a role in debridement, prevent the impregnation of the wound, maintain the moist environment of the wound and promote the wound repair; meanwhile, the bismuth-containing compound slowly convects to the wound through the osmotic pressure effect, so that the slow release effect is further realized, the bismuth-containing compound is prevented from being gathered at the wound in a large amount in a short time, and meanwhile, the stable long-acting antibacterial effect of the dressing is realized.
Further, the preferred osmotic layer of the present invention is a honey layer, and further preferred the honey layer is a manuka honey layer; the invention preferably coats the honey on the bismuth-containing polyurethane sponge layer in a spraying or dipping mode, wherein in the coating process, a part of honey enters pores of the bismuth-containing polyurethane sponge layer through extrusion and capillary action, and a part of honey is coated on the surface of the bismuth-containing polyurethane sponge layer; through the honey layer, on one hand, the high permeability of honey is utilized to absorb the penetrating fluid at the wound surface and transfer the penetrating fluid into the polyurethane sponge layer matrix, so that a debridement effect is achieved, the impregnation of the wound is prevented, and the moist environment of the wound is maintained; meanwhile, the strong-acid Manuka honey can effectively neutralize weak-alkaline wound exudate, prevent the continuous stimulation of the exudate to the wound and effectively weaken bacterial growth (the general growth environment of bacteria is neutral or weak-alkaline); moreover, the bismuth-containing compound can be slowly and convectively migrated to the wound surface under the action of the penetrating fluid; on the other hand, the honey has the characteristic of acidity, so that the honey entering the bismuth-containing polyurethane sponge layer can promote the indissolvable bismuth-containing compound to release bismuth ions into a matrix, and then slowly and convectively migrate to a wound through the osmotic pressure effect, thereby realizing long-acting stable antibacterial effect, reducing the replacement frequency, being easy to remove during replacement and having good comfort and fit in high-low temperature environments.
In order to achieve both the release rate of bismuth ions and the antibacterial effect, the preferred honey of the invention has the coating weight of 250-300g/m 2 。
In order to further optimize the release rate of bismuth ions, the bismuth-containing burn dressing provided by the invention further comprises an absorption layer 4 positioned between the release layer 3 and the antibacterial substrate layer 2, wherein in the use process, the absorption layer 4 is in contact with a wound surface, the seepage at the wound surface is conveyed to a permeable layer through the absorption layer 4, the seepage is conveyed to a bismuth-containing polyurethane sponge layer through the permeable layer, and meanwhile, the bismuth ions released in the bismuth-containing polyurethane sponge layer are conveyed to the wound surface after passing through the permeable layer and the absorption layer 4 in sequence through convection under the action of osmotic pressure.
It is further preferred according to the invention that the absorption layer 4 is a hydrocolloid layer in order to facilitate absorption of the liquid by the absorption layer 4.
Further, the invention preferably comprises the following raw materials in parts by weight:
the hydrocolloid layer prepared from the raw materials can absorb seepage on one hand, and the release speed of bismuth ions is controlled by combining the seepage layer and the bismuth-containing polyurethane sponge layer on the other hand, so that the bismuth ions are prevented from gathering at wound surfaces in a large amount in a short time, and meanwhile, the long-acting antibacterial effect of the dressing is realized; meanwhile, the hydrocolloid layer is directly contacted with the wound surface, and secondary damage caused by easy embedding of fabric dressing fibers into wound granula can be avoided.
Further, the thickness of the antibacterial base layer 2 is preferably 0.1 to 5mm; the thickness of the absorption layer 4 is 0.5-0.8mm so as to give consideration to the durability and safety of the antibacterial property of the dressing.
The bismuth-containing burn dressing provided by the invention has the advantages that the bismuth ions are mediated to accumulate in microbial organelles and destroy the microbial organelles, so that microorganisms are killed, and the bismuth-containing compound is introduced into the bismuth-containing polyurethane sponge layer, so that the antibacterial effect is realized by releasing the bismuth ions. Meanwhile, the preparation method inhibits the formation of bacterial biofilm, prevents bacteria or microorganism proliferation, maintains the wound in a sterile or low-bacteria state, and reduces the infection risk of epithelial tissues, thereby providing good healing and growing environment for burn wounds or skin tissues. The slightly acidic honey may cause the water-insoluble bismuth-containing compound powder to release bismuth ions into the matrix, which may effect bismuth ion release into the wound area in one or a combination of the following ways: i) Slow convective migration to the wound site by osmotic pressure; ii) migration to the wound site by gravity from top to bottom; and the absorption layer 4 is combined again, so that bismuth ions can be released to the wound surface at a proper speed, and long-acting stable antibacterial effect is realized.
