CN116661172A - Wireless electronic cornea contact lens capable of regulating and controlling drug release - Google Patents
Wireless electronic cornea contact lens capable of regulating and controlling drug release Download PDFInfo
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- CN116661172A CN116661172A CN202310470128.3A CN202310470128A CN116661172A CN 116661172 A CN116661172 A CN 116661172A CN 202310470128 A CN202310470128 A CN 202310470128A CN 116661172 A CN116661172 A CN 116661172A
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- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 2
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- DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 description 1
- YVIGPQSYEAOLAD-UHFFFAOYSA-L disodium;dodecyl phosphate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOP([O-])([O-])=O YVIGPQSYEAOLAD-UHFFFAOYSA-L 0.000 description 1
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Classifications
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/046—Contact lenses having an iris pattern
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/047—Contact lens fitting; Contact lenses for orthokeratology; Contact lenses for specially shaped corneae
-
- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
- Y02E60/14—Thermal energy storage
Landscapes
- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
Abstract
The invention discloses a wireless electronic cornea contact lens capable of regulating and controlling drug release, which comprises a cornea contact lens and an external energy transmission module in wireless connection with the cornea contact lens, wherein the cornea contact lens comprises: a corneal contact lens anterior base; the medicine storage medium is overlapped with the rear surface of the front base of the cornea contact lens, can generate phase change under the action of electric energy-induced physical change, chemical change or physiological change, and releases medicine in the conversion process; the energy receiving module is overlapped with the rear surface of the medicine storage medium, generates controllable electric energy according to the acquired wireless signals, and realizes controllable electric energy-induced physical, chemical or physiological change by utilizing the electric energy; the cornea contact lens back base is overlapped with the back surface of the energy receiving module. The obtained electric energy generates electro-physical, electro-chemical and electro-physiological changes in a local range, and the physical, chemical and physiological changes induced by the electric energy can control the phase change of the medicine storage medium and regulate the speed and dosage of the medicine released from the medicine storage medium to the ocular surface.
Description
Technical Field
The invention relates to the field of contact lens technology and ocular drug delivery, in particular to a wireless electronic cornea contact lens capable of regulating and controlling drug release.
Background
Ocular surface drug release is the first choice, and even the primary treatment, for many ophthalmic diseases and ocular disorders. At present, release of ocular surface drugs is mainly realized by eye drops and ointments commercially, but the methods can lead to rapid increase of the drug concentration of ocular surface microenvironment in a short time, and excessive drug concentration can cause irritation and even drug toxic damage to ocular surface biological tissues (cornea epithelium, conjunctival goblet cells and lacrimal glands). In order to avoid the side effects caused by the release of traditional ophthalmic drugs, some researches and published patents relate to micro-channels and drug storage layers on a corneal contact lens to delay the release of drugs on the ocular surface. As in chinese patent CN217409130U, a drug delivery contact lens and an ophthalmic drug delivery device are disclosed, which use the pressure on the lens at blinking time to achieve drug release, and although it can achieve drug release control, these drug delivery contact lens devices are designed and manufactured, and their own physical structure and chemical characteristics determine that the release rate of the drug is difficult to allow flexible control, so it is difficult to meet the individual drug treatment requirements of different disease types, different disease degrees, and different physiological conditions of patients.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a wireless electronic cornea contact lens capable of regulating and controlling drug release.
In order to achieve the above purpose, the present invention provides the following technical solutions:
the utility model provides a but wireless electron contact lens of regulation and control medicine release, its includes the contact lens and with its wireless connection's external energy delivery module, the contact lens obtains controllable electric energy through receiving the energy of outside wireless transmission to utilize the electric energy control contact lens inside to take place physical change, chemical change or physiological change, control medicine storage medium and take place the phase transition, change medicine storage medium to the constraint ability of medicine, and then the controllable regulation contact lens's of release speed or dose, contact lens includes:
a corneal contact lens anterior base;
the energy receiving module is overlapped with the rear surface of the front base of the cornea contact lens, generates controllable electric energy according to the acquired wireless signals, and realizes controllable electric energy to cause physical change, chemical change or physiological change by utilizing the electric energy and a circuit hardware unit;
the medicine storage medium is overlapped with the rear surface of the energy receiving module, can generate phase change under the action of electric energy-induced physical change, chemical change or physiological change, realizes the conversion between solid state and liquid state, and releases medicine due to the reduction of the binding capacity of medicine storage medium molecules to medicine molecules in the process of converting the medicine storage medium from the solid state to the liquid state and the conversion process;
the cornea contact lens back base is overlapped with the back surface of the energy receiving module.
The external energy transmission module is a wireless transmitting device with controllable power or energy transmission efficiency.
The wireless signal is electromagnetic wave, light or magnetic field.
The medicine storage medium is made of ion-responsive phase change material or temperature-sensitive responsive phase change material.
The front base of the cornea contact lens and the rear base of the cornea contact lens are made of cornea contact lens materials with hydrophilic and oxygen permeable properties.
The medicine storage medium is a phase change material film mixed or doped with medicine molecules.
The medicine storage medium can realize solid-liquid phase change in the electro-physical, chemical or physiological change of the energy receiving module, and the medicine release rate is regulated by controlling the speed of the solid-liquid phase change.
The invention has the beneficial effects that: according to the needs of the wearer, the flexible wireless energy receiving module can acquire electric energy through external electromagnetic waves, laser or other wireless energy transmission modes. The obtained electric energy generates electro-physical, electro-chemical and electro-physiological changes in a local range, and the physical, chemical and physiological changes induced by the electric energy can control the phase change of the medicine storage medium and regulate the speed and dosage of the medicine released from the medicine storage medium to the ocular surface.
Drawings
Fig. 1 is a schematic structural view of the present invention.
Fig. 2 is a schematic diagram of the present invention.
Fig. 3 is a schematic diagram of embodiment 1 of the present invention.
Fig. 4 is a schematic diagram of embodiment 2 of the present invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that all directional indicators (such as up, down, left, right, front, and rear … …) in the embodiments of the present invention are merely used to explain the relative positional relationship, movement, etc. between the components in a particular posture (as shown in the drawings), and if the particular posture is changed, the directional indicator is changed accordingly.
In the present invention, unless specifically stated and limited otherwise, the terms "connected," "affixed," and the like are to be construed broadly, and for example, "affixed" may be a fixed connection, a removable connection, or an integral body; the connection can be mechanical connection or connection; either directly or indirectly, through intermediaries, or both, may be in communication with each other or in interaction with each other, unless expressly defined otherwise. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art according to the specific circumstances.
As shown in the figure, the wireless electronic cornea contact lens capable of regulating and controlling the drug release comprises a cornea contact lens and an external energy delivery module which is in wireless connection with the cornea contact lens, wherein the external energy delivery module and the cornea contact lens are in wireless connection, the energy delivery is realized, and the output power or the energy delivery efficiency of the external energy delivery module is controllable, namely, a user can manually regulate the output power or the energy delivery efficiency of the energy delivery module.
The cornea contact lens utilizes wireless signals transmitted by an external energy transmission module to acquire controllable electric energy, and utilizes the acquired electric energy to cause physical change, chemical change or physiological change, so as to controllably adjust the drug release rate or dosage of the cornea contact lens, and the cornea contact lens comprises:
the front base of the cornea contact lens is made of transparent materials so as to further reduce the influence on visual perception, and is formed into a curved disc, wherein one side of the curved disc, which is provided with a concave surface for storing a medicine medium and an energy receiving module, is distributed around the pupil area of the front base of the cornea contact lens, and is sequentially attached to one side of the concave surface of the front base of the cornea contact lens, and the pupil area is a circular area with the diameter of 0.5-8 mm;
the energy receiving module is overlapped with the rear surface of the front base of the cornea contact lens, generates controllable electric energy according to the acquired wireless signals, and utilizes the electric energy to realize controllable electric energy to cause physical change, chemical change or physiological change;
the medicine storage medium is overlapped with the rear surface of the energy receiving module, can generate phase change under the action of electric energy-induced physical change, chemical change or physiological change, realizes solid, liquid or gaseous conversion, and releases medicine in the conversion process;
electro-physical changes such as electro-temperature transformation, electro-optical transformation, electro-mechanical transformation, electro-temperature transformation: through setting up the resistance, act on the heat production through electric current and realize the heat to the temperature-sensitive phase change material carries out the phase transition, the heat that the electric energy that obtains through the energy receiving module produced.
Electrochemical reaction and electrophoresis attraction ion aggregation, wherein the electrophoresis attraction ion aggregation leads to the increase of ion concentration in a local range by respectively attracting anions and cations near an anode and a cathode, and causes the ion-responsive phase-change material to generate phase change, namely, causes the ion concentration change in a corresponding range by positive and negative electrodes of an energy receiving module.
The electrophysiological changes attract or convert the generated charged biochemical molecules (e.g., polypeptides, proteins, ascorbic acid, gluconic acid) near the electrodes by electrophoresis, resulting in an increase in the concentration of the biochemical molecules in a local area, which initiates the phase change of the phase change material array.
The energy receiving module is a wireless electric energy receiving circuit arranged on a polyimide film, a polyethylene terephthalate film, a polyurethane film or a polyethylene naphthalate film, wherein the conductive material is a metal material, a conductive alloy material or a conductive nanowire, a nanofiber or a two-dimensional conductive nanomaterial.