Another object of the present invention is to provide a method for preparing the bismuth-containing burn dressing as described above, comprising the steps of:
s1: according to the formula amount, the raw materials of the bismuth-containing polyurethane sponge layer are mixed and then the bismuth-containing polyurethane sponge layer is prepared by a one-step foaming method;
specifically, the preparation method comprises the following steps of weighing raw materials of the bismuth-containing polyurethane sponge layer according to the formula, placing the weighed raw materials into a container, stirring uniformly at a high speed, rapidly extruding the raw materials into a polytetrafluoroethylene flat groove die with the depth of 0.1-10 mm, drying, demolding and rolling to obtain the bismuth-containing polyurethane sponge layer;
s2: coating a permeable layer on the bismuth-containing polyurethane sponge layer to obtain an antibacterial substrate layer 2;
transferring the bismuth-containing polyurethane sponge layer to a coating machine, quantitatively spraying Manuka honey at a constant speed (double-sided twice), and extruding by a pair of rollers (double-sided twice), so as to prepare an antibacterial substrate layer 2;
s3: weighing raw materials of the absorption layer according to the formula amount, and preparing an absorption layer 4 through a kneader;
the preparation method specifically comprises the steps of weighing raw materials of an absorption layer according to the formula amount, adding SIS thermoplastic elastomer, liquid paraffin, vegetable oil, petroleum resin, rosin glyceride, 2, 6-di-tert-butyl cresol and dibutyl phthalate into a kneader, mixing and stirring uniformly at the temperature of 130 ℃ at the rotating speed of 45r/min, adding gelatin, pectin, sodium carboxymethyl cellulose and crosslinked carboxymethyl cellulose grafted acrylamide, mixing and stirring, and coating the uniformly mixed materials on release paper to obtain an absorption layer 4; the preferable water absorption rate of the crosslinked carboxymethyl cellulose grafted acrylamide is 350-450g/g;
s4: and compounding the back adhesive layer 1, the antibacterial matrix layer 2, the absorption layer 4 and the release layer 3 in sequence to obtain the bismuth-containing burn dressing.
The preparation method of the bismuth-containing burn dressing provided by the invention has the advantages that the preparation process is simple, the bismuth-containing polyurethane sponge layer prepared by the first adding-then foaming mode is introduced, so that the bismuth-containing compound is embedded into the sponge matrix, the antibacterial effect of the dressing is ensured, the bismuth-containing compound is prevented from falling off and gathering at a wound surface in a large amount in a short time, the safety is improved, the release time of the bismuth-containing compound is prolonged, and the long-acting antibacterial effect is realized; meanwhile, the absorption effect of the absorption layer 4, the permeation layer and the bismuth-containing polyurethane sponge layer are utilized to control the release speed of bismuth ions by combining the absorption layer 4, the permeation layer and the bismuth ion content in the bismuth-containing polyurethane sponge layer, so that the long-acting antibacterial effect of the dressing is realized while the bismuth ions are prevented from gathering at wound surfaces in a large amount in a short time.
In order that the above objects, features and advantages of the invention will be readily understood, a more particular description of the invention will be rendered by reference to specific embodiments thereof which are illustrated in the appended drawings.
Example 1
The embodiment provides a bismuth-containing burn dressing, which comprises a back adhesive layer 1, an antibacterial matrix layer 2, an absorption layer 4 and a release layer 3 which are sequentially laminated; wherein, the liquid crystal display device comprises a liquid crystal display device,
the back adhesive layer 1 is a polyurethane film;
the antibacterial matrix layer 2 comprises a bismuth-containing polyurethane sponge layer and a Manuka honey layer coated on the bismuth-containing polyurethane sponge layer;
the bismuth-containing polyurethane sponge layer comprises the following raw materials in parts by weight:
the coating weight of the Manuka honey layer is 280g/m 2 。
The thickness of the antibacterial base layer 2 was 3mm.