The flexible energy receiving module is prepared by adopting micro-nano processing (including photoetching film deposition, screen printing and ink-jet printing) technology to deposit circuits (one surface is a wireless electric energy receiving circuit and the other surface is a phase-change polymer array-based variable circuit) on the front and back sides of a polyimide film, a polyethylene terephthalate film, a polyurethane film or a polyethylene naphthalate film, punching through holes through machinery or laser, and connecting the circuits on the front and back sides to form conductive circuits through the through holes by using conductive materials.
The back base of the cornea contact lens is made of transparent materials, is overlapped with the back surface of the energy receiving module to form a curved disc, the curved disc is provided with one side with a concave surface suitable for being matched with the cornea surface of the eye, the concave surface of the curved disc does not interfere eyelid movement when being installed on the eye, the circumference of the convex surface of the curved disc is matched with the circumference of the concave surface of the front base of the cornea contact lens, and the medicine storage medium and the energy receiving module are covered in a sealing space formed by the concave surface and the convex surface.
The front base and the rear base of the cornea contact lens are made of hydrogel, the thickness of the front base and the rear base is less than 100 microns, (the three-dimensional network structure on the microscopic level has no blocking effect on the diffusion of the ophthalmic micromolecular medicaments, and the cornea contact lens is similar to a sponge after water absorption), the medicaments released from the medicament storage medium can permeate out of the rear base to separate from the cornea contact lens, and the rear base of the cornea contact lens is contacted with the cornea surface, so that the medicaments are directly released to the cornea surface.
The thickness of the flexible wireless energy receiving module and the thickness of the stored medicine medium are very light and thin and are integrated in the cornea contact lens, and the base arc, thickness, diameter, oxygen permeation effect, surface hydrophilicity and flexibility of the cornea contact lens are not influenced, so that wearing comfort and biosafety of the cornea contact lens released by the medicine can be ensured to the greatest extent.
The wireless signal is electromagnetic wave, light or magnetic field or other wireless energy transmission modes, and the power or energy transmission efficiency is directly regulated through the wireless transmitting device to change the current or voltage value acquired by the energy receiving module, so that the controllable regulation of the drug release speed or dosage of the cornea contact lens is realized.
I.e. the phase change of the drug storage medium, enhances the diffusion rate of drug molecules from the medium layer to the ocular surface. When the high-speed release of the medicine is not needed, the wireless energy transmission efficiency or the power of energy emission is reduced, and then the electric energy in the wireless energy receiving module is weakened, so that the medicine storage medium is recovered to be solid from liquid (or gel state), and the diffusion speed of medicine molecules from the medium layer to the ocular surface is reduced.
The medicine storage medium is made of ion-responsive phase change material or temperature-sensitive responsive phase change material.
The drug storage medium is a ring-shaped phase change film coated on the surface of the wireless energy receiving module, and drug molecules are mixed or doped in the medium.
Wherein the temperature sensitive material adopts poly N-isopropyl acrylamide and a composite material mixed with the doping agent, agar and a composite material mixed with the doping agent, disodium dodecyl phosphate and a composite material mixed with the doping agent.
The ionic material adopts PH responsive gel, calcium ion responsive gel, sodium ion responsive gel, potassium ion responsive gel and other materials capable of causing swelling or shrinkage deformation by ions.
As an illustration of one way, the phase change material may undergo a liquid-solid transition due to a change in microenvironment such as temperature, ion concentration, etc. When the wireless power supply is executed, the microenvironment of the medicine storage medium is changed through the actions of electric heating, electrochemistry and the like, so that the medicine storage medium is changed from a solid state to a liquid state or a gel state, the binding strength of medicine storage medium molecules to the medicine molecules is low, and the diffusion coefficient of the medicine molecules in the medicine storage medium is high, so that the medicine molecules are easy to exude from the medicine storage medium, and finally pass through the cornea contact lens and then are released on the ocular surface. When the wireless power supply is stopped, the medicine storage medium is recovered from a liquid state to a solid state because the temperature and the ion concentration in the microenvironment are recovered to the original levels. At this time, the binding capacity of the solid drug storage medium molecules to the drug molecules becomes strong, and the diffusion coefficient of the drug molecules in the inside thereof is low, so that the drug molecules are difficult to exude from the drug storage medium, which can continuously encapsulate the remaining drug in the corneal contact lens without being released to the ocular surface.