The absorption layer 4 comprises the following components in parts by weight:
the thickness of the absorbent layer 4 was 0.6mm.
The release layer 3 is release paper.
Example 2
The difference between this example and example 1 is that the bismuth compound is added in an amount of 1.5 parts in the raw material of the bismuth-containing polyurethane sponge layer.
Example 3
The difference between this example and example 1 is that the bismuth compound is added in an amount of 1.7 parts in the raw material of the bismuth-containing polyurethane sponge layer.
Example 4
The difference between this example and example 1 is that the coating weight of the Manuka honey layer is 250g/m 2 。
Example 5
The difference between this example and example 1 is that the coating weight of the Manuka honey layer is 300g/m 2 。
Comparative example 1
The difference between this comparative example and example 1 is that the bismuth compound is added in an amount of 0.5 parts to the raw material of the bismuth-containing polyurethane sponge layer.
Comparative example 2
The difference between this comparative example and example 1 is that the bismuth compound is added in an amount of 2.5 parts to the raw material of the bismuth-containing polyurethane sponge layer.
Comparative example 3
This comparative example differs from example 1 in that no permeation layer was included.
Comparative example 4
The present comparative example differs from example 1 in that the absorbent layer 4 is not included.
Comparative example 5
The difference between this comparative example and example 1 is that the thickness of the absorbent layer 4 is 1mm.
Comparative example 6
The difference between this comparative example and example 1 is that the raw material of the absorbent layer 4 was not added with crosslinked carboxymethyl cellulose grafted acrylamide.
Comparative example 7
The present comparative example differs from example 1 in that 5 parts by weight of isopropyl alcohol and 10 parts by weight of crosslinked carboxymethyl cellulose grafted acrylamide were used instead of crosslinked carboxymethyl cellulose grafted acrylamide in the absorbent layer 4.
Bismuth-containing burn dressings prepared in the above examples and comparative examples were tested as follows:
1. liquid absorbency test
Liquid absorption test is carried out by preparing the liquid A according to the step A in the liquid absorption of the 1 st part of the method for testing the YY/T0471.1-2004 contact wound dressing, and the test sample is 5cm multiplied by 5cm;
2. bismuth ion Release test
The solution A was prepared as dissolution medium for this test according to the procedure in part 1 of the procedure for liquid absorbency of YY/T0471.1-2004 contact wound dressing test method. A beaker was filled with 500ml of solution A, the sample was cut into 50cm by 50cm dressing, the release layer was removed and the absorbent layer was placed up to the bottom of the beaker for dissolution testing. Since the dressing is generally used for a single piece of time of not more than 7 days, the sampling points are set to 1 day, 3 days, 5 days and 7 days. Bismuth ion elution amount was measured by ICP-MS method.
The test results are shown in Table 1:
TABLE 1
From the data, the bismuth-containing burn dressing provided by each embodiment has excellent liquid absorption capacity through the synergistic effect of the absorption layer 4, the permeation layer and the bismuth-containing polyurethane sponge layer, and meanwhile bismuth ions can be slowly released to the wound surface.
Comparative example 1 has reduced the amount of bismuth-containing compound added as compared with example 1, and the bismuth-containing compound content is smaller, so that the total bismuth ion elution amount of the dressing is low, and the release rate is low, resulting in poor antibacterial effect;
comparative example 2 compared with example 1, the addition amount of the bismuth-containing compound was increased, and the bismuth ion release rate and the total release amount were both remarkably increased, so that a large amount of bismuth ions accumulated at the wound surface in a short time;
compared with the example 1, the comparative example 3 is not provided with a permeable layer, the initial leaching amount of bismuth ions (1 day) is obviously reduced, the leaching total amount and the release rate are slightly reduced, and the liquid absorption amount is slightly increased because the polyurethane sponge pores do not absorb honey;
comparative example 4 compared with example 1, no absorbent layer was provided, the liquid absorption was significantly reduced, and at the same time, the bismuth ion release rate was accelerated, so that bismuth ions were accumulated at the wound surface in a short period of time;
comparative example 5, compared to example 1, increased the thickness of the absorbent layer, increased the liquid absorption capacity of the absorbent layer 4, resulting in a significant increase in the liquid absorption capacity of the dressing, but it impeded the transfer of bismuth ions, resulting in a small decrease in the bismuth ion release rate;
comparative example 6 compared with example 1, the raw material of the absorbent layer 4 was not added with the crosslinked carboxymethyl cellulose grafted acrylamide, the liquid absorbing capacity of the absorbent layer 4 was decreased, resulting in a decrease in the liquid absorbing capacity of the bismuth-containing burn dressing, and at the same time, an increase in the bismuth ion release rate;
comparative example 7 the liquid absorption capacity of the absorbent layer 4 was significantly increased compared to example 1, resulting in significantly increased liquid absorption capacity of the bismuth-containing burn dressing, so that the bismuth ion release rate was too low, the total amount of free bismuth ions delivered to the wound surface within 7 days was reduced, and the antibacterial effect was deteriorated.
With the above-described preferred embodiments according to the present invention as an illustration, the above-described descriptions can be used by persons skilled in the relevant art to make various changes and modifications without departing from the scope of the technical idea of the present invention. The technical scope of the present invention is not limited to the description, but must be determined according to the scope of claims.
Claims (10)
1. The bismuth-containing burn dressing is characterized by comprising a back adhesive layer (1), an antibacterial matrix layer (2) and a release layer (3) which are sequentially laminated; wherein, the liquid crystal display device comprises a liquid crystal display device,
the antibacterial matrix layer (2) comprises a bismuth-containing polyurethane sponge layer;
the raw materials of the bismuth-containing polyurethane sponge layer comprise bismuth-containing compounds;
the bismuth-containing compound is introduced into the bismuth-containing polyurethane sponge layer by a first-in-last foaming mode.
2. The bismuth-containing burn dressing according to claim 1, wherein the raw materials of the bismuth-containing polyurethane sponge layer comprise the following components in parts by weight:
3. the bismuth-containing burn dressing of claim 2, wherein the bismuth-containing compound is selected from at least one of bismuth nitrate, bismuth citrate, bismuth tribromophenol, bismuth subsalicylate, bismuth-thiol compositions.
4. A bismuth-containing burn dressing according to any one of claims 1-3, wherein the antimicrobial base layer (2) further comprises a permeation layer coated on the bismuth-containing polyurethane sponge layer; the permeable layer is positioned on one side of the bismuth-containing polyurethane sponge layer, which is close to the release layer (3).
5. The bismuth-containing burn dressing of claim 4, wherein the permeable layer is a honey layer.
6. Bismuth-containing burn dressing according to claim 4, further comprising an absorbent layer (4) between the release layer (3) and the antimicrobial matrix layer (2).
7. Bismuth-containing burn dressing according to claim 6, characterized in that the absorbent layer (4) is a hydrocolloid layer.
8. The bismuth-containing burn dressing of claim 7, wherein the hydrocolloid layer comprises the following components in parts by weight:
9. bismuth-containing burn dressing according to claim 6, characterized in that the thickness of the antibacterial matrix layer (2) is 0.1-5mm; the thickness of the absorption layer (4) is 0.5-0.8mm.
10. A method of preparing a bismuth-containing burn dressing according to any one of claims 1 to 9, comprising the steps of:
s1: according to the formula amount, the raw materials of the bismuth-containing polyurethane sponge layer are mixed and then the bismuth-containing polyurethane sponge layer is prepared by a one-step foaming method;
s2: coating a permeable layer on the bismuth-containing polyurethane sponge layer to obtain an antibacterial substrate layer (2);
s3: weighing raw materials of the absorption layer according to the formula amount, and preparing the absorption layer (4) through a kneader;
s4: and compounding the back adhesive layer (1), the antibacterial matrix layer (2), the absorption layer (4) and the release layer (3) in sequence to obtain the bismuth-containing burn dressing.
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| CN202310878367.2A CN116672488A (en) | 2023-07-17 | 2023-07-17 | Bismuth-containing burn dressing and preparation method thereof |
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| CN202310878367.2A CN116672488A (en) | 2023-07-17 | 2023-07-17 | Bismuth-containing burn dressing and preparation method thereof |
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