Example 1
A method for wireless electronic temperature control and regulation of drug release of a contact lens of a cornea, which comprises the following steps:
the flexible wireless energy receiving module acquires electric energy through an external light source, a changed electromagnetic field and a magnetic field, the acquired electric energy regulates and controls temperature change, so that the temperature-sensitive phase-change material is subjected to phase change conversion (shown in figure 3), wherein the temperature-sensitive phase-change material is poly-N-isopropyl acrylamide and a composite material mixed with a doping agent, agar and a composite material mixed with a doping agent, disodium dodecahydrate phosphate and a composite material mixed with a doping agent, and the wireless energy receiving module changes the phase of the temperature-sensitive material through controlling the change of the environmental temperature, so that the binding capacity of the temperature-sensitive material to drug molecules is regulated, and the release rate and the dosage of the drug molecules to an ocular surface are controlled.
Example 2
A method of wireless electrophoretic recruitment of ions to modulate release of drug from a contact lens:
the flexible wireless energy receiving module is enabled to acquire electric energy through an external light source, a changed electromagnetic field and a magnetic field, the acquired electric energy is respectively used for attracting anions and cations near an anode and a cathode in an electrophoresis mode, so that the ion concentration in a local range is increased (shown in figure 4), the ion-responsive medicine storage layer is triggered to generate phase change, the ion-responsive medicine storage medium is a pH-responsive gel, a calcium ion-responsive gel, a sodium ion-responsive gel, a potassium ion-responsive gel and other materials with ions capable of causing swelling or shrinkage deformation, the change of the ion concentration in the local range is achieved through the wireless energy receiving module, the ion-sensitive material is enabled to generate phase change, and therefore the binding capacity of the ion-sensitive material to medicine molecules is controlled, and the rate and the dosage of the medicine molecules released to an eye surface are controlled.
The examples should not be construed as limiting the invention, but any modifications based on the spirit of the invention should be within the scope of the invention.
Claims (7)
1. A wireless electronic contact lens capable of regulating and controlling drug release, which is characterized in that: the cornea contact lens comprises a cornea contact lens and an external energy transmission module which is in wireless connection with the cornea contact lens, wherein the cornea contact lens acquires controllable electric energy by receiving energy transmitted by external wireless, and utilizes the acquired electric energy to control the inside of the cornea contact lens to generate physical change, chemical change or physiological change, control a medicine storage medium to generate phase change and change the binding capacity of the medicine storage medium to medicine, so as to controllably adjust the medicine release rate or dosage of the cornea contact lens, and the cornea contact lens comprises:
a corneal contact lens anterior base;
the energy receiving module is overlapped with the rear surface of the front base of the cornea contact lens, generates controllable electric energy according to the acquired wireless signals, and realizes controllable electric energy to cause physical change, chemical change or physiological change by utilizing the electric energy and a circuit hardware unit;
the medicine storage medium is overlapped with the rear surface of the energy receiving module, can generate phase change under the action of electric energy-induced physical change, chemical change or physiological change, realizes the conversion between solid state and liquid state, and releases medicine due to the reduction of the binding capacity of medicine storage medium molecules to medicine molecules in the process of converting the medicine storage medium from the solid state to the liquid state and the conversion process;
the cornea contact lens back base is overlapped with the back surface of the energy receiving module.
2. A wireless electronic contact lens with controlled drug release according to claim 1, wherein: the external energy transmission module is a wireless transmitting device with controllable power or energy transmission efficiency.
3. A wireless electronic contact lens with controlled drug release according to claim 1 or 2, characterized in that: the wireless signal is electromagnetic wave, light or magnetic field.
4. A wireless electronic contact lens with controlled drug release according to claim 1, wherein: the medicine storage medium is made of ion-responsive phase change material or temperature-sensitive responsive phase change material.
5. A wireless electronic contact lens with controlled drug release according to claim 1, wherein: the front base of the cornea contact lens and the rear base of the cornea contact lens are made of cornea contact lens materials with hydrophilic and oxygen permeable properties.
6. A wireless electronic contact lens with controlled drug release according to claim 1, wherein: the medicine storage medium is a phase change material film mixed or doped with medicine molecules.
7. A wireless electronic contact lens for controlled drug release according to claim 6, wherein: the medicine storage medium can realize solid-liquid phase change in the electro-physical, chemical or physiological change of the energy receiving module, and the medicine release rate is regulated by controlling the speed of the solid-liquid phase change.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310470128.3A CN116661172A (en) | 2023-04-27 | 2023-04-27 | Wireless electronic cornea contact lens capable of regulating and controlling drug release |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310470128.3A CN116661172A (en) | 2023-04-27 | 2023-04-27 | Wireless electronic cornea contact lens capable of regulating and controlling drug release |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116661172A true CN116661172A (en) | 2023-08-29 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310470128.3A Pending CN116661172A (en) | 2023-04-27 | 2023-04-27 | Wireless electronic cornea contact lens capable of regulating and controlling drug release |
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| Country | Link |
|---|---|
| CN (1) | CN116661172A (en) |
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2023
- 2023-04-27 CN CN202310470128.3A patent/CN116661172A/en active Pending
